NTR-pro-opiomelanocortin-neuron (#2649)

* exact synonym

exact synonym

* Fix Conflict

src/ontology/cl-edit.owl

@@ -3080,6 +3080,7 @@ Declaration(Class(obo:CL_4042030))
 Declaration(Class(obo:CL_4042031))
 Declaration(Class(obo:CL_4042032))
 Declaration(Class(obo:CL_4042033))
+Declaration(Class(obo:CL_4042034))
 Declaration(Class(obo:CL_4047006))
 Declaration(Class(obo:CL_4047007))
 Declaration(Class(obo:CL_4047011))
@@ -3179,6 +3180,7 @@ Declaration(Class(obo:PR_000007785))
 Declaration(Class(obo:PR_000009981))
 Declaration(Class(obo:PR_000010529))
 Declaration(Class(obo:PR_000012318))
+Declaration(Class(obo:PR_000013015))
 Declaration(Class(obo:PR_000013047))
 Declaration(Class(obo:PR_000013433))
 Declaration(Class(obo:PR_000013502))
@@ -32641,17 +32643,29 @@ SubClassOf(obo:CL_4042032 ObjectSomeValuesFrom(obo:RO_0002202 obo:UBERON_0004026
 SubClassOf(obo:CL_4042032 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534))
 SubClassOf(obo:CL_4042032 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000012318))
 
-# Class: obo:CL_4042033 (CGRP-expressing neuron)
+# Class: obo:CL_4042033 (pro-opiomelanocortin neuron)
 
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") obo:IAO_0000115 obo:CL_4042033 "An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25870542") Annotation(oboInOwl:hasDbXref "PMID:28192062") obo:IAO_0000115 obo:CL_4042033 "A neuron of the central nervous system that expresses POMC and synthesizes the POMC precursor polypeptide. This neuron type is located in the arcuate nucleus of the hypothalamus and in the nucleus tractus solitarius of the brainstem. The pro-opiomelanocortin neuron is part of the central melanocortin system and it is involved in regulating energy homeostasis, metabolism, and appetite. This neuronal type responds to hormonal signals such as levels of leptin and insulin, and its activation results in the release of α-melanocyte-stimulating hormone (α-MSH), which acts on melanocortin receptors to suppress food intake and increase energy expenditure.")
 AnnotationAssertion(terms:contributor obo:CL_4042033 <https://orcid.org/0000-0002-0098-8958>)
-AnnotationAssertion(terms:date obo:CL_4042033 "2024-10-30T15:35:08Z"^^xsd:dateTime)
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasExactSynonym obo:CL_4042033 "Calcitonin gene-related peptide neuron")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasRelatedSynonym obo:CL_4042033 "CGRP-expressing interneuron")
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasRelatedSynonym obo:CL_4042033 "CGRP-positive neuron")
-AnnotationAssertion(rdfs:label obo:CL_4042033 "CGRP-expressing neuron"@en)
-SubClassOf(obo:CL_4042033 obo:CL_0000526)
-SubClassOf(obo:CL_4042033 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001017))
+AnnotationAssertion(terms:date obo:CL_4042033 "2024-10-15T10:17:41Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34002087") oboInOwl:hasRelatedSynonym obo:CL_4042033 "POMC neuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34002087") oboInOwl:hasRelatedSynonym obo:CL_4042033 "POMC-expressing neuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28192062") Annotation(oboInOwl:hasDbXref "PMID:33633406") rdfs:comment obo:CL_4042033 "Pro-opiomelanocortin neurons have a diverse projection pattern. The neurons in the rostral arcuate nucleus project to autonomic areas, caudal arcuate POMC neurons project mainly to hypothalamic areas (Toda et al., 2017). Dysregulation of pro-opiomelanocortin neurons is associated with obesity and metabolic disorders (Quarta et al., 2020).")
+AnnotationAssertion(rdfs:label obo:CL_4042033 "pro-opiomelanocortin neuron"@en)
+SubClassOf(obo:CL_4042033 obo:CL_0000165)
+SubClassOf(obo:CL_4042033 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000013015))
+
+# Class: obo:CL_4042034 (CGRP-expressing neuron)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") obo:IAO_0000115 obo:CL_4042034 "An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn.")
+AnnotationAssertion(terms:contributor obo:CL_4042034 <https://orcid.org/0000-0002-0098-8958>)
+AnnotationAssertion(terms:date obo:CL_4042034 "2024-10-30T15:35:08Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasExactSynonym obo:CL_4042034 "Calcitonin gene-related peptide neuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasRelatedSynonym obo:CL_4042034 "CGRP-expressing interneuron")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34061020") oboInOwl:hasRelatedSynonym obo:CL_4042034 "CGRP-positive neuron")
+AnnotationAssertion(rdfs:label obo:CL_4042034 "CGRP-expressing neuron"@en)
+SubClassOf(obo:CL_4042034 obo:CL_0000526)
+SubClassOf(obo:CL_4042034 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0001017))
 
 # Class: obo:CL_4047006 (fetal artery endothelial cell)