diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 98a77112d..f1c140e0d 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -185,13 +185,6 @@ jobs:
           os: ${{ matrix.os }}
           python-version: ${{ matrix.python-version }}
         if: ${{ matrix.python-version != '3.11' && (matrix.os != 'windows-2019' || (matrix.os == 'windows-2019' && matrix.python-version != '3.11')) }}
-      - name: Install PyQuante2
-        run: |
-          source "$CONDA/etc/profile.d/conda.sh"
-          conda activate psi4env
-          conda install -y pyquante2_pure -c rpmuller
-        shell: bash
-        if: ${{ matrix.python-version != '3.11' }}
       - uses: ./.github/actions/install-main-dependencies
         with:
           os: ${{ matrix.os }}
@@ -257,7 +250,7 @@ jobs:
         with:
           name: ${{ matrix.os }}-${{ matrix.python-version }}
           path: ./ci-artifact-data/*
-      - name: Nature Unit Tests without matplotlib/pyscf/psi4/pyquante2/sparse/opt_einsum under Python ${{ matrix.python-version }}
+      - name: Nature Unit Tests without matplotlib/pyscf/psi4/sparse/opt_einsum under Python ${{ matrix.python-version }}
         env:
           PYTHONWARNINGS: default
         run: |
@@ -268,11 +261,6 @@ jobs:
               echo 'Uninstall psi4'
               conda remove -y --force psi4
           fi
-          echo 'Uninstall pyquante2'
-          if [[ "${{ matrix.python-version }}" != "3.11" ]]; then
-            conda remove -y --force pyquante2_pure
-          fi
-          pip uninstall -y pyquante2
           if [ "${{ github.event_name }}" == "schedule" ] || [ "${{ contains(github.event.pull_request.labels.*.name, 'run_slow') }}" == "true" ]; then
               export QISKIT_TESTS="run_slow"
           fi
diff --git a/qiskit_nature/optionals.py b/qiskit_nature/optionals.py
index 128dfc68a..5120325d2 100644
--- a/qiskit_nature/optionals.py
+++ b/qiskit_nature/optionals.py
@@ -1,6 +1,6 @@
 # This code is part of Qiskit.
 #
-# (C) Copyright IBM 2022.
+# (C) Copyright IBM 2022, 2023.
 #
 # This code is licensed under the Apache License, Version 2.0. You may
 # obtain a copy of this license in the LICENSE.txt file in the root directory
@@ -53,12 +53,6 @@ def _is_available(self):
         return super()._is_available() if self._run else True
 
 
-HAS_PYQUANTE2 = LazyImportTester(
-    "pyquante2",
-    name="pyquante2",
-    msg="See https://github.com/rpmuller/pyquante2",
-)
-
 HAS_PYSCF = LazyImportTester(
     "pyscf",
     name="pyscf",