import cobra
#!wget http://www.ebi.ac.uk/biomodels-main/download?mid=MODEL1603150001 -O recon2.2.xml
Recon2 = cobra.io.read_sbml_model("Models/recon2.2.xml")cobra/io/sbml.py:235 �[1;31mUserWarning�[0m: M_h_x appears as a reactant and product FAOXC220200x
hela_model=cobra.io.read_sbml_model(filename='Full_HeLa_model_1218_DEMEM6429_n5_pf2500.sbml')
kerat_model=cobra.io.read_sbml_model(filename='Full_Kerat_model_1218_DEMEM6429_n5_pf2500.sbml')hela_model=cobra.io.read_sbml_model(filename='Full_HeLa_model_1218_DEMEM6429_n5_pf2500.sbml')
kerat_model=cobra.io.read_sbml_model(filename='Full_Kerat_model_1218_DEMEM6429_n5_pf2500.sbml')
scc_model=cobra.io.read_sbml_model(filename='Full_SCC_model_0119_western_diet_n5_pf2500.sbml')
nor_model=cobra.io.read_sbml_model(filename='Full_Normal_model_0119_western_diet_n5_pf2500.sbml')for rx in scc_model.reactions:
print(rx.id, "\t", rx.name)13DAMPPOX 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
2HBO 2-Hydroxybutyrate:NAD+ oxidoreductase
34DHOXPEGOX 3,4-Dihydroxyphenylethyleneglycol:NAD+ oxidoreductase
3HAO 3-hydroxyanthranilate 3,4-dioxygenase
3SALACBOXL 3-Sulfino-L-alanine carboxy-lyase
3SALAOX cysteinesulfinic acid oxidase
3SALATAim 3-sulfino-alanine transaminase (irreversible), mitochondrial
3SPYRSPm 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
A_MANASEly alpha-mannosidase, lysosomal
AACOAT Acetoacetyl-CoA:acetate CoA-transferase
ABTD L-arabinitol 4-dehydrogenase
ABUTD Aminobutyraldehyde dehydrogenase
ACACT10m acetyl-CoA C-acetyltransferase, mitochondrial
ACACT1x acetyl-CoA C-acetyltransferase, mitochondrial
ACACT5p acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
ACACT6p acetyl-CoA C-acetyltransferase (dodecanoyl), peroxisomal
ACACT7p acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
ACCOAC acetyl-CoA carboxylase
ACGAM6PSi N-acetylglucosamine-6-phosphate synthase
ACGAMK N-acetylglucosamine kinase
ACGAMPM phosphoacetylglucosamine mutase
ACITL ATP-Citrate lyase
ACNAM9PL N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
ACNAMPH N-Acetylneuraminate 9-phosphate phosphohydrolase
ACNMLr N-Acetylneuraminate lyase (reversible)
ACOAD10m acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
ACONT aconitase
ACONTm Aconitate hydratase
ACP1_FMN_ acid phosphatase (FMN)
ADA Adenosine deaminase
ADAe Adenosine deaminase, extracellular
ADCim Acetoacetate decarboxylation (irreversible), mitochondrial
ADK3m adentylate kinase (GTP)
ADNK1m adenosine kinase, mitochondrial
ADPRDP ADPribose diphosphatase
ADSK adenylyl-sulfate kinase
ADSL1 adenylosuccinate lyase
ADSS adenylosuccinate synthase
AG13T10g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T11g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T12g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T13g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T14g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T15g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T16g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T17g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T18g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T1g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T2g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T3g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T4g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T5g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T6g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T7g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T8g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AG13T9g N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
AGDC N-acetylglucosamine-6-phosphate deacetylase
AGTim alanine-glyoxylate transaminase (irreversible), mitochondrial
AGTix alanine-glyoxylate transaminase (irreversible), (peroxisomal)
AHC adenosylhomocysteinase
AHEXASE2ly beta-N-acetylhexosaminidase, lysosomal
AHEXASEly beta-N-acetylhexosaminidase, lysosomal
AKR1C42 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
AKR1D2 aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
ALASm 5-aminolevulinate synthase
ALCD1 alcohol dehydrogenase (methanol)
ALCD21_L alcohol dehydrogenase (L-1,2-propanediol)
ALCD22_L alcohol dehydrogenase (L-lactaldehyde)
ALCD2if alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
ALCD2yf alcohol dehydrogenase (ethanol, NADP), forward reaction
ALDD21 aldehyde dehydrogenase (pristanal, NAD)
ALDD2x aldehyde dehydrogenase (acetaldehyde, NAD)
ALDD2xm aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
ALDD2y aldehyde dehydrogenase (acetaldehyde, NADP)
ALR2 aldose reductase (methylglyoxal)
ALR3 aldose reductase (acetol)
AMACR2p alpha-methylacyl-CoA racemase (reductase)
AMANK N-acetyl-D-mannosamine kinase
AMPDA Adenosine monophosphate deaminase
AMY1e alpha-amylase, extracellular (strch1 -> strch2)
AMY2e alpha-amylase, extracellular (glygn2 -> glygn4)
APAT2rm 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
ARABR arabinose reductase
ARACHCPT1 carnitine acyltransferase I
ARACHCPT2 carnitine acyltransferase II
ARGSL argininosuccinate lyase
ARGSS argininosuccinate synthase
R_group_phosphotase_3 R group phosphotase 3
ARTPLM3 R group to palmitate conversion
ASAH1 N-acylsphingosine amidohydrolase
ASCBOX ascorbic acid oxidase
ASP1DC aspartate 1-decarboxylase
ASPTAm aspartate transaminase
B_MANNASEly beta-mannosidase, lysosomal
B3GALTg Beta galactosyltransferase
B3GNT51g UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BAMPPALDOX beta-Aminopropion aldehyde:NAD+ oxidoreductase
BDMT_U GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
BETALDHxm betaine-aldehyde dehydrogenase, mitochondrial
BILIRED Nad(p)h biliverdin reductase
BPNT 3,5-bisphosphate nucleotidase
BPNT2 3,5-bisphosphate nucleotidase (paps)
C14STRr C-14 sterol reductase
C161CPT1 production of palmitoleoylcarnitine
C204CPT1 carnitine C20:4 transferase
C226CPT1 carnitine C22:6 transferase
C226CPT2 C226 transport into the mitochondria
C3STDH1Pr C-3 sterol dehydrogenase (4-methylzymosterol)
C3STKR2r C-3 sterol keto reductase (zymosterol)
C4STMO1r C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
C4STMO2r C-4 methyl sterol oxidase
CAT2p catalase A, peroxisomal (ethanol)
CATm catalase
CATp catalase A, peroxisomal
CDIPTr phosphatidylinositol synthase (Homo sapiens)
CDS phosphatidate cytidylyltransferase
CDSm phosphatidate cytidylyltransferase
CHOLD2m choline dehydrogenase (FAD acceptor), mitochondrial
CK ATP Creatine kinase
CLS_hs cardiolipin synthase (homo sapiens)
CMPSAS CMP sialic acid synthase
CMPSASn CMP sialic acid synthase, nuclear
CORE2GTg Core 2 acetylglucosaminyltransferase, Golgi apparatus
CORE3GTg Core 3 beta-GlcNAc-transferase, Golgi apparatus
CORE4GTg Core 4 beta6-GalNAc-transferase, Golgi apparatus
CORE5GTg Core 5 alpha-GalNAc-transferase, Golgi apparatus
CORE6GTg Core 6 beta-GlcNAc-transferase A, Golgi apparatus
CORE7GTg Core 7 alpha-GalNAc-transferase, Golgi apparatus
CPPPGO coproporphyrinogen oxidase (O2 required)
CRTNsyn Creatinine synthase
CSm citrate synthase
CYSGLTH Glutathione:cystine oxidoreductase
CYSO cysteine oxidase
CYSTA cysteine transaminase
CYSTAm cysteine transaminase (mitochondrial)
CYTDK1 ATPcytidine 5-phosphotransferase
CYTDK2m cytidine kinase (ATP), mitochondrial
CYTK1 cytidylate kinase (CMP)
CYTK10 cytidylate kinase (CMP,dGTP)
CYTK10n cytidylate kinase (CMP,dGTP),nuclear
CYTK11 cytidylate kinase (dCMP,dGTP)
CYTK11n cytidylate kinase (dCMP,dGTP),nuclear
CYTK12 cytidylate kinase (dCMP,dCTP)
CYTK12n cytidylate kinase (dCMP,dCTP),nuclear
CYTK13 cytidylate kinase (dCMP,dATP)
CYTK13n cytidylate kinase (dCMP,dATP),nuclear
CYTK14 cytidylate kinase (dCMP,UTP)
CYTK14n cytidylate kinase (dCMP,CTP),nuclear
CYTK1m cytidylate kinase (CMP),mitochondrial
CYTK1n cytidylate kinase (CMP),nuclear
CYTK2 cytidylate kinase (dCMP)
CYTK2n cytidylate kinase (dCMP),nuclear
CYTK3 cytidylate kinase (CMP)(GTP)
CYTK3n cytidylate kinase (dCMP,CTP),nuclear
CYTK4 cytidylate kinase (dCMP)(GTP)
CYTK4n cytidylate kinase (dCMP,GTP),nuclear
CYTK5 cytidylate kinase (dCMP)
CYTK5n cytidylate kinase (CMP),nuclear
CYTK6 cytidylate kinase (CMP,CTP)
CYTK6n cytidylate kinase (CMP,CTP),nuclear
CYTK7 cytidylate kinase (CMP,UTP)
CYTK7n cytidylate kinase (CMP,UTP),nuclear
CYTK8 cytidylate kinase (CMP,dATP)
CYTK8n cytidylate kinase (CMP,dATP),nuclear
CYTK9 cytidylate kinase (CMP,dCTP)
CYTK9n cytidylate kinase (CMP,dCTP),nuclear
DADA Deoxyadenosine deaminase
DADNK deoxyadenosine kinase
DAGK_hs Diacylglycerol phosphate kinase (homo sapiens)
DASCBR dehydroascorbate reductase
DCSPTN1CPT1 carnitine O-palmitoyltransferase
DCSPTN1CPT2 carnitine transferase
DDPGAm 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
DESAT16_2 palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
DESAT18_3 stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
DESAT18_4 stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
DESAT18_5 stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
DESAT18_9 fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
DESAT20_1 fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
DESAT20_2 fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
DGAT diacylglycerol acyltransferase
DGK1 deoxyguanylate kinase (dGMP:ATP)
DGK2m deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
DGULND dehydro-L-gulonate decarboxylase
DHCR241r 24-dehydrocholesterol reductase [Precursor]
DHCR242r 24-dehydrocholesterol reductase [Precursor]
DHCR243r 24-dehydrocholesterol reductase [Precursor]
DHCR71r 7-dehydrocholesterol reductase
DHCR72r 7-dehydrocholesterol reductase
DLNLCGCPT1 carnitine O-palmitoyltransferase
DLNLCGCPT2 carnitine transferase
DM_atp_c_ DM atp(c)
DMATTx dimethylallyltranstransferase
DOLASNT_Uer Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
DOLDPP_Uer Dolichyl-diphosphate phosphohydrolase, human (uterus)
DOLGPP_Uer Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase (uterus)
DOLPGT1_Uer dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
DOLPGT2_Uer dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
DOLPGT3_Uer dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
DOLPMT_U Dolichyl-phosphate D-mannosyltransferase (uterus)
DOLPMT1_Uer dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
DOLPMT2_Uer dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
DOLPMT3_Uer dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
DOLPMT4_Uer dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
DPGase Diphosphoglycerate phosphatase
DPGM Diphosphoglyceromutase
DPMVDx diphosphomevalonate decarboxylase
DRPA deoxyribose-phosphate aldolase
DSAT dihydrosphingosine N-acyltransferase
DURIK1 deoxyuridine kinase (ATP:Deoxyuridine)
DURIPP deoxyuridine phosphorylase
DUTPDPm dUTP diphosphatase
DUTPDPn dUTP diphosphatase, nuclear
EBP1r 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
EBP2r 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
ECOAH12m 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
ECOAH1m 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
ECOAH9m 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
EHGLAT2m L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
EHGLATm L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
ENGASE2ly endo-beta-N-acetylglucosaminidase, lysosomal
ENGASE3ly endo-beta-N-acetylglucosaminidase, lysosomal
ENGASEly endo-beta-N-acetylglucosaminidase, lysosomal
ENO enolase
F1PGT fucose-1-phosphate guanylyltransferase
F6Tg glycoprotein 6-alpha-L-fucosyltransferase
FACOAL160i fatty-acid--CoA ligase (palmitate, n-C16:0)
FACOAL161 fatty-acid--CoA ligase (hexadecenoate)
FACOAL180i fatty-acid--CoA ligase (stearate, n-C18:0)
FACOAL1812 fatty-acid--CoA ligase
FACOAL184 fatty-acid--CoA ligase
FACOAL2042 fatty-acid--CoA ligase
FACOAL205 fatty-acid--CoA ligase
FACOAL224 fatty-acid--CoA ligase
FACOAL2251 fatty-acid--CoA ligase
FACOAL2252 fatty-acid--CoA ligase
FACOAL226 fatty-acid--CoA ligase
FACOAL80i fatty-acid--CoA ligase (octanoate, n-C8:0)
FADDP FAD diphosphatase
FAEL183 fatty-acyl-CoA elongation (n-C18:3CoA)
FAEL184 fatty-acyl-CoA elongation (n-C20:4CoA)
FAEL204 fatty-acyl-CoA elongation (n-C20:4CoA)
FAEL205 fatty-acyl-CoA elongation (n-C20:5CoA)
FALDH formaldehyde dehydrogenase
FAOXC200180m fatty acid beta oxidation(C20-->C18)m
FAOXC2031836m Beta oxidation of fatty acid
FAOXC2051843m Beta oxidation of fatty acid
FAOXC2251836m Beta oxidation of fatty acid
FAOXC226205m Beta oxidation of long chain fatty acid
FBA fructose-bisphosphate aldolase
FBA2 D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
FBA4 D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
FBP26 Fructose-2,6-bisphosphate 2-phosphatase
FCLTm Ferrochelatase, mitochondrial
FE3R2e Fe(III) reduction (ascorbate)
FK Fucokinase
FKYNH N-Formyl-L-kynurenine amidohydrolase
FPGS folylpolyglutamate synthetase
FPGS2 folylpolyglutamate synthetase
FPGS3 folylpolyglutamate synthetase
FPGS4 folylpolyglutamate synthetase (DHF)
FPGS5 folylpolyglutamate synthetase (DHF)
FPGS6 folylpolyglutamate synthetase (DHF)
FPGS7 folylpolyglutamate synthetase (10fthf)
FPGS8 folylpolyglutamate synthetase (10fthf)
FPGS9 folylpolyglutamate synthetase (10fthf)
FTHFL Formate-tetrahydrofolate ligase
FUCASE2ly alpha-fucosidase, lysosomal
FUCASEe alpha-fucosidase, extracellular
FUCASEly alpha-fucosidase, lysosomal
FUM fumarase
FUMm fumarase, mitochondrial
FUT31g fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) 1
G12MT1_U Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
G12MT2_U Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
G13MT_U Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
G14T10g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T11g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T12g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T13g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T14g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T15g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T16g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T17g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T18g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T19g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T20g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T21g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T2g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T3g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T4g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T5g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T6g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T7g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T8g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14T9g beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
G14Tg beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
G16MT_U Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
G6PDA glucosamine-6-phosphate deaminase
G6PDH2r glucose 6-phosphate dehydrogenase
GALASE10ly beta-galactosidase, lysosomal
GALASE11ly beta-galactosidase, lysosomal
GALASE12ly beta-galactosidase, lysosomal
GALASE13ly beta-galactosidase, lysosomal
GALASE14ly beta-galactosidase, lysosomal
GALASE15ly beta-galactosidase, lysosomal
GALASE16ly beta-galactosidase, lysosomal
GALASE17ly beta-galactosidase, lysosomal
GALASE18ly beta-galactosidase, lysosomal
GALASE19ly beta-galactosidase, lysosomal
GALASE1ly beta-galactosidase, lysosomal
GALASE20ly beta-galactosidase, lysosomal
GALASE3ly beta-galactosidase, lysosomal
GALASE4ly beta-galactosidase, lysosomal
GALASE5ly beta-galactosidase, lysosomal
GALASE6ly beta-galactosidase, lysosomal
GALASE7ly beta-galactosidase, lysosomal
GALASE8ly beta-galactosidase, lysosomal
GALASE9ly beta-galactosidase, lysosomal
GALC Galactocerebrosidase
GALNTg GalNAc transferase, Golgi apparatus
GALOR D-Galactose:NADP+ 1-oxidoreductase
GALU UTP-glucose-1-phosphate uridylyltransferase
GAPD glyceraldehyde-3-phosphate dehydrogenase
GASNASE2ly glycosylasparaginase, lysosomal
GASNASE3ly glycosylasparaginase, lysosomal
GASNASEly glycosylasparaginase, lysosomal
GBA Glucosylceramidase
GCALDD Glycolaldehyde dehydrogenase
GCC2cm glycine-cleavage complex (lipoamide), mitochondrial
GFUCS GDP-L-fucose synthase
GGH_10FTHF5GLUl Gamma-glutamyl hydrolase (10FTHF5GLU), lysosomal
GGH_10FTHF6GLUl Gamma-glutamyl hydrolase (10FTHF6GLU), lysosomal
GGH_10FTHF7GLUl Gamma-glutamyl hydrolase (10FTHF7GLU), lysosomal
GGH_5DHFl Gamma-glutamyl hydrolase (5DHF), lysosomal
GGH_5THFl Gamma-glutamyl hydrolase (5THF), lysosomal
GGH_6DHFl Gamma-glutamyl hydrolase (6DHF), lysosomal
GGH_6THFl Gamma-glutamyl hydrolase (6THF), lysosomal
GGH_7DHFl Gamma-glutamyl hydrolase (7DHF), lysosomal
GGH_7THFl Gamma-glutamyl hydrolase (7THF), lysosomal
GGT5r Gamma-glutamyltransferase 5
GHMT2rm glycine hydroxymethyltransferase, reversible, mitochondrial
GLCAASE8ly beta-glucuronidase, lysosomal
GLCAASE9ly beta-glucuronidase, lysosomal
GLCNACPT_U UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
GLCNACT_U UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
GLNS glutamine synthetase
GLUCYS Gamma-glutamylcysteine synthetase
GLUDC Glutamate Decarboxylase
GLUDxm glutamate dehydrogenase (NAD) (mitochondrial)
GLUDym glutamate dehydrogenase (NADP), mitochondrial
GLUNm glutaminase (mitochondrial)
GLXO1 glyoxylate oxidase
GLYCTO1p Glycolate oxidase, peroxisome
GLYOp glycine oxidase, perixosomal
GMAND GDP-D-mannose dehydratase
GMPS2 GMP synthase
GPDDA1 Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
GRTTx geranyltranstransferase
GTHO glutathione oxidoreductase
GTHOm glutathione oxidoreductase
GTHP glutathione peroxidase
GTHPe glutathione peroxidase (e)
GTHPm glutathione peroxidase, mitochondria
GTHS glutathione synthetase
GTPCI GTP cyclohydrolase I
GTPCIn GTP cyclohydrolase I, nuclear
GUAD guanine deaminase
GUAPRT guanine phosphoribosyltransferase
GULN3D L-gulonate 3-dehydrogenase
GULNDer gulonate dehydrogenase, endoplasmic reticulum
H2CO3D carboxylic acid dissociation
HACD1m 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
HACD1x 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (peroxisome)
HACD9m 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
HEX1 hexokinase (D-glucose:ATP)
HEX10 hexokinase (D-glucosamine:ATP)
HEX4 hexokinase (D-mannose:ATP)
HEX7 hexokinase (D-fructose:ATP)
HIBDm 3-hydroxyisobutyrate dehydrogenase, mitochondrial
HKYNH 3-Hydroxy-L-kynurenine hydrolase
HMBS hydroxymethylbilane synthase
HMGCOASi Hydroxymethylglutaryl CoA synthase (ir)
HMGLm hydroxymethylglutaryl-CoA lyase
HOXG Heme oxygenase 1
HPYRDC hydroxypyruvate decarboxylase
HPYRR2x hydroxypyruvate reductase (NADH)
HSD17B42x hydroxysteroid (17-beta) dehydrogenase 4
HSD17B4x hydroxysteroid (17-beta) dehydrogenase 4
HXPRT hypoxanthine phosphoribosyltransferase (Hypoxanthine)
HYPOE hypothetical enyme
HYPTROX Hypotaurine oxidase
ICDHxm Isocitrate dehydrogenase (NAD+)
ICDHy isocitrate dehydrogenase (NADP)
ICDHyp Isocitrate dehydrogenase (NADP+)
ICDHyrm Isocitrate dehydrogenase (NADP+)
ILETA isoleucine transaminase
IMPD IMP dehydrogenase
IPDDIx isopentenyl-diphosphate D-isomerase
KHK2 ketohexokinase (D-xylulose)
KYN kynureninase
LALDO D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
LCADi lactaldehyde dehydrogenase
LCADi_D lactaldehyde dehydrogenase
LCYSTATm L-Cysteate:2-oxoglutarate aminotransferase, mitochondrial
LCYSTCBOXL 3-Sulfoalanine carboxy-lyase
LDH_L L-lactate dehydrogenase
LDH_Lm L-lactate dehydrogenase
LEUTA leucine transaminase
LFORKYNHYD L-Formylkynurenine hydrolase
LGTHL lactoylglutathione lyase
LNLCCPT1 carnitine O-palmitoyltransferase
LNLCCPT2 carnitine transferase
LNLNCGCPT1 carnitine O-palmitoyltransferase
LNLNCGCPT2 carnitine transferase
LNSTLSr lanosterol synthase
LPASE lysophospholipase
LSTO1r Lathosterol oxidase
LSTO2r Lathosterol oxidase
LTA4H Leukotriene A-4 hydrolase
LTC4Sr Leukotriene C4 synthase
LTD4DP Leukotriene D4 dipeptidase
M1316Mg mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
M13N2Tg alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
M14NTg beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
M16NTg alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
MAN1PT2 mannose-1-phosphate guanylyltransferase (GDP)
MCCCrm methylcrotonoyl-CoA carboxylase, mitochondrial
MCLOR 3-Mercaptolactate:NAD+ oxidoreductase
MDH malate dehydrogenase
MDHm malate dehydrogenase, mitochondrial
MECOALm mesaconate--CoA ligase (ADP-forming), mitochondrial
MECOAS1m mesaconate--CoA ligase (GDP-forming)
METAT methionine adenosyltransferase
MEVK1x mevalonate kinase (atp)
MG1er mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
MG2er mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
MG3er mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
MGCHrm methylglutaconyl-CoA hydratase (reversible), mitochondrial
MGSA methylglyoxal synthase
MGSA2 methyglyoxylate synthase 2 (from g3p)
MI1345PP inositol-1,3,4,5-trisphosphate 5-phosphatase
MI134PP inositol-1,3,4-trisphosphate 1-phosphatase
MI145PK inositol-1,4,5-trisphosphate 3-kinase
MI14PP inositol-1,4-bisphosphate 1-phosphatase
MI1PP myo-inositol 1-phosphatase
MI34PP inositol-3,4-bisphosphate 4-phosphatase
MI3PP myo-inositol 3-phosphatase
MI4PP myo-inositol 4-phosphatase
MM5ag mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MM6bg mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MM7Cag mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MM7Cbg mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MM8Ag mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MM8Cg mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
MMSAD3m methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
MTHFC methenyltetrahydrofolate cyclohydrolase
MTHFCm methenyltetrahydrifikate cyclohydrolase, mitochondrial
MTHFD2 methylenetetrahydrofolate dehydrogenase (NAD)
MTHFD2m methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
MTHFDm methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
N4Tg N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
NACHEX10ly beta-N-acetylhexosaminidase, lysosomal
NACHEX11ly beta-N-acetylhexosaminidase, lysosomal
NACHEX12ly beta-N-acetylhexosaminidase, lysosomal
NACHEX13ly beta-N-acetylhexosaminidase, lysosomal
NACHEX14ly beta-N-acetylhexosaminidase, lysosomal
NACHEX15ly beta-N-acetylhexosaminidase, lysosomal
NACHEX16ly beta-N-acetylhexosaminidase, lysosomal
NACHEX17ly beta-N-acetylhexosaminidase, lysosomal
NACHEX18ly beta-N-acetylhexosaminidase, lysosomal
NACHEX19ly beta-N-acetylhexosaminidase, lysosomal
NACHEX20ly beta-N-acetylhexosaminidase, lysosomal
NACHEX21ly beta-N-acetylhexosaminidase, lysosomal
NACHEX22ly beta-N-acetylhexosaminidase, lysosomal
NACHEX23ly beta-N-acetylhexosaminidase, lysosomal
NACHEX24ly beta-N-acetylhexosaminidase, lysosomal
NACHEX25ly beta-N-acetylhexosaminidase, lysosomal
NACHEX26ly beta-N-acetylhexosaminidase, lysosomal
NACHEX27ly beta-N-acetylhexosaminidase, lysosomal
NADK NAD kinase
NADN NAD nucleosidase
NADS2 NAD synthase (glutamine-hydrolysing)
NAGA2ly N-acetylgalactosaminidase, alpha-
NAGLCAly N-acetylglucosaminidase, lysosomal
NBAHH_ir Nalpha-(beta-alanyl)-L-histidine hydrolase IR
NDP7er nucleoside-diphosphatase (UDP), endoplasmic reticulum
NDP7g nucleoside-diphosphatase (UDP), Golgi apparatus
NDPK3m nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
NDPK4 nucleoside-diphosphate kinase (ATP:dTDP)
NDPK6 Nucleoside-diphosphate kinase (ATP:dUDP)
NDPK6n nucleoside-diphosphate kinase (ATP:dUDP), nuclear
NDPK9 nucleoside-diphosphate kinase (ATP:IDP)
NICRNS NICRNS
NNMT Nicotinamide N-methyltransferase
NT5C Nicotinate D-ribonucleotide phosphohydrolase
NTD1 5-nucleotidase (dUMP)
NTD10 5-nucleotidase (XMP)
NTD11 5-nucleotidase (IMP)
NTD2 5-nucleotidase (UMP)
NTD3 5-nucleotidase (dCMP)
NTD4 5-nucleotidase (CMP)
NTD5 5-nucleotidase (dTMP)
NTD6 5-nucleotidase (dAMP)
NTD7 5-nucleotidase (AMP)
NTD8 5-nucleotidase (dGMP)
NTD9 5-nucleotidase (GMP)
OIVD1m 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
ORNTArm ornithine transaminase reversible (m)
P45027A13m 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
P45027A1m Cytochrome P450 27
P4508B11r sterol 12-alpha-hydroxylase
P4508B13r sterol 12-alpha-hydroxylase (nadh)
P450LTB4r cytochrome p450 leukotriene B4
P450SCC1m cholesterol monooxygenase
PCHOLP_hs choline phosphatase
PCHOLPm_hs choline phosphatase
PDXPP Pyridoxine 5-phosphate phosphatase
PETOHMm_hs phosphatidylethanolamine N-methyltransferase
PFK phosphofructokinase
PFK26 6-phosphofructo-2-kinase
PGI glucose-6-phosphate isomerase
PGK phosphoglycerate kinase
PGL 6-phosphogluconolactonase
PGM phosphoglycerate mutase
PGMT phosphoglucomutase
PGS Prostaglandin G/H synthase
PHCDm L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
PHETA1m phenylalanine transaminase (m)
PI345P5Pn phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase, nuclear
PI34P3Pn phosphatidylinositol-3,4-bisphosphate 3-phosphatase, nuclear
PI34P4Pn phosphatidylinositol-3,4-bisphosphate 4-phosphatase, nuclear
PI34P5Kn phosphatidylinositol 3,4-bisphosphate 5-kinase, nuclear
PI3P3Pn phosphatidylinositol-3-phosphate 3-phosphatase, nuclear
PI3P4Kn phosphatidylinositol 3-phosphate 4-kinase, nuclear
PI45P5P phosphatidylinositol-4,5-bisphosphate 5-phosphatase
PI45P5Pn phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
PI45PLC phosphatidylinositol 4,5-bisphosphate phospholipase C
PI4P3Kn phosphatidylinositol 4-phosphate 3-kinase, nuclear
PI4P5Kn phosphatidylinositol 4-phosphate 5-kinase, nuclear
PI4PLC phosphatidylinositol 4-phosphate phospholipase C
PI4PP phosphatidylinositol-4-phosphate 4-phosphatase
PI5P4Kn phosphatidylinositol-5-phosphate 4-kinase, nuclear
PIK3n phosphatidylinositol 3-kinase, nuclear
PIK4n phosphatidylinositol 4-kinase, nuclear
PIK5n phosphatidylinositol 5-kinase, nuclear
PIPLC phosphatidylinositol phospholipase C
PMANM phosphomannomutase
PMEVKx phosphomevalonate kinase
PNP purine-nucleoside phosphorylase
PNTEH Hydrolase Class ( RXN R02973)
PNTK pantothenate kinase
PPA inorganic diphosphatase
PPAn inorganic diphosphatase, nuclear
PPAP phosphatidic acid phosphatase
PPBNGS porphobilinogen synthase
PPM phosphopentomutase
PPPGOm protoporphyrinogen oxidase, mitochondrial
PRDX Peroxidase (multiple substrates)
PRPNCOAHYDm Propenoyl-CoA hydrolase (m)
PRPPS phosphoribosylpyrophosphate synthetase
PSSA1_hs Phosphatidylserine synthase homo sapiens
PTRCOX1 Putrescine:oxygen oxidoreductase (deaminating)
PUNP1 purine-nucleoside phosphorylase (Adenosine)
PUNP2 purine-nucleoside phosphorylase (Deoxyadenosine)
PUNP3 purine-nucleoside phosphorylase (Guanosine)
PUNP4 purine-nucleoside phosphorylase (Deoxyguanosine)
PUNP5 purine-nucleoside phosphorylase (Inosine)
PUNP6 purine-nucleoside phosphorylase (Deoxyinosine)
PYDAMK pyridoxamine kinase
PYDXK pyridoxal kinase
PYDXNK pyridoxine kinase
PYDXPP Pyridoxal 5-phosphate phosphatase
PYK pyruvate kinase
PYNP2r pyrimidine-nucleoside phosphorylase (uracil)
QUILSYN Quinolinate Synthase (Eukaryotic)
RADH2 retinal dehydrogenase (NADPH)
RAI3 13-cis-retinoic acid isomerase
RBFK riboflavin kinase
RDH1 retinol dehydrogenase (all-trans)
RDH1a retinol dehydrogenase (all-trans,NADPH)
RDH2 retinol dehydrogenase (9-cis,NADH)
RDH2a retinol dehydrogenase (9-cis,NADPH)
RDH3 retinol dehydrogenase (11-cis,NADH)
RDH3a retinol dehydrogenase (11-cis,NADPH)
RETFA retinol acyltransferase
RNDR1 ribonucleoside-diphosphate reductase (ADP)
RNDR2 ribonucleoside-diphosphate reductase (GDP)
RNDR3 ribonucleoside-diphosphate reductase (CDP)
RNDR4 ribonucleoside-diphosphate reductase (UDP)
RNMK ribosylnicotinamide kinase
RPE ribulose 5-phosphate 3-epimerase
RPI ribose-5-phosphate isomerase
S23T2g beta-galactoside alpha-2,3-sialyltransferase (core 2)
S23T3g beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
S23T4g beta-galactoside alpha-2,3-sialyltransferase
S26Tg beta-galactoside alpha-2,6-sialyltransferase
S6T10g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T11g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T12g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T13g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T14g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T15g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T16g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T17g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T18g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T1g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T2g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T3g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T4g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T5g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T6g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T7g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T8g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6T9g galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
S6TASE10ly galactose-6-sulfate sulfatase, lysosomal
S6TASE11ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE12ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE13ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE14ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE15ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE16ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE17ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE18ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE19ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE1ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE20ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE21ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE22ly galactose-6-sulfate sulfatase, lysosomal
S6TASE23ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE24ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE25ly galactose-6-sulfate sulfatase, lysosomal
S6TASE26ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE2ly N-acetylglucosamine-6-sulfatase, lysosomal
S6TASE3ly N-acetylglucosamine-6-sulfatase, lysosomal
SADT sulfate adenylyltransferase
SBTD_D2 sorbitol dehydrogenase
SBTR aldose reductase
SCP2x peroxisomal thiolase 2
SCPx peroxisomal thiolase 2
SFGTH S-Formylglutathione hydralase
SIAASE2ly sialidase, lysosomal
SIAASE3ly sialidase, lysosomal
SIAASE4ly sialidase, lysosomal
SIAASEly sialidase, lysosomal
SLCBK1 sphingolipid long chain base kinase (sphinganine)
SLDx L-sulfolactate dehydrogenase (NAD+)
SLDxm L-sulfolactate dehydrogenase (NAD+), mitochondrial
SMS Sphingomyelin synthase (homo sapiens)
SPHK21c sphingosine kinase 2
SPHMDAc sphingomyelin deacylase
SPMDOX Spermidine:(acceptor) oxidoreductase
SPODM superoxide dismutase
SPODMm superoxide dismutase
SPODMn superoxide dismutase, nuclear
SPODMx superoxide dismutase, peroxisome
SPTix serine-pyruvate aminotransferase (irreversible), peroxisomal
SQLEr Squalene epoxidase, endoplasmic reticular (NADP)
SQLSr Squalene synthase
SUCD1m succinate dehydrogenase
SUCOASm Succinate--CoA ligase (ADP-forming)
TALA transaldolase
TKT1 transketolase
TKT2 transketolase
TMDK1 thymidine kinase (ATP:thymidine)
TMDS thymidylate synthase
TPI triose-phosphate isomerase
TRIOK triokinase
TRPO2 L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
TYRCBOX L-Tyrosine carboxy-lyase
TYRTAm tyrosine transaminase, mitochondrial
UAG4E UDP-N-acetylglucosamine 4-epimerase
UAGDP UDP-N-acetylglucosamine diphosphorylase
UDPDOLPT_U UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
UDPG4E UDPglucose 4-epimerase
UDPGD UDPglucose 6-dehydrogenase
UGCG Ceramide glucosyltransferase
UGT1A10r UDP-glucuronosyltransferase 1-10 precursor, microsomal
UMPK UMP kinase
UMPK2 UMP kinase (CTP)
UMPK2n UMP kinase (CTP),nuclear
UMPK3 UMP kinase (UTP)
UMPK3n UMP kinase (UTP),nuclear
UMPK4 UMP kinase (GTP)
UMPK4n UMP kinase (GTP),nuclear
UMPK5 UMP kinase (dATP)
UMPK5n UMP kinase (dATP),nuclear
UMPK6 UMP kinase (dCTP)
UMPK6n UMP kinase (dCTP),nuclear
UMPK7 UMP kinase (dGTP)
UMPK7n UMP kinase (dGTP),nuclear
UMPKn UMP kinase, nuclear
UPP3S uroporphyrinogen-III synthase
UPPDC1 uroporphyrinogen decarboxylase (uroporphyrinogen III)
URIK1 uridine kinase (ATP:Uridine)
VALTA valine transaminase
VLCSp Very-long-chain-fatty-acid-CoA ligase
VLCSr Very-long-chain-fatty-acid-CoA ligase
XANDp xanthine dehydrogenase, peroxisomal
XAO2x xanthine oxidase
XAOx xanthine oxidase,peroxisomal
XYLTD_Dr xylitol dehydrogenase (D-xyulose-forming)
r0009 Pyrophosphate phosphohydrolase EC:3.6.1.1
r0010 hydrogen-peroxide:hydrogen-peroxide oxidoreductase EC:1.11.1.6
r0013 beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
r0016 Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
r0021 glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
r0022 glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
r0047 Adenosine 5-monophosphate phosphohydrolase Purine metabolism EC:3.1.3.5
r0055 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
r0082 Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
r0084 Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
r0086 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
r0120 GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
r0121 r0121
r0139 CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
r0149 CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
r0157 L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
r0160 L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
r0170 Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
r0173 (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
r0226 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
r0239 N-Formylanthranilate amidohydrolase Tryptophan metabolism EC:3.5.1.9
r0245 Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
r0246 Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
r0267 CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
r0268 cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
r0283 L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11
r0287 Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
r0301 Xanthosine-5-phosphate:ammonia ligase (AMP-forming) Purine metabolism EC:6.3.4.1
r0340 ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
r0345 ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
r0354 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0355 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0357 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0358 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0360 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0361 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0363 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0364 Glycolysis / Glyconeogenesis EC:2.7.1.1
r0365 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
r0377 ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
r0381 hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
r0383 pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1
r0386 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
r0391 Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
r0392 D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
r0393 D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
r0394 Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
r0395 Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
r0400 N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
r0407 Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
r0408 ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
r0422 Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
r0424 Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
r0426 isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
r0430 Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
r0431 Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
r0441 Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
r0444 Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
r0445 Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
r0456 ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
r0463 (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
r0464 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
r0470 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
r0472 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
r0474 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
r0475 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
r0494 dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
r0497 dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
r0502 xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
r0504 Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
r0510 steroyl-CoA,hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.1
r0511 steroyl-CoA,hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.1
r0527 Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
r0531 dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
r0539 Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
r0549 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
r0555 acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12
r0568 (5-L-Glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing) Glutathione metabolism EC:2.3.2.4
r0570 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
r0575 Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
r0578 ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
r0579 ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
r0580 N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
r0584 Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
r0595 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
r0596 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
r0604 (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
r0614 N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
r0618 trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
r0634 Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
r0639 Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
r0642 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
r0643 (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
r0656 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
r0660 (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0661 (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0668 CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
r0670 (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
r0671 (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
r0679 ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
r0680 ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
r0683 Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
r0686 L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
r0688 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
r0698 Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
r0706 acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
r0708 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
r0709 r0709
r0715 (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
r0717 (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0718 (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
r0719 (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
r0721 (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0722 (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
r0723 (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
r0726 (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
r0730 (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
r0731 (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0732 Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
r0733 (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
r0734 (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
r0739 alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1
r0741 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
r0743 hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
r0744 (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
r0750 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
r0758 5-Hydroxyindoleacetaldehyde:NAD+ oxidoreductase Tryptophan metabolism EC:1.2.1.3
r0774 Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
r0775 Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
r0776 r0776
r0777 GTP 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16
r0778 r0778
r0781 Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
r0782 GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
r0783 lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
r0784 xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
r0787 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
r0795 Spontaneous reaction
r1109 Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
r1135 hydroxysteroid (17-beta) dehydrogenase 7 Biosynthesis of steroids EC:1.1.1.270
r1146 Biosynthesis of steroids Enzyme catalyzed
r1167 EC:2.3.1.26
r1171 EC:2.3.1.26
r1177 EC:3.1.1.13
r1183 EC:3.1.1.13
r1378 S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
r1380 delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
r1382 folylpolyglutamyl synthetase EC:6.3.2.17
r1383 gamma-glutamyl hydrolase EC:3.4.19.9
r1384 Guanosine aminohydrolase EC:3.5.4.15
r1418 Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
r1443 EC:1.3.3.6
r1444 EC:1.3.3.6
r1448 EC:1.3.3.6
r1450 EC:1.3.3.6
r1466 EC:2.3.1.86
r1488 EC:6.2.1.3
RE0124C RE0124
RE0383C RE0383
RE0452M RE0452
RE0453C RE0453
RE0453N RE0453
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RE0512X RE0512
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RE0691C RE0691
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RE3626M RE3626
C10OHc production of 3-OHdecanoylcarnitinec
C120CPT1 production of dodecanoylcarnitine
C12OHc production of 3-OHdodecanoylcarnitinec
C142OHc production of 3-hydroxytetradeca dienoyl carnitine
C14OHc production of 3-hydroxytetradecanoylcarnitine
C18OHc production of 3-hydroxyoctadecanoylcarnitine
C50CPT1 production of isovalerylcarnitine
C51CPT1 production of tiglylcarnitine
C60CPT1 production of hexanoylcarnitine
C80CPT1 production of octanoylcarnitine
FAOXC101C8m fatty acid beta oxidation(C10:1-->C8)m
FAOXC101m isomerization(C10:1)m
FAOXC102C101m reduction(C10:2-->C10:1)m
FAOXC102C103m fatty acid beta oxidation(C10:2-->C10:3)m
FAOXC102C81m fatty acid beta oxidation(C10:2-->C8:1)m
FAOXC102m isomerization(C10:2)m
FAOXC103C102m fatty acid beta oxidation(C10:3-->C10:2)m
FAOXC10C10OHm fatty acid beta oxidation(C10-->OHC10)m
FAOXC10DCC8DCx fatty acid beta oxidation(C10DC-->C8DC)
FAOXC122C101m fatty acid beta oxidation(C12:2-->C10:1)m
FAOXC122m isomerization(C12:2)m
FAOXC123C102m fatty acid beta oxidation(C12:3-->C10:2)m
FAOXC123m isomerization(C12:3)m
FAOXC12C12OHm fatty acid beta oxidation(C12-->OHC12)m
FAOXC12DCC10DCx fatty acid beta oxidation(C12DC-->C10DC)x
FAOXC142C142OHm fatty acid beta oxidation(C14:2-->C14:2OH)m
FAOXC143C123m fatty acid beta oxidation(C14:3-->C12:3)m
FAOXC14C14OHm fatty acid beta oxidation(C14-->C14OH)m
FAOXC14DCC12DCx fatty acid beta oxidation(C14DC-->C12DC)x
FAOXC162C142m fatty acid beta oxidation(C16:2-->C14:2)m
FAOXC163C164Gm fatty acid beta oxidation(C16:3-->C16:4)gm
FAOXC163GC142m fatty acid beta oxidation(C16:3-->C14:2)gm
FAOXC163Gm isomerization(C16:3)gm
FAOXC164C143m fatty acid beta oxidation(C16:4-->C14:3)m
FAOXC164C165m fatty acid beta oxidation(C16:4-->C16:5)m
FAOXC164GC163m fatty acid beta oxidation(C16:4-->C16:3)gm
FAOXC164m isomerization(C16:4)m
FAOXC165C164m fatty acid beta oxidation (C16:5-->C16:4)m
FAOXC16DCC14DCx fatty acid beta oxidation(C16DC-->C14DC)x
FAOXC16DCr fatty acid activation(C16DC)er
FAOXC181C161m fatty acid beta oxidation(C18:1-->C16:1)m
FAOXC182C162m fatty acid beta oxidation(C18:2-->C16:2)m
FAOXC183C163Gm fatty acid beta oxidation(C18:3-->C16:3)gm
FAOXC184C163m fatty acid beta oxidation (C18:4-->C16:3)m
FAOXC184C164m fatty acid beta oxidation(C18:4-->C16:4)m
FAOXC184m isomerization of (C18:4)m
FAOXC18C18OHm fatty acid beta oxidation(C18-->C18OH)m
FAOXC204C184m fatty acid beta oxidation(C20:4-->C18:4)m
FAOXC225C204m fatty acid beta oxidation(C22:5-->C20:4)m
FAOXC225C226m fatty acid beta oxidation(C22:5-->C22:6)m
FAOXC225m isomerization(C22:5)m
FAOXC226C205m fatty acid beta oxidation(C22:6-->C20:5)m
FAOXC226C225m fatty acid beta oxidation(C22:6-->C22:5)m
FAOXC226C227m fatty acid beta oxidation(C22:6-->C22:7)m
FAOXC226m isomerization(C22:6)m
FAOXC227C226m fatty acid beta oxidation(C22:7-->C22:6)m
FAOXC5C5OHm fatty acid beta oxidation(C5-->C5OH)m
FAOXC5OHc (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
FAOXC61m isomerization(C6:1)m
FAOXC6DCC4DCx fatty acid beta oxidation(C6DC-->C4DC)x
FAOXC81C61m fatty acid beta oxidation(C8:1-->C6:1)m
FAOXC8DCC6DCx fatty acid beta oxidation(C8DC-->C6DC)x
FAOXOHC16C16DCc fatty acid omega oxidation(w-OHC16-->C16DC)c
FAOXTC101TC102m fatty acid beta oxidation trans(C10:1-->C10:2)m
FAOXTC102C101m fatty acid beta oxidation trans(C10:2-->C10:1)m
FAOXTC122TC101m fatty acid beta oxidation trans(C12:2-->C10:1)m
FAOXTC122m isomerization trans(C12:2)m
FAOXTC142TC122m fatty acid beta oxidation trans(C14:2-->C12:2)m
OCD11COACPT1 transport of 11-octadecenoyl carnitine into the mitochondrial matrix
OCD11CRNCPT2 transport of 11-octadecenoyl carnitine into the mitochondrial matrix
SUCCOAPET thioesterification of succinyl coa for release into cytosol
ALAALACNc ALAALACNc
GLYGLYCNc hydrolysis of glycylycine for uptake
GLYLEUHYDROc hydrolysis of Glycylleucine in the small intestine for cellular uptake
GLYSARCNc Hydrolysis of glycylsarcosine for uptake
OAADC oxaloacetate decarboxylase
ADNK3 adenosine kinase
ADNK4 adenosine kinase
DPMVDc diphosphomevalonate decarboxylase, cytosol
DSREDUCr Desmosterol reductase
DUTPDP dUTP diphosphatase
FERO ferroxidase
FMNALKPle FMNALKPle
GLYC3PFADm glycerophosphate shuttle for trasnfer of reducing equivalents
HMGCOARc Hydroxymethylglutaryl CoA reductase (ir) in cytosol
INSK insosine kinase
MEVK1c mevalonate kinase (atp) cytosol
PMEVKc phosphomevalonate kinase, cytosol
SFCYSc Formation of sulfocysteine
NNDPR NNDPR
NADKm NADKm
10FTHF5GLUtl 5-glutamyl-10FTHF transport, lysosomal
10FTHF6GLUtl 6-glutamyl-10FTHF transport, lysosomal
10FTHF7GLUtl 7-glutamyl-10FTHF transport, lysosomal
10FTHFtl 10-Formyltetrahydrofolate lysosomal transport via diffusion
1MNCAMti N1-Methylnicotinamide transport
3MOPt2im 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
3SALAASPm cysteinesulfinate-aspartate mitochondrial shuttle
4MOPt2im 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
5AOPtm 5-Aminolevulinate mitochondrial transport
5DHFtl 5-glutamyl-DHF transport, lysosomal
5THFtl 5-glutamyl-THF transport, lysosomal
6DHFtl 6-glutamyl-DHF transport, lysosomal
6THFtl 6-glutamyl-THF transport, lysosomal
7DHFtl 7-glutamyl-DHF transport, lysosomal
7THFtl 7-glutamyl-THF transport, lysosomal
ABTti L-arabinitol transport via passive diffusion
ACACt2m Acetoacetate mitochondrial transport via H+ symport
ACALDt acetaldehyde reversible transport
ACALDtm acetaldehyde mitochondrial diffusion
ACALDtx acetaldehyde peroxisomal diffusion
ACCOAgt acetyl-coa transport
ACCOAtr acetyl-coa transport
ACGAMtly N-acetyl-glucosamine lysosomal efflux
ACNAMlt N-acetylneuraminate transport into lysososme
ACNAMtn N-acetylneuraminate nuclear import
ACt2m acetate mitochondrial transport via proton symport
ACt2r acetate reversible transport via proton symport
ADNtm adenosine facilated transport in mitochondria
ADRNt fatty acid transport via diffusion
AHCYStr S-Adenosyl-L-homocysteine intracellular diffusion
ALAt2r L-alanine reversible transport via proton symport
ALAt4 Alanine-Sodium symporter
AMETr S-Adenosyl-L-methionine intracellular diffusion
ARAB_Lt L-arabinoase extracellular transport
ARACHCRNt carnitine/acylcarnitine translocase
ARACHDCOAtx fatty acid intracellular transport
ARACHDtr intracellular transport
ARGtiDF L-arginine transport via diffusion (extracellular to cytosol)
ARTFR12 R group artificial flux (C16:1)
ASCBt L-ascorbate transport via facilitated diffusion
ASNt4 L-asparagine transport in via sodium symport
Asn_X_Ser_Thrtr Asn-X-Ser/Thr transport (from ER to lysosome)
ASPGLUm aspartate-glutamate mitochondrial shuttle
ASPt6 L-aspartate transport via Na, H symport and K antiport
ATP1ter ADP/ATP transporter, endoplasmic reticulum
ATP2ter AMP/ATP transporter, endoplasmic reticulum
ATPasel V-type ATPase, H+ transporting, lysosomal
ATPtm ADP/ATP transporter, mitochondrial
BALAtmr Beta-alanine reversible mitochondrial transport (diffusion)
BHBt (R)-3-Hydroxybutanoate transport via H+ symport
BILGLCURtr glucuronidated compound transport
BILIRUBtr lipid, flip-flop intracellular transport
C226CRNt C226 transport into the mitochondria
CDPDAGtm intracellular transport
CERT1rt ceramide transport protein
CERT2rt ceramide transport protein
CHLtm choline transport via diffusion (cytosol to mitochondria)
CHOLATEt cholate transport via bicarbonate countertransport
CHOLATEt3 ABC bile acid transporter
CHSTEROLt2 cholesterol intracellular transport
CLOXAtex2 chloride transport via oxalate countertransport (2:1)
CLPNDt fatty acid transport via diffusion
CMPACNAtg CMP-Sia Golgi transport via CMP antiport
CMPACNAtn CMP-Sia nuclear export
CO2t CO2 transporter via diffusion
CO2ter CO2 endoplasmic reticular transport via diffusion
CO2tm CO2 transport (diffusion), mitochondrial
CO2tp CO2 peroxisomal transport
COAtm CoA transporter
COAtp coenzyme A transport, peroxisomal
COAtr COA transporter, endoplasmic reticulum
COt CO transporter via diffusion
CREATt4_2_r Creatine transport (sodium symport) (2:1)
CREATtmdiffir Creatine transport to/from mitochondria via diffusion
CRVNCtr fatty acid transport via diffusion
CTPtn CTP diffusion in nucleus
CYOOm2 cytochrome c oxidase, mitochondrial Complex IV
CYOR_u10m ubiquinol-6 cytochrome c reductase, Complex III
CYTDtm cytidine facilated transport in mitochondria
DAGt diacylglycerol transport
DATPtn dATP diffusion in nucleus
DCSPTN1CRNt transport into the mitochondria (carnitine)
DCSPTN1t fatty acid transport via diffusion
DCTPtn dCTP diffusion in nucleus
DGTPtn dGTP diffusion in nucleus
DHAAt1r dehydroascorbate transport (uniport)
DHFtl dihydrofolate reversible lysosomal transport
DHFtm dihydrofolate reversible mitochondrial transport
D_LACt2 D-lactate transport via proton symport
DLNLCGCRNt transport into the mitochondria (carnitine)
DNDPt1m dATP transport via ADP antiport
DNDPt27m dCDP transport via dTDP antiport
DNDPt29m dCDP transport via dADP antiport
DNDPt2m dATP transport via ATP antiport
DNDPt34m dGDP transport via dTDP antiport
DNDPt35m dGDP transport via dADP antiport
DNDPt37m dUTP transport via dTDP antiport
DNDPt39m dUTP transport via dGDP antiport
DNDPt40m dUTP transport via dADP antiport
DNDPt41m dUTP transport via dCDP antiport
DNDPt42m dUTP transport via ADP antiport
DNDPt43m dUTP transport via ATP antiport
DNDPt55m dCTP transport via ADP antiport
DNDPt56m dCTP transport via ATP antiport
DNDPt57m dGTP transport via ATP antiport
DNDPt58m dGTP transport via ADP antiport
DOLGLCP_Lter Dolichyl beta-D-glucosyl phosphate flippase (liver)
DOLMANP_Lter dolichol-phosphate mannose flippase (liver)
DOLP_Uter dolichol phosphate flippase (uterus)
DTDPtn dTDP nuclear transport
DTTPtn dTTP diffusion in nucleus
DUDPtn dUDP nuclear transport
DUMPtn dUMP nuclear transport
EICOSTETt fatty acid transport via diffusion
ETOHt ethanol reversible transport
ETOHtx ethanol reversible peroxisomal transport
F1Atg F1alpha transport (from golgi to lysosome)
FADH2tru FADH2 transporter, endoplasmic reticulum
FADtru FAD transporter, endoplasmic reticulum
FE2t iron (II) transport
FE2tm iron (II) transport
FORtr FOR transporter, endoplasmic reticulum
FRDPtr lipid, flip-flop intracellular transport
FUC14GALACGLCGALGLUSIDEte blood group intracellular transport
FUC14GALACGLCGALGLUSIDEtg blood group intracellular transport
FUCtly L-fucose efflux from lysosome
FUMSO3tm Fumarate:sulfite antiport, mitochondrial
FUMtm fumarate transport, mitochondrial
GALGLUSIDEtg galgluside hs intracellular transport
GALSIDEtl galactocerebroside intracellular transport
GALt1r galactose transport (uniport)
GALtly galactose efflux from lysosome
GAMt1r glucosamine transport (uniport)
GDPFUCtg GDPFuc Golgi transport via CMP antiport
GDPtg GDP intracellular transport
GGLUCT gamma-glutamylcyclotransferase
GLCMter glucose transport via membrane vesicle
GLCt4 glucose transport via sodium symport
GLCter glucose transport, endoplasmic reticulum
GLCtg glucose transport, Golgi apparatus
GLCURter glucuronate endoplasmic reticular transport
GLCURtly glucuronate transport into lysososme
GLNt4 L-glutamine reversible transport via sodium symport
GLNtm L-glutamine transport via electroneutral transporter
GLUt2m L-glutamate reversible transport via proton symport, mitochondrial
GLUt6 Glutamate transport via Na, H symport and K antiport
GLUt7l Glutamate transport, lysosomal
GLUtr intracellular transport
GLXtm glyoxylate transport, mitochondrial
GLXtp glyoxylate transport, peroxisomal
GLYBt4_2_r Betaine transport (sodium symport) (2:1)
GLYBtm Glycine betaine transport via diffusion (mitochondria to cytosol)
GLYCLTtp glycolate transport into peroxisome
GLYC_St L-glycerate export
GLYCtm glycerol transport
GLYt2r glycine reversible transport via proton symport
GLYt4 glycine transport via sodium symport
GLYtm glycine passive transport to mitochondria
GLYtp glycine passive transport to peroxisome
GMPtg GMP transport (Golgi)
GTHRDtr glutathione transport via diffusion
GULNter L-gulonate endoplasmic reticular export
H2O2t hydrogen peroxide transport via diffusion
H2O2tm hydrogen peroxide mitochondrial transport
H2O2tn hydrogen peroxide nuclear transport
H2O2tp hydrogen peroxide peroxisomal transport via diffusion
H2Ot H2O transport via diffusion
H2Oter H2O endoplasmic reticulum transport
H2Otg H2O transport, Golgi apparatus
H2Otly H2O transport, lysosomal
H2Otn H2O transport, nuclear
H2Otp H2O transport, peroxisomal
HAS1 hyaluronan synthase
HAS2 hyaluronan synthase
HAtly hyaluronan transport, extracellular to lysosome
HDD2COAtx hdd2coa intracellular transport
HISt4 L-histidine transport in via sodium symport
HMGCOAtm Hydroxymethylglutaryl-CoA reversible mitochondrial transport
HMGCOAtx Hydroxymethylglutaryl-CoA reversible peroxisomal transport
HOMt4 L-homoserine via sodium symport
HPYRtp hydroxypyruate transport, peroxisomal
Htg proton diffusion (Golgi)
Htm Uncoupling protein
Htr H transporter, endoplasmic reticulum
Htx H transporter, peroxisome
HXANtx hypoxanthine diffusion in peroxisome
INSTt4 inositol transport via sodium symport
IPDPtx Isopentenyl diphosphate transport (peroxisome)
KSII_CORE2t keratan sulfate II (core2) transport, golgi to extracellular
KSII_CORE2tly keratan sulfate II (core 2) transport, extracellular to lysosome
KSII_CORE4t keratan sulfate II (core4) transport, golgi to extracellular
KSII_CORE4tly keratan sulfate II (core 4) transport, extracellular to lysosome
KSIt keratan sulfate I transport, golgi to extracellular
KSItly keratan sulfate I transport, extracellular to lysosome
LEUKTRA4t leukotriene A4 transport
LEUKTRA4tr leukotriene intracellular transport
LEUKTRB4t leukotriene B4 transport
LEUKTRD4tr leukotriene intracellular transport
LEUKTRE4t leukotriene E4 transport
L_LACtm L-lactate transport, mitochondrial
LNLCCRNt transport into the mitochondria (carnitine)
LNLNCGCRNt transport into the mitochondria (carnitine)
LPCHOLt lysophosphatidylcholine transport
LYStiDF L-lysine transport via diffusion (extracellular to cytosol)
M4MPDOL_Uter m4mpdol flippase
M8MASNterg m8masn transport from ER to Golgi apparatus
MAGt monoacylglycerol 2 transport
MALSO3tm Malate:sulfite antiport, mitochondrial
MALtm malate transport, mitochondrial
MANt1r mannose transport (uniport)
MANtg mannose efflux from Golgi apparatus
MANtly mannose efflux from lysosome
MEOHt2 Methanol diffusion
N2M2NMASNt n2m2nmasn transport, Golgi to extracellular
N2M2NMASNtly n2m2nmasn transport, extracellular to lysosome
NADHtpu NADH transporter, peroxisome
NADHtru NADH transporter, endoplasmic reticulum
NADPHtru NADPH transporter, endoplasmic reticulum
NADPHtxu NADPH transporter, peroxisome
NADPtru NADP transporter, endoplasmic reticulum
NADPtxu NADP transporter, peroxisome
NADtru NAD transporter, endoplasmic reticulum
NaKt Na+/K+ exchanging ATPase
NAt sodium transport (uniport)
NAt3_1 sodium proton antiporter (H:NA is 1:1)
NH4tp ammonia peroxisomal transport
NKCC2t Na+-K+-Cl- cotransport (NH4+)
NKCCt Na+-K+-Cl- cotransport
NRVNCt fatty acid transport via diffusion
O2St superoxide anion transport via diffusion (extracellular)
O2Stm superoxide anion transport via diffusion (mitochondria)
O2Stn superoxide anion transport via diffusion (nucleus)
O2Stx superoxide anion transport via diffusion (peroxisome)
O2t o2 transport (diffusion)
O2ter O2 transport, endoplasmic reticulum
O2tm O2 transport (diffusion)
O2tn O2 nuclear transport
O2tp O2 transport, peroxisomal
OCCOAtm octanoyl(n-C8:0)-CoA transport
OCCOAtx fatty acid intracellular transport
OCTAt Octanoate transport via diffusion
ORNtiDF ornithine transport via diffusion (extracellular to cytosol)
OXAHCOtex oxalate transport via bicarbonate countertransport
PAIL_HStn phosphatidylinositol nuclear transport (diffusion)
PAIL45P_HStn phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
PAIL4P_HStn phosphatidylinositol 4-phosphate nuclear transport (diffusion)
PAPStg 3-Phosphoadenylyl sufate Golgi transport
PAPtg adenosine 3,5-bisphosphate Golgi transport
PCREATtmdiffir Phosphocreatine transport to/from mitochondria via diffusion
PE_HSter phosphatidylethanolamine scramblase
PE_HStm phosphatidylethanolamine scramblase
PEt phosphatidylethanolamine transport
PGLYCt phosphatidylglycerol transport
PHEMEtm Heme transport to cytosol
PHEt4 L-phenylalanine transport in via sodium symport
PIt2m phosphate transporter, mitochondrial
PItg phosphate transport, Golgi apparatus
PItn phosphate transport, nuclear
PItx Phosphate transporter, peroxisome
PPAt Propionate transport, diffusion
PPItr Diphosphate transporter, endoplasmic reticulum
PPItx Diphosphate transporter, peroxisome
PPPG9tm protoporphyrinogen IX mitochondrial transport
PRISTANALtx pristanal peroxisomal transport
PRISTtx prist peroxisomal transport
PROSTGH2t Prostaglandin H2 transport
PROSTGI2t Prostaglandin I2 transport
PROt2r L-proline reversible transport via proton symport
PROtm L-proline transport, mitochondrial
PSt3 phosphatidylserine transport
PYRt2m pyruvate mitochondrial transport via proton symport
PYRt2p pyruvate peroxisomal transport via proton symport
RETFAt fatty acid retinol efflux
RETNt retinoic acid transport
RETt retinol trasnport by STRA6
RTOTALt RTOTAL transport
Rtotaltl fatty acid intracellular transport
S2L2FN2M2MASNt s2l2fn2m2masn transport, Golgi to extracellular
S2L2FN2M2MASNtly s2l2fn2m2masn transport, extracellular to lysosome
S2L2N2M2MASNtly s2l2n2m2masn transport, extracellular to lysosome
SCP21x Sterol carrier protein 2
SCP22x Sterol carrier protein 2
Ser_Thrtg Ser/Thr transport (from golgi to lysosome)
SERt4 L-serine via sodium symport
SERtp L-serine transport, peroxisomal
SO4OXAtex2 sulfate transport via oxalate countertransport (2:1)
SO4tl Sulfate transport (lysosome)
SPC_HSt sphingosylphosphorylcholine transport (diffusion)
SPH1Pte sph1p transport
SPHINGStl sphingosine intracellular transport
SPHS1Pte sphingosine-1-phosphate transport
STRDNCt fatty acid transport via diffusion
SUCCt2m succinate transport, mitochondrial
TCHOLAt taurocholate transport via bicarbonate countertransport
TCHOLAte bile acid intracellular transport
THFtl 5,6,7,8-Tetrahydrofolate transport, diffusion, lysosomal
THFtm 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
THRt4 L-threonine via sodium symport
TMNDNCt fatty acid transport via diffusion
TRPt4 L-tryptophan transport in via sodium symport
UDPACGALtl udpacgal intracellular transport
UDPGALtg UDP-Gal Golgi transport via CMP antiport
UDPGLCAter UDPGlcA endoplasmic reticulum transport via UMP antiport
UDPGLCter UDP-Glc endoplasmic reticulum transport via CMP antiport
UDPtl udp intracellular transport
UGALNACtg UDP-GalNAc Golgi transport via CMP antiport
UGLCNACtg UDP-GlcNAc Golgi transport via CMP antiport
URATEt urate export from cytosol
URATEtx urate export from peroxisome
VACCt fatty acid transport via diffusion
WHHDCAte xenobiotic transport
XANtx xanthine diffusion in peroxisome
XOL27OHtm 27 hydroxy cholesterol transport
XOLDIOLONEt lipid, flip-flop intracellular transport
XYLTt Xylitol transport via passive diffusion
r0002 Active transport
r0801 Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
r0809 Facilitated diffusion
r0812 Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
r0818 Transport reaction
r0819 Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
r0821 Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
r0822 Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
r0830 Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
r0838 Free diffusion
r0853 Facilitated diffusion
r0860 Utilized transport
r0870 Facilitated diffusion
r0892 Facilitated diffusion
r0899 Amino acid transporter ATB0+ Facilitated diffusion
r0911 Facilitated diffusion
r0913 Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
r0917 Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
r0926 Postulated transport reaction
r0927 Free diffusion
r0940 Free diffusion
r0941 Free diffusion
r0942 Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
r0950 Facilitated diffusion
r0954 MCT 1 Transport reaction
r0973 Facilitated diffusion
r0990 Postulated transport reaction
r1000 Facilitated diffusion
r1004 Facilitated diffusion
r1007 Facilitated diffusion
r1010 Postulated transport reaction
r1013 Transport reaction
r1014 Postulated transport reaction
r1030 Transport reaction
r1088 Active transport
r1106 Postulated transport reaction
r1116 ATP Exporter (ATP-E) TCDB:9.A.6.1.1
r1117 Facilitated diffusion
r1143 Major Facilitator(MFS) TCDB:2.A.18.6.3
r1144 Major Facilitator(MFS) TCDB:2.A.18.6.3
r1147 Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
r1148 Active transport
r1162 Active transport
r1291 Postulated transport reaction
r1292 Postulated transport reaction
r1375 Transport reaction
r1400 Active transport
r1421 Free diffusion
r1434 Transport reaction
r1455 Transport reaction
r1456 Transport reaction
r1459 Transport reaction
r1464 Active transport
r1493 Utilized transport
r1515 ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
r1516 ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
r1522 ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
r1523 ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
r1531 ATP-binding Cassette (ABC) TCDB:3.A.1.208.15
r1532 ATP-binding Cassette (ABC) TCDB:3.A.1.208.15
r1546 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1547 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1556 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1560 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1561 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1570 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1573 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1574 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1583 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1585 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1586 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1595 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1598 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1602 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1603 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1606 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1633 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1640 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1646 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1651 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1655 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1658 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1660 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r1662 Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
r2084 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2093 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2099 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2101 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2102 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2103 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2104 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2105 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2107 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2108 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2114 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2119 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2123 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2128 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2132 Major Facilitator(MFS) TCDB:2.A.1.13.1
r2139 Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
r2151 Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
r2152 Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
r2353 Organic anion transporter 5 Utilized transport
r2368 Organic anion transporter 5 Utilized transport
r2369 Organic anion transporter 5 Utilized transport
r2372 Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
r2375 Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
r2419 Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
r2444 Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
r2472 Major Facilitator(MFS) TCDB:2.A.1.4.7
r2509 Utilized transport
r2517 ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
r2521 Utilized transport
r2537 Utilized transport
r2538 Utilized transport
PIt8 phosphate transport in/out via Na+ symporter
2MB2COAc transport of 2-methylcrotonoyl-CoA into cytosol
3HBCOARc transport of (R)-3-hydroxybutanoyl-CoA into cytosol
C141ACBP transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
C142ACBP transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
C142OHe excretion of C14:2-OH
C162ACBP transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
C6CRNe transport of hexanoyl carnitine into the extra cellular fluid
C8CRNe transport of octanoyl carnitine into the extra cellular space
DDCRNe transport of 3-hydroxydodecanoyl carnitine into extra cellular space
DDECCRNe transport of lauroyl carnitine into extra cellular space
DECCRNe transport of 3-hydroxydecanoyl carnitine into extra cellular space
GLUTCOAACBP transport of glutaryl-CoA(5-) from mitochondria into cytosol
HDCACBP transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
HDDACBP transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
HDECAACBP transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
HDECEACBP transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
HEXCOAACBP hexanoyl(n-C6:0)-CoA transport
HEXDIACTD transport of hexadecanedioc acid by diffusion
HEXDICOAACBP transport of hexadecanedioyl coa
HEXDICOAACBPx transport of hexadecanedioyl coa
HIVCACBP transport of 3-hydroxyisovalerylcoa from mitochondria into the cytosol
HIVCRNe transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
HOCDACBP transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
HOCTDACBP transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
HOCTDECCRNe transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
HTDCACBP transport of (S)-3-Hydroxytetradecanoyl-CoA from mitochondria into the cytosol
HTDCRNe transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
IVCOAACBP transport of Isovaleryl-CoA from mitochondria into cytosol
IVCRNe transport of isovaleryl carnitine into the extra cellular space
OCD11CRNCACT transport of 11-octadecenoyl carnitine into the mitochondrial matrix
OCTDEC2ACBP transport of 3-hydroxyoctadecadienoyl coa from mitochondria into cytosol
SUCCTD transport of succinate by diffusion
TIGCRNe transport of tiglyl carnitine into the extra cellular fluid
4OHPROIMINOtc transport of L-OH-Proline by the apical IMINO amino acid transporters in kidney and intestine
CARPEPT1tc transport of L-Carnosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
CYSPHELAT2tc transport of L-Cysteine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
ILELAT1tc transport of L-Isoleucine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
ILEPHELAT2tc transport of L-Isoleucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
LEUPHELAT2tc Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
LINOFATPtc uptake of linoleic acid by the enterocytes
NACDe release of nicotinate at the basolateral surface
SBTle diffusion of sorbitol into the enterocytes
THRPHELAT2tc transport of L-Threonine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
TRPATB0tc transport of L-Tryptophan into the intestinal cells by ATB0 transporter
TYRPHELAT2tc transport of L-Tyrosine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
VALLAT1tc transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
VALPHELAT2tc transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
AHCYStd diffusion of S-Adenosyl-L-homocysteine
AMETtd diffusion of S-Adenosyl-L-methionine
ASPDTDe D-aspartate transport, extracellular
CHSTEROLtrc transport of cholesterol into the cytosol
Coqe Transport of q10
DATPtm transport of dATP into mitochondria
DCTPtm transport of dCTP into mitochondria
DHAPtc transport of DHAP into cytosol
DTTPtm transport of dTTP into mitochondria
FE3MTP1 transport of ferrous iron into blood
GLYC3Ptmc glycerol-3-phopshate transport, cytoplasm
GLYCTDle difussion of glycerol accross the brush border membrane
KHte KHte
LACLt Lactate transport
NADtm transport of NAD into mitochondria
NADtx transport of NAD into peroxisome
PHEMEe release of heme into the blood
PPItm diphopshate transporter, mitochondrial
PRO_Dtde D-proline transport, extracellular
PTCRTD diffusion of putriscine into the endothelial cells
Q10H2e transport of ubiquinol into lymph
RTOTALFATPc uptake of Rtotal by enterocytes
SFCYSe Exit of sulfocysteine into extra-cellular space
SPMTDe SPMTDe
q10h2tc transport of ubiquinol into cytosol
q10tm transport of ubiquinone into mitochondria
3MOBte Transport of 3-methyl-2-oxobutanoate
3MOPte Transport of 3-methyl-2-oxopentanoate
4MOPte Transport of 4-methyl-2-oxopentanoate
5OXPROt Transport of 5-oxoprolinate
AHCYSte Transport of S-adenosyl-L-homocysteine
MAL_Lte Transport of L-malate
fumt Fumarate transport
xmpt Xanthosine 5-phosphate transport
dcmpt dCMP transport
HC00342te cis-aconitate transport
glyc3pte glycerol 3-phosphate transport
DM_Asn_X_Ser_Thr_ly_ DM Asn-X-Ser/Thr(ly)
DM_core5_g_ DM core5(g)
DM_core7_g_ DM core7(g)
DM_datp_m_ dATP demand
DM_datp_n_ DM datp(n)
DM_dctp_m_ dCTP demand
DM_dctp_n_ DM dctp(n)
DM_dgtp_m_ DM dgtp(m)
DM_dgtp_n_ DM dgtp(n)
DM_dttp_m_ dTTP demand
DM_dttp_n_ DM dttp(n)
DM_Ser_Thr_ly_ DM Ser/Thr(ly)
DM_sprm_c_ DM sprm(c)
DM_T_antigen_g_ DM T antigen(g)
sink_citr_LPAREN_c_RPAREN_ citrulline sink
DM_taur_LPAREN_c_RPAREN_ demand reaction for taurine
DM_pe_hs_LPAREN_r_RPAREN_ demand reaction for pe_hs[r]
DM_4hrpo Demand for trans-4-hydroxy-L-proline
DM_Lcystin Demand for L-cystine
DM_anth Demand for anthranilate
DM_ncam Demand for nicotinamide
EX_1mncam_LPAREN_e_RPAREN_ 1-Methylnicotinamide exchange
EX_abt_LPAREN_e_RPAREN_ L-Arabinitol exchange
EX_ac_LPAREN_e_RPAREN_ Acetate exchange
EX_acac_LPAREN_e_RPAREN_ Acetoacetate exchange
EX_acald_LPAREN_e_RPAREN_ Acetaldehyde exchange
EX_acetone_LPAREN_e_RPAREN_ Acetone exchange
EX_adn_LPAREN_e_RPAREN_ exchange reaction for Adenosine
EX_adrn_LPAREN_e_RPAREN_ adrenic acid exchange
EX_akg_LPAREN_e_RPAREN_ 2-Oxoglutarate exchange
EX_ala_B_LPAREN_e_RPAREN_ beta-Alanine exchange
EX_ala_L_LPAREN_e_RPAREN_ exchange reaction for L-alanine
EX_arab_L_LPAREN_e_RPAREN_ L-Arabinose exchange
EX_arg_L_LPAREN_e_RPAREN_ L-Arginine exchange
EX_ascb_L_LPAREN_e_RPAREN_ L-Ascorbate exchange
EX_asn_L_LPAREN_e_RPAREN_ exchange reaction for L-asparagine
EX_asp_D_LPAREN_e_RPAREN_ D-Aspartate exchange
EX_asp_L_LPAREN_e_RPAREN_ L-Aspartate exchange
EX_atp_LPAREN_e_RPAREN_ ATP exchange
EX_bhb_LPAREN_e_RPAREN_ (R)-3-Hydroxybutanoate transport via H+ symport
EX_bilglcur_LPAREN_e_RPAREN_ exchange reaction for blirubin mono-glucuronide
EX_cholate_LPAREN_e_RPAREN_ exchange reaction for cholate
EX_cit_LPAREN_e_RPAREN_ Citrate exchange
EX_CLPND_LPAREN_e_RPAREN_ clupanodonic acid (docosapentaenoic (n-3)) exchange
EX_cmp_LPAREN_e_RPAREN_ CMP exchange
EX_co_LPAREN_e_RPAREN_ Carbon monoxide exchange
EX_co2_LPAREN_e_RPAREN_ CO2 exchange
EX_creat_LPAREN_e_RPAREN_ Creatine exchange
EX_crn_LPAREN_e_RPAREN_ exchange reaction for L-Carnitine
EX_crvnc_LPAREN_e_RPAREN_ nC22:6 exchange
EX_cys_L_LPAREN_e_RPAREN_ exchange reaction for L-cysteine
EX_dag_hs_LPAREN_e_RPAREN_ exchange reaction for diglyceride
EX_dcsptn1_LPAREN_e_RPAREN_ docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
EX_dhdascb_LPAREN_e_RPAREN_ exchange reaction for dehydroascorbide(1-)
EX_eicostet_LPAREN_e_RPAREN_ eicosatetranoic acid exchange
EX_etoh_LPAREN_e_RPAREN_ Ethanol exchange
EX_fe2_LPAREN_e_RPAREN_ EX_fe2(u)
EX_fe3_LPAREN_e_RPAREN_ Fe3+ exchange
EX_for_LPAREN_e_RPAREN_ Formate exchange
EX_fuc14galacglcgalgluside_hs_LPAREN_e_RPAREN_ Lea glycolipid exchange
EX_fuc_L_LPAREN_e_RPAREN_ L-Fucose exchange
EX_gal_LPAREN_e_RPAREN_ exchange reaction for D-Galactose
EX_gam_LPAREN_e_RPAREN_ exchange reaction for D-Glucosamine
EX_glc_LPAREN_e_RPAREN_ D-Glucose exchange
EX_gln_L_LPAREN_e_RPAREN_ exchange reaction for L-glutamine
EX_gluala_LPAREN_e_RPAREN_ 5-L-Glutamyl-L-alanine exchange
EX_glu_L_LPAREN_e_RPAREN_ L-Glutamate exchange
EX_gly_LPAREN_e_RPAREN_ exchange reaction for Glycine
EX_glyb_LPAREN_e_RPAREN_ Glycine betaine exchange
EX_glyc_LPAREN_e_RPAREN_ Glycerol exchange
EX_glyc_S_LPAREN_e_RPAREN_ (S)-Glycerate exchange
EX_glygn2_LPAREN_e_RPAREN_ glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
EX_glygn4_LPAREN_e_RPAREN_ exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
EX_gthox_LPAREN_e_RPAREN_ Oxidized glutathione exchange
EX_gthrd_LPAREN_e_RPAREN_ Reduced glutathione exchange
EX_h_LPAREN_e_RPAREN_ exchange reaction for proton
EX_h2o_LPAREN_e_RPAREN_ H2O exchange
EX_h2o2_LPAREN_e_RPAREN_ Hydrogen peroxide exchange
EX_ha_LPAREN_e_RPAREN_ hyaluronan exchange
EX_ha_pre1_LPAREN_e_RPAREN_ hyaluronan biosynthesis, precursor 1 exchange
EX_hdca_LPAREN_e_RPAREN_ Hexadecanoate (n-C16:0) exchange
EX_hdcea_LPAREN_e_RPAREN_ exchange reaction for Hexadecenoate (n-C16:1)
EX_his_L_LPAREN_e_RPAREN_ exchange reaction for L-histidine
EX_ile_L_LPAREN_e_RPAREN_ L-Isoleucine exchange
EX_inost_LPAREN_e_RPAREN_ myo-Inositol exchange
EX_ins_LPAREN_e_RPAREN_ Inosine exchange
EX_lac_D_LPAREN_e_RPAREN_ D-lactate exchange
EX_lac_L_LPAREN_e_RPAREN_ L-Lactate exchange
EX_leuktrA4_LPAREN_e_RPAREN_ leukotriene A4 exchange
EX_leuktrB4_LPAREN_e_RPAREN_ leukotriene B4 exchange
EX_leuktrE4_LPAREN_e_RPAREN_ leukotriene E4 exchange
EX_leu_L_LPAREN_e_RPAREN_ L-Leucine exchange
EX_lnlc_LPAREN_e_RPAREN_ linoleic acid (all cis C18:2) exchange
EX_lpchol_hs_LPAREN_e_RPAREN_ exchange reaction for lysophosphatidylcholine
EX_lys_L_LPAREN_e_RPAREN_ L-Lysine exchange
EX_mag_hs_LPAREN_e_RPAREN_ Monoacylglycerol 2 (homo sapiens) exchange
EX_man_LPAREN_e_RPAREN_ exchange reaction for D-Mannose
EX_meoh_LPAREN_e_RPAREN_ methanol exchange
EX_met_L_LPAREN_e_RPAREN_ L-Methionine exchange
EX_n2m2nmasn_LPAREN_e_RPAREN_ N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
EX_nac_LPAREN_e_RPAREN_ Nicotinate exchange
EX_nh4_LPAREN_e_RPAREN_ Ammonia exchange
EX_nrvnc_LPAREN_e_RPAREN_ nervonic acid exchange
EX_o2_LPAREN_e_RPAREN_ exchange reaction for oxugen
EX_o2s_LPAREN_e_RPAREN_ Superoxide anion exchange
EX_ocdca_LPAREN_e_RPAREN_ echange reaction for octadecanoate (n-C18:0)
EX_ocdcea_LPAREN_e_RPAREN_ octadecenoate (n-C18:1) exchange
EX_octa_LPAREN_e_RPAREN_ exchange reaction for octanoate (n-C8:0)
EX_orn_LPAREN_e_RPAREN_ Ornithine exchange
EX_oxa_LPAREN_e_RPAREN_ Oxalate exchange
EX_pe_hs_LPAREN_e_RPAREN_ exchange reaction for phosphatidylethanolamine
EX_pglyc_hs_LPAREN_e_RPAREN_ phosphatidylglycerol (homo sapiens) exchange
EX_phe_L_LPAREN_e_RPAREN_ exchange reaction for L-phenylalanine
EX_pheme_LPAREN_e_RPAREN_ exchange reaction for heme
EX_pi_LPAREN_e_RPAREN_ Phosphate exchange
EX_ppa_LPAREN_e_RPAREN_ Propionate exchange
EX_pro_D_LPAREN_e_RPAREN_ D-Proline exchange
EX_pro_L_LPAREN_e_RPAREN_ L-Proline exchange
EX_ps_hs_LPAREN_e_RPAREN_ phosphatidylserine (homo sapiens) exchange
EX_pyr_LPAREN_e_RPAREN_ Pyruvate exchange
EX_retfa_LPAREN_e_RPAREN_ fatty acid retinol exchange
EX_retinol_LPAREN_e_RPAREN_ Retinol exchange
EX_retn_LPAREN_e_RPAREN_ Retinoate exchange
EX_ribflv_LPAREN_e_RPAREN_ exchange reaction for Riboflavin
EX_Rtotal_LPAREN_e_RPAREN_ R total exchange
EX_ser_L_LPAREN_e_RPAREN_ exchange reaction for L-serine
EX_so4_LPAREN_e_RPAREN_ Sulfate exchange
EX_spc_hs_LPAREN_e_RPAREN_ sphingosylphosphorylcholine (homo sapiens) exchange
EX_sph1p_LPAREN_e_RPAREN_ Sphinganine 1-phosphate exchange
EX_sphs1p_LPAREN_e_RPAREN_ Sphingosine 1-phosphate exchange
EX_strch1_LPAREN_e_RPAREN_ starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
EX_strch2_LPAREN_e_RPAREN_ exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
EX_strdnc_LPAREN_e_RPAREN_ stearidonic acid exchange
EX_thr_L_LPAREN_e_RPAREN_ L-Threonine exchange
EX_tmndnc_LPAREN_e_RPAREN_ timnodonic acid exchange
EX_trp_L_LPAREN_e_RPAREN_ L-Tryptophan exchange
EX_tyr_L_LPAREN_e_RPAREN_ L-Tyrosine exchange
EX_urate_LPAREN_e_RPAREN_ Urate exchange
EX_utp_LPAREN_e_RPAREN_ UTP exchange
EX_vacc_LPAREN_e_RPAREN_ vaccenic acid exchange
EX_val_L_LPAREN_e_RPAREN_ L-Valine exchange
EX_whhdca_LPAREN_e_RPAREN_ omega hydroxy hexadecanoate (n-C16:0) exchange
EX_xylt_LPAREN_e_RPAREN_ exchange reaction for xylitol
EX_ctp_LPAREN_e_RPAREN_ Exchange of CTP(4-)
EX_dtmp_LPAREN_e_RPAREN_ Exchange of dTMP(2-)
EX_dttp_LPAREN_e_RPAREN_ Exchange of dTTP(4-)
EX_fad_LPAREN_e_RPAREN_ Exchange of Flavin adenine dinucleotide oxidized
EX_fald_LPAREN_e_RPAREN_ Exchange of formaldehyde
EX_HC00250_LPAREN_e_RPAREN_ Exchange of hydrosulfide
EX_HC01609_LPAREN_e_RPAREN_ Exchange of UroporphyrinogenI
EX_HC01610_LPAREN_e_RPAREN_ Exchange of CoproporphyrinogenI
EX_ptrc_LPAREN_e_RPAREN_ Exchange of 1,4-butanediammonium
EX_spmd_LPAREN_e_RPAREN_ Exchange of spermidine(3+)
EX_prostgh2_LPAREN_e_RPAREN_ prostaglandin H2(1-) exchange
EX_C02470_LPAREN_e_RPAREN_ Xanthurenic acid exchange
EX_HC00822_LPAREN_e_RPAREN_ Chitobiose exchange
EX_ddca_LPAREN_e_RPAREN_ laurate exchange
EX_3ddcrn_ exchange reaction for 3-hydroxydodecanoyl carnitine
EX_3deccrn_ exchange reaction for 3-hydroxydecanoyl carnitine
EX_3ivcrn_ exchange reaction for 3-hydroxy-isovaleryl carnitine
EX_3octdeccrn_ exchange reaction for 3-hydroxyoctadecanoyl carnitine
EX_3tdcrn_ exchange reaction for 3-hydroxy-tetradecanoyl carnitine
EX_3ttetddcoacrn_ exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
EX_c51crn_ exchange reaction for tiglyl carnitine
EX_c6crn_ exchange reaction for hexanoyl carnitine
EX_c8crn_ exchange reaction for octanoyl carnitine
EX_ddecrn_ exchange reaction for lauroyl carnitine
EX_ivcrn_ exchange reaction for isovaleryl carnitine
EX_4hpro_LPAREN_e_RPAREN_ exchange reaction for hydroxy proline
EX_carn_LPAREN_e_RPAREN_ exchange reaction for carnosine
EX_sbt_DASH_d_LPAREN_e_RPAREN_ exchange reaction for D-Sorbitol
EX_sfcys_LPAREN_e_RPAREN_ exchange reaction for sulfocysteine
EX_fmn_LPAREN_e_RPAREN_ exchange reaction for FMN
EX_q10_LPAREN_e_RPAREN_ exchange reaction for ubiquinone
EX_q10h2_LPAREN_e_RPAREN_ exchange reaction for ubiquinol
EX_3mob_LPAREN_e_RPAREN_ Exchange of 3-methyl-2-oxobutanoate
EX_3mop_LPAREN_e_RPAREN_ Exchange of 3-methyl-2-oxopentanoate
EX_4mop_LPAREN_e_RPAREN_ Exchange of 4-methyl-2-oxopentanoate
EX_5oxpro_LPAREN_e_RPAREN_ Exchange of 5-oxoprolinate
EX_ahcys_LPAREN_e_RPAREN_ Exchange of S-adenosyl-L-homocysteine
EX_mal_L_LPAREN_e_RPAREN_ Exchange of L-malate
EX_fum_LPAREN_e_RPAREN_ Exchange of Fumarate
EX_xmp_LPAREN_e_RPAREN_ Exchange of Xanthosine 5-phosphate
EX_dcmp_LPAREN_e_RPAREN_ Exchange of dCMP
EX_HC00342_LPAREN_e_RPAREN_ exhange of cis-aconitate
EX_glyc3p_LPAREN_e_RPAREN_ exhange of glycerol 3-phosphate
biomass_reaction Generic human biomass reaction
biomass_protein protein component of biomass
biomass_DNA DNA component of biomass
biomass_RNA RNA component of biomass
biomass_carbohydrate carbohydrate component of biomass
biomass_lipid lipid component of biomass
biomass_other other component of biomass
BETBGTtc betaine transport by BGT
CRNATBtc carnitine transport by ATB0
H2OGLYAQPt water and glycerol transport by AQP
HDCAFAPMtc hexadecanoate transport by FAT
ILEB0AT2tc isoleucine transport by B0AT2
LEUB0AT2tc leucine transport by B0AT2
LGNCFATtc lignocerate transport by FAT
OCDCAFAPMtc octadecanoate tranport by FAT
PROB0AT2tc proline transport by B0AT2
VALB0AT2tc valine transport by B0AT2
3HPVSTETCOAhcm beta oxidation of 3''-S-hydroxy-pravastatin-CoA to tatranor-CoA derivative in hepatocytes, mitochondria
3HPVSTETtev exit of 3''-S-hydroxy-pravastatin-tetranor into hepatic vein
3HPVStep 3''-hydroxy pravastatin exit into portal blood
AM4N9CShc demethylation of AM9 to AM4N9 in hepatocytes
AM4N9CStev efflux of AM4N9-cyclosporine into hepatic vein
AM4NCShr demethylation of cyclosporine to AM4N in hepatocytes
AM4NCStep efflux of AM4N (cyclosporine) into portal blood
AM9CSAtep efflux of AM9 (cyclosporine) into portal blood
CRVSM1hr beta-glucuronidase of cerivastatin-M1-glucuronide to M1 form
CRVSM23hr beta-glucuronidase of cerivastatin-M23-glucuronide to M23 form
CSAtd uptake of cyclosporine by the enterocytes
CVM1GLUChc glucuronidation of cerivastatin-M1
CVM23GLUChc glucuronidation of cerivastatin-M23
EPOXTAChr formation of epoxy derivative of tacrolimus in hepatocytes
EPOXTACtev exit of 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus into hepatic vein
EX_3hpvs_LPAREN_e_RPAREN_ 3'-S-hydroxy-pravastatin exchange
EX_3hpvstet_LPAREN_e_RPAREN_ 3'-S-hydroxy-pravastatin-tetranor exchange
EX_am4n9cs_LPAREN_e_RPAREN_ AM4N9 (cyclosporine) exchange
EX_am4ncs_LPAREN_e_RPAREN_ AM4N (cyclosporine) exchange
EX_am9csa_LPAREN_e_RPAREN_ AM9 (cyclosporine) exchange
EX_csa_LPAREN_e_RPAREN_ cyclosporine exchange
EX_epoxtac_LPAREN_e_RPAREN_ 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus exchange
EX_tacr_LPAREN_e_RPAREN_ Tacrolimus exchange
SMVACIDhep beta-glucuronidation of simvastatin-acyl-glucuronide to simvastatin dihydroxy acid form
SMVGLUChep glucuronidation of the open acid form of simvastatin
TACRDtsc uptake of tacrolimus by enterocytes
TMDOATPtsc uptake of torasemide into enterocytes via antiport
TMDOATtev efflux of Torasemide into hepatic vein
TMDtd uptake of torasemide into enterocytes via diffusion
3HPVSCOAitm 3HPVSCOAitm
3HPVSTETCOAitm 3HPVSTETCOAitm
EPOXTACitr EPOXTACitr
TACRitr TACRitr
3HPVSCOAhc 3HPVSCOAhc
3HPVSTEThc 3HPVSTEThc
EX_hx_LPAREN_e_RPAREN_ exchange reaction for hexanoate (n-C6:0)
FACOAL120i fatty-acid--CoA ligase (dodecanoate, n-C12:0)
FACOAL60i fatty-acid--CoA ligase (hexanoate, n-C6:0)
HXt hexanoate transport via diffusion
AIRCr_PRASCS phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazolesuccinocarboxamide synthase
FAOXC10080x R_FAOXC10080x
FAOXC101_3Em R_FAOXC101_3Em
FAOXC101_4Zx R_FAOXC101_4Zx
FAOXC102_4Z_7Zm R_FAOXC102_4Z_7Zm
FAOXC120100m R_FAOXC120100m
FAOXC120100x R_FAOXC120100x
FAOXC122_3Z_6Zx R_FAOXC122_3Z_6Zx
FAOXC123_3Z_6Z_9Zm R_FAOXC123_3Z_6Z_9Zm
FAOXC140120x R_FAOXC140120x
FAOXC142_5Z_8Zx R_FAOXC142_5Z_8Zx
FAOXC143_5Z_8Z_11Zm R_FAOXC143_5Z_8Z_11Zm
FAOXC161140m R_FAOXC161140m
FAOXC163_4Z_7Z_10Zx R_FAOXC163_4Z_7Z_10Zx
FAOXC164_4Z_7Z_10Z_13Zm R_FAOXC164_4Z_7Z_10Z_13Zm
FAOXC184_3Z_6Z_9Z_12Zx R_FAOXC184_3Z_6Z_9Z_12Zx
FAOXC184_6Z_9Z_12Z_15Zm R_FAOXC184_6Z_9Z_12Z_15Zm
FAOXC185_3Z_6Z_9Z_12Z_15Zm R_FAOXC185_3Z_6Z_9Z_12Z_15Zm
FAOXC204_5Z_8Z_11Z_14Zx R_FAOXC204_5Z_8Z_11Z_14Zx
FAOXC205_5Z_8Z_11Z_14Z_17Zm R_FAOXC205_5Z_8Z_11Z_14Z_17Zm
FAOXC4020m R_FAOXC4020m
FAOXC61_3Zm R_FAOXC61_3Zm
FAOXC8060m R_FAOXC8060m
FAOXC81_5Zm R_FAOXC81_5Zm
import pandas as pd
df =
df.to_csv(index=False)---------------------------------------------------------------------------
ValueError Traceback (most recent call last)
<ipython-input-24-5004c5668cb6> in <module>()
2
3
----> 4 df = pd.DataFrame(scc_model.reactions.index)
5 df.to_csv(index=False)
/opt/conda/lib/python3.5/site-packages/pandas/core/frame.py in __init__(self, data, index, columns, dtype, copy)
352 copy=False)
353 else:
--> 354 raise ValueError('DataFrame constructor not properly called!')
355
356 NDFrame.__init__(self, mgr, fastpath=True)
ValueError: DataFrame constructor not properly called!
list = ["RE2319R", "C141ACBP", "TYRTAm", "HDCACBP", "DPGM", "RE1635R", "3HBCOARc", "FAEL184", "GLXO1", "r0173", "FBA2", "r0570", "NaKt", "EHGLATm", "RE3401M", "OCDCAFAPMtc", "MCLOR", "NTD5", "SFGTH", "ARGtiDF", "SERt4", "r0801", "r0358", "r0354", "biomass_RNA", "HDECAACBP", "RE3386M", "PPM", "ORNtiDF", "NTD8", "ECOAH12m", "PGK", "NT5C", "GLNt4", "RE3587N", "HTDCACBP", "NTD4", "RE1818R", "FBA4", "RE3110C", "RE3192M", "RE3120C", "GTHPm", "FAEL204", "GTHPe", "C162ACBP", "3SALATAim", "NTD6", "ACITL", "r0047", "ALAt4", "RE3398M", "HOCDACBP", "RE1520M", "biomass_carbohydrate", "ECOAH1m", "DM_atp_c_", "ALCD21_L", "PMANM", "r0575", "IMPD", "HEXCOAACBP", "SPODM", "biomass_lipid", "biomass_protein", "r0407", "RE2514C", "RE3344M", "ADK3m", "HIVCACBP", "r0360", "SPODMx", "RE3390M", "RE3241C", "RE3563M", "PPA", "2MB2COAc", "RE3248M", "r0739", "r0170", "HEX10", "GALU", "HEX1", "RE0565C", "RE3225C", "r0361", "SPODMn", "HDCAFAPMtc", "IVCOAACBP", "LYStiDF", "LALDO", "RE1816R", "HDDACBP", "RDH1a", "DUTPDPn", "NTD7", "EHGLAT2m", "RE1521M", "RE3194M", "ENO", "NTD10", "C4STMO1r", "NTD1", "NTD3", "2HBO", "34DHOXPEGOX", "RE1062M", "NADKm", "RE3241R", "OCTDEC2ACBP", "PHETA1m", "RE2920M", "r0355", "RE3521R", "ATPtm", "PRPNCOAHYDm", "HISt4", "NTD9", "r0656", "RAI3", "r0357", "ASPTAm", "MDHm", "ASNt4", "HOMt4", "RE3532R", "HEX4", "DUTPDPm", "RE3447M", "r0364", "FBA", "SQLSr", "LDH_L", "RE3557R", "GLYt4", "ALCD1", "RE3496N", "NTD2", "RE2514L", "GLUTCOAACBP", "RE3193M", "FAEL183", "RE3533R", "PRDX", "HDECEACBP", "LTC4Sr", "PHEt4", "LCYSTATm", "LGTHL", "RE3004M", "RE3224C", "HEXDICOAACBPx", "biomass_DNA", "CYSTAm", "r1378", "RE1523M", "RE2919M", "biomass_other", "PGM", "ALCD22_L", "RE3226C", "r0604", "PGMT", "RE2318R", "NTD11", "C142ACBP", "DASCBR", "RE3554R", "r0363", "GTHP", "r0009", "HOCTDACBP", "FALDH", "PIt2m", "ECOAH9m", "RE3534R", "H2OGLYAQPt", "THRt4", "RE1522M", "HEXDICOAACBP", "SLDxm", "MDH", "RE3337M", "HPYRR2x", "LDH_Lm", "RE1815R", "RE1817R", "C4STMO2r", "LGNCFATtc", "HEX7", "biomass_reaction", "GAPD", "CSm", "ALCD2if", "TPI", "SLDx", "r0660", "FAEL205", "GALNTg", "RE2921M", "DPGase"]for rx in list:
print(Recon2.reactions.get_by_id(rx).gene_reaction_rule)HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:2690
HGNC:11573 or HGNC:4433
HGNC:2690
HGNC:1093 or HGNC:8888 or HGNC:8889
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:2690
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:19708 or HGNC:21481 or HGNC:28335 or HGNC:30866 or (HGNC:6535 and HGNC:6541) or HGNC:6535 or HGNC:6541 or HGNC:6544
HGNC:6535 or HGNC:6541
HGNC:414 or HGNC:417 or HGNC:418
HGNC:8906
(HGNC:14073 and HGNC:804) or (HGNC:14073 and HGNC:808) or (HGNC:799 and HGNC:804) or (HGNC:799 and HGNC:805) or (HGNC:799 and HGNC:806) or (HGNC:799 and HGNC:808) or (HGNC:800 and HGNC:804) or (HGNC:800 and HGNC:805) or (HGNC:800 and HGNC:808) or (HGNC:801 and HGNC:804) or (HGNC:801 and HGNC:805)
HGNC:4433
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:1663 or HGNC:4433
HGNC:21481 or HGNC:28335 or HGNC:30866 or (HGNC:6535 and HGNC:6541) or HGNC:6535 or HGNC:6541 or HGNC:6544
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:3465
HGNC:11057 or HGNC:11060 or HGNC:11061 or HGNC:14679
HGNC:11047 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:10992
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:2690
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:8905 or HGNC:8906
HGNC:11057 or HGNC:11060 or HGNC:11061
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:3151 or (HGNC:4801 and HGNC:4803)
HGNC:8896 or HGNC:8898
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:11047 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:16049
HGNC:2690
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:414 or HGNC:417 or HGNC:418
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:4553 or HGNC:4556 or HGNC:9354
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:4553 or HGNC:4554 or HGNC:4555 or HGNC:4558 or HGNC:4559
HGNC:2690
HGNC:4433
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:115
HGNC:15769 or HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:17819 or HGNC:38831 or HGNC:8021 or HGNC:8022
HGNC:11047 or HGNC:11057 or HGNC:11060 or HGNC:11061 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:2690
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:3151 or (HGNC:4801 and HGNC:4803) or HGNC:890
HGNC:16354 or (HGNC:249 and HGNC:250) or (HGNC:249 and HGNC:251) or HGNC:249 or (HGNC:250 and HGNC:251) or HGNC:250 or HGNC:251 or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256 or HGNC:28697
HGNC:8906 or HGNC:9114 or HGNC:9115
HGNC:3629
HGNC:6052 or HGNC:6053
HGNC:2690
HGNC:11179
HGNC:414 or HGNC:417 or HGNC:418
HGNC:12015 or HGNC:16753
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:17376
HGNC:2690
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:11179
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:30042 or HGNC:9226
HGNC:2690
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
(HGNC:249 and HGNC:250 and HGNC:251) or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256
HGNC:3629
HGNC:23302 or HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:12527 or HGNC:12527
HGNC:23302 or HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:11179
HGNC:1663 or HGNC:4433
HGNC:2690
HGNC:11057 or HGNC:11060 or HGNC:11061 or HGNC:14679
HGNC:253
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:2690
HGNC:14423 or HGNC:17964 or HGNC:19975 or HGNC:19977 or HGNC:19978 or HGNC:19979 or HGNC:30311
HGNC:3078
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8022
HGNC:4433
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:3350 or HGNC:3354 or HGNC:3354 or HGNC:3353
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:10545
HGNC:17144 or HGNC:17820
HGNC:17144 or HGNC:17818 or HGNC:17820 or HGNC:4678 or HGNC:8021
HGNC:21481 or HGNC:28335 or HGNC:30866 or (HGNC:6535 and HGNC:6541) or HGNC:6535 or HGNC:6541 or HGNC:6544
HGNC:16354 or (HGNC:249 and HGNC:250) or (HGNC:249 and HGNC:251) or (HGNC:250 and HGNC:251) or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256
HGNC:16058
HGNC:26404
HGNC:14416 or HGNC:14418 or HGNC:15829 or HGNC:21308
HGNC:2690
HGNC:11573 or HGNC:4433
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:10990 or HGNC:10991 or HGNC:10992
HGNC:3151 or HGNC:3247 or (HGNC:4801 and HGNC:4803) or HGNC:890
HGNC:11047 or HGNC:13448
HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:2698
HGNC:4632 or HGNC:4632 or HGNC:4638 or HGNC:4626
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:4433
HGNC:6970 or HGNC:6971
HGNC:11047 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:11057 or HGNC:11060 or HGNC:11061
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:23302 or HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:3078 or HGNC:6176
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:414 or HGNC:417 or HGNC:418
HGNC:3629
HGNC:21481 or HGNC:28335 or HGNC:30866 or (HGNC:6535 and HGNC:6541) or HGNC:6535 or HGNC:6541 or HGNC:6544
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:11047 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:16354 or (HGNC:249 and HGNC:250) or (HGNC:249 and HGNC:251) or HGNC:249 or (HGNC:250 and HGNC:251) or HGNC:250 or HGNC:251 or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256 or HGNC:28697
HGNC:16049
HGNC:17820
HGNC:16753 or HGNC:7218
HGNC:2690
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:16753 or HGNC:3423
HGNC:2690
HGNC:6719 or HGNC:7063 or HGNC:7064
HGNC:11047 or HGNC:11057 or HGNC:11060 or HGNC:11061 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or HGNC:14679 or (HGNC:27960 and HGNC:29437)
HGNC:4433
HGNC:4323
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:2690
HGNC:4433
HGNC:253
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:1093 or HGNC:8888 or HGNC:8889
HGNC:16354 or (HGNC:249 and HGNC:250) or (HGNC:249 and HGNC:251) or HGNC:249 or (HGNC:250 and HGNC:251) or HGNC:250 or HGNC:251 or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256 or HGNC:28697
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:2698
HGNC:8905 or HGNC:8906
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:17818 or HGNC:17820 or HGNC:8021 or HGNC:8022
HGNC:2690
HGNC:16065 or HGNC:4330 or HGNC:13312
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:4553 or HGNC:4554 or HGNC:4556 or HGNC:9352 or HGNC:9353
HGNC:28883 or HGNC:30042 or HGNC:9226
HGNC:2690
HGNC:253
HGNC:10989
HGNC:3151 or (HGNC:4801 and HGNC:4803)
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:16029 or HGNC:636 or HGNC:640 or HGNC:643
HGNC:11047 or HGNC:13447 or HGNC:13448 or (HGNC:13557 and HGNC:27960) or (HGNC:27960 and HGNC:29437)
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:2690
HGNC:6971
HGNC:17836 or HGNC:6970
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:19708 or HGNC:21481 or HGNC:28335 or (HGNC:6535 and HGNC:6541) or HGNC:6535 or HGNC:6541 or HGNC:6544
HGNC:19708 or HGNC:6535 or HGNC:6541
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:7061 or HGNC:7063 or HGNC:7064
HGNC:10545 or HGNC:13398
HGNC:1663 or HGNC:4433
HGNC:23302 or HGNC:4195 or HGNC:4922 or HGNC:4923 or HGNC:4925
HGNC:24864 or HGNC:4141
HGNC:2422
HGNC:16354 or (HGNC:249 and HGNC:250) or (HGNC:249 and HGNC:251) or HGNC:249 or (HGNC:250 and HGNC:251) or HGNC:250 or HGNC:251 or HGNC:252 or HGNC:253 or HGNC:255 or HGNC:256 or HGNC:28697
HGNC:12009
HGNC:17836 or HGNC:6970
(HGNC:4801 and HGNC:4803) or HGNC:3151
HGNC:14415 or HGNC:14416 or HGNC:15829 or HGNC:21308
HGNC:19873 or HGNC:19875 or HGNC:19877 or HGNC:21531 or HGNC:22946 or HGNC:23242 or HGNC:4123 or HGNC:4124 or HGNC:4125 or HGNC:4126 or HGNC:4127 or HGNC:4128 or HGNC:4129 or HGNC:4130 or HGNC:4131
HGNC:3151 or HGNC:3247 or HGNC:4801 or HGNC:4803
HGNC:1093 or HGNC:8888 or HGNC:8889
Recon2.metabolites.HC00250_e.name'hydrosulfide'
Recon2.reactions.PSSA1_hs.gene_reaction_rule'HGNC:9587'
#Biomass bounds
for rxex in hela_model.exchanges:
rxex.bounds=(-0.01,1)
#### AminoAcids
hela_model.reactions.EX_ala_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_arg_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_asn_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_asp_L_LPAREN_e_RPAREN_.lower_bound=-1
#hela_model.reactions.EX_cys_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_gln_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_glu_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_gly_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_his_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_ile_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_leu_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_lys_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_met_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_phe_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_pro_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_ser_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_thr_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_trp_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_tyr_L_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_val_L_LPAREN_e_RPAREN_.lower_bound=-1
### DMEM 6429 medium
#Carbon Sources
hela_model.reactions.EX_glc_LPAREN_e_RPAREN_.lower_bound=-4.5
hela_model.reactions.EX_pyr_LPAREN_e_RPAREN_.lower_bound= -1
### DMEM 6429 medium
#Minerals, vitamins, other
hela_model.reactions.EX_chol_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_fe2_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_fol_LPAREN_e_RPAREN_.lower_single_gene_deletionbound=-1
hela_model.reactions.EX_h2o_LPAREN_e_RPAREN_.lower_bound=-10
hela_model.reactions.EX_inost_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_pi_LPAREN_e_RPAREN_.lower_bound=-10
hela_model.reactions.EX_pydxn_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_ribflv_LPAREN_e_RPAREN_.lower_bound=-1
hela_model.reactions.EX_so4_LPAREN_e_RPAREN_.lower_bound=-1
#EXTRA
hela_model.reactions.EX_o2_LPAREN_e_RPAREN_.bounds=(-1000,0)
hela_model.reactions.biomass_reaction.bounds=(0.0,1000)#Biomass bounds
for rxex in hacat_model.exchanges:
rxex.bounds=(-0.01,1)
### DMEM 6429 medium
#### AminoAcids
hacat_model.reactions.EX_ala_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_arg_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_asn_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_asp_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_cys_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_gln_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_glu_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_gly_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_his_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_ile_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_leu_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_lys_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_met_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_phe_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_pro_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_ser_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_thr_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_trp_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_tyr_L_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_val_L_LPAREN_e_RPAREN_.lower_bound=-1
### DMEM 6429 medium
#Carbon Sources
hacat_model.reactions.EX_glc_LPAREN_e_RPAREN_.lower_bound=-4.5
hacat_model.reactions.EX_pyr_LPAREN_e_RPAREN_.lower_bound= -1
### DMEM 6429 medium
#Minerals, vitamins, other
hacat_model.reactions.EX_chol_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_fe2_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_fol_LPAREN_e_RPAREN_.lower_single_gene_deletionbound=-1
hacat_model.reactions.EX_h2o_LPAREN_e_RPAREN_.lower_bound=-10
#h2s
hacat_model.reactions.EX_inost_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_pi_LPAREN_e_RPAREN_.lower_bound=-10
hacat_model.reactions.EX_ribflv_LPAREN_e_RPAREN_.lower_bound=-1
hacat_model.reactions.EX_so4_LPAREN_e_RPAREN_.lower_bound=-1
#EXTRA
hacat_model.reactions.EX_o2_LPAREN_e_RPAREN_.bounds=(-1000,0)
hacat_model.reactions.biomass_reaction.lower_bound=0.000
hacat_model.reactions.biomass_reaction.upper_bound=1000hela_fba = hela_model.optimize()
hacat_fba = hacat_model.optimize()For each flux in HeLa we reduce the flux to 0.001 and check infleasible fluxes
import pandas as pd
def get_drugable_targets(normal_Model, disease_Model, eps=0.001):
Nids = [r.id for r in normal_Model.reactions]
Dids = [r.id for r in disease_Model.reactions]
nmodel=normal_Model.copy()
dmodel=disease_Model.copy()
common_rxs = list(set(Nids) & set(Dids))
print("Common reactions size",len(common_rxs))
unique_Nrx = list(set(Nids) - set(Dids))
print("Normal unique reactions size",len(unique_Nrx))
unique_Drx = list(set(Dids) - set(Nids))
print("Disease unique reactions size",len(unique_Drx))
nflx0=normal_Model.optimize().f
dflx0=disease_Model.optimize().f
results={}
for rx in common_rxs:
print(rx)
nbounds=nmodel.reactions.get_by_id(rx).bounds
dbounds=dmodel.reactions.get_by_id(rx).bounds
nmodel.reactions.get_by_id(rx).bounds=(-eps,eps)
dmodel.reactions.get_by_id(rx).bounds=(-eps,eps)
nflx1=nmodel.optimize().f
dflx1=dmodel.optimize().f
results[rx]={}
results[rx]["norm_flux"]=nflx1
results[rx]["dise_flux"]=dflx1
results[rx]["norm_prolif_ratio"]=nflx1/nflx0
results[rx]["dise_prolif_ratio"]=dflx1/dflx0
results[rx]["norm_dise_ratio"]=(nflx1/nflx0)/(dflx1/dflx0)
nmodel.reactions.get_by_id(rx).bounds=nbounds
dmodel.reactions.get_by_id(rx).bounds=dbounds
for rx in unique_Nrx:
print(rx)
nbounds=nmodel.reactions.get_by_id(rx).bounds
nmodel.reactions.get_by_id(rx).bounds=(-eps,eps)
nflx1=nmodel.optimize().f
results[rx]={}
results[rx]["norm_flux"]=nflx1
results[rx]["dise_flux"]=dflx0
results[rx]["norm_prolif_ratio"]=nflx1/nflx0
results[rx]["dise_prolif_ratio"]=dflx0
results[rx]["norm_dise_ratio"]=nflx1/nflx0
nmodel.reactions.get_by_id(rx).bounds=nbounds
for rx in unique_Drx:
print(rx)
dbounds=dmodel.reactions.get_by_id(rx).bounds
dmodel.reactions.get_by_id(rx).bounds=(-eps,eps)
dflx1=dmodel.optimize().f
results[rx]={}
results[rx]["norm_flux"]=nflx0
results[rx]["dise_flux"]=dflx1
results[rx]["norm_prolif_ratio"]=nflx0
results[rx]["dise_prolif_ratio"]=dflx1/dflx0
results[rx]["norm_dise_ratio"]=1/(dflx1/dflx0)
dmodel.reactions.get_by_id(rx).bounds=dbounds
return(pd.DataFrame(results).transpose())
R=get_drugable_targets(hacat_model, hela_model)---------------------------------------------------------------------------
NameError Traceback (most recent call last)
<ipython-input-5-272e3856561b> in <module>()
----> 1 R=get_drugable_targets(hacat_model, hela_model)
NameError: name 'hacat_model' is not defined
R[R["dise_prolif_ratio"]< 1 ].sort_values(by="norm_dise_ratio", ascending=False)---------------------------------------------------------------------------
NameError Traceback (most recent call last)
<ipython-input-3-78e08c28ed6e> in <module>()
----> 1 R[ R["dise_prolif_ratio"]< 1 ].sort_values(by="norm_dise_ratio", ascending=False)
NameError: name 'R' is not defined
hela_model.reactions.PMEVKc.gene_reaction_rule---------------------------------------------------------------------------
NameError Traceback (most recent call last)
<ipython-input-6-1554ae659e02> in <module>()
----> 1 hela_model.genes.get_by_id("HGNC:9068")
NameError: name 'hela_model' is not defined
%matplotlib inline
import seaborn as sns
import matplotlib.pyplot as plt
import numpy as np
from matplotlib.colors import ListedColormap
R["FoldChange"]=np.log2(R["norm_dise_ratio"])
#sns.boxplot(x="FoldChange", data=R, )
plt.scatter( np.log2(R["dise_prolif_ratio"]) ,np.log2(R["norm_prolif_ratio"]))<matplotlib.collections.PathCollection at 0x7f6f84dd7278>
import pandas as pd
f1=cobra.flux_analysis.pfba(hela_model).fluxes
f2=cobra.flux_analysis.pfba(hacat_model).fluxes
f1=hela_model.optimize().fluxes
f2=hacat_model.optimize().fluxes
df=pd.DataFrame(dict(hela_model = f1, hacat_model = f2)).reset_index() df.to_csv("fba_hela_hacat_fluxes.csv", header=True)
<style>
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text-align: right;
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}
| index | hacat_model | hela_model | |
|---|---|---|---|
| 0 | 13DAMPPOX | 0.000000e+00 | 0.000000e+00 |
| 1 | 1PPDCRp | 0.000000e+00 | 0.000000e+00 |
| 2 | 2AMADPTm | 0.000000e+00 | 0.000000e+00 |
| 3 | 2DR1PP | NaN | 0.000000e+00 |
| 4 | 2HBO | NaN | 0.000000e+00 |
| 5 | 2HBt2 | NaN | 0.000000e+00 |
| 6 | 2MB2COAc | 0.000000e+00 | 4.695740e-03 |
| 7 | 2MCITt | 0.000000e+00 | NaN |
| 8 | 2OXOADOXm | 0.000000e+00 | 0.000000e+00 |
| 9 | 2OXOADPTm | 0.000000e+00 | 0.000000e+00 |
| 10 | 34DHOXPEGOX | 0.000000e+00 | 0.000000e+00 |
| 11 | 34HPPte | 0.000000e+00 | 0.000000e+00 |
| 12 | 3AIBTm | NaN | 0.000000e+00 |
| 13 | 3AIB_Dtm | 0.000000e+00 | NaN |
| 14 | 3AIBt | NaN | 0.000000e+00 |
| 15 | 3AIBtm | NaN | 0.000000e+00 |
| 16 | 3HAO | 0.000000e+00 | NaN |
| 17 | 3HBCDm | 0.000000e+00 | NaN |
| 18 | 3HBCOAHLm | 0.000000e+00 | 0.000000e+00 |
| 19 | 3HBCOARc | 0.000000e+00 | 0.000000e+00 |
| 20 | 3HCO3_NAt | 0.000000e+00 | 0.000000e+00 |
| 21 | 3MLDAt | 0.000000e+00 | 0.000000e+00 |
| 22 | 3MOBt2im | 0.000000e+00 | 0.000000e+00 |
| 23 | 3MOBte | 0.000000e+00 | 0.000000e+00 |
| 24 | 3MOPt2im | 0.000000e+00 | 0.000000e+00 |
| 25 | 3MOPte | 0.000000e+00 | 0.000000e+00 |
| 26 | 4ABUTtcn | 0.000000e+00 | 0.000000e+00 |
| 27 | 4HOXPACDOX_NADP_ | 0.000000e+00 | 0.000000e+00 |
| 28 | 4MOPt2im | 0.000000e+00 | 0.000000e+00 |
| 29 | 4MOPte | 0.000000e+00 | 0.000000e+00 |
| ... | ... | ... | ... |
| 2767 | r2433 | 0.000000e+00 | 2.725616e-03 |
| 2768 | r2438 | 0.000000e+00 | 0.000000e+00 |
| 2769 | r2444 | NaN | 1.000000e-02 |
| 2770 | r2447 | 0.000000e+00 | 1.000000e-02 |
| 2771 | r2449 | 0.000000e+00 | 1.000000e-02 |
| 2772 | r2471 | 0.000000e+00 | 0.000000e+00 |
| 2773 | r2472 | 0.000000e+00 | 0.000000e+00 |
| 2774 | r2473 | 0.000000e+00 | 0.000000e+00 |
| 2775 | r2493 | 0.000000e+00 | NaN |
| 2776 | r2495 | NaN | 0.000000e+00 |
| 2777 | r2502 | 0.000000e+00 | 0.000000e+00 |
| 2778 | r2505 | 0.000000e+00 | 0.000000e+00 |
| 2779 | r2506 | 0.000000e+00 | NaN |
| 2780 | r2508 | 0.000000e+00 | NaN |
| 2781 | r2509 | 0.000000e+00 | 0.000000e+00 |
| 2782 | r2511 | 0.000000e+00 | 0.000000e+00 |
| 2783 | r2514 | -1.509674e-03 | -2.121704e-03 |
| 2784 | r2516 | 0.000000e+00 | 0.000000e+00 |
| 2785 | r2517 | 0.000000e+00 | 0.000000e+00 |
| 2786 | r2518 | 0.000000e+00 | 0.000000e+00 |
| 2787 | r2520 | NaN | 0.000000e+00 |
| 2788 | r2521 | 0.000000e+00 | 0.000000e+00 |
| 2789 | r2525 | 0.000000e+00 | 0.000000e+00 |
| 2790 | r2526 | 0.000000e+00 | 4.071467e-02 |
| 2791 | r2532 | 0.000000e+00 | 0.000000e+00 |
| 2792 | r2534 | 0.000000e+00 | -1.402281e-02 |
| 2793 | r2537 | 0.000000e+00 | 0.000000e+00 |
| 2794 | sink_citr_LPAREN_c_RPAREN_ | 0.000000e+00 | 0.000000e+00 |
| 2795 | sink_octdececoa_LPAREN_c_RPAREN_ | -3.469447e-18 | 7.285839e-17 |
| 2796 | xmpt | 1.000000e-02 | 1.000000e-02 |
2797 rows × 3 columns