diff --git a/docs/index.html b/docs/index.html index 265f96a28..744db7ba2 100644 --- a/docs/index.html +++ b/docs/index.html @@ -91,25 +91,25 @@

Summary

Number of Nodes
-
4962
+
5339
Number of Edges
-
16621
+
18422
Number of Citations
-
317
+
337
Number of Authors
-
1781
+
1892
Network Density
-
6.75E-04
+
6.46E-04
Number of Components
31
Number of Warnings
-
28
+
58
@@ -337,126 +337,459 @@

Statements

- pmid:29196815 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases bp(GO:"positive regulation of neuron apoptotic process") + a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis") - pmid:29196815 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle") + a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress") - pmid:29196815 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis) + a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress") - pmid:29196815 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") + a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") - pmid:18650430 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") + a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") - pmid:21214928 + pmid:19293145 - a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") + act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process") - pmid:21214928 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") + a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade") - pmid:21214928 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027) + a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway") - pmid:21214928 + pmid:28745240 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pmid:28745240 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pmid:28745240 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex") - pmid:22122372 + pmid:28745240 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pmid:28745240 - a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pmid:25652642 - a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918)) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases p(HGNC:TNF) + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) + + + + + + + pmid:28019679 + + a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases p(HGNC:APP) + + + + + + + pmid:18930136 + + a(CHEBI:"amyloid-beta") association deg(p(HGNC:APP)) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") regulates act(p(FPLX:PKC)) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway") + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + + + + + + + pmid:19293145 + + a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + + + + + + + pmid:19293145 + + act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + + + + + + + pmid:19293145 + + act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + + + + + + + pmid:19293145 + + act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + + + + + + + pmid:24590577 + + a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + + + + + + + pmid:21882945 + + a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases a(CHEBI:"calcium(2+)") + + + + + + + pmid:28745240 + + a(CHEBI:"amyloid-beta") increases act(a(MESH:Microglia)) + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases bp(GO:"glial cell activation") + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") + + + + + + + pmid:16566606 + + a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL1B)) + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL6)) + + + + + + + pmid:29179999 + + a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + + + + + + + pmid:27288790 + + a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + + + + + + + pmid:27288790 + + a(CHEBI:"amyloid-beta") increases act(p(HGNC:NFKB1)) + + + + + + + pmid:27288790 + + a(CHEBI:"amyloid-beta") increases act(p(HGNC:RELA)) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") increases act(p(HGNC:APOE)) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") @@ -490,9 +823,81 @@

Statements

- pmid:21214928 + pmid:25652642 - a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade") + a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) + + + + + + + pmid:19293145 + + a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) + + + + + + + pmid:19293145 + + a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX)) + + + + + + + pmid:25652642 + + a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins") + + + + + + + pmid:29196815 + + a(CHEBI:"amyloid-beta") increases bp(GO:"positive regulation of neuron apoptotic process") + + + + + + + pmid:29196815 + + a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle") + + + + + + + pmid:29196815 + + a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis) + + + + + + + pmid:29196815 + + a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") + + + + + + + pmid:18650430 + + a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") @@ -501,7 +906,7 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") @@ -510,16 +915,16 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) + a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") - pmid:19293145 + pmid:21214928 - a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) + a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027) @@ -528,34 +933,34 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:memory) + a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") - pmid:25514383 + pmid:21214928 - a(CHEBI:"amyloid-beta") increases bp(GO:memory) + a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") - pmid:29758300 + pmid:22122372 - sec(a(CHEBI:"amyloid-beta")) increases bp(GO:memory) + a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") - pmid:22908190 + pmid:22122372 - a(CHEBI:"amyloid-beta") decreases bp(GO:memory) + a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") @@ -564,16 +969,16 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") + a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") - pmid:21214928 + pmid:22122372 - a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation") + a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") @@ -582,7 +987,7 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") + a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade") @@ -591,7 +996,7 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") increases bp(GO:"cell death") + a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade") @@ -600,7 +1005,16 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) + + + + + + + pmid:19293145 + + a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) @@ -609,7 +1023,34 @@

Statements

pmid:21214928 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") decreases bp(GO:memory) + + + + + + + pmid:25514383 + + a(CHEBI:"amyloid-beta") increases bp(GO:memory) + + + + + + + pmid:29758300 + + sec(a(CHEBI:"amyloid-beta")) increases bp(GO:memory) + + + + + + + pmid:22908190 + + a(CHEBI:"amyloid-beta") decreases bp(GO:memory) @@ -618,7 +1059,7 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") @@ -627,7 +1068,7 @@

Statements

pmid:21214928 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation") @@ -636,7 +1077,7 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") @@ -645,7 +1086,7 @@

Statements

pmid:21214928 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:"amyloid-beta") increases bp(GO:"cell death") @@ -654,88 +1095,88 @@

Statements

pmid:21214928 - a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester") + a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:22122372 + pmid:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory") + sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:22122372 + pmid:21214928 - a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038) + a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:22122372 + pmid:21214928 - a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018) + sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:19293145 + pmid:21214928 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:19293145 + pmid:21214928 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:19293145 + pmid:21214928 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester") - pmid:19293145 + pmid:22122372 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory") - pmid:24590577 + pmid:22122372 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038) - pmid:21882945 + pmid:22122372 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018) @@ -1019,24 +1460,6 @@

Statements

- - - pmid:19293145 - - a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) - - - - - - - pmid:19293145 - - a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX)) - - - - pmid:19293145 @@ -1055,15 +1478,6 @@

Statements

- - - pmid:19293145 - - act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process") - - - - pmid:19293145 @@ -1406,6 +1820,78 @@

Statements

+ + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases bp(GO:locomotion) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") decreases path(MESH:Anxiety) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") decreases path(MESH:"Interpersonal Relations") + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases p(HGNC:AIF1) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases p(HGNC:PTPRC) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases p(HGNC:STAT3, pmod(Ph)) + + + + + + + pmid:26010758 + + a(CHEBI:"amyloid-beta") increases r(HGNC:BACE1) + + + + + + + pmid:12428809 + + a(CHEBI:"amyloid-beta") association bp(GO:"axonal transport") + + + + pmid:29758300 @@ -1514,15 +2000,6 @@

Statements

- - - pmid:18930136 - - a(CHEBI:"amyloid-beta") association deg(p(HGNC:APP)) - - - - pmid:24027553 @@ -1685,15 +2162,6 @@

Statements

- - - pmid:16566606 - - a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") - - - - pmid:29221819 @@ -1820,15 +2288,6 @@

Statements

- - - pmid:28019679 - - a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) - - - - pmid:28019679 @@ -2009,6 +2468,60 @@

Statements

+ + + pmid:28745240 + + act(a(MESH:Microglia)) increases p(HGNC:TNF) + + + + + + + pmid:28745240 + + act(a(MESH:Microglia)) increases p(HGNC:IL1B) + + + + + + + pmid:28745240 + + act(a(MESH:Microglia)) increases p(HGNC:IL6) + + + + + + + pmid:28745240 + + act(a(MESH:Microglia)) increases p(HGNC:CXCL8) + + + + + + + pmid:28745240 + + act(a(MESH:Microglia)) increases bp(GO:"neuron death") + + + + + + + pmid:25652642 + + act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + + + + pmid:23178521 @@ -2423,6 +2936,402 @@

Statements

+ + + pmid:21329555 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BACE1) + + + + + + + pmid:21329555 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) + + + + + + + pmid:21329555 + + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + + + + + + + pmid:24027553 + + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + + + + + + + pmid:28745240 + + path(MESH:"Alzheimer Disease") association p(HGNC:IL6) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) + + + + + + + pmid:28745240 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + + + + + + + pmid:29179999 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB)) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity") + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species") + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + + + + + + + pmid:24561250 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + + + + + + + pmid:27314526 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + + + + + + + pmid:24561250 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + + + + + + + pmid:27314526 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + + + + + + + pmid:27314526 + + path(MESH:"Alzheimer Disease") association p(HGNC:IL18) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1) + + + + + + + pmid:22020111 + + path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade") + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:GLAP) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2) + + + + + + + pmid:22020111 + + path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2) + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-146a") + + + + + + + pmid:27288790 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-155") + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:"MIR9-1") + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) + + + + + + + pmid:25652642 + + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) + + + + pmid:30444369 @@ -4538,6 +5447,15 @@

Statements

+ + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) + + + + pmid:22020111 @@ -4772,15 +5690,6 @@

Statements

- - - pmid:22020111 - - path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1) - - - - pmid:22020111 @@ -5136,7 +6045,7 @@

Statements

pmid:22020111 - path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2) + path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9) @@ -5145,7 +6054,7 @@

Statements

pmid:22020111 - path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9) + path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1) @@ -5154,7 +6063,7 @@

Statements

pmid:22020111 - path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1) @@ -5163,16 +6072,61 @@

Statements

pmid:22020111 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") - pmid:22020111 + pmid:23454242 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") + path(MESH:"Alzheimer Disease") increases p(HGNC:SET) + + + + + + + pmid:24653673 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) + + + + + + + pmid:23454242 + + path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) @@ -5249,6 +6203,15 @@

Statements

+ + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) + + + + pmid:24653673 @@ -5287,9 +6250,9 @@

Statements

- pmid:24653673 + pmid:22299660 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) @@ -5298,7 +6261,7 @@

Statements

pmid:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) @@ -5307,7 +6270,7 @@

Statements

pmid:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) @@ -5316,7 +6279,7 @@

Statements

pmid:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) @@ -5325,7 +6288,7 @@

Statements

pmid:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") @@ -5352,7 +6315,7 @@

Statements

pmid:24653673 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) @@ -5564,6 +6527,276 @@

Statements

+ + + pmid:12428809 + + path(MESH:"Alzheimer Disease") association a(HBP:"straight filaments") + + + + + + + pmid:12428809 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:26631930 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:12428809 + + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") + + + + + + + pmid:22908190 + + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") + + + + + + + pmid:12428809 + + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + + + + + + + pmid:21882945 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 189)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + + + + + + + pmid:26458742 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:29191965 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:22419736 + + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:28420982 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:26458742 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:22419736 + + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:26458742 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:29191965 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:26751493 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:29758300 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:26751493 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(Me, Leu, 309)) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT) + + + + + + + pmid:22299660 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) + + + + pmid:25437566 @@ -5897,24 +7130,6 @@

Statements

- - - pmid:29758300 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - - - - - - - pmid:26751493 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - - - - pmid:29758300 @@ -6140,15 +7355,6 @@

Statements

- - - pmid:22908190 - - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") - - - - pmid:25784053 @@ -6356,15 +7562,6 @@

Statements

- - - pmid:24027553 - - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) - - - - pmid:24027553 @@ -6644,15 +7841,6 @@

Statements

- - - pmid:21882945 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - - - - pmid:21882945 @@ -6689,51 +7877,6 @@

Statements

- - - pmid:22419736 - - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - - - - - - - pmid:28420982 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - - - - - - - pmid:26458742 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - - - - - - - pmid:22419736 - - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - - - - - - - pmid:26458742 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) - - - - pmid:22419736 @@ -6743,33 +7886,6 @@

Statements

- - - pmid:29191965 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) - - - - - - - pmid:26751493 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) - - - - - - - pmid:29191965 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - - - - pmid:29191965 @@ -7112,15 +8228,6 @@

Statements

- - - pmid:26458742 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) - - - - pmid:26195256 @@ -7391,15 +8498,6 @@

Statements

- - - pmid:26631930 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") - - - - pmid:26631930 @@ -7895,51 +8993,6 @@

Statements

- - - pmid:24561250 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - - - - - - - pmid:27314526 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - - - - - - - pmid:24561250 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) - - - - - - - pmid:27314526 - - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) - - - - - - - pmid:27314526 - - path(MESH:"Alzheimer Disease") association p(HGNC:IL18) - - - - pmid:24561250 @@ -8246,6 +9299,33 @@

Statements

+ + + pmid:23454242 + + bp(GO:aging) increases p(HGNC:PPP2R2C) + + + + + + + pmid:23454242 + + bp(GO:aging) decreases p(HGNC:PPP2R2B) + + + + + + + pmid:28083634 + + bp(GO:aging) increases p(MGI:Otub1) + + + + pmid:27491084 @@ -9578,6 +10658,24 @@

Statements

+ + + pmid:30106381 + + bp(GO:memory) association p(HGNC:ADNP) + + + + + + + pmid:30106381 + + bp(GO:memory) association a(PUBCHEM:9832404) + + + + pmid:22908190 @@ -10316,6 +11414,24 @@

Statements

+ + + pmid:30106381 + + bp(GO:learning) association p(HGNC:ADNP) + + + + + + + pmid:30106381 + + bp(GO:learning) association a(PUBCHEM:9832404) + + + + pmid:22908190 @@ -10523,6 +11639,33 @@

Statements

+ + + pmid:27288790 + + bp(GO:"immune response") association m(MIRBASE:"hsa-mir-146a") + + + + + + + pmid:30106381 + + bp(GO:"immune response") association p(HGNC:ADNP) + + + + + + + pmid:30106381 + + bp(GO:"immune response") association a(PUBCHEM:9832404) + + + + pmid:23746257 @@ -10541,6 +11684,15 @@

Statements

+ + + pmid:29179999 + + bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB)) + + + + pmid:27522251 @@ -10658,6 +11810,24 @@

Statements

+ + + pmid:30106381 + + bp(GO:"cell adhesion") association p(HGNC:ADNP) + + + + + + + pmid:30106381 + + bp(GO:"cell adhesion") association a(PUBCHEM:9832404) + + + + pmid:30046111 @@ -10846,9 +12016,18 @@

Statements

- pmid:22040696 + pmid:21329555 - path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") + path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:27288790 + + path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") @@ -10862,6 +12041,42 @@

Statements

+ + + pmid:21329555 + + path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") + + + + + + + pmid:27288790 + + path(MESH:Inflammation) association p(FPLX:NFkappaB) + + + + + + + pmid:22040696 + + path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") + + + + + + + pmid:30106381 + + path(MESH:Inflammation) association p(HGNC:ADNP) + + + + pmid:24027553 @@ -11209,6 +12424,33 @@

Statements

+ + + pmid:12428809 + + p(HGNC:APP) association bp(GO:"axonal transport") + + + + + + + pmid:12428809 + + sec(p(HGNC:APP)) association bp(GO:"regulation of neuronal synaptic plasticity") + + + + + + + pmid:12428809 + + sec(p(HGNC:APP)) association bp(GO:"negative regulation of neuron apoptotic process") + + + + @@ -13461,6 +14703,24 @@

Statements

+ + + pmid:28745240 + + bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:28745240 + + bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) + + + + @@ -13606,6 +14866,15 @@

Statements

+ + + pmid:21329555 + + p(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + pmid:30444369 @@ -14100,6 +15369,33 @@

Statements

+ + + pmid:28745240 + + p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pmid:28745240 + + p(HBP:"sAPP-alpha") increases bp(GO:neurogenesis) + + + + + + + pmid:25652642 + + p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + + + + @@ -14113,6 +15409,8 @@

Statements

+ + pmid:19293145 @@ -14180,6 +15478,24 @@

Statements

+ + + pmid:12428809 + + p(HGNC:MAPT) association bp(GO:"axonal transport") + + + + + + + pmid:12428809 + + p(HGNC:MAPT) increases bp(GO:"axonal transport") + + + + pmid:21734277 @@ -14336,6 +15652,25 @@

Statements

+ + + + + + + + + pmid:10391244 + + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + + pmid:19277525 @@ -14345,17 +15680,67 @@

Statements

+ + + pmid:12428809 + + p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization") + + - pmid:10391244 + pmid:12428809 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") + + + + + + + pmid:12428809 + + p(HGNC:MAPT) increases bp(GO:"axon development") + + + + + + + + + + + + + + + + + + + pmid:25378699 + + deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + + + + + + + pmid:24905733 + + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ub)) + + + + pmid:29758300 @@ -14464,8 +15849,6 @@

Statements

- - pmid:29758300 @@ -14569,26 +15952,6 @@

Statements

- - - - - pmid:25378699 - - deg(p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) - - - - - - - pmid:24905733 - - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ub)) - - - - pmid:22908190 @@ -14631,8 +15994,6 @@

Statements

- - pmid:30145931 @@ -14664,12 +16025,6 @@

Statements

- - - - - - pmid:30116051 @@ -14881,8 +16236,6 @@

Statements

- - pmid:29590627 @@ -15142,8 +16495,6 @@

Statements

- - pmid:21882945 @@ -15213,8 +16564,6 @@

Statements

- - pmid:25374103 @@ -15554,10 +16903,6 @@

Statements

- - - - pmid:26631930 @@ -17409,2067 +18754,2142 @@

Statements

- pmid:30444369 + pmid:25681350 - a(CHEBI:tacrine) increases bp(GO:cognition) + a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") - pmid:30444369 + pmid:25681350 - a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) + a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") - pmid:19293145 + pmid:25681350 - a(CHEBI:tacrine) increases p(HGNC:BCL2) + r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") - pmid:19293145 + pmid:25681350 - act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) + r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") - pmid:24511233 + pmid:25681350 - a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") - pmid:11230871 + pmid:25681350 - a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) + r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") - pmid:11230871 + pmid:25681350 - a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") - pmid:11230871 + pmid:25681350 - a(CHEBI:tacrine) increases p(FPLX:CHRN) + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha") - pmid:30444369 + pmid:25681350 - a(CHEBI:donepezil) increases bp(GO:cognition) + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6") + + - pmid:26813123 + pmid:25681350 - a(CHEBI:donepezil) increases bp(GO:cognition) + p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") - pmid:30444369 + pmid:25681350 - a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) + p(MGI:"interleukin 1 alpha") increases p(MGI:"signal transducer and activator of transcription 3") - pmid:19126755 + pmid:25681350 - a(CHEBI:donepezil) decreases p(HGNC:ACHE) + p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:11230871 + pmid:25681350 - a(CHEBI:donepezil) increases act(p(HGNC:ACHE)) + p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") + p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) + p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) + p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) increases p(HGNC:CHRNA4) + p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) increases p(HGNC:CHRNA7) + p(MGI:"interleukin 1 alpha") regulates p(MGI:"chitinase-like 1") - pmid:19293145 + pmid:25681350 - a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) + p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") - pmid:19293145 + pmid:28745240 - a(CHEBI:donepezil) increases p(HGNC:BCL2) + complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") - pmid:24511233 + pmid:28745240 - a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") - pmid:18986241 + pmid:25652642 - a(CHEBI:donepezil) increases act(a(MESH:D005625)) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") - pmid:29626319 + pmid:28745240 - a(CHEBI:donepezil) increases p(HGNC:ABCB1) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:29626319 + pmid:28745240 - a(CHEBI:donepezil) increases p(HGNC:LRP1) + complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") - pmid:29626319 + pmid:28745240 - a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta") + complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") - pmid:30444369 + pmid:28745240 - a(CHEBI:rivastigmine) increases bp(GO:cognition) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:30444369 + pmid:25652642 - a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:19126755 + pmid:28745240 - a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) + complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") - pmid:11230871 + pmid:25652642 - a(CHEBI:rivastigmine) increases act(p(HGNC:ACHE)) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") - pmid:19293145 + pmid:28745240 - a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) - pmid:19293145 + pmid:28745240 - a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) - pmid:26813123 + pmid:28745240 - a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") - pmid:19293145 + pmid:25652642 - a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity) + act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") - pmid:19293145 + pmid:28745240 - a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(GO:"NF-kappaB complex") increases bp(GO:memory) - pmid:24511233 + pmid:28745240 - a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + complex(GO:"NF-kappaB complex") increases bp(GO:learning) - pmid:29626319 + pmid:28745240 - a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) + complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) - pmid:29626319 + pmid:28745240 - a(CHEBI:rivastigmine) increases p(HGNC:LRP1) + complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) - pmid:29626319 + pmid:28745240 - a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta") + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) - pmid:30444369 + pmid:28745240 - a(CHEBI:galanthamine) increases bp(GO:cognition) + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) - pmid:26813123 + pmid:28745240 - a(CHEBI:galanthamine) increases bp(GO:cognition) + complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) - pmid:30444369 + pmid:28745240 - a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) + complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") - pmid:19126755 + pmid:28745240 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") - pmid:19126755 + pmid:25652642 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") - pmid:19126755 + pmid:25652642 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") - pmid:19126755 + pmid:28745240 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) - pmid:19293145 + pmid:28745240 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) - pmid:19126755 + pmid:28745240 - a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration) + act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) - pmid:19126755 + pmid:28745240 - a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") + act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) - pmid:19126755 + pmid:28745240 - a(CHEBI:galanthamine) decreases p(HGNC:ACHE) + act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) - pmid:11230871 + pmid:25652642 - a(CHEBI:galanthamine) increases act(p(HGNC:ACHE)) + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) - pmid:19293145 + pmid:28745240 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration)) - pmid:19293145 + pmid:28745240 - a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:19293145 + pmid:28745240 - act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:19293145 + pmid:28745240 - a(CHEBI:galanthamine) increases p(HGNC:BCL2) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:24511233 + pmid:28745240 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") - pmid:17009926 + pmid:28745240 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") - pmid:17009926 + pmid:28745240 - a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") - pmid:26813123 + pmid:28745240 - a(CHEBI:galanthamine) decreases path(MESH:Death) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:25881725 + pmid:28745240 - a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:25881725 + pmid:28745240 - a(CHEBI:galanthamine) increases bp(GO:learning) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:25881725 + pmid:28745240 - a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:25881725 + pmid:25652642 - a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:25881725 + pmid:28745240 - a(CHEBI:galanthamine) increases p(MGI:Chrna7) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") - pmid:25881725 + pmid:28745240 - a(CHEBI:galanthamine) increases p(MGI:Chrna7) + complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) - pmid:19721446 + pmid:28745240 - a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) + complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) - pmid:19721446 + pmid:28745240 - a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") - pmid:30444369 + pmid:28745240 - a(CHEBI:memantine) increases bp(GO:cognition) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:30444369 + pmid:28745240 - a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:19293145 + pmid:28745240 - a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:19293145 + pmid:28745240 - a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:23722080 + pmid:28745240 - a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) - pmid:26813123 + pmid:28745240 - a(CHEBI:memantine) decreases a(HBP:Excitotoxicity) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") - pmid:16273023 + pmid:28745240 - a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) + complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1) - pmid:16273023 + pmid:28745240 - a(CHEBI:memantine) causesNoChange bp(MESH:D009435) + complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) - pmid:23722080 + pmid:28745240 - a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) - pmid:23722080 + pmid:28745240 - a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) - pmid:23722080 + pmid:28745240 - a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") + complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) - pmid:19126755 + pmid:28745240 - act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) + act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") + + + pmid:28745240 + + act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") + + - pmid:24511233 + pmid:28745240 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") + act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1) - pmid:24511233 + pmid:28745240 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) + act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5) - pmid:30444369 + pmid:28745240 - g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) - pmid:29196815 + pmid:28745240 - g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) - pmid:26195256 + pmid:28745240 - g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) - pmid:30444369 + pmid:28745240 - g(HGNC:APP, var("?")) increases p(HGNC:MAPT) + complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) - pmid:30116051 + pmid:28745240 - g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) - pmid:30116051 + pmid:28745240 - g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) - pmid:30116051 + pmid:28745240 - g(HGNC:APP, var("?")) increases a(HBP:HBP00081) + complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) + + + pmid:28745240 + + complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) + + - pmid:30444369 + pmid:28745240 - g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - pmid:29758300 + pmid:25652642 - g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) - pmid:30444369 + pmid:28745240 - g(HBP:"APOE e4") decreases deg(p(HGNC:APP)) + complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:29758300 + pmid:28745240 - g(HBP:"APOE e4") increases bp(GO:"cholesterol metabolic process") + complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:29758300 + pmid:28745240 - g(HBP:"APOE e4") regulates deg(a(CHEBI:"amyloid-beta")) + complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") increases act(a(CHEBI:"amyloid-beta")) + complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") regulates bp(GO:"cholesterol transport") + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:22908190 + pmid:25652642 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta")) - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis) + act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta") - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") increases a(GO:endosome) + complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") - pmid:22908190 + pmid:28745240 - g(HBP:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") - pmid:22908190 + pmid:25652642 - g(HBP:"APOE e4") increases path(HBP:Neurodegeneration) + act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta") - pmid:22908190 + pmid:25652642 - g(HBP:"APOE e4") increases bp(GO:"apoptotic process") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:30444369 + pmid:28745240 - g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) - pmid:29196815 + pmid:28745240 - g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) - pmid:30116051 + pmid:25652642 - g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) - pmid:26195256 + pmid:25652642 - g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) - pmid:30116051 + pmid:21958873 - g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) + complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) - pmid:30116051 + pmid:25331948 - g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) + complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) - pmid:30116051 + pmid:28745240 - g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) + complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing") + + + pmid:25652642 + + act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing") + + - pmid:30444369 + pmid:25652642 - g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing") - pmid:29196815 + pmid:28745240 - g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates p(HBP:C99) - pmid:26195256 + pmid:28745240 - g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) - + + + pmid:28745240 + + complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) + - + + + pmid:28745240 + + complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) + - pmid:29196815 + pmid:28745240 - a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) - pmid:19293145 + pmid:28745240 - a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) - pmid:26195256 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) - pmid:19126755 + pmid:28745240 - a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") - pmid:19126755 + pmid:28745240 - a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) - pmid:19293145 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") - pmid:19126755 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) + act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") - pmid:19126755 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:19126755 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:19126755 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") - pmid:19126755 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") + complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) + complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) + complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) + act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") - pmid:25514383 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19721446 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19721446 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(HBP:neurotoxicity) + act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) - pmid:22908190 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) - pmid:19721446 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) - pmid:19721446 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) - pmid:14556719 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils") + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) - pmid:22908190 + pmid:25652642 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) - pmid:22908190 + pmid:25652642 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(HBP:"APOE e4") + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) - pmid:22908190 + pmid:25652642 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity) - pmid:22908190 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation a(CHEBI:"amyloid-beta") + complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1") - pmid:26195256 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta") + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) - pmid:30116051 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) - pmid:30116051 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) - pmid:30116051 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) - pmid:30116051 + pmid:25652642 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) - pmid:30116051 + pmid:21958873 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") + complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) - pmid:30116051 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) + p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1") - pmid:30116051 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) + p(MGI:"signal transducer and activator of transcription 3") increases p(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) + p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:AK1) + act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) + act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNC:AK1)) + p(MGI:"oncostatin M") increases complex(GO:"NF-kappaB complex") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:Tauopathies) + p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MGI:"oncostatin M") increases path(MESH:Glioblastoma) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(HGNC:AK3) + p(MGI:"oncostatin M") regulates p(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) + p(MGI:"oncostatin M") increases p(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph)) + p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 171)) + p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(ECCODE:"2.7.11.31") + p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") - pmid:22419736 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph)) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") - pmid:29626319 + pmid:25681350 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases p(MGI:"chemokine (C-X-C motif) ligand 15") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) + p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) + p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + p(MGI:"chitinase-like 1") association p(MGI:"reticuloendotheliosis oncogene") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + p(MGI:"chitinase-like 1") association p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) + p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) - pmid:22908190 + pmid:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M")) + + - pmid:30444369 + pmid:25681350 - p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") - pmid:30444369 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") increases path(HBP:"mitochondrial dysfunction") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") - pmid:30444369 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") - pmid:30444369 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:CSNK1A1) + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1") - pmid:19293145 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) - pmid:24590577 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M")) - pmid:25514383 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") - pmid:22817713 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1") - pmid:24511233 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) - pmid:24590577 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M")) - pmid:17009926 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7) + p(MGI:"reticuloendotheliosis oncogene") association p(MGI:"chitinase-like 1") - pmid:27491084 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB1) + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") association p(MGI:"chitinase-like 1") - pmid:27491084 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:CRYAB) + p(HGNC:IL1A) increases p(HGNC:RELB) - pmid:27491084 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB6) + p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) - pmid:27491084 + pmid:25681350 - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) + p(HGNC:IL1A) causesNoChange r(HGNC:RELB) - pmid:28877763 + pmid:28745240 - a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) + act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") - pmid:28877763 + pmid:23702978 - a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) + p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) - pmid:28877763 + pmid:23702978 - a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) + p(HGNC:IL1A) increases bp(GO:"inflammatory response") - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") + p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1) - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") + p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP) + p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") + p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) + + + + - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta") + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates p(MGI:"chitinase-like 1") - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases p(MGI:"chitinase-like 1") - pmid:29758300 + pmid:25681350 - path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + + + pmid:25681350 + + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + + + + + pmid:21718217 + + r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:30444369 + pmid:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) + p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) - pmid:30444369 + pmid:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") + p(HGNC:OSM) causesNoChange r(HGNC:RELB) - pmid:30444369 + pmid:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") + p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1) - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") + p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pmid:25652642 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") + p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") + p(HGNC:RELA) increases r(HGNC:BACE1) - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") + p(HGNC:RELA) increases p(HGNC:BACE1) - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) + p(HGNC:RELA) increases p(HBP:C99) - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) + p(HGNC:RELA) causesNoChange p(HGNC:APP) - pmid:30444369 + pmid:21329555 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") + p(HGNC:RELA) increases a(CHEBI:"amyloid-beta") - pmid:30444369 + pmid:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) + p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") - pmid:30444369 + pmid:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) + p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") - pmid:30444369 + pmid:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") + p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") - pmid:30444369 + pmid:27288790 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) + act(p(HGNC:RELA)) increases bp(GO:"apoptotic process") + + + + + + - pmid:30444369 + pmid:27288790 - p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process") - pmid:30444369 + pmid:25681350 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) + p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1) - pmid:30444369 + pmid:28745240 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) + p(HGNC:STAT3) increases bp(GO:"astrocyte development") + + - pmid:30444369 + pmid:19293145 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) + act(p(HGNC:STAT3)) association p(HGNC:JAK2) - pmid:30444369 + pmid:19293145 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) + act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine)) - pmid:30444369 + pmid:30116051 - act(p(HGNC:HSD17B10)) association p(FPLX:GABR) + p(HGNC:STAT3) decreases bp(GO:macroautophagy) + + + pmid:25681350 + + path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1") + + + + + pmid:25681350 + + path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") + + @@ -19484,19 +20904,14 @@

Statements

- pmid:30116051 + pmid:25681350 - a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) + composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - - - pmid:30116051 - - a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) - + @@ -19510,2080 +20925,2098 @@

Statements

- pmid:30444369 + pmid:21329555 - a(PUBCHEM:5757) decreases a(HBP:"amyloid-beta aggregates") + complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1) - pmid:30444369 + pmid:21329555 - a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(FPLX:NFkappaB), ma(tscript)) increases r(HGNC:BACE1) - pmid:30444369 + pmid:29179999 - a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) + act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response") - pmid:30444369 + pmid:29179999 - a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(Ph)) + tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response") - pmid:30444369 + pmid:27288790 - a(PUBCHEM:5757) increases p(HGNC:BCL2) + p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response") - pmid:30444369 + pmid:29179999 - a(PUBCHEM:5757) increases p(HGNC:BCL2L1) + p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pmid:27288790 - a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) + act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pmid:29179999 - a(PUBCHEM:5757) increases p(HGNC:SOD2) + act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration) - pmid:30444369 + pmid:29179999 - a(PUBCHEM:5757) increases p(FPLX:GPX) + act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase") - pmid:30444369 + pmid:29179999 - p(FPLX:GABR) association act(p(HGNC:HSD17B10)) + act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2) - pmid:17009926 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) + p(FPLX:NFkappaB) regulates p(HGNC:PTGS2) - pmid:17009926 + pmid:29179999 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) + act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) - pmid:11230871 + pmid:29179999 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) + act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD) - pmid:26837465 + pmid:29179999 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) + act(p(FPLX:NFkappaB)) increases p(HGNC:BACE1) + + - pmid:19277525 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") + p(FPLX:NFkappaB) association path(MESH:Inflammation) - pmid:22908190 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") + p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process") - pmid:29758300 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") - pmid:30145931 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) association bp(GO:"apoptotic process") - pmid:17403556 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth") - pmid:25374103 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity") - pmid:26631930 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(FPLX:NFkappaB)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:24401760 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) biomarkerFor path(MESH:"Alzheimer Disease") + act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB)) + + - pmid:29758300 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(FPLX:NFkappaB)) increases p(HGNC:IL1B) - pmid:25374103 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(FPLX:NFkappaB)) increases p(HGNC:TNF) - pmid:26631930 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1) - pmid:29758300 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2)) - pmid:21882945 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) - pmid:25374103 + pmid:27288790 - tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(HBP:"Tau aggregates") + act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines) - pmid:28877763 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(HBP:"Tau aggregates") + p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-1") - pmid:26631930 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-2") - pmid:29758300 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") + p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-146a") - pmid:30145931 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) + p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-155") - pmid:22611162 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") + act(p(FPLX:NFkappaB), ma(tscript)) increases m(MIRBASE:"hsa-mir-155") - pmid:26631930 + pmid:30640040 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") + p(FPLX:NFkappaB) association a(PUBCHEM:5318517) - pmid:22611162 + pmid:26118667 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") + p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) + + + + + + - pmid:22611162 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") + complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1) - pmid:25374103 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(HGNC:NFKBIA) decreases a(CHEBI:"amyloid-beta") + + + + - pmid:28877763 + pmid:29179999 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association act(p(HGNC:SYK)) + p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) - pmid:26458742 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:HBP00006) + p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) + + - pmid:26458742 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:26631930 + pmid:21329555 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin") + p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(tscript)) - pmid:26631930 + pmid:29179999 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(HBP:Neurodegeneration) + p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) - pmid:26631930 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(a(GO:synapse)) + p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:23487739 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule) + p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:19732809 + pmid:27288790 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) - - - pmid:30444369 + pmid:28745240 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:29758300 + pmid:21958873 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:21882945 + pmid:25331948 - act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:29191965 + pmid:28745240 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29311797 + pmid:27288790 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:12551948 + pmid:25652642 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24183963 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases path(HBP:neurotoxicity) - pmid:18494933 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases bp(GO:"neuron death") - pmid:29121589 + pmid:27288790 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(Ph)) - pmid:10998059 + pmid:27288790 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - pmid:27314526 + pmid:23178521 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - pmid:22122372 + pmid:23178521 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - pmid:22122372 + pmid:23178521 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - pmid:22122372 + pmid:27288790 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + p(HGNC:TNF) decreases p(FPLX:IKB) - pmid:24653673 + pmid:27288790 - p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") + p(HGNC:TNF) increases a(MESH:Cytokines) - pmid:24653673 + pmid:27288790 - act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") + p(HGNC:TNF) increases a(MESH:Chemokines) - pmid:24653673 + pmid:27288790 - act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + p(HGNC:TNF) increases act(p(HGNC:BACE1)) - pmid:24653673 + pmid:21958873 - act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + p(HGNC:TNF) increases p(HGNC:BACE1) - pmid:24653673 + pmid:25331948 - act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing") + p(HGNC:TNF) increases p(HGNC:BACE1) - pmid:24653673 + pmid:25331948 - act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) + p(HGNC:TNF) increases p(HGNC:BACE1) - pmid:24653673 + pmid:27288790 - act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + p(HGNC:TNF) increases act(p(FPLX:ERK)) - pmid:24653673 + pmid:27288790 - act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") + p(HGNC:TNF) increases p(HGNC:MAPT, pmod(Ph)) - pmid:24653673 + pmid:25652642 - act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:TNF) increases p(HGNC:NGF) - pmid:24653673 + pmid:25652642 - act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + p(HGNC:TNF) increases p(HGNC:BCL2) - pmid:24653673 + pmid:19126755 - act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:TNF) increases bp(GO:"MAPK cascade") - pmid:24653673 + pmid:19293145 - act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(HGNC:TNF) increases act(a(CHEBI:nicotine)) - pmid:24653673 + pmid:19293145 - act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) + p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) - pmid:24653673 + pmid:23178521 - act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) + p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph)) - pmid:24653673 + pmid:23178521 - act(p(HGNC:GSK3B)) increases p(HGNC:SET) + p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) - pmid:21882945 + pmid:23178521 - p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) + p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) - - pmid:25331948 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") - pmid:14612456 + pmid:21329555 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) - pmid:17078951 + pmid:21329555 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) - pmid:19459590 + pmid:21329555 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:29844403 + pmid:21329555 - act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1) - pmid:25331948 + pmid:27288790 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1)) - pmid:14612456 + pmid:19126755 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) - pmid:17078951 + pmid:19126755 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) - pmid:19459590 + pmid:21329555 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:25331948 + pmid:27288790 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:14612456 + pmid:21329555 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) - pmid:17078951 + pmid:27288790 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) - pmid:21734277 + pmid:27288790 - act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:ibuprofen) decreases a(CHEBI:"amyloid-beta") - - - - - pmid:30640040 + pmid:21329555 - p(HGNC:GSK3B) association a(PUBCHEM:71295844) + a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:29191965 + pmid:21329555 - p(HGNC:GSK3B) association path(MESH:Tauopathies) + a(PUBCHEM:3715) decreases r(HGNC:BACE1) - pmid:11812770 + pmid:28745240 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244")) + p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) - pmid:11812770 + pmid:26813123 - p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) + p(HGNC:SYP) association bp(GO:memory) + + + + + + - pmid:14612456 + pmid:28745240 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") - pmid:17078951 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") - pmid:21734277 + pmid:28745240 - act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:NFKB1) increases bp(GO:learning) - pmid:18494933 + pmid:28745240 - act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") + p(HGNC:NFKB1) increases path(MESH:Anxiety) - pmid:18494933 + pmid:27288790 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process") - pmid:12551948 + pmid:23702978 - p(HGNC:GSK3B) association p(HGNC:YWHAZ) + p(HGNC:NFKB1) increases p(HGNC:IL1B) - pmid:12551948 + pmid:28745240 - p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) - pmid:29121589 + pmid:26813123 - p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph)) + a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") - pmid:29121589 + pmid:25514383 - p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) + a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24355211 + pmid:22908190 - p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) + act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29121589 + pmid:22908190 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:DPYSL2, pmod(Ph)) + act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:7514173 + pmid:28445721 - act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph)) + act(a(GO:synapse)) regulates p(FPLX:CHRN) - pmid:7514173 + pmid:30106381 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph)) + act(a(GO:synapse)) association p(HGNC:ADNP) - pmid:7514173 + pmid:30106381 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph)) + act(a(GO:synapse)) association a(PUBCHEM:9832404) - pmid:7514173 + pmid:22908190 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph)) + act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) - pmid:7514173 + pmid:22908190 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph)) + act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") - pmid:17078951 + pmid:22908190 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) - pmid:17078951 + pmid:22908190 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) - pmid:19459590 + pmid:26631930 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) - pmid:21734277 + pmid:26631930 - act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) - pmid:17078951 + pmid:27807169 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217)) + a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2) - pmid:17078951 + pmid:22156579 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(GO:synapse) negativeCorrelation p(HGNC:MARK4) + + + + - pmid:17078951 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) - pmid:17078951 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) - pmid:9089387 + pmid:25652642 - act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) + act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") - pmid:9089387 + pmid:21214928 - p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26") + bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") - pmid:26501932 + pmid:26813123 - p(HGNC:GSK3B) partOf a(HBP:"GVD bodies") + bp(MESH:"Synaptic Transmission") association bp(GO:memory) - pmid:25331948 + pmid:14556719 - act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1") + bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) - pmid:25331948 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation act(p(HGNC:SYK)) + bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) - pmid:28176663 + pmid:28745240 - act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") + bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) - pmid:28176663 + pmid:19126755 - act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") + bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") - pmid:28176663 + pmid:24511233 - act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") + bp(GO:"long-term synaptic potentiation") association bp(GO:learning) - pmid:19459590 + pmid:24511233 - act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, AT8") + bp(GO:"long-term synaptic potentiation") association bp(GO:memory) - pmid:24355211 + pmid:21787755 - p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") + bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") - pmid:24355211 + pmid:22908190 - p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) + bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:24355211 + pmid:24760868 - p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT, loc(GO:synapse)) - pmid:24355211 + pmid:24760868 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) - pmid:24355211 + pmid:24760868 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) - pmid:25546293 + pmid:24760868 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins, loc(GO:synapse)) - pmid:25546293 + pmid:24760868 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) - pmid:25546293 + pmid:24760868 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN, loc(GO:synapse)) - pmid:30444369 + pmid:24760868 - a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1, loc(GO:synapse)) - pmid:30444369 + pmid:24760868 - a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction") + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) - pmid:30444369 + pmid:24760868 - a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4, loc(GO:synapse)) - pmid:30444369 + pmid:24760868 - a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates") + bp(GO:"long-term synaptic potentiation") association complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:29758300 + pmid:24760868 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) + bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:29758300 + pmid:24760868 - a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) + bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines")) - pmid:29758300 + pmid:21882945 - a(CHEBI:"methylene blue") increases p(HGNC:BECN1) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) - pmid:30116051 + pmid:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:BECN1) + p(HGNC:REL) increases bp(GO:"long-term synaptic depression") - pmid:29758300 + pmid:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) + bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) - pmid:29758300 + pmid:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) + bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) - pmid:30116051 + pmid:22908190 - a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) + bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:23528736 + pmid:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) + a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) - pmid:29758300 + pmid:25652642 - a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) + a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) - pmid:30116051 + pmid:25652642 - a(CHEBI:"methylene blue") decreases a(HBP:HBP00009) + a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) - pmid:30116051 + pmid:16273023 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + a(CHEBI:"glutamate(1-)") association path(MESH:D013850) - pmid:30116051 + pmid:16273023 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + a(CHEBI:"glutamate(1-)") association path(MESH:D008568) - pmid:23528736 + pmid:27087442 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25") - pmid:29626319 + pmid:28745240 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:30116051 + pmid:28745240 - a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:30116051 + pmid:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:30116051 + pmid:30444369 - a(CHEBI:"methylene blue") increases p(HGNC:DCTN4) + bp(GO:"neuron death") association p(HGNC:SH3GL2) - pmid:24027553 + pmid:29196815 - a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) + bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074) - pmid:22611162 + pmid:21214928 - a(CHEBI:"methylene blue") increases bp(GO:locomotion) + bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) - pmid:29191965 + pmid:22122372 - a(CHEBI:"methylene blue") positiveCorrelation bp(GO:locomotion) + bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") - pmid:22611162 + pmid:17009926 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pmid:17009926 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pmid:25514383 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pmid:28420982 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21882945 + pmid:26631930 - a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:21787755 - a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") + bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") - pmid:26751493 + pmid:29758300 - a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) + bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") - pmid:26751493 + pmid:14556719 - a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:23666762 + pmid:22908190 - a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) + bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) - pmid:23666762 + pmid:24027553 - a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) + bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) - pmid:28287136 + pmid:21882945 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) + bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) - pmid:24563850 + pmid:28420982 - a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") + bp(GO:"neuron death") association path(MESH:Tauopathies) - pmid:24563850 + pmid:28745240 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") + path(HBP:Excitotoxicity) increases bp(GO:"neuron death") - pmid:24563850 + pmid:28745240 - a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") - pmid:24563850 + pmid:28745240 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) - pmid:24563850 + pmid:21214928 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) - pmid:24563850 + pmid:21214928 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) - pmid:23702978 + pmid:21214928 - a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:22122372 - a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) - pmid:30444369 + pmid:22122372 - bp(GO:"neuron death") association p(HGNC:SH3GL2) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) - pmid:29196815 + pmid:22122372 - bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074) + a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) - pmid:21214928 + pmid:25514383 - bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22122372 + pmid:24653673 - bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:26751493 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") - pmid:17009926 + pmid:27796283 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) - pmid:25514383 + pmid:27796283 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) - pmid:28420982 + pmid:22833681 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") - pmid:26631930 + pmid:22833681 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1") - pmid:21787755 + pmid:22833681 - bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180") - pmid:29758300 + pmid:22833681 - bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100") - pmid:14556719 + pmid:28745240 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") + bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pmid:28745240 - bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) + bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) - pmid:24027553 + pmid:28745240 - bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) + bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) - pmid:21882945 + pmid:28745240 - bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) + bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) - pmid:28420982 + pmid:28745240 - bp(GO:"neuron death") association path(MESH:Tauopathies) + bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) - pmid:25437566 + pmid:26813123 - a(CHEBI:ATP) association act(p(FPLX:HSP90)) + bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) - pmid:23746257 + pmid:28745240 - a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) + act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) - pmid:25437566 + pmid:28745240 - a(CHEBI:ATP) association act(p(FPLX:HSPA)) + act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) - pmid:23746257 + pmid:28745240 - a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) + act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:25437566 + pmid:28745240 - a(CHEBI:ATP) association act(p(HGNC:HSPD1)) + act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) - pmid:23746257 + pmid:22122372 - a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) + p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:23746257 + pmid:22122372 - a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) + p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) - pmid:23746257 + pmid:22122372 - a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:24457024 + pmid:26631930 - a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:24457024 + pmid:26631930 - a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:27671637 + pmid:28745240 - a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:24561250 + pmid:28745240 - a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:24561250 + pmid:28745240 - a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:24561250 + pmid:25652642 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:24561250 + pmid:28745240 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:24561250 + pmid:28745240 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) - pmid:24561250 + pmid:18650430 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(FPLX:PKC) increases sec(p(HGNC:APP)) - pmid:29758300 + pmid:24590577 - p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) + act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) - pmid:30116051 + pmid:26813123 - act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) + p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph)) - pmid:24027553 + pmid:26813123 - act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) + p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph)) - pmid:24027553 + pmid:24590577 - act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) + act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) - pmid:29238289 + pmid:24590577 - act(p(HGNC:CASP3)) increases p(HGNC:MAPT) + act(p(FPLX:PKC)) increases p(HGNC:BACE1) - pmid:24027553 + pmid:24590577 - act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") + act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) - pmid:24027553 + pmid:17493042 - act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") + p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) - pmid:25374103 + pmid:28745240 - act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau C3") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:24027553 + pmid:28745240 - act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) - pmid:25374103 + pmid:28745240 - act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) - - - pmid:26631930 + pmid:28745240 - p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) + act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) - pmid:26631930 + pmid:28745240 - p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) + act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:27068745 + pmid:28745240 - p(HGNC:CASP3) association act(p(FPLX:JNK)) + act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) - pmid:27068745 + pmid:27288790 - p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) + act(p(FPLX:AKT)) increases p(HGNC:RELA) + + - pmid:27068745 + pmid:19293145 - p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") + act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") - pmid:27314526 + pmid:23454242 - act(p(HGNC:CASP3)) increases bp(GO:"neuron death") + p(FPLX:AKT) regulates bp(GO:"apoptotic process") @@ -21592,188 +23025,184 @@

Statements

pmid:19293145 - bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") - pmid:24653673 + pmid:25514383 - bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) + act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) - pmid:24653673 + DOI:10.4172/2168-975X.1000126 - bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) + p(FPLX:AKT) directlyIncreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:24653673 + pmid:25331948 - bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) + p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:24027553 + pmid:29121589 - bp(GO:"apoptotic process") association p(HGNC:MAPT, frag("?", "17kD")) + p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + + - pmid:24027553 + pmid:23454242 - bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) + p(FPLX:AKT) regulates bp(GO:"cell growth") - pmid:26304819 + pmid:23454242 - bp(GO:"apoptotic process") association r(HGNC:GAPDH) + p(FPLX:AKT) regulates bp(GO:"cell population proliferation") + + - pmid:23948915 + pmid:29121589 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) - pmid:23948915 + pmid:28745240 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:23948915 + pmid:28745240 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex")) - - - pmid:30444369 + pmid:24511233 - p(HGNC:BCL2) decreases bp(GO:"apoptotic process") + bp(GO:behavior) association path(MESH:Schizophrenia) - - - pmid:23528736 + pmid:24511233 - p(HGNC:BCL2) decreases bp(GO:autophagy) + bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") - pmid:30444369 + pmid:28420982 - p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") + bp(GO:behavior) association p(HGNC:MAPT) - pmid:30444369 + pmid:17009926 - p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") + path(MESH:Anxiety) association p(FPLX:CHRN) - - - pmid:23528736 + pmid:11230871 - p(HGNC:BCL2L11) decreases bp(GO:autophagy) + path(MESH:Anxiety) association p(FPLX:CHRN) - pmid:24563850 + pmid:21482353 - p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") - pmid:30444369 + pmid:28901280 - act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") - pmid:30444369 + pmid:28775333 - p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) - - - pmid:30444369 + pmid:28745240 - p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) - pmid:24653673 + pmid:21214928 - p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") + p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") @@ -21782,403 +23211,405 @@

Statements

pmid:8282104 - p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKACA) association a(GO:microtubule) - pmid:30444369 + pmid:8282104 - p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(Ph, Thr, 89)) + p(HGNC:PRKACA) association a(HBP:HBP00006) - pmid:22122372 + pmid:28745240 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") + + - pmid:22122372 + pmid:28745240 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pmid:21214928 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + bp(GO:"calcium ion homeostasis") association p(HGNC:APP) - pmid:24653673 + pmid:19293145 - act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") + bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:24653673 + pmid:29758300 - act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) - pmid:24653673 + pmid:28745240 - act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta") - pmid:24653673 + pmid:28745240 - act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing") + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - pmid:24653673 + pmid:28745240 - act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - pmid:24653673 + pmid:28745240 - act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - pmid:24653673 + pmid:28745240 - act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") + bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") - pmid:29758300 + pmid:25652642 - p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") - pmid:8282104 + pmid:27623715 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") - pmid:21882945 + pmid:22020111 - act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") - pmid:29191965 + pmid:22020111 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pmid:26195256 - p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Oxidative Stress") increases path(MESH:Aging) - pmid:8282104 + pmid:21131359 - p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph)) + bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:8282104 + pmid:27623715 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) - pmid:17078951 + pmid:27623715 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") - pmid:8282104 + pmid:27623715 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) - pmid:8282104 + pmid:27623715 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") - pmid:8282104 + pmid:27623715 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") - pmid:8282104 + pmid:23722080 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) - pmid:8282104 + pmid:24355211 - p(HGNC:CDK5) association a(GO:microtubule) + bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) - pmid:8282104 + pmid:8226987 - p(HGNC:CDK5) association a(HBP:HBP00006) + bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:8282104 + pmid:7667312 - p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments") - pmid:21882945 + pmid:28745240 - p(HGNC:CDK5) increases act(p(HGNC:MARK2)) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) - pmid:21367866 + pmid:27288790 - act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37) + bp(GO:"apoptotic process") association p(FPLX:NFkappaB) - pmid:27796283 + pmid:19293145 - p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345)) + bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:17078951 + pmid:24653673 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) - pmid:17078951 + pmid:24653673 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) - pmid:17078951 + pmid:24653673 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) - pmid:17078951 + pmid:24027553 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + bp(GO:"apoptotic process") association p(HGNC:MAPT, frag("?", "17kD")) - pmid:17078951 + pmid:24027553 - act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) + bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) - pmid:17078951 + pmid:26304819 - act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) + bp(GO:"apoptotic process") association r(HGNC:GAPDH) - pmid:17078951 + pmid:23948915 - act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:17078951 + pmid:23948915 - act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:17078951 + pmid:23948915 - act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:8702879 + pmid:28745240 - act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) + bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") - pmid:8702879 + pmid:28745240 - act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) + bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) - pmid:26118667 + pmid:28745240 - p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) + bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") - pmid:25001178 + pmid:28745240 - act(p(HGNC:CDK5), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:25001178 + pmid:28745240 - act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin)) + p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918)) - pmid:30444369 + pmid:28745240 - p(HGNC:PRDX2, pmod(Ph, Thr, 89)) decreases act(p(HGNC:PRDX2)) + p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") @@ -22187,25 +23618,25 @@

Statements

pmid:30444369 - p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") + p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") - pmid:30444369 + pmid:25652642 - p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta")) - pmid:30444369 + pmid:28745240 - p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) + p(HGNC:BCL2) decreases bp(GO:"apoptotic process") @@ -22214,1807 +23645,1809 @@

Statements

pmid:30444369 - p(HGNC:SH3GL2) association bp(GO:"neuron projection development") + p(HGNC:BCL2) decreases bp(GO:"apoptotic process") + + - pmid:30444369 + pmid:23528736 - p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") + p(HGNC:BCL2) decreases bp(GO:autophagy) - pmid:30444369 + pmid:28745240 - p(HGNC:SH3GL2) association bp(GO:"neuron death") + p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") - pmid:30444369 + pmid:28745240 - bp(GO:"neuron projection development") association p(HGNC:SH3GL2) + a(CHEBI:etoposide) increases bp(GO:"apoptotic process") - pmid:20133804 + pmid:29196815 - bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) + a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pmid:22122372 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) + a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:18650430 - bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) + a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") - pmid:17009926 + pmid:22122372 - bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) + a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018) - pmid:24590577 + pmid:11230871 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) + a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) - pmid:22908190 + pmid:14556719 - bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") - pmid:22908190 + pmid:28745240 - bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) + p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") - pmid:22908190 + pmid:28745240 - bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) + p(HGNC:SOD2) decreases bp(GO:"apoptotic process") - pmid:26631930 + pmid:25652642 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) + act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta")) - pmid:30444369 + pmid:24563850 - a(HBP:AG18051) decreases act(p(HGNC:HSD17B10)) + p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) - - - pmid:30444369 - - a(HBP:AG18051) decreases act(a(HBP:"amyloid-beta aggregates")) - + + + + + + + + + + + + + - pmid:30444369 + pmid:28745240 - a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10)) + a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(HBP:nitration)) - pmid:30444369 + pmid:16566606 - a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration)) - pmid:30444369 + pmid:21210655 - a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) - pmid:30444369 + pmid:16816118 - p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(Ph)) - pmid:30444369 + pmid:16816118 - p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) + a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration)) - pmid:30444369 + pmid:16816118 - p(HGNC:CSNK1A1) association a(HBP:"amyloid-beta aggregates") + a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) - pmid:25974414 + pmid:16816118 - act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) - pmid:25673844 + pmid:16816118 - p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) - pmid:25546293 + pmid:16816118 - p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 35)) + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) - pmid:30444369 + pmid:16816118 - a(PUBCHEM:208907) decreases act(p(HGNC:MAOA)) + a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) - pmid:30444369 + pmid:16816118 - a(PUBCHEM:208907) causesNoChange act(p(HGNC:CSNK1A1)) + a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) - pmid:22040696 + pmid:16816118 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) + a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) - pmid:29758300 + pmid:16816118 - path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(HBP:"protein aggregates") + a(CHEBI:peroxynitrite) increases bp(GO:"neurofibrillary tangle assembly") - pmid:29758300 + pmid:16566606 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - pmid:22908190 + pmid:16566606 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:25784053 + pmid:16566606 - path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) - pmid:18930136 + pmid:16566606 - path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(HBP:misfolding)) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) - pmid:18930136 + pmid:27314526 - path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) + a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") - pmid:18930136 + pmid:27314526 - path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) + a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") + + + + - pmid:29024336 + pmid:28745240 - path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") + composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) - pmid:29024336 + pmid:28745240 - path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") + composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) - pmid:24027553 + pmid:19293145 - path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) + bp(MESH:Neuroprotection) association p(HGNC:FYN) - pmid:23528736 + pmid:19293145 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) + bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") - pmid:23528736 + pmid:19293145 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) + bp(MESH:Neuroprotection) association a(MESH:Calcineurin) - pmid:23528736 + pmid:19293145 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) + bp(MESH:Neuroprotection) association p(HGNC:JAK2) - pmid:23528736 + pmid:19721446 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) + bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) - pmid:23528736 + pmid:19721446 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) + bp(MESH:Neuroprotection) association a(CHEBI:nicotine) + + + + - pmid:29191965 + pmid:28745240 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") + composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) - pmid:29311797 + pmid:28745240 - path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) + composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) - pmid:29196815 + pmid:24653673 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) - pmid:19126755 + pmid:24653673 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) - pmid:19293145 + pmid:24653673 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) - pmid:19293145 + pmid:26631930 - path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) association p(HGNC:MAPT) - pmid:19293145 + pmid:28745240 - path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") + p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) - pmid:24511233 + pmid:28745240 - path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) - pmid:24590577 + pmid:28745240 - path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") + p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) - pmid:25514383 + pmid:26304819 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:22817713 + pmid:28745240 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) - pmid:19293145 + pmid:28745240 - path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) + path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) - pmid:19293145 + pmid:28745240 - path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) + path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) - pmid:19293145 + pmid:28745240 - path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) + path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) - pmid:24511233 + pmid:30126037 - path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") + path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) - pmid:24511233 + pmid:29626319 - path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation) + path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) - pmid:24511233 + pmid:26195256 - path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") + path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates") - pmid:24590577 + pmid:29626319 - path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) - pmid:25514383 + pmid:29626319 - path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) + path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) - pmid:29758300 + pmid:29626319 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Parkinson Disease") + path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) - pmid:14556719 + pmid:29626319 - path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") + path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") - pmid:24027553 + pmid:29626319 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAP1LC3A) + path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") - pmid:28420982 + pmid:24561250 - path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) + path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") - pmid:23531502 + pmid:28745240 - path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein)) + a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) - pmid:18562203 + pmid:28745240 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) - pmid:26400044 + pmid:29179999 - path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC)) - pmid:18239272 + pmid:29179999 - path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8") + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK)) - pmid:28877763 + pmid:29179999 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(MGI:Syk, pmod(Ph)) + a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:28877763 + pmid:27288790 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB)) - pmid:24401760 + pmid:27288790 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) + a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB)) - pmid:24401760 + pmid:27288790 - path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite") + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex")) - pmid:29196815 + pmid:27288790 - a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22122372 + pmid:27288790 - a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity") - pmid:18650430 + pmid:27288790 - a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") + a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport") - pmid:22122372 + pmid:27288790 - a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018) + a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:11230871 + pmid:27288790 - a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) + a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy) - pmid:14556719 + pmid:24563850 - a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") + a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) - pmid:29196815 + pmid:27288790 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(Ph)) - pmid:28420982 + pmid:24563850 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") - pmid:22817713 + pmid:24563850 - a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") - pmid:24653673 + pmid:24563850 - a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(Me, Tyr, 307)) + a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") - pmid:29758300 + pmid:24563850 - a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) + a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") - pmid:22908190 + pmid:24563850 - a(GO:"neurofibrillary tangle") association a(HBP:"paired helical filaments") + a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") - pmid:22908190 + pmid:23702978 - a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) + a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) - pmid:22908190 + pmid:23702978 - a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) + a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") - pmid:22908190 + pmid:28745240 - a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) + path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pmid:28745240 - a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") + path(MESH:Hypoxia) increases bp(GO:neurogenesis) - pmid:22908190 + pmid:28745240 - a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) - pmid:18930136 + pmid:28745240 - a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) + a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) - pmid:27671637 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) + a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) - pmid:30126037 + pmid:29559585 - a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") + a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO)) - pmid:30126037 + pmid:27601475 - a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") + a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP") - pmid:30126037 + pmid:23702978 - a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) + a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO)) - pmid:30126037 + pmid:27314526 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) + a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) - pmid:30126037 + pmid:27314526 - a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) + a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) - pmid:30126037 + pmid:27314526 - a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) + a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) - pmid:30126037 + pmid:27314526 - a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") + a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") + path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") + path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") + a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:24511233 - a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") + a(MESH:"Cerebral Cortex") association bp(GO:cognition) - pmid:30126037 + pmid:24511233 - a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) + a(MESH:"Cerebral Cortex") association bp(GO:learning) - pmid:30126037 + pmid:24511233 - a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) + a(MESH:"Cerebral Cortex") association bp(GO:learning) - pmid:30126037 + pmid:24511233 - a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) + a(MESH:"Cerebral Cortex") association bp(GO:memory) - pmid:30126037 + pmid:24511233 - a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) + a(MESH:"Cerebral Cortex") association bp(GO:memory) - pmid:30126037 + pmid:24590577 - a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) + a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) - pmid:30126037 + pmid:26195256 - a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) + a(MESH:"Cerebral Cortex") association path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) + p(HGNC:IL6) increases bp(GO:"astrocyte development") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) + p(HGNC:IL6) increases p(HGNC:STAT3) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) + p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) + p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) + p(HGNC:IL6) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:25652642 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) + p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) + p(HGNC:IL6) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) + p(HGNC:IL6) increases bp(GO:"neuron death") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) + a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) + p(HGNC:LIF) increases bp(GO:"astrocyte development") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") + p(HGNC:LIF) increases p(HGNC:STAT3) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") + p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") + p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) - pmid:30126037 + pmid:28745240 - a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") + p(HGNC:CNTF) increases bp(GO:"astrocyte development") - pmid:26751493 + pmid:28745240 - a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) + p(HGNC:CNTF) increases p(HGNC:STAT3) - pmid:26751493 + pmid:28745240 - a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) + p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") - pmid:26751493 + pmid:28745240 - a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) + p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) - pmid:23531502 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein)) + p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) - pmid:12578227 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) + p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") - pmid:12578227 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) + p(HGNC:CNTF) increases act(p(HGNC:LCK)) - pmid:9099822 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2)) + bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(Ph, Ser, 536)) - pmid:11089576 + pmid:27288790 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB) - pmid:11738469 + pmid:21214928 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) - pmid:8985134 + pmid:23383175 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + act(a(GO:axon)) decreases path(MESH:Paralysis) - pmid:18239272 + pmid:23383175 - a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8") + act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") - pmid:26751493 + pmid:28745240 - a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") + p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") - pmid:26118667 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25") + p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:22002427 + pmid:28745240 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:BDNF) increases act(p(HGNC:SRC)) - pmid:22002427 + pmid:22040696 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) + p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") - pmid:29196815 + pmid:22040696 - path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) regulates bp(GO:"central nervous system development") - pmid:21482353 + pmid:22040696 - path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") + p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") - pmid:29196815 + pmid:22040696 - path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") - pmid:29196815 + pmid:22040696 - path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") - pmid:26195256 + pmid:22040696 - path(MESH:"Diabetes Mellitus") association path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") - pmid:29626319 + pmid:22040696 - path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) + p(HGNC:BDNF) association p(HGNC:CHRNA7) - pmid:29626319 + pmid:22040696 - path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:BDNF) increases p(HGNC:CHRNA7) - pmid:29196815 + pmid:22040696 - g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) - pmid:26837465 + pmid:28632203 - complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) + p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:26837465 + pmid:28745240 - complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) + act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) - pmid:24368848 + pmid:19293145 - complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) + p(HGNC:SRC) increases bp(MESH:Neuroprotection) - pmid:23407988 + pmid:24653673 - complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") + p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) - pmid:10391244 + pmid:24653673 - complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) - pmid:10391244 + pmid:24653673 - complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) + p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) - pmid:12714745 + pmid:24653673 - complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) + p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) - pmid:29196815 + pmid:29191965 - a(HBP:HBP00074) increases bp(GO:"neuron death") + p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - pmid:29196815 + pmid:26751493 - a(HBP:HBP00074) increases bp(GO:"neuron death") + p(HGNC:SRC) association p(HBP:"projection domain") - - - pmid:29196815 - - a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death") - - - pmid:21718217 + pmid:18467332 - a(HBP:HBP00074) increases bp(GO:"neuron death") + p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) - pmid:29196815 + pmid:26751493 - a(HBP:HBP00074) decreases a(MESH:Synapses) + p(HGNC:SRC) association a(HBP:"projection domain") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases a(MESH:Synapses) + p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases a(MESH:Synapses) + act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) - pmid:29196815 + pmid:30640040 - a(HBP:HBP00074) decreases bp(GO:memory) + p(HGNC:LCK) association a(PUBCHEM:4878) - pmid:29196815 + pmid:29191965 - a(HBP:HBP00074) decreases bp(GO:memory) + p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - pmid:29196815 + pmid:26751493 - a(HBP:HBP00074) decreases bp(GO:memory) + p(HGNC:LCK) association p(HBP:"projection domain") - pmid:29196815 + pmid:26631930 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:29196815 + pmid:26751493 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:LCK) association a(HBP:"projection domain") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") + p(HGNC:RELA, pmod(Ph, Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases path(MESH:Dementia) + bp(GO:"axon guidance") increases bp(GO:neurogenesis) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") + bp(GO:"axon guidance") increases a(GO:axon) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:ITGB1) increases bp(GO:"axon guidance") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases bp(GO:"signal release from synapse") + p(HGNC:ITGB1) increases a(GO:axon) - pmid:29196815 + pmid:21214928 - a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") + p(HGNC:ITGB1) association p(HGNC:APP) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph)) + p(HGNC:NCAM1) increases a(GO:axon) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") + p(HGNC:SLITRK1) increases a(GO:axon) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases bp(GO:"microglial cell activation") + p(HGNC:GFRA1) increases a(GO:axon) - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases bp(GO:"astrocyte activation") + p(HGNC:TIAM1) increases a(GO:axon) + + - pmid:29196815 + pmid:22020111 - a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation") + act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") + p(HGNC:HES1) increases a(GO:"dendritic branch") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases act(p(HGNC:GRIN1)) + p(HGNC:HES1) increases a(MESH:"Dendritic Cells") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:HES5) increases a(GO:"dendritic branch") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:HES5) increases a(MESH:"Dendritic Cells") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) increases act(p(HGNC:NGFR)) + p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) decreases p(HGNC:INSR) + p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") - - - pmid:29196815 - - a(HBP:HBP00074) negativeCorrelation a(CTO:"Mini_Mental_State_Examination") - + - - - pmid:29196815 - - a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") - + - pmid:29196815 + pmid:28745240 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") + complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) - pmid:21718217 + pmid:28745240 - a(HBP:HBP00074) decreases bp(GO:"synaptic signaling") + p(HGNC:IL1B) increases bp(GO:"neuron death") - pmid:19293145 + pmid:27288790 - a(MESH:Synapses) increases bp(GO:cognition) + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29196815 + pmid:25652642 - a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29196815 + pmid:24561250 - a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:27314526 - path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:27288790 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:24511233 + pmid:27288790 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:25514383 + pmid:27288790 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(Ph)) - pmid:26813123 + pmid:27288790 - path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") + p(HGNC:IL1B) increases p(HGNC:RELA, pmod(Ph)) - pmid:25514383 + pmid:27288790 - path(MESH:Dementia) association bp(GO:aging) + p(HGNC:IL1B) decreases p(FPLX:IKB) - pmid:29758300 + pmid:27288790 - path(MESH:Dementia) association path(MESH:Tauopathies) + p(HGNC:IL1B) increases a(MESH:Cytokines) - pmid:22908190 + pmid:27288790 - path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") + p(HGNC:IL1B) increases a(MESH:Chemokines) - pmid:22908190 + pmid:23702978 - path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") + act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") - pmid:22908190 + pmid:24561250 - path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) + p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") - pmid:26631930 + pmid:24561250 - path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT) + p(HGNC:IL1B) increases bp(GO:"inflammatory response") @@ -24023,7 +25456,7 @@

Statements

pmid:27314526 - path(MESH:Dementia) association sec(a(MESH:Interleukins)) + p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) @@ -24032,7 +25465,7 @@

Statements

pmid:27314526 - path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) + p(HGNC:IL1B) increases bp(GO:"microglial cell activation") @@ -24041,169 +25474,173 @@

Statements

pmid:27314526 - path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) + p(HGNC:IL1B) increases bp(GO:"astrocyte activation") - pmid:19126755 + pmid:27314526 - bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") + sec(p(HGNC:IL1B)) increases p(HGNC:APP) - pmid:24511233 + pmid:27314526 - bp(GO:"long-term synaptic potentiation") association bp(GO:learning) + sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:28745240 - bp(GO:"long-term synaptic potentiation") association bp(GO:memory) + bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:21787755 + pmid:25514383 - bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") + bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") - pmid:22908190 + pmid:27314526 - bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) + bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") - pmid:24760868 + pmid:28784767 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT, loc(GO:synapse)) + p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn") - pmid:24760868 + pmid:21882945 - bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) + p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:24760868 + pmid:26118667 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) + complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) + + - pmid:24760868 + pmid:28745240 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins, loc(GO:synapse)) + act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:24760868 + pmid:30444369 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) + p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24760868 + pmid:24653673 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN, loc(GO:synapse)) + p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") - pmid:24760868 + pmid:8282104 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1, loc(GO:synapse)) + p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24760868 + pmid:30444369 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) + p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(Ph, Thr, 89)) - pmid:24760868 + pmid:22122372 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4, loc(GO:synapse)) + p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:24760868 + pmid:22122372 - bp(GO:"long-term synaptic potentiation") association complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) - pmid:24760868 + pmid:22122372 - bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:24760868 + pmid:24653673 - bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines")) + act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") - pmid:21882945 + pmid:24653673 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) + act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") @@ -24212,7 +25649,7 @@

Statements

pmid:24653673 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B)) + act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph)) @@ -24221,7 +25658,7 @@

Statements

pmid:24653673 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5)) + act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing") @@ -24230,7 +25667,7 @@

Statements

pmid:24653673 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK)) + act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) @@ -24239,7 +25676,7 @@

Statements

pmid:24653673 - p(HGNC:APP, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) + act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") @@ -24248,52 +25685,52 @@

Statements

pmid:24653673 - p(HGNC:APP, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) + act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") - pmid:21718217 + pmid:12428809 - bp(GO:"microglial cell activation") association a(HBP:HBP00089) + p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) - pmid:21718217 + pmid:29758300 - bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) + p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) - pmid:28877763 + pmid:8282104 - bp(GO:"microglial cell activation") positiveCorrelation act(p(HGNC:SYK)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:27314526 + pmid:21882945 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) + act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:27314526 + pmid:29191965 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) @@ -24302,566 +25739,554 @@

Statements

pmid:27314526 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) + p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) - pmid:27314526 + pmid:8282104 - bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) + p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph)) - pmid:29196815 + pmid:8282104 - bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:27671637 + pmid:17078951 - bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:27314526 + pmid:8282104 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:27314526 + pmid:8282104 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:27314526 + pmid:8282104 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:27314526 + pmid:8282104 - bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:29196815 + pmid:8282104 - act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) + p(HGNC:CDK5) association a(GO:microtubule) - pmid:29196815 + pmid:8282104 - act(p(HGNC:GRIN1)) increases bp(HBP:HBP00068) + p(HGNC:CDK5) association a(HBP:HBP00006) - pmid:29196815 + pmid:8282104 - act(p(HGNC:GRIN1)) increases bp(HBP:HBP00037) + p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) - pmid:29196815 + pmid:21882945 - act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) + p(HGNC:CDK5) increases act(p(HGNC:MARK2)) - pmid:24760868 + pmid:21367866 - p(HGNC:GRIA1, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37) - pmid:24760868 + pmid:27796283 - p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345)) - pmid:29196815 + pmid:17078951 - a(HBP:HBP00075) decreases p(MGI:Adrb2) + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:29196815 + pmid:17078951 - a(HBP:HBP00075) increases bp(GO:"microglial cell activation") + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:29196815 + pmid:17078951 - a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation") + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - - - - - pmid:29196815 + pmid:17078951 - complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:29196815 + pmid:17078951 - p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") + act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) - pmid:14556719 + pmid:17078951 - p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) + act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) - - - pmid:14556719 + pmid:17078951 - tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) + act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) - pmid:28420982 + pmid:17078951 - p(HGNC:PRNP) association a(HBP:"Tau oligomers") + act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) - pmid:29196815 + pmid:17078951 - a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") + act(p(HGNC:CDK5)) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) - pmid:29196815 + pmid:8702879 - a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) + act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) - pmid:29196815 + pmid:8702879 - a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") + act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) - - - - - pmid:29196815 + pmid:26118667 - p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) - pmid:29196815 + pmid:25001178 - p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") + act(p(HGNC:CDK5), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:18986241 + pmid:25001178 - p(HGNC:NGFR) association bp(GO:"GO:1901214") + act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin)) - pmid:18986241 + pmid:21548880 - p(HGNC:NGFR) increases act(p(HGNC:BACE1)) + p(HGNC:CDK5R1) increases act(p(HGNC:CDK5)) - pmid:18986241 + pmid:26118667 - p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta") + p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) - pmid:18986241 + pmid:26118667 - act(p(HGNC:NGFR)) association bp(GO:"GO:0006665") + p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25") + + - pmid:18986241 + pmid:19126755 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254") + path(HBP:neurotoxicity) association a(CHEBI:nicotine) - pmid:18986241 + pmid:19293145 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061") + path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers") - pmid:18986241 + pmid:19293145 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") + path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18986241 + pmid:22908190 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165") + path(HBP:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22142809 + pmid:24027553 - p(HGNC:NGFR) association p(HBP:RAC1b) + path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates") - pmid:29196815 + pmid:25652642 - a(CTO:"Mini_Mental_State_Examination") negativeCorrelation a(HBP:HBP00074) + bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:29196815 + pmid:24653673 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) + bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:29196815 + pmid:24653673 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) + bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) - pmid:29196815 + pmid:24653673 - path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) + bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK)) - pmid:19293145 + pmid:24027553 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers") + bp(HBP:"APP processing") association p(HGNC:HTRA1) - pmid:19293145 + pmid:24027553 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") + bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease") + + - pmid:24511233 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") + complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) - - - pmid:24511233 - - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - + - - - pmid:26813123 - - path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") - + - pmid:24511233 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) + complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) + + - pmid:26813123 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) + complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) - pmid:26813123 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) + complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) - - - pmid:27522251 - - path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") - + - - - pmid:21482353 - - path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) - + - pmid:11230871 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) + complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) + + + + + + - pmid:24027553 + pmid:28745240 - path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) + complex(GO:"gamma-secretase complex") regulates p(HBP:C99) - pmid:30108137 + pmid:29758300 - path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) + complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) - pmid:30126037 + pmid:14556719 - path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) + complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) - pmid:30126037 + pmid:14556719 - path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") + act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) - pmid:19765634 + pmid:14556719 - path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) + act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) - pmid:19765634 + pmid:21214928 - path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) + p(HGNC:PSEN1) regulates p(HGNC:APP) + + - pmid:29196815 + pmid:19293145 - a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration) - pmid:29196815 + pmid:19293145 - a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") - pmid:18650430 + pmid:29758300 - p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") - pmid:14556719 + pmid:29758300 - p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") + + + + pmid:22908190 - p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) increases bp(GO:"pH reduction") @@ -24870,770 +26295,740 @@

Statements

pmid:22908190 - p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) - pmid:18650430 + pmid:22908190 - p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") + p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(NGlyco)) - pmid:14556719 + pmid:24027553 - p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates") + p(HGNC:PSEN1) association path(MESH:"Alzheimer disease, familial, type 3") - pmid:22908190 + pmid:24027553 - p(HGNC:APP, var("?")) increases bp(GO:endocytosis) + p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") + + - pmid:22908190 + pmid:28745240 - p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) + act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:28420982 + pmid:28745240 - path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") + p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) - pmid:18650430 + pmid:28745240 - act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:SIRT1) decreases path(HBP:neurotoxicity) - pmid:21214928 + pmid:22020111 - p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac)) - pmid:22122372 + pmid:30116051 - p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:SIRT1) increases bp(GO:macroautophagy) - pmid:22122372 + pmid:30116051 - p(HGNC:ADAM17) increases a(HBP:HBP00067) + act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) - - - - - - - pmid:18650430 + pmid:30116051 - act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) - pmid:22122372 + pmid:30116051 - p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) - pmid:22122372 + pmid:30116051 - p(HGNC:ADAM9) increases a(HBP:HBP00067) + act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) - pmid:18650430 + pmid:30116051 - act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) - pmid:21214928 + pmid:30116051 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) - pmid:21214928 + pmid:26631930 - p(HGNC:ADAM10) increases p(HBP:HBP00067) + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys)) - pmid:21214928 + pmid:20869593 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) - pmid:21214928 + pmid:20869593 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8") - pmid:22122372 + pmid:29540553 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) - pmid:21214928 + pmid:29540553 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading") - pmid:21214928 + pmid:29540553 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + act(p(HGNC:SIRT1)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22122372 + pmid:29540553 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:SIRT1) positiveCorrelation bp(GO:learning) - pmid:22122372 + pmid:29540553 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:SIRT1) positiveCorrelation bp(GO:memory) - pmid:21214928 + pmid:29226865 - p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52)) - pmid:21214928 + pmid:28745240 - act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pmid:19293145 - p(HGNC:ADAM10) increases sec(p(HGNC:APP)) + a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) - pmid:24590577 + pmid:19293145 - p(HGNC:ADAM10) increases deg(p(HGNC:APP)) + a(MESH:Calcineurin) association bp(MESH:Neuroprotection) - pmid:22122372 + pmid:28745240 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072))) + p(HGNC:CXCL8) increases bp(GO:"neuron death") + + - pmid:22122372 + pmid:27288790 - p(HGNC:ADAM10) increases a(HBP:HBP00067) + p(FPLX:ERK) increases act(p(FPLX:NFkappaB)) - pmid:22122372 + pmid:19293145 - p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") + p(FPLX:ERK) association a(CHEBI:nicotine) - pmid:24590577 + pmid:24653673 - p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha") + act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") - pmid:18650430 + pmid:24653673 - act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") - pmid:21214928 + pmid:24653673 - p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph)) - pmid:21214928 + pmid:24653673 - p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing") - - - - - - - - - - - - - - - - - - - pmid:18650430 + pmid:24653673 - complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") + act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) - pmid:18650430 + pmid:24653673 - complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) + act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") - pmid:22122372 + pmid:24653673 - complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) + act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") - pmid:21214928 + pmid:12428809 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(FPLX:ERK) increases p(HGNC:MAPT, pmod(Ph)) - pmid:22122372 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072))) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?")) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) + p(FPLX:ERK) association a(GO:microtubule) - pmid:21214928 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) + p(FPLX:ERK) association a(HBP:HBP00006) - pmid:22122372 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) + p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) - pmid:22122372 + pmid:8282104 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) + p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22122372 + pmid:27594586 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) + p(FPLX:ERK) regulates p(HGNC:MMP9) - pmid:22122372 + pmid:24686445 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) + act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B)) - pmid:22122372 + pmid:29179999 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) + path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB)) - pmid:24590577 + pmid:27491084 - complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99)) + path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) - pmid:24590577 + pmid:27491084 - complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") + path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) - pmid:29626319 + pmid:27491084 - complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") + path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) - pmid:24590577 + pmid:24563850 - complex(FPLX:"Gamma_secretase") increases a(HBP:AICD) + act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) - pmid:21214928 + pmid:24563850 - p(HGNC:PSEN1) regulates p(HGNC:APP) + act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") - - - pmid:19293145 + pmid:24563850 - p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration) + act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive nitrogen species") - pmid:19293145 + pmid:27288790 - p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") + p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pmid:27288790 - p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") + p(HGNC:PTGS2) association a(HBP:"amyloid-beta aggregates") - pmid:29758300 + pmid:27288790 - p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") + p(HGNC:PTGS2) increases path(MESH:Inflammation) - - - - - pmid:22908190 + pmid:19126755 - p(HGNC:PSEN1) increases bp(GO:"pH reduction") + act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") - pmid:22908190 + pmid:19126755 - p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) + p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") - pmid:22908190 + pmid:19126755 - p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(NGlyco)) + p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") - pmid:24027553 + pmid:19126755 - p(HGNC:PSEN1) association path(MESH:"Alzheimer disease, familial, type 3") + p(HGNC:PTGS2) association p(HGNC:CHRNA4) - pmid:24027553 + pmid:27314526 - p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") + sec(a(MESH:Interleukins)) association path(MESH:Dementia) - - - - - pmid:21718217 + pmid:27314526 - p(HGNC:APH1A) decreases p(HGNC:APP) + sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) - pmid:21718217 + pmid:29179999 - p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:curcumin) decreases bp(GO:"inflammatory response") - pmid:18650430 + pmid:29179999 - p(FPLX:PKC) increases sec(p(HGNC:APP)) + a(CHEBI:curcumin) decreases p(HGNC:PTGS2) - pmid:24590577 + pmid:29179999 - act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) + a(CHEBI:curcumin) decreases p(HGNC:LOX) - pmid:26813123 + pmid:29179999 - p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph)) + a(CHEBI:curcumin) decreases p(HGNC:NOS2) - pmid:26813123 + pmid:29179999 - p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph)) + a(CHEBI:curcumin) decreases p(HGNC:TNF) - pmid:24590577 + pmid:29179999 - act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) + a(CHEBI:curcumin) decreases p(HGNC:IL1A) - pmid:24590577 + pmid:29179999 - act(p(FPLX:PKC)) increases p(HGNC:BACE1) + a(CHEBI:curcumin) decreases p(HGNC:IL2) - pmid:24590577 + pmid:29179999 - act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) + a(CHEBI:curcumin) decreases p(HGNC:IL6) - pmid:17493042 + pmid:29179999 - p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + a(CHEBI:curcumin) decreases p(HGNC:CXCL8) - pmid:18650430 + pmid:29179999 - p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:curcumin) decreases p(HGNC:IL12B) - pmid:18650430 + pmid:29179999 - p(HGNC:APBA1) decreases a(HBP:HBP00018) + a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB)) - pmid:18650430 + pmid:29179999 - p(HGNC:APBA1) regulates bp(HBP:HBP00073) + a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(Ph)) - pmid:21214928 + pmid:29179999 - bp(HBP:HBP00073) association p(HGNC:RAB6A) + a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) - pmid:22122372 + pmid:29179999 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:22122372 + pmid:28803412 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(CHEBI:curcumin) decreases a(HBP:HBP00092) - pmid:22122372 + pmid:28803412 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(CHEBI:curcumin) decreases a(HBP:HBP00016) @@ -25642,2630 +27037,2539 @@

Statements

pmid:30116051 - bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) + a(CHEBI:curcumin) decreases a(HBP:HBP00016) - pmid:18650430 + pmid:28803412 - p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:curcumin) decreases a(HBP:HBP00018) - pmid:18650430 + pmid:30116051 - p(HGNC:APBA2) decreases a(HBP:HBP00018) + a(CHEBI:curcumin) increases bp(GO:macroautophagy) - pmid:18650430 + pmid:30116051 - p(HGNC:APBA2) regulates bp(HBP:HBP00073) + a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) - pmid:18650430 + pmid:30116051 - p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) - pmid:18650430 + pmid:30116051 - p(HGNC:APBB1) decreases a(HBP:HBP00018) + a(CHEBI:curcumin) decreases a(HBP:HBP00022) - pmid:18650430 + pmid:30116051 - p(HGNC:APBB1) regulates bp(HBP:HBP00073) + a(CHEBI:curcumin) decreases a(HBP:HBP00009) - pmid:18650430 + pmid:27288790 - p(HGNC:APBB1) increases a(HBP:HBP00071) + p(HGNC:NOS2) increases path(MESH:Inflammation) - pmid:21214928 + pmid:23702978 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) + act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") - pmid:21214928 + pmid:27314526 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) + act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") - pmid:21214928 + pmid:27288790 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) + p(HGNC:NFKBIA, pmod(Ph)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:21214928 + pmid:29179999 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) + a(CHEBI:resveratrol) decreases p(HGNC:TNF) - pmid:21214928 + pmid:29179999 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) + a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) - pmid:21214928 + pmid:29179999 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) + a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) - pmid:21214928 + pmid:29179999 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) + a(CHEBI:resveratrol) decreases a(MESH:Interleukins) - pmid:21214928 + pmid:29179999 - a(HBP:HBP00071) increases bp(GO:"apoptotic process") + a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(Ph)) - pmid:18650430 + pmid:29179999 - p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(Ph)) - pmid:21214928 + pmid:29179999 - p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB)) - pmid:29758300 + pmid:29179999 - p(HGNC:SORL1) negativeCorrelation a(CHEBI:"amyloid-beta") + a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(Ph)) - pmid:29758300 + pmid:29179999 - p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") + a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:21214928 + pmid:29179999 - bp(GO:"synapse assembly") association p(HGNC:APP) + a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide") - pmid:21214928 + pmid:29179999 - bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) + a(CHEBI:resveratrol) decreases p(HGNC:NOS2) - + + + pmid:29179999 + + a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2") + - pmid:18650430 + pmid:22020111 - composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) + a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) - pmid:24653673 + pmid:22020111 - bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) + a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) - pmid:24653673 + pmid:30116051 - bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) + a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) - pmid:24653673 + pmid:30116051 - bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) + a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta") - pmid:26631930 + pmid:30116051 - bp(GO:neurogenesis) association p(HGNC:MAPT) + a(CHEBI:resveratrol) decreases p(HGNC:HTT) - pmid:26813123 + pmid:30116051 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) - pmid:26813123 + pmid:30116051 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + a(CHEBI:resveratrol) decreases act(p(HGNC:APP, frag("23_35"))) - pmid:26813123 + pmid:30116051 - p(HGNC:SLC5A7) increases a(CHEBI:choline) + a(CHEBI:resveratrol) increases r(FPLX:ATG4) - pmid:26813123 + pmid:30116051 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") - pmid:26813123 + pmid:30116051 - p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) + a(CHEBI:resveratrol) decreases p(HGNC:AGER) - pmid:17293005 + pmid:30116051 - p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta")) + a(CHEBI:resveratrol) decreases p(HGNC:MMP9) - pmid:17293005 + pmid:30116051 - p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta") + a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:17293005 + pmid:29062069 - p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha")) + a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA)) - pmid:17293005 + pmid:29062069 - p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) + a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1) + + - pmid:17293005 + pmid:27288790 - p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha") + act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(Ph)) + + - pmid:17293005 + pmid:23702978 - p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta") + act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) - pmid:17293005 + pmid:23178521 - p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) + p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) + a(CHEBI:pterostilbene) regulates p(HGNC:PPARA) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(CHEBI:pterostilbene) regulates p(FPLX:NFkappaB) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta")) + a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(Ph)) - pmid:17293005 + pmid:21718217 - p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha")) + p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") - pmid:17293005 + pmid:21718217 - p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta") + p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") - pmid:17293005 + pmid:18494933 - p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) + p(FPLX:JNK, pmod(Ph)) positiveCorrelation act(p(FPLX:JNK)) + + - pmid:17293005 + pmid:18494933 - p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta")) + act(p(FPLX:JNK)) positiveCorrelation p(FPLX:JNK, pmod(Ph)) - pmid:17293005 + pmid:18494933 - p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta") + p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER)) - pmid:17293005 + pmid:18494933 - p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha")) + p(FPLX:JNK) increases p(HGNC:DKK1) - pmid:17293005 + pmid:18494933 - p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) + act(p(FPLX:JNK)) increases p(HGNC:DKK1) - pmid:17293005 + pmid:27068745 - p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha") + act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1") - pmid:17293005 + pmid:27068745 - p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta") + act(p(FPLX:JNK)) association p(HGNC:CASP3) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) + a(PUBCHEM:44584733) decreases p(HGNC:PTGS2) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) + a(PUBCHEM:44584733) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response") + + + + - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta")) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha")) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(Ph)) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta") + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(Ph)) - pmid:17293005 + pmid:29179999 - p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(Ph)) - - - pmid:21214928 + pmid:27288790 - rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2) + p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB)) - pmid:21214928 + pmid:27288790 - a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) - pmid:26813123 + pmid:27288790 - a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") + act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) - pmid:14556719 + pmid:27288790 - a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) + act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:21214928 + pmid:30640040 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(p(HGNC:MAPK14)) increases a(HBP:"Tau aggregates") - pmid:21214928 + pmid:30640040 - a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") + p(HGNC:MAPK14) association a(PUBCHEM:11570805) - pmid:21214928 + pmid:30640040 - a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) + p(HGNC:MAPK14) association a(PUBCHEM:156422) - pmid:21214928 + pmid:30640040 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) + p(HGNC:MAPK14) association a(PUBCHEM:10341154) - pmid:21214928 + pmid:11943212 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) + p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:22122372 + pmid:27594586 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) + p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) - pmid:29215007 + pmid:27594586 - a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) + p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) - pmid:21214928 + pmid:24686445 - bp(HBP:HBP00077) increases p(HBP:HBP00063) + p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) - pmid:21214928 + pmid:29179999 - bp(HBP:HBP00077) increases p(HBP:HBP00064) + a(CHEBI:Salidroside) increases bp(GO:cognition) - pmid:21214928 + pmid:29179999 - bp(HBP:HBP00077) increases p(HBP:HBP00065) + a(CHEBI:Salidroside) regulates p(HGNC:TXN) - pmid:22122372 + pmid:29179999 - bp(HBP:HBP00077) increases a(HBP:HBP00063) + a(CHEBI:Salidroside) regulates p(HGNC:TXNIP) - pmid:22122372 + pmid:29179999 - bp(HBP:HBP00077) increases a(HBP:HBP00064) + a(CHEBI:Salidroside) regulates p(HGNC:RELA) - pmid:21214928 + pmid:29179999 - p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7) + a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) - pmid:21214928 + pmid:29179999 - p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:Salidroside) regulates p(HGNC:CHUK) - pmid:21214928 + pmid:29179999 - p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7) + a(CHEBI:Salidroside) regulates p(HGNC:IKBKB) - pmid:21214928 + pmid:29179999 - p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid") + a(PUBCHEM:155160) increases bp(GO:memory) - pmid:21214928 + pmid:29179999 - p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:155160) decreases a(HBP:"amyloid-beta aggregates") - pmid:21214928 + pmid:29179999 - p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064) + a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") - pmid:21214928 + pmid:29179999 - p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065) + a(PUBCHEM:155160) decreases path(MESH:Inflammation) - pmid:21214928 + pmid:29179999 - r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21214928 + pmid:29179999 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) + a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase")) - pmid:21214928 + pmid:29179999 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) + a(PUBCHEM:155160) decreases act(p(HGNC:BACE1)) - pmid:21214928 + pmid:29179999 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") + a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB)) - pmid:22122372 + pmid:27288790 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) + a(HBP:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex")) - pmid:22122372 + pmid:27288790 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) + a(HBP:"amyloid-beta aggregates") association p(HGNC:PTGS2) - pmid:22122372 + pmid:30444369 - a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) + a(HBP:"amyloid-beta aggregates") increases path(HBP:"mitochondrial dysfunction") - pmid:25514383 + pmid:30444369 - a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(HBP:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) - pmid:24653673 + pmid:30444369 - a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") + a(HBP:"amyloid-beta aggregates") association p(HGNC:CSNK1A1) - pmid:26751493 + pmid:19293145 - a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") + a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") - pmid:27796283 + pmid:24590577 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) + a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") - pmid:27796283 + pmid:25514383 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) + a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22833681 + pmid:22817713 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") + a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22833681 + pmid:24511233 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, PHF1") + a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") - pmid:22833681 + pmid:24590577 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases a(HBP:"Tau epitope, AT180") + a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") - pmid:22833681 + pmid:17009926 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases a(HBP:"Tau epitope, AT100") + a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7) - pmid:21214928 + pmid:27491084 - bp(GO:"signal transduction") association p(HGNC:APP) + a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB1) - pmid:17403556 + pmid:27491084 - bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) + a(HBP:"amyloid-beta aggregates") association p(HGNC:CRYAB) - pmid:29311797 + pmid:27491084 - bp(GO:"signal transduction") association p(HGNC:HSP90AB1) + a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB6) - pmid:21214928 + pmid:27491084 - bp(GO:"calcium ion homeostasis") association p(HGNC:APP) + a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) - pmid:19293145 + pmid:28877763 - bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) - pmid:29758300 + pmid:28877763 - bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) + a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) - pmid:21214928 + pmid:28877763 - bp(GO:"protein transport") association p(HGNC:APP) + a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) - pmid:23746257 + pmid:29179999 - bp(GO:"protein transport") association p(FPLX:HSP90) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death") - - - - - pmid:22122372 + pmid:27288790 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 32)) - - - - - pmid:22122372 + pmid:27288790 - complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 36)) - - - - - pmid:22122372 + pmid:27288790 - complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) - pmid:27068745 + pmid:27288790 - p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:BACE1) - pmid:21214928 + pmid:25652642 - p(HGNC:ITGB1) association p(HGNC:APP) + a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) - pmid:21214928 + pmid:27288790 - bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) + a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:"BACE1-AS") - pmid:21734277 + pmid:25652642 - bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18")) + a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) - - - - - pmid:21214928 + pmid:25652642 - complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) + a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pmid:25652642 - complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) + a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) - pmid:19491104 + pmid:25652642 - p(HGNC:KIF5B) isA complex(GO:"kinesin complex") + a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA)) - pmid:19491104 + pmid:25652642 - p(HGNC:KIF5B) association complex(GO:microtubule) + a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") - - - pmid:26813123 + pmid:25652642 - complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) - - - - - - - pmid:21214928 + pmid:25652642 - a(HBP:HBP00067) decreases bp(HBP:HBP00061) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") - pmid:22122372 + pmid:25652642 - a(HBP:HBP00067) decreases bp(HBP:HBP00061) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") - pmid:22122372 + pmid:25652642 - sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph)) - pmid:21214928 + pmid:29196815 - a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21214928 + pmid:19293145 - a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") + a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") - pmid:21214928 + pmid:26195256 - a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") + a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") - pmid:21214928 + pmid:19126755 - a(HBP:HBP00067) decreases bp(HBP:HBP00068) + a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00067) decreases bp(HBP:HBP00068) + a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21214928 + pmid:19293145 - a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation") + a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00067) decreases act(p(HGNC:CDK5)) + a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) - pmid:21214928 + pmid:19126755 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:21214928 + pmid:19126755 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:21214928 + pmid:25514383 - a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") - pmid:21214928 + pmid:25514383 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") - pmid:21214928 + pmid:25514383 - sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester") + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) - pmid:22122372 + pmid:25514383 - a(HBP:HBP00067) increases bp(GO:"cell adhesion") + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) - pmid:22122372 + pmid:25514383 - a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth") + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:22122372 + pmid:25514383 - a(HBP:HBP00067) increases bp(GO:"synapse assembly") + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:22122372 + pmid:25514383 - a(HBP:HBP00067) increases bp(GO:learning) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:22122372 + pmid:25514383 - a(HBP:HBP00067) increases bp(GO:memory) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") - - - - - - - pmid:21214928 + pmid:19721446 - composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067) + a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) - pmid:21214928 + pmid:19721446 - a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067)) + a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) - pmid:21214928 + pmid:22908190 - a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta") + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(HBP:neurotoxicity) - pmid:21214928 + pmid:22908190 - a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) + a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) - pmid:21214928 + pmid:19721446 - bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) - - - - - pmid:21214928 + pmid:19721446 - complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) - - - - - pmid:21214928 + pmid:14556719 - complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils") - pmid:19126755 + pmid:22908190 - bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) - pmid:26813123 + pmid:22908190 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(HBP:"APOE e4") - pmid:19293145 + pmid:22908190 - bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:19293145 + pmid:22908190 - bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:26195256 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta") - pmid:26813123 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) - pmid:21482353 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") - pmid:24511233 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24511233 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") - pmid:17009926 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") - pmid:26813123 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) - pmid:26813123 + pmid:30116051 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) + a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:AK1) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) + a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNC:AK1)) - pmid:21482353 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) + a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:Tauopathies) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:21482353 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:22040696 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") + a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(HGNC:AK3) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") + a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph)) - pmid:21482353 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 171)) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") + a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(ECCODE:"2.7.11.31") - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) - pmid:26813123 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(ECCODE:"2.7.11.31")) - pmid:24590577 + pmid:22419736 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph)) - pmid:24590577 + pmid:29626319 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) - pmid:21482353 + pmid:30444369 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) + p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) - pmid:21482353 + pmid:29179999 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) + a(CHEBI:lycopene) increases path(MESH:"Spatial Learning") - pmid:21482353 + pmid:29179999 - bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) + a(CHEBI:lycopene) increases bp(GO:memory) - pmid:11230871 + pmid:29179999 - bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) + a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") - pmid:21214928 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + a(CHEBI:genistein) decreases p(HGNC:TLR4) - pmid:21214928 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + a(CHEBI:genistein) decreases p(FPLX:NFkappaB) - pmid:22122372 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB)) - pmid:21214928 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") + a(CHEBI:genistein) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) - pmid:21214928 + pmid:19293145 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) + a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta")) - pmid:22122372 + pmid:19293145 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) + a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:21214928 + pmid:19293145 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) - pmid:22122372 + pmid:17009926 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) - pmid:22122372 + pmid:17009926 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN)) - pmid:27094130 + pmid:17009926 - sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) + a(CHEBI:genistein) regulates p(FPLX:CHRN) - pmid:29540553 + pmid:27314526 - p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3) + p(HGNC:TLR4) increases bp(GO:"cytokine secretion") - pmid:29559585 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac)) + a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:29559585 + pmid:29179999 - p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") + a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST)) - pmid:22122372 + pmid:29179999 - p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061) + a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(Ac)) - pmid:27094130 + pmid:29179999 - sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) + a(CHEBI:"gallic acid") decreases path(MESH:Inflammation) - pmid:24401760 + pmid:29179999 - p(HGNC:APP, frag("672_711")) biomarkerFor path(MESH:"Alzheimer Disease") + a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB)) - pmid:21214928 + pmid:29179999 - path(MESH:"Down Syndrome") increases a(HBP:HBP00018) + a(CHEBI:"gallic acid") decreases act(a(CHEBI:"amyloid-beta")) - pmid:17009926 + pmid:29179999 - path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) + a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) - pmid:17009926 + pmid:19126755 - path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) + a(CHEBI:galanthamine) decreases p(HGNC:ACHE) - pmid:26813123 + pmid:11230871 - path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") + a(CHEBI:galanthamine) increases act(p(HGNC:ACHE)) - pmid:22908190 + pmid:29179999 - path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") + a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine) - pmid:21214928 + pmid:29179999 - p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") + a(CHEBI:galanthamine) increases sec(a(CHEBI:acetylcholine)) - pmid:22122372 + pmid:29179999 - p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1)) - pmid:22908190 + pmid:29179999 - p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) + a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB)) - - - - - pmid:21214928 + pmid:30444369 - complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") + a(CHEBI:galanthamine) increases bp(GO:cognition) - pmid:21214928 + pmid:26813123 - complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") + a(CHEBI:galanthamine) increases bp(GO:cognition) - pmid:21214928 + pmid:30444369 - a(HBP:HBP00042) increases p(HGNC:TTR) + a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00042) increases p(HGNC:KL) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:22122372 + pmid:19126755 - a(HBP:HBP00042) increases bp(HBP:HBP00061) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21214928 + pmid:19126755 - bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21214928 + pmid:19126755 - a(HBP:HBP00024) increases bp(HBP:HBP00027) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - - - - - pmid:22122372 + pmid:19293145 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - pmid:22122372 + pmid:19126755 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration) - - - pmid:22122372 + pmid:19126755 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") - pmid:22122372 + pmid:19293145 - p(HBP:HBP00071) increases bp(GO:"cell death") + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:22122372 + pmid:19293145 - p(HBP:HBP00071) increases p(HGNC:TP53) + a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") - pmid:22122372 + pmid:19293145 - p(HBP:HBP00071) increases act(p(HGNC:TP53)) + act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) - pmid:22122372 + pmid:19293145 - p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") + a(CHEBI:galanthamine) increases p(HGNC:BCL2) - pmid:22122372 + pmid:24511233 - a(HBP:HBP00069) increases bp(HBP:HBP00061) + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00069) increases act(p(HGNC:CASP3)) + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) + a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) - pmid:22122372 + pmid:26813123 - a(HBP:HBP00070) increases bp(HBP:HBP00061) + a(CHEBI:galanthamine) decreases path(MESH:Death) - - - - - - - - - - - - - pmid:21214928 + pmid:25881725 - complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) + a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) - - - - - - - pmid:21214928 + pmid:25881725 - p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:galanthamine) increases bp(GO:learning) - pmid:21214928 + pmid:25881725 - p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta") + a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") - pmid:21214928 + pmid:25881725 - p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta") + a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) - - - - - - - pmid:21214928 + pmid:25881725 - complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta") + a(CHEBI:galanthamine) increases p(MGI:Chrna7) - - - - - - - - - - - pmid:21718217 + pmid:25881725 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:galanthamine) increases p(MGI:Chrna7) - pmid:29626319 + pmid:19721446 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) - pmid:29626319 + pmid:19721446 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) - pmid:29626319 + pmid:19126755 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) - pmid:29626319 + pmid:19293145 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) - pmid:29626319 + pmid:17009926 - act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine)) - pmid:28250274 + pmid:26813123 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) - pmid:30116051 + pmid:21482353 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) - pmid:29626319 + pmid:23038257 - p(HGNC:MME) increases bp(GO:behavior) + p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) - pmid:28250274 + pmid:17009926 - p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) + act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) - pmid:24653673 + pmid:26813123 - p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) - pmid:24653673 + pmid:26813123 - p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") - pmid:30640040 + pmid:11230871 - p(HGNC:EGFR) association a(PUBCHEM:24756910) + act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26195256 + pmid:26813123 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta") - pmid:26195256 + pmid:25514383 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Nephritis, Interstitial"), toLoc(MESH:Brain)) + act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") - pmid:26195256 + pmid:21482353 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) + act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:29626319 + pmid:18986241 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + p(HGNC:ACHE) association path(MESH:D058225) - pmid:29626319 + pmid:18986241 - p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) increases bp(GO:"GO:1990000") - pmid:29626319 + pmid:19126755 - p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - - - - - - - - - - - - - pmid:21214928 + pmid:24590577 - complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:22122372 + pmid:19126755 - bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:22122372 + pmid:24590577 - bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28420982 + pmid:19126755 - bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") + a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate") - pmid:19363271 + pmid:19126755 - bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) + a(CHEBI:acetylcholine) association bp(GO:signaling) - pmid:23531502 + pmid:24511233 - bp(GO:"neurofibrillary tangle assembly") positiveCorrelation act(a(CHEBI:"hydrogen peroxide")) + a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) - pmid:26655600 + pmid:24511233 - bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") + act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM1)) - pmid:17050703 + pmid:17009926 - bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) - pmid:16816118 + pmid:17009926 - bp(GO:"neurofibrillary tangle assembly") negativeCorrelation act(p(HBP:"20 S Proteasome")) + a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) - pmid:22122372 + pmid:17009926 - a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") - pmid:21718217 + pmid:26813123 - a(HBP:HBP00038) increases p(HGNC:CCL2) + a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) - pmid:21718217 + pmid:26813123 - a(HBP:HBP00038) increases bp(GO:"microglial cell activation") + a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) - pmid:21718217 + pmid:26813123 - act(a(HBP:HBP00038)) increases bp(GO:phagocytosis) + a(CHEBI:acetylcholine) regulates bp(GO:memory) - pmid:28019679 + pmid:26813123 - a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:acetylcholine) association bp(GO:memory) - pmid:24561250 + pmid:26813123 - a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") - pmid:21718217 + pmid:26813123 - a(HBP:HBP00022) decreases bp(GO:"synaptic signaling") + a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:21718217 + pmid:26813123 - a(HBP:HBP00022) increases bp(GO:"neuron death") + a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") - pmid:21214928 + pmid:26813123 - bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta") + a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) - pmid:19293145 + pmid:26813123 - bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta") + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - pmid:19126755 + pmid:21482353 - bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - pmid:19126755 + pmid:26813123 - bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:19293145 + pmid:21482353 - bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:19293145 + pmid:21787755 - bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:19293145 + pmid:26813123 - bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) + deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) - pmid:19293145 + pmid:26813123 - bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) + a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") - pmid:19293145 + pmid:26813123 - bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) + a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") - pmid:24590577 + pmid:26813123 - bp(GO:"MAPK cascade") increases p(HGNC:BACE1) + a(CHEBI:acetylcholine) association bp(GO:learning) - pmid:21214928 + pmid:26813123 - bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta") + a(CHEBI:acetylcholine) association bp(GO:cognition) - pmid:19126755 + pmid:11230871 - bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) + a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) - pmid:19293145 + pmid:16273023 - bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process") + a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) - pmid:24590577 + pmid:25514383 - bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) + tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") - pmid:24590577 + pmid:25514383 - bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing") + a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR")) - pmid:27594586 + pmid:25514383 - bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) + act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - - - - - pmid:21214928 + pmid:21482353 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061) + a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR")) @@ -28274,881 +29578,787 @@

Statements

pmid:19721446 - p(HGNC:DNM1) association p(HGNC:CHRNB2) + a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") + + + + - pmid:29590627 + pmid:29179999 - act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - pmid:29590627 + pmid:17009926 - act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") - pmid:29590627 + pmid:17009926 - act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") - pmid:21214928 + pmid:17009926 - bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") - pmid:26813123 + pmid:17009926 - bp(MESH:"Synaptic Transmission") association bp(GO:memory) + p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") - pmid:14556719 + pmid:17009926 - bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) + p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") - pmid:21214928 + pmid:17009926 - a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") - pmid:14556719 + pmid:17009926 - bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) + p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") - pmid:23746257 + pmid:17009926 - bp(GO:"cell death") negativeCorrelation bp(HBP:Proteostasis) + act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") - pmid:18930136 + pmid:17009926 - bp(GO:"cell death") negativeCorrelation a(GO:aggresome) + p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") - pmid:24561250 + pmid:17009926 - bp(GO:"cell death") increases sec(a(CHEBI:ATP)) + p(FPLX:CHRN) association path(MESH:Attention) - - - - - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") + p(FPLX:CHRN) association bp(GO:learning) - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) + p(FPLX:CHRN) association bp(GO:memory) - pmid:21214928 + pmid:11230871 - complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + p(FPLX:CHRN) association bp(GO:memory) - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) association bp(GO:"developmental process") - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + p(FPLX:CHRN) association path(MESH:Schizophrenia) - - - - - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") + p(FPLX:CHRN) association path(MESH:Schizophrenia) - pmid:21214928 + pmid:21482353 - complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067) + act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) - pmid:21214928 + pmid:11230871 - complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + p(FPLX:CHRN) association path(MESH:Schizophrenia) - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) association path(MESH:Epilepsy) - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + p(FPLX:CHRN) association path(MESH:Epilepsy) - - - - - pmid:21214928 + pmid:11230871 - complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") + p(FPLX:CHRN) association path(MESH:Epilepsy) - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067) + p(FPLX:CHRN) association path(MESH:"Autistic Disorder") - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") - pmid:21214928 + pmid:17009926 - p(HGNC:RAB6A) association bp(HBP:HBP00073) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21214928 + pmid:17009926 - bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:17009926 - bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:11230871 - bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") - pmid:27260836 + pmid:11230871 - bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:21214928 + pmid:17009926 - complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) + p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") - - - - - - - - - pmid:21214928 + pmid:26472524 - complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) + act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") - - - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - - - - - pmid:21214928 + pmid:17009926 - complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:21214928 + pmid:26472524 - complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067)) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:21214928 + pmid:26472524 - a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:19293145 + pmid:17009926 - a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:11230871 + pmid:17009926 - a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:21214928 + pmid:26472524 - a(CHEBI:estrogen) increases sec(a(HBP:HBP00067)) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:19293145 + pmid:26472524 - a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4")) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:11230871 + pmid:17009926 - a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:21214928 + pmid:17009926 - act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:21214928 + pmid:17009926 - p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:21214928 + pmid:26472524 - p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:21214928 + pmid:17009926 - p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) + act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22122372 + pmid:26472524 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22122372 + pmid:26472524 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:22122372 + pmid:25514383 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") - pmid:21214928 + pmid:17009926 - p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") + act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) - pmid:8282104 + pmid:17009926 - p(HGNC:PRKACA) association a(GO:microtubule) + p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)")) - pmid:8282104 + pmid:26472524 - p(HGNC:PRKACA) association a(HBP:HBP00006) + act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) - pmid:21214928 + pmid:17009926 - p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:21214928 + pmid:17009926 - a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") + p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) - pmid:21214928 + pmid:17009926 - a(CHEBI:testosterone) decreases r(HGNC:BACE1) + act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") - pmid:21214928 + pmid:17009926 - a(CHEBI:testosterone) decreases p(HGNC:BACE1) + act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") - pmid:21214928 + pmid:17009926 - a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) + p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") - pmid:21214928 + pmid:17009926 - a(CHEBI:testosterone) decreases p(HGNC:PSEN1) + p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00078) association p(HGNC:APP) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") - pmid:22122372 + pmid:17009926 - a(HBP:HBP00079) association p(HGNC:APP) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") - - - - - - - pmid:22122372 + pmid:17009926 - a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") - - - - - - - pmid:22122372 + pmid:11230871 - composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") + p(FPLX:CHRN) association path(MESH:"Parkinson Disease") - - - - - - - - - - - - - pmid:29221819 + pmid:17009926 - p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) + p(FPLX:CHRN) association bp(GO:"response to pain") - - - - - - - - - - - - - - - - - - - - - - - - - pmid:22122372 + pmid:17009926 - p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) + p(FPLX:CHRN) association path(MESH:Anxiety) - pmid:29758300 + pmid:11230871 - p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") + p(FPLX:CHRN) association path(MESH:Anxiety) - pmid:22908190 + pmid:17009926 - p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + p(FPLX:CHRN) association path(MESH:Depression) - pmid:29758300 + pmid:11230871 - p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) + p(FPLX:CHRN) association path(MESH:Depression) - pmid:14556719 + pmid:17009926 - p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) + act(p(FPLX:CHRN)) increases path(MESH:Arousal) - pmid:14556719 + pmid:28445721 - p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) association path(MESH:Arousal) - pmid:22908190 + pmid:17009926 - p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") + act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") - pmid:22908190 + pmid:26472524 - p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites)) + p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22908190 + pmid:26472524 - p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") + p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:22908190 + pmid:26472524 - p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) + p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22122372 + pmid:26472524 - p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) + p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:14556719 + pmid:26813123 - p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) + p(FPLX:CHRN) increases bp(GO:cognition) - pmid:14556719 + pmid:25514383 - p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") + p(FPLX:CHRN) regulates bp(GO:cognition) - - - - - - - - - - - pmid:22122372 + pmid:28445721 - a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) + p(FPLX:CHRN) association bp(GO:cognition) - - - - - pmid:22122372 + pmid:28445721 - complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) + p(FPLX:CHRN) increases bp(GO:cognition) - - - - - pmid:22122372 + pmid:28445721 - complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) + p(FPLX:CHRN) association bp(GO:cognition) - - - - - pmid:22122372 + pmid:11230871 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) + p(FPLX:CHRN) association bp(GO:cognition) - pmid:22122372 + pmid:26813123 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) + p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration) + + - pmid:22122372 + pmid:25514383 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) + p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") @@ -29165,22 +30375,8 @@

Statements

- - - pmid:22122372 - - complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") - - - - - pmid:22122372 - - complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") - - @@ -29191,5544 +30387,5422 @@

Statements

- pmid:19491104 + pmid:25514383 - act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) + p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") - pmid:19491104 + pmid:25514383 - p(HGNC:KLC1) isA complex(GO:"kinesin complex") + p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") - pmid:19491104 + pmid:25514383 - p(HGNC:KLC1) association p(HGNC:MAPK8IP1) + p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") - - - - - - - - - - - - - - - - - - - - - pmid:22122372 + pmid:25514383 - complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta") + act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") - - - - - - - - - pmid:22122372 + pmid:25514383 - p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) + p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") - pmid:22122372 + pmid:28445721 - p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) + p(FPLX:CHRN) association path(MESH:Motivation) - pmid:22122372 + pmid:28445721 - p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) + act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) - pmid:22122372 + pmid:28445721 - p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) + p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") - pmid:22122372 + pmid:28445721 - p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) + p(FPLX:CHRN) increases bp(GO:"dopamine secretion") - pmid:22122372 + pmid:28445721 - p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) + p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") - pmid:22122372 + pmid:21482353 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") + + - pmid:22122372 + pmid:21482353 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:22122372 + pmid:11230871 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:26631930 + pmid:21482353 - p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) - pmid:26631930 + pmid:21482353 - p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) - pmid:22122372 + pmid:21482353 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + p(FPLX:CHRN) regulates p(HGNC:LYNX1) - pmid:22122372 + pmid:21482353 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) - pmid:22122372 + pmid:21482353 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) - - - + + + pmid:21482353 + + p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") + - pmid:22122372 + pmid:21482353 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) + p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) - pmid:22122372 + pmid:21482353 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) + p(FPLX:CHRN) increases act(p(FPLX:NOS)) - pmid:22122372 + pmid:11230871 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) + p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") - pmid:22122372 + pmid:11230871 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) + p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") - pmid:22122372 + pmid:11230871 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") - pmid:22122372 + pmid:11230871 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) + p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) - pmid:22122372 + pmid:11230871 - act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") + p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") - - - + + + pmid:11230871 + + p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + - pmid:22122372 + pmid:11230871 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) + p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") - - - pmid:22122372 + pmid:21787755 - complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668)) + p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") - pmid:22122372 + pmid:21787755 - complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073) + p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") - pmid:19491104 + pmid:22020111 - act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) + p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2)) - pmid:19491104 + pmid:22020111 - p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") + p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19491104 + pmid:29179999 - p(HGNC:MAPK8IP1) association p(HGNC:KLC1) + a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide") - pmid:27094130 + pmid:29179999 - p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711"))) + a(PUBCHEM:14193399) decreases p(HGNC:TNF) - pmid:27094130 + pmid:29179999 - p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713"))) + a(PUBCHEM:14193399) decreases p(HGNC:IL1A) - pmid:22122372 + pmid:29179999 - a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) + a(PUBCHEM:14193399) decreases p(HGNC:PTGS2) - - - - - pmid:22122372 + pmid:29179999 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") + a(PUBCHEM:14193399) decreases p(HGNC:NOS2) - pmid:22122372 + pmid:29179999 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) + a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB)) - pmid:22122372 + pmid:29179999 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") + a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14)) - pmid:18494933 + pmid:29179999 - deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) + a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species") - - - - - - - - - - - - - pmid:19126755 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) - pmid:24590577 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) - pmid:19126755 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(PUBCHEM:73078) decreases a(MESH:Cytokines) - pmid:24590577 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) - pmid:19126755 + pmid:29179999 - a(CHEBI:acetylcholine) decreases path(MESH:"Heart Rate") + a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:19126755 + pmid:29179999 - a(CHEBI:acetylcholine) association bp(GO:signaling) + a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) - pmid:24511233 + pmid:29179999 - a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) + a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) - pmid:24511233 + pmid:29179999 - act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM1)) + a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") - pmid:17009926 + pmid:29179999 - deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) + a(PUBCHEM:73078) increases bp(GO:memory) - pmid:17009926 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) + a(PUBCHEM:73078) decreases p(HGNC:IL1B) - pmid:17009926 + pmid:29179999 - a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") + a(PUBCHEM:73078) decreases p(HGNC:TNF) - pmid:26813123 + pmid:27288790 - a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) + a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) - pmid:26813123 + pmid:27288790 - a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) + a(MESH:Cytokines) increases m(MIRBASE:"hsa-mir-155") - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) regulates bp(GO:memory) + a(CHEBI:berberine) decreases path(MESH:Inflammation) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) association bp(GO:memory) + a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") + a(CHEBI:berberine) decreases p(HGNC:RELA) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) + a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(Ph)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:berberine) decreases act(p(HGNC:MAPK14)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) + a(CHEBI:berberine) decreases act(p(FPLX:ERK)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) + a(CHEBI:berberine) decreases act(p(FPLX:AKT)) - pmid:21482353 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) + a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) + a(CHEBI:oridonin) increases bp(GO:cognition) - pmid:21482353 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) + a(CHEBI:oridonin) decreases path(MESH:Inflammation) - pmid:21787755 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:22807490 - deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:26010758 - a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:26010758 - a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:26010758 - a(CHEBI:acetylcholine) association bp(GO:learning) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:29179999 - a(CHEBI:acetylcholine) association bp(GO:cognition) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") - pmid:11230871 + pmid:21958873 - a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") - pmid:16273023 + pmid:21958873 - a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") - pmid:25514383 + pmid:26010758 - tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") - pmid:25514383 + pmid:29179999 - a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR")) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:25514383 + pmid:21958873 - act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21482353 + pmid:21958873 - a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR")) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:19721446 + pmid:21958873 - a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:19126755 + pmid:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24511233 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:19721446 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response") - - - - - - - - - - - pmid:24511233 + pmid:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:24511233 + pmid:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:24590577 + pmid:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) + a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) + a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) + a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") + a(CHEBI:Anatabine) decreases p(HGNC:NOS2) - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") + a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) - pmid:24590577 + pmid:22807490 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) + a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") - pmid:24590577 + pmid:21958873 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") + a(CHEBI:Anatabine) causesNoChange sec(p(HGNC:LDHA)) - pmid:19126755 + pmid:21958873 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") + a(CHEBI:Anatabine) decreases sec(p(HBP:"sAPP-beta")) - pmid:19126755 + pmid:21958873 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine") + a(CHEBI:Anatabine) causesNoChange sec(p(HBP:"sAPP-alpha")) - pmid:19126755 + pmid:21958873 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:19126755 + pmid:21958873 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:19721446 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19293145 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") + a(CHEBI:Anatabine) decreases r(HGNC:BACE1) - pmid:19126755 + pmid:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) + a(CHEBI:Anatabine) decreases r(HGNC:BACE1) - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") + a(CHEBI:Anatabine) decreases p(HGNC:BACE1) - pmid:19126755 + pmid:21958873 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") + a(CHEBI:Anatabine) decreases p(HGNC:CRP) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:19126755 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta")) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta")) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) - pmid:19293145 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity) + a(CHEBI:Anatabine) decreases p(MGI:Tnf) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) + a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium")) + a(CHEBI:Anatabine) decreases p(MGI:Tnf) - pmid:19293145 + pmid:23178521 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) + a(CHEBI:Anatabine) decreases p(MGI:Il6) - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) + a(CHEBI:Anatabine) decreases p(MGI:Il6) - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) + a(CHEBI:Anatabine) decreases a(MESH:Cytokines) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") + a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) + a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) + a(CHEBI:Anatabine) decreases path(MESH:Paralysis) - pmid:19293145 + DOI:10.4172/2168-975X.1000126 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta")) + a(CHEBI:Anatabine) decreases path(MESH:Paralysis) - pmid:19293145 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") + a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") - pmid:19293145 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:Anatabine) decreases p(MGI:Il1b) - pmid:24511233 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) decreases p(MGI:Il1b) - pmid:19721446 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) decreases p(MGI:Il17a) - pmid:19721446 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") + a(CHEBI:Anatabine) decreases p(MGI:Il17a) - pmid:19721446 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") + a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) - pmid:19721446 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine)) + a(CHEBI:Anatabine) decreases p(MGI:Ifng) - pmid:19721446 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin)) + a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) - pmid:19721446 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)")) + a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) - pmid:19721446 + pmid:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) + a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) - pmid:19721446 + pmid:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") + a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) - pmid:19126755 + pmid:23383175 - a(TAXONOMY:41956) increases a(CHEBI:Muscarine) + a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) - pmid:19126755 + pmid:23383175 - a(TAXONOMY:33113) increases a(CHEBI:atropine) + a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:19126755 + pmid:23383175 - a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + a(CHEBI:Anatabine) decreases a(MESH:Microglia) - pmid:19126755 + pmid:23383175 - a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:19126755 + pmid:23383175 - a(CHEBI:atropine) decreases bp(GO:"cell adhesion") + a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:26813123 + pmid:23383175 - a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) + a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") - pmid:26751493 + DOI:10.4172/2168-975X.1000126 - p(FPLX:PLC) association p(HBP:"projection domain") + a(CHEBI:Anatabine) increases bp(GO:"motor behavior") - pmid:26751493 + DOI:10.4172/2168-975X.1000126 - p(FPLX:PLC) association a(HBP:"projection domain") + a(CHEBI:Anatabine) increases bp(GO:"motor behavior") - pmid:29626319 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) + a(CHEBI:Anatabine) decreases path(MESH:Anxiety) - pmid:29758300 + pmid:26010758 - a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) + a(CHEBI:Anatabine) increases path(MESH:Anxiety) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:Anatabine) increases path(MESH:"Spatial Learning") - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle") - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") - pmid:19293145 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") - pmid:19293145 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:19721446 + DOI:10.4172/2168-975X.1000126 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(Ph, Ser, 473)) - pmid:19721446 + pmid:26010758 - act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:Anatabine) decreases path(MESH:Gliosis) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) association path(HBP:neurotoxicity) + a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7)) - pmid:19293145 + pmid:26010758 - a(CHEBI:nicotine) decreases path(HBP:neurotoxicity) + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + a(CHEBI:Anatabine) decreases bp(GO:locomotion) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations") - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Anatabine) decreases p(HGNC:AIF1) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") + a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation") - pmid:18174175 + pmid:26010758 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") + a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR") + a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) + a(CHEBI:Anatabine) decreases r(HGNC:PTGS2) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) + a(CHEBI:Anatabine) decreases r(HGNC:NOS2) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) + a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(Ph)) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:PKA)) + a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species") - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:PKC)) + a(CHEBI:"vitamin D") decreases path(MESH:Inflammation) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) + a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"reactive oxygen species") - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB)) + a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2)) + a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1)) + a(CHEBI:"alpha-tocopherol") decreases a(MESH:Cytokines) - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) + a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"nitric oxide") - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3)) + a(CHEBI:"alpha-tocopherol") increases bp(GO:memory) - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) association a(MESH:Skin) + a(CHEBI:"alpha-tocopherol") decreases path(MESH:"Oxidative Stress") - pmid:19126755 + pmid:29179999 - act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") + a(CHEBI:"alpha-tocopherol") decreases act(p(FPLX:NFkappaB)) - pmid:23178521 + pmid:29179999 - a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") + a(CHEBI:"alpha-tocopherol") decreases p(HGNC:NOS2) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") + a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL6) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") + a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL1B) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) decreases sec(p(HGNC:TNF)) + a(CHEBI:"alpha-tocopherol") decreases bp(GO:"microglial cell activation") - pmid:19293145 + pmid:21718217 - a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) + bp(GO:"microglial cell activation") association a(HBP:HBP00089) - pmid:19126755 + pmid:21718217 - act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") + bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) - pmid:19126755 + pmid:26010758 - a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") + bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) - pmid:19126755 + pmid:28877763 - a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) + bp(GO:"microglial cell activation") positiveCorrelation act(p(HGNC:SYK)) - pmid:19126755 + pmid:27314526 - a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398")) + bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) - pmid:19126755 + pmid:27314526 - a(CHEBI:nicotine) decreases bp(GO:"neuron death") + bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) - pmid:19126755 + pmid:27314526 - a(CHEBI:nicotine) decreases bp(GO:"neuron death") + bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) - pmid:19126755 + pmid:27314526 - a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine)) + a(PUBCHEM:444795) decreases path(MESH:Inflammation) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:dopamine) + a(PUBCHEM:444795) decreases p(HGNC:IL6) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) + a(PUBCHEM:444795) decreases p(HGNC:IL12B) - pmid:19721446 + pmid:29179999 - a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine)) + a(PUBCHEM:444795) decreases p(HGNC:TNF) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") + a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB)) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases path(MESH:Craving) + a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) increases path(MESH:Anxiety) + a(PUBCHEM:444795) decreases p(HGNC:BACE1) - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) + a(PUBCHEM:3086007) decreases a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7) + a(PUBCHEM:441921) decreases a(CHEBI:"amyloid-beta") - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) + a(PUBCHEM:9918693) decreases a(CHEBI:"amyloid-beta") - pmid:26472524 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) + a(PUBCHEM:441923) decreases a(CHEBI:"amyloid-beta") - pmid:19126755 + pmid:29179999 - a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR") + a(PUBCHEM:441923) decreases r(HGNC:TLR3) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases p(HGNC:TLR3) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases r(HGNC:TLR4) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases p(HGNC:TLR4) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases p(FPLX:NFkappaB) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases r(HGNC:TRAF6) - pmid:19721446 + pmid:29179999 - a(CHEBI:nicotine) association bp(MESH:Neuroprotection) + a(PUBCHEM:441923) decreases p(HGNC:TRAF6) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) + a(PUBCHEM:441923) decreases p(HGNC:TNF) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(PUBCHEM:441923) decreases p(HGNC:IFNB1) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) + a(PUBCHEM:24721561) decreases bp(GO:"neuron death") - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) + a(PUBCHEM:24721561) increases bp(GO:learning) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") + a(PUBCHEM:24721561) increases bp(GO:memory) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph)) + a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB)) - pmid:19293145 + pmid:26631930 - act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) + p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63)) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) + a(PUBCHEM:164676) decreases act(p(HGNC:NOS2)) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph)) + a(PUBCHEM:164676) decreases act(p(HGNC:MMP2)) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:164676) decreases act(p(HGNC:RELA)) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:164676) decreases bp(GO:"apoptotic process") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) + a(PUBCHEM:164676) decreases path(MESH:Inflammation) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(HGNC:BAD)) + a(PUBCHEM:164676) decreases bp(GO:"neuron death") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) + a(PUBCHEM:164676) decreases p(HGNC:GFAP) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:164676) decreases p(FPLX:NFkappaB) - pmid:23178521 + pmid:29179999 - a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:164676) increases p(HGNC:RBFOX3) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph)) + a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies") - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph)) + a(PUBCHEM:164676) increases p(FPLX:IKB) - pmid:19293145 + pmid:27594586 - act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph)) + act(p(HGNC:MMP2)) increases bp(GO:"neuron death") - pmid:19293145 + pmid:27594586 - a(CHEBI:nicotine) increases act(g(HGNC:NIN)) + p(HGNC:MMP2) increases bp(GO:"neuron death") - pmid:19293145 + pmid:29626319 - a(CHEBI:nicotine) increases act(g(HGNC:PTGS2)) + act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:19293145 + pmid:25652642 - a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)") + p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) + + - pmid:19293145 + pmid:27288790 - a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") + deg(p(FPLX:IKB)) increases act(p(FPLX:NFkappaB)) + + + + - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") + a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) + a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB)) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) + a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) + a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:19293145 + pmid:28019679 - a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") + a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) - pmid:19293145 + pmid:28019679 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") + a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") + a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) association p(FPLX:ERK) + a(PUBCHEM:440312) decreases p(HGNC:TNF) - pmid:19293145 + pmid:29179999 - act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) + a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2") - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") + a(PUBCHEM:440312) decreases p(HGNC:NOS2) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta")) + a(PUBCHEM:440312) decreases p(HGNC:PTGS2) - pmid:19293145 + pmid:29179999 - a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma") + a(PUBCHEM:440312) decreases act(p(HGNC:LOX)) - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species") - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + a(PUBCHEM:440312) decreases act(p(FPLX:ERK)) - pmid:28445721 + pmid:29179999 - a(CHEBI:nicotine) regulates p(FPLX:CHRN) + a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14)) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases p(FPLX:CHRN) + a(CHEBI:Geniposide) decreases act(p(FPLX:ERK)) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases p(FPLX:CHRN) + a(CHEBI:Geniposide) decreases act(p(FPLX:IKB)) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) + a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB)) - pmid:21787755 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + a(CHEBI:Geniposide) decreases p(HGNC:TNF) - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(CHEBI:Geniposide) decreases p(HGNC:IL1B) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(CHEBI:Geniposide) decreases a(CHEBI:"amyloid-beta") - pmid:11230871 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") - pmid:11230871 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") - pmid:17009926 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") + a(PUBCHEM:102336202) decreases p(HGNC:NOS2) - pmid:26813123 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) + a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:102336202) increases r(HGNC:IL4) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:102336202) decreases a(MESH:Cytokines) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide") - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(PUBCHEM:102336202) decreases p(HGNC:IL1B) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta") + a(PUBCHEM:102336202) decreases p(HGNC:TNF) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(PUBCHEM:102336202) decreases act(p(FPLX:ERK)) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB)) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death") - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK)) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14)) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers") + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB)) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") + a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species") - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") + a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide") - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") + a(CHEBI:"1,8-cineole") decreases p(HGNC:TNF) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") + a(CHEBI:"1,8-cineole") decreases p(HGNC:IL1B) - pmid:19721446 + pmid:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") + a(CHEBI:"1,8-cineole") decreases p(HGNC:IL6) - pmid:25514383 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:"1,8-cineole") decreases p(HGNC:NOS2) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:"1,8-cineole") decreases p(HGNC:PTGS2) - pmid:28445721 + pmid:29179999 - a(CHEBI:nicotine) increases surf(p(HBP:HBP00174)) + a(CHEBI:"1,8-cineole") decreases p(FPLX:NFkappaB) - pmid:28445721 + pmid:29179999 - a(CHEBI:nicotine) increases a(HBP:HBP00174) + a(PUBCHEM:442534) increases bp(GO:memory) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) + a(PUBCHEM:442534) decreases a(HBP:"amyloid-beta aggregates") - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) + a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:cognition) + a(PUBCHEM:442534) decreases act(p(FPLX:GSK3)) - pmid:19721446 + pmid:29179999 - a(CHEBI:nicotine) increases bp(GO:cognition) + a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(PUBCHEM:442534) decreases p(HGNC:TNF) - pmid:21482353 + pmid:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(PUBCHEM:442534) decreases p(HGNC:IL1B) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:18174175 + pmid:8282104 - a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR") + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR") + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) + p(FPLX:GSK3) association a(GO:microtubule) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) + p(FPLX:GSK3) association a(HBP:HBP00006) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) + p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) - pmid:21482353 + pmid:8282104 - a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:11230871 + pmid:27288790 - a(CHEBI:nicotine) increases bp(GO:learning) + bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB) - pmid:11230871 + pmid:12428809 - a(CHEBI:nicotine) increases path(MESH:Attention) + bp(GO:"negative regulation of neuron apoptotic process") association sec(p(HGNC:APP)) - pmid:19721446 + pmid:27288790 - a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") + bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) - pmid:19721446 + pmid:24590577 - act(a(CHEBI:nicotine)) association p(HGNC:CHRNB4) + bp(GO:"neuron differentiation") association p(HGNC:CHRM1) - pmid:19721446 + pmid:28884684 - act(a(CHEBI:nicotine)) association p(HGNC:CHRNA2) + bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) - pmid:19721446 + pmid:27288790 - act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5) + bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB) - pmid:19721446 + pmid:27288790 - act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) + bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:30444369 - a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) + bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) - pmid:18174175 + pmid:17009926 - a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) - pmid:23178521 + pmid:17009926 - a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB)) + bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) - pmid:19126755 + pmid:24590577 - a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) - pmid:19126755 + pmid:30106381 - a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) - pmid:19126755 + pmid:22908190 - a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:19126755 + pmid:22908190 - a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) + bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) - pmid:21482353 + pmid:22908190 - a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) - pmid:19126755 + pmid:26631930 - bp(GO:signaling) association a(CHEBI:acetylcholine) + bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) - pmid:19126755 + pmid:27288790 - act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) + p(FPLX:IKB, pmod(Ph)) increases deg(p(FPLX:IKB)) - pmid:26813123 + pmid:27288790 - p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) + p(FPLX:IKB, pmod(Ph)) increases act(p(FPLX:NFkappaB)) - pmid:19293145 + pmid:27288790 - p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) + p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) increases act(p(HGNC:RELA)) - - - pmid:26813123 + pmid:27288790 - act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") + bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species") - pmid:26813123 + pmid:27288790 - act(p(HGNC:CHAT)) decreases path(MESH:Dementia) + bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species") - pmid:16273023 + pmid:17009926 - act(p(HGNC:CHAT), ma(cat)) increases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) - pmid:24590577 + pmid:17009926 - p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) - pmid:25514383 + pmid:11230871 - act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) - pmid:18986241 + pmid:26837465 - act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) - pmid:19721446 + pmid:19277525 - p(HGNC:CHAT) increases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") - pmid:18986241 + pmid:22908190 - act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") - - - - - - - pmid:28002468 + pmid:22299660 - a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") - pmid:17009926 + pmid:26631930 - a(CHEBI:choline) increases act(p(FPLX:CHRN)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") - pmid:26813123 + pmid:22299660 - a(CHEBI:choline) increases a(CHEBI:acetylcholine) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2)) - pmid:26088141 + pmid:29758300 - act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:30145931 - act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:17403556 - a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:25374103 - a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:26631930 - a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:24401760 - a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:29758300 - a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:21482353 + pmid:25374103 - a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:21482353 + pmid:26631930 - a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19721446 + pmid:29758300 - a(CHEBI:choline) increases bp(MESH:Neuroprotection) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") - pmid:19721446 + pmid:21882945 - a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") - pmid:26813123 + pmid:25374103 - p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") + tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(HBP:"Tau aggregates") - pmid:26813123 + pmid:28877763 - p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(HBP:"Tau aggregates") - pmid:26813123 + pmid:26631930 - p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") - pmid:26813123 + pmid:29758300 - p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") - pmid:26813123 + pmid:30145931 - p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) - pmid:19721446 + pmid:22611162 - p(HGNC:CHRNA2) association act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") - pmid:26813123 + pmid:26631930 - p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") - - - pmid:11230871 + pmid:22611162 - p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") - pmid:11230871 + pmid:22611162 - p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") - pmid:19721446 + pmid:25374103 - p(HGNC:CHRNA3) association path(MESH:Craving) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:19721446 + pmid:28877763 - p(HGNC:CHRNA3) association path(MESH:Recurrence) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association act(p(HGNC:SYK)) - pmid:19126755 + pmid:26458742 - p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:HBP00006) - pmid:11230871 + pmid:26458742 - p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:19126755 + pmid:26631930 - p(HGNC:CHRNA4) association p(HGNC:PTGS2) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:19293145 + pmid:26631930 - p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:17009926 + pmid:26631930 - p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:19293145 + pmid:26631930 - act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:19293145 + pmid:26631930 - act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin") - pmid:19721446 + pmid:26631930 - p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(HBP:Neurodegeneration) - pmid:19293145 + pmid:26631930 - p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(a(GO:synapse)) - pmid:23038257 + pmid:23487739 - p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule) - pmid:23038257 + pmid:19732809 - p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") + p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - pmid:17009926 + pmid:30106381 - p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:autophagy) association p(HGNC:ADNP) - - - pmid:26813123 + pmid:30106381 - p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") + bp(GO:autophagy) association p(HGNC:ADNP) - - - pmid:11230871 + pmid:30106381 - p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) + bp(GO:autophagy) association a(PUBCHEM:9832404) - - - pmid:19126755 + pmid:30106381 - p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") + bp(GO:autophagy) association p(HGNC:MTOR) - pmid:26813123 + pmid:29758300 - p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") + bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) - - - pmid:19721446 + pmid:22020111 - p(HGNC:CHRNA5) association act(a(CHEBI:nicotine)) + bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) - pmid:26813123 + pmid:29758300 - p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") + bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21787755 + pmid:22908190 - p(HGNC:CHRNA6) association path(MESH:Reward) + bp(GO:autophagy) association path(MESH:"Alzheimer Disease") - pmid:21787755 + pmid:22908190 - p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") + bp(GO:autophagy) association path(MESH:"Alzheimer Disease") - pmid:21787755 + pmid:29758300 - p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) + bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:19126755 + pmid:22908190 - p(HGNC:CHRNA7) association a(MESH:Neurons) + bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:19126755 + pmid:29758300 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) + bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:19126755 + pmid:18930136 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:19126755 + pmid:29758300 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) + bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) - - - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") + bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") + bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) - pmid:19126755 + pmid:29758300 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + bp(GO:autophagy) association p(HGNC:MAPT, pmod(Ph)) - pmid:19293145 + pmid:29758300 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:22040696 + pmid:29626319 - p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:19126755 + pmid:29758300 - act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") + bp(GO:autophagy) association a(HBP:"Tau aggregates") - pmid:19126755 + pmid:29758300 - act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") + bp(GO:autophagy) increases deg(p(HGNC:SNCA)) - pmid:19126755 + pmid:18930136 - act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) + bp(GO:autophagy) increases deg(p(HGNC:SNCA)) - pmid:19126755 + pmid:29758300 - p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) + bp(GO:autophagy) decreases a(CHEBI:lipid) - pmid:19293145 + pmid:29758300 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) + bp(GO:autophagy) increases deg(a(CHEBI:lipid)) - pmid:17009926 + pmid:29758300 - act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) + bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) - pmid:19126755 + pmid:29758300 - p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) + bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) - pmid:19126755 + pmid:29758300 - act(p(HGNC:CHRNA7)) association bp(GO:cognition) + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - pmid:19721446 + pmid:30145931 - p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) + bp(GO:autophagy) decreases p(HGNC:MAPT) - pmid:19721446 + pmid:24027553 - act(p(HGNC:CHRNA7)) increases bp(GO:cognition) + bp(GO:autophagy) association deg(p(HGNC:MAPT)) - pmid:19126755 + pmid:23528736 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - pmid:19293145 + pmid:25374103 - p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - pmid:11230871 + pmid:29626319 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - pmid:22040696 + pmid:29626319 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - pmid:29191965 + pmid:22908190 - p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:19126755 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) + bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:19126755 + pmid:18930136 - act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:19126755 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:19293145 + pmid:22908190 - p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") + bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") - pmid:19293145 + pmid:22908190 - p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta")) + bp(GO:autophagy) increases deg(p(HBP:"protein aggregates", pmod(Ub))) - pmid:19293145 + pmid:22908190 - p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) - pmid:19293145 + pmid:22908190 - p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta")) - pmid:17009926 + pmid:22908190 - p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") + bp(GO:autophagy) decreases path(MESH:Tauopathies) - pmid:29191965 + pmid:22908190 - p(HGNC:CHRNA7) regulates act(a(CHEBI:"amyloid-beta")) + bp(GO:autophagy) decreases path(HBP:neurotoxicity) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) + bp(GO:autophagy) increases path(HBP:neurotoxicity) - pmid:19126755 + pmid:30145931 - p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") + bp(GO:autophagy) decreases path(HBP:neurotoxicity) - pmid:19126755 + pmid:22908190 - act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) + bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") - pmid:19126755 + pmid:23746257 - p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) + bp(GO:autophagy) increases bp(GO:"protein catabolic process") - pmid:19293145 + pmid:23746257 - p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) + bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) increases a(CHEBI:nicotine) + bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") - pmid:19126755 + pmid:18930136 - p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") + bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") + bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) + bp(GO:autophagy) increases deg(a(MESH:Proteins)) - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) + bp(GO:autophagy) regulates bp(GO:"metabolic process") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") + bp(GO:autophagy) association bp(GO:"antigen processing and presentation") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) + bp(GO:autophagy) decreases bp(MESH:Microbiota) - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) + bp(GO:autophagy) regulates bp(GO:"cell death") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) + bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium")) + bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) + bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) - - - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) + bp(GO:autophagy) increases a(HBP:"alpha-synuclein aggregates") - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") + bp(GO:autophagy) increases a(HBP:"alpha-synuclein oligomers") - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") + bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") + bp(GO:autophagy) decreases path(HBP:Neurodegeneration) - pmid:19293145 + pmid:18930136 - act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") + bp(GO:autophagy) decreases path(HBP:Neurodegeneration) - pmid:19293145 + pmid:18930136 - p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) + bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - - - - - - - - - - - pmid:17009926 + pmid:18930136 - p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") + bp(GO:autophagy) increases deg(p(HGNC:APP)) - pmid:22040696 + pmid:26195256 - p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") + bp(GO:autophagy) decreases p(HGNC:APP) - pmid:17009926 + pmid:18930136 - p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) + bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:17009926 + pmid:18930136 - act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") + bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:17009926 + pmid:28803412 - p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates") + bp(GO:autophagy) increases a(HBP:HBP00093) - pmid:17009926 + pmid:30145931 - p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262))) - pmid:26813123 + pmid:30145931 - p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356))) - pmid:26088141 + pmid:30116051 - p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly") + bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) - - - pmid:26088141 + pmid:30116051 - p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) + bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) - pmid:26088141 + pmid:24027553 - p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + bp(GO:autophagy) association p(HGNC:NPEPPS) - pmid:26088141 + pmid:23702978 - p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) + bp(GO:autophagy) regulates bp(GO:"apoptotic process") - pmid:18986241 + pmid:23702978 - p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) + bp(GO:autophagy) regulates complex(GO:"inflammasome complex") - pmid:18986241 + pmid:23702978 - p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) - - - + + + pmid:23702978 + + bp(GO:autophagy) decreases sec(p(HGNC:IL1B)) + - pmid:19721446 + pmid:27288790 - p(HGNC:CHRNA7) association a(MESH:Hippocampus) + a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB)) - pmid:19721446 + pmid:27288790 - p(HGNC:CHRNA7) association bp(GO:memory) + a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK)) - pmid:19721446 + pmid:27288790 - act(p(HGNC:CHRNA7)) decreases bp(GO:memory) + a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(Ph)) - pmid:19721446 + pmid:14556719 - p(HGNC:CHRNA7) association bp(GO:learning) + a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") - pmid:19721446 + pmid:23531502 - p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) + act(a(CHEBI:"hydrogen peroxide")) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") - pmid:19721446 + pmid:23722080 - act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) + a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") - pmid:19721446 + pmid:23722080 - p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") + a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) - pmid:19721446 + pmid:27288790 - p(HGNC:CHRNA7) association a(CHEBI:clozapine) + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:24561250 - p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:27314526 - p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:27314526 - p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") + p(HGNC:IL18) association path(MESH:"Alzheimer Disease") - - - pmid:22040696 + pmid:27288790 - p(HGNC:CHRNA7) association p(HGNC:BDNF) + p(HGNC:IL18) increases act(p(FPLX:NFkappaB)) - pmid:22040696 + pmid:24561250 - tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) + p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") - - - - - - - pmid:22040696 + pmid:24561250 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) + p(HGNC:IL18) increases bp(GO:"inflammatory response") - pmid:22040696 + pmid:27314526 - p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") + p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) - pmid:22040696 + pmid:27314526 - p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") + p(HGNC:IL18) increases bp(GO:"microglial cell activation") - pmid:22040696 + pmid:27314526 - p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") + p(HGNC:IL18) increases bp(GO:"astrocyte activation") - pmid:28901280 + pmid:27314526 - p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") + p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") - pmid:28901280 + pmid:27314526 - p(HGNC:CHRNA7) regulates path(MESH:Inflammation) + p(HGNC:IL18) increases p(HGNC:GSK3B) - pmid:28901280 + pmid:27314526 - p(HGNC:CHRNA7) association path(MESH:Neoplasms) + p(HGNC:IL18) increases p(HGNC:CDK5) - pmid:28901280 + pmid:27288790 - p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") + p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28901280 + pmid:27288790 - p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") + p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pmid:26304819 - p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") + p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:29191965 + pmid:21718217 - p(HGNC:CHRNA7) regulates act(a(GO:synapse)) + p(HGNC:TGFB1) decreases a(MESH:Macrophages) - pmid:29191965 + pmid:27288790 - p(HGNC:CHRNA7) association path(MESH:Tauopathies) + bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:14556719 - p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) - pmid:28901280 + pmid:14963027 - p(HGNC:CHRNA9) increases path(MESH:Neoplasms) + bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) - pmid:26813123 + pmid:27068745 - p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) - pmid:17009926 + pmid:27288790 - act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") + bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26813123 + pmid:27288790 - p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(Ph)) - - - pmid:19721446 + pmid:21214928 - p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) + bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:19293145 - p(HGNC:CHRNB2) association p(HGNC:DNM1) + bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:19126755 - p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") + bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:19721446 + pmid:19126755 - p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) + bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26813123 + pmid:19293145 - p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) - pmid:19126755 + pmid:19293145 - p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") + bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) - pmid:26813123 + pmid:19293145 - p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) - - - pmid:19721446 + pmid:19293145 - p(HGNC:CHRNB4) association act(a(CHEBI:nicotine)) + bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) - pmid:19721446 + pmid:19293145 - p(HGNC:CHRNB4) association path(MESH:Craving) + bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) - pmid:19721446 + pmid:24590577 - p(HGNC:CHRNB4) association path(MESH:Recurrence) + bp(GO:"MAPK cascade") increases p(HGNC:BACE1) - pmid:19126755 + pmid:27288790 - p(HGNC:TNF) increases bp(GO:"MAPK cascade") + bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB)) - pmid:19293145 + pmid:21214928 - p(HGNC:TNF) increases act(a(CHEBI:nicotine)) + bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:19126755 - p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) + bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) - pmid:23178521 + pmid:19293145 - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) + bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process") - pmid:23178521 + pmid:24590577 - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) + bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) - pmid:23178521 + pmid:24590577 - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) + bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing") - pmid:23178521 + pmid:27594586 - p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph)) + bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) - pmid:23178521 + pmid:27288790 - p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) + a(CHEBI:"SB-239063") decreases act(p(HGNC:MAPK14)) - pmid:23178521 + pmid:27288790 - p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) + a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK) - pmid:25331948 + pmid:27288790 - p(HGNC:TNF) increases p(HGNC:BACE1) + a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14)) - pmid:25331948 + pmid:27288790 - p(HGNC:TNF) increases p(HGNC:BACE1) + a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:25331948 + pmid:27288790 - p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") + a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory) - pmid:25331948 + pmid:27288790 - p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process") - pmid:19126755 + pmid:27288790 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) + a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation") - pmid:19126755 + pmid:25681682 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) - pmid:19126755 + pmid:24183963 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) - pmid:19126755 + pmid:24183963 - p(HBP:"alpha-4 beta-2 nAChR") increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:26095350 - act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") + a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) - pmid:19126755 + pmid:26095350 - act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) + a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) - pmid:19126755 + pmid:22798221 - act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) + a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin)) - pmid:19126755 + pmid:22798221 - p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) + a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin)) - pmid:26472524 + pmid:8063802 - act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") + a(CHEBI:"advanced glycation end-product") decreases act(p(HGNC:MAPT)) - pmid:19126755 + pmid:8063802 - p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") + a(CHEBI:"advanced glycation end-product") increases bp(GO:"neurofibrillary tangle assembly") - pmid:19126755 + pmid:18930136 - p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") + bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") - pmid:26472524 + pmid:18930136 - p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) + bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) - pmid:19126755 + pmid:18930136 - a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") + bp(GO:"cellular protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) - pmid:19126755 + pmid:25036637 - bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) + bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) - pmid:19126755 + pmid:25036637 - a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) + bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) - pmid:19126755 + pmid:25036637 - a(MESH:Neurons) decreases r(HGNC:CHRNA3) + bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) - pmid:19126755 + pmid:27671637 - a(MESH:Neurons) increases r(HGNC:CHRNA4) + bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) - pmid:19126755 + pmid:27288790 - a(MESH:Neurons) association p(HGNC:CHRNA7) + a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product") - pmid:19126755 + pmid:27288790 - a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") + a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:27288790 - a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) + a(HBP:GLAP) isA a(CHEBI:"advanced glycation end-product") - pmid:21482353 + pmid:27288790 - a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + a(HBP:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:28901280 - - a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") - + - pmid:27671637 + pmid:27288790 - act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1) - pmid:29238289 + pmid:27288790 - act(a(MESH:Neurons)) increases p(HGNC:MAPT) + complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) - pmid:29238289 + pmid:27288790 - act(a(MESH:Neurons)) increases p(HGNC:MAPT) + act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade") - pmid:29238289 + pmid:26195256 - a(MESH:Neurons) causesNoChange p(HGNC:MAPT) + p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta")) - pmid:27796283 + pmid:29626319 - act(a(MESH:Neurons)) increases p(HGNC:CAMKV) + p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:27087442 + pmid:18494933 - act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1) + act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK) - pmid:27087442 + pmid:25681682 - act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b)) + p(HGNC:AGER) negativeCorrelation bp(GO:aging) - pmid:27087442 + pmid:25681682 - act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5) + p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") - pmid:19126755 + pmid:24183963 - path(HBP:neurotoxicity) association a(CHEBI:nicotine) + act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) - pmid:19293145 + pmid:18494933 - path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers") + act(p(HGNC:AGER)) increases p(HGNC:MAPK8, pmod(Ph)) + + + + - pmid:19293145 + pmid:27288790 - path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + complex(a(HBP:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1) - pmid:22908190 + pmid:27288790 - path(HBP:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + complex(a(HBP:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) - pmid:24027553 + pmid:27288790 - path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates") + p(HGNC:GSK3B) increases p(HGNC:BACE1) - - - - - - - pmid:19126755 + pmid:30444369 - complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) - - - - - pmid:19126755 + pmid:12428809 - complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) - pmid:21787755 + pmid:29758300 - a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) - pmid:21787755 + pmid:21882945 - a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) + act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:29191965 - act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - - - - - pmid:19126755 + pmid:29311797 - complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:12551948 - a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:24183963 - a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:18494933 - a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels")) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19721446 + pmid:29121589 - a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:19721446 + pmid:10998059 - a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19721446 + pmid:27314526 - a(MESH:Conotoxins) decreases path(MESH:Pain) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19126755 + pmid:22122372 - p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) + p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:19126755 + pmid:22122372 - a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") + p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) - - - - - pmid:19126755 + pmid:22122372 - complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - a(TAXONOMY:92736) increases a(CHEBI:epibatidine) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:19293145 + pmid:25331948 - a(CHEBI:epibatidine) causesNoChange bp(GO:memory) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:19293145 + pmid:14612456 - a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:19293145 + pmid:17078951 - a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:19293145 + pmid:19459590 - a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:28132910 + pmid:29844403 - a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + act(p(HGNC:GSK3B)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - - - - - pmid:19126755 + DOI:10.4172/2168-975X.1000126 - complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - - - - - pmid:19126755 + pmid:25331948 - complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - - - - - pmid:19126755 + pmid:14612456 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:19293145 + pmid:17078951 - a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:19293145 + pmid:19459590 - a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:19293145 + DOI:10.4172/2168-975X.1000126 - a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:19293145 + pmid:17078951 - a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:25881725 + DOI:10.4172/2168-975X.1000126 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25881725 + pmid:25331948 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25881725 + pmid:14612456 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25881725 + pmid:17078951 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25881725 + pmid:21734277 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) + act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) + act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) + act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph)) - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") + act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing") - pmid:25881725 + pmid:24653673 - a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) - pmid:19721446 + pmid:24653673 - a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) + act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") - - - - - pmid:19126755 + pmid:24653673 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) + act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") - - - - - pmid:19126755 + pmid:24653673 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) + act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:19126755 + pmid:24653673 - r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") + act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) - pmid:19126755 + pmid:24653673 - r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") + act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21787755 + pmid:24653673 - r(HGNC:CHRNB4) association r(HGNC:CHRNA4) + act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) - pmid:21787755 + pmid:24653673 - r(HGNC:CHRNA4) association r(HGNC:CHRNB4) + act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) - pmid:21787755 + pmid:24653673 - r(HGNC:CHRNA6) association path(MESH:Reward) + act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) - pmid:21787755 + pmid:24653673 - r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") + act(p(HGNC:GSK3B)) increases p(HGNC:SET) - pmid:21787755 + pmid:12428809 - r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:19126755 + pmid:18494933 - a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:19126755 + pmid:12428809 - path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) + p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) - pmid:24561250 + pmid:12428809 - path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - pmid:24561250 + pmid:12428809 - path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") + p(HGNC:GSK3B) increases a(MESH:Axons) - pmid:19126755 + pmid:12428809 - a(MESH:Adult) decreases r(HGNC:CHRNA3) + p(HGNC:GSK3B) association bp(GO:"axonal transport") - pmid:19126755 + pmid:21882945 - a(MESH:Adult) increases r(HGNC:CHRNA4) + p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) @@ -34737,424 +35811,417 @@

Statements

- - - pmid:19126755 + pmid:30640040 - bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:GSK3B) association a(PUBCHEM:71295844) - pmid:22040696 + pmid:29191965 - bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") + p(HGNC:GSK3B) association path(MESH:Tauopathies) - pmid:22040696 + pmid:11812770 - bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244")) - pmid:19126755 + pmid:11812770 - r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") + p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) - pmid:19126755 + pmid:14612456 - act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:19126755 + pmid:17078951 - act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:19126755 + pmid:21734277 - p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:18986241 + pmid:18494933 - p(HGNC:NGF) isA a(MESH:D009414) + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") - pmid:18986241 + pmid:12551948 - act(p(HGNC:NGF)) increases bp(GO:"GO:0000165") + p(HGNC:GSK3B) association p(HGNC:YWHAZ) - pmid:18986241 + pmid:12551948 - p(HGNC:NGF) causesNoChange path(MESH:D003929) + p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) - pmid:18986241 + pmid:29121589 - p(HGNC:NGF) causesNoChange path(MESH:D016263) + p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph)) - pmid:18986241 + pmid:29121589 - p(HGNC:NGF) causesNoChange path(MESH:D000544) + p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) - pmid:18986241 + pmid:24355211 - p(HGNC:NGF) association bp(GO:"GO:0060384") + p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) - pmid:18986241 + pmid:29121589 - p(HGNC:NGF) association bp(GO:"GO:0007269") + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:DPYSL2, pmod(Ph)) - pmid:18986241 + pmid:7514173 - p(HGNC:NGF) association bp(GO:"GO:0048485") + act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph)) - pmid:18986241 + pmid:7514173 - p(HGNC:NGF) association path(MESH:D002100) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph)) - pmid:18986241 + pmid:7514173 - p(HGNC:NGF) association path(MESH:D006930) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph)) - pmid:18986241 + pmid:7514173 - p(HGNC:NGF) decreases path(MESH:D060825) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph)) - pmid:24686445 + pmid:7514173 - p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph)) - pmid:24686445 + pmid:17078951 - p(HGNC:NGF) increases act(p(HGNC:KAT2B)) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - - - - - pmid:19126755 + pmid:17078951 - act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:18494933 + pmid:19459590 - p(HGNC:JUN) partOf p(FPLX:AP1) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:19126755 + pmid:21734277 - act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - - - - - pmid:19126755 + pmid:17078951 - composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217)) - pmid:19126755 + pmid:17078951 - p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:19126755 + pmid:17078951 - p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) + act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212)) - - - - - pmid:19126755 + pmid:9089387 - complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) - - - pmid:19126755 + pmid:9089387 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) + p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26") - - - pmid:25514383 + pmid:26501932 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") + p(HGNC:GSK3B) partOf a(HBP:"GVD bodies") - pmid:25514383 + pmid:25331948 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) + act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1") - - - pmid:19126755 + pmid:25331948 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation act(p(HGNC:SYK)) - - - pmid:19126755 + pmid:28176663 - a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") - pmid:19126755 + pmid:28176663 - a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) + act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") - pmid:19126755 + pmid:28176663 - a(MESH:Muscles) increases r(HGNC:CHRNA1) + act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") - pmid:19126755 + pmid:19459590 - a(MESH:Muscles) increases r(HGNC:CHRNB1) + act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, AT8") - pmid:19126755 + pmid:24355211 - a(MESH:Muscles) increases r(HGNC:CHRND) + p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") - pmid:19126755 + pmid:24355211 - a(MESH:Muscles) increases r(HGNC:CHRNG) + p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) - + + + pmid:24355211 + + p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) + - + + + pmid:24355211 + + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + - pmid:19126755 + pmid:24355211 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) - pmid:19126755 + pmid:25546293 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) - pmid:23038257 + pmid:25546293 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) - pmid:26813123 + pmid:25546293 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) + act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) - pmid:19126755 + pmid:27288790 - act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") + p(HGNC:GSK3A) causesNoChange p(HGNC:BACE1) - pmid:26813123 + pmid:30640040 - p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:GSK3A) association a(PUBCHEM:71295844) - + + + pmid:22817713 + + p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") + @@ -35164,23 +36231,28 @@

Statements

- pmid:19126755 + pmid:27288790 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) + composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1) - pmid:19126755 + pmid:27288790 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) + p(HGNC:UCHL1) decreases p(HGNC:BACE1) - + + + pmid:27288790 + + act(p(HGNC:UCHL1)) decreases p(HGNC:BACE1) + @@ -35190,662 +36262,647 @@

Statements

- pmid:19126755 + pmid:14556719 - bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) + p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") - pmid:19126755 + pmid:14556719 - bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) + p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) - pmid:17009926 + pmid:14556719 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") + p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") - pmid:26472524 + pmid:14556719 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") + p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") - pmid:17009926 + pmid:14556719 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") + p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") - pmid:19126755 + pmid:22908190 - r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") - pmid:19126755 + pmid:22908190 - r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) + p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") - - - - - pmid:19126755 + pmid:22908190 - composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) + p(HGNC:UCHL1) increases act(a(GO:synapse)) - - - - - - - pmid:19126755 + pmid:22908190 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + p(HGNC:UCHL1) increases bp(GO:memory) - - - - - - - - - pmid:19126755 + pmid:27288790 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - - - - - - - pmid:19126755 + pmid:27288790 - composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + a(MESH:Lipopolysaccharides) increases p(HGNC:TNF) - - - - - - - - - pmid:19126755 + pmid:27288790 - a(MESH:Oocytes) association composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + a(MESH:Lipopolysaccharides) increases sec(p(HGNC:TNF)) - - - - - - - pmid:19126755 + pmid:27288790 - composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) + a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B) - pmid:19126755 + pmid:27288790 - a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR") + a(MESH:Lipopolysaccharides) increases sec(p(HGNC:IL1B)) - pmid:19126755 + pmid:27288790 - a(MESH:Hippocampus) increases p(HGNC:CHRNA7) + m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:ALOX15) - pmid:19721446 + pmid:27288790 - a(MESH:Hippocampus) association p(HGNC:CHRNA7) + m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:VDR) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:cognition) + m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1)) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:learning) + m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin)) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:learning) + m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin)) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:memory) + m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:memory) + m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:PPP1CA)) - pmid:19721446 + pmid:25001178 - a(MESH:Hippocampus) association bp(GO:memory) + m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:DUSP6)) - pmid:24511233 + pmid:25001178 - a(MESH:Hippocampus) association p(HGNC:CHRM4) + m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:BCL2L2)) - pmid:24590577 + pmid:27288790 - a(MESH:Hippocampus) association p(HGNC:CHRM1) + m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15) - pmid:24590577 + pmid:27288790 - a(MESH:Hippocampus) association p(HGNC:CHRM2) + m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR) - pmid:24590577 + pmid:27288790 - a(MESH:Hippocampus) association p(HGNC:CHRM3) + m(MIRBASE:"hsa-mir-146a") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26390242 + pmid:27288790 - a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate) + m(MIRBASE:"hsa-mir-146a") association r(HGNC:IRAK1) - pmid:19126755 + pmid:27288790 - a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-2 nAChR") + m(MIRBASE:"hsa-mir-146a") association bp(GO:"immune response") - pmid:19126755 + pmid:27288790 - a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR") + m(MIRBASE:"hsa-mir-146a") increases path(HP:Neurodegeneration) - - - - - pmid:19126755 + pmid:27288790 - composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) + m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:27288790 - g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) + m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Multiple Sclerosis") - pmid:19126755 + pmid:27288790 - g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") + r(HGNC:IRAK1) association m(MIRBASE:"hsa-mir-146a") - - - pmid:19126755 + pmid:27288790 - a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:"hsa-mir-155") - pmid:19126755 + pmid:27288790 - a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + r(HGNC:"BACE1-AS") regulates r(HGNC:BACE1) - - - - - pmid:19126755 + pmid:27288790 - composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + r(HGNC:"BACE1-AS") decreases deg(r(HGNC:BACE1)) - - - - - + + + pmid:27288790 + + r(HGNC:"BACE1-AS") regulates p(HGNC:BACE1) + - pmid:25514383 + pmid:27288790 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR") + r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19721446 + pmid:27288790 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB)) - pmid:19126755 + pmid:27288790 - p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:NOS2) - - - pmid:19126755 + pmid:27288790 - a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly") + a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:PTGS2) - pmid:19126755 + pmid:27288790 - a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Morphine) decreases act(p(FPLX:NFkappaB)) - pmid:19126755 + pmid:27288790 - a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + a(MESH:Morphine) increases p(FPLX:IKB) - pmid:19126755 + pmid:27288790 - bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) + a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19126755 + pmid:27288790 - bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) + a(PUBCHEM:439378) decreases p(FPLX:ERK) - pmid:19126755 + pmid:27288790 - a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + a(PUBCHEM:439378) decreases p(HGNC:MAPK14) - pmid:29626319 + pmid:27288790 - a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) + a(PUBCHEM:439378) decreases p(FPLX:NFkappaB) - pmid:29626319 + pmid:27288790 - a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) + a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) - pmid:29626319 + pmid:27288790 - a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) + a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB)) - + + + pmid:27288790 + + a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) + - pmid:21787755 + pmid:27288790 - a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB)) - - - + + + pmid:27288790 + + a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") + - + + + pmid:27288790 + + a(CHEBI:naproxen) decreases r(HGNC:BACE1) + - + + + pmid:27288790 + + a(CHEBI:naproxen) decreases a(CHEBI:"amyloid-beta") + - pmid:19126755 + pmid:27288790 - composite(a(CHEBI:nicotine), g(HGNC:CHRNA4), g(HGNC:CHRNA6), g(HGNC:CHRNB2), g(HGNC:CHRNB3)) increases composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) + a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB)) - + + + pmid:27288790 + + a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process") + - + + + pmid:27288790 + + a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") + - pmid:19126755 + pmid:27288790 - act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) + a(CHEBI:nicorandil) decreases p(HBP:APP695) - pmid:19293145 + pmid:27288790 - a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") + a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:25514383 + pmid:27288790 - a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") + a(PUBCHEM:6440944) decreases act(p(FPLX:ERK)) - pmid:25514383 + pmid:27288790 - act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") + a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(Ph)) - pmid:25514383 + pmid:27288790 - act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction") + a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(Ph)) - pmid:25514383 + pmid:27288790 - act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") + a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pmid:27288790 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) + a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21482353 + pmid:27288790 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") + a(PUBCHEM:6440944) decreases p(HGNC:APP) - pmid:21482353 + pmid:27288790 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") + a(PUBCHEM:6440944) decreases a(CHEBI:"amyloid-beta") - pmid:19126755 + pmid:27288790 - sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane") + a(PUBCHEM:6440944) decreases sec(a(CHEBI:"amyloid-beta")) + + + + + + - pmid:21482353 + pmid:25652642 - a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) + complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) - pmid:21482353 + pmid:25652642 - a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) + bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) - pmid:21482353 + pmid:17009926 - a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:19126755 + pmid:26813123 - bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) + bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) - pmid:19126755 + pmid:26813123 - bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) + bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) @@ -35854,25 +36911,25 @@

Statements

pmid:26813123 - bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) - pmid:26813123 + pmid:25652642 - bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) - pmid:26813123 + pmid:24511233 - bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) + bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) @@ -35881,7 +36938,7 @@

Statements

pmid:26813123 - bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) + bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) @@ -35890,666 +36947,664 @@

Statements

pmid:26813123 - bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) + bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration) - pmid:28901280 + pmid:30106381 - bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") + bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP) - pmid:19126755 + pmid:30106381 - act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression") + bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation a(PUBCHEM:9832404) - pmid:19126755 + pmid:25652642 - act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") + bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:19126755 + pmid:25652642 - act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") + bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) - - - pmid:27550730 + pmid:19126755 - act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) + bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:19126755 + pmid:22040696 - act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") + bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") - pmid:19126755 + pmid:22040696 - act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript)) + bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) - pmid:19126755 + pmid:25652642 - complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) + a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex")) - pmid:14556719 + pmid:25652642 - bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") + a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:19126755 + pmid:29196815 - p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine)) + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:28420982 - p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine)) + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:22817713 - bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine)) + a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") - pmid:28445721 + pmid:24653673 - bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) + a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(Me, Tyr, 307)) - pmid:19126755 + pmid:29758300 - a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") + a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) - pmid:21787755 + pmid:22908190 - sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) + a(GO:"neurofibrillary tangle") association a(HBP:"paired helical filaments") - pmid:21787755 + pmid:22908190 - sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) + a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) - pmid:27075649 + pmid:22908190 - a(CHEBI:dopamine) increases a(HBP:HBP00093) + a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:27075649 + pmid:22908190 - a(CHEBI:dopamine) increases a(HBP:HBP00093) + a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) - pmid:19126755 + pmid:22908190 - a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") + a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") - pmid:19293145 + pmid:22908190 - act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity) + a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:17009926 + pmid:18930136 - sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation") + a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) - pmid:16273023 + pmid:27671637 - a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") + a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:16273023 + pmid:30126037 - a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) + a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) - pmid:21482353 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") + a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") - pmid:19721446 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) + a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") - pmid:19721446 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) - pmid:19721446 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) - pmid:19721446 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) - pmid:19721446 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) + a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) - pmid:28901280 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) + a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") - pmid:14556719 + pmid:30126037 - a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) + a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") - pmid:19126755 + pmid:30126037 - a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") - pmid:19126755 + pmid:30126037 - a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") - pmid:28901280 + pmid:30126037 - a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") - pmid:28901280 + pmid:30126037 - a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) + a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) - pmid:19126755 + pmid:30126037 - a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) - pmid:28901280 + pmid:30126037 - a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) + a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) - pmid:28901280 + pmid:30126037 - a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") + a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) - pmid:24027553 + pmid:30126037 - a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin)) + a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) - pmid:19126755 + pmid:30126037 - p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) + a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) - pmid:19293145 + pmid:30126037 - p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) + a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) - pmid:17009926 + pmid:30126037 - act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) - pmid:26813123 + pmid:30126037 - p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) - pmid:21482353 + pmid:30126037 - p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) - pmid:23038257 + pmid:30126037 - p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) - pmid:17009926 + pmid:30126037 - act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) - pmid:26813123 + pmid:30126037 - p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) - pmid:26813123 + pmid:30126037 - p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) - pmid:11230871 + pmid:30126037 - act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) - pmid:26813123 + pmid:30126037 - p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta") + a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) - pmid:25514383 + pmid:30126037 - act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") + a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") - pmid:21482353 + pmid:30126037 - act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") + a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") - pmid:18986241 + pmid:30126037 - p(HGNC:ACHE) association path(MESH:D058225) + a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") - pmid:18986241 + pmid:30126037 - p(HGNC:ACHE) increases bp(GO:"GO:1990000") + a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") - pmid:19126755 + pmid:26751493 - a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) + a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) - pmid:19293145 + pmid:26751493 - act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta")) + a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) - pmid:19293145 + pmid:26751493 - act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) + a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) - pmid:26813123 + pmid:23531502 - a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) + a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein)) - pmid:26813123 + pmid:12578227 - a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) - pmid:19126755 + pmid:12578227 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) - pmid:19126755 + pmid:9099822 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2)) - pmid:19126755 + pmid:11089576 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) - pmid:18986241 + pmid:11738469 - a(CHEBI:physostigmine) decreases path(MESH:D000544) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) - pmid:19126755 + pmid:8985134 - a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) - pmid:19126755 + pmid:18239272 - a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) + a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8") - pmid:17009926 + pmid:26751493 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine)) + a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") - pmid:17009926 + pmid:26118667 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25") - pmid:17009926 + pmid:22002427 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:17009926 + pmid:22002427 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) - pmid:17009926 + pmid:25652642 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)")) + path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:17009926 + pmid:25652642 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid")) + path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") - pmid:17009926 + pmid:25652642 - a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) + path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") - pmid:19126755 + pmid:29196815 - a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") @@ -36558,97 +37613,97 @@

Statements

pmid:19126755 - a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:19293145 - a(HBP:"FK1 antibody") decreases a(CHEBI:codeine) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:19293145 - a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) + path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:19293145 - a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:24511233 - path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:24590577 - path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") + path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:25514383 - path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24511233 + pmid:22817713 - path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24511233 + pmid:19293145 - path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") + path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) - pmid:24511233 + pmid:19293145 - path(MESH:Schizophrenia) association path(MESH:Hallucinations) + path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) - pmid:19721446 + pmid:19293145 - path(MESH:Schizophrenia) association path(MESH:Hallucinations) + path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) @@ -36657,16 +37712,16 @@

Statements

pmid:24511233 - path(MESH:Schizophrenia) association path(MESH:Delusions) + path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") - pmid:19721446 + pmid:24511233 - path(MESH:Schizophrenia) association path(MESH:Delusions) + path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation) @@ -36675,277 +37730,274 @@

Statements

pmid:24511233 - path(MESH:Schizophrenia) association bp(GO:cognition) + path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") - pmid:19721446 + pmid:24590577 - path(MESH:Schizophrenia) association bp(GO:cognition) + path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") - pmid:24511233 + pmid:25514383 - path(MESH:Schizophrenia) association bp(GO:behavior) + path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) - pmid:24511233 + pmid:29758300 - path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:24511233 + pmid:14556719 - path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") - pmid:24511233 + pmid:24027553 - path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAP1LC3A) - pmid:24511233 + pmid:28420982 - path(MESH:Schizophrenia) association path(MESH:Attention) + path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) - pmid:24511233 + pmid:23531502 - path(MESH:Schizophrenia) association path(MESH:"Executive Function") + path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein)) - pmid:24511233 + pmid:18562203 - path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - pmid:24511233 + pmid:26400044 - path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") + path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) - pmid:17009926 + pmid:18239272 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8") - pmid:17009926 + pmid:28877763 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + path(MESH:"Plaque, Amyloid") positiveCorrelation p(MGI:Syk, pmod(Ph)) - pmid:21482353 + pmid:28877763 - path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) - pmid:11230871 + pmid:24401760 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) - pmid:21482353 + pmid:24401760 - path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) + path(MESH:"Plaque, Amyloid") partOf a(HBP:"dystrophic neurite") - pmid:21482353 + pmid:25652642 - path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") + act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") - pmid:21482353 + pmid:19293145 - path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) + p(HGNC:APOE) association bp(GO:"lipid metabolic process") - pmid:21482353 + pmid:19293145 - path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) + p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:21482353 + pmid:21718217 - path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") - pmid:21482353 + pmid:21718217 - path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:21482353 + pmid:21718217 - path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) + act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:11230871 + pmid:26195256 - path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR") + p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") - pmid:11230871 + pmid:26195256 - path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR") + p(HGNC:APOE) decreases act(a(CHEBI:"amyloid-beta")) - pmid:19721446 + pmid:26195256 - path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") + p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:30106381 - path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) + p(HGNC:APOE) association a(PUBCHEM:9832404) - pmid:22040696 + pmid:30106381 - path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) + p(HGNC:APOE) increases path(MESH:"Alzheimer Disease") - - - pmid:22040696 - - path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) - + + + - pmid:19126755 + pmid:25652642 - path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:TNF)) - pmid:19126755 + pmid:25652642 - path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:NGF)) - pmid:19126755 + pmid:25652642 - path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF)) - pmid:19126755 + pmid:25652642 - path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) + a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) @@ -36954,736 +38006,723 @@

Statements

pmid:19126755 - path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) + act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") - pmid:29758300 + pmid:19126755 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) - pmid:18930136 + pmid:19126755 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18930136 + pmid:18986241 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") + p(HGNC:NGF) isA a(MESH:D009414) - pmid:24027553 + pmid:18986241 - path(HBP:Neurodegeneration) association p(MGI:Mapt, var("p.P301L")) + act(p(HGNC:NGF)) increases bp(GO:"GO:0000165") - pmid:17403556 + pmid:18986241 - path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:NGF) causesNoChange path(MESH:D003929) - pmid:26631930 + pmid:18986241 - path(HBP:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + p(HGNC:NGF) causesNoChange path(MESH:D016263) - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:NGF) causesNoChange path(MESH:D000544) - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HGNC:NGF) association bp(GO:"GO:0060384") - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + p(HGNC:NGF) association bp(GO:"GO:0007269") - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) + p(HGNC:NGF) association bp(GO:"GO:0048485") - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) + p(HGNC:NGF) association path(MESH:D002100) - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + p(HGNC:NGF) association path(MESH:D006930) - pmid:19126755 + pmid:18986241 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + p(HGNC:NGF) decreases path(MESH:D060825) - pmid:19126755 + pmid:24686445 - a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) + p(HGNC:NGF) increases p(FPLX:ERK, pmod(Ph)) - pmid:19126755 + pmid:24686445 - a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") + p(HGNC:NGF) increases act(p(HGNC:KAT2B)) - pmid:19126755 + pmid:25652642 - a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") + p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) - pmid:19126755 + pmid:25652642 - a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") + p(HGNC:GRM5) increases act(p(HGNC:SOD2)) - pmid:19126755 + pmid:25652642 - a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) + p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) - pmid:19126755 + pmid:24653673 - a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") + p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") - - - pmid:23383175 - - a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) - + - pmid:23383175 + pmid:25652642 - a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") + complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta")) - pmid:28803412 + pmid:14556719 - a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) + bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) - pmid:30108137 + pmid:23746257 - a(MESH:Astrocytes) increases p(MGI:Tfeb) + bp(GO:"cell death") negativeCorrelation bp(HBP:Proteostasis) - pmid:30108137 + pmid:18930136 - act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils") + bp(GO:"cell death") negativeCorrelation a(GO:aggresome) - pmid:26195256 + pmid:24561250 - act(a(MESH:Astrocytes)) decreases p(HGNC:APP) + bp(GO:"cell death") increases sec(a(CHEBI:ATP)) - - - pmid:26195256 - - a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) - + - pmid:18562203 + pmid:25652642 - act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pmid:19293145 - a(MESH:Astrocytes) increases p(HGNC:NLRP3) + a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) - pmid:27314526 + pmid:26813123 - a(MESH:Astrocytes) increases p(HGNC:TLR4) + act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) - pmid:27314526 + pmid:26813123 - a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) + a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) - pmid:19126755 + pmid:26813123 - a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid") + a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) - pmid:19126755 + pmid:26813123 - a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") + a(MESH:"Cholinergic Neurons") increases bp(GO:memory) - pmid:19126755 + pmid:26813123 - bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") + a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") - pmid:19126755 + pmid:26813123 - act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid") + a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) - pmid:19126755 + pmid:26813123 - a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") + a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) - pmid:19126755 + pmid:26813123 - a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine") + a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) - pmid:19126755 + pmid:26813123 - a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") + a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA) + a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA) + a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex")) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:WISP1) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") - pmid:19623258 + pmid:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) + a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) - pmid:19623258 + pmid:28901280 - a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) + a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) - - - pmid:19623258 - - a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) - - - pmid:19623258 + pmid:19293145 - a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) + tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") - pmid:19623258 + pmid:25652642 - a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) + bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) - pmid:19126755 + pmid:25652642 - act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) + bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) - pmid:19126755 + pmid:25652642 - p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) + p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia)) + + - pmid:19293145 + pmid:25652642 - p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") + a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") + a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25881725 + pmid:25652642 - act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") + m(HGNC:"MIR9-1") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) decreases p(MGI:Syp) + m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) decreases p(MGI:Map2) + m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) increases p(MGI:Map2) + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta") + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta") + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) increases bp(GO:cognition) + m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") + m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:25652642 - p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") + m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27522251 + pmid:25652642 - p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") + p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) + + - pmid:27522251 + pmid:25652642 - p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") + p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) - pmid:27522251 + pmid:30126037 - p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") + p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") - pmid:27522251 + pmid:30126037 - p(MGI:Chrna7) association bp(GO:aging) + p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:27522251 + pmid:30126037 - p(MGI:Chrna7) increases a(HBP:HBP00022) + p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:25881725 + pmid:30126037 - act(p(MGI:Chrna7)) increases bp(GO:learning) + p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) - pmid:25881725 + pmid:30126037 - p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") - pmid:28901280 + pmid:30444369 - p(MGI:Chrna7) association act(a(MESH:Epithelium)) + a(CHEBI:tacrine) increases bp(GO:cognition) - pmid:21482353 + pmid:30444369 - a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") + a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) - pmid:19126755 + pmid:19293145 - bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) + a(CHEBI:tacrine) increases p(HGNC:BCL2) - pmid:19126755 + pmid:19293145 - bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) + act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) - pmid:24760868 + pmid:24511233 - bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) + a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:28420982 + pmid:11230871 - bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) + a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) - pmid:28420982 + pmid:11230871 - bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") + a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) - pmid:19126755 + pmid:11230871 - a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) + a(CHEBI:tacrine) increases p(FPLX:CHRN) - pmid:19126755 + pmid:30444369 - a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) + a(CHEBI:donepezil) increases bp(GO:cognition) - pmid:19126755 + pmid:26813123 - a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:donepezil) increases bp(GO:cognition) - pmid:19126755 + pmid:30444369 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) @@ -37692,173 +38731,169 @@

Statements

pmid:19126755 - a(CHEBI:anandamide) association p(HGNC:CNR1) + a(CHEBI:donepezil) decreases p(HGNC:ACHE) - pmid:19126755 + pmid:11230871 - a(CHEBI:anandamide) association p(HGNC:CNR2) + a(CHEBI:donepezil) increases act(p(HGNC:ACHE)) - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") + a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") + a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") + a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") + a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) + a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19126755 + pmid:19293145 - a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") + a(CHEBI:donepezil) increases p(HGNC:CHRNA4) - pmid:19126755 + pmid:19293145 - p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:donepezil) increases p(HGNC:CHRNA7) - - - - pmid:19293145 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) + a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) - pmid:17009926 + pmid:19293145 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") + a(CHEBI:donepezil) increases p(HGNC:BCL2) - pmid:25514383 + pmid:24511233 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") + a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:19126755 + pmid:18986241 - p(HGNC:CNR1) association a(CHEBI:anandamide) + a(CHEBI:donepezil) increases act(a(MESH:D005625)) - pmid:19126755 + pmid:29626319 - p(HGNC:CNR2) association a(CHEBI:anandamide) + a(CHEBI:donepezil) increases p(HGNC:ABCB1) - pmid:19126755 + pmid:29626319 - a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) + a(CHEBI:donepezil) increases p(HGNC:LRP1) - pmid:19126755 + pmid:29626319 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) + a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta") - pmid:19126755 + pmid:30444369 - a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) + a(CHEBI:rivastigmine) increases bp(GO:cognition) - pmid:19126755 + pmid:30444369 - a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) @@ -37867,115 +38902,115 @@

Statements

pmid:19126755 - a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) - pmid:19126755 + pmid:11230871 - a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") + a(CHEBI:rivastigmine) increases act(p(HGNC:ACHE)) - pmid:19126755 + pmid:19293145 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) + a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:19126755 + pmid:19293145 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:26813123 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:19293145 - path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) + a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity) - pmid:17009926 + pmid:19293145 - bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) + a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:26813123 + pmid:24511233 - bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) + a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:26813123 + pmid:29626319 - bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) + a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) - pmid:26813123 + pmid:29626319 - bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) + a(CHEBI:rivastigmine) increases p(HGNC:LRP1) - pmid:24590577 + pmid:29626319 - bp(GO:"neuron differentiation") association p(HGNC:CHRM1) + a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta") - pmid:28884684 + pmid:30444369 - bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) + a(CHEBI:memantine) increases bp(GO:cognition) - pmid:19293145 + pmid:30444369 - p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) + a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) @@ -37984,7 +39019,7 @@

Statements

pmid:19293145 - act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) + a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") @@ -37993,79 +39028,79 @@

Statements

pmid:19293145 - act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) + a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:23722080 - p(FPLX:PI3K) increases act(a(MESH:Synapses)) + a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:26813123 - act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") + a(CHEBI:memantine) decreases a(HBP:Excitotoxicity) - pmid:19293145 + pmid:16273023 - p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) + a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:22040696 + pmid:16273023 - act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") + a(CHEBI:memantine) causesNoChange bp(MESH:D009435) - pmid:30116051 + pmid:23722080 - act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") + a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) - pmid:26813123 + pmid:23722080 - p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph)) + a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) - pmid:24653673 + pmid:23722080 - p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(Ph, Ser)) + a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") - pmid:24653673 + pmid:19126755 - p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(Ph, Ser)) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) @@ -38074,2285 +39109,2289 @@

Statements

- pmid:22908190 + pmid:24511233 - act(p(FPLX:PKA)) increases p(HGNC:UCHL1) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") - pmid:30116051 + pmid:24511233 - act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120)) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) - pmid:25331948 + pmid:16273023 - p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) - pmid:25331948 + pmid:30444369 - p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - - - pmid:25331948 + pmid:29196815 - act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(Ph)) + g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:29191965 + pmid:26195256 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") - pmid:26631930 + pmid:30444369 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:APP, var("?")) increases p(HGNC:MAPT) - pmid:26631930 + pmid:30116051 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) - pmid:23001711 + pmid:30116051 - act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) - pmid:17493042 + pmid:30116051 - p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + g(HGNC:APP, var("?")) increases a(HBP:HBP00081) + + - pmid:17078951 + pmid:30444369 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") - pmid:17078951 + pmid:29758300 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + g(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") - pmid:17078951 + pmid:30444369 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + g(HBP:"APOE e4") decreases deg(p(HGNC:APP)) - pmid:17078951 + pmid:29758300 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217)) + g(HBP:"APOE e4") increases bp(GO:"cholesterol metabolic process") - pmid:17078951 + pmid:29758300 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + g(HBP:"APOE e4") regulates deg(a(CHEBI:"amyloid-beta")) - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + g(HBP:"APOE e4") increases act(a(CHEBI:"amyloid-beta")) - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + g(HBP:"APOE e4") regulates bp(GO:"cholesterol transport") - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212)) + g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) + g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) + g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis) - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) + g(HBP:"APOE e4") increases a(GO:endosome) - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) + g(HBP:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:17078951 + pmid:22908190 - p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) + g(HBP:"APOE e4") increases path(HBP:Neurodegeneration) - pmid:26692334 + pmid:22908190 - act(p(FPLX:PKA)) positiveCorrelation a(CHEBI:rolipram) + g(HBP:"APOE e4") increases bp(GO:"apoptotic process") - pmid:26692334 + pmid:30444369 - act(p(FPLX:PKA)) positiveCorrelation act(complex(GO:"proteasome complex")) + g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:19721446 + pmid:29196815 - act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) + g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:23001711 + pmid:30116051 - p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:26195256 - act(p(HGNC:STAT3)) association p(HGNC:JAK2) + g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:30116051 - act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine)) + g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) - - pmid:30116051 - p(HGNC:STAT3) decreases bp(GO:macroautophagy) + g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) - pmid:19126755 + pmid:30116051 - act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") + g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) + + - pmid:19126755 + pmid:30444369 - act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") + g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") - - - pmid:19293145 + pmid:29196815 - act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") + g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:28784767 + pmid:26195256 - act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") - - - pmid:28784767 - - act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - + - - - pmid:25001178 - - act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6)) - + - pmid:25001178 + pmid:22908190 - act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin)) + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) - pmid:19126755 + pmid:22908190 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") + p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) - pmid:19126755 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") + path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") + path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") + path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP) - pmid:28445721 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) + path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") - pmid:21482353 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) + path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta") - pmid:21482353 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) + path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT) - pmid:21482353 + pmid:29758300 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) + path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy) + + + + - pmid:21482353 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) - pmid:21482353 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") - pmid:21482353 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") - pmid:21787755 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") - pmid:21787755 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") - pmid:21787755 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") - pmid:28901280 + pmid:30444369 - path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) - pmid:19126755 + pmid:30444369 - bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) - pmid:19126755 + pmid:30444369 - a(MESH:Skin) association act(a(CHEBI:nicotine)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") - pmid:29626319 + pmid:30444369 - a(MESH:Skin) decreases a(CHEBI:"amyloid-beta") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) - pmid:29626319 + pmid:30444369 - a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) - pmid:29626319 + pmid:30444369 - a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") - pmid:19126755 + pmid:30444369 - path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) - pmid:19126755 + pmid:30444369 - path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") + p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:30444369 - path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) - pmid:28901280 + pmid:30444369 - path(MESH:Neoplasms) association p(HGNC:CHRNA7) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) - pmid:22020111 + pmid:30444369 - path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) - pmid:22020111 + pmid:30444369 - path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) - pmid:25784053 + pmid:30444369 - path(MESH:Neoplasms) association act(p(HGNC:HSF1)) + act(p(HGNC:HSD17B10)) association p(FPLX:GABR) + + + + + + + + + + + + + + - pmid:18930136 + pmid:30116051 - path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") + a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) - pmid:24563850 + pmid:30116051 - path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") + a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) + + + + + + + + - pmid:24563850 + pmid:30444369 - path(MESH:Neoplasms) association bp(GO:"protein oxidation") + a(PUBCHEM:5757) decreases a(HBP:"amyloid-beta aggregates") - pmid:29311797 + pmid:30444369 - path(MESH:Neoplasms) association p(HGNC:STUB1) + a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:23746257 + pmid:30444369 - bp(GO:"cell cycle") association p(FPLX:HSP90) + a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) - pmid:30126037 + pmid:30444369 - bp(GO:"cell cycle") association bp(GO:"cellular senescence") + a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(Ph)) - pmid:19126755 + pmid:30444369 - path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") + a(PUBCHEM:5757) increases p(HGNC:BCL2) - pmid:19126755 + pmid:30444369 - path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") + a(PUBCHEM:5757) increases p(HGNC:BCL2L1) - pmid:21718217 + pmid:30444369 - path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) + a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) - pmid:19126755 + pmid:30444369 - path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) + a(PUBCHEM:5757) increases p(HGNC:SOD2) - pmid:19126755 + pmid:30444369 - a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(PUBCHEM:5757) increases p(FPLX:GPX) - pmid:19126755 + pmid:30444369 - a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(FPLX:GABR) association act(p(HGNC:HSD17B10)) - pmid:19126755 + pmid:30444369 - a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) - pmid:19126755 + pmid:30444369 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction") - pmid:24511233 + pmid:30444369 - path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") + a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) - pmid:24590577 + pmid:30444369 - path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") + a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates") - pmid:24027553 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) - pmid:24590577 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) - pmid:24027553 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"methylene blue") increases p(HGNC:BECN1) - pmid:24027553 + pmid:30116051 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:"methylene blue") increases p(HGNC:BECN1) - pmid:24027553 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration)) + a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) - pmid:24027553 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) - pmid:24027553 + pmid:30116051 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) + a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) - pmid:24027553 + pmid:23528736 - path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) - pmid:24027553 + pmid:29758300 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2) + a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) - pmid:24027553 + pmid:30116051 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) + a(CHEBI:"methylene blue") decreases a(HBP:HBP00009) - pmid:24027553 + pmid:30116051 - path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - pmid:24027553 + pmid:30116051 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - pmid:19126755 + pmid:23528736 - path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - pmid:19126755 + pmid:29626319 - p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration) + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - pmid:25514383 + pmid:30116051 - p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) + a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) - pmid:25514383 + pmid:30116051 - p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") + a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) - pmid:25514383 + pmid:30116051 - p(MGI:Chrnb2) increases path(MESH:Attention) + a(CHEBI:"methylene blue") increases p(HGNC:DCTN4) - pmid:25514383 + pmid:24027553 - p(MGI:Chrnb2) increases bp(GO:cognition) + a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) - pmid:27522251 + pmid:22611162 - p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") + a(CHEBI:"methylene blue") increases bp(GO:locomotion) - pmid:27522251 + pmid:29191965 - p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta") + a(CHEBI:"methylene blue") positiveCorrelation bp(GO:locomotion) - pmid:19126755 + pmid:22611162 - p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) + a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") - pmid:19126755 + pmid:23528736 - a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) + a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") - pmid:19293145 + pmid:29191965 - a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta") + a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") - pmid:19293145 + pmid:23528736 - a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:19293145 + pmid:21882945 - a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity) + a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:19293145 + pmid:26751493 - a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity) + a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") - pmid:19293145 + pmid:26751493 - a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) + a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) - pmid:19293145 + pmid:26751493 - a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) + a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) - pmid:26813123 + pmid:23666762 - a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) + a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) - pmid:30145931 + pmid:23666762 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) + a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) - pmid:24760868 + pmid:28287136 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) - pmid:24760868 + pmid:25437566 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) + a(CHEBI:ATP) association act(p(FPLX:HSP90)) - pmid:24760868 + pmid:23746257 - a(HBP:"amyloid-beta oligomers") increases tloc(p(HGNC:MAPT)) + a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) - pmid:23528736 + pmid:25437566 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT) + a(CHEBI:ATP) association act(p(FPLX:HSPA)) - pmid:30145931 + pmid:23746257 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) - pmid:30145931 + pmid:25437566 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + a(CHEBI:ATP) association act(p(HGNC:HSPD1)) - pmid:30145931 + pmid:23746257 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) - pmid:30145931 + pmid:23746257 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) - pmid:24760868 + pmid:23746257 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) - pmid:17403556 + pmid:24457024 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - pmid:17403556 + pmid:24457024 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) - pmid:24760868 + pmid:27671637 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) + a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) + a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1) + a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN) + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24760868 + pmid:24561250 - a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24760868 + pmid:29758300 - a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) - pmid:24760868 + pmid:30116051 - a(HBP:"amyloid-beta oligomers") decreases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) + act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) - pmid:24760868 + pmid:24027553 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) - pmid:24760868 + pmid:24027553 - a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) - pmid:22419736 + pmid:29238289 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CASP3)) increases p(HGNC:MAPT) - pmid:24760868 + pmid:24027553 - a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines")) + act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") - pmid:23528736 + pmid:24027553 - a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) + act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") - pmid:22156579 + pmid:25374103 - act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation p(INTERPRO:"Kinase associated domain 1 (KA1)") + act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau C3") - pmid:19126755 + pmid:24027553 - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) + act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pmid:25374103 - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) + act(p(HGNC:CASP3)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)") + + - pmid:19126755 + pmid:26631930 - act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) - pmid:19126755 + pmid:26631930 - act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) - pmid:19126755 + pmid:27068745 - p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") + p(HGNC:CASP3) association act(p(FPLX:JNK)) - pmid:19126755 + pmid:27068745 - p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") + p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) - pmid:19126755 + pmid:27068745 - p(HGNC:PTGS2) association p(HGNC:CHRNA4) + p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") - pmid:19126755 + pmid:27314526 - a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4) + act(p(HGNC:CASP3)) increases bp(GO:"neuron death") + + + + - pmid:19126755 + pmid:30444369 - path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") + p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") + + - pmid:19126755 + pmid:23528736 - path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") + p(HGNC:BCL2L11) decreases bp(GO:autophagy) - pmid:19126755 + pmid:30444369 - path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") + act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:30444369 - path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) + p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:19721446 + pmid:30444369 - path(MESH:Craving) association p(HGNC:CHRNA3) + p(HGNC:PRDX2, pmod(Ph, Thr, 89)) decreases act(p(HGNC:PRDX2)) - pmid:19721446 + pmid:30444369 - path(MESH:Craving) association p(HGNC:CHRNB4) + p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") - pmid:17009926 + pmid:30444369 - path(MESH:Anxiety) association p(FPLX:CHRN) + p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:11230871 + pmid:30444369 - path(MESH:Anxiety) association p(FPLX:CHRN) + p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) - pmid:21482353 + pmid:30444369 - path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") + p(HGNC:SH3GL2) association bp(GO:"neuron projection development") - pmid:28901280 + pmid:30444369 - path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") + p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") - pmid:28775333 + pmid:30444369 - path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) + p(HGNC:SH3GL2) association bp(GO:"neuron death") - pmid:19126755 + pmid:30444369 - a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine) + bp(GO:"neuron projection development") association p(HGNC:SH3GL2) - pmid:19126755 + pmid:20133804 - a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) + bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) - pmid:19126755 + pmid:30444369 - path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) + a(HBP:AG18051) decreases act(p(HGNC:HSD17B10)) - pmid:19126755 + pmid:30444369 - path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR") + a(HBP:AG18051) decreases act(a(HBP:"amyloid-beta aggregates")) - pmid:19126755 + pmid:30444369 - a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") + a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10)) - pmid:11230871 + pmid:30444369 - a(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging) + a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) - pmid:11230871 + pmid:30444369 - a(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) - pmid:19293145 + pmid:30444369 - path(MESH:Death) association path(MESH:"Alzheimer Disease") + p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(Ph)) - pmid:19293145 + pmid:30444369 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) - pmid:19293145 + pmid:30444369 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + p(HGNC:CSNK1A1) association a(HBP:"amyloid-beta aggregates") - pmid:14556719 + pmid:25974414 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) - pmid:14556719 + pmid:25673844 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) + p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) - pmid:27574109 + pmid:25546293 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 35)) - pmid:14556719 + pmid:30444369 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + a(PUBCHEM:208907) decreases act(p(HGNC:MAOA)) - pmid:14556719 + pmid:30444369 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + a(PUBCHEM:208907) causesNoChange act(p(HGNC:CSNK1A1)) - pmid:14556719 + pmid:22040696 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) - pmid:27574109 + pmid:29758300 - a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers") + path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(HBP:"protein aggregates") - pmid:27574109 + pmid:29758300 - a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") + path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") - pmid:23528736 + pmid:22908190 - a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") + path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") - pmid:19293145 + pmid:25784053 - a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") + path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") - pmid:16273023 + pmid:18930136 - a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") + path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(HBP:misfolding)) - pmid:16273023 + pmid:18930136 - a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) + path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) - pmid:21882945 + pmid:18930136 - a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) + path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) - - - - - - - pmid:19293145 + pmid:29024336 - composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) + path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") - - - - - pmid:19293145 + pmid:29024336 - a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta") + path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") - pmid:17403556 + pmid:24027553 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) - pmid:17403556 + pmid:23528736 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) - pmid:17403556 + pmid:23528736 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) - pmid:17403556 + pmid:23528736 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) - pmid:17403556 + pmid:23528736 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) - pmid:17403556 + pmid:23528736 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) - pmid:19293145 + pmid:29191965 - a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning") + path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") - pmid:19293145 + pmid:29311797 - p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) + path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) - pmid:18986241 + pmid:29196815 - act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine)) + path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:21482353 - p(HGNC:BCHE) association a(MESH:D016874) + path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") - pmid:18986241 + pmid:22807490 - p(HGNC:BCHE) association path(MESH:D058225) + path(MESH:Smoking) association path(MESH:"Hashimoto Disease") - - - pmid:18986241 + pmid:22807490 - p(HGNC:BCHE) association path(MESH:D003071) + path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") - pmid:19293145 + pmid:22807490 - g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") + path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) - pmid:19293145 + pmid:28391535 - g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") + path(MESH:Smoking) increases a(MESH:"Blood Glucose") - pmid:19293145 + pmid:29196815 - bp(MESH:Neuroprotection) association p(HGNC:FYN) + path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:29196815 - bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") + path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:26195256 - bp(MESH:Neuroprotection) association a(MESH:Calcineurin) + path(MESH:"Diabetes Mellitus") association path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:29626319 - bp(MESH:Neuroprotection) association p(HGNC:JAK2) + path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) - pmid:19721446 + pmid:29626319 - bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) + path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:29196815 - bp(MESH:Neuroprotection) association a(CHEBI:nicotine) + g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:26837465 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) + complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) - pmid:19293145 + pmid:26837465 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) + complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) - pmid:19293145 + pmid:24368848 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) + complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) - pmid:19293145 + pmid:23407988 - a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection) + complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") - pmid:17009926 + pmid:10391244 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) + complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) - pmid:17009926 + pmid:10391244 - a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory) + complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) - pmid:19293145 + pmid:12714745 - a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) + complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) - pmid:17009926 + pmid:29196815 - a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") + a(HBP:HBP00074) increases bp(GO:"neuron death") - pmid:17009926 + pmid:29196815 - a(CHEBI:Mecamylamine) decreases path(MESH:Attention) + a(HBP:HBP00074) increases bp(GO:"neuron death") - pmid:26813123 + pmid:29196815 - a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) + a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death") - pmid:11230871 + pmid:21718217 - a(CHEBI:Mecamylamine) decreases bp(GO:cognition) + a(HBP:HBP00074) increases bp(GO:"neuron death") - pmid:19721446 + pmid:29196815 - a(CHEBI:Mecamylamine) decreases bp(GO:cognition) + a(HBP:HBP00074) decreases a(MESH:Synapses) - pmid:23038257 + pmid:29196815 - bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) + a(HBP:HBP00074) decreases a(MESH:Synapses) - - - - - pmid:19293145 + pmid:29196815 - a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta")) + a(HBP:HBP00074) decreases a(MESH:Synapses) - pmid:19293145 + pmid:29196815 - a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + a(HBP:HBP00074) decreases bp(GO:memory) - pmid:19293145 + pmid:29196815 - act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph)) + a(HBP:HBP00074) decreases bp(GO:memory) - pmid:23038257 + pmid:29196815 - a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") + a(HBP:HBP00074) decreases bp(GO:memory) - pmid:23038257 + pmid:29196815 - a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) + a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23038257 + pmid:29196815 - a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) + a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pmid:29196815 - a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") - pmid:28445721 + pmid:29196815 - a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(HBP:HBP00074) increases path(MESH:Dementia) - - - - - pmid:19293145 + pmid:29196815 - composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) + a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") - pmid:19293145 + pmid:29196815 - act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity) + a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") - pmid:19293145 + pmid:29196815 - a(MESH:Serum) decreases bp(GO:"cell death") + a(HBP:HBP00074) decreases bp(GO:"signal release from synapse") - pmid:24027553 + pmid:29196815 - bp(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") - pmid:24183963 + pmid:29196815 - a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph)) - pmid:24183963 + pmid:29196815 - a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") - pmid:16630055 + pmid:29196815 - a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) + a(HBP:HBP00074) increases bp(GO:"microglial cell activation") - pmid:19293145 + pmid:29196815 - a(CHEBI:thapsigargin) increases bp(GO:"cell death") + a(HBP:HBP00074) increases bp(GO:"astrocyte activation") - pmid:19293145 + pmid:29196815 - a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") + a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation") - pmid:29024336 + pmid:29196815 - a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") + a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") - pmid:19293145 + pmid:29196815 - act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) + a(HBP:HBP00074) increases act(p(HGNC:GRIN1)) - pmid:19293145 + pmid:29196815 - act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) + a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:19293145 + pmid:29196815 - a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity) + a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:19293145 + pmid:29196815 - act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration) + a(HBP:HBP00074) increases act(p(HGNC:NGFR)) - pmid:26813123 + pmid:29196815 - bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory) + a(HBP:HBP00074) decreases p(HGNC:INSR) - pmid:26813123 + pmid:29196815 - bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") + a(HBP:HBP00074) negativeCorrelation a(HBP:HBP00352) - pmid:26813123 + pmid:29196815 - bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") + a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:18986241 + pmid:29196815 - bp(HBP:Neurodegeneration) association path(MESH:D060825) + a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:19293145 + pmid:21718217 - act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) + a(HBP:HBP00074) decreases bp(GO:"synaptic signaling") @@ -40361,34 +41400,34 @@

Statements

pmid:19293145 - act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") + a(MESH:Synapses) increases bp(GO:cognition) - pmid:23702978 + pmid:29196815 - act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) + a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) - pmid:23702978 + pmid:29196815 - act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) + a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) - pmid:19293145 + pmid:19126755 - bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) + path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") @@ -40397,34 +41436,34 @@

Statements

pmid:19293145 - p(FPLX:SRC) increases act(a(CHEBI:nicotine)) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:24511233 - act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph)) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:25514383 - act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:26813123 - act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) + path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") @@ -40433,488 +41472,476 @@

Statements

pmid:25514383 - p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process") + path(MESH:Dementia) association bp(GO:aging) - - - pmid:19293145 + pmid:29758300 - act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") + path(MESH:Dementia) association path(MESH:Tauopathies) - pmid:19293145 + pmid:22908190 - p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") + path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") - pmid:25514383 + pmid:22908190 - act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) + path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") - pmid:25331948 + pmid:22908190 - p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) - pmid:29121589 + pmid:26631930 - p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT) - - - pmid:29121589 + pmid:27314526 - p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) + path(MESH:Dementia) association sec(a(MESH:Interleukins)) - pmid:19293145 + pmid:27314526 - a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) + path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) - - - pmid:19293145 + pmid:27314526 - tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") + path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) - - - + + + pmid:24653673 + + p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B)) + - pmid:19293145 + pmid:24653673 - p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5)) - pmid:18680553 + pmid:24653673 - p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK)) - pmid:19293145 + pmid:24653673 - p(HGNC:FYN) increases bp(GO:cognition) + p(HGNC:APP, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) - pmid:19293145 + pmid:24653673 - p(HGNC:FYN) increases act(p(FPLX:PI3K)) + p(HGNC:APP, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) - pmid:19293145 + pmid:29196815 - p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph)) + bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074) - pmid:19293145 + pmid:27671637 - p(HGNC:FYN) decreases bp(GO:"apoptotic process") + bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:19293145 + pmid:27314526 - p(HGNC:FYN) association bp(MESH:Neuroprotection) + bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) - pmid:19293145 + pmid:27314526 - p(HGNC:FYN) increases bp(MESH:Neuroprotection) + bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) - pmid:19293145 + pmid:27314526 - p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta")) + bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) - pmid:19293145 + pmid:27314526 - p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) + bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) - pmid:19293145 + pmid:29196815 - p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) + act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) - pmid:19293145 + pmid:29196815 - p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) + act(p(HGNC:GRIN1)) increases path(HBP:HBP00068) - pmid:24760868 + pmid:29196815 - p(HGNC:FYN, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + act(p(HGNC:GRIN1)) increases path(HBP:HBP00037) - pmid:30640040 + pmid:29196815 - p(HGNC:FYN) association a(PUBCHEM:4878) + act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) - pmid:29191965 + pmid:24760868 - p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + p(HGNC:GRIA1, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:26751493 + pmid:24760868 - p(HGNC:FYN) association p(HBP:"projection domain") + p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:26631930 + pmid:29196815 - p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + a(HBP:HBP00075) decreases p(MGI:Adrb2) - pmid:17493042 + pmid:29196815 - p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + a(HBP:HBP00075) increases bp(GO:"microglial cell activation") - pmid:26631930 + pmid:29196815 - p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph)) + a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation") - - - pmid:18680553 - - p(HGNC:FYN) association p(HGNC:MAPT) - + - pmid:18680553 + pmid:29196815 - p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226")) + complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") - pmid:18680553 + pmid:29196815 - p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") - pmid:26751493 + pmid:14556719 - p(HGNC:FYN) association a(HBP:"projection domain") + p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) - - - pmid:19293145 + pmid:14556719 - complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) + tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) - - - pmid:19293145 + pmid:28420982 - p(MGI:Fyn) decreases bp(MESH:Neuroprotection) + p(HGNC:PRNP) association a(HBP:"Tau oligomers") - - - pmid:18096814 + pmid:29196815 - p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") - pmid:18096814 + pmid:29196815 - p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) - pmid:25125464 + pmid:29196815 - p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") + a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") + + + + - pmid:25125464 + pmid:29196815 - act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) + p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25125464 + pmid:29196815 - act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8") + p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:19293145 + pmid:18986241 - p(HGNC:SRC) increases bp(MESH:Neuroprotection) + p(HGNC:NGFR) association bp(GO:"GO:1901214") - pmid:24653673 + pmid:18986241 - p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + p(HGNC:NGFR) increases act(p(HGNC:BACE1)) - pmid:24653673 + pmid:18986241 - p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta") - pmid:24653673 + pmid:18986241 - p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + act(p(HGNC:NGFR)) association bp(GO:"GO:0006665") - pmid:24653673 + pmid:18986241 - p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254") - pmid:29191965 + pmid:18986241 - p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061") - pmid:26751493 + pmid:18986241 - p(HGNC:SRC) association p(HBP:"projection domain") + act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") - - - pmid:18467332 + pmid:18986241 - p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) + act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165") - pmid:26751493 + pmid:22142809 - p(HGNC:SRC) association a(HBP:"projection domain") + p(HGNC:NGFR) association p(HBP:RAC1b) - pmid:19293145 + pmid:29196815 - p(HGNC:JAK2) increases bp(MESH:Neuroprotection) + a(HBP:HBP00352) negativeCorrelation a(HBP:HBP00074) - pmid:19293145 + pmid:29196815 - p(HGNC:JAK2) association bp(MESH:Neuroprotection) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) - pmid:19293145 + pmid:29196815 - p(HGNC:JAK2) increases act(a(CHEBI:nicotine)) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) - pmid:19293145 + pmid:29196815 - act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) + path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) @@ -40923,7 +41950,7 @@

Statements

pmid:19293145 - p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers") @@ -40932,279 +41959,277 @@

Statements

pmid:19293145 - p(HGNC:JAK2) association act(p(HGNC:STAT3)) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:24511233 - p(HGNC:JAK2) increases act(p(HGNC:FYN)) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - - - - - pmid:19293145 + pmid:24511233 - complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - pmid:24653673 + pmid:26813123 - complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pmid:24511233 - complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(HBP:Excitotoxicity) + path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) - pmid:18680553 + pmid:26813123 - complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) + path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) - pmid:19293145 + pmid:26813123 - p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph)) + path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) - pmid:26631930 + pmid:27522251 - p(HGNC:MAPT, pmod(Ph, Tyr)) increases a(HBP:"Tau aggregates") + path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") - - - - - - - pmid:19293145 + pmid:21482353 - p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr)) + path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) - pmid:19293145 + pmid:11230871 - p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2)) + path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) - pmid:19293145 + pmid:24027553 - a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) - pmid:19293145 + pmid:30108137 - a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) - pmid:19293145 + pmid:30126037 - a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) + path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) - pmid:17009926 + pmid:30126037 - a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) + path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") - pmid:17009926 + pmid:19765634 - a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN)) + path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) - pmid:17009926 + pmid:19765634 - a(CHEBI:genistein) regulates p(FPLX:CHRN) + path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) - pmid:19293145 + pmid:29196815 - p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine)) + a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23038257 + pmid:29196815 - p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:18650430 - p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7)) + p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:14556719 - a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta")) + p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:22908190 - a(CHEBI:estradiol) decreases path(HBP:neurotoxicity) + p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23178521 + pmid:22908190 - p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine) + p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - - - + + + pmid:18650430 + + p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") + - pmid:19293145 + pmid:14556719 - act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) + p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates") - pmid:19293145 + pmid:22908190 - act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) + p(HGNC:APP, var("?")) increases bp(GO:endocytosis) - + + + pmid:22908190 + + p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) + - pmid:19293145 + pmid:28420982 - composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) + path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") - pmid:19293145 + pmid:18650430 - act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") + act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:19293145 + pmid:21214928 - g(HGNC:NIN) association g(HGNC:GSK3B) + p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19293145 + pmid:22122372 - g(HGNC:GSK3B) association g(HGNC:NIN) + p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19293145 + pmid:22122372 - act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") + p(HGNC:ADAM17) increases a(HBP:HBP00067) @@ -41213,1338 +42238,1274 @@

Statements

+ + - pmid:19293145 + pmid:18650430 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") + act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:19293145 + pmid:22122372 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) + p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19293145 + pmid:22122372 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") + p(HGNC:ADAM9) increases a(HBP:HBP00067) - pmid:19293145 + pmid:18650430 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph)) + act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:19293145 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph)) + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:19293145 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph)) + p(HGNC:ADAM10) increases p(HBP:HBP00067) - pmid:19293145 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph)) + p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) + p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:22122372 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") + p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19721446 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19721446 + pmid:22122372 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19721446 + pmid:22122372 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) - pmid:19721446 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") + p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19721446 + pmid:21214928 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) + act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19721446 + pmid:22122372 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) + p(HGNC:ADAM10) increases sec(p(HGNC:APP)) - pmid:19721446 + pmid:24590577 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) + p(HGNC:ADAM10) increases deg(p(HGNC:APP)) - + + + pmid:22122372 + + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072))) + - pmid:30640040 + pmid:22122372 - act(p(HGNC:MAPK14)) increases a(HBP:"Tau aggregates") + p(HGNC:ADAM10) increases a(HBP:HBP00067) - pmid:30640040 + pmid:22122372 - p(HGNC:MAPK14) association a(PUBCHEM:11570805) + p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") - pmid:30640040 + pmid:24590577 - p(HGNC:MAPK14) association a(PUBCHEM:156422) + p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha") - pmid:30640040 + pmid:18650430 - p(HGNC:MAPK14) association a(PUBCHEM:10341154) + act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:11943212 + pmid:21214928 - p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - pmid:18494933 + pmid:21214928 - p(HGNC:MAPK8, pmod(Ph)) increases act(p(HGNC:MAPK8)) + p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - - - pmid:23528736 - - p(HGNC:MAPK8) increases bp(GO:autophagy) - + - - - pmid:23528736 - - p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) - + - - - pmid:23528736 - - p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph)) - + - - - pmid:18494933 - - act(p(HGNC:MAPK8)) increases p(HGNC:JUN) - + - pmid:11943212 + pmid:18650430 - p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") - pmid:19293145 + pmid:18650430 - a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph)) + complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) - pmid:19293145 + pmid:22122372 - a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph)) + complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) - pmid:19293145 + pmid:21214928 - a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941")) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - pmid:30640040 + pmid:22122372 - p(FPLX:NFkappaB) association a(PUBCHEM:5318517) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - pmid:26118667 + pmid:21214928 - p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072))) - - - pmid:19293145 + pmid:21214928 - act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") + complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?")) - pmid:29559585 + pmid:21214928 - a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) - pmid:27601475 + pmid:21214928 - a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP") + complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) - pmid:23702978 + pmid:21214928 - a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) - pmid:27314526 + pmid:21214928 - a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) + complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) - pmid:27314526 + pmid:21214928 - a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) - pmid:27314526 + pmid:22122372 - a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) - pmid:27314526 + pmid:22122372 - a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") + complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) - - - - - pmid:19293145 + pmid:22122372 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) - pmid:19293145 + pmid:22122372 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) - pmid:19293145 + pmid:22122372 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) - pmid:19293145 + pmid:24590577 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph)) + complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99)) - pmid:19293145 + pmid:24590577 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine)) + complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") - - - - - - - - - pmid:19293145 + pmid:29626319 - composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) + complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:24590577 - p(FPLX:ERK) association a(CHEBI:nicotine) + complex(FPLX:"Gamma_secretase") increases a(HBP:AICD) + + - pmid:24653673 + pmid:21718217 - act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") + p(HGNC:APH1A) decreases p(HGNC:APP) - pmid:24653673 + pmid:21718217 - act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24653673 + pmid:18650430 - act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta") - pmid:24653673 + pmid:18650430 - act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing") + p(HGNC:APBA1) decreases a(HBP:HBP00018) - pmid:24653673 + pmid:18650430 - act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) + p(HGNC:APBA1) regulates bp(HBP:HBP00073) - pmid:24653673 + pmid:21214928 - act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + bp(HBP:HBP00073) association p(HGNC:RAB6A) - pmid:24653673 + pmid:22122372 - act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") + bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:8282104 + pmid:22122372 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) - pmid:8282104 + pmid:22122372 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:8282104 + pmid:30116051 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta") - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:APBA2) decreases a(HBP:HBP00018) - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:APBA2) regulates bp(HBP:HBP00073) - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) association a(GO:microtubule) + p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta") - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) association a(HBP:HBP00006) + p(HGNC:APBB1) decreases a(HBP:HBP00018) - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + p(HGNC:APBB1) regulates bp(HBP:HBP00073) - pmid:8282104 + pmid:18650430 - p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:APBB1) increases a(HBP:HBP00071) - pmid:27594586 + pmid:21214928 - p(FPLX:ERK) regulates p(HGNC:MMP9) + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) - - - pmid:24686445 + pmid:21214928 - act(p(FPLX:ERK)) positiveCorrelation act(p(HGNC:KAT2B)) + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) - pmid:19293145 + pmid:21214928 - act(p(FPLX:RAS)) increases p(HGNC:STAT3) + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) - pmid:18986241 + pmid:21214928 - p(FPLX:RAS) association bp(GO:"GO:0014065") + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) - pmid:18986241 + pmid:21214928 - p(FPLX:RAS) association bp(GO:"GO:0043491") + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) - - - - - pmid:19293145 + pmid:21214928 - composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph)) + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) - pmid:19293145 + pmid:21214928 - act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity) + act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) - pmid:18494933 + pmid:21214928 - p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER)) + a(HBP:HBP00071) increases bp(GO:"apoptotic process") - pmid:18494933 + pmid:18650430 - p(FPLX:JNK) increases p(HGNC:DKK1) + p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") - pmid:18494933 + pmid:21214928 - act(p(FPLX:JNK)) increases p(HGNC:DKK1) + p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") - - - pmid:18494933 + pmid:29758300 - act(p(FPLX:JNK)) positiveCorrelation p(FPLX:JNK, pmod(Ph)) + p(HGNC:SORL1) negativeCorrelation a(CHEBI:"amyloid-beta") - pmid:27068745 + pmid:29758300 - act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1") + p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") - pmid:27068745 + pmid:21214928 - act(p(FPLX:JNK)) association p(HGNC:CASP3) + bp(GO:"synapse assembly") association p(HGNC:APP) - pmid:19293145 + pmid:30106381 - bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta")) + bp(GO:"synapse assembly") association p(HGNC:ADNP) - pmid:19293145 + pmid:30106381 - bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) + bp(GO:"synapse assembly") association a(PUBCHEM:9832404) - - - pmid:19293145 - - bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) - + - pmid:19293145 + pmid:18650430 - bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) + composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) - pmid:19293145 + pmid:26813123 - bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:23746257 + pmid:26813123 - bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:25514383 + pmid:26813123 - bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR") + p(HGNC:SLC5A7) increases a(CHEBI:choline) - pmid:25514383 + pmid:26813123 - bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:21482353 + pmid:26813123 - bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) - pmid:19293145 + pmid:17293005 - a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) + p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta")) - pmid:19721446 + pmid:17293005 - a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") + p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta") - pmid:19293145 + pmid:17293005 - a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) + p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha")) - pmid:19293145 + pmid:17293005 - p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) + p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) - pmid:19293145 + pmid:17293005 - act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") + p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha") - - - pmid:19293145 + pmid:17293005 - p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) + p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:17293005 - act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") + p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) - pmid:19293145 + pmid:17293005 - a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) + p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) - pmid:19293145 + pmid:17293005 - a(MESH:Calcineurin) association bp(MESH:Neuroprotection) + p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") - - - - - - - pmid:19293145 + pmid:17293005 - composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph)) + p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta")) - pmid:19293145 + pmid:17293005 - bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") + p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha")) - - - - - pmid:19293145 + pmid:17293005 - composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis") + p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta") - - - - - - - - - pmid:19293145 + pmid:17293005 - composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") + p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) - - - - - pmid:19293145 + pmid:17293005 - composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta")) - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) increases p(HGNC:APOE) + p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta") - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha")) - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) + p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha") - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) + p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta") - pmid:19293145 + pmid:17293005 - g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) - pmid:19293145 + pmid:17293005 - p(HGNC:APOE) association bp(GO:"lipid metabolic process") + p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) - pmid:19293145 + pmid:17293005 - p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21718217 + pmid:17293005 - p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") + p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta")) - pmid:21718217 + pmid:17293005 - p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha")) - pmid:21718217 + pmid:17293005 - act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta") - pmid:26195256 + pmid:17293005 - p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") + p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) + + + + - pmid:26195256 + pmid:21214928 - p(HGNC:APOE) decreases act(a(CHEBI:"amyloid-beta")) + rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2) - pmid:26195256 + pmid:21214928 - p(HGNC:APOE) regulates a(CHEBI:"amyloid-beta") + a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - - - pmid:19293145 + pmid:26813123 - bp(GO:"lipid metabolic process") association p(HGNC:APOE) + a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") - pmid:19293145 + pmid:14556719 - bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) + a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) - pmid:19293145 + pmid:21214928 - p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - - - - - pmid:19293145 + pmid:21214928 - act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol) + a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") - pmid:24590577 + pmid:21214928 - a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) + a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) - pmid:26751493 + pmid:21214928 - a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) - pmid:26751493 + pmid:21214928 - a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain") + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) - pmid:19293145 + pmid:22122372 - p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) - pmid:26195256 + pmid:29215007 - p(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") + a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) - pmid:26195256 + pmid:21214928 - p(HBP:"APOE e4") regulates a(MESH:"Blood-Brain Barrier") + bp(HBP:HBP00077) increases p(HBP:HBP00063) - pmid:26195256 + pmid:21214928 - p(HBP:"APOE e4") decreases bp(HBP:"perivascular drainage pathways") + bp(HBP:HBP00077) increases p(HBP:HBP00064) - pmid:27087442 + pmid:21214928 - p(HBP:"APOE e4") increases p(MGI:Cdk5) + bp(HBP:HBP00077) increases p(HBP:HBP00065) - pmid:27087442 + pmid:22122372 - p(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25") + bp(HBP:HBP00077) increases a(HBP:HBP00063) - pmid:27087442 + pmid:22122372 - p(HBP:"APOE e4") increases p(MGI:Cdk5r1) + bp(HBP:HBP00077) increases a(HBP:HBP00064) - pmid:27087442 + pmid:21214928 - p(HBP:"APOE e4") increases p(MGI:Capn1) + p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7) - pmid:27087442 + pmid:21214928 - p(HBP:"APOE e4") increases p(MGI:Capn2) + p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid") - pmid:27087442 + pmid:21214928 - p(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b) + p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7) - pmid:28720530 + pmid:21214928 - p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E) + p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid") - pmid:28720530 + pmid:21214928 - p(HBP:"APOE e4") negativeCorrelation complex(GO:"protein phosphatase type 2A complex") + p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pmid:21214928 - a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) + p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064) - pmid:30145931 + pmid:21214928 - a(CHEBI:wortmannin) decreases bp(GO:autophagy) + p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065) - pmid:30145931 + pmid:21214928 - a(CHEBI:wortmannin) increases p(HGNC:MAPT) + r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30145931 + pmid:21214928 - a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + bp(GO:"signal transduction") association p(HGNC:APP) - pmid:30145931 + pmid:17403556 - a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) - pmid:30145931 + pmid:29311797 - a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(GO:"signal transduction") association p(HGNC:HSP90AB1) - pmid:30145931 + pmid:21214928 - a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(GO:"protein transport") association p(HGNC:APP) - pmid:30145931 + pmid:23746257 - a(CHEBI:wortmannin) decreases a(MESH:"Dendritic Spines") + bp(GO:"protein transport") association p(FPLX:HSP90) @@ -42555,18 +43516,22 @@

Statements

- pmid:19293145 + pmid:22122372 - composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) + + + + - pmid:19293145 + pmid:22122372 - composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) + complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) @@ -42577,93 +43542,87 @@

Statements

- pmid:22040696 + pmid:22122372 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) + complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) - pmid:19293145 + pmid:27068745 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity) + p(HGNC:NTN1) decreases p(HGNC:UNC5C, var("p.Thr835Met")) - pmid:19293145 + pmid:21214928 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) + bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) - pmid:18986241 + pmid:21734277 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) + bp(GO:"anterograde axonal protein transport") association p(HBP:"6D tau", frag("2_18")) + + + + - pmid:18986241 + pmid:21214928 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271") + complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) - pmid:22040696 + pmid:21214928 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") + complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) - - - - - pmid:19293145 + pmid:19491104 - composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) + p(HGNC:KIF5B) isA complex(GO:"kinesin complex") - - - - - pmid:19293145 + pmid:19491104 - composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:KIF5B) association complex(GO:microtubule) - - - pmid:19293145 + pmid:26813123 - composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) @@ -42672,433 +43631,387 @@

Statements

+ + - pmid:19293145 + pmid:21214928 - complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") + a(HBP:HBP00067) decreases bp(HBP:HBP00061) - pmid:19293145 + pmid:22122372 - bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) + a(HBP:HBP00067) decreases bp(HBP:HBP00061) - pmid:24653673 + pmid:22122372 - bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061) - pmid:24653673 + pmid:21214928 - bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pmid:21214928 - bp(GO:"insulin receptor signaling pathway") positiveCorrelation composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) + a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") - pmid:19293145 + pmid:21214928 - bp(GO:"choline transport") association a(CHEBI:"amyloid-beta") + a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") - - - - - pmid:19293145 + pmid:21214928 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + a(HBP:HBP00067) decreases bp(HBP:HBP00068) - pmid:19293145 + pmid:21214928 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + a(HBP:HBP00067) decreases bp(HBP:HBP00068) - pmid:19293145 + pmid:21214928 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) + a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation") - - - - - pmid:25514383 + pmid:21214928 - a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(HBP:HBP00067) decreases act(p(HGNC:CDK5)) - pmid:25514383 + pmid:21214928 - a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) + a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) - - - - - pmid:19293145 + pmid:21214928 - p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:19293145 + pmid:21214928 - p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) + a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) - - - - - - - - - - - pmid:19721446 + pmid:21214928 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:21482353 + pmid:21214928 - p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) + a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:19293145 + pmid:21214928 - a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) + sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:26813123 + pmid:21214928 - act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) + sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester") - pmid:26813123 + pmid:22122372 - a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) + a(HBP:HBP00067) increases bp(GO:"cell adhesion") - pmid:26813123 + pmid:22122372 - a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) + a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth") - pmid:26813123 + pmid:22122372 - a(MESH:"Cholinergic Neurons") increases bp(GO:memory) + a(HBP:HBP00067) increases bp(GO:"synapse assembly") - pmid:26813123 + pmid:22122372 - a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") + a(HBP:HBP00067) increases bp(GO:learning) - pmid:26813123 + pmid:22122372 - a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) + a(HBP:HBP00067) increases bp(GO:memory) - - - pmid:26813123 - - a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) - - - - - pmid:26813123 - - a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) - + - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") + composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067) - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) + a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067)) - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) + a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta") - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") + bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) - pmid:26813123 + pmid:12428809 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") + bp(GO:"regulation of neuronal synaptic plasticity") association sec(p(HGNC:APP)) - - - pmid:26813123 - - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - + - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") + complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - - - pmid:26813123 - - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") - + - pmid:26813123 + pmid:21214928 - a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) + complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) - pmid:28901280 + pmid:19126755 - a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) + bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:26813123 - r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:19293145 - r(HGNC:CHRNA7) regulates act(a(MESH:D059329)) + bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") - pmid:18986241 + pmid:19293145 - r(HGNC:CHRNA7) increases path(MESH:D009410) + bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") - pmid:11230871 + pmid:24511233 - r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - - - - - pmid:19293145 + pmid:26813123 - composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - pmid:19293145 + pmid:21482353 - composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - pmid:23038257 + pmid:24511233 - a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) - pmid:23038257 + pmid:24511233 - a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) - pmid:23038257 + pmid:17009926 - a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) + bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) - pmid:23038257 + pmid:26813123 - a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) + bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) @@ -43107,7 +44020,7 @@

Statements

pmid:26813123 - a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) @@ -43116,7 +44029,7 @@

Statements

pmid:26813123 - act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") + bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) @@ -43125,7 +44038,7 @@

Statements

pmid:26813123 - a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) @@ -43134,7 +44047,7 @@

Statements

pmid:26813123 - act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) @@ -43143,1155 +44056,1045 @@

Statements

pmid:26813123 - act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) - pmid:19721446 + pmid:21482353 - a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) - pmid:23038257 + pmid:26813123 - a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:23038257 + pmid:21482353 - a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) - pmid:23038257 + pmid:22040696 - a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) + bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) - - - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") - pmid:28901280 + pmid:21482353 - p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) + bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") + bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration) - pmid:28901280 + pmid:26813123 - p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation") + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) - pmid:28901280 + pmid:24590577 - p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") - pmid:28901280 + pmid:24590577 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") - pmid:28901280 + pmid:21482353 - p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) - pmid:28901280 + pmid:21482353 - p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) - pmid:28901280 + pmid:21482353 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") + bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) - pmid:28901280 + pmid:11230871 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") + bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) - pmid:28901280 + pmid:21214928 - p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) + p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) - pmid:28901280 + pmid:21214928 - p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) + p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) - pmid:28901280 + pmid:22122372 - p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) + p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) - pmid:28901280 + pmid:21214928 - p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") - pmid:28901280 + pmid:21214928 - p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters) + p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) - pmid:23038257 + pmid:22122372 - p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) + p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) - - - pmid:23038257 + pmid:21214928 - a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:19721446 + pmid:22122372 - a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:2833519 + pmid:22122372 - a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:23038257 + pmid:27094130 - a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) + sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) - pmid:23038257 + pmid:29540553 - a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) + p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3) - pmid:23038257 + pmid:29559585 - p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) + p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac)) - pmid:23038257 + pmid:29559585 - a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") + p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") - pmid:23038257 + pmid:22122372 - a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") + p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061) - pmid:19721446 + pmid:27094130 - a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + sec(p(HGNC:APP, frag("672_711"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) - pmid:23038257 + pmid:24401760 - p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr)) + p(HGNC:APP, frag("672_711")) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:23038257 + pmid:21214928 - p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + path(MESH:"Down Syndrome") increases a(HBP:HBP00018) - - - pmid:22040696 + pmid:17009926 - p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") + path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) - pmid:23038257 + pmid:17009926 - p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin)) + path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) - pmid:23038257 + pmid:26813123 - p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) + path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:24511233 + pmid:22299660 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) - pmid:24511233 + pmid:22908190 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") - pmid:24511233 + pmid:21214928 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:22122372 - path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) + p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:22908190 - path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) + p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) - - - pmid:22040696 - - path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) - + - pmid:24511233 + pmid:21214928 - path(MESH:Hallucinations) association path(MESH:Schizophrenia) + complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") - pmid:24511233 + pmid:21214928 - path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) + complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") - pmid:19721446 + pmid:21214928 - path(MESH:Hallucinations) association path(MESH:Schizophrenia) + a(HBP:HBP00042) increases p(HGNC:TTR) - pmid:24511233 + pmid:21214928 - path(MESH:Delusions) association path(MESH:Schizophrenia) + a(HBP:HBP00042) increases p(HGNC:KL) - pmid:24511233 + pmid:22122372 - path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) + a(HBP:HBP00042) increases bp(HBP:HBP00061) - pmid:19721446 + pmid:21214928 - path(MESH:Delusions) association path(MESH:Schizophrenia) + bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) - pmid:24511233 + pmid:21214928 - bp(GO:behavior) association path(MESH:Schizophrenia) + a(HBP:HBP00024) increases bp(HBP:HBP00027) - - - pmid:24511233 - - bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") - + - - - pmid:28420982 - - bp(GO:behavior) association p(HGNC:MAPT) - + - pmid:24511233 + pmid:22122372 - p(HGNC:CHRM1) association bp(GO:cognition) + act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) + + - pmid:24511233 + pmid:22122372 - act(p(HGNC:CHRM1)) increases bp(GO:cognition) + act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) + + - pmid:24590577 + pmid:22122372 - act(p(HGNC:CHRM1)) increases bp(GO:cognition) + act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:24511233 + pmid:22122372 - p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) + p(HBP:HBP00071) increases bp(GO:"cell death") - pmid:24511233 + pmid:22122372 - p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") + p(HBP:HBP00071) increases p(HGNC:TP53) - pmid:24511233 + pmid:22122372 - p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HBP:HBP00071) increases act(p(HGNC:TP53)) - pmid:24511233 + pmid:22122372 - act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") - pmid:24511233 + pmid:22122372 - p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") + a(HBP:HBP00069) increases bp(HBP:HBP00061) - pmid:24511233 + pmid:22122372 - act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) + a(HBP:HBP00069) increases act(p(HGNC:CASP3)) - pmid:24511233 + pmid:22122372 - act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha")) + a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) - pmid:24590577 + pmid:22122372 - act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") + a(HBP:HBP00070) increases bp(HBP:HBP00061) - - - pmid:26813123 - - act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") - + - - - pmid:26813123 - - act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") - + - - - pmid:26813123 - - act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) - + - pmid:26813123 + pmid:21214928 - act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta")) + complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) - - - pmid:24590577 - - act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") - + + + - pmid:26813123 + pmid:21214928 - act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta") - pmid:26813123 + pmid:21214928 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta") - pmid:24590577 + pmid:21214928 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta") - - - pmid:24590577 - - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - + + + - pmid:24590577 + pmid:21214928 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta") - - - pmid:26813123 - - act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) - + - - - pmid:24590577 - - act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) - + + + - pmid:24590577 + pmid:21718217 - p(HGNC:CHRM1) association a(MESH:Hippocampus) + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association a(MESH:Thalamus) + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association bp(GO:learning) + act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:28250274 - p(HGNC:CHRM1) association bp(GO:memory) + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:30116051 - p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:24590577 + pmid:29626319 - p(HGNC:CHRM1) association bp(GO:"neuron differentiation") + p(HGNC:MME) increases bp(GO:behavior) - pmid:24590577 + pmid:28250274 - p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") + p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) - pmid:24590577 + pmid:24653673 - act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") + p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) - pmid:24590577 + pmid:24653673 - act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") + p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) - pmid:24590577 + pmid:30640040 - act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) + p(HGNC:EGFR) association a(PUBCHEM:24756910) - pmid:24590577 + pmid:26195256 - p(HGNC:CHRM1) regulates p(HGNC:BACE1) + p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:26195256 - act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") + p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Nephritis, Interstitial"), toLoc(MESH:Brain)) - pmid:24590577 + pmid:26195256 - act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) + p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") + p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - pmid:24590577 + pmid:29626319 - act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:29626319 - act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") + p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) - - - pmid:24590577 - - act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") - + - - - pmid:24590577 - - act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) - + - - - pmid:24590577 - - act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") - + - pmid:18986241 + pmid:21214928 - p(HGNC:CHRM1) association path(MESH:D060825) + complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061) - pmid:18986241 + pmid:22122372 - p(HGNC:CHRM1) association path(MESH:D024801) + bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph)) - pmid:18986241 + pmid:22122372 - p(HGNC:CHRM1) association path(MESH:D000686) + bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") - pmid:26813123 + pmid:28420982 - p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") - pmid:26813123 + pmid:19363271 - act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") + bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) - pmid:24590577 + pmid:23531502 - p(HGNC:CHRM2) association a(MESH:Hippocampus) + bp(GO:"neurofibrillary tangle assembly") positiveCorrelation act(a(CHEBI:"hydrogen peroxide")) - pmid:24590577 + pmid:26655600 - p(HGNC:CHRM2) association a(MESH:Neocortex) + bp(GO:"neurofibrillary tangle assembly") negativeCorrelation p(HBP:"3R tau") - pmid:24590577 + pmid:17050703 - p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) + bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:24590577 + pmid:16816118 - p(HGNC:CHRM3) association a(MESH:Hypothalamus) + bp(GO:"neurofibrillary tangle assembly") negativeCorrelation act(p(HBP:"20 S Proteasome")) - pmid:24590577 + pmid:22122372 - p(HGNC:CHRM3) association a(MESH:Hippocampus) + a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid") - pmid:24511233 + pmid:21718217 - p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") + a(HBP:HBP00038) increases p(HGNC:CCL2) - pmid:24511233 + pmid:21718217 - p(HGNC:CHRM4) association a(MESH:Hippocampus) + a(HBP:HBP00038) increases bp(GO:"microglial cell activation") - pmid:24511233 + pmid:21718217 - p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") + act(a(HBP:HBP00038)) increases bp(GO:phagocytosis) - pmid:24590577 + pmid:28019679 - p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") + a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:24511233 + pmid:24561250 - p(HGNC:CHRM4) association a(MESH:Neocortex) + a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:24511233 + pmid:21718217 - p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") + a(HBP:HBP00022) decreases bp(GO:"synaptic signaling") - pmid:24511233 + pmid:21718217 - act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") + a(HBP:HBP00022) increases bp(GO:"neuron death") - - - pmid:24590577 - - p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") - + - pmid:24590577 + pmid:21214928 - p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") + complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061) - pmid:24590577 + pmid:19721446 - p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) + p(HGNC:DNM1) association p(HGNC:CHRNB2) - pmid:24590577 + pmid:29590627 - p(HGNC:CHRM5) association a(MESH:"Pars Compacta") + act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:24590577 + pmid:29590627 - p(HGNC:CHRM5) increases bp(GO:"response to drug") + act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:24590577 + pmid:29590627 - p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) + act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:24590577 + pmid:21214928 - p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) + a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") @@ -44302,49 +45105,45 @@

Statements

- pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) - pmid:26088141 + pmid:21214928 - p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) - - - - - pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) @@ -44355,40 +45154,45 @@

Statements

- pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067) - + + + pmid:21214928 + + complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + - pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") + complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") - pmid:26088141 + pmid:21214928 - p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) + complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) @@ -44399,846 +45203,905 @@

Statements

- pmid:24511233 + pmid:21214928 - complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") + complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:17009926 + pmid:21214928 - path(MESH:Depression) association p(FPLX:CHRN) + complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067) - pmid:11230871 + pmid:21214928 - path(MESH:Depression) association p(FPLX:CHRN) + complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067)) - pmid:26813123 + pmid:21214928 - path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") - pmid:21482353 + pmid:21214928 - path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") + complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) - pmid:19721446 + pmid:21214928 - path(MESH:Depression) increases a(CHEBI:choline) + p(HGNC:RAB6A) association bp(HBP:HBP00073) - pmid:28901280 + pmid:21214928 - path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") + bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) - pmid:27314526 + pmid:26751493 - bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) + bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) - pmid:24511233 + pmid:26751493 - a(MESH:"Cerebral Cortex") association bp(GO:cognition) + bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:24511233 + pmid:27260836 - a(MESH:"Cerebral Cortex") association bp(GO:learning) + bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + + + + - pmid:24511233 + pmid:21214928 - a(MESH:"Cerebral Cortex") association bp(GO:learning) + complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) + + + + + + + + - pmid:24511233 + pmid:21214928 - a(MESH:"Cerebral Cortex") association bp(GO:memory) + complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) + + - pmid:24511233 + pmid:21214928 - a(MESH:"Cerebral Cortex") association bp(GO:memory) + complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta") + + + + - pmid:24590577 + pmid:21214928 - a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) + complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta") - pmid:26195256 + pmid:21214928 - a(MESH:"Cerebral Cortex") association path(MESH:"Alzheimer Disease") + complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067)) - pmid:24511233 + pmid:21214928 - a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) + a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:19293145 - a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") + a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) - pmid:24511233 + pmid:11230871 - a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") + a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) - pmid:24511233 + pmid:21214928 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:estrogen) increases sec(a(HBP:HBP00067)) - pmid:24511233 + pmid:19293145 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) + a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4")) - pmid:24511233 + pmid:11230871 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") + a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") - pmid:24511233 + pmid:21214928 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") + act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) - pmid:24511233 + pmid:21214928 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") + p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) - pmid:17009926 + pmid:21214928 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") + p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") - pmid:17009926 + pmid:21214928 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) + p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) - pmid:17009926 + pmid:22122372 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:17009926 + pmid:22122372 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) + p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) - pmid:24511233 + pmid:22122372 - path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") + p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) - pmid:24511233 + pmid:21214928 - a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta") - pmid:24590577 + pmid:21214928 - a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") - pmid:24511233 + pmid:21214928 - a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + a(CHEBI:testosterone) decreases r(HGNC:BACE1) - pmid:24511233 + pmid:21214928 - a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) + a(CHEBI:testosterone) decreases p(HGNC:BACE1) - pmid:24590577 + pmid:21214928 - a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) - pmid:29626319 + pmid:21214928 - a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta") + a(CHEBI:testosterone) decreases p(HGNC:PSEN1) - pmid:29626319 + pmid:22122372 - a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:22122372 - a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + a(HBP:HBP00078) association p(HGNC:APP) - pmid:24511233 + pmid:22122372 - path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) + a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) - pmid:24511233 + pmid:22122372 - path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) + a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) - pmid:24511233 + pmid:22122372 - path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) + a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) - pmid:24511233 + pmid:22122372 - path(MESH:Attention) association path(MESH:Schizophrenia) + a(HBP:HBP00079) association p(HGNC:APP) - - - pmid:17009926 - - path(MESH:Attention) association p(FPLX:CHRN) - + + + - pmid:26813123 + pmid:22122372 - path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") + a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:24590577 - - path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - + + + - pmid:25514383 + pmid:22122372 - path(MESH:Attention) association a(HP:"cholinergic neuron") + composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") - - - pmid:24511233 - - path(MESH:"Executive Function") association path(MESH:Schizophrenia) - + - - - pmid:24511233 - - a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) - + - - - pmid:24511233 - - a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) - + - pmid:24511233 + pmid:29221819 - bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) + p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) - - - pmid:26813123 - - bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) - + - - - pmid:26813123 - - bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration) - + - - - pmid:24511233 - - bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) - + - - - pmid:24511233 - - a(CHEBI:xanomeline) increases bp(GO:cognition) - + + + + + + + + + - pmid:26813123 + pmid:22122372 - a(CHEBI:xanomeline) increases bp(GO:cognition) + p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) - pmid:24590577 + pmid:29758300 - a(CHEBI:xanomeline) increases bp(GO:cognition) + p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") - pmid:24511233 + pmid:22908190 - a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) + p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:26813123 + pmid:29758300 - a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) + p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) - pmid:24511233 + pmid:14556719 - a(CHEBI:xanomeline) decreases path(MESH:Delusions) + p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) - pmid:24511233 + pmid:14556719 - a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) + p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta") - pmid:24511233 + pmid:22908190 - a(CHEBI:xanomeline) increases bp(GO:learning) + p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") - pmid:24511233 + pmid:22908190 - a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") + p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites)) - pmid:24511233 + pmid:22908190 - a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") + p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") - pmid:26813123 + pmid:22908190 - a(CHEBI:xanomeline) increases bp(GO:memory) + p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) - pmid:24590577 + pmid:22122372 - a(CHEBI:xanomeline) increases bp(GO:memory) + p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) - pmid:26813123 + pmid:14556719 - a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") + p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) - pmid:26813123 + pmid:14556719 - a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") + p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") + + + + + + + + + + - pmid:24590577 + pmid:22122372 - a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") + a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) + + + + - pmid:24590577 + pmid:22122372 - a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) + complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) + + + + - pmid:24590577 + pmid:22122372 - a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) + complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) + + + + - pmid:24511233 + pmid:22122372 - act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) + complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) - pmid:24511233 + pmid:22122372 - p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta")) + complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) - pmid:24590577 + pmid:22122372 - p(MGI:Chrm1) increases bp(GO:cognition) + complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) + + + + + + + + + + + + - pmid:24590577 + pmid:22122372 - p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") + complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") - pmid:24590577 + pmid:22122372 - act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing") + complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") + + + + + + - pmid:24590577 + pmid:12428809 - act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") + p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") - pmid:18986241 + pmid:19491104 - act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) + act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) - pmid:24511233 + pmid:19491104 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) + p(HGNC:KLC1) isA complex(GO:"kinesin complex") - pmid:24590577 + pmid:19491104 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) + p(HGNC:KLC1) association p(HGNC:MAPK8IP1) + + + + + + + + + + + + + + + + + + + + - pmid:24590577 + pmid:22122372 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") + complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta") + + + + + + + + - pmid:24511233 + pmid:22122372 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) + p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) - pmid:24590577 + pmid:22122372 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) + p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) - pmid:24590577 + pmid:22122372 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) + p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) - pmid:24511233 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) + p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) - pmid:24590577 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) + p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) - pmid:24511233 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) + p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) - pmid:24511233 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) - pmid:24590577 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) - pmid:24590577 + pmid:22122372 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + + + + + + - pmid:24511233 + pmid:22122372 - act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) - pmid:24511233 + pmid:22122372 - a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) - pmid:24511233 + pmid:22122372 - a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) - pmid:24511233 + pmid:22122372 - a(MESH:VU0357017) increases bp(GO:"behavioral fear response") + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) - pmid:24590577 + pmid:22122372 - a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) - pmid:24590577 + pmid:22122372 - a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) - pmid:24590577 + pmid:22122372 - a(MESH:VU0357017) increases bp(GO:learning) + act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") @@ -45247,11 +46110,13 @@

Statements

+ + - pmid:24511233 + pmid:22122372 - complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) + complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) @@ -45262,144 +46127,162 @@

Statements

- pmid:24511233 + pmid:22122372 - complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) + complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668)) - pmid:24511233 + pmid:22122372 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) + complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073) - pmid:24511233 + pmid:19491104 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") + act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) - pmid:24511233 + pmid:19491104 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) + p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") - pmid:24511233 + pmid:19491104 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") + p(HGNC:MAPK8IP1) association p(HGNC:KLC1) - pmid:24511233 + pmid:27094130 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) + p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711"))) - pmid:24590577 + pmid:27094130 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) + p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713"))) - pmid:24511233 + pmid:22122372 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) + a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) + + + + - pmid:24590577 + pmid:22122372 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") - pmid:24590577 + pmid:22122372 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing") + complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) - pmid:24511233 + pmid:22122372 - a(MESH:"Prefrontal Cortex") association bp(GO:cognition) + complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") + + - pmid:24511233 + pmid:18494933 - a(MESH:"Prefrontal Cortex") association bp(GO:learning) + deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) + + + + + + + + + + + + - pmid:24511233 + pmid:19126755 - a(MESH:"Prefrontal Cortex") association bp(GO:memory) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) - pmid:26195256 + pmid:19126755 - a(MESH:"Prefrontal Cortex") association path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") - pmid:24511233 + pmid:19126755 - a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") - pmid:24511233 + pmid:19126755 - a(HBP:VU0456940) increases act(p(HGNC:CHRM1)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") @@ -45408,25 +46291,35 @@

Statements

pmid:24511233 - a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) - pmid:24511233 + pmid:19721446 - a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) + + + + + + + + + + pmid:24511233 - act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") @@ -45435,25 +46328,25 @@

Statements

pmid:24511233 - act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) - pmid:24511233 + pmid:24590577 - path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") - pmid:24511233 + pmid:24590577 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) @@ -45462,7 +46355,7 @@

Statements

pmid:24590577 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) @@ -45471,25 +46364,25 @@

Statements

pmid:24590577 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) - pmid:24762290 + pmid:24590577 - a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") - pmid:24511233 + pmid:24590577 - a(MESH:Neocortex) association p(HGNC:CHRM4) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") @@ -45498,1169 +46391,1141 @@

Statements

pmid:24590577 - a(MESH:Neocortex) association p(HGNC:CHRM2) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) - pmid:24511233 + pmid:24590577 - a(HBP:VU10010) increases act(a(CHEBI:acetylcholine)) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") - pmid:24511233 + pmid:19126755 - a(HBP:VU10010) increases act(p(HGNC:CHRM4)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") - pmid:24511233 + pmid:19126755 - a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases bp(GO:"response to nicotine") - pmid:29191965 + pmid:19126755 - bp(GO:locomotion) positiveCorrelation a(CHEBI:"methylene blue") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") - pmid:29191965 + pmid:19126755 - bp(GO:locomotion) positiveCorrelation a(PUBCHEM:6475963) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:29191965 + pmid:19721446 - bp(GO:locomotion) positiveCorrelation a(HBP:"Phenylthiazolyl-hydrazide") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:24511233 + pmid:19126755 - a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Attention) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:learning) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:memory) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:memory) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:"developmental process") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Schizophrenia) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Schizophrenia) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") - pmid:21482353 + pmid:19126755 - act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Schizophrenia) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Epilepsy) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Epilepsy) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Epilepsy) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:"Autistic Disorder") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") - pmid:17009926 + pmid:19293145 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta")) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta")) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta") - pmid:11230871 + pmid:19293145 - p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity) - pmid:11230871 + pmid:19293145 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) - pmid:26472524 + pmid:19293145 - act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium")) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) - pmid:26472524 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) - pmid:26472524 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) - pmid:26472524 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta")) - pmid:26472524 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") - pmid:17009926 + pmid:19293145 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:17009926 + pmid:24511233 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) - pmid:17009926 + pmid:19721446 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) - pmid:26472524 + pmid:19721446 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") - pmid:17009926 + pmid:19721446 - act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") - pmid:26472524 + pmid:19721446 - p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine)) - pmid:26472524 + pmid:19721446 - p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin)) - pmid:25514383 + pmid:19721446 - act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)")) - pmid:17009926 + pmid:19721446 - act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) - pmid:17009926 + pmid:19721446 - p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") - pmid:26472524 + pmid:19126755 - act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) + a(TAXONOMY:41956) increases a(CHEBI:Muscarine) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) + a(TAXONOMY:33113) increases a(CHEBI:atropine) - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") + a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") + a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") + a(CHEBI:atropine) decreases bp(GO:"cell adhesion") - pmid:17009926 + pmid:26813123 - p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") + a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) - pmid:17009926 + pmid:26751493 - p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") + p(FPLX:PLC) association p(HBP:"projection domain") - pmid:17009926 + pmid:26751493 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") + p(FPLX:PLC) association a(HBP:"projection domain") - pmid:17009926 + pmid:29626319 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") + a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) - pmid:17009926 + pmid:29758300 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") + a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:"Parkinson Disease") + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:"response to pain") + a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:17009926 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Anxiety) + a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Anxiety) + a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:17009926 + pmid:19293145 - p(FPLX:CHRN) association path(MESH:Depression) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:11230871 + pmid:19293145 - p(FPLX:CHRN) association path(MESH:Depression) + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:17009926 + pmid:19721446 - act(p(FPLX:CHRN)) increases path(MESH:Arousal) + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28445721 + pmid:19721446 - p(FPLX:CHRN) association path(MESH:Arousal) + act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:17009926 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") + a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) - pmid:26472524 + pmid:19126755 - p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:nicotine) association path(HBP:neurotoxicity) - pmid:26472524 + pmid:19293145 - p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:nicotine) decreases path(HBP:neurotoxicity) - pmid:26472524 + pmid:19126755 - p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") - pmid:26472524 + pmid:19126755 - p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") - pmid:26813123 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:cognition) + a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") - pmid:25514383 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:cognition) + a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:28445721 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:cognition) + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) - pmid:28445721 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:cognition) + a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") - pmid:28445721 + pmid:18174175 - p(FPLX:CHRN) association bp(GO:cognition) + a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association bp(GO:cognition) + a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR") - pmid:26813123 + pmid:19126755 - p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration) + a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) - - - pmid:25514383 + pmid:19126755 - p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) - - - - - - - - - - - - - - - - - - - - - - - pmid:25514383 + pmid:19293145 - p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") + a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) - pmid:25514383 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") + a(CHEBI:nicotine) increases act(p(FPLX:PKA)) - pmid:25514383 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") + a(CHEBI:nicotine) increases act(p(FPLX:PKC)) - pmid:25514383 + pmid:19126755 - act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") + a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) - pmid:25514383 + pmid:19126755 - p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") + act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB)) - pmid:28445721 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:Motivation) + act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2)) - pmid:28445721 + pmid:19126755 - act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) + act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1)) - pmid:28445721 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") + act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3)) - pmid:28445721 + pmid:19293145 - p(FPLX:CHRN) increases bp(GO:"dopamine secretion") + act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3)) - pmid:28445721 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") + act(a(CHEBI:nicotine)) association a(MESH:Skin) - pmid:21482353 + pmid:19126755 - act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") + act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") - - - pmid:21482353 + pmid:23178521 - p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") - pmid:11230871 + pmid:19126755 - act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") - pmid:21482353 + pmid:19126755 - act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) + a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") - pmid:21482353 + pmid:19126755 - surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) + a(CHEBI:nicotine) decreases sec(p(HGNC:TNF)) - pmid:21482353 + pmid:19293145 - p(FPLX:CHRN) regulates p(HGNC:LYNX1) + a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) - pmid:21482353 + pmid:19126755 - act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) + act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") - pmid:21482353 + pmid:19126755 - act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) + a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:19126755 - p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") + a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) - pmid:21482353 + pmid:19126755 - p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) + a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398")) - pmid:21482353 + pmid:19126755 - p(FPLX:CHRN) increases act(p(FPLX:NOS)) + a(CHEBI:nicotine) decreases bp(GO:"neuron death") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") + a(CHEBI:nicotine) decreases bp(GO:"neuron death") - pmid:11230871 + pmid:19126755 - p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") + a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) - pmid:11230871 + pmid:17009926 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") + a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine)) - pmid:11230871 + pmid:21482353 - p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) + a(CHEBI:nicotine) decreases a(CHEBI:dopamine) - pmid:11230871 + pmid:21482353 - p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") + a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) - pmid:11230871 + pmid:19721446 - p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine)) - pmid:11230871 + pmid:28391535 - p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") + a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) - - - pmid:21787755 + pmid:28391535 - p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") + a(CHEBI:nicotine) increases act(a(CHEBI:dopamine)) - pmid:21787755 + pmid:19126755 - p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") + a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") - pmid:28445721 + pmid:19126755 - bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) + a(CHEBI:nicotine) increases path(MESH:Craving) - pmid:21787755 + pmid:19126755 - bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") + a(CHEBI:nicotine) increases path(MESH:Anxiety) - pmid:17009926 + pmid:19126755 - bp(GO:"developmental process") association p(FPLX:CHRN) + a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) - pmid:17009926 + pmid:19293145 - path(MESH:Epilepsy) association p(FPLX:CHRN) + act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7) @@ -46669,403 +47534,403 @@

Statements

pmid:17009926 - path(MESH:Epilepsy) association p(FPLX:CHRN) + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - pmid:11230871 + pmid:26472524 - path(MESH:Epilepsy) association p(FPLX:CHRN) + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - pmid:21482353 + pmid:19126755 - path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) + a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR") - pmid:21482353 + pmid:19293145 - path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) + a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) - pmid:21787755 + pmid:19293145 - path(MESH:Epilepsy) association a(HBP:AβOs) + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - pmid:28901280 + pmid:19293145 - path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - pmid:17009926 + pmid:19293145 - path(MESH:"Autistic Disorder") association p(FPLX:CHRN) + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - pmid:17009926 + pmid:19293145 - path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) + a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) - pmid:17009926 + pmid:19721446 - path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) + a(CHEBI:nicotine) association bp(MESH:Neuroprotection) - pmid:26472524 + pmid:19293145 - tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") + a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) - pmid:17009926 + pmid:19293145 - p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:17009926 + pmid:19293145 - p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) - pmid:17009926 + pmid:19293145 - p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) - pmid:17009926 + pmid:19293145 - p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") - - - - - - - - - - - pmid:17009926 + pmid:19293145 - composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) + act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph)) - pmid:17009926 + pmid:19293145 - a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) + act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) - + + + pmid:19293145 + + act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) + - pmid:17009926 + pmid:19293145 - composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) + a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph)) - + + + pmid:19293145 + + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + - pmid:17009926 + pmid:19293145 - composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") - pmid:17009926 + pmid:25514383 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") - pmid:28132910 + pmid:19293145 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) + a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) - pmid:28132910 + pmid:19293145 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + a(CHEBI:nicotine) increases act(p(HGNC:BAD)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine)) + a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine)) + act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph)) - pmid:17009926 + pmid:23178521 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline)) + a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin)) + act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)")) + act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid")) + act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) + a(CHEBI:nicotine) increases act(g(HGNC:NIN)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) + a(CHEBI:nicotine) increases act(g(HGNC:PTGS2)) - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) + a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)") - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) + a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:17009926 + pmid:19293145 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) + a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") - pmid:19323834 + pmid:19293145 - a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) + act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) - pmid:17009926 + pmid:19293145 - a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) + a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) - pmid:17009926 + pmid:19293145 - bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) + a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) - pmid:17009926 + pmid:19293145 - act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") + a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") - pmid:17009926 + pmid:19293145 - bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") - pmid:17009926 + pmid:19293145 - bp(GO:"action potential") increases sec(a(CHEBI:dopamine)) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") - pmid:17009926 + pmid:19293145 - path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) + a(CHEBI:nicotine) association p(FPLX:ERK) - pmid:17009926 + pmid:19293145 - path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) + act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) - pmid:27075649 + pmid:19293145 - path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016) + a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") - pmid:17009926 + pmid:19293145 - bp(GO:"response to pain") association p(FPLX:CHRN) + a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta")) - pmid:17009926 + pmid:19293145 - a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) + a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma") @@ -47074,79 +47939,79 @@

Statements

pmid:17009926 - a(PUBCHEM:5311278) decreases bp(GO:memory) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:25514383 + pmid:17009926 - a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:26813123 + pmid:28445721 - p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") + a(CHEBI:nicotine) regulates p(FPLX:CHRN) - pmid:26813123 + pmid:21482353 - p(FPLX:CHRM) regulates a(MESH:"Ion Channels") + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:26813123 + pmid:21482353 - p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) + a(CHEBI:nicotine) increases p(FPLX:CHRN) - pmid:26813123 + pmid:21482353 - p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) + a(CHEBI:nicotine) increases p(FPLX:CHRN) - pmid:26813123 + pmid:21482353 - act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) + a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) - pmid:26813123 + pmid:21787755 - p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:26813123 + pmid:17009926 - act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") + a(CHEBI:nicotine) increases bp(GO:memory) @@ -47155,25 +48020,25 @@

Statements

pmid:25514383 - p(FPLX:CHRM) regulates bp(GO:cognition) + a(CHEBI:nicotine) increases bp(GO:memory) - pmid:17009926 + pmid:11230871 - p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) + a(CHEBI:nicotine) increases bp(GO:memory) - pmid:17009926 + pmid:11230871 - g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + a(CHEBI:nicotine) increases bp(GO:memory) @@ -47182,637 +48047,655 @@

Statements

pmid:17009926 - path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) + a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") - pmid:17009926 + pmid:26813123 - path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) + a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:17009926 + pmid:21958873 - g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:28445721 + pmid:28391535 - path(MESH:Arousal) association p(FPLX:CHRN) + a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:28901280 + pmid:25514383 - path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:23702978 + pmid:25514383 - a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:23702978 + pmid:25514383 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:23702978 + pmid:25514383 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:23702978 + pmid:25514383 - a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:21958873 - a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) + a(CHEBI:nicotine) causesNoChange a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:25514383 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) + a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:26472524 + pmid:25514383 - act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:26751493 + pmid:25514383 - p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain") + a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - + + + pmid:21482353 + + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + - + + + pmid:21482353 + + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + - pmid:16820021 + pmid:25514383 - a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") + a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) + a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) increases p(RGD:Drd2) + a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) decreases p(RGD:Drd2) + a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) increases p(RGD:Drd3) + a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) decreases p(RGD:Drd3) + a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) decreases path(HBP:"isolation rearing") + a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") - pmid:16820021 + pmid:19721446 - a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") + a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") - pmid:16820021 + pmid:25514383 - a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") + a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") - pmid:16820021 + pmid:21482353 - a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) + a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") - pmid:16820021 + pmid:28445721 - a(MESH:antalarmin) decreases r(RGD:Ntrk2) + a(CHEBI:nicotine) increases surf(p(HBP:HBP00174)) - pmid:16820021 + pmid:28445721 - a(MESH:antalarmin) increases r(RGD:Ntrk2) + a(CHEBI:nicotine) increases a(HBP:HBP00174) - pmid:29807032 + pmid:21482353 - a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") + a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) - pmid:29807032 + pmid:21482353 - a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) + a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) - pmid:29807032 + pmid:21482353 - a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") + a(CHEBI:nicotine) increases bp(GO:cognition) - pmid:23211705 + pmid:19721446 - a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") + a(CHEBI:nicotine) increases bp(GO:cognition) - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) increases a(MESH:Morula) + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) increases a(MESH:Blastocyst) + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:23211705 + pmid:18174175 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR") - pmid:23211705 + pmid:21482353 - a(MESH:antalarmin) regulates p(MGI:Crh) + a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR") - + + + pmid:21482353 + + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + - + + + pmid:21482353 + + a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + - pmid:16820021 + pmid:21482353 - path(HBP:"isolation rearing") increases p(RGD:Drd2) + a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) - pmid:16820021 + pmid:21482353 - path(HBP:"isolation rearing") increases p(RGD:Drd2) + a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) - pmid:16820021 + pmid:21482353 - path(HBP:"isolation rearing") increases p(RGD:Drd3) + a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) - pmid:16820021 + pmid:21482353 - path(HBP:"isolation rearing") increases p(RGD:Drd3) + a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:16820021 + pmid:11230871 - path(HBP:"isolation rearing") decreases r(RGD:Bdnf) + a(CHEBI:nicotine) increases bp(GO:learning) - pmid:16820021 + pmid:11230871 - path(HBP:"isolation rearing") increases r(RGD:Bdnf) + a(CHEBI:nicotine) increases path(MESH:Attention) - pmid:16820021 + pmid:19721446 - path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) + a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") - pmid:16820021 + pmid:19721446 - path(HBP:"isolation rearing") increases r(RGD:Ntrk2) + act(a(CHEBI:nicotine)) association p(HGNC:CHRNB4) - pmid:11230871 + pmid:19721446 - a(CHEBI:neurotransmitter) association bp(GO:cognition) + act(a(CHEBI:nicotine)) association p(HGNC:CHRNA2) - pmid:14556719 + pmid:19721446 - sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) + act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5) - pmid:26813123 + pmid:19721446 - bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") + act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) - pmid:26813123 + pmid:22040696 - bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) + a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) - pmid:24563850 + pmid:18174175 - bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") + a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") - pmid:24563850 + pmid:21958873 - bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph)) + a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-beta")) - pmid:24563850 + pmid:21958873 - bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) + a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-alpha")) - pmid:24563850 + pmid:21958873 - bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript)) + a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) - pmid:26813123 + pmid:23178521 - bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB)) - pmid:26813123 + pmid:28391535 - bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands")) - pmid:26813123 + pmid:28391535 - bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:nicotine) increases sec(a(CHEBI:adrenaline)) - pmid:21482353 + pmid:28391535 - bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:nicotine) decreases sec(a(CHEBI:"insulin (human)")) - pmid:24590577 + pmid:28391535 - bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:26813123 + pmid:28391535 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:26813123 + pmid:28391535 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity") - pmid:26813123 + pmid:28391535 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"Receptors, Nicotinic")) - - - pmid:26813123 + pmid:28391535 - bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) + a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine)) - pmid:26813123 + pmid:28391535 - p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT)) + act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium) - pmid:26813123 + pmid:19126755 - a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) + a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26813123 + pmid:19126755 - a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:26813123 + pmid:19126755 - p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") + a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:26813123 + pmid:19126755 - p(MGI:Slc18a3) increases bp(GO:cognition) + a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:26813123 + pmid:21482353 - a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) + a(HBP:"alpha-Bungarotoxin") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:26813123 + pmid:19126755 - a(CHEBI:antidote) increases act(p(HGNC:ACHE)) + bp(GO:signaling) association a(CHEBI:acetylcholine) - pmid:26813123 + pmid:19126755 - a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) + act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) @@ -47821,29 +48704,27 @@

Statements

pmid:26813123 - a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) + p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) - pmid:26813123 + pmid:19293145 - p(MGI:Slc5a7) decreases path(MESH:Death) + p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) - - pmid:26813123 - complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") + act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") @@ -47852,60 +48733,61 @@

Statements

pmid:26813123 - a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHAT)) decreases path(MESH:Dementia) - pmid:26813123 + pmid:16273023 - p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN)) + act(p(HGNC:CHAT), ma(cat)) increases a(CHEBI:acetylcholine) - pmid:26813123 + pmid:24590577 - a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph)) + p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) - - - - - pmid:26813123 + pmid:25514383 - complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) - + + + pmid:18986241 + + act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) + - pmid:26813123 + pmid:19721446 - complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + p(HGNC:CHAT) increases a(CHEBI:acetylcholine) - pmid:22020111 + pmid:18986241 - a(CHEBI:cystine) increases a(CHEBI:glutathione) + act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration) @@ -47914,20 +48796,22 @@

Statements

+ + - pmid:26813123 + pmid:28002468 - complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation") - pmid:11230871 + pmid:17009926 - complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) + a(CHEBI:choline) increases act(p(FPLX:CHRN)) @@ -47936,127 +48820,115 @@

Statements

pmid:26813123 - a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) + a(CHEBI:choline) increases a(CHEBI:acetylcholine) - pmid:29626319 + pmid:26088141 - a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta")) + act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") - - - - - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) - pmid:26813123 + pmid:26088141 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) + a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) - - - - - pmid:26813123 + pmid:21482353 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:26813123 + pmid:21482353 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR")) - pmid:26813123 + pmid:19721446 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + a(CHEBI:choline) increases bp(MESH:Neuroprotection) - pmid:26813123 + pmid:19721446 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) - - - - pmid:26813123 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") @@ -48065,7 +48937,7 @@

Statements

pmid:26813123 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") @@ -48074,7 +48946,7 @@

Statements

pmid:26813123 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") @@ -48083,29 +48955,25 @@

Statements

pmid:26813123 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") - - - - pmid:26813123 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) + p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") - pmid:26813123 + pmid:19721446 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") + p(HGNC:CHRNA2) association act(a(CHEBI:nicotine)) @@ -48114,440 +48982,460 @@

Statements

pmid:26813123 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) + p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") - - - pmid:26813123 + pmid:11230871 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) + p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26813123 + pmid:11230871 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") + p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26813123 + pmid:19721446 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) + p(HGNC:CHRNA3) association path(MESH:Craving) + + + pmid:19721446 + + p(HGNC:CHRNA3) association path(MESH:Recurrence) + + - pmid:26088141 + pmid:19126755 - act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) + p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pmid:11230871 - act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") + p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") - + + + pmid:19126755 + + p(HGNC:CHRNA4) association p(HGNC:PTGS2) + - pmid:26813123 + pmid:19293145 - complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) + p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:26813123 + pmid:17009926 - a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) + p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:26813123 + pmid:19293145 - a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) + act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:25514383 + pmid:19293145 - a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) + act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) - pmid:26813123 + pmid:19721446 - path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) - pmid:26813123 + pmid:19293145 - p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") - pmid:24590577 + pmid:23038257 - p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) + p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") - pmid:24590577 + pmid:23038257 - p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") + p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") - pmid:24590577 + pmid:17009926 - p(MGI:Chrm4) decreases act(p(MGI:Drd1)) + p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + pmid:26813123 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") + p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") + + - pmid:22020111 + pmid:11230871 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates") + p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) + + - pmid:29758300 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) + p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") - pmid:29758300 + pmid:26813123 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) + p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") + + - pmid:14556719 + pmid:19721446 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") + p(HGNC:CHRNA5) association act(a(CHEBI:nicotine)) - pmid:14556719 + pmid:26813123 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") + p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") - pmid:14556719 + pmid:21787755 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") + p(HGNC:CHRNA6) association path(MESH:Reward) - pmid:14556719 + pmid:21787755 - path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) + p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") - pmid:14556719 + pmid:21787755 - path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") + p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) - pmid:14556719 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) + p(HGNC:CHRNA7) association a(MESH:Neurons) - pmid:14556719 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) - pmid:14556719 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) - pmid:22908190 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) + + - pmid:22908190 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") - pmid:25784053 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) + act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") - pmid:25784053 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:30116051 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:30116051 + pmid:19293145 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") - pmid:30116051 + pmid:22040696 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) + p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) - pmid:30116051 + pmid:19126755 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) + act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") - pmid:26813123 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") + act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:29758300 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) + act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) - pmid:30126037 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) + p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) - pmid:30126037 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045) + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) - pmid:30126037 + pmid:17009926 - path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") + act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) - pmid:30126037 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) + p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) - pmid:30126037 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) + act(p(HGNC:CHRNA7)) association bp(GO:cognition) - pmid:30126037 + pmid:19721446 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") + p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) - pmid:30126037 + pmid:19721446 - path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") + act(p(HGNC:CHRNA7)) increases bp(GO:cognition) - pmid:30126037 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29311797 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) + p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:11230871 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:22040696 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") @@ -48556,304 +49444,306 @@

Statements

pmid:29191965 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) + p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) + act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:28420982 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") + act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:26631930 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") + act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:26751493 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") + act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") - pmid:26631930 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") + act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:26631930 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132) + p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:26631930 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) + p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta")) - pmid:26631930 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta") - pmid:12578227 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) + p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta") - pmid:12578227 + pmid:17009926 - path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) + p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:12578227 + pmid:29191965 - path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)") + p(HGNC:CHRNA7) regulates act(a(CHEBI:"amyloid-beta")) - pmid:12578227 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) + act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) - pmid:11089576 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") - pmid:22057784 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) - pmid:17050703 + pmid:19126755 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) - pmid:29281045 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) + p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) - pmid:29281045 + pmid:19293145 - path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89") + p(HGNC:CHRNA7) increases a(CHEBI:nicotine) - pmid:26813123 + pmid:19126755 - path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") + p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") - pmid:26813123 + pmid:19293145 - act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers") + p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") - pmid:26813123 + pmid:19293145 - a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) - pmid:25514383 + pmid:19293145 - a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) - pmid:28445721 + pmid:19293145 - act(a(GO:synapse)) regulates p(FPLX:CHRN) + act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") + act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium")) - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) + + - pmid:22908190 + pmid:19293145 - act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) + act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) - pmid:26631930 + pmid:19293145 - act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) + p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") - pmid:26631930 + pmid:19293145 - act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) + p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") - pmid:27807169 + pmid:19293145 - a(GO:synapse) positiveCorrelation p(RGD:Cdk5r2) + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") - pmid:22156579 + pmid:19293145 - a(GO:synapse) negativeCorrelation p(HGNC:MARK4) + act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") - pmid:26813123 + pmid:19293145 - p(HGNC:SYP) association bp(GO:memory) + p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) @@ -48862,65 +49752,62 @@

Statements

- - - pmid:26813123 - - complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils") - + + + - pmid:26813123 + pmid:17009926 - p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") - pmid:26813123 + pmid:22040696 - p(MGI:App, var("?")) decreases p(FPLX:CHRM) + p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") - pmid:26813123 + pmid:17009926 - p(MGI:App, var("?")) decreases p(FPLX:CHRN) + p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:26813123 + pmid:17009926 - a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) + act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") - pmid:26813123 + pmid:17009926 - a(PUBCHEM:10013505) increases bp(GO:cognition) + p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates") - pmid:26813123 + pmid:17009926 - a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) @@ -48929,1249 +49816,1292 @@

Statements

pmid:26813123 - a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) + p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") - pmid:26813123 + pmid:26088141 - a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") + p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly") + + - pmid:24653673 + pmid:26088141 - p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) - pmid:30116051 + pmid:26088141 - p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) + p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) - pmid:30116051 + pmid:26088141 - p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") + p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) - pmid:29215007 + pmid:18986241 - p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) - pmid:29988016 + pmid:18986241 - p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) - - - pmid:21882945 - - p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") - + + + - pmid:26631930 + pmid:19721446 - p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) association a(MESH:Hippocampus) - pmid:21882945 + pmid:19721446 - p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:CHRNA7) association bp(GO:memory) - pmid:26631930 + pmid:19721446 - p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + act(p(HGNC:CHRNA7)) decreases bp(GO:memory) - pmid:26631930 + pmid:19721446 - p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) + p(HGNC:CHRNA7) association bp(GO:learning) - pmid:26813123 + pmid:19721446 - a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) - pmid:26813123 + pmid:19721446 - a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) + act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) - pmid:26813123 + pmid:19721446 - a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) + p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") - pmid:26813123 + pmid:19721446 - a(PUBCHEM:9867750) increases bp(GO:cognition) + p(HGNC:CHRNA7) association a(CHEBI:clozapine) - pmid:26813123 + pmid:22040696 - a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") + p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") - pmid:26813123 + pmid:22040696 - a(PUBCHEM:1476756) increases bp(GO:memory) + p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") - pmid:24027553 + pmid:22040696 - a(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) + p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") + + - pmid:25899010 + pmid:22040696 - a(HBP:Excitotoxicity) positiveCorrelation p(HGNC:DAPK1) + p(HGNC:CHRNA7) association p(HGNC:BDNF) - pmid:26813123 + pmid:22040696 - a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") + tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) - - - pmid:26813123 - - a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") - + + + - pmid:26813123 + pmid:22040696 - a(MESH:"Nerve Growth Factor") increases bp(GO:memory) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) - pmid:11230871 + pmid:22040696 - a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) + p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") - pmid:16273023 + pmid:22040696 - path(MESH:D000544) association path(MESH:D016874) + p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") - pmid:18986241 + pmid:22040696 - path(MESH:D000544) increases path(MESH:D016874) + p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") - pmid:16273023 + pmid:28901280 - path(MESH:D000544) association path(MESH:D058225) + p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") - pmid:16273023 + pmid:28901280 - path(MESH:D000544) association bp(GO:"GO:0070997") + p(HGNC:CHRNA7) regulates path(MESH:Inflammation) - pmid:16273023 + pmid:28901280 - path(MESH:D000544) decreases bp(MESH:D009435) + p(HGNC:CHRNA7) association path(MESH:Neoplasms) - pmid:16273023 + pmid:28901280 - path(MESH:D000544) decreases bp(GO:"GO:0007271") + p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") - pmid:16273023 + pmid:28901280 - path(MESH:D000544) decreases bp(GO:"GO:0035249") + p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") - pmid:16273023 + pmid:29191965 - path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat)) + p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") - pmid:18986241 + pmid:29191965 - path(MESH:D000544) decreases p(HGNC:CHAT) + p(HGNC:CHRNA7) regulates act(a(GO:synapse)) - pmid:16273023 + pmid:29191965 - path(MESH:D000544) decreases bp(GO:"GO:0015871") + p(HGNC:CHRNA7) association path(MESH:Tauopathies) - pmid:16273023 + pmid:26813123 - path(MESH:D000544) decreases bp(GO:"GO:0008292") + p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") - pmid:16273023 + pmid:28901280 - path(MESH:D000544) causesNoChange p(MESH:D011950) + p(HGNC:CHRNA9) increases path(MESH:Neoplasms) - pmid:16273023 + pmid:26813123 - path(MESH:D000544) decreases bp(GO:"GO:0051935") + p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") - pmid:16273023 + pmid:17009926 - path(MESH:D000544) decreases bp(GO:"GO:0014047") + act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") - pmid:16273023 + pmid:26813123 - path(MESH:D000544) decreases bp(GO:"GO:0014047") + p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") + + - pmid:16273023 + pmid:19721446 - path(MESH:D000544) decreases bp(MESH:D017774) + p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) - pmid:16273023 + pmid:19721446 - path(MESH:D000544) decreases bp(MESH:D017774) + p(HGNC:CHRNB2) association p(HGNC:DNM1) - pmid:16273023 + pmid:19721446 - path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) + p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") - pmid:18986241 + pmid:19721446 - path(MESH:D000544) association path(MESH:D019636) + p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) - pmid:18986241 + pmid:26813123 - path(MESH:D000544) association path(MESH:D008568) + p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) association path(MESH:D003071) + p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") - pmid:18986241 + pmid:26813123 - path(MESH:D000544) association path(MESH:D001526) + p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") + + - pmid:18986241 + pmid:19721446 - path(MESH:D000544) association path(HBP:aMCI) + p(HGNC:CHRNB4) association act(a(CHEBI:nicotine)) - pmid:18986241 + pmid:19721446 - path(MESH:D000544) decreases a(MESH:D059329) + p(HGNC:CHRNB4) association path(MESH:Craving) - pmid:18986241 + pmid:19721446 - path(MESH:D000544) association a(MESH:D059329) + p(HGNC:CHRNB4) association path(MESH:Recurrence) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases a(MESH:D059329) + p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) association a(MESH:D016874) + p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases p(HGNC:ACHE) + p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) causesNoChange act(p(HGNC:ACHE)) + p(HBP:"alpha-4 beta-2 nAChR") increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases act(p(HGNC:ACHE)) + act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases act(p(HGNC:ACHE)) + act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) increases act(p(HGNC:BCHE)) + act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) causesNoChange p(HGNC:SLC18A3) + p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) - pmid:18986241 + pmid:26472524 - path(MESH:D000544) increases path(MESH:D001284) + act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) increases a(MESHC:"pro-nerve growth factor, human") + p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases p(HGNC:NTRK1) + p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") - pmid:18986241 + pmid:26472524 - path(MESH:D000544) increases p(HGNC:NGF) + p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) association p(HGNC:SORT1) + a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases bp(GO:"GO:0032455") + bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) increases act(p(HGNC:MMP9)) + a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases g(HGNC:NTRK1) + a(MESH:Neurons) decreases r(HGNC:CHRNA3) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases g(HGNC:NTRK2) + a(MESH:Neurons) increases r(HGNC:CHRNA4) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases g(HGNC:NTRK3) + a(MESH:Neurons) association p(HGNC:CHRNA7) - pmid:18986241 + pmid:19126755 - path(MESH:D000544) increases g(HGNC:NGFR) + a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") - pmid:18986241 + pmid:21482353 - path(MESH:D000544) causesNoChange r(HGNC:CHAT) + a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) - pmid:18986241 + pmid:21482353 - path(MESH:D000544) increases r(HGNC:CHRNA7) + a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:18986241 + pmid:28901280 - path(MESH:D000544) increases r(HGNC:CHRNA7) + a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") - pmid:18986241 + pmid:27671637 - path(MESH:D000544) causesNoChange r(HGNC:CHRM1) + act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:18986241 + pmid:29238289 - path(MESH:D000544) decreases r(HGNC:SYP) + act(a(MESH:Neurons)) increases p(HGNC:MAPT) - pmid:18986241 + pmid:29238289 - path(MESH:D000544) decreases r(GFAM:Synaptotagmins) + act(a(MESH:Neurons)) increases p(HGNC:MAPT) - pmid:18986241 + pmid:29238289 - path(MESH:D000544) causesNoChange r(HGNC:VAMP1) + a(MESH:Neurons) causesNoChange p(HGNC:MAPT) - pmid:18986241 + pmid:27796283 - path(MESH:D000544) causesNoChange r(HGNC:SNAP29) + act(a(MESH:Neurons)) increases p(HGNC:CAMKV) - pmid:18986241 + pmid:27087442 - path(MESH:D000544) causesNoChange r(HGNC:APP) + act(a(MESH:Neurons)) positiveCorrelation p(MGI:Cdk5r1) - pmid:18986241 + pmid:27087442 - path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) + act(a(MESH:Neurons)) positiveCorrelation act(p(HBP:RAC1b)) - pmid:18986241 + pmid:27087442 - path(MESH:D000544) increases r(HGNC:CTSD) + act(a(MESH:Neurons)) negativeCorrelation p(MGI:Cdk5) - - - pmid:18986241 - - path(MESH:D000544) decreases r(HGNC:PPP1CA) - + + + + + - pmid:18986241 + pmid:19126755 - path(MESH:D000544) decreases r(HGNC:PPP1CC) + complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + - pmid:18986241 + pmid:19126755 - path(MESH:D000544) causesNoChange r(HGNC:MAPT) + complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) - pmid:18986241 + pmid:21787755 - path(MESH:D000544) decreases a(HBP:"3R tau") + a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) - pmid:16273023 + pmid:21787755 - path(MESH:D016874) association path(MESH:D000544) + a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) - pmid:18986241 + pmid:19126755 - path(MESH:D016874) association bp(HBP:hyperphosphorylation) + act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + + + + - pmid:16273023 + pmid:19126755 - path(MESH:D058225) association path(MESH:D000544) + complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) - pmid:18986241 + pmid:19126755 - path(MESH:D058225) association p(HGNC:BCHE) + a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:18986241 + pmid:19126755 - path(MESH:D058225) association p(HGNC:ACHE) + a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0070997") association path(MESH:D000544) + a(MESH:Conotoxins) decreases act(a(MESH:"Voltage-Gated Sodium Channels")) - pmid:16273023 + pmid:19721446 - bp(GO:"GO:0070997") association act(p(MESH:D017470)) + a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:16273023 + pmid:19721446 - bp(GO:"GO:0007271") association path(MESH:D003071) + a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) - pmid:16273023 + pmid:19721446 - bp(GO:"GO:0007271") association path(MESH:D003071) + a(MESH:Conotoxins) decreases path(MESH:Pain) - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0007271") association a(MESH:D002800) + p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0035249") association path(MESH:D003071) + a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") + + + + - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0035249") association path(MESH:D003071) + complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") + a(TAXONOMY:92736) increases a(CHEBI:epibatidine) - pmid:16273023 + pmid:19293145 - bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") + a(CHEBI:epibatidine) causesNoChange bp(GO:memory) - pmid:16273023 + pmid:19293145 - path(MESH:D003071) association bp(GO:"GO:0035249") + a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) - pmid:16273023 + pmid:19293145 - path(MESH:D003071) association bp(GO:"GO:0035249") + a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") - pmid:16273023 + pmid:19293145 - path(MESH:D003071) association bp(GO:"GO:0007271") + a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") - pmid:16273023 + pmid:28132910 - path(MESH:D003071) association bp(GO:"GO:0007271") + a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + + + + - pmid:18986241 + pmid:19126755 - path(MESH:D003071) association path(MESH:D000544) + complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + - pmid:18986241 + pmid:19126755 - path(MESH:D003071) association p(HGNC:BCHE) + complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR")) + + + + - pmid:18986241 + pmid:19126755 - path(MESH:D003071) association g(HGNC:NTRK1) + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) - pmid:18986241 + pmid:19293145 - path(MESH:D003071) association g(HGNC:NTRK2) + a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19293145 - path(MESH:D003071) association g(HGNC:NTRK3) + a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19293145 - path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7) + a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) - pmid:18986241 + pmid:19293145 - path(MESH:D003071) association act(p(HGNC:GAL)) + a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity) - pmid:16273023 + pmid:25881725 - bp(GO:"GO:0008292") association path(MESH:D003704) + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:16273023 + pmid:25881725 - path(MESH:D003704) association bp(GO:"GO:0008292") + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:18986241 + pmid:25881725 - path(MESH:D003704) association path(HBP:aMCI) + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:18986241 + pmid:25881725 - path(MESH:D003704) association a(MESH:D059329) + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:18986241 + pmid:25881725 - path(MESH:D003704) decreases p(HGNC:ACHE) + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:16273023 + pmid:25881725 - path(MESH:D013850) association a(MESH:D006624) + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:16273023 + pmid:25881725 - path(MESH:D013850) association a(MESH:D019579) + a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) - pmid:16273023 + pmid:25881725 - path(MESH:D013850) association a(CHEBI:"glutamate(1-)") + a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) - pmid:16273023 + pmid:25881725 - a(MESH:D006624) association path(MESH:D013850) + a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) - pmid:16273023 + pmid:25881725 - a(MESH:D006624) association path(MESH:D008568) + a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") - pmid:16273023 + pmid:25881725 - a(MESH:D019579) association path(MESH:D013850) + a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) - pmid:16273023 + pmid:19721446 - a(MESH:D019579) association path(MESH:D008568) + a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) + + + + - pmid:16273023 + pmid:19126755 - a(CHEBI:"glutamate(1-)") association path(MESH:D013850) + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) + + + + - pmid:16273023 + pmid:19126755 - a(CHEBI:"glutamate(1-)") association path(MESH:D008568) + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) - pmid:27087442 + pmid:19126755 - a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25") + r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") - pmid:16273023 + pmid:19126755 - path(MESH:D008568) association a(MESH:D006624) + r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") - pmid:16273023 + pmid:21787755 - path(MESH:D008568) association a(MESH:D019579) + r(HGNC:CHRNB4) association r(HGNC:CHRNA4) - pmid:16273023 + pmid:21787755 - path(MESH:D008568) association a(CHEBI:"glutamate(1-)") + r(HGNC:CHRNA4) association r(HGNC:CHRNB4) - pmid:16273023 + pmid:21787755 - path(MESH:D008568) association bp(MESH:D017774) + r(HGNC:CHRNA6) association path(MESH:Reward) - pmid:18986241 + pmid:21787755 - path(MESH:D008568) association path(MESH:D000544) + r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") - pmid:18986241 + pmid:21787755 - path(MESH:D008568) association a(MESH:D059329) + r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) - pmid:16273023 + pmid:19126755 - act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") + a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) - pmid:16273023 + pmid:19126755 - bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") + path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) - pmid:16273023 + pmid:24561250 - bp(GO:"GO:0014047") increases bp(MESH:D017774) + path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") - pmid:16273023 + pmid:24561250 - bp(GO:"GO:0051935") increases a(CHEBI:glutamine) + path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") - pmid:16273023 + pmid:19126755 - a(CHEBI:glutamine) increases bp(GO:"GO:0006868") + a(MESH:Adult) decreases r(HGNC:CHRNA3) - pmid:16273023 + pmid:19126755 - act(p(MESH:D017470)) association bp(GO:"GO:0070997") + a(MESH:Adult) increases r(HGNC:CHRNA4) + + + + + + - pmid:16273023 + pmid:19126755 - bp(MESH:D017774) association path(MESH:D008568) + r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") + + + + - pmid:16273023 + pmid:19126755 - bp(MESH:D017774) association path(MESH:D007858) + act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) - pmid:16273023 + pmid:18494933 - path(MESH:D007858) association bp(MESH:D017774) + p(HGNC:JUN) partOf p(FPLX:AP1) - pmid:16273023 + pmid:19126755 - a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) + act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") @@ -50182,150 +51112,144 @@

Statements

- pmid:16273023 + pmid:19126755 - composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) + composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) - pmid:16273023 + pmid:19126755 - a(MESH:D002800) increases bp(GO:"GO:0014047") + p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) - pmid:16273023 + pmid:19126755 - a(MESH:D002800) increases bp(GO:"GO:0014047") + p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) - - - pmid:16273023 - - a(MESH:D002800) increases a(CHEBI:acetylcholine) - + - pmid:16273023 + pmid:19126755 - a(MESH:D002800) association bp(GO:"GO:0007271") + complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) + + - pmid:18986241 + pmid:19126755 - a(MESH:D002800) decreases path(MESH:D000544) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) + + - pmid:18986241 + pmid:25514383 - a(MESH:D002800) decreases a(CHEBI:"amyloid-beta") + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") - pmid:18986241 + pmid:25514383 - a(MESH:D002800) increases bp(MESH:D000066829) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) + + - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association bp(GO:"GO:0050435") + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) + + - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association path(MESH:D007319) + a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association path(MESH:D003967) + a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association path(MESH:D009325) + a(MESH:Muscles) increases r(HGNC:CHRNA1) - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association path(MESH:D005221) + a(MESH:Muscles) increases r(HGNC:CHRNB1) - pmid:18986241 + pmid:19126755 - a(MESH:D002800) association path(MESH:D000855) + a(MESH:Muscles) increases r(HGNC:CHRND) - - - pmid:16273023 + pmid:19126755 - complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) + a(MESH:Muscles) increases r(HGNC:CHRNG) - - - pmid:16273023 - - a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) - - @@ -50334,616 +51258,571 @@

Statements

- pmid:16273023 + pmid:19126755 - act(p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) - - - - - pmid:24590577 + pmid:19126755 - a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) - pmid:24027553 + pmid:23038257 - a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) - pmid:29758300 + pmid:26813123 - a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) - pmid:23528736 + pmid:19126755 - a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") - pmid:29758300 + pmid:26813123 - a(HBP:"Tau aggregates") association bp(GO:autophagy) + p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") - - - pmid:29758300 - - a(HBP:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) - + - - - pmid:22908190 - - a(HBP:"Tau aggregates") increases p(HBP:"Tau aggregates", pmod(Ub)) - + - pmid:22908190 + pmid:19126755 - a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) - pmid:24027553 + pmid:19126755 - a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) - - - pmid:24027553 - - a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) - + - - - pmid:24027553 - - a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) - + - pmid:27574109 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") + bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) - pmid:29590627 + pmid:19126755 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:29590627 + pmid:17009926 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") - pmid:29590627 + pmid:26472524 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") - pmid:29590627 + pmid:17009926 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") - pmid:29590627 + pmid:19126755 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:26751493 + pmid:19126755 - a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) - - - pmid:26751493 - - tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") - + + + - pmid:29590627 + pmid:19126755 - a(HBP:"Tau aggregates") association a(GO:"early endosome") + composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) - - - pmid:29590627 - - a(HBP:"Tau aggregates") association a(GO:"late endosome") - + + + - pmid:29590627 + pmid:19126755 - a(HBP:"Tau aggregates") association a(GO:lysosome) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - - - pmid:22611162 - - a(HBP:"Tau aggregates") increases path(HBP:proteotoxicity) - + - - - pmid:22611162 - - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") - + - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - - - pmid:22611162 - - a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") - + + + - pmid:22611162 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") + composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG)), p(HGNC:CHRNB1)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - - - pmid:22611162 - - a(HBP:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") - + - - - pmid:22611162 - - a(HBP:"Tau aggregates") decreases p(UNIPROT:O02495) - + - pmid:22611162 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") + a(MESH:Oocytes) association composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) - - - pmid:22611162 - - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") - + + + - pmid:28528849 + pmid:19126755 - a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") + composite(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) - pmid:28528849 + pmid:19126755 - a(HBP:"Tau aggregates") causesNoChange a(GO:membrane) + a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR") - pmid:29988016 + pmid:19126755 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Hippocampus) increases p(HGNC:CHRNA7) - pmid:27373205 + pmid:19721446 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Hippocampus) association p(HGNC:CHRNA7) - pmid:26631930 + pmid:24511233 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Hippocampus) association bp(GO:cognition) - pmid:22817713 + pmid:24511233 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Hippocampus) association bp(GO:learning) - pmid:21882945 + pmid:24511233 - a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) + a(MESH:Hippocampus) association bp(GO:learning) - pmid:29311797 + pmid:24511233 - a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) + a(MESH:Hippocampus) association bp(GO:memory) - pmid:30640040 + pmid:24511233 - a(HBP:"Tau aggregates") increases bp(GO:"cell killing") + a(MESH:Hippocampus) association bp(GO:memory) - pmid:29191965 + pmid:19721446 - a(HBP:"Tau aggregates") decreases act(a(GO:synapse)) + a(MESH:Hippocampus) association bp(GO:memory) - pmid:29191965 + pmid:24511233 - a(HBP:"Tau aggregates") decreases a(GO:presynapse) + a(MESH:Hippocampus) association p(HGNC:CHRM4) - pmid:29191965 + pmid:24590577 - a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + a(MESH:Hippocampus) association p(HGNC:CHRM1) - pmid:25374103 + pmid:24590577 - a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") + a(MESH:Hippocampus) association p(HGNC:CHRM2) - pmid:28420982 + pmid:24590577 - a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") + a(MESH:Hippocampus) association p(HGNC:CHRM3) - pmid:28877763 + pmid:26390242 - a(HBP:"Tau aggregates") association p(HGNC:SYK) + a(MESH:Hippocampus) positiveCorrelation a(CHEBI:salsalate) - pmid:28877763 + pmid:19126755 - a(HBP:"Tau aggregates") association p(HGNC:SYK) + a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-2 nAChR") - pmid:28877763 + pmid:19126755 - a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:SYK) + a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR") - - - pmid:28877763 - - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - + - pmid:28420982 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) - pmid:22817713 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) - pmid:22817713 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") + + - pmid:22817713 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28420982 + pmid:19126755 - a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") + a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + + + + - pmid:28420982 + pmid:19126755 - a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT)) + composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + + + + + + + + - pmid:28420982 + pmid:25514383 - a(HBP:"Tau aggregates") association a(CHEBI:dextran) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR") - pmid:29311797 + pmid:19721446 - a(HBP:"Tau aggregates") association p(HGNC:HDAC6) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") - pmid:29311797 + pmid:19126755 - a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") + p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) + a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly") - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") positiveCorrelation bp(GO:aging) + a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") decreases bp(GO:"microtubule polymerization") + a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") decreases act(a(MESH:Neurons)) + bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) - pmid:26631930 + pmid:19126755 - a(HBP:"Tau aggregates") increases path(HBP:Neurodegeneration) + bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) - pmid:22817713 + pmid:19126755 - a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA)) + a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - pmid:22817713 + pmid:29626319 - a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A)) + a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) - pmid:22817713 + pmid:29626319 - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) - pmid:22817713 + pmid:29626319 - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) @@ -50954,37 +51833,18 @@

Statements

- pmid:25125464 + pmid:21787755 - a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1) + a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) - - - pmid:22908190 - - bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") - + - - - pmid:26631930 - - bp(GO:"axonal transport") decreases path(HBP:Neurodegeneration) - - - - - - - pmid:21734277 - - bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:PPP1CA)) - + @@ -50996,9 +51856,9 @@

Statements

- pmid:24590577 + pmid:19126755 - complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") + composite(a(CHEBI:nicotine), g(HGNC:CHRNA4), g(HGNC:CHRNA6), g(HGNC:CHRNB2), g(HGNC:CHRNB3)) increases composite(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) @@ -51007,1803 +51867,1646 @@

Statements

- - - pmid:24590577 - - complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - + - pmid:24590577 + pmid:19126755 - complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) - - - - - pmid:24590577 + pmid:19293145 - complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) + a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") - pmid:24590577 + pmid:25514383 - complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") - - - - - pmid:24590577 + pmid:25514383 - complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) + act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") - pmid:24590577 + pmid:25514383 - complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction") - - - - - pmid:24590577 + pmid:25514383 - complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") + act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") - pmid:24590577 + pmid:21482353 - complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) - - - - - pmid:24590577 + pmid:21482353 - complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") + a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") - pmid:24590577 + pmid:21482353 - complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") - pmid:24590577 + pmid:19126755 - path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane") - pmid:24590577 + pmid:21482353 - a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) - pmid:29626319 + pmid:21482353 - a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) - pmid:29626319 + pmid:21482353 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:29626319 + pmid:19126755 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") + bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) - pmid:29626319 + pmid:19126755 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) - pmid:29626319 + pmid:26813123 - a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:24590577 + pmid:26813123 - a(MESH:Thalamus) association p(HGNC:CHRM1) + bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:24762290 + pmid:26813123 - a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") + bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) - pmid:24762290 + pmid:26813123 - a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") + bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) - pmid:24590577 + pmid:26813123 - p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") + bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) - pmid:24590577 + pmid:28901280 - a(MESH:Hypothalamus) association p(HGNC:CHRM3) + bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") - pmid:24590577 + pmid:19126755 - p(MGI:Chrm3) regulates bp(GO:"response to food") + act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression") - pmid:24590577 + pmid:19126755 - p(MGI:Chrm3) increases bp(GO:"pituitary gland development") + act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") - pmid:24590577 + pmid:19126755 - p(MGI:Chrm3) increases p(MGI:Prl) + act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") + + - pmid:24590577 + pmid:27550730 - p(MGI:Chrm3) increases p(MGI:Gh) + act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) - pmid:24590577 + pmid:19126755 - p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") + act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") - pmid:24590577 + pmid:19126755 - a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") + act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript)) - pmid:24590577 + pmid:19126755 - a(MESH:"Pars Compacta") association p(HGNC:CHRM5) + complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) - pmid:22020111 + pmid:14556719 - a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) + bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:24653673 + pmid:19126755 - bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) + p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine)) - pmid:24653673 + pmid:19126755 - bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) + p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine)) - pmid:24653673 + pmid:19126755 - bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK)) + bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine)) - pmid:24027553 + pmid:28445721 - bp(HBP:"APP processing") association p(HGNC:HTRA1) + bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) - pmid:24027553 + pmid:19126755 - bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease") + a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") - pmid:24590577 + pmid:21787755 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) + sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) - pmid:24590577 + pmid:21787755 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta") + sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) - pmid:24590577 + pmid:28391535 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:dopamine) regulates path(MESH:Pleasure) - pmid:24590577 + pmid:28391535 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:dopamine) regulates path(MESH:Motivation) - pmid:24590577 + pmid:27075649 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") + a(CHEBI:dopamine) increases a(HBP:HBP00093) - pmid:24590577 + pmid:27075649 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) + a(CHEBI:dopamine) increases a(HBP:HBP00093) - pmid:24590577 + pmid:19126755 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) + a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") - pmid:24590577 + pmid:19293145 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") + act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity) - pmid:24401760 + pmid:17009926 - p(MGI:Bace1) positiveCorrelation a(CHEBI:"amyloid-beta") + sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation") - - - pmid:24590577 + pmid:16273023 - complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) + a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") - - - pmid:29686391 + pmid:16273023 - bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") + a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) - pmid:24590577 + pmid:21482353 - bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) + a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") - pmid:18494933 + pmid:19721446 - bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) - pmid:24590577 + pmid:19721446 - a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) - pmid:24027553 + pmid:19721446 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) - pmid:24027553 + pmid:19721446 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:24027553 + pmid:19721446 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) - pmid:24027553 + pmid:28901280 - act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") + a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) - pmid:24027553 + pmid:14556719 - act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") + a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) - pmid:24027553 + pmid:19126755 - act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:Inflammation) + a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:24027553 + pmid:19126755 - act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates") + a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:24590577 + pmid:28901280 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) + a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:24590577 + pmid:28901280 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) + a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) - pmid:24590577 + pmid:19126755 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") + a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - - - - - pmid:24590577 + pmid:28901280 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") + a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) - pmid:24590577 + pmid:28901280 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") + a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") - pmid:24590577 + pmid:24027553 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") + a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin)) - pmid:24590577 + pmid:19126755 - a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) - pmid:24590577 + pmid:19293145 - a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") + act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta")) - pmid:24590577 + pmid:19293145 - a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta") + act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:24590577 + pmid:26813123 - a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha") + a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) - pmid:24590577 + pmid:26813123 - a(CHEBI:cevimeline) increases path(MESH:Confusion) + a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) - pmid:24590577 + pmid:19126755 - a(CHEBI:cevimeline) increases path(MESH:Diarrhea) + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:24590577 + pmid:19126755 - a(CHEBI:cevimeline) increases path(MESH:Asthenia) + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) - pmid:24590577 + pmid:19126755 - a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:24590577 + pmid:18986241 - a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha") + a(CHEBI:physostigmine) decreases path(MESH:D000544) - pmid:24590577 + pmid:19126755 - a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta") + a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) - pmid:24590577 + pmid:19126755 - a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) + a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) - pmid:24590577 + pmid:17009926 - a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine)) - pmid:24590577 + pmid:17009926 - a(MESH:"WAY 132983") increases bp(GO:cognition) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine)) - pmid:24590577 + pmid:17009926 - a(MESH:"WAY 132983") increases path(MESH:Salivation) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline)) - pmid:24590577 + pmid:17009926 - a(MESH:"WAY 132983") increases path(MESH:Hypothermia) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin)) - pmid:24590577 + pmid:17009926 - a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)")) - - - - - pmid:24590577 + pmid:17009926 - a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:24590577 + pmid:17009926 - a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") + a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) - pmid:24590577 + pmid:19126755 - a(HBP:VU0184670) increases act(p(HGNC:CHRM1)) + a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) - pmid:24590577 + pmid:19126755 - a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") + a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) - pmid:26088141 + pmid:19126755 - p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) + a(HBP:"FK1 antibody") decreases a(CHEBI:codeine) - - - - - - - - - - - - - pmid:26088141 + pmid:19126755 - p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) + a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) - - - - - pmid:26088141 + pmid:19126755 - p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - - - - - - - pmid:26088141 + pmid:19126755 - composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) + path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - pmid:26088141 + pmid:19126755 - p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1") + path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") - pmid:26088141 + pmid:19126755 - p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR") + path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly") + path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) + path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(MESH:Schizophrenia) association path(MESH:Hallucinations) - pmid:26088141 + pmid:19721446 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(MESH:Schizophrenia) association path(MESH:Hallucinations) - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(MESH:Schizophrenia) association path(MESH:Delusions) - pmid:26088141 + pmid:19721446 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(MESH:Schizophrenia) association path(MESH:Delusions) - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) association bp(GO:cognition) - pmid:26088141 + pmid:19721446 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) association bp(GO:cognition) - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) association bp(GO:behavior) - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) + path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) + path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") + path(MESH:Schizophrenia) association path(MESH:Attention) - pmid:26088141 + pmid:24511233 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") + path(MESH:Schizophrenia) association path(MESH:"Executive Function") - pmid:26088141 + pmid:24511233 - g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) + path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") - - - - - - - - - - - - - - - - - - - - - pmid:26088141 + pmid:24511233 - composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") - pmid:26088141 + pmid:17009926 - composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association p(FPLX:CHRN) - - - - - pmid:26088141 + pmid:17009926 - composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association p(FPLX:CHRN) - pmid:26088141 + pmid:21482353 - composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) - pmid:26088141 + pmid:11230871 - a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association p(FPLX:CHRN) - pmid:26088141 + pmid:21482353 - a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) - pmid:26088141 + pmid:21482353 - a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") + path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") - pmid:26088141 + pmid:21482353 - a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") + path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) - pmid:26088141 + pmid:21482353 - a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) - pmid:26088141 + pmid:21482353 - a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) + path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:26088141 + pmid:21482353 - a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) + path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:26088141 + pmid:21482353 - a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") + path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) - pmid:26088141 + pmid:11230871 - a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") + path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR") - pmid:26088141 + pmid:11230871 - a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") + path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR") - pmid:26088141 + pmid:19721446 - a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") - pmid:26088141 + pmid:19721446 - bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) + path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) - pmid:26088141 + pmid:22040696 - a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) + path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) - pmid:26088141 + pmid:22040696 - a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") + path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) - pmid:26088141 + pmid:19126755 - a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) - - - - - pmid:25514383 + pmid:19126755 - a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:26195256 + pmid:19126755 - a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") + path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:24762290 + pmid:19126755 - a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") + path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) - pmid:25514383 + pmid:30106381 - a(HP:"cholinergic neuron") association bp(GO:cognition) + path(HBP:Neurodegeneration) association p(HGNC:WFS1) - pmid:25514383 + pmid:29758300 - a(HP:"cholinergic neuron") increases bp(GO:cognition) + path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:25514383 + pmid:18930136 - a(HP:"cholinergic neuron") association path(MESH:Attention) + path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25514383 + pmid:18930136 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") - pmid:25514383 + pmid:24027553 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") + path(HBP:Neurodegeneration) association p(MGI:Mapt, var("p.P301L")) - pmid:28445721 + pmid:17403556 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:21482353 + pmid:26631930 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") + path(HBP:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") + a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") + a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") + a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") + a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") + a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction") + a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph)) + a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:25514383 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) + a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") - pmid:25514383 + pmid:23383175 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) + a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) - pmid:25514383 + pmid:23383175 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") + a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") - pmid:25514383 + pmid:28803412 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) + a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) - pmid:25514383 + pmid:30108137 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) + a(MESH:Astrocytes) increases p(MGI:Tfeb) - pmid:25514383 + pmid:30108137 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) + act(a(MESH:Astrocytes)) increases a(HBP:"Tau fibrils") - pmid:25514383 + pmid:26195256 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") + act(a(MESH:Astrocytes)) decreases p(HGNC:APP) - pmid:25514383 + pmid:26195256 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) + a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) - pmid:25514383 + pmid:18562203 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) + act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - pmid:25514383 + pmid:27314526 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") + a(MESH:Astrocytes) increases p(HGNC:NLRP3) - pmid:28445721 + pmid:27314526 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") + a(MESH:Astrocytes) increases p(HGNC:TLR4) - pmid:28445721 + pmid:27314526 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) + a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) - pmid:21482353 + pmid:19126755 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) + a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid") - pmid:21482353 + pmid:19126755 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") + a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") - pmid:21482353 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") + bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") - pmid:21482353 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") + act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid") - pmid:21482353 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") + a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") - pmid:21482353 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") + a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine") - pmid:21482353 + pmid:19126755 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) + a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") - pmid:28132910 + pmid:19165623 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973") + a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") - pmid:25514383 + pmid:19623258 - a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta")) + a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP2CA) - - - - - pmid:25514383 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) + a(CHEBI:"quinolinic acid") decreases p(HGNC:PPP1CA) - pmid:25514383 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates") + a(CHEBI:"quinolinic acid") directlyIncreases act(complex(GO:"NMDA selective glutamate receptor complex")) - pmid:25514383 + pmid:19623258 - p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) + a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25514383 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") + a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) - pmid:25514383 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") + a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) - pmid:25514383 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") + a(CHEBI:"quinolinic acid") increases r(HGNC:WISP1) - pmid:27522251 + pmid:19623258 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") + a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) - - - - - - - - - pmid:25514383 + pmid:19623258 - a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR")) + a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) - pmid:25514383 + pmid:19623258 - a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) - - - - - pmid:25514383 + pmid:19623258 - composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) - pmid:28420982 + pmid:19623258 - bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) + a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) - pmid:25514383 + pmid:19623258 - a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) - pmid:28901280 + pmid:19126755 - bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) + act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) - pmid:30126037 + pmid:19126755 - bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") + p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) - pmid:24563850 + pmid:19293145 - bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") + p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") - pmid:30126037 + pmid:25514383 - bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) + p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") - pmid:28420982 + pmid:25881725 - bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT)) + act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") @@ -52812,16 +53515,16 @@

Statements

pmid:25514383 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") + p(MGI:Chrna7) decreases p(MGI:Syp) - pmid:28901280 + pmid:25514383 - path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") + p(MGI:Chrna7) decreases p(MGI:Map2) @@ -52830,7 +53533,7 @@

Statements

pmid:25514383 - a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) + p(MGI:Chrna7) increases p(MGI:Map2) @@ -52839,7 +53542,7 @@

Statements

pmid:25514383 - a(CHEBI:"(-)-cotinine") increases bp(GO:memory) + p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta") @@ -52848,7 +53551,7 @@

Statements

pmid:25514383 - a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") + p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta") @@ -52857,7 +53560,7 @@

Statements

pmid:25514383 - a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) + p(MGI:Chrna7) increases bp(GO:cognition) @@ -52866,7 +53569,7 @@

Statements

pmid:25514383 - a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") @@ -52875,1400 +53578,1385 @@

Statements

pmid:25514383 - a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta") + p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") - pmid:25514383 + pmid:27522251 - a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") - pmid:25514383 + pmid:27522251 - bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") + p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") - pmid:27314526 + pmid:27522251 - bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") + p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") - pmid:25514383 + pmid:27522251 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") + p(MGI:Chrna7) association bp(GO:aging) - pmid:17640819 + pmid:27522251 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") + p(MGI:Chrna7) increases a(HBP:HBP00022) - pmid:25514383 + pmid:25881725 - a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") + act(p(MGI:Chrna7)) increases bp(GO:learning) - pmid:17640819 + pmid:25881725 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") + p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17640819 + pmid:28901280 - a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) + p(MGI:Chrna7) association act(a(MESH:Epithelium)) - pmid:17640819 + pmid:21482353 - a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) + a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") - pmid:17640819 + pmid:19126755 - a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") + bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) - pmid:17640819 + pmid:19126755 - a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") + bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) - pmid:17640819 + pmid:24760868 - a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") + bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) - pmid:17640819 + pmid:28420982 - a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") + bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) - pmid:25514383 + pmid:28420982 - a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") + bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") - pmid:25514383 + pmid:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) + a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) - pmid:25514383 + pmid:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") + a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:25514383 + pmid:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") + a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:25514383 + pmid:19126755 - a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:25514383 + pmid:19126755 - a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") + a(CHEBI:anandamide) association p(HGNC:CNR1) - pmid:25514383 + pmid:19126755 - a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") + a(CHEBI:anandamide) association p(HGNC:CNR2) - pmid:25514383 + pmid:19126755 - a(CHEBI:simvastatin) increases bp(GO:cognition) + a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") - pmid:25514383 + pmid:19126755 - a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") - pmid:29626319 + pmid:19126755 - a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") - pmid:29626319 + pmid:19126755 - a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") - pmid:29626319 + pmid:19126755 - a(CHEBI:simvastatin) increases sec(p(HGNC:MME)) + a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) - pmid:21718217 + pmid:19126755 - bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) + a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - - - - - pmid:25514383 + pmid:19126755 - composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) + a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") - pmid:25881725 + pmid:19126755 - p(MGI:App, frag("25_35")) decreases bp(GO:learning) + p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42") - - - pmid:25881725 - - p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") - + - pmid:25881725 + pmid:19293145 - p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region")) + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) - pmid:25881725 + pmid:17009926 - p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") - - - - - - pmid:25514383 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") - - - - - pmid:25514383 + pmid:19126755 - complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CNR1) association a(CHEBI:anandamide) - pmid:25514383 + pmid:19126755 - a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) + p(HGNC:CNR2) association a(CHEBI:anandamide) - pmid:25514383 + pmid:19126755 - a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) + a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) - pmid:25514383 + pmid:19126755 - a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta")) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) + a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") - pmid:27522251 + pmid:28391535 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) + a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System")) - pmid:27522251 + pmid:28391535 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") + a(CHEBI:bupropion) decreases path(MESH:Depression) - pmid:27522251 + pmid:28391535 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) + a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine)) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR")) - pmid:27522251 + pmid:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) - - - - - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood") - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + path(MESH:"Smoking Cessation") increases path(MESH:Anger) - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) + path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological") - - - - - pmid:27522251 + pmid:28391535 - complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") + path(MESH:"Smoking Cessation") increases path(MESH:Anxiety) - - - - - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders") - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + path(MESH:"Smoking Cessation") increases path(MESH:Depression) - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") + path(MESH:"Smoking Cessation") increases path(MESH:Craving) - pmid:27522251 + pmid:28391535 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022) + path(MESH:"Smoking Cessation") decreases bp(GO:cognition) - pmid:24762290 + pmid:28391535 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) + path(MESH:"Smoking Cessation") decreases path(MESH:Attention) - pmid:24762290 + pmid:28391535 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) + path(MESH:"Smoking Cessation") increases path(MESH:Appetite) - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons) + p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) + act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") + act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") + p(FPLX:PI3K) increases act(a(MESH:Synapses)) - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") + act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") - pmid:24762290 + pmid:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") + p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) - pmid:24762290 + pmid:22040696 - complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory) + act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") - pmid:24762290 + pmid:30116051 - a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") + act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") - pmid:24762290 + pmid:26813123 - a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") + p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph)) - pmid:24762290 + pmid:24653673 - a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") + p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(Ph, Ser)) - pmid:21718217 + pmid:24653673 - a(HBP:HBP00089) association bp(GO:"microglial cell activation") + p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(Ph, Ser)) - pmid:21718217 + pmid:12428809 - a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph)) - pmid:21718217 + pmid:29191965 - a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:21718217 + pmid:26631930 - a(HBP:HBP00089) increases sec(p(HGNC:TNF)) + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + + - pmid:21718217 + pmid:22908190 - a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) + act(p(FPLX:PKA)) increases p(HGNC:UCHL1) - pmid:21718217 + pmid:30116051 - a(HBP:HBP00089) increases sec(p(HGNC:IL6)) + act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120)) - pmid:21718217 + pmid:25331948 - a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) + p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:23702978 + pmid:25331948 - p(HGNC:IFNG) increases p(HGNC:AIM2) + p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + + - pmid:23702978 + pmid:25331948 - p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) + act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(Ph)) - pmid:23702978 + pmid:26631930 - p(HGNC:IFNG) increases act(p(HGNC:NOS2)) + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:23702978 + pmid:23001711 - p(HGNC:IFNG) increases p(HGNC:CARD17) + act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:23702978 + pmid:17493042 - act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) - pmid:24561250 + pmid:17078951 - p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:24561250 + pmid:17078951 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:27314526 + pmid:17078951 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:24561250 + pmid:17078951 - p(HGNC:IL1B) increases bp(GO:"inflammatory response") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:27314526 + pmid:17078951 - p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217)) - pmid:27314526 + pmid:17078951 - p(HGNC:IL1B) increases bp(GO:"microglial cell activation") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:27314526 + pmid:17078951 - p(HGNC:IL1B) increases bp(GO:"astrocyte activation") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:27314526 + pmid:17078951 - sec(p(HGNC:IL1B)) increases p(HGNC:APP) + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:27314526 + pmid:17078951 - sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") + p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:21718217 + pmid:17078951 - act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") + p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212)) - pmid:21718217 + pmid:17078951 - act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) + p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) - pmid:21718217 + pmid:17078951 - act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") + p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) - pmid:21718217 + pmid:17078951 - act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") + p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) - pmid:21718217 + pmid:17078951 - p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") + p(FPLX:PKA) decreases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) - pmid:21718217 + pmid:17078951 - p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") + p(FPLX:PKA) increases complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) - pmid:21718217 + pmid:26692334 - p(HGNC:PPARG) association bp(GO:"response to insulin") + act(p(FPLX:PKA)) positiveCorrelation a(CHEBI:rolipram) - pmid:21718217 + pmid:26692334 - p(HGNC:PPARG) association bp(GO:"lipid storage") + act(p(FPLX:PKA)) positiveCorrelation act(complex(GO:"proteasome complex")) - pmid:21718217 + pmid:19721446 - p(HGNC:PPARG) increases p(HGNC:APOE) + act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) - pmid:21718217 + pmid:23001711 - p(HGNC:PPARG) increases p(HGNC:ABCA1) + p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:21718217 + pmid:19126755 - p(HGNC:PPARG) increases p(HGNC:NR1H3) + act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") - pmid:21718217 + pmid:19126755 - act(p(HGNC:PPARG)) increases p(HGNC:ARG1) + act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") + + - pmid:21718217 + pmid:19293145 - act(p(HGNC:PPARG)) increases p(HGNC:IL4) + act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") - pmid:21718217 + pmid:28784767 - act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") + act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:21718217 + pmid:28784767 - act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:21718217 + pmid:25001178 - act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6)) - pmid:21718217 + pmid:25001178 - act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") + act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin)) - pmid:21718217 + pmid:19126755 - act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") + path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) - pmid:21718217 + pmid:19126755 - p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") + path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) - pmid:21718217 + pmid:19126755 - p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") - pmid:21718217 + pmid:19126755 - p(HGNC:NR1H3) increases p(HGNC:APOE) + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") - pmid:21718217 + pmid:19126755 - act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) + path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) - pmid:21718217 + pmid:19126755 - p(HGNC:NR1H3) increases p(HGNC:ABCA1) + path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") - pmid:21718217 + pmid:19126755 - act(p(HGNC:NR1H3)) increases bp(GO:memory) + path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") - pmid:21718217 + pmid:19126755 - act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") + path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) - + + + pmid:19126755 + + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") + - pmid:21718217 + pmid:19126755 - p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") + path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") - pmid:21718217 + pmid:19126755 - p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") + path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") - pmid:21718217 + pmid:19126755 - p(FPLX:PPAR) association bp(GO:"fat cell differentiation") + path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:21718217 + pmid:28445721 - p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") + path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) - pmid:21718217 + pmid:21482353 - p(FPLX:PPAR) association bp(GO:"response to insulin") + path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) - pmid:21718217 + pmid:21482353 - p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:21718217 + pmid:21482353 - p(FPLX:PPAR) association bp(GO:"response to tumor cell") + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:21718217 + pmid:21482353 - p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") + path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) - pmid:21718217 + pmid:21482353 - p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:21718217 + pmid:21482353 - act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:21718217 + pmid:21482353 - act(p(FPLX:RXR)) increases p(HGNC:APOE) + path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:21718217 + pmid:21787755 - act(p(FPLX:RXR)) increases p(HGNC:ABCA1) + path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) - + + + pmid:21787755 + + path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") + - pmid:21718217 + pmid:21787755 - bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) + path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") - pmid:21718217 + pmid:28901280 - bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) + path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) - pmid:21718217 + pmid:19126755 - bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) + bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) - pmid:21718217 + pmid:19126755 - bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) + a(MESH:Skin) association act(a(CHEBI:nicotine)) - pmid:25784053 + pmid:29626319 - bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) + a(MESH:Skin) decreases a(CHEBI:"amyloid-beta") - pmid:21718217 + pmid:29626319 - bp(GO:"fat cell differentiation") association p(FPLX:PPAR) + a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21718217 + pmid:29626319 - bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) + a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21718217 + pmid:19126755 - bp(GO:"response to insulin") association p(FPLX:PPAR) + path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") - pmid:21718217 + pmid:19126755 - bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) + path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") - pmid:21718217 + pmid:19126755 - bp(GO:"response to insulin") association p(HGNC:PPARG) + path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") - pmid:21718217 + pmid:28901280 - bp(GO:"response to tumor cell") association p(FPLX:PPAR) + path(MESH:Neoplasms) association p(HGNC:CHRNA7) - pmid:21718217 + pmid:22020111 - bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) + path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) - pmid:21718217 + pmid:22020111 - p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") + path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) - pmid:21718217 + pmid:23454242 - p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") + path(MESH:Neoplasms) association p(FPLX:PPP2) - pmid:21718217 + pmid:23454242 - bp(GO:"lipid storage") association p(HGNC:PPARG) + path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2)) - pmid:21718217 + pmid:22299660 - p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") + path(MESH:Neoplasms) association p(FPLX:PPP2) - pmid:21718217 + pmid:25784053 - act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") + path(MESH:Neoplasms) association act(p(HGNC:HSF1)) - pmid:21718217 + pmid:18930136 - act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") + path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") - pmid:21718217 + pmid:24563850 - act(p(HGNC:PPARD)) increases p(HGNC:ARG1) + path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") - pmid:21718217 + pmid:24563850 - act(p(HGNC:PPARD)) increases p(HGNC:IL4) + path(MESH:Neoplasms) association bp(GO:"protein oxidation") - pmid:21718217 + pmid:29311797 - bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) + path(MESH:Neoplasms) association p(HGNC:STUB1) - pmid:21718217 + pmid:22807490 - a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) - pmid:21718217 + pmid:23746257 - a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + bp(GO:"cell cycle") association p(FPLX:HSP90) - pmid:21718217 + pmid:30126037 - bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) + bp(GO:"cell cycle") association bp(GO:"cellular senescence") - pmid:21718217 + pmid:19126755 - a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") - pmid:30116051 + pmid:19126755 - a(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") + path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") @@ -54277,1289 +54965,1292 @@

Statements

pmid:21718217 - a(HBP:HBP00030) increases a(HBP:HBP00018) + path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) - pmid:30116051 + pmid:19126755 - a(HBP:HBP00030) increases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) - pmid:30116051 + pmid:19126755 - a(HBP:HBP00030) increases p(HGNC:LGMN) + a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:21718217 + pmid:19126755 - p(HGNC:ABCA1) increases p(HGNC:APOE) + a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:21718217 + pmid:19126755 - p(HGNC:ABCA1) decreases a(HBP:HBP00018) + a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:21718217 + pmid:19126755 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:24511233 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:26195256 + pmid:24590577 - p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:24027553 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:24590577 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") - pmid:29626319 + pmid:24027553 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph)) - pmid:28019679 + pmid:24027553 - p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac)) - pmid:30116051 + pmid:24027553 - p(HGNC:IDE) increases deg(p(HGNC:IAPP)) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration)) - pmid:30116051 + pmid:24027553 - p(HGNC:IDE) decreases a(HBP:HBP00016) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) - pmid:30116051 + pmid:24027553 - p(HGNC:IDE) decreases a(HBP:HBP00018) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) - pmid:30116051 + pmid:24027553 - p(HGNC:IDE) decreases a(HBP:HBP00092) + path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) - pmid:29626319 + pmid:24027553 - p(HGNC:IDE) negativeCorrelation bp(GO:aging) + path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:CAPN2) - pmid:29626319 + pmid:24027553 - p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") + path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) - pmid:28019679 + pmid:24027553 - p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") + path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) - pmid:21718217 + pmid:24027553 - a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) + path(MESH:"Neurofibrillary Tangles") positiveCorrelation p(HGNC:MAPT, pmod(Ub)) - pmid:21718217 + pmid:19126755 - a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) + path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21718217 + pmid:19126755 - a(CHEBI:"GW 3965") increases p(HGNC:APOE) + p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration) - pmid:21718217 + pmid:25514383 - a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) + p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) - pmid:21718217 + pmid:25514383 - a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) + p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") - pmid:21718217 + pmid:25514383 - a(CHEBI:"GW 3965") increases bp(GO:memory) + p(MGI:Chrnb2) increases path(MESH:Attention) - pmid:21718217 + pmid:25514383 - a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) + p(MGI:Chrnb2) increases bp(GO:cognition) - pmid:21718217 + pmid:27522251 - a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) + p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") - pmid:21718217 + pmid:27522251 - a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) + p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta") - pmid:21718217 + pmid:19126755 - p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta") + p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) - pmid:21718217 + pmid:19126755 - p(MGI:Abca1) decreases a(HBP:HBP00038) + a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) + a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta") - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) + a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity) - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) + a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity) - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) - pmid:21718217 + pmid:19293145 - a(CHEBI:pioglitazone) increases bp(GO:behavior) + a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) - pmid:21718217 + pmid:26813123 - a(CHEBI:pioglitazone) increases p(MGI:Abca1) + a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) - pmid:21718217 + pmid:30145931 - a(CHEBI:pioglitazone) increases p(MGI:Apoe) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:21718217 + pmid:24760868 - a(CHEBI:pioglitazone) increases bp(GO:memory) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) - pmid:21718217 + pmid:24760868 - a(CHEBI:pioglitazone) increases bp(GO:cognition) + a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) - pmid:29626319 + pmid:24760868 - a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta") + a(HBP:"amyloid-beta oligomers") increases tloc(p(HGNC:MAPT)) - pmid:21718217 + pmid:23528736 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT) - pmid:21718217 + pmid:30145931 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:29626319 + pmid:30145931 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) - pmid:21718217 + pmid:30145931 - a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:21718217 + pmid:30145931 - a(CHEBI:rosiglitazone) increases bp(GO:behavior) + a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018) + a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:21718217 + pmid:17403556 - a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:21718217 + pmid:17403556 - a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta") + a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) - pmid:29626319 + pmid:24760868 - a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") + a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) + a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) increases p(MGI:Abca1) + a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) increases bp(GO:memory) + a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:21718217 + pmid:24760868 - a(CHEBI:rosiglitazone) increases bp(GO:cognition) + a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:29626319 + pmid:24760868 - a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) + a(HBP:"amyloid-beta oligomers") decreases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) - pmid:19732809 + pmid:24760868 - path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation a(HBP:"O-GlcNAcylation") + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:22798221 + pmid:24760868 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph)) - pmid:22798221 + pmid:22419736 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph)) - pmid:22798221 + pmid:24760868 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines")) - pmid:22798221 + pmid:23528736 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) - pmid:22798221 + pmid:22156579 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation p(INTERPRO:"Kinase associated domain 1 (KA1)") - pmid:22798221 + pmid:19126755 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") - pmid:22798221 + pmid:19126755 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + a(CHEBI:"NS-398") decreases p(HGNC:CHRNA4) - - - - - pmid:21718217 + pmid:19126755 - a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) + path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:21718217 + pmid:19126755 - a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) + path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:21718217 + pmid:19126755 - a(CHEBI:"GW 501516") increases p(HGNC:APOA1) + path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:21718217 + pmid:17009926 - a(CHEBI:"GW 501516") decreases a(HBP:HBP00018) + path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) - pmid:21718217 + pmid:19721446 - a(CHEBI:"GW 501516") increases p(HGNC:MME) + path(MESH:Craving) association p(HGNC:CHRNA3) - pmid:21718217 + pmid:19721446 - a(CHEBI:"GW 501516") increases p(HGNC:IDE) + path(MESH:Craving) association p(HGNC:CHRNB4) - pmid:21718217 + pmid:19126755 - a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) + a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine) - pmid:21718217 + pmid:19126755 - a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) + a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) - pmid:21718217 + pmid:19126755 - a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018) + path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) - pmid:21718217 + pmid:19126755 - a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR") - pmid:21718217 + pmid:19126755 - a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) + a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") - pmid:26400044 + pmid:11230871 - a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") + a(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging) - pmid:26400044 + pmid:11230871 - a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing") + a(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26400044 + pmid:19293145 - a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) + path(MESH:Death) association path(MESH:"Alzheimer Disease") - pmid:26400044 + pmid:19293145 - a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) + a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26400044 + pmid:19293145 - a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - pmid:21718217 + pmid:14556719 - a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - pmid:21718217 + pmid:14556719 - a(CHEBI:bexarotene) increases p(HGNC:APOE) + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) - pmid:21718217 + pmid:27574109 - a(CHEBI:bexarotene) increases p(HGNC:ABCA1) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - pmid:21718217 + pmid:22299660 - a(CHEBI:bexarotene) decreases a(HBP:HBP00018) + a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(Ph)) - pmid:21718217 + pmid:14556719 - a(CHEBI:bexarotene) increases bp(GO:behavior) + a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:21718217 + pmid:14556719 - a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) + a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:21718217 + pmid:14556719 - a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:21718217 + pmid:27574109 - a(CHEBI:Honokiol) increases p(HGNC:APOE) + a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers") - pmid:21718217 + pmid:27574109 - a(CHEBI:Honokiol) increases p(HGNC:ABCA1) + a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") - pmid:21718217 + pmid:23528736 - r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") - pmid:21718217 + pmid:19293145 - r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") - pmid:11230871 + pmid:16273023 - bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) + a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") - pmid:21718217 + pmid:16273023 - p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") + a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) - pmid:21718217 + pmid:21882945 - p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") + a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) + + + + + + - pmid:21718217 + pmid:19293145 - p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") + composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) + + + + - pmid:21718217 + pmid:19293145 - a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) + a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:17403556 - a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph)) - pmid:29758300 + pmid:17403556 - a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:29758300 + pmid:17403556 - a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:22908190 + pmid:17403556 - a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:22908190 + pmid:17403556 - a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:22908190 + pmid:17403556 - a(CHEBI:cholesterol) increases a(GO:endosome) + a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:21718217 + pmid:19293145 - p(HBP:HBP00030) association path(MESH:"Alzheimer Disease") + a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning") - pmid:21718217 + pmid:19293145 - p(HGNC:IL10) decreases a(MESH:Macrophages) + p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) - pmid:21718217 + pmid:18986241 - a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) + act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine)) - pmid:21718217 + pmid:18986241 - p(HGNC:TGFB1) decreases a(MESH:Macrophages) + p(HGNC:BCHE) association a(MESH:D016874) - pmid:26304819 + pmid:18986241 - p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:BCHE) association path(MESH:D058225) + + - pmid:28445721 + pmid:18986241 - path(MESH:Motivation) association p(FPLX:CHRN) + p(HGNC:BCHE) association path(MESH:D003071) - pmid:28445721 + pmid:19293145 - bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") - pmid:28445721 + pmid:19293145 - path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") - pmid:28445721 + pmid:19293145 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:19293145 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:19293145 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:22040696 + pmid:19293145 - act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) + a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection) - pmid:22040696 + pmid:17009926 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) - pmid:22040696 + pmid:17009926 - act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) + a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory) - pmid:28445721 + pmid:19293145 - p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:28391535 - p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:17009926 - p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") - pmid:22040696 + pmid:17009926 - p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:Mecamylamine) decreases path(MESH:Attention) - pmid:22040696 + pmid:26813123 - p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) - pmid:22040696 + pmid:11230871 - p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(CHEBI:Mecamylamine) decreases bp(GO:cognition) - pmid:22040696 + pmid:19721446 - p(HGNC:RIC3) increases p(HGNC:CHRNA9) + a(CHEBI:Mecamylamine) decreases bp(GO:cognition) - pmid:22040696 + pmid:28391535 - p(HGNC:RIC3) increases p(HGNC:CHRNA7) + a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) - pmid:22040696 + pmid:28391535 - act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") + a(CHEBI:Mecamylamine) increases path(MESH:Tremor) - pmid:22040696 + pmid:28391535 - act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") + a(CHEBI:Mecamylamine) increases path(MESH:Confusion) - pmid:28445721 + pmid:28391535 - p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) increases path(MESH:Seizures) - pmid:28445721 + pmid:28391535 - act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder") - pmid:28445721 + pmid:28391535 - act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:Mecamylamine) increases path(MESH:Depression) - pmid:28445721 + pmid:28391535 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) decreases path(MESH:Smoking) - pmid:28445721 + pmid:28391535 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:28445721 + pmid:28391535 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:28445721 + pmid:23038257 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) - - - pmid:28445721 - - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - + - pmid:28445721 + pmid:19293145 - p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) + a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta")) - pmid:28445721 + pmid:19293145 - p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) + a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) - pmid:28445721 + pmid:19293145 - p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) + act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:28445721 + pmid:23038257 - p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) + a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") - pmid:28445721 + pmid:23038257 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174)) + a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) - pmid:28445721 + pmid:23038257 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174)) + a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) - pmid:28445721 + pmid:25514383 - act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174) + a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) @@ -55568,268 +56259,272 @@

Statements

pmid:28445721 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2")) + a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + - pmid:28445721 + pmid:19293145 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2")) + composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:19293145 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2") + act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity) - pmid:28445721 + pmid:19293145 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4")) + a(MESH:Serum) decreases bp(GO:"cell death") - pmid:28445721 + pmid:24027553 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4")) + bp(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:28445721 + pmid:24183963 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4") + a(CHEBI:glucose) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:28445721 + pmid:24183963 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:glucose) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:28445721 + pmid:16630055 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) - pmid:28445721 + pmid:19293145 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) + a(CHEBI:thapsigargin) increases bp(GO:"cell death") - pmid:28445721 + pmid:19293145 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) + a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") - pmid:28445721 + pmid:29024336 - p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") - pmid:28445721 + pmid:19293145 - p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) - pmid:28445721 + pmid:19293145 - p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) - pmid:28445721 + pmid:19293145 - act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity) - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) association p(MGI:Canx) + act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration) - pmid:28445721 + pmid:26813123 - p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) + bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory) - pmid:28445721 + pmid:26813123 - p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) + bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") - pmid:28445721 + pmid:26813123 - p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) + bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") - pmid:28445721 + pmid:18986241 - p(MGI:Tmem35a) increases a(HBP:HBP00180) + bp(HBP:Neurodegeneration) association path(MESH:D060825) - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) increases complex(a(GO:membrane), a(MESH:Bungarotoxins)) + act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) increases p(FPLX:CHRN) + act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") - pmid:28445721 + pmid:23702978 - p(MGI:Tmem35a) regulates p(FPLX:CHRN) + act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) - pmid:28445721 + pmid:23702978 - p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") + act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) decreases bp(GO:locomotion) + bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) decreases bp(GO:locomotion) + p(FPLX:SRC) increases act(a(CHEBI:nicotine)) - pmid:28445721 + pmid:17009926 - p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") + act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph)) - pmid:28445721 + pmid:22040696 - p(MGI:Tmem35a) increases bp(GO:learning) + act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) - pmid:28445721 + pmid:22040696 - p(MGI:Tmem35a) increases bp(GO:memory) + act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) - pmid:28445721 + pmid:25514383 - p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") + p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process") - pmid:28445721 + pmid:19293145 - p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") + a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) @@ -55844,245 +56539,207 @@

Statements

- pmid:11230871 + pmid:19293145 - complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph)) - pmid:11230871 + pmid:18680553 - complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph)) - - - - - - - - - - - - - - - - - pmid:28445721 + pmid:19293145 - p(MGI:Canx) association p(MGI:Tmem35a) + p(HGNC:FYN) increases bp(GO:cognition) - - - - - pmid:18174175 + pmid:19293145 - complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + p(HGNC:FYN) increases act(p(FPLX:PI3K)) - pmid:21787755 + pmid:19293145 - a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph)) - pmid:28445721 + pmid:19293145 - a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + p(HGNC:FYN) decreases bp(GO:"apoptotic process") - pmid:21787755 + pmid:19293145 - a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + p(HGNC:FYN) association bp(MESH:Neuroprotection) - - - - - - - - - - - - - pmid:28445721 + pmid:19293145 - bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) + p(HGNC:FYN) increases bp(MESH:Neuroprotection) - - - - - pmid:21482353 + pmid:19293145 - a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta")) - pmid:27671637 + pmid:19293145 - a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) - pmid:21482353 + pmid:19293145 - p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) + p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) - pmid:21482353 + pmid:19293145 - p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) - pmid:21482353 + pmid:24760868 - p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) + p(HGNC:FYN, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:21482353 + pmid:30640040 - p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + p(HGNC:FYN) association a(PUBCHEM:4878) - pmid:21482353 + pmid:29191965 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - pmid:21482353 + pmid:26751493 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HGNC:FYN) association p(HBP:"projection domain") - pmid:21482353 + pmid:26631930 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) + p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:21482353 + pmid:17493042 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:21482353 + pmid:26631930 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph)) - pmid:21482353 + pmid:18680553 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + p(HGNC:FYN) association p(HGNC:MAPT) - pmid:21482353 + pmid:18680553 - p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) + p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226")) - - - pmid:21482353 + pmid:18680553 - complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) + p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) - pmid:21482353 + pmid:26751493 - complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) + p(HGNC:FYN) association a(HBP:"projection domain") @@ -56091,22 +56748,22 @@

Statements

- - - pmid:21482353 + pmid:19293145 - complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) + complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) + + - pmid:21482353 + pmid:19293145 - complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + p(MGI:Fyn) decreases bp(MESH:Neuroprotection) @@ -56115,190 +56772,166 @@

Statements

- pmid:21482353 + pmid:18096814 - complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) + p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") - pmid:21482353 + pmid:18096814 - complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) + p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) - - - - - pmid:21482353 + pmid:25125464 - complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) + p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") - pmid:21482353 + pmid:25125464 - complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) + act(p(MGI:Fyn)) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) - - - pmid:19721446 + pmid:25125464 - p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) + act(p(MGI:Fyn)) increases p(HBP:"Tau epitope, AT8") - - - pmid:21482353 + pmid:19293145 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) + p(HGNC:JAK2) increases bp(MESH:Neuroprotection) - pmid:21482353 + pmid:19293145 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) + p(HGNC:JAK2) association bp(MESH:Neuroprotection) - pmid:21482353 + pmid:19293145 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN)) + p(HGNC:JAK2) increases act(a(CHEBI:nicotine)) - - - pmid:21482353 + pmid:19293145 - p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) - pmid:21482353 + pmid:19293145 - p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21482353 + pmid:19293145 - p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + p(HGNC:JAK2) association act(p(HGNC:STAT3)) - pmid:21482353 + pmid:19293145 - p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + p(HGNC:JAK2) increases act(p(HGNC:FYN)) - - - pmid:21482353 - - p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") - - - - - pmid:21482353 - - p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") - - - pmid:21482353 + pmid:19293145 - p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") + complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:21482353 + pmid:24653673 - p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") + complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:26631930 - p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") + complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(HBP:Excitotoxicity) - pmid:21482353 + pmid:18680553 - p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") + complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) - pmid:28901280 + pmid:19293145 - p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph)) - pmid:28901280 + pmid:26631930 - p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) + p(HGNC:MAPT, pmod(Ph, Tyr)) increases a(HBP:"Tau aggregates") @@ -56309,578 +56942,576 @@

Statements

- - - pmid:21482353 + pmid:19293145 - composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) + p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr)) - - - pmid:21482353 + pmid:19293145 - complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2)) - - - - - pmid:21482353 + pmid:19293145 - complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) + p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine)) - - - - - pmid:21482353 + pmid:23038257 - complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR")) + p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) - - - pmid:21482353 + pmid:17009926 - a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) + p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7)) - pmid:21482353 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) + a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta")) - pmid:21482353 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") + a(CHEBI:estradiol) decreases path(HBP:neurotoxicity) - - - pmid:21482353 - - a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") - + + + - pmid:11230871 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging) + act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) - pmid:11230871 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) - - - pmid:11230871 - - a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) - + - pmid:11230871 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta")) + composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") + g(HGNC:NIN) association g(HGNC:GSK3B) - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") + g(HGNC:GSK3B) association g(HGNC:NIN) - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") + act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") + + + + - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") - pmid:21787755 + pmid:19293145 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph)) - pmid:21482353 + pmid:19293145 - p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph)) - pmid:21482353 + pmid:19293145 - p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph)) - pmid:21482353 + pmid:19293145 - p(MGI:Lynx1) decreases bp(GO:learning) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph)) - pmid:21482353 + pmid:19721446 - p(MGI:Lynx1) decreases bp(GO:memory) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) - pmid:21482353 + pmid:19721446 - p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") - pmid:21482353 + pmid:19721446 - p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) - pmid:21482353 + pmid:19721446 - p(MGI:Lynx1) increases a(MESH:Neurons) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:21482353 + pmid:19721446 - act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") - pmid:24027553 + pmid:19721446 - a(MESH:Brain) association act(p(HGNC:NPEPPS)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") - pmid:21482353 + pmid:19721446 - p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") - pmid:21482353 + pmid:19721446 - p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) - pmid:21482353 + pmid:19721446 - p(HGNC:PSCA) decreases bp(GO:"programmed cell death") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) - pmid:21482353 + pmid:19721446 - bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) + + - pmid:21482353 + pmid:18494933 - bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) + p(HGNC:MAPK8, pmod(Ph)) increases act(p(HGNC:MAPK8)) + + - pmid:21482353 + pmid:23528736 - bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:MAPK8) increases bp(GO:autophagy) - pmid:21482353 + pmid:23528736 - bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) + p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) - pmid:21482353 + pmid:23528736 - bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) + p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph)) - pmid:21482353 + pmid:18494933 - path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") + act(p(HGNC:MAPK8)) increases p(HGNC:JUN) - pmid:21482353 + pmid:11943212 - a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") + p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:21482353 + pmid:19293145 - act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) + a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph)) - pmid:21482353 + pmid:19293145 - a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph)) - pmid:21482353 + pmid:19293145 - act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) + a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941")) - pmid:24563850 + pmid:19293145 - act(p(FPLX:NOS)) increases a(CHEBI:radical) + act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") + + + + - pmid:24563850 + pmid:19293145 - act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") - pmid:24563850 + pmid:19293145 - act(p(FPLX:NOS)) increases a(CHEBI:"reactive nitrogen species") + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") - pmid:21482353 + pmid:19293145 - a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) - pmid:21482353 + pmid:19293145 - g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph)) - pmid:21482353 + pmid:19293145 - g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine)) + + + + + + - pmid:21482353 + pmid:19293145 - g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) - pmid:21482353 + pmid:19293145 - a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + act(p(FPLX:RAS)) increases p(HGNC:STAT3) - pmid:21482353 + pmid:18986241 - a(HBP:"GTS-21") increases path(MESH:Attention) + p(FPLX:RAS) association bp(GO:"GO:0014065") - pmid:21482353 + pmid:18986241 - a(HBP:"GTS-21") increases bp(GO:"sensory processing") + p(FPLX:RAS) association bp(GO:"GO:0043491") + + + + - pmid:21482353 + pmid:19293145 - a(HBP:"GTS-21") decreases path(MESH:Anhedonia) + composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph)) - pmid:21482353 + pmid:19293145 - a(HBP:"GTS-21") decreases path(MESH:Aphasia) + act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity) - pmid:21482353 + pmid:19293145 - p(HGNC:SLC12A5) decreases a(CHEBI:chloride) + bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta")) - pmid:21482353 + pmid:19293145 - p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) + bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) - pmid:21482353 + pmid:19293145 - p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) + bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) - - - pmid:21482353 + pmid:19293145 - a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) + bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) - pmid:21482353 + pmid:19293145 - p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") + bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21482353 + pmid:23746257 - p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) + bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) - pmid:21482353 + pmid:25514383 - path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) + bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR") - pmid:21482353 + pmid:25514383 - bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR") + bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") @@ -56889,457 +57520,493 @@

Statements

pmid:21482353 - bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR") + bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:21482353 + pmid:19293145 - bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) + a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) - pmid:23746257 + pmid:19721446 - bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") + a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") - pmid:25784053 + pmid:19293145 - bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) + a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) - pmid:21482353 + pmid:19293145 - path(MESH:Fear) increases a(CHEBI:dopamine) + p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) - pmid:21482353 + pmid:19293145 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) + act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") + + - pmid:21482353 + pmid:19293145 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) + p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) - pmid:21482353 + pmid:19293145 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) + act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") + + + + + + - pmid:21482353 + pmid:19293145 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph)) - pmid:21482353 + pmid:19293145 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") + + + + - pmid:21482353 + pmid:19293145 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis") + + + + + + + + - pmid:21482353 + pmid:19293145 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") + + + + - pmid:21482353 + pmid:19293145 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") - pmid:21482353 + pmid:19293145 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + g(HGNC:APOE) increases p(HGNC:APOE) - pmid:21482353 + pmid:19293145 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) + g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:19293145 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) + g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21482353 + pmid:19293145 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) + g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) - pmid:19721446 + pmid:19293145 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) + g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) - pmid:19721446 + pmid:19293145 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) + g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:19721446 + pmid:19293145 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) + bp(GO:"lipid metabolic process") association p(HGNC:APOE) - pmid:28901280 + pmid:19293145 - path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) + bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) - pmid:28901280 + pmid:19293145 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) + p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) + + + + - pmid:28901280 + pmid:19293145 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) + act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol) - pmid:28901280 + pmid:24590577 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) + a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) - pmid:21482353 + pmid:26751493 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") - pmid:21482353 + pmid:26751493 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) + a(CHEBI:phosphatidylinositol) association a(HBP:"projection domain") - pmid:21482353 + pmid:19293145 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) - pmid:21482353 + pmid:26195256 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + p(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") - pmid:21482353 + pmid:26195256 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + p(HBP:"APOE e4") regulates a(MESH:"Blood-Brain Barrier") - pmid:21482353 + pmid:26195256 - p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) + p(HBP:"APOE e4") decreases bp(HBP:"perivascular drainage pathways") - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HBP:"APOE e4") increases p(MGI:Cdk5) - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) + p(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25") - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + p(HBP:"APOE e4") increases p(MGI:Cdk5r1) - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + p(HBP:"APOE e4") increases p(MGI:Capn1) - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + p(HBP:"APOE e4") increases p(MGI:Capn2) - pmid:21482353 + pmid:27087442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) + p(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b) - pmid:21482353 + pmid:28720530 - path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") + p(HBP:"APOE e4") directlyDecreases p(HGNC:PPP2R5E) - pmid:18986241 + pmid:28720530 - path(MESH:D019636) association path(MESH:D000544) + p(HBP:"APOE e4") negativeCorrelation complex(GO:"protein phosphatase type 2A complex") - pmid:18986241 + pmid:19293145 - path(MESH:D001526) association path(MESH:D000544) + a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) - pmid:18986241 + pmid:30145931 - path(HBP:aMCI) association path(MESH:D008569) + a(CHEBI:wortmannin) decreases bp(GO:autophagy) - pmid:18986241 + pmid:30145931 - path(HBP:aMCI) association path(MESH:D003704) + a(CHEBI:wortmannin) increases p(HGNC:MAPT) - pmid:18986241 + pmid:30145931 - path(HBP:aMCI) association path(MESH:D000544) + a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:18986241 + pmid:30145931 - path(MESH:D008569) association path(HBP:aMCI) + a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) - pmid:18986241 + pmid:30145931 - path(HBP:mdMCI) association path(MESH:D060825) + a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:18986241 + pmid:30145931 - path(MESH:D060825) association path(HBP:mdMCI) + a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:18986241 + pmid:30145931 - path(MESH:D060825) association path(MESH:D062706) + a(CHEBI:wortmannin) decreases a(MESH:"Dendritic Spines") + + + + - pmid:18986241 + pmid:19293145 - path(MESH:D060825) association bp(HBP:Neurodegeneration) + composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) - pmid:18986241 + pmid:19293145 - path(MESH:D060825) causesNoChange act(p(HGNC:CHAT)) + composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) + + + + - pmid:18986241 + pmid:22040696 - path(MESH:D060825) increases act(p(HGNC:CHAT)) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19293145 - path(MESH:D060825) increases act(p(HGNC:CHAT)) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity) - pmid:18986241 + pmid:19293145 - path(MESH:D060825) decreases a(MESH:D013569) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) @@ -57348,7 +58015,7 @@

Statements

pmid:18986241 - path(MESH:D060825) increases a(MESHC:"pro-nerve growth factor, human") + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) @@ -57357,205 +58024,216 @@

Statements

pmid:18986241 - path(MESH:D060825) increases act(p(HGNC:MMP9)) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271") - pmid:18986241 + pmid:22040696 - path(MESH:D060825) causesNoChange r(HGNC:CHAT) + complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") + + + + - pmid:18986241 + pmid:19293145 - path(MESH:D060825) association p(HGNC:CHRM1) + composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) + + + + - pmid:18986241 + pmid:19293145 - path(MESH:D060825) decreases a(HBP:"3R tau") + composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + + + + - pmid:18986241 + pmid:19293145 - path(MESH:D062706) association path(MESH:D060825) + composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + + + + - pmid:18986241 + pmid:19293145 - a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") + complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") - pmid:18986241 + pmid:19293145 - a(MESH:D059329) association path(MESH:D008568) + bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) - pmid:18986241 + pmid:24653673 - a(MESH:D059329) association path(MESH:D001288) + bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) - pmid:18986241 + pmid:24653673 - a(MESH:D059329) association a(MESH:D016874) + bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) - pmid:18986241 + pmid:29191965 - a(MESH:D059329) association path(MESH:D000544) + bp(GO:"insulin receptor signaling pathway") positiveCorrelation composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) - pmid:18986241 + pmid:19293145 - a(MESH:D059329) association a(MESH:D009479) + bp(GO:"choline transport") association a(CHEBI:"amyloid-beta") + + + + - pmid:18986241 + pmid:19293145 - a(MESH:D059329) association a(MESH:D059330) + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19293145 - a(MESH:D059329) association p(RGD:Gal) + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) - pmid:18986241 + pmid:19293145 - a(MESH:D059329) association path(MESH:D008570) + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) + + + + - pmid:18986241 + pmid:25514383 - a(MESH:D059329) association path(MESH:D003704) + a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:18986241 + pmid:25514383 - bp(GO:"GO:0060384") association p(HGNC:NGF) + a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) - - - pmid:18986241 - - path(MESH:D001288) association a(MESH:D059329) - + - pmid:18986241 + pmid:19293145 - a(MESH:D016874) association a(MESH:D059329) + p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:18986241 + pmid:19293145 - a(MESH:D016874) association path(MESH:D000544) + p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) - - - pmid:18986241 - - a(MESH:D016874) association p(HGNC:BCHE) - + - - - pmid:18986241 - - a(MESH:D009479) association a(MESH:D059329) - + + + - pmid:18986241 + pmid:19721446 - a(MESH:D059330) association a(MESH:D059329) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") - pmid:18986241 + pmid:21482353 - p(RGD:Gal) association a(MESH:D059329) + p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) @@ -57564,7 +58242,7 @@

Statements

pmid:18986241 - path(MESH:D008570) association a(MESH:D059329) + r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071) @@ -57573,7 +58251,7 @@

Statements

pmid:18986241 - a(MESH:D005625) positiveCorrelation path(MESH:D011597) + r(HGNC:CHRNA7) regulates act(a(MESH:D059329)) @@ -57582,16 +58260,16 @@

Statements

pmid:18986241 - path(MESH:D011597) positiveCorrelation a(MESH:D005625) + r(HGNC:CHRNA7) increases path(MESH:D009410) - pmid:18986241 + pmid:11230871 - p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) + r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") @@ -57602,146 +58280,126 @@

Statements

- pmid:18986241 + pmid:19293145 - complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180") + composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7) - pmid:18986241 + pmid:19293145 - complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") + composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) - pmid:18986241 + pmid:23038257 - p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072) + a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) - pmid:18986241 + pmid:23038257 - p(HGNC:NTRK1) biomarkerFor path(MESH:D000544) + a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) - pmid:18986241 + pmid:23038257 - p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) + a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) - - - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0038180") increases bp(GO:"GO:1990089") + a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) - - - - - pmid:18986241 + pmid:26813123 - complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) + a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) - pmid:18986241 + pmid:26813123 - bp(GO:"GO:1901214") association p(HGNC:NGFR) + act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") - pmid:18986241 + pmid:26813123 - a(MESHC:"pro-nerve growth factor, human") positiveCorrelation path(MESH:D003072) + a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:18986241 + pmid:26813123 - a(MESHC:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544) + act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) - - - - - pmid:18986241 + pmid:26813123 - complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") + act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) - pmid:18986241 + pmid:19721446 - bp(GO:"GO:0031175") association act(p(GFAM:"Mitogen-activated protein kinases")) + a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) - pmid:18986241 + pmid:23038257 - path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1) + a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) - - - pmid:18986241 - - path(MESH:D003072) positiveCorrelation a(MESHC:"pro-nerve growth factor, human") - + - - - pmid:18986241 - - path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9)) - + @@ -57749,30 +58407,15 @@

Statements

- - - pmid:18986241 - - complex(a(MESHC:"pro-nerve growth factor, human"), p(HGNC:NGFR)) increases bp(GO:"GO:0006915") - + - - - pmid:18986241 - - bp(GO:"GO:0006915") association bp(GO:"GO:0000165") - + - - - pmid:18986241 - - bp(MESH:D000375) increases p(HGNC:NGFR) - + @@ -57780,12 +58423,15 @@

Statements

- - - pmid:18986241 - - composite(a(MESHC:"pro-nerve growth factor, human"), complex(p(HGNC:NGFR), p(HGNC:SORT1))) increases bp(GO:"GO:0006915") - + + + + + + + + + @@ -57795,198 +58441,200 @@

Statements

- pmid:18986241 + pmid:23038257 - p(HGNC:SORT1) association path(MESH:D000544) + a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:18986241 + pmid:23038257 - act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072) + a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) + + - pmid:27594586 + pmid:28901280 - p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) + p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") - pmid:27594586 + pmid:28901280 - act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") + p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) - pmid:27594586 + pmid:28901280 - act(p(HGNC:MMP9)) increases bp(GO:"neuron death") + p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) - pmid:27594586 + pmid:28901280 - p(HGNC:MMP9) increases bp(GO:"neuron death") + p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) - pmid:27594586 + pmid:28901280 - act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) - pmid:27594586 + pmid:28901280 - sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) + p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) - pmid:29626319 + pmid:28901280 - act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta")) + p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") - pmid:29626319 + pmid:28901280 - p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta")) + p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation") - pmid:18986241 + pmid:28901280 - g(HGNC:NTRK1) association path(MESH:D003071) + p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") - pmid:18986241 + pmid:28901280 - g(HGNC:NTRK2) association path(MESH:D003071) + p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") - pmid:18986241 + pmid:28901280 - g(HGNC:NTRK3) association path(MESH:D003071) + p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") association bp(GO:"GO:0006915") + p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") association bp(GO:"GO:0030182") + p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") increases act(p(FPLX:RAS)) + p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") increases act(p(FPLX:RAF)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") increases act(p(FPLX:MEK)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK)) + p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2)) + p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters) - pmid:18986241 + pmid:28901280 - bp(GO:"GO:0030182") association bp(GO:"GO:0000165") + p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters) - pmid:18986241 + pmid:23038257 - p(GFAM:"Mitogen-activated protein kinases", pmod(Ph)) increases act(p(GFAM:"Mitogen-activated protein kinases")) + p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) @@ -57995,754 +58643,641 @@

Statements

- pmid:18986241 + pmid:23038257 - act(p(GFAM:"Mitogen-activated protein kinases")) association bp(GO:"GO:0031175") + a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) - pmid:18986241 + pmid:19721446 - act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph)) + a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:18986241 + pmid:2833519 - act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph)) + a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) - - - - - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0014065") regulates bp(MESH:D002470) + a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0014065") association p(FPLX:RAS) + a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0014065") association p(HGNC:IRS1) + p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0014065") association p(HGNC:GAB1) + a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0043491") regulates bp(MESH:D002470) + a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") - pmid:18986241 + pmid:19721446 - bp(GO:"GO:0043491") association p(FPLX:RAS) + a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0043491") association p(HGNC:IRS1) + p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr)) - pmid:18986241 + pmid:23038257 - bp(GO:"GO:0043491") association p(HGNC:GAB1) + p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + + - pmid:18986241 + pmid:22040696 - p(HGNC:IRS1) association bp(GO:"GO:0014065") + p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") - pmid:18986241 + pmid:23038257 - p(HGNC:IRS1) association bp(GO:"GO:0043491") + p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin)) - pmid:18986241 + pmid:23038257 - p(HGNC:GAB1) association bp(GO:"GO:0014065") + p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) - pmid:18986241 + pmid:24511233 - p(HGNC:GAB1) association bp(GO:"GO:0043491") + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:24511233 - act(p(HGNC:PLCG1)) association bp(MESH:D018384) + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - - - pmid:18467332 + pmid:24511233 - p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - pmid:18986241 + pmid:24511233 - bp(MESH:D018384) association act(p(HGNC:PLCG1)) + path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) - pmid:18986241 + pmid:24590577 - bp(MESH:D018384) association path(MESH:D000375) + path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) - pmid:18986241 + pmid:22040696 - bp(MESH:D018384) association path(MESH:D009410) + path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) - pmid:18986241 + pmid:24511233 - path(MESH:D000375) association bp(MESH:D018384) + path(MESH:Hallucinations) association path(MESH:Schizophrenia) - pmid:18986241 + pmid:24511233 - path(MESH:D009410) association bp(MESH:D018384) + path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) - pmid:18986241 + pmid:19721446 - bp(GO:"GO:0006665") association act(p(HGNC:NGFR)) + path(MESH:Hallucinations) association path(MESH:Schizophrenia) - - - - - pmid:18986241 + pmid:24511233 - complex(a(MESHC:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(Ph)) + path(MESH:Delusions) association path(MESH:Schizophrenia) - pmid:18986241 + pmid:24511233 - a(MESHC:"gambogic amide") decreases bp(HBP:Excitotoxicity) + path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) - pmid:18986241 + pmid:19721446 - a(MESHC:"gambogic amide") increases bp(GO:"GO:0031175") + path(MESH:Delusions) association path(MESH:Schizophrenia) - pmid:18986241 + pmid:24511233 - p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") + p(HGNC:CHRM1) association bp(GO:cognition) - pmid:18986241 + pmid:24511233 - p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165") + act(p(HGNC:CHRM1)) increases bp(GO:cognition) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:18986241 + pmid:24590577 - path(MESH:D024801) association p(HGNC:CHRM1) + act(p(HGNC:CHRM1)) increases bp(GO:cognition) - pmid:18986241 + pmid:24511233 - path(MESH:D000686) association p(HGNC:CHRM1) + p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:D060825) + p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:D024801) + p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") + act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(MGI:Chrm1)) + p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) + act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) - pmid:18986241 + pmid:24511233 - a(MESHC:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(MGI:Gsk3b)) + act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha")) - pmid:26751493 + pmid:24590577 - r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") + act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") - pmid:18986241 + pmid:26813123 - p(GFAM:Synaptotagmins) association bp(GO:"GO:0031629") + act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") - pmid:18986241 + pmid:26813123 - p(GFAM:Synaptotagmins) association bp(GO:"GO:0007269") + act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") - pmid:18986241 + pmid:26813123 - bp(GO:"GO:0031629") association p(GFAM:Synaptotagmins) + act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) - pmid:18986241 + pmid:26813123 - bp(GO:"GO:0007269") association p(GFAM:Synaptotagmins) + act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta")) - pmid:18986241 + pmid:24590577 - bp(GO:"GO:0007269") association p(HGNC:NGF) + act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") - pmid:18986241 + pmid:26813123 - p(GFAM:"Protein phosphatase catalytic subunits") increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:18986241 + pmid:26813123 - act(p(GFAM:"Protein phosphatase catalytic subunits")) decreases bp(HBP:hyperphosphorylation) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:18986241 + pmid:24590577 - bp(HBP:hyperphosphorylation) association path(MESH:D016874) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - - - pmid:17493042 + pmid:24590577 - p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:23407988 + pmid:24590577 - p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - - - - - - - pmid:17493042 + pmid:26813123 - p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) + act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) - pmid:23407988 + pmid:24590577 - p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") + act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) - - - - - - - - - pmid:17493042 + pmid:24590577 - p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) + p(HGNC:CHRM1) association a(MESH:Hippocampus) - pmid:23407988 + pmid:24590577 - p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau") + p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") - - - - - - - - - - - pmid:17493042 + pmid:24590577 - p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) + p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") - pmid:23407988 + pmid:24590577 - p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau") + p(HGNC:CHRM1) association a(MESH:Thalamus) - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:29191965 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") + p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") - pmid:29191965 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") + p(HGNC:CHRM1) association bp(GO:learning) - pmid:25374103 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") + p(HGNC:CHRM1) association bp(GO:memory) - pmid:25374103 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") positiveCorrelation act(p(HGNC:CASP3)) + p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") - pmid:25374103 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:CHRM1) association bp(GO:"neuron differentiation") - pmid:25374103 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") - pmid:17493042 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) + act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") - - - - - - - - - - - pmid:23407988 + pmid:24590577 - p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau") + act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") - - - - - + + + pmid:24590577 + + act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) + - pmid:30145931 + pmid:24590577 - r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) + p(HGNC:CHRM1) regulates p(HGNC:BACE1) - pmid:27574109 + pmid:24590577 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") - pmid:27574109 + pmid:24590577 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) - pmid:27574109 + pmid:24590577 - a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") + act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") - pmid:27574109 + pmid:24590577 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:27574109 + pmid:24590577 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") + act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") - pmid:18986241 + pmid:24590577 - act(p(HGNC:GAL)) association path(MESH:D003071) + act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") - pmid:18986241 + pmid:24590577 - act(p(HGNC:GAL)) association bp(MESH:D009473) + act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) - pmid:18986241 + pmid:24590577 - act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") + act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") @@ -58751,7 +59286,7 @@

Statements

pmid:18986241 - act(p(HGNC:GAL)) regulates act(a(MESH:D059329)) + p(HGNC:CHRM1) association path(MESH:D060825) @@ -58760,7 +59295,7 @@

Statements

pmid:18986241 - act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRM1) association path(MESH:D024801) @@ -58769,223 +59304,227 @@

Statements

pmid:18986241 - act(p(HGNC:GAL)) increases r(HGNC:CHAT) + p(HGNC:CHRM1) association path(MESH:D000686) - pmid:18986241 + pmid:26813123 - act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423") + p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:18986241 + pmid:26813123 - act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) + act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") - pmid:18986241 + pmid:24590577 - act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) + p(HGNC:CHRM2) association a(MESH:Hippocampus) - pmid:18986241 + pmid:24590577 - bp(MESH:D009473) association act(p(HGNC:GAL)) + p(HGNC:CHRM2) association a(MESH:Neocortex) - pmid:18986241 + pmid:24590577 - a(HBP:"Tau C3") biomarkerFor path(MESH:D059329) + p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) - pmid:18986241 + pmid:24590577 - p(RGD:Ngf) increases r(RGD:Gal) + p(HGNC:CHRM3) association a(MESH:Hypothalamus) - pmid:18986241 + pmid:24590577 - p(RGD:Ngf) decreases path(MESH:D060825) + p(HGNC:CHRM3) association a(MESH:Hippocampus) - pmid:18986241 + pmid:24511233 - bp(GO:"GO:0050435") association a(MESH:D002800) + p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") - pmid:18986241 + pmid:24511233 - path(MESH:D007319) association a(MESH:D002800) + p(HGNC:CHRM4) association a(MESH:Hippocampus) - pmid:18986241 + pmid:24511233 - path(MESH:D003967) association a(MESH:D002800) + p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") - pmid:18986241 + pmid:24590577 - path(MESH:D009325) association a(MESH:D002800) + p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") - pmid:18986241 + pmid:24511233 - path(MESH:D005221) association a(MESH:D002800) + p(HGNC:CHRM4) association a(MESH:Neocortex) - pmid:18986241 + pmid:24511233 - path(MESH:D000855) association a(MESH:D002800) + p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:18986241 + pmid:24511233 - bp(GO:"GO:0048485") association p(HGNC:NGF) + act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") - pmid:18986241 + pmid:24590577 - path(MESH:D002100) association p(HGNC:NGF) + p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") - pmid:18986241 + pmid:24590577 - path(MESH:D006930) association p(HGNC:NGF) + p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") - pmid:18986241 + pmid:24590577 - g(HGNC:NGF) directlyIncreases p(HGNC:NGF) + p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) - pmid:18986241 + pmid:24590577 - a(MESHC:latrepirdine) decreases act(p(HGNC:BCHE)) + p(HGNC:CHRM5) association a(MESH:"Pars Compacta") - pmid:18986241 + pmid:24590577 - a(MESHC:latrepirdine) decreases act(p(HGNC:ACHE)) + p(HGNC:CHRM5) increases bp(GO:"response to drug") - pmid:18986241 + pmid:24590577 - a(MESHC:latrepirdine) decreases bp(GO:"GO:0098989") + p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) - pmid:18986241 + pmid:24590577 - a(MESHC:latrepirdine) decreases bp(GO:"GO:0046902") + p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) + + + + - pmid:18986241 + pmid:24511233 - a(MESHC:latrepirdine) increases bp(MESH:D000066829) + complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") - pmid:11230871 + pmid:24511233 - a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) + complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") - pmid:11230871 + pmid:26088141 - path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) + p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) @@ -58994,11 +59533,21 @@

Statements

- + + + pmid:24511233 + + complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + - + + + pmid:24511233 + + complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + @@ -59008,1331 +59557,1303 @@

Statements

- pmid:11230871 + pmid:24511233 - a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") + complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") - pmid:11230871 + pmid:24511233 - a(PUBCHEM:132228) increases p(FPLX:CHRN) + complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") - - - pmid:11230871 - - a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) - + - pmid:11230871 + pmid:24511233 - a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") + complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:11230871 + pmid:26088141 - a(PUBCHEM:119380) increases bp(GO:memory) + p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) + + + + - pmid:28132910 + pmid:24511233 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:28132910 + pmid:17009926 - a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:Depression) association p(FPLX:CHRN) - pmid:28132910 + pmid:11230871 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:Depression) association p(FPLX:CHRN) - pmid:28132910 + pmid:26813123 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28132910 + pmid:21482353 - a(HBP:"B-973") increases act(a(CHEBI:acetylcholine)) + path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") - pmid:28132910 + pmid:19721446 - a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) + path(MESH:Depression) increases a(CHEBI:choline) - pmid:28132910 + pmid:28901280 - a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") - pmid:28132910 + pmid:27314526 - a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) + bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) - - - - - - - - - - - - - pmid:28132910 + pmid:24511233 - a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) - - - - - pmid:17640819 + pmid:24511233 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta") + a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") - - - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") - pmid:25881725 + pmid:24511233 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") - pmid:25881725 + pmid:17009926 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") - pmid:25881725 + pmid:17009926 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) - pmid:25881725 + pmid:17009926 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) - pmid:19721446 + pmid:17009926 - a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) - pmid:19721446 + pmid:24511233 - a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") - pmid:19721446 + pmid:24511233 - bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) + a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:19721446 + pmid:24590577 - p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:19721446 + pmid:24511233 - p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) + a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:19721446 + pmid:24511233 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) + a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) - pmid:19721446 + pmid:24590577 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) + a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:19721446 + pmid:29626319 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) + a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:29626319 - p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:19721446 + pmid:29626319 - p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) + a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19721446 + pmid:24511233 - p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) + path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) + path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) + path(MESH:Attention) association path(MESH:Schizophrenia) - pmid:19721446 + pmid:17009926 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) + path(MESH:Attention) association p(FPLX:CHRN) - pmid:19721446 + pmid:26813123 - p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) + path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") - pmid:19721446 + pmid:24590577 - p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) + path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:19721446 + pmid:25514383 - p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) + path(MESH:Attention) association a(HP:"cholinergic neuron") - pmid:19721446 + pmid:24511233 - p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) + path(MESH:"Executive Function") association path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) + a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) - pmid:19721446 + pmid:24511233 - a(MESH:"AR-R 17779") increases bp(GO:learning) + a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) - pmid:19721446 + pmid:24511233 - a(MESH:"AR-R 17779") increases bp(GO:memory) + bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:19721446 + pmid:26813123 - a(DRUGBANK:Facinicline) increases bp(GO:cognition) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:19721446 + pmid:24590577 - a(DRUGBANK:Facinicline) increases bp(GO:memory) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:19721446 + pmid:24511233 - a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") + a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) - pmid:19721446 + pmid:26813123 - a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity) + a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) - pmid:19721446 + pmid:24511233 - a(MESH:"Entorhinal Cortex") association bp(GO:memory) + a(CHEBI:xanomeline) decreases path(MESH:Delusions) - pmid:19721446 + pmid:24511233 - path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") + a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) - pmid:19721446 + pmid:24511233 - path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) + a(CHEBI:xanomeline) increases bp(GO:learning) - pmid:19721446 + pmid:24511233 - a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") + a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") - pmid:19721446 + pmid:24511233 - bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") - pmid:19721446 + pmid:26813123 - bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) + a(CHEBI:xanomeline) increases bp(GO:memory) - pmid:19721446 + pmid:24590577 - a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") + a(CHEBI:xanomeline) increases bp(GO:memory) - pmid:19721446 + pmid:26813123 - a(CHEBI:clozapine) association p(HGNC:CHRNA7) + a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") - pmid:19721446 + pmid:26813123 - a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) + a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") - pmid:19721446 + pmid:24590577 - a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") + a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") - pmid:19721446 + pmid:24590577 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) + a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) - pmid:28901280 + pmid:24511233 - a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic") + act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) - pmid:28901280 + pmid:24511233 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine)) + p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta")) - pmid:19721446 + pmid:24590577 - a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") + p(MGI:Chrm1) increases bp(GO:cognition) - pmid:19721446 + pmid:24590577 - a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") - pmid:19721446 + pmid:24590577 - a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) + act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing") - - - - - - - - - pmid:19721446 + pmid:24590577 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") - - - - - - - pmid:19721446 + pmid:18986241 - complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) - - - - - pmid:19721446 + pmid:24511233 - complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) - pmid:19721446 + pmid:24590577 - g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") - pmid:19721446 + pmid:24511233 - g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - path(MESH:Recurrence) association p(HGNC:CHRNA3) + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - path(MESH:Recurrence) association p(HGNC:CHRNB4) + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) - pmid:19721446 + pmid:24511233 - a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24511233 - a(CHEBI:sertraline) decreases a(CHEBI:monoamine) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) - pmid:19721446 + pmid:24511233 - a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:24590577 - a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") - pmid:19721446 + pmid:24590577 - a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") - pmid:19721446 + pmid:24511233 - a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) + act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") - pmid:19721446 + pmid:24511233 - a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) - pmid:19721446 + pmid:24511233 - a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) + a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) - pmid:19721446 + pmid:24511233 - a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:VU0357017) increases bp(GO:"behavioral fear response") - pmid:19721446 + pmid:24590577 - a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) + a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24590577 - a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") - pmid:19721446 + pmid:24590577 - a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) + a(MESH:VU0357017) increases bp(GO:learning) + + + + - pmid:19721446 + pmid:24511233 - a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) + + + + - pmid:19721446 + pmid:24511233 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) - pmid:19721446 + pmid:24511233 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) - pmid:19721446 + pmid:24511233 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") - pmid:19721446 + pmid:24511233 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) - pmid:19721446 + pmid:24511233 - a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") - - - - - pmid:19721446 + pmid:24511233 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) - pmid:19721446 + pmid:24590577 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) - pmid:28901280 + pmid:24511233 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) - pmid:28901280 + pmid:24590577 - path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) - pmid:22040696 + pmid:24590577 - p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing") - pmid:22040696 + pmid:24511233 - p(FPLX:"p14_3_3") increases p(FPLX:CHRN) + a(MESH:"Prefrontal Cortex") association bp(GO:cognition) - pmid:22040696 + pmid:24511233 - p(HGNC:HSPA5) increases p(FPLX:CHRN) + a(MESH:"Prefrontal Cortex") association bp(GO:learning) - pmid:22040696 + pmid:24511233 - p(HGNC:CANX) increases p(FPLX:CHRN) + a(MESH:"Prefrontal Cortex") association bp(GO:memory) - pmid:22040696 + pmid:26195256 - complex(GO:"proteasome complex") regulates p(FPLX:CHRN) + a(MESH:"Prefrontal Cortex") association path(MESH:"Alzheimer Disease") - pmid:22040696 + pmid:24511233 - complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") + a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) - pmid:22040696 + pmid:24511233 - complex(GO:"proteasome complex") regulates p(HGNC:RIC3) + a(HBP:VU0456940) increases act(p(HGNC:CHRM1)) - pmid:29758300 + pmid:24511233 - complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(Ph)) + a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) - pmid:29758300 + pmid:24511233 - complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) + a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") - pmid:14556719 + pmid:24511233 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) + act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") - pmid:14556719 + pmid:24511233 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) + act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") - pmid:14556719 + pmid:24511233 - complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) + path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) - pmid:14556719 + pmid:24511233 - complex(GO:"proteasome complex") increases a(CHEBI:peptide) + a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) - + + + pmid:24590577 + + a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) + - pmid:14556719 + pmid:24590577 - complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) - pmid:14556719 + pmid:24762290 - complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:22908190 + pmid:24511233 - act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Neocortex) association p(HGNC:CHRM4) - pmid:14556719 + pmid:24590577 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + a(MESH:Neocortex) association p(HGNC:CHRM2) - pmid:22908190 + pmid:24511233 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + a(HBP:VU10010) increases act(a(CHEBI:acetylcholine)) - pmid:22908190 + pmid:24511233 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + a(HBP:VU10010) increases act(p(HGNC:CHRM4)) - pmid:14556719 + pmid:24511233 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) + a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine)) - pmid:14556719 + pmid:29191965 - act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) + bp(GO:locomotion) positiveCorrelation a(CHEBI:"methylene blue") - pmid:18930136 + pmid:29191965 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) + bp(GO:locomotion) positiveCorrelation a(PUBCHEM:6475963) - pmid:14556719 + pmid:29191965 - act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) + bp(GO:locomotion) positiveCorrelation a(HBP:"Phenylthiazolyl-hydrazide") - pmid:22908190 + pmid:24511233 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(Ub))) + a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) - pmid:22908190 + pmid:28445721 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(UbK48))) + bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) - pmid:22908190 + pmid:21787755 - act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"paired helical filaments") + bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") - pmid:22908190 + pmid:17009926 - act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") + bp(GO:"developmental process") association p(FPLX:CHRN) - pmid:22908190 + pmid:17009926 - act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:22908190 + pmid:17009926 - complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(Ub))) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:22908190 + pmid:11230871 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:22908190 + pmid:21482353 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) + path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) - pmid:22908190 + pmid:21482353 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) + path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) - pmid:30116051 + pmid:21787755 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) + path(MESH:Epilepsy) association a(HBP:AβOs) - pmid:26751493 + pmid:28901280 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) + path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") - pmid:17954934 + pmid:17009926 - act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) + path(MESH:"Autistic Disorder") association p(FPLX:CHRN) - pmid:24457024 + pmid:17009926 - complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) - pmid:18930136 + pmid:17009926 - act(complex(GO:"proteasome complex")) decreases path(HBP:Neurodegeneration) + path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) - pmid:18930136 + pmid:30106381 - act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) + path(MESH:"Autistic Disorder") association p(HGNC:ADNP) - pmid:17954934 + pmid:30106381 - act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") + path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) - pmid:17954934 + pmid:26472524 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) + tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") - pmid:19732809 + pmid:17009926 - act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"O-GlcNAcylation") + p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:19732809 + pmid:17009926 - act(complex(GO:"proteasome complex")) positiveCorrelation g(HGNC:OGT) + p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:26041011 + pmid:17009926 - act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:26692334 + pmid:17009926 - act(complex(GO:"proteasome complex")) positiveCorrelation act(p(FPLX:PKA)) + p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) @@ -60347,11 +60868,21 @@

Statements

- + + + pmid:17009926 + + composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) + - + + + pmid:17009926 + + a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) + @@ -60361,9 +60892,9 @@

Statements

- pmid:22040696 + pmid:17009926 - composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A)) + composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) @@ -60372,476 +60903,461 @@

Statements

- - - pmid:22040696 + pmid:17009926 - p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) + composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) - pmid:22040696 + pmid:17009926 - p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN)) + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) - - - - - pmid:22040696 + pmid:28132910 - complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) - - - - - pmid:22040696 + pmid:28132910 - complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) - - - - - pmid:22040696 + pmid:17009926 - complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine)) - - - - - pmid:22040696 + pmid:17009926 - complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine)) - pmid:22040696 + pmid:17009926 - p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline)) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin)) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) regulates bp(GO:"central nervous system development") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)")) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) association p(HGNC:CHRNA7) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) - pmid:22040696 + pmid:17009926 - p(HGNC:BDNF) increases p(HGNC:CHRNA7) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) - pmid:22040696 + pmid:19323834 - p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) + a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) - pmid:28632203 + pmid:17009926 - p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") + a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:21787755 + pmid:17009926 - bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") + bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) - pmid:22040696 + pmid:17009926 - act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) + act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") - pmid:22040696 + pmid:17009926 - act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7)) + bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) - pmid:22040696 + pmid:17009926 - p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7)) + bp(GO:"action potential") increases sec(a(CHEBI:dopamine)) - pmid:22040696 + pmid:17009926 - p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7)) + path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) - pmid:22040696 + pmid:17009926 - p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) + path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) - pmid:22040696 + pmid:27075649 - r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) + path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016) - pmid:22040696 + pmid:17009926 - r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") + bp(GO:"response to pain") association p(FPLX:CHRN) - pmid:22040696 + pmid:17009926 - path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) + a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) - pmid:22040696 + pmid:17009926 - path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) + a(PUBCHEM:5311278) decreases bp(GO:memory) - pmid:22040696 + pmid:25514383 - bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") + a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - - - - - pmid:18174175 + pmid:26813123 - complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) + p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") - - - - - pmid:26837465 + pmid:26813123 - p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + p(FPLX:CHRM) regulates a(MESH:"Ion Channels") - pmid:26837465 + pmid:26813123 - p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) - pmid:26837465 + pmid:26813123 - p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) - - - - - pmid:21787755 + pmid:26813123 - bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") + act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) - + + + pmid:26813123 + + p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) + - pmid:21787755 + pmid:26813123 - a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") + act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") - pmid:21787755 + pmid:25514383 - a(HBP:AβOs) association path(MESH:"Alzheimer Disease") + p(FPLX:CHRM) regulates bp(GO:cognition) - pmid:21787755 + pmid:17009926 - a(HBP:AβOs) association path(MESH:Epilepsy) + p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) - pmid:22908190 + pmid:17009926 - a(HBP:AβOs) decreases act(a(GO:synapse)) + g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:22908190 + pmid:17009926 - a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation") + path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) - pmid:22908190 + pmid:17009926 - a(HBP:AβOs) decreases bp(GO:learning) + path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) - pmid:22908190 + pmid:17009926 - a(HBP:AβOs) decreases bp(GO:memory) + g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:22908190 + pmid:28445721 - a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") + path(MESH:Arousal) association p(FPLX:CHRN) - pmid:22908190 + pmid:28901280 - a(HBP:AβOs) decreases bp(GO:"L-glutamate import") + path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") - pmid:22908190 + pmid:23702978 - a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") - pmid:22908190 + pmid:23702978 - a(HBP:AβOs) increases deg(a(MESH:Neurites)) + a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:22908190 + pmid:23702978 - a(HBP:AβOs) decreases act(complex(GO:"proteasome complex")) + a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:28528849 + pmid:23702978 - a(HBP:AβOs) decreases a(MESH:"Dendritic Spines") + a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) - + + + pmid:23702978 + + a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) + - pmid:21787755 + pmid:24561250 - a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") + a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) - + + + pmid:26472524 + + act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") + - pmid:21787755 + pmid:26751493 - path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") + p(MESH:"Receptors, N-Methyl-D-Aspartate") association a(HBP:"projection domain") @@ -60850,541 +61366,529 @@

Statements

- - - pmid:21787755 - - a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) - + - pmid:21787755 + pmid:16820021 - a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) + a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") - pmid:21787755 + pmid:16820021 - a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) + a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) - pmid:21787755 + pmid:16820021 - a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + a(MESH:antalarmin) increases p(RGD:Drd2) - pmid:21787755 + pmid:16820021 - a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") + a(MESH:antalarmin) decreases p(RGD:Drd2) - pmid:21787755 + pmid:16820021 - a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") + a(MESH:antalarmin) increases p(RGD:Drd3) - pmid:21787755 + pmid:16820021 - path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") + a(MESH:antalarmin) decreases p(RGD:Drd3) - pmid:21787755 + pmid:16820021 - path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") + a(MESH:antalarmin) decreases path(HBP:"isolation rearing") - pmid:21787755 + pmid:16820021 - path(MESH:Reward) association r(HGNC:CHRNA6) + a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") - pmid:21787755 + pmid:16820021 - path(MESH:Reward) association p(HGNC:CHRNA6) + a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") - pmid:28901280 + pmid:16820021 - path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") + a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) - pmid:21787755 + pmid:16820021 - path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") + a(MESH:antalarmin) decreases r(RGD:Ntrk2) - pmid:21787755 + pmid:16820021 - a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + a(MESH:antalarmin) increases r(RGD:Ntrk2) - pmid:21787755 + pmid:29807032 - a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) + a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") - pmid:21787755 + pmid:29807032 - a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) - pmid:21787755 + pmid:29807032 - a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) + a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") - pmid:21787755 + pmid:23211705 - bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) + a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") - pmid:21787755 + pmid:23211705 - bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) + a(MESH:antalarmin) increases a(MESH:Morula) - - - - - pmid:28901280 + pmid:23211705 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) + a(MESH:antalarmin) increases a(MESH:Blastocyst) - pmid:28901280 + pmid:23211705 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(MESH:antalarmin) decreases act(p(MGI:Crh)) - pmid:28901280 + pmid:23211705 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(MESH:antalarmin) decreases act(p(MGI:Crh)) - pmid:28901280 + pmid:23211705 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + a(MESH:antalarmin) decreases act(p(MGI:Crh)) - pmid:28901280 + pmid:23211705 - a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") + a(MESH:antalarmin) decreases act(p(MGI:Crh)) - pmid:28901280 + pmid:23211705 - a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation") + a(MESH:antalarmin) regulates p(MGI:Crh) - - - pmid:28901280 - - a(MESH:Acetylcholine) association bp(GO:"cell adhesion") - + + + + + - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") + path(HBP:"isolation rearing") increases p(RGD:Drd2) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(GO:"secretion by cell") + path(HBP:"isolation rearing") increases p(RGD:Drd2) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") + path(HBP:"isolation rearing") increases p(RGD:Drd3) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(MESH:Apoptosis) + path(HBP:"isolation rearing") increases p(RGD:Drd3) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") + path(HBP:"isolation rearing") decreases r(RGD:Bdnf) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") + path(HBP:"isolation rearing") increases r(RGD:Bdnf) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling") + path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) - pmid:28901280 + pmid:16820021 - a(MESH:Acetylcholine) decreases path(MESH:Inflammation) + path(HBP:"isolation rearing") increases r(RGD:Ntrk2) - pmid:28901280 + pmid:11230871 - a(MESH:Acetylcholine) increases path(MESH:Neoplasms) + a(CHEBI:neurotransmitter) association bp(GO:cognition) - pmid:28901280 + pmid:14556719 - a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) - pmid:28901280 + pmid:26813123 - a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) + bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") - - - - - pmid:28901280 + pmid:26813123 - complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) + bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) - pmid:28901280 + pmid:24563850 - a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") - pmid:28901280 + pmid:24563850 - a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph)) - pmid:28901280 + pmid:24563850 - a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) - pmid:28901280 + pmid:24563850 - a(MESH:Nicotine) decreases a(MESH:Neurons) + bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic") + bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") + bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) + bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") - pmid:28901280 + pmid:21482353 - a(MESH:Nicotine) increases a(MESH:Glutamates) + bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") - pmid:28901280 + pmid:24590577 - a(MESH:Nicotine) increases a(MESH:Glutamates) + bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases bp(GO:"action potential initiation") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) + + - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases a(MESH:Dopamine) + p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases a(MESH:Dopamine) + a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) + a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) + p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate") + p(MGI:Slc18a3) increases bp(GO:cognition) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") + a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) - pmid:28901280 + pmid:26813123 - act(a(MESH:Nicotine)) association g(DNSNP:rs16969968) + a(CHEBI:antidote) increases act(p(HGNC:ACHE)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) increases path(MESH:Neoplasms) + a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) - pmid:28901280 + pmid:26813123 - a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) + p(MGI:Slc5a7) decreases path(MESH:Death) @@ -61395,108 +61899,102 @@

Statements

- pmid:28901280 + pmid:26813123 - complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) + complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") - pmid:28901280 + pmid:26813123 - bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) + a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:28901280 + pmid:26813123 - bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine) + p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN)) - pmid:28901280 + pmid:26813123 - bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic") + a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph)) - - - pmid:28901280 - - bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) - + - pmid:28901280 + pmid:26813123 - bp(GO:"secretion by cell") association a(MESH:Acetylcholine) + complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - - - pmid:28901280 - - bp(MESH:Apoptosis) association a(MESH:Acetylcholine) - + - pmid:28901280 + pmid:26813123 - bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) + complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - pmid:28901280 + pmid:22020111 - bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) + a(CHEBI:cystine) increases a(CHEBI:glutathione) + + + + - pmid:28901280 + pmid:26813123 - bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine) + complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - pmid:28901280 + pmid:11230871 - a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) + complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) - pmid:28901280 + pmid:26813123 - a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") + a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) @@ -61505,59 +62003,66 @@

Statements

pmid:29626319 - a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta")) + + + + - pmid:29626319 + pmid:26813123 - a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) - pmid:28901280 + pmid:26813123 - a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") - pmid:28901280 + pmid:26813123 - a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) - pmid:28901280 + pmid:26813123 - path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") - pmid:28901280 + pmid:26813123 - bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") - - - + + + pmid:26813123 + + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) + @@ -61567,5523 +62072,5705 @@

Statements

- pmid:28901280 + pmid:26813123 - p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) - pmid:28901280 + pmid:26813123 - bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") - pmid:28901280 + pmid:26813123 - a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) - pmid:28901280 + pmid:26813123 - a(HBP:cytisine) decreases act(a(MESH:Nicotine)) + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + + + + - pmid:28901280 + pmid:26813123 - a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) - pmid:28901280 + pmid:26813123 - a(MESH:Carbachol) decreases act(a(MESH:Nicotine)) + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") - pmid:28901280 + pmid:26813123 - a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) - pmid:28901280 + pmid:26813123 - a(MESH:Varenicline) decreases act(a(MESH:Nicotine)) + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + + + + - pmid:28901280 + pmid:26813123 - a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic") + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) - pmid:28901280 + pmid:26813123 - a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine)) + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:28901280 + pmid:26813123 - a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) - - - pmid:28901280 - - a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) - + - pmid:28901280 + pmid:26813123 - a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) - pmid:28901280 + pmid:26813123 - a(MESH:Glutamates) increases bp(GO:"action potential initiation") + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:27796283 + pmid:26813123 - bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) + + - pmid:27041503 + pmid:26088141 - bp(MESH:"Long-Term Potentiation") negativeCorrelation bp(GO:"actin filament polymerization") + act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) - pmid:27041503 + pmid:26088141 - bp(MESH:"Long-Term Potentiation") negativeCorrelation p(HGNC:WWC1) + act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") + + + + - pmid:27041503 + pmid:26813123 - bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:memory) + complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) - pmid:28901280 + pmid:26813123 - bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic") + a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) - pmid:28901280 + pmid:26813123 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System")) + a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) - pmid:28901280 + pmid:25514383 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System")) + a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) - pmid:28901280 + pmid:26813123 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) + path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28901280 + pmid:26813123 - g(DNSNP:rs16969968) association act(a(MESH:Nicotine)) + p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:28901280 + pmid:24590577 - p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) + p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) - pmid:28901280 + pmid:24590577 - p(MGI:Chrna5) increases a(MESH:Nicotine) + p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") - pmid:28901280 + pmid:24590577 - p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) + p(MGI:Chrm4) decreases act(p(MGI:Drd1)) - pmid:28901280 + pmid:26813123 - p(MGI:Chrna2) increases a(MESH:Nicotine) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:28901280 + pmid:22020111 - a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates") - pmid:28901280 + pmid:12428809 - a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments") - pmid:28901280 + pmid:29758300 - a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) - pmid:28901280 + pmid:29758300 - p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic") + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) - - - - - - - - - pmid:28901280 + pmid:14556719 - g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") + path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") - pmid:28901280 + pmid:14556719 - g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") + path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") - pmid:28901280 + pmid:14556719 - bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) + path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") - pmid:28901280 + pmid:14556719 - a(MESH:Epithelium) regulates a(MESH:Acetylcholine) + path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) - pmid:28901280 + pmid:14556719 - act(a(MESH:Epithelium)) association p(MGI:Chrna7) + path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") - pmid:28901280 + pmid:14556719 - a(MESH:Choline) increases act(p(HGNC:CHRNA9)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) - pmid:28901280 + pmid:14556719 - a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) - pmid:28901280 + pmid:14556719 - a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) - pmid:28901280 + pmid:22908190 - a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) - pmid:28901280 + pmid:22908190 - a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) - pmid:28901280 + pmid:25784053 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) + path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) - pmid:28901280 + pmid:25784053 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) - pmid:28901280 + pmid:30116051 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) - - - pmid:23178521 + pmid:30116051 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) - pmid:23178521 + pmid:30116051 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) - pmid:23178521 + pmid:30116051 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) - pmid:23178521 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:23178521 + pmid:29758300 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) - pmid:23178521 + pmid:29311797 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") - pmid:23178521 + pmid:30126037 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) - pmid:23178521 + pmid:29191965 - a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response") + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) - pmid:23178521 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) - pmid:23178521 + pmid:28420982 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") - pmid:23383175 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") - pmid:23383175 + pmid:26751493 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") - pmid:23383175 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") - pmid:23383175 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132) - pmid:23383175 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) - pmid:23178521 + pmid:26631930 - a(CHEBI:Anatabine) decreases p(MGI:Tnf) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) - pmid:23383175 + pmid:12578227 - a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) + path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) - pmid:23383175 + pmid:12578227 - a(CHEBI:Anatabine) decreases p(MGI:Tnf) + path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) - pmid:23178521 + pmid:12578227 - a(CHEBI:Anatabine) decreases p(MGI:Il6) + path(MESH:"Supranuclear Palsy, Progressive") increases r(HBP:"TGM2 Isoform 3 (349 aa)") - pmid:23383175 + pmid:12578227 - a(CHEBI:Anatabine) decreases p(MGI:Il6) + path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) - pmid:23383175 + pmid:11089576 - a(CHEBI:Anatabine) decreases a(MESH:Cytokines) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) - pmid:23383175 + pmid:22057784 - a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) - pmid:23383175 + pmid:17050703 - a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:23383175 + pmid:29281045 - a(CHEBI:Anatabine) decreases path(MESH:Paralysis) + path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) - pmid:23383175 + pmid:29281045 - a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") + path(MESH:"Supranuclear Palsy, Progressive") increases p(ECCODE:"3.1.1.89") - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Il1b) + path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Il1b) + act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers") + + + + - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Il17a) + complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils") - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Il17a) + p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) + p(MGI:App, var("?")) decreases p(FPLX:CHRM) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Ifng) + p(MGI:App, var("?")) decreases p(FPLX:CHRN) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) + a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) + a(PUBCHEM:10013505) increases bp(GO:cognition) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) + a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) + a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) - pmid:23383175 + pmid:26813123 - a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) + a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") - pmid:23383175 + pmid:24653673 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) - pmid:23383175 + pmid:30116051 - a(CHEBI:Anatabine) decreases a(MESH:Microglia) + p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) - pmid:23383175 + pmid:30116051 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") - pmid:23383175 + pmid:29215007 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23383175 + pmid:29988016 - a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") + p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") - pmid:23178521 + pmid:21882945 - a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) + p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") - pmid:23178521 + pmid:26631930 - a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) + p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") - pmid:23178521 + pmid:21882945 - a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) + p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:23178521 + pmid:26631930 - a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) + p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - - - pmid:23178521 + pmid:26631930 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + a(PUBCHEM:9867750) increases bp(GO:cognition) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + a(PUBCHEM:1476756) increases bp(GO:memory) - pmid:23178521 + pmid:24027553 - a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) + a(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) - pmid:23178521 + pmid:25899010 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + a(HBP:Excitotoxicity) positiveCorrelation p(HGNC:DAPK1) - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") - pmid:23178521 + pmid:26813123 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + a(MESH:"Nerve Growth Factor") increases bp(GO:memory) - pmid:23178521 + pmid:11230871 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) - pmid:23178521 + pmid:16273023 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + path(MESH:D000544) association path(MESH:D016874) - pmid:23178521 + pmid:18986241 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(MESH:D000544) increases path(MESH:D016874) - pmid:23178521 + pmid:16273023 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(MESH:D000544) association path(MESH:D058225) - pmid:23178521 + pmid:16273023 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(MESH:D000544) association bp(GO:"GO:0070997") - pmid:23178521 + pmid:16273023 - a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) decreases bp(MESH:D009435) - - - - - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) + path(MESH:D000544) decreases bp(GO:"GO:0007271") - - - - - - - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) + path(MESH:D000544) decreases bp(GO:"GO:0035249") - pmid:23383175 + pmid:16273023 - p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat)) - pmid:23383175 + pmid:18986241 - p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) decreases p(HGNC:CHAT) - pmid:23383175 + pmid:16273023 - p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) decreases bp(GO:"GO:0015871") - - - - - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + path(MESH:D000544) decreases bp(GO:"GO:0008292") - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + path(MESH:D000544) causesNoChange p(MESH:D011950) - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + path(MESH:D000544) decreases bp(GO:"GO:0051935") - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + path(MESH:D000544) decreases bp(GO:"GO:0014047") - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + path(MESH:D000544) decreases bp(GO:"GO:0014047") - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + path(MESH:D000544) decreases bp(MESH:D017774) - pmid:23178521 + pmid:16273023 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + path(MESH:D000544) decreases bp(MESH:D017774) - pmid:23383175 + pmid:16273023 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:23383175 + pmid:18986241 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) association path(MESH:D019636) - pmid:23383175 + pmid:18986241 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) association path(MESH:D008568) - pmid:23383175 + pmid:18986241 - p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") + path(MESH:D000544) association path(MESH:D003071) - pmid:23383175 + pmid:18986241 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) + path(MESH:D000544) association path(MESH:D001526) - - - pmid:23383175 + pmid:18986241 - p(MGI:Stat3) regulates bp(GO:"cytokine production") + path(MESH:D000544) association path(HBP:aMCI) - pmid:23383175 + pmid:18986241 - act(a(GO:axon)) decreases path(MESH:Paralysis) + path(MESH:D000544) decreases a(MESH:D059329) - pmid:23383175 + pmid:18986241 - act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") + path(MESH:D000544) association a(MESH:D059329) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) + path(MESH:D000544) decreases a(MESH:D059329) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) + path(MESH:D000544) association a(MESH:D016874) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Il1b) + path(MESH:D000544) decreases p(HGNC:ACHE) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) + path(MESH:D000544) causesNoChange act(p(HGNC:ACHE)) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Ifng) + path(MESH:D000544) decreases act(p(HGNC:ACHE)) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) + path(MESH:D000544) decreases act(p(HGNC:ACHE)) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Tnf) + path(MESH:D000544) increases act(p(HGNC:BCHE)) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) + path(MESH:D000544) causesNoChange p(HGNC:SLC18A3) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) + path(MESH:D000544) increases path(MESH:D001284) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) decreases p(HGNC:NTRK1) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) increases p(HGNC:NGF) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) association p(HGNC:SORT1) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) decreases bp(GO:"GO:0032455") - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) increases act(p(HGNC:MMP9)) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) decreases g(HGNC:NTRK1) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) decreases g(HGNC:NTRK2) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) + path(MESH:D000544) decreases g(HGNC:NTRK3) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) + path(MESH:D000544) increases g(HGNC:NGFR) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) + path(MESH:D000544) causesNoChange r(HGNC:CHAT) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) + path(MESH:D000544) increases r(HGNC:CHRNA7) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + path(MESH:D000544) increases r(HGNC:CHRNA7) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) increases a(MESH:Microglia) + path(MESH:D000544) causesNoChange r(HGNC:CHRM1) - pmid:23383175 + pmid:18986241 - path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") + path(MESH:D000544) decreases r(HGNC:SYP) - pmid:23383175 + pmid:18986241 - p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) causesNoChange r(HGNC:VAMP1) - pmid:23383175 + pmid:18986241 - p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:D000544) causesNoChange r(HGNC:SNAP29) - pmid:23383175 + pmid:18986241 - p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) causesNoChange r(HGNC:APP) - - - pmid:23383175 + pmid:18986241 - p(MGI:Rela) regulates bp(GO:"cytokine production") + path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) - pmid:23383175 + pmid:18986241 - path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) + path(MESH:D000544) increases r(HGNC:CTSD) - pmid:23383175 + pmid:18986241 - bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") + path(MESH:D000544) decreases r(HGNC:PPP1CA) - pmid:23383175 + pmid:18986241 - bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") + path(MESH:D000544) decreases r(HGNC:PPP1CC) - pmid:23383175 + pmid:18986241 - a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) + path(MESH:D000544) causesNoChange r(HGNC:MAPT) - pmid:23383175 + pmid:18986241 - a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) + path(MESH:D000544) decreases a(HBP:"3R tau") - pmid:23383175 + pmid:16273023 - a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) + path(MESH:D016874) association path(MESH:D000544) - pmid:23383175 + pmid:18986241 - a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) + path(MESH:D016874) association bp(HBP:hyperphosphorylation) - pmid:23383175 + pmid:16273023 - a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) + path(MESH:D058225) association path(MESH:D000544) - pmid:22020111 + pmid:18986241 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + path(MESH:D058225) association p(HGNC:BCHE) - pmid:22020111 + pmid:18986241 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + path(MESH:D058225) association p(HGNC:ACHE) - pmid:22020111 + pmid:16273023 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + bp(GO:"GO:0070997") association path(MESH:D000544) - pmid:22020111 + pmid:16273023 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + bp(GO:"GO:0070997") association act(p(MESH:D017470)) - - - pmid:22020111 + pmid:16273023 - act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") + bp(GO:"GO:0007271") association path(MESH:D003071) - pmid:22020111 + pmid:16273023 - act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + bp(GO:"GO:0007271") association path(MESH:D003071) - pmid:24563850 + pmid:16273023 - p(HGNC:NFE2L2) increases bp(HBP:Proteostasis) + bp(GO:"GO:0007271") association a(MESH:D002800) - pmid:29121589 + pmid:16273023 - p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + bp(GO:"GO:0035249") association path(MESH:D003071) - - - - - pmid:29121589 + pmid:16273023 - p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) + bp(GO:"GO:0035249") association path(MESH:D003071) - pmid:24355211 + pmid:16273023 - p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18") + bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + path(MESH:D003071) association bp(GO:"GO:0035249") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:NFE2L2) + path(MESH:D003071) association bp(GO:"GO:0035249") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + path(MESH:D003071) association bp(GO:"GO:0007271") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:SIRT1) + path(MESH:D003071) association bp(GO:"GO:0007271") - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) + path(MESH:D003071) association path(MESH:D000544) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:AKR1B10) + path(MESH:D003071) association p(HGNC:BCHE) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:PTGR1) + path(MESH:D003071) association g(HGNC:NTRK1) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + path(MESH:D003071) association g(HGNC:NTRK2) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + path(MESH:D003071) association g(HGNC:NTRK3) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:AIFM2) + path(MESH:D003071) association act(p(HGNC:GAL)) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:OSGIN1) + bp(GO:"GO:0008292") association path(MESH:D003704) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:GPX3) + path(MESH:D003704) association bp(GO:"GO:0008292") - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:SQSTM1) + path(MESH:D003704) association path(HBP:aMCI) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:HSPB8) + path(MESH:D003704) association a(MESH:D059329) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) increases p(HGNC:TNFSF9) + path(MESH:D003704) decreases p(HGNC:ACHE) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1) + path(MESH:D013850) association a(MESH:D006624) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:DHFR) + path(MESH:D013850) association a(MESH:D019579) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:DHFR) + path(MESH:D013850) association a(CHEBI:"glutamate(1-)") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:EDN1) + a(MESH:D006624) association path(MESH:D013850) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:ITGB3) + a(MESH:D006624) association path(MESH:D008568) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:MKI67) + a(MESH:D019579) association path(MESH:D013850) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:MMP11) + a(MESH:D019579) association path(MESH:D008568) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:MMP14) + path(MESH:D008568) association a(MESH:D006624) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:MMP2) + path(MESH:D008568) association a(MESH:D019579) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:PDE7A) + path(MESH:D008568) association a(CHEBI:"glutamate(1-)") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:PDE7B) + path(MESH:D008568) association bp(MESH:D017774) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:PLAU) + path(MESH:D008568) association path(MESH:D000544) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) + path(MESH:D008568) association a(MESH:D059329) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) + act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:SCARB1) + bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + bp(GO:"GO:0014047") increases bp(MESH:D017774) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + bp(GO:"GO:0051935") increases a(CHEBI:glutamine) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + a(CHEBI:glutamine) increases bp(GO:"GO:0006868") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:NR3C1) + act(p(MESH:D017470)) association bp(GO:"GO:0070997") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:NR3C1) + bp(MESH:D017774) association path(MESH:D008568) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:PPARA) + bp(MESH:D017774) association path(MESH:D007858) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:PPARA) + path(MESH:D007858) association bp(MESH:D017774) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:EGR1) + a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) + + + + - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:PTGS2) + composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:PTGS2) + a(MESH:D002800) increases bp(GO:"GO:0014047") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) increases p(HGNC:SOAT1) + a(MESH:D002800) increases bp(GO:"GO:0014047") - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:ACLY) + a(MESH:D002800) increases a(CHEBI:acetylcholine) - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:ACLY) + a(MESH:D002800) association bp(GO:"GO:0007271") - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1) + a(MESH:D002800) decreases path(MESH:D000544) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:C20orf27) + a(MESH:D002800) decreases a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:CCNA2) + a(MESH:D002800) increases bp(MESH:D000066829) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A) + a(MESH:D002800) association bp(GO:"GO:0050435") - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11) + a(MESH:D002800) association path(MESH:D007319) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:FEN1) + a(MESH:D002800) association path(MESH:D003967) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:GINS2) + a(MESH:D002800) association path(MESH:D009325) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:MCM10) + a(MESH:D002800) association path(MESH:D005221) - pmid:22020111 + pmid:18986241 - a(PUBCHEM:135316034) decreases p(HGNC:MCM4) + a(MESH:D002800) association path(MESH:D000855) + + - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A) + complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) + + - pmid:22020111 + pmid:16273023 - a(PUBCHEM:135316034) decreases p(HGNC:SLIT2) + a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + + + + + + + + - pmid:22020111 + pmid:24590577 - a(PUBCHEM:135316034) decreases p(HGNC:SPC25) + a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") - pmid:22020111 + pmid:24027553 - a(PUBCHEM:135316034) decreases p(HGNC:TFRC) + a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") - pmid:22020111 + pmid:28083634 - a(PUBCHEM:135316034) decreases p(HGNC:TK1) + a(HBP:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1) - pmid:22020111 + pmid:29758300 - a(PUBCHEM:135316034) decreases p(HGNC:TMEM97) + a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:22020111 + pmid:23528736 - a(PUBCHEM:135316034) decreases p(HGNC:TRIP13) + a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:22020111 + pmid:29758300 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB) + a(HBP:"Tau aggregates") association bp(GO:autophagy) - pmid:22020111 + pmid:29758300 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB) + a(HBP:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) - pmid:22020111 + pmid:22908190 - a(PUBCHEM:135316034) decreases p(HGNC:TYMS) + a(HBP:"Tau aggregates") increases p(HBP:"Tau aggregates", pmod(Ub)) - pmid:22020111 + pmid:22908190 - a(PUBCHEM:135316034) decreases p(HGNC:TYMS) + a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) - pmid:22020111 + pmid:24027553 - a(PUBCHEM:135316034) decreases p(HGNC:UBA1) + a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity) - pmid:22020111 + pmid:24027553 - a(PUBCHEM:135316034) decreases p(HGNC:UNG) + a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) - pmid:22020111 + pmid:24027553 - a(PUBCHEM:135316034) decreases p(HGNC:UNG) + a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) - pmid:22020111 + pmid:27574109 - a(PUBCHEM:135316034) decreases p(HGNC:VRK1) + a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) increases p(HGNC:ABCD3) + a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) increases p(HGNC:GLRX2) + a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) increases p(HGNC:GLRX2) + a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) increases p(HGNC:MICB) + a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22020111 + pmid:26751493 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:22020111 + pmid:26751493 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) decreases p(HGNC:AGRN) + a(HBP:"Tau aggregates") association a(GO:"early endosome") - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) + a(HBP:"Tau aggregates") association a(GO:"late endosome") - pmid:22020111 + pmid:29590627 - a(PUBCHEM:135316034) decreases p(HGNC:BAX) + a(HBP:"Tau aggregates") association a(GO:lysosome) - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:BCHE) + a(HBP:"Tau aggregates") increases path(HBP:proteotoxicity) - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:BGN) + a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:BRCA1) + a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CADPS2) + a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CAPN1) + a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CCNB1) + a(HBP:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CDK1) + a(HBP:"Tau aggregates") decreases p(UNIPROT:O02495) - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CDK2) + a(HBP:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") - pmid:22020111 + pmid:22611162 - a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A) + a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") - pmid:22020111 + pmid:28528849 - a(PUBCHEM:135316034) decreases p(HGNC:CXCR4) + a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") - pmid:22020111 + pmid:28528849 - a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1) + a(HBP:"Tau aggregates") causesNoChange a(GO:membrane) - pmid:22020111 + pmid:29988016 - a(PUBCHEM:135316034) decreases p(HGNC:FOLH1) + a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:27373205 - a(PUBCHEM:135316034) decreases p(HGNC:HOMER1) + a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:HRH1) + a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) decreases p(HGNC:IGF2) + a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:21882945 - a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2) + a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) - pmid:22020111 + pmid:29311797 - a(PUBCHEM:135316034) decreases p(HGNC:LDLR) + a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) - pmid:22020111 + pmid:30640040 - a(PUBCHEM:135316034) decreases p(HGNC:MAOA) + a(HBP:"Tau aggregates") increases bp(GO:"cell killing") - pmid:22020111 + pmid:29191965 - a(PUBCHEM:135316034) decreases p(HGNC:NEFH) + a(HBP:"Tau aggregates") decreases act(a(GO:synapse)) - pmid:22020111 + pmid:29191965 - a(PUBCHEM:135316034) decreases p(HGNC:NPDC1) + a(HBP:"Tau aggregates") decreases a(GO:presynapse) - pmid:22020111 + pmid:29191965 - a(PUBCHEM:135316034) decreases p(HGNC:NRGN) + a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:22020111 + pmid:25374103 - a(PUBCHEM:135316034) decreases p(HGNC:PREP) + a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") - pmid:22020111 + pmid:28420982 - a(PUBCHEM:135316034) decreases p(HGNC:PROS1) + a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") - pmid:22020111 + pmid:28877763 - a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1) + a(HBP:"Tau aggregates") association p(HGNC:SYK) - pmid:22020111 + pmid:28877763 - a(PUBCHEM:135316034) decreases p(HGNC:TAGLN) + a(HBP:"Tau aggregates") association p(HGNC:SYK) - pmid:22020111 + pmid:28877763 - a(PUBCHEM:135316034) decreases p(HGNC:TGFB1) + a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:SYK) - pmid:22020111 + pmid:28877763 - a(PUBCHEM:135316034) decreases p(HGNC:VKORC1) + a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:22020111 + pmid:28420982 - a(PUBCHEM:135316034) increases p(HGNC:CANX) + a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) increases p(HGNC:GCNT2) + a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) increases p(HGNC:IDE) + a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) increases p(HGNC:MMP1) + a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:22020111 + pmid:28420982 - a(PUBCHEM:135316034) increases p(HGNC:SLC6A6) + a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") - pmid:22020111 + pmid:28420982 - a(PUBCHEM:135316034) increases p(HGNC:SYVN1) + a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT)) - pmid:22020111 + pmid:28420982 - a(PUBCHEM:135316034) increases p(HGNC:TSHZ1) + a(HBP:"Tau aggregates") association a(CHEBI:dextran) - pmid:22020111 + pmid:29311797 - a(PUBCHEM:135316034) increases p(HGNC:TXN) + a(HBP:"Tau aggregates") association p(HGNC:HDAC6) - pmid:22020111 + pmid:29311797 - a(PUBCHEM:135316034) decreases p(HGNC:ATAD2) + a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:BECN1) + a(HBP:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:DHCR24) + a(HBP:"Tau aggregates") positiveCorrelation bp(GO:aging) - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:FGF2) + a(HBP:"Tau aggregates") decreases bp(GO:"microtubule polymerization") - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:HTRA1) + a(HBP:"Tau aggregates") decreases act(a(MESH:Neurons)) - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) decreases p(HGNC:PRKCE) + a(HBP:"Tau aggregates") increases path(HBP:Neurodegeneration) - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) decreases p(HGNC:PRKDC) + a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA)) - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) decreases p(HGNC:SCD) + a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A)) - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) increases p(HGNC:ATP1A1) + a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:22020111 + pmid:22817713 - a(PUBCHEM:135316034) increases p(HGNC:CTSD) + a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + - pmid:22020111 + pmid:25125464 - a(PUBCHEM:135316034) increases p(HGNC:GLRX) + a(HBP:"Tau aggregates") positiveCorrelation p(MGI:Crhr1) - pmid:22020111 + pmid:12428809 - a(PUBCHEM:135316034) increases p(HGNC:GLRX) + bp(GO:"axonal transport") association p(HGNC:MAPT) - pmid:22020111 + pmid:12428809 - a(PUBCHEM:135316034) increases p(HGNC:IL6R) + bp(GO:"axonal transport") association p(HGNC:APP) - pmid:22020111 + pmid:12428809 - a(PUBCHEM:135316034) increases p(HGNC:NPTX1) + bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:22908190 - a(PUBCHEM:135316034) increases p(HGNC:PHF1) + bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:12428809 - a(PUBCHEM:135316034) increases p(HGNC:PRKCD) + bp(GO:"axonal transport") association a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:12428809 - a(PUBCHEM:135316034) increases p(HGNC:RANBP9) + bp(GO:"axonal transport") association p(HGNC:GSK3B) - pmid:22020111 + pmid:26631930 - a(PUBCHEM:135316034) increases p(HGNC:SOD1) + bp(GO:"axonal transport") decreases path(HBP:Neurodegeneration) - pmid:22020111 + pmid:21734277 - a(PUBCHEM:135316034) increases p(HGNC:SOD1) + bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:PPP1CA)) + + + + + + - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") + + + + - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + + + + - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") + complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + + + + - pmid:22020111 + pmid:24590577 - a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:22020111 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + + + + - pmid:22020111 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") - pmid:22020111 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + + + + - pmid:22020111 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") - pmid:22020111 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:29121589 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK)) + path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:29121589 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38)) + a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:29121589 + pmid:29626319 - a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473)) + a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta")) - pmid:29121589 + pmid:29626319 - a(CHEBI:"dimethyl fumarate") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") - pmid:29121589 + pmid:29626319 - a(CHEBI:"dimethyl fumarate") decreases p(HGNC:MAPT, pmod(Ph)) + a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") - pmid:29121589 + pmid:29626319 - a(CHEBI:"dimethyl fumarate") negativeCorrelation p(HGNC:DPYSL2, pmod(Ph)) + a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:29121589 + pmid:29626319 - a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis) + a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:29121589 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis) + a(MESH:Thalamus) association p(HGNC:CHRM1) - pmid:29121589 + pmid:24762290 - a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) + a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:29121589 + pmid:24762290 - a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) + a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:29121589 + pmid:24590577 - a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") + p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") - pmid:22020111 + pmid:24590577 - p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac)) + a(MESH:Hypothalamus) association p(HGNC:CHRM3) - pmid:30116051 + pmid:24590577 - p(HGNC:SIRT1) increases bp(GO:macroautophagy) + p(MGI:Chrm3) regulates bp(GO:"response to food") - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) + p(MGI:Chrm3) increases bp(GO:"pituitary gland development") - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) + p(MGI:Chrm3) increases p(MGI:Prl) - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) + p(MGI:Chrm3) increases p(MGI:Gh) - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) + p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) + a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") - pmid:30116051 + pmid:24590577 - act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) + a(MESH:"Pars Compacta") association p(HGNC:CHRM5) - pmid:26631930 + pmid:22020111 - p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys)) + a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) - pmid:20869593 + pmid:24590577 - act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) - pmid:20869593 + pmid:24590577 - act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8") + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta") - pmid:29540553 + pmid:24590577 - act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:29540553 + pmid:24590577 - act(p(HGNC:SIRT1)) negativeCorrelation a(HBP:"Pathological Tau Spreading") + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:29540553 + pmid:24590577 - act(p(HGNC:SIRT1)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") - pmid:29540553 + pmid:24590577 - p(HGNC:SIRT1) positiveCorrelation bp(GO:learning) + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) - pmid:29540553 + pmid:24590577 - p(HGNC:SIRT1) positiveCorrelation bp(GO:memory) + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) - pmid:29226865 + pmid:24590577 - act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52)) + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22020111 + pmid:24401760 - a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) + p(MGI:Bace1) positiveCorrelation a(CHEBI:"amyloid-beta") + + - pmid:22020111 + pmid:24590577 - a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) + complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) + + - pmid:30116051 + pmid:29686391 - a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) + bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") - pmid:30116051 + pmid:24590577 - a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta") + bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) - pmid:30116051 + pmid:23454242 - a(CHEBI:resveratrol) decreases p(HGNC:HTT) + bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2) - pmid:30116051 + pmid:18494933 - a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) + bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:30116051 + pmid:24590577 - a(CHEBI:resveratrol) decreases act(p(HGNC:APP, frag("23_35"))) + a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) - pmid:30116051 + pmid:24027553 - a(CHEBI:resveratrol) increases r(FPLX:ATG4) + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:24027553 - a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:24027553 - a(CHEBI:resveratrol) decreases p(HGNC:AGER) + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:24027553 - a(CHEBI:resveratrol) decreases p(HGNC:MMP9) + act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:30116051 + pmid:24027553 - a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") - pmid:29062069 + pmid:24027553 - a(CHEBI:resveratrol) directlyIncreases act(p(HGNC:PPP2CA)) + act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:Inflammation) - pmid:29062069 + pmid:24027553 - a(CHEBI:resveratrol) directlyDecreases p(HGNC:MID1) + act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates") - pmid:22020111 + pmid:24590577 - p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) - pmid:22020111 + pmid:24590577 - p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) - pmid:22020111 + pmid:24590577 - p(HGNC:AKR1B10) increases bp(GO:detoxification) + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") + + + + - pmid:22020111 + pmid:24590577 - p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") - pmid:22020111 + pmid:24590577 - p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:24590577 - p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") - pmid:22020111 + pmid:24590577 - p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2)) + a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22020111 + pmid:24590577 - p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") - pmid:22020111 + pmid:24590577 - p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) + a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:24590577 - p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) + a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha") - pmid:22020111 + pmid:24590577 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + a(CHEBI:cevimeline) increases path(MESH:Confusion) - pmid:22908190 + pmid:24590577 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + a(CHEBI:cevimeline) increases path(MESH:Diarrhea) - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) regulates bp(GO:autophagy) + a(CHEBI:cevimeline) increases path(MESH:Asthenia) - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha") - pmid:22020111 + pmid:24590577 - p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") + a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta") - pmid:29758300 + pmid:24590577 - p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) + a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) - pmid:29758300 + pmid:24590577 - p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) - pmid:29758300 + pmid:24590577 - p(HGNC:SQSTM1) increases p(HGNC:SYP) + a(MESH:"WAY 132983") increases bp(GO:cognition) - pmid:29758300 + pmid:24590577 - p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") + a(MESH:"WAY 132983") increases path(MESH:Salivation) - pmid:22908190 + pmid:24590577 - p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") + a(MESH:"WAY 132983") increases path(MESH:Hypothermia) - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + + + + - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) regulates a(GO:aggresome) + a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) association a(GO:"Lewy body") + a(HBP:VU0184670) increases act(p(HGNC:CHRM1)) - pmid:18930136 + pmid:24590577 - p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") + a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") - pmid:18930136 + pmid:26088141 - p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) + p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) + + + + + + + + + + + + - pmid:18930136 + pmid:26088141 - p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(Ub))) + p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) + + + + - pmid:18930136 + pmid:26088141 - p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") + p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + + + + + + + + + + - pmid:30116051 + pmid:26088141 - p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") + composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) - pmid:30116051 + pmid:21958873 - p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HBP:"alpha-Bungarotoxin") causesNoChange a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:21958873 - bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + p(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"Receptors, Nicotinic")) + + + + - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) association path(MESH:"Alzheimer Disease") + p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) association path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) - pmid:18930136 + pmid:26088141 - bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(HBP:misfolding))) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") - pmid:29626319 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) association a(HBP:"Tau aggregates") + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:SNCA)) + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") - pmid:18930136 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:SNCA)) + g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) + + + + + + + + + + + + + + + + + + + + - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) decreases a(CHEBI:lipid) + composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(a(CHEBI:lipid)) + composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + + + + - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) + composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) + composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) + a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") - pmid:29758300 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:30145931 + pmid:26088141 - bp(GO:autophagy) decreases p(HGNC:MAPT) + a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") - pmid:24027553 + pmid:26088141 - bp(GO:autophagy) association deg(p(HGNC:MAPT)) + a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") - pmid:23528736 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:25374103 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) - pmid:29626319 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) - pmid:29626319 + pmid:26088141 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(GO:organelle)) + a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(GO:organelle)) + a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) increases deg(a(GO:organelle)) + a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) - pmid:18930136 + pmid:26088141 - bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) - pmid:18930136 + pmid:26088141 - bp(GO:autophagy) increases deg(a(GO:organelle)) + a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) - pmid:18930136 + pmid:26088141 - bp(GO:autophagy) increases deg(a(GO:organelle)) + a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") - pmid:22908190 + pmid:26088141 - bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") + a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + - pmid:22908190 + pmid:25514383 - bp(GO:autophagy) increases deg(p(HBP:"protein aggregates", pmod(Ub))) + a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:26195256 - bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) + a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:24762290 - bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") - pmid:22908190 + pmid:25514383 - bp(GO:autophagy) decreases path(MESH:Tauopathies) + a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:25514383 - bp(GO:autophagy) decreases path(HBP:neurotoxicity) + a(HP:"cholinergic neuron") association bp(GO:cognition) - pmid:22908190 + pmid:25514383 - bp(GO:autophagy) increases path(HBP:neurotoxicity) + a(HP:"cholinergic neuron") increases bp(GO:cognition) - pmid:30145931 + pmid:25514383 - bp(GO:autophagy) decreases path(HBP:neurotoxicity) + a(HP:"cholinergic neuron") association path(MESH:Attention) + + + + + + + + + + + + + + + + + + + + + + + + - pmid:22908190 + pmid:25514383 - bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") - pmid:23746257 + pmid:25514383 - bp(GO:autophagy) increases bp(GO:"protein catabolic process") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") - pmid:23746257 + pmid:28445721 - bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") - pmid:18930136 + pmid:21482353 - bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases deg(a(MESH:Proteins)) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) regulates bp(GO:"metabolic process") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) association bp(GO:"antigen processing and presentation") + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) decreases bp(MESH:Microbiota) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) regulates bp(GO:"cell death") + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"intracellular signal transduction") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases a(HBP:"alpha-synuclein aggregates") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph)) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases a(HBP:"alpha-synuclein oligomers") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) decreases path(HBP:Neurodegeneration) + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) decreases path(HBP:Neurodegeneration) + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) increases deg(p(HGNC:APP)) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) - pmid:26195256 + pmid:25514383 - bp(GO:autophagy) decreases p(HGNC:APP) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") - pmid:18930136 + pmid:25514383 - bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) - pmid:28803412 + pmid:25514383 - bp(GO:autophagy) increases a(HBP:HBP00093) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) - pmid:30145931 + pmid:25514383 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262))) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") - pmid:30145931 + pmid:28445721 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356))) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") - pmid:30116051 + pmid:28445721 - bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) - pmid:30116051 + pmid:21482353 - bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) - pmid:24027553 + pmid:21482353 - bp(GO:autophagy) association p(HGNC:NPEPPS) + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") - pmid:23702978 + pmid:21482353 - bp(GO:autophagy) regulates bp(GO:"apoptotic process") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") - pmid:23702978 + pmid:21482353 - bp(GO:autophagy) regulates complex(GO:"inflammasome complex") + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") - pmid:23702978 + pmid:21482353 - bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") - pmid:23702978 + pmid:21482353 - bp(GO:autophagy) decreases sec(p(HGNC:IL1B)) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") - pmid:22020111 + pmid:21482353 - p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) - pmid:27491084 + pmid:28132910 - p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973") - pmid:24563850 + pmid:30664622 - p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") + a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) - pmid:24563850 + pmid:30664622 - p(HGNC:HSPB8) association p(HGNC:EIF2A) + a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) - - - - - pmid:22020111 + pmid:25514383 - complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) + a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta")) - + + + + + - pmid:22020111 + pmid:25514383 - complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates")) + complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) - pmid:23746257 + pmid:25514383 - p(HGNC:BAG3) increases bp(GO:macroautophagy) + complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates") - pmid:25036637 + pmid:25514383 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:25036637 + pmid:25514383 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") - pmid:25036637 + pmid:25514383 - p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") - pmid:25036637 + pmid:25514383 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) + complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") - pmid:25036637 + pmid:27522251 - p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) + complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") + + + + + + + + - pmid:29626319 + pmid:25514383 - p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR")) - pmid:22020111 + pmid:25514383 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + - pmid:22020111 + pmid:25514383 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") + composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) - pmid:22020111 + pmid:28420982 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) - pmid:29758300 + pmid:25514383 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") + a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") - pmid:14556719 + pmid:28901280 - a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) - pmid:22020111 + pmid:30126037 - p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) + bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") - pmid:22020111 + pmid:24563850 - p(HGNC:TNFSF9) increases bp(GO:"T cell activation") + bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") - pmid:22020111 + pmid:30126037 - act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") + bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) - pmid:22020111 + pmid:28420982 - path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1) + bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT)) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:DHFR) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") - pmid:22020111 + pmid:28901280 - path(MESH:Atherosclerosis) increases p(HGNC:EDN1) + path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:ITGB3) + a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:MKI67) + a(CHEBI:"(-)-cotinine") increases bp(GO:memory) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:MMP11) + a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:MMP14) + a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:MMP2) + a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:PDE7A) + a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta") - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:PDE7B) + a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:PLAU) + a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) increases p(HGNC:PTGS1) + a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") - pmid:22020111 + pmid:25514383 - path(MESH:Atherosclerosis) increases p(HGNC:SCARB1) + a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) increases p(HGNC:TUBB3) + a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1) + a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) decreases p(HGNC:PPARA) + a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) increases p(HGNC:EGR1) + a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) increases p(HGNC:PTGS2) + a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") - pmid:22020111 + pmid:17640819 - path(MESH:Atherosclerosis) increases p(HGNC:SOAT1) + a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") - pmid:27594586 + pmid:17640819 - act(p(HGNC:MMP2)) increases bp(GO:"neuron death") + a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") - pmid:27594586 + pmid:25514383 - p(HGNC:MMP2) increases bp(GO:"neuron death") + a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") - pmid:29626319 + pmid:25514383 - act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY) + a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1) + a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27) + a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2) + a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A) + a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR) + a(CHEBI:simvastatin) increases bp(GO:cognition) - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11) + a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") - pmid:22020111 + pmid:29626319 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1) + a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta")) - pmid:22020111 + pmid:29626319 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2) + a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:22020111 + pmid:29626319 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10) + a(CHEBI:simvastatin) increases sec(p(HGNC:MME)) - pmid:22020111 + pmid:21718217 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) + bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) + + + + - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A) + composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) - pmid:22020111 + pmid:25881725 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2) + p(MGI:App, frag("25_35")) decreases bp(GO:learning) - pmid:22020111 + pmid:25881725 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25) + p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") - pmid:22020111 + pmid:25881725 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC) + p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region")) - pmid:22020111 + pmid:25881725 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1) + p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) + + + + + + - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97) + complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") + + + + - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13) + complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB) + a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3) + a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) - pmid:22020111 + pmid:25514383 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS) + a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta")) - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1) + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) - pmid:22020111 + pmid:27522251 - path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) - pmid:25036637 + pmid:27522251 - p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + + + + - pmid:25036637 + pmid:27522251 - p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") - pmid:14556719 + pmid:27522251 - act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") - pmid:18930136 + pmid:27522251 - p(HGNC:UBA1) increases bp(GO:autophagy) + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) + + + + - pmid:18930136 + pmid:27522251 - p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") + complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") + + + + - pmid:29626319 + pmid:27522251 - p(HGNC:UBA1) increases deg(a(MESH:Proteins)) + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") - pmid:25673844 + pmid:27522251 - p(HGNC:VRK1) isA p(HBP:"CK1 superfamily") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") - pmid:22020111 + pmid:27522251 - p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") - pmid:22020111 + pmid:27522251 - p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022) - pmid:22020111 + pmid:24762290 - p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) - pmid:24653673 + pmid:24762290 - p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) - pmid:24653673 + pmid:24762290 - p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons) - pmid:24653673 + pmid:24762290 - p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) - pmid:24653673 + pmid:24762290 - p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") - pmid:24653673 + pmid:24762290 - p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") - pmid:30116051 + pmid:24762290 - p(HGNC:CAPN1) decreases bp(GO:autophagy) + complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") - pmid:30116051 + pmid:24762290 - p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) + complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") - pmid:10391244 + pmid:24762290 - act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory) - pmid:10391244 + pmid:24762290 - p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") + a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:8282104 + pmid:24762290 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:8282104 + pmid:24762290 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(HBP:HBP00089) association bp(GO:"microglial cell activation") - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + a(HBP:HBP00089) increases sec(p(HGNC:TNF)) - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) - pmid:22072628 + pmid:21718217 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + a(HBP:HBP00089) increases sec(p(HGNC:IL6)) - pmid:8282104 + pmid:21718217 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) - pmid:8282104 + pmid:22807490 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:IFNG) increases p(HGNC:NOS2) - pmid:8282104 + pmid:23702978 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:IFNG) increases act(p(HGNC:NOS2)) - pmid:8282104 + pmid:22807490 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:IFNG) increases p(HGNC:PTGS2) - pmid:22072628 + pmid:23702978 - p(HGNC:CDK2) increases a(HBP:"Tau epitope, AT180") + p(HGNC:IFNG) increases p(HGNC:AIM2) - pmid:22072628 + pmid:23702978 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) - pmid:22072628 + pmid:23702978 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) + p(HGNC:IFNG) increases p(HGNC:CARD17) - pmid:30126037 + pmid:21718217 - p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") + act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") - pmid:30126037 + pmid:21718217 - p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") + act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:30126037 + pmid:21718217 - p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") - pmid:30126037 + pmid:21718217 - p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) + act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") - pmid:30126037 + pmid:21718217 - p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") + p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") - pmid:29758300 + pmid:21718217 - p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") - - - pmid:29758300 + pmid:21718217 - p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") + p(HGNC:PPARG) association bp(GO:"response to insulin") - pmid:29758300 + pmid:21718217 - p(HGNC:BECN1) association bp(GO:macroautophagy) + p(HGNC:PPARG) association bp(GO:"lipid storage") - pmid:29758300 + pmid:21718217 - p(HGNC:BECN1) association bp(GO:endocytosis) + p(HGNC:PPARG) increases p(HGNC:APOE) - pmid:29758300 + pmid:21718217 - p(HGNC:BECN1) increases bp(GO:phagocytosis) + p(HGNC:PPARG) increases p(HGNC:ABCA1) - - - pmid:30116051 + pmid:21718217 - act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") + p(HGNC:PPARG) increases p(HGNC:NR1H3) - pmid:27260836 + pmid:21718217 - p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) + act(p(HGNC:PPARG)) increases p(HGNC:ARG1) - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + act(p(HGNC:PPARG)) increases p(HGNC:IL4) - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:21718217 - p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) + act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24027553 + pmid:21718217 - p(HGNC:HTRA1) association bp(HBP:"APP processing") + act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) + act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules)) + act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils")) + p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") - pmid:24027553 + pmid:21718217 - act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates")) + p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") - pmid:22020111 + pmid:21718217 - p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:NR1H3) increases p(HGNC:APOE) - pmid:23702978 + pmid:21718217 - act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser)) + act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) - pmid:22020111 + pmid:21718217 - p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:NR1H3) increases p(HGNC:ABCA1) - - - pmid:14556719 + pmid:21718217 - p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") + act(p(HGNC:NR1H3)) increases bp(GO:memory) - + + + pmid:21718217 + + act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") + @@ -67093,1965 +67780,1862 @@

Statements

- pmid:24563850 + pmid:21718217 - p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") - - - pmid:22020111 + pmid:21718217 - bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") + p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") - pmid:22020111 + pmid:21718217 - bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:PPAR) association bp(GO:"fat cell differentiation") - pmid:26195256 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases path(MESH:Aging) + p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") - pmid:21131359 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + p(FPLX:PPAR) association bp(GO:"response to insulin") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) + p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") + p(FPLX:PPAR) association bp(GO:"response to tumor cell") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) + p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") + p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") + act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") - pmid:27623715 + pmid:21718217 - bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") + act(p(FPLX:RXR)) increases p(HGNC:APOE) - pmid:23722080 + pmid:21718217 - bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) + act(p(FPLX:RXR)) increases p(HGNC:ABCA1) + + + + - pmid:24355211 + pmid:21718217 - bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) + bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) - pmid:8226987 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) - pmid:7667312 + pmid:21718217 - bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments") + bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) - pmid:22020111 + pmid:21718217 - path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) + bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) - pmid:22020111 + pmid:25784053 - path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) + bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) - pmid:22020111 + pmid:21718217 - path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) + bp(GO:"fat cell differentiation") association p(FPLX:PPAR) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") + bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") + bp(GO:"response to insulin") association p(FPLX:PPAR) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") + bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) + bp(GO:"response to insulin") association p(HGNC:PPARG) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") + bp(GO:"response to tumor cell") association p(FPLX:PPAR) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") + bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) - - - - - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) + bp(GO:"lipid storage") association p(HGNC:PPARG) - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") + p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") - pmid:19277525 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") - pmid:19277525 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") - pmid:24653673 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:PPARD)) increases p(HGNC:ARG1) - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:PPARD)) increases p(HGNC:IL4) - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) - pmid:24653673 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) + a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) - pmid:24653673 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) + a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) - pmid:24653673 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) + bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) - pmid:24653673 + pmid:21718217 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) + a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) + a(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:HBP00030) increases a(HBP:HBP00018) - pmid:24653673 + pmid:30116051 - complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:HBP00030) increases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24653673 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:HBP00030) increases p(HGNC:LGMN) - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) + p(HGNC:ABCA1) increases p(HGNC:APOE) - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) + p(HGNC:ABCA1) decreases a(HBP:HBP00018) - pmid:24653673 + pmid:21718217 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:26195256 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) + p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:24653673 + pmid:29626319 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:29626319 - act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") + p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:29626319 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) + p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:28019679 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) + p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") - pmid:24653673 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) + p(HGNC:IDE) increases deg(p(HGNC:IAPP)) - pmid:24653673 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) + p(HGNC:IDE) decreases a(HBP:HBP00016) - pmid:10464280 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HBP:"microtubule-binding region") + p(HGNC:IDE) decreases a(HBP:HBP00018) - pmid:10464280 + pmid:30116051 - act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + p(HGNC:IDE) decreases a(HBP:HBP00092) - pmid:28720530 + pmid:29626319 - complex(GO:"protein phosphatase type 2A complex") negativeCorrelation p(HBP:"APOE e4") + p(HGNC:IDE) negativeCorrelation bp(GO:aging) - pmid:19277525 + pmid:29626319 - p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") + p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") - pmid:19277525 + pmid:28019679 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + a(CHEBI:"GW 3965") increases p(HGNC:APOE) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) + a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) + a(CHEBI:"GW 3965") increases bp(GO:memory) - pmid:19277525 + pmid:21718217 - act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) + a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) - - - - - - - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA) increases complex(GO:"protein phosphatase type 2A complex") + a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta") - - - - - - - - - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Abca1) decreases a(HBP:HBP00038) - pmid:26631930 + pmid:21718217 - act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) - pmid:24653673 + pmid:21718217 - deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) + a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) - pmid:29191965 + pmid:21718217 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) - pmid:26631930 + pmid:21718217 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26631930 + pmid:21718217 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:pioglitazone) increases bp(GO:behavior) - pmid:29062069 + pmid:21718217 - act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:pioglitazone) increases p(MGI:Abca1) - - - pmid:29626319 + pmid:21718217 - p(HGNC:PPP2CA) increases bp(GO:autophagy) + a(CHEBI:pioglitazone) increases p(MGI:Apoe) - pmid:10464280 + pmid:21718217 - p(HGNC:PPP2CA) association complex(GO:microtubule) + a(CHEBI:pioglitazone) increases bp(GO:memory) - pmid:10464280 + pmid:21718217 - p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) + a(CHEBI:pioglitazone) increases bp(GO:cognition) - pmid:29228318 + pmid:29626319 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta") - pmid:19401603 + pmid:21718217 - act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1)) + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) - pmid:19401603 + pmid:21718217 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) - pmid:19401603 + pmid:29626319 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:rosiglitazone) increases bp(GO:behavior) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") + a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") + a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta") - pmid:19277525 + pmid:29626319 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta")) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases act(complex(GO:"protein phosphatase type 2A complex")) + a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) + a(CHEBI:rosiglitazone) increases p(MGI:Abca1) - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:rosiglitazone) increases bp(GO:memory) - - - - - - - pmid:19277525 + pmid:21718217 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:rosiglitazone) increases bp(GO:cognition) - pmid:24653673 + pmid:29626319 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) - pmid:24653673 + pmid:19732809 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation a(HBP:"O-GlcNAcylation") - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me)) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) - pmid:24653673 - - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - - - - - - - pmid:24653673 + pmid:22798221 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule) + act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) - - - pmid:24653673 - - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth") - - - - - pmid:24653673 - - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") - - - pmid:24653673 + pmid:21718217 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"GW 501516") increases p(HGNC:APOA1) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") + a(CHEBI:"GW 501516") decreases a(HBP:HBP00018) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"GW 501516") increases p(HGNC:MME) - pmid:19277525 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"GW 501516") increases p(HGNC:IDE) - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) - pmid:24653673 + pmid:21718217 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) + a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) - - - - - - - pmid:19277525 + pmid:21718217 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018) - pmid:19277525 + pmid:21718217 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) - pmid:19277525 + pmid:26400044 - p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") - - - - - - - pmid:19277525 + pmid:26400044 - p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"APP processing") - pmid:19277525 + pmid:26400044 - p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) - pmid:19277525 + pmid:26400044 - p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain") + a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) - - - - - - - pmid:19277525 + pmid:26400044 - p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + a(CHEBI:"all-trans-retinoic acid") decreases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) - pmid:19277525 + pmid:21718217 - p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) - - - - - - - pmid:19277525 + pmid:21718217 - p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + a(CHEBI:bexarotene) increases p(HGNC:APOE) - pmid:19277525 + pmid:21718217 - p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + a(CHEBI:bexarotene) increases p(HGNC:ABCA1) - - - - - - - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:bexarotene) decreases a(HBP:HBP00018) - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:bexarotene) increases bp(GO:behavior) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + a(CHEBI:Honokiol) increases p(HGNC:APOE) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + a(CHEBI:Honokiol) increases p(HGNC:ABCA1) - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19277525 + pmid:11230871 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(HGNC:PPP2CA)) + bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") - pmid:24653673 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") - pmid:23943618 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) + p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") - pmid:19277525 + pmid:21718217 - p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) + a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) - pmid:19277525 + pmid:19721446 - p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19277525 + pmid:29758300 - p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") - pmid:29228318 + pmid:29758300 - p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA)) + a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) - - - - - pmid:24653673 + pmid:22908190 - complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - - - pmid:19277525 + pmid:22908190 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) - pmid:19277525 + pmid:22908190 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + a(CHEBI:cholesterol) increases a(GO:endosome) - pmid:24653673 + pmid:21718217 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HBP:HBP00030) association path(MESH:"Alzheimer Disease") - pmid:24653673 + pmid:21718217 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:IL10) decreases a(MESH:Macrophages) - pmid:24653673 + pmid:21718217 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) - pmid:24653673 + pmid:28445721 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + path(MESH:Motivation) association p(FPLX:CHRN) - pmid:23943618 + pmid:28445721 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:29281045 + pmid:28445721 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:19277525 + pmid:28445721 - act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:19277525 + pmid:28445721 - p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:24653673 + pmid:28445721 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:24653673 + pmid:22040696 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:22040696 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:24653673 + pmid:22040696 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:28445721 - p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) + p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) - pmid:24653673 + pmid:28445721 - p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me)) + p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:19277525 + pmid:28445721 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:19277525 + pmid:22040696 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") - pmid:19277525 + pmid:22040696 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) - pmid:24653673 + pmid:22040696 - act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:19277525 + pmid:22040696 - act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) + p(HGNC:RIC3) increases p(HGNC:CHRNA9) - pmid:19277525 + pmid:22040696 - p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + p(HGNC:RIC3) increases p(HGNC:CHRNA7) - pmid:19277525 + pmid:22040696 - p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") - pmid:19277525 + pmid:22040696 - p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) + act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") - pmid:24653673 + pmid:28445721 - p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:24653673 + pmid:28445721 - p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) + act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:24653673 + pmid:28445721 - p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) + act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:19277525 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) regulates bp(GO:"cell cycle") + act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174)) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) association bp(GO:"one-carbon metabolic process") + act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174)) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation a(CHEBI:homocysteine) + act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) regulates bp(HBP:"APP processing") + act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2") - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) regulates bp(MESH:"Neuronal Outgrowth") + act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4")) - pmid:24653673 + pmid:28445721 - p(FPLX:PPP2, pmod(Me)) regulates p(HGNC:MAPT) + act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4")) - - - - - - - pmid:23943618 + pmid:28445721 - act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) + act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4") - pmid:27068745 + pmid:28445721 - act(p(FPLX:PPP2), ma(kin)) positiveCorrelation p(HGNC:UNC5B) + act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:27068745 + pmid:28445721 - act(p(FPLX:PPP2), ma(kin)) increases act(p(HGNC:DAPK1)) + act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) - pmid:19277525 + pmid:28445721 - p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) + act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) - - - - - pmid:19277525 + pmid:28445721 - p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") + act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) - pmid:19277525 + pmid:28445721 - p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) + p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) - - - - - - - - - - - pmid:19277525 + pmid:28445721 - p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) - pmid:19277525 + pmid:28445721 - p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") - pmid:19277525 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Tmem35a) association p(MGI:Canx) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) - pmid:19277525 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) + p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) - pmid:19277525 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) + p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) + p(MGI:Tmem35a) increases a(HBP:HBP00180) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) + p(MGI:Tmem35a) increases complex(a(GO:membrane), a(MESH:Bungarotoxins)) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases bp(GO:cognition) + p(MGI:Tmem35a) increases p(FPLX:CHRN) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Tmem35a) regulates p(FPLX:CHRN) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis) + p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") decreases a(GO:synapse) + p(MGI:Tmem35a) decreases bp(GO:locomotion) - pmid:24653673 + pmid:28445721 - a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration) + p(MGI:Tmem35a) decreases bp(GO:locomotion) - pmid:16464864 + pmid:28445721 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") - pmid:16464864 + pmid:28445721 - a(CHEBI:"okadaic acid") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(MGI:Tmem35a) increases bp(GO:learning) - pmid:19277525 + pmid:28445721 - a(CHEBI:"microcystin-LR") decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Tmem35a) increases bp(GO:memory) - pmid:19277525 + pmid:28445721 - a(CHEBI:"microcystin-LR") decreases act(p(HGNC:PPME1)) + p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") - pmid:29228318 + pmid:28445721 - a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me)) + p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") @@ -69066,33 +69650,22 @@

Statements

- pmid:19277525 + pmid:11230871 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") + complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) - - - - - pmid:19277525 + pmid:11230871 - p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") + complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) - - - pmid:19277525 - - p(INTERPRO:"EF-hand domain") association p(HGNC:PPP2R3A) - - @@ -69109,6 +69682,13 @@

Statements

+ + + pmid:28445721 + + p(MGI:Canx) association p(MGI:Tmem35a) + + @@ -69117,27 +69697,37 @@

Statements

- pmid:19277525 + pmid:18174175 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(Ph)) + complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) - pmid:19277525 + pmid:21787755 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) - + + + pmid:28445721 + + a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + - + + + pmid:21787755 + + a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + @@ -69149,20 +69739,15 @@

Statements

- - - pmid:19277525 - - p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - + - pmid:19277525 + pmid:28445721 - p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) @@ -69173,139 +69758,137 @@

Statements

- pmid:19277525 + pmid:21482353 - complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:19277525 + pmid:27671637 - complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") + a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - - - - - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:19277525 + pmid:21482353 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) - pmid:19277525 + pmid:21482353 - p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") - pmid:24653673 + pmid:21482353 - p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") - pmid:19277525 + pmid:21482353 - p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") - pmid:19277525 + pmid:21482353 - p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) + + - pmid:24653673 + pmid:21482353 - p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:21482353 - p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) @@ -69318,36 +69901,38 @@

Statements

- pmid:19277525 + pmid:21482353 - composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + + - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) @@ -69358,1509 +69943,1521 @@

Statements

- pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) + complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) + + - pmid:24653673 + pmid:19721446 - deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) + p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) + + - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(Ph)) + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) - - - pmid:24653673 + pmid:21482353 - a(CHEBI:"S-adenosyl-L-methionine") increases act(p(HGNC:LCMT1)) + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) - pmid:24653673 + pmid:21482353 - a(CHEBI:"S-adenosyl-L-homocysteine") decreases act(p(HGNC:LCMT1)) + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN)) - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) - - - + + + pmid:21482353 + + p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me)) + p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") - pmid:24653673 + pmid:28901280 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:24653673 + pmid:28901280 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:Tauopathies) + p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) + + + + + + + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR")) + + + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) + + + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule) + complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR")) + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth") + a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") - pmid:24653673 + pmid:21482353 - p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") - pmid:24653673 + pmid:11230871 - p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging) - pmid:24653673 + pmid:11230871 - p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pmid:11230871 - p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) - pmid:24653673 + pmid:11230871 - p(HGNC:PPP2CA, pmod(Ub)) increases deg(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2CA, pmod(HBP:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R5A, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") - - - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R5D, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") - - - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(Ph)) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) + a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) - pmid:24653673 + pmid:21787755 - p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") - - - + + + pmid:21482353 + + p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") + - + + + pmid:21482353 + + p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") + - pmid:24653673 + pmid:21482353 - complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Lynx1) decreases bp(GO:learning) - + + + pmid:21482353 + + p(MGI:Lynx1) decreases bp(GO:memory) + - pmid:24653673 + pmid:21482353 - complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") - pmid:24653673 + pmid:21482353 - a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:24653673 + pmid:21482353 - a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) + p(MGI:Lynx1) increases a(MESH:Neurons) - pmid:24653673 + pmid:21482353 - a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) + act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) - + + + pmid:22299660 + + a(MESH:Brain) association p(HGNC:PPP2R2A) + - pmid:24653673 + pmid:24027553 - complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:Brain) association act(p(HGNC:NPEPPS)) - + + + pmid:21482353 + + p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) + - pmid:24653673 + pmid:21482353 - complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) - pmid:24653673 + pmid:21482353 - a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:PSCA) decreases bp(GO:"programmed cell death") - pmid:24653673 + pmid:21482353 - a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) + bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) - pmid:24653673 + pmid:21482353 - a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) + bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) - + + + pmid:21482353 + + bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + - pmid:24653673 + pmid:21482353 - complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) - + + + pmid:21482353 + + bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) + - pmid:24653673 + pmid:21482353 - complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") - pmid:24653673 + pmid:21482353 - p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") - pmid:24653673 + pmid:21482353 - p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) - pmid:24653673 + pmid:21482353 - p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:24653673 + pmid:21482353 - p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) + act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) - pmid:24653673 + pmid:24563850 - p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) + act(p(FPLX:NOS)) increases a(CHEBI:radical) - pmid:24653673 + pmid:24563850 - p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") - - - + + + pmid:24563850 + + act(p(FPLX:NOS)) increases a(CHEBI:"reactive nitrogen species") + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) - + + + pmid:21482353 + + g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - + + + pmid:21482353 + + a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"GTS-21") increases path(MESH:Attention) - pmid:24653673 + pmid:21482353 - a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"GTS-21") increases bp(GO:"sensory processing") - pmid:24653673 + pmid:21482353 - a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) + a(HBP:"GTS-21") decreases path(MESH:Anhedonia) - pmid:29758300 + pmid:21482353 - a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"GTS-21") decreases path(MESH:Aphasia) - pmid:24653673 + pmid:21482353 - a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:SLC12A5) decreases a(CHEBI:chloride) - pmid:21882945 + pmid:21482353 - a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) + + + pmid:21482353 + + p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) + + - pmid:24653673 + pmid:21482353 - complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR") - - - - - - - - - pmid:24653673 + pmid:21482353 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR") - pmid:24653673 + pmid:21482353 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) - pmid:24653673 + pmid:23746257 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") - - - - - - - - - pmid:24653673 + pmid:25784053 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:Fear) increases a(CHEBI:dopamine) - pmid:24653673 + pmid:21482353 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) - - - - - - - - - - - - - - - - - pmid:24653673 + pmid:21482353 - p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) - - - - - pmid:14556719 + pmid:21482353 - a(GO:microtubule) association p(HGNC:MAPT) + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:26631930 + pmid:21482353 - a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:18930136 + pmid:21482353 - a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:8282104 + pmid:21482353 - a(GO:microtubule) association p(HGNC:CDK5) + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:8282104 + pmid:21482353 - a(GO:microtubule) association p(HGNC:PRKACA) + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:8282104 + pmid:21482353 - a(GO:microtubule) association p(FPLX:ERK) + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:8282104 + pmid:21482353 - a(GO:microtubule) association p(FPLX:GSK3) + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:23487739 + pmid:21482353 - a(GO:microtubule) negativeCorrelation act(p(HGNC:HDAC6)) + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) - - - - - pmid:24653673 + pmid:21482353 - g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:24653673 + pmid:21482353 - r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:24653673 + pmid:19721446 - g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) - pmid:24653673 + pmid:19721446 - r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) - pmid:24653673 + pmid:19721446 - r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) - pmid:24653673 + pmid:28901280 - r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) - pmid:24653673 + pmid:28901280 - path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) - pmid:29758300 + pmid:28901280 - path(MESH:Tauopathies) association p(HGNC:MAPT) + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) - pmid:29758300 + pmid:28901280 - path(MESH:Tauopathies) association path(MESH:Dementia) + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) - pmid:29758300 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:30145931 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) - pmid:29024336 + pmid:21482353 - path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") - pmid:24027553 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") - pmid:27574109 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") - pmid:29686391 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) - pmid:27574109 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:21734277 + pmid:21482353 - path(MESH:Tauopathies) association p(HBP:"AT8 tau", pmod(Ph)) + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) - pmid:30108137 + pmid:21482353 - path(MESH:Tauopathies) increases p(MGI:Tfeb) + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") - pmid:30108137 + pmid:21482353 - path(MESH:Tauopathies) increases p(MGI:Tfeb) + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") - pmid:30108137 + pmid:21482353 - path(MESH:Tauopathies) increases p(MGI:Lamp1) + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") - pmid:30108137 + pmid:21482353 - path(MESH:Tauopathies) increases p(MGI:Ctsd) + p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) - pmid:21882945 + pmid:21482353 - path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") + path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") - pmid:28420982 + pmid:18986241 - path(MESH:Tauopathies) association bp(GO:"neuron death") + path(MESH:D019636) association path(MESH:D000544) - pmid:21882945 + pmid:18986241 - path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) + path(MESH:D001526) association path(MESH:D000544) - pmid:30126037 + pmid:18986241 - path(MESH:Tauopathies) association bp(GO:"cellular senescence") + path(HBP:aMCI) association path(MESH:D008569) - pmid:30126037 + pmid:18986241 - path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") + path(HBP:aMCI) association path(MESH:D003704) - pmid:22419736 + pmid:18986241 - path(MESH:Tauopathies) association a(CHEBI:"amyloid-beta polypeptide 42") + path(HBP:aMCI) association path(MESH:D000544) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:WNT2) + path(MESH:D008569) association path(HBP:aMCI) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:TTBK2) + path(HBP:mdMCI) association path(MESH:D060825) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:GSK3B) + path(MESH:D060825) association path(HBP:mdMCI) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:TAOK1) + path(MESH:D060825) association path(MESH:D062706) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:CTSE) + path(MESH:D060825) association bp(HBP:Neurodegeneration) - pmid:29191965 + pmid:18986241 - path(MESH:Tauopathies) association p(HGNC:CHRNA7) + path(MESH:D060825) causesNoChange act(p(HGNC:CHAT)) - pmid:25374103 + pmid:18986241 - path(MESH:Tauopathies) positiveCorrelation p(FPLX:Caspase) + path(MESH:D060825) increases act(p(HGNC:CHAT)) - pmid:28420982 + pmid:18986241 - path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils") + path(MESH:D060825) increases act(p(HGNC:CHAT)) - pmid:26631930 + pmid:18986241 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + path(MESH:D060825) decreases a(MESH:D013569) - pmid:26631930 + pmid:18986241 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(MESH:D060825) increases act(p(HGNC:MMP9)) - pmid:26631930 + pmid:18986241 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + path(MESH:D060825) causesNoChange r(HGNC:CHAT) - pmid:26631930 + pmid:18986241 - path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) + path(MESH:D060825) association p(HGNC:CHRM1) - pmid:24653673 + pmid:18986241 - p(FPLX:PPP2, pmod(Me, Tyr, 307)) association a(GO:"neurofibrillary tangle") + path(MESH:D060825) decreases a(HBP:"3R tau") - pmid:24653673 + pmid:18986241 - p(FPLX:PPP2, pmod(Me, Tyr, 307)) association p(HGNC:MAPT, pmod(Ph)) + path(MESH:D062706) association path(MESH:D060825) - pmid:24653673 + pmid:18986241 - p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") - pmid:24653673 + pmid:18986241 - p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") + a(MESH:D059329) association path(MESH:D008568) - pmid:24653673 + pmid:18986241 - p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:D059329) association path(MESH:D001288) - pmid:24653673 + pmid:18986241 - p(FPLX:PPP2, pmod(Ph, Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:D059329) association a(MESH:D016874) - pmid:24653673 + pmid:18986241 - p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:D059329) association path(MESH:D000544) - pmid:24653673 + pmid:18986241 - p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) + a(MESH:D059329) association a(MESH:D009479) - pmid:22908190 + pmid:18986241 - p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) + a(MESH:D059329) association a(MESH:D059330) - pmid:29626319 + pmid:18986241 - p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) + a(MESH:D059329) association p(RGD:Gal) - pmid:29626319 + pmid:18986241 - p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) + a(MESH:D059329) association path(MESH:D008570) - pmid:24653673 + pmid:18986241 - p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") + a(MESH:D059329) association path(MESH:D003704) - pmid:24653673 + pmid:18986241 - p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) + bp(GO:"GO:0060384") association p(HGNC:NGF) - pmid:24653673 + pmid:18986241 - p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) + path(MESH:D001288) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:D016874) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:D016874) association path(MESH:D000544) - pmid:24653673 + pmid:18986241 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) + a(MESH:D016874) association p(HGNC:BCHE) - pmid:24653673 + pmid:18986241 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) + a(MESH:D009479) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) + a(MESH:D059330) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) + p(RGD:Gal) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) + path(MESH:D008570) association a(MESH:D059329) - pmid:24653673 + pmid:18986241 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) + a(MESH:D005625) positiveCorrelation path(MESH:D011597) - pmid:24653673 + pmid:18986241 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) + path(MESH:D011597) positiveCorrelation a(MESH:D005625) - pmid:24653673 + pmid:18986241 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) + p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) + + + + - pmid:24653673 + pmid:18986241 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) + complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180") - - - - - pmid:25374103 + pmid:18986241 - complex(a(GO:microtubule), p(HGNC:MAPT)) decreases p(HGNC:MAPT, pmod(HBP:misfolded)) + complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") - pmid:26631930 + pmid:18986241 - complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") + p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072) - pmid:26631930 + pmid:18986241 - complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") + p(HGNC:NTRK1) biomarkerFor path(MESH:D000544) - pmid:26631930 + pmid:18986241 - complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(HBP:"Tau aggregates") + p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) + + - pmid:26631930 + pmid:18986241 - complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") + bp(GO:"GO:0038180") increases bp(GO:"GO:1990089") @@ -70871,612 +71468,645 @@

Statements

- pmid:24653673 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) - pmid:24653673 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"GO:1901214") association p(HGNC:NGFR) - pmid:17403556 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1) - pmid:22253473 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9)) - pmid:24653673 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))) + bp(MESH:D000375) increases p(HGNC:NGFR) - pmid:24653673 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))) + p(HGNC:SORT1) association path(MESH:D000544) - pmid:10391244 + pmid:18986241 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39")) + act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072) - pmid:10391244 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT)) + p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) - pmid:21367866 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37) + act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") - pmid:17078951 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA) + act(p(HGNC:MMP9)) increases bp(GO:"neuron death") - pmid:23948915 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") + p(HGNC:MMP9) increases bp(GO:"neuron death") - pmid:26118667 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation m(MIRBASE:"rno-mir-195") + act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) - pmid:22833681 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo a(HBP:"Tau epitope, AT180") + sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) - pmid:19623258 + pmid:29626319 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180") + act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:22926167 + pmid:29626319 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates") + p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta")) - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(Me)) + g(HGNC:NTRK1) association path(MESH:D003071) - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:NTRK2) association path(MESH:D003071) - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis) + g(HGNC:NTRK3) association path(MESH:D003071) - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668)) + bp(GO:"GO:0000165") association bp(GO:"GO:0006915") - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") decreases bp(GO:cognition) + bp(GO:"GO:0000165") association bp(GO:"GO:0030182") - pmid:24653673 + pmid:18986241 - bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta")) + bp(GO:"GO:0000165") increases act(p(FPLX:RAS)) - pmid:24653673 + pmid:18986241 - a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(Me)) + bp(GO:"GO:0000165") increases act(p(FPLX:RAF)) - pmid:24653673 + pmid:18986241 - a(CHEBI:folates) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"GO:0000165") increases act(p(FPLX:MEK)) - pmid:24653673 + pmid:18986241 - a(CHEBI:folates) increases p(HGNC:APP, pmod(Ph)) + bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK)) - pmid:24653673 + pmid:18986241 - path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me)) + bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2)) - pmid:24653673 + pmid:18986241 - path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"GO:0006915") association bp(GO:"GO:0000165") - pmid:24653673 + pmid:18986241 - path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph)) + bp(GO:"GO:0030182") association bp(GO:"GO:0000165") - pmid:24653673 + pmid:18986241 - a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(Me)) + act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph)) - pmid:24653673 + pmid:18986241 - a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph)) + + - pmid:24653673 + pmid:18986241 - a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(Ph)) + bp(GO:"GO:0014065") regulates bp(MESH:D002470) - pmid:28632203 + pmid:18986241 - a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") + bp(GO:"GO:0014065") association p(FPLX:RAS) - pmid:25437566 + pmid:18986241 - act(p(FPLX:HSP90)) association a(CHEBI:ATP) + bp(GO:"GO:0014065") association p(HGNC:IRS1) - pmid:25437566 + pmid:18986241 - p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:"GO:0014065") association p(HGNC:GAB1) - pmid:25437566 + pmid:18986241 - p(FPLX:HSP90) increases bp(GO:"protein folding") + bp(GO:"GO:0043491") regulates bp(MESH:D002470) - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSP90)) increases bp(GO:"protein folding") + bp(GO:"GO:0043491") association p(FPLX:RAS) - pmid:25784053 + pmid:18986241 - p(FPLX:HSP90) regulates bp(GO:"protein folding") + bp(GO:"GO:0043491") association p(HGNC:IRS1) - pmid:29311797 + pmid:18986241 - act(p(FPLX:HSP90)) increases bp(GO:"protein folding") + bp(GO:"GO:0043491") association p(HGNC:GAB1) - pmid:27491084 + pmid:18986241 - p(FPLX:HSP90) association bp(HBP:Proteostasis) + p(HGNC:IRS1) association bp(GO:"GO:0014065") - pmid:29311797 + pmid:18986241 - p(FPLX:HSP90) association bp(HBP:Proteostasis) + p(HGNC:IRS1) association bp(GO:"GO:0043491") - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") + p(HGNC:GAB1) association bp(GO:"GO:0014065") - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSP90)) association bp(GO:"protein refolding") + p(HGNC:GAB1) association bp(GO:"GO:0043491") - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(GO:"cell cycle") + act(p(HGNC:PLCG1)) association bp(MESH:D018384) + + - pmid:23746257 + pmid:18467332 - p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") + p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") + bp(MESH:D018384) association act(p(HGNC:PLCG1)) - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(GO:"protein transport") + bp(MESH:D018384) association path(MESH:D000375) - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(GO:"protein secretion") + bp(MESH:D018384) association path(MESH:D009410) - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(GO:"immune response") + path(MESH:D000375) association bp(MESH:D018384) - pmid:23746257 + pmid:18986241 - p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") + path(MESH:D009410) association bp(MESH:D018384) - pmid:25784053 + pmid:18986241 - p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") + bp(GO:"GO:0006665") association act(p(HGNC:NGFR)) - pmid:25784053 + pmid:18986241 - p(FPLX:HSP90) regulates bp(MESH:Proteolysis) + p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") - pmid:29311797 + pmid:18986241 - act(p(FPLX:HSP90)) increases bp(MESH:Proteolysis) + p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165") - - - pmid:25784053 - - act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) - + - pmid:24563850 + pmid:18986241 - p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") + path(MESH:D024801) association p(HGNC:CHRM1) - pmid:29311797 + pmid:18986241 - act(p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") + path(MESH:D000686) association p(HGNC:CHRM1) - pmid:29311797 + pmid:26751493 - p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") + r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") - pmid:21882945 + pmid:18986241 - act(p(FPLX:HSP90)) association a(CHEBI:celastrol) + bp(HBP:hyperphosphorylation) association path(MESH:D016874) + + - pmid:21882945 + pmid:17493042 - p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) - pmid:21882945 + pmid:23407988 - p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") + p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") - - - pmid:21882945 - - p(FPLX:HSP90) increases bp(GO:autophagy) - + + + - pmid:21882945 + pmid:17493042 - p(FPLX:HSP90) increases act(p(HGNC:STUB1)) + p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) - pmid:21882945 + pmid:23407988 - p(FPLX:HSP90) increases bp(GO:"protein catabolic process") + p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") - - - pmid:21882945 - - p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - + + + + + - pmid:21882945 + pmid:17493042 - p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) - pmid:21882945 + pmid:23407988 - p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau") + + + + + + + + + + - pmid:19363271 + pmid:17493042 - p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) - pmid:21882945 + pmid:23407988 - p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) + p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau") + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:21882945 + pmid:29191965 - p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) + p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") - pmid:29311797 + pmid:29191965 - p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) + p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") @@ -71485,16 +72115,16 @@

Statements

pmid:25374103 - p(FPLX:HSP90) regulates deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HBP:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") - pmid:29311797 + pmid:25374103 - p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HBP:"Tau isoform F (441 aa)") positiveCorrelation act(p(HGNC:CASP3)) @@ -71503,43 +72133,44 @@

Statements

pmid:25374103 - p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:29311797 + pmid:25374103 - act(p(FPLX:HSP90)) increases bp(GO:"protein modification process") + p(HBP:"Tau isoform F (441 aa)") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:29311797 + pmid:17493042 - p(FPLX:HSP90) regulates a(HBP:"Tau aggregates") + p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) - - - pmid:29311797 - - p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) - + + + + + + + - pmid:29311797 + pmid:23407988 - p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") + p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau") @@ -71554,1435 +72185,1460 @@

Statements

- pmid:29311797 + pmid:30145931 - act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) + r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:19363271 + pmid:27574109 - p(FPLX:HSP90) association p(HBP:"VQIVYK motif") + a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:19363271 + pmid:27574109 - p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:19363271 + pmid:27574109 - p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") - pmid:20133804 + pmid:27574109 - p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) + a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21367866 + pmid:27574109 - act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) + a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:21367866 + pmid:18986241 - act(p(FPLX:HSP90)) negativeCorrelation deg(p(HGNC:MAPT)) + act(p(HGNC:GAL)) association path(MESH:D003071) - pmid:25437566 + pmid:18986241 - act(p(FPLX:HSPA)) association a(CHEBI:ATP) + act(p(HGNC:GAL)) association bp(MESH:D009473) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) association bp(HBP:Proteostasis) + act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates") + act(p(HGNC:GAL)) regulates act(a(MESH:D059329)) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta") - pmid:24563850 + pmid:18986241 - p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + act(p(HGNC:GAL)) increases r(HGNC:CHAT) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") + act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423") - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) - pmid:24563850 + pmid:18986241 - p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") + bp(MESH:D009473) association act(p(HGNC:GAL)) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases bp(HBP:misfolding) + a(HBP:"Tau C3") biomarkerFor path(MESH:D059329) - pmid:24563850 + pmid:18986241 - p(FPLX:HSPA) decreases bp(HBP:misfolding) + p(RGD:Ngf) increases r(RGD:Gal) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + p(RGD:Ngf) decreases path(MESH:D060825) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + bp(GO:"GO:0050435") association a(MESH:D002800) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases path(HBP:proteotoxicity) + path(MESH:D007319) association a(MESH:D002800) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases path(HBP:proteotoxicity) + path(MESH:D003967) association a(MESH:D002800) - pmid:27491084 + pmid:18986241 - p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") + path(MESH:D009325) association a(MESH:D002800) - pmid:23746257 + pmid:18986241 - p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") + path(MESH:D005221) association a(MESH:D002800) - pmid:14556719 + pmid:18986241 - p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) + path(MESH:D000855) association a(MESH:D002800) - pmid:14556719 + pmid:18986241 - p(FPLX:HSPA) increases a(HBP:"protein aggregates") + bp(GO:"GO:0007269") association p(HGNC:NGF) - pmid:14556719 + pmid:18986241 - p(FPLX:HSPA) increases bp(GO:"cell death") + bp(GO:"GO:0048485") association p(HGNC:NGF) - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + path(MESH:D002100) association p(HGNC:NGF) - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + path(MESH:D006930) association p(HGNC:NGF) - pmid:23746257 + pmid:18986241 - act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") + g(HGNC:NGF) directlyIncreases p(HGNC:NGF) - pmid:23746257 + pmid:11230871 - act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") + a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) - pmid:23746257 + pmid:11230871 - p(FPLX:HSPA) decreases a(HBP:"huntingtin aggregates") + path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) + + + + + + + + + + + + + + + + - pmid:25784053 + pmid:11230871 - p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") + a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") - pmid:25784053 + pmid:11230871 - p(FPLX:HSPA) regulates bp(GO:"protein folding") + a(PUBCHEM:132228) increases p(FPLX:CHRN) - pmid:24563850 + pmid:11230871 - p(FPLX:HSPA) increases bp(GO:"protein folding") + a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) - pmid:25784053 + pmid:11230871 - p(FPLX:HSPA) regulates bp(MESH:Proteolysis) + a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") - pmid:25784053 + pmid:11230871 - p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") + a(PUBCHEM:119380) increases bp(GO:memory) - pmid:29626319 + pmid:28132910 - p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:25437566 + pmid:28132910 - act(p(HGNC:HSPD1)) association a(CHEBI:ATP) + a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:27491084 + pmid:28132910 - p(HGNC:HSPD1) association bp(HBP:Proteostasis) + a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:25784053 + pmid:28132910 - p(HGNC:HSPD1) increases bp(HBP:Proteostasis) + a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:23746257 + pmid:28132910 - p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") + a(HBP:"B-973") increases act(a(CHEBI:acetylcholine)) - pmid:25784053 + pmid:28132910 - p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") + a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) - pmid:25784053 + pmid:28132910 - p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") + a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) - pmid:27491084 + pmid:28132910 - p(HGNC:TPR) association bp(HBP:Proteostasis) + a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) + + + + + + + + + + + + - pmid:27491084 + pmid:28132910 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(HBP:Proteostasis) + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:27491084 + pmid:28391535 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:23746257 + pmid:28391535 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:23746257 + pmid:28391535 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"huntingtin aggregates") + a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) - pmid:23746257 + pmid:28391535 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) + + + + - pmid:25784053 + pmid:17640819 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta") + + - pmid:27491084 + pmid:25881725 - p(FPLX:HSPB) association bp(HBP:Proteostasis) + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) - pmid:27491084 + pmid:25881725 - p(FPLX:HSPB) association bp(HBP:misfolding) + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) - pmid:23746257 + pmid:25881725 - act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) - pmid:25784053 + pmid:25881725 - p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) - pmid:25437566 + pmid:25881725 - p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") - pmid:25437566 + pmid:25881725 - p(HGNC:HSPA8) increases bp(GO:"protein folding") + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") - pmid:25437566 + pmid:25881725 - p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates") + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) - pmid:29758300 + pmid:25881725 - p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) - pmid:21882945 + pmid:25881725 - act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT)) + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) - pmid:18930136 + pmid:19721446 - p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) + a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18930136 + pmid:19721446 - p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) + a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:24706768 + pmid:19721446 - p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) - pmid:24706768 + pmid:19721446 - p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) - pmid:24706768 + pmid:19721446 - p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") + p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) - pmid:21882945 + pmid:19721446 - p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) - pmid:18500754 + pmid:19721446 - p(HGNC:HSPA8) association p(HBP:"microtubule-binding region") + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) - pmid:18500754 + pmid:19721446 - act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) - pmid:25437566 + pmid:19721446 - p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) - pmid:25437566 + pmid:19721446 - p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates") + p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) - pmid:23746257 + pmid:19721446 - p(FPLX:"CCT_complex") decreases a(HBP:"huntingtin aggregates") + p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) - pmid:25784053 + pmid:19721446 - p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") + p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) - pmid:25784053 + pmid:19721446 - p(FPLX:"CCT_complex") association bp(GO:"cell division") + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) - pmid:25784053 + pmid:19721446 - p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) - pmid:25784053 + pmid:19721446 - p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) - pmid:25437566 + pmid:19721446 - p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) - pmid:25437566 + pmid:19721446 - p(HGNC:DNAJA1) increases bp(GO:"protein folding") + p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) - pmid:25437566 + pmid:19721446 - p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates") + p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) - pmid:25437566 + pmid:19721446 - p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) - pmid:23746257 + pmid:19721446 - p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) - pmid:25036637 + pmid:19721446 - p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + a(MESH:"AR-R 17779") increases bp(GO:learning) - pmid:29311797 + pmid:19721446 - p(HGNC:STIP1) decreases p(HGNC:MAPT) + a(MESH:"AR-R 17779") increases bp(GO:memory) - pmid:29311797 + pmid:19721446 - p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") + a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) - pmid:25784053 + pmid:19721446 - bp(GO:"protein folding") association bp(HBP:Proteostasis) + a(DRUGBANK:Facinicline) increases bp(GO:cognition) - pmid:29311797 + pmid:19721446 - bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") + a(DRUGBANK:Facinicline) increases bp(GO:memory) - pmid:25437566 + pmid:19721446 - p(HGNC:TTC1) increases bp(GO:"protein folding") + a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") - pmid:24706768 + pmid:19721446 - a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity) - pmid:24706768 + pmid:19721446 - a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + a(MESH:"Entorhinal Cortex") association bp(GO:memory) - pmid:25437566 + pmid:19721446 - p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates") + path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") - pmid:25437566 + pmid:19721446 - p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates") + path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) - pmid:25437566 + pmid:19721446 - p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates") + a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") - pmid:25437566 + pmid:19721446 - p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates") + bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:25437566 + pmid:19721446 - p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates") + bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) - pmid:25036637 + pmid:19721446 - p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) + a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") - pmid:29311797 + pmid:19721446 - p(HGNC:HSP90AB1) association bp(GO:"embryo development") + a(CHEBI:clozapine) association p(HGNC:CHRNA7) - pmid:29311797 + pmid:19721446 - p(HGNC:HSP90AB1) association bp(GO:"cell maturation") + a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) - pmid:29311797 + pmid:19721446 - p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") + a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") - pmid:29311797 + pmid:19721446 - p(HGNC:HSP90AB1) association bp(GO:"signal transduction") + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) - pmid:29311797 + pmid:28391535 - p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) - pmid:27491084 + pmid:28391535 - a(MESH:"Molecular Chaperones") decreases path(HBP:proteotoxicity) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) - pmid:23746257 + pmid:19721446 - a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") + a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:25784053 + pmid:28901280 - a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") + a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic") - pmid:21882945 + pmid:28901280 - a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine)) - pmid:29311797 + pmid:28391535 - a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") + a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:29311797 + pmid:28391535 - a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(HGNC:HSPD1) + a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), p(HGNC:CHRNB2)) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(FPLX:HSPA) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta2")) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(HGNC:TPR) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha4beta2")) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(FPLX:HSPB) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta4")) - pmid:27491084 + pmid:28391535 - bp(HBP:Proteostasis) association p(FPLX:HSP90) + a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:29311797 + pmid:19721446 - bp(HBP:Proteostasis) association p(FPLX:HSP90) + a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") - pmid:27491084 + pmid:19721446 - bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") + a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:23746257 + pmid:19721446 - bp(HBP:Proteostasis) association bp(GO:"inflammatory response") + a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) - pmid:23746257 + pmid:28391535 - bp(HBP:Proteostasis) association bp(GO:"response to oxidative stress") + a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2")) - pmid:23746257 + pmid:28391535 - bp(HBP:Proteostasis) association bp(GO:"behavioral response to starvation") + a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + + - pmid:23746257 + pmid:19721446 - bp(HBP:Proteostasis) negativeCorrelation bp(GO:"cell death") + complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + + + + + + - pmid:25784053 + pmid:19721446 - bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis") + complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + + + + - pmid:25784053 + pmid:19721446 - bp(HBP:Proteostasis) association bp(GO:"protein folding") + complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") - pmid:25784053 + pmid:19721446 - bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") + g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") - pmid:25784053 + pmid:19721446 - bp(HBP:Proteostasis) association bp(MESH:Proteolysis) + g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") - pmid:25784053 + pmid:19721446 - bp(HBP:Proteostasis) decreases bp(MESH:Aging) + g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") - pmid:21882945 + pmid:19721446 - bp(HBP:Proteostasis) regulates p(HGNC:MAPT) + path(MESH:Recurrence) association p(HGNC:CHRNA3) - pmid:21882945 + pmid:19721446 - bp(HBP:Proteostasis) regulates a(MESH:Proteins) + path(MESH:Recurrence) association p(HGNC:CHRNB4) - pmid:27491084 + pmid:19721446 - p(HGNCGENEFAMILY:"AAA ATPases") association bp(HBP:Proteostasis) + a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) - pmid:27491084 + pmid:19721446 - p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27491084 + pmid:19721446 - p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + a(CHEBI:sertraline) decreases a(CHEBI:monoamine) - pmid:27491084 + pmid:19721446 - path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) + a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27491084 + pmid:19721446 - path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) + a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) - pmid:27491084 + pmid:19721446 - path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) + a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27491084 + pmid:19721446 - p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) + a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) - pmid:23528736 + pmid:19721446 - p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") + a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - pmid:14556719 + pmid:19721446 - p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) + a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) - - - pmid:27491084 + pmid:19721446 - p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) + a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - pmid:30640040 + pmid:19721446 - p(HGNC:AR) association a(PUBCHEM:5833) + a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) - pmid:27491084 + pmid:19721446 - p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) + a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:29758300 + pmid:19721446 - p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") + a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) - pmid:14556719 + pmid:19721446 - p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") + a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:14556719 + pmid:19721446 - p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR")) - pmid:18930136 + pmid:19721446 - p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) - pmid:18930136 + pmid:19721446 - p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) - pmid:30116051 + pmid:19721446 - p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) - pmid:30116051 + pmid:19721446 - p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") + a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR")) - - - pmid:29758300 - - p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:29758300 + pmid:19721446 - p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) - pmid:29758300 + pmid:19721446 - p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) - pmid:28803412 + pmid:28901280 - p(HGNC:SNCA) association path(MESH:"Parkinson Disease") + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") - - - pmid:29758300 + pmid:28901280 - p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") + path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") - - - - - - - pmid:14556719 + pmid:22040696 - p(HGNC:SNCA) association p(HGNC:SNCAIP) + p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) - - - pmid:22908190 + pmid:22040696 - p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) + p(FPLX:"p14_3_3") increases p(FPLX:CHRN) - pmid:14556719 + pmid:22040696 - p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") + p(HGNC:HSPA5) increases p(FPLX:CHRN) - pmid:14556719 + pmid:22040696 - p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") + p(HGNC:CANX) increases p(FPLX:CHRN) - pmid:14556719 + pmid:22040696 - p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization") + complex(GO:"proteasome complex") regulates p(FPLX:CHRN) - pmid:14556719 + pmid:22040696 - p(HGNC:SNCA) increases bp(GO:"apoptotic process") + complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") - - - pmid:14556719 + pmid:22040696 - act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub)) + complex(GO:"proteasome complex") regulates p(HGNC:RIC3) - pmid:14556719 + pmid:29758300 - act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub)) + complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(Ph)) - pmid:14556719 + pmid:29758300 - act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") + complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) @@ -72991,34 +73647,34 @@

Statements

pmid:14556719 - p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) - pmid:22908190 + pmid:14556719 - p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) - pmid:25784053 + pmid:14556719 - p(HGNC:SNCA) decreases bp(GO:autophagy) + complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) - pmid:25784053 + pmid:14556719 - p(HGNC:SNCA) decreases p(HGNC:RAB1A) + complex(GO:"proteasome complex") increases a(CHEBI:peptide) @@ -73027,125 +73683,119 @@

Statements

- - - - - - - pmid:25784053 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis) + complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:25784053 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") + complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta")) - pmid:25784053 + pmid:22908190 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) + act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:"amyloid-beta") - pmid:25784053 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:25784053 + pmid:22908190 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:24706768 + pmid:22908190 - path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:24706768 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) - pmid:27574109 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") + act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) - pmid:27574109 + pmid:18930136 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) - pmid:27574109 + pmid:14556719 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") + act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) - pmid:27574109 + pmid:22908190 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(Ub))) - pmid:27574109 + pmid:22908190 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(UbK48))) - pmid:27491084 + pmid:22908190 - p(HGNC:STUB1) decreases path(HP:Neurodegeneration) + act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"paired helical filaments") @@ -73154,852 +73804,911 @@

Statements

pmid:22908190 - p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) + act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") - pmid:25036637 + pmid:22908190 - p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:25036637 + pmid:22908190 - p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(Ub))) - pmid:25036637 + pmid:22908190 - p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1)) + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) - pmid:25374103 + pmid:22908190 - p(HGNC:STUB1) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) - pmid:25036637 + pmid:22908190 - p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) - pmid:24027553 + pmid:30116051 - p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(Ub)) + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) - pmid:23528736 + pmid:26751493 - p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) - pmid:21882945 + pmid:17954934 - act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") + act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) - pmid:21882945 + pmid:24457024 - act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - pmid:25374103 + pmid:18930136 - p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + act(complex(GO:"proteasome complex")) decreases path(HBP:Neurodegeneration) - pmid:25374103 + pmid:18930136 - p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) + act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) - pmid:25374103 + pmid:17954934 - p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) + act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") - pmid:25374103 + pmid:17954934 - p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) - pmid:25374103 + pmid:19732809 - p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) + act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"O-GlcNAcylation") - pmid:25374103 + pmid:19732809 - p(HGNC:STUB1) negativeCorrelation p(HBP:"Tau C3") + act(complex(GO:"proteasome complex")) positiveCorrelation g(HGNC:OGT) - pmid:25374103 + pmid:26041011 - p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) + act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates") - pmid:25374103 + pmid:26692334 - p(HGNC:STUB1) causesNoChange bp(GO:"cell death") + act(complex(GO:"proteasome complex")) positiveCorrelation act(p(FPLX:PKA)) - - - pmid:25374103 - - p(HGNC:STUB1) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) - + + + + + + + + + + + + + + + + + + + - pmid:25374103 + pmid:22040696 - p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(Ub)), p(HGNC:STUB1)) + composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A)) + + + + + + - pmid:25374103 + pmid:22040696 - p(HGNC:STUB1) increases deg(p(HBP:"4R tau", var("p.Lys280del"))) + p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) - pmid:25374103 + pmid:22040696 - p(HGNC:STUB1) negativeCorrelation act(p(FPLX:Caspase)) + p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN)) + + + + - pmid:25374103 + pmid:22040696 - p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) + complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") + + + + - pmid:25374103 + pmid:22040696 - p(HGNC:STUB1) increases complex(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) + complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") + + + + - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) association path(MESH:"Huntington Disease") + complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) + + + + - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) association path(MESH:"Parkinson Disease") + complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7)) - pmid:29311797 + pmid:21787755 - p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") + bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) association path(MESH:Neoplasms) + act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(Ph))) + act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7)) - pmid:29311797 + pmid:22040696 - p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:misfolding))) + p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7)) - pmid:26631930 + pmid:22040696 - p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) + p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7)) - pmid:14612456 + pmid:22040696 - p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) + p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) - pmid:17954934 + pmid:22040696 - p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) + r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) - pmid:25031639 + pmid:22040696 - act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8") + r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") - pmid:25031639 + pmid:22040696 - act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) + path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) - pmid:27325702 + pmid:22040696 - p(HGNC:STUB1) association p(HBP:"APP, ACR") + path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) - pmid:27325702 + pmid:22040696 - p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") + bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") + + + + - pmid:27491084 + pmid:18174175 - p(UNIPROT:P15705) decreases path(HBP:proteotoxicity) + complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) + + + + - pmid:27491084 + pmid:26837465 - p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) + p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") - pmid:27491084 + pmid:26837465 - p(UNIPROT:P32589) decreases path(HBP:proteotoxicity) + p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") - pmid:27491084 + pmid:26837465 - p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + - pmid:27491084 + pmid:21787755 - p(HGNC:HSPB7) decreases path(HBP:proteotoxicity) + bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") + + + + - pmid:27491084 + pmid:21787755 - p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") + a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") - pmid:27491084 + pmid:21787755 - p(UNIPROT:Q9XXG5) decreases path(HBP:proteotoxicity) + a(HBP:AβOs) association path(MESH:"Alzheimer Disease") - pmid:27491084 + pmid:21787755 - p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") + a(HBP:AβOs) association path(MESH:Epilepsy) - pmid:27491084 + pmid:22908190 - p(UNIPROT:P12612) decreases path(HBP:proteotoxicity) + a(HBP:AβOs) decreases act(a(GO:synapse)) - pmid:27491084 + pmid:22908190 - p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") + a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation") - pmid:27491084 + pmid:22908190 - p(UNIPROT:P02829) decreases path(HBP:proteotoxicity) + a(HBP:AβOs) decreases bp(GO:learning) - pmid:27491084 + pmid:22908190 - p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") + a(HBP:AβOs) decreases bp(GO:memory) - pmid:23746257 + pmid:22908190 - bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) + a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") - pmid:23746257 + pmid:22908190 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + a(HBP:AβOs) decreases bp(GO:"L-glutamate import") - pmid:23746257 + pmid:22908190 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:23746257 + pmid:22908190 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) + a(HBP:AβOs) increases deg(a(MESH:Neurites)) - pmid:27491084 + pmid:22908190 - bp(HBP:misfolding) association p(FPLX:HSPB) + a(HBP:AβOs) decreases act(complex(GO:"proteasome complex")) - pmid:24563850 + pmid:28528849 - bp(HBP:misfolding) increases path(MESH:"Protein Aggregation, Pathological") + a(HBP:AβOs) decreases a(MESH:"Dendritic Spines") + + + + - pmid:29758300 + pmid:21787755 - a(HBP:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") + a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") + + + + - pmid:29758300 + pmid:21787755 - a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") + + + + - pmid:14556719 + pmid:21787755 - a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") + a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) - pmid:14556719 + pmid:21787755 - a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") + a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) - pmid:14556719 + pmid:21787755 - a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) - pmid:27491084 + pmid:21787755 - p(HGNC:HSPB1) association a(HBP:"amyloid-beta aggregates") + a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") + a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) increases bp(GO:autophagy) + path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + path(MESH:Reward) association r(HGNC:CHRNA6) - pmid:14963027 + pmid:21787755 - p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + path(MESH:Reward) association p(HGNC:CHRNA6) - pmid:21882945 + pmid:28901280 - p(HGNC:HSPB1) increases p(HGNC:MAPT) + path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) decreases p(HGNC:MAPT) + path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") - pmid:14963027 + pmid:21787755 - p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) + a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) + a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) - pmid:21882945 + pmid:21787755 - p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") + a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) - pmid:14963027 + pmid:21787755 - p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) + a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) - pmid:14963027 + pmid:21787755 - p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) + bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) - pmid:14963027 + pmid:21787755 - p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") + bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) + + + + - pmid:27491084 + pmid:28901280 - p(HGNC:CRYAB) association a(HBP:"amyloid-beta aggregates") + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) - pmid:27491084 + pmid:28901280 - p(HGNC:HSPB6) association a(HBP:"amyloid-beta aggregates") + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:27491084 + pmid:28901280 - p(HGNC:HSF1) increases bp(HBP:Proteostasis) + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:21882945 + pmid:28901280 - p(HGNC:HSF1) increases bp(HBP:Proteostasis) + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:23746257 + pmid:28901280 - p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") + a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") - pmid:23746257 + pmid:28901280 - p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") + a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation") - pmid:25784053 + pmid:28901280 - act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones") + a(MESH:Acetylcholine) association bp(GO:"cell adhesion") - pmid:23746257 + pmid:28901280 - p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") + a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") - pmid:25784053 + pmid:28901280 - act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + a(MESH:Acetylcholine) association bp(GO:"secretion by cell") - - - pmid:25784053 + pmid:28901280 - act(p(HGNC:HSF1)) association path(MESH:Neoplasms) + a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") - pmid:24563850 + pmid:28901280 - p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + a(MESH:Acetylcholine) association bp(MESH:Apoptosis) - pmid:21882945 + pmid:28901280 - p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") - - - pmid:30116051 + pmid:28901280 - act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA)) + a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") - pmid:27491084 + pmid:28901280 - a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) + a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling") - pmid:27491084 + pmid:28901280 - a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) + a(MESH:Acetylcholine) decreases path(MESH:Inflammation) - - - - - pmid:25784053 + pmid:28901280 - p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + a(MESH:Acetylcholine) increases path(MESH:Neoplasms) - pmid:22817713 + pmid:28901280 - p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates") + a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) - pmid:22817713 + pmid:28901280 - p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates")) + a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) @@ -74010,2519 +74719,2529 @@

Statements

- pmid:25784053 + pmid:28901280 - p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Nicotine) decreases a(MESH:Neurons) - pmid:25784053 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) + a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) + a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") + a(MESH:Nicotine) increases a(MESH:Glutamates) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Nicotine) increases a(MESH:Glutamates) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") + a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) + a(MESH:Nicotine) increases bp(GO:"action potential initiation") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) + a(MESH:Nicotine) increases a(MESH:Dopamine) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) association p(HGNC:BECN1) + a(MESH:Nicotine) increases a(MESH:Dopamine) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") + a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(HBP:"Tau aggregates")) + a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) + a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") + a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") + act(a(MESH:Nicotine)) association g(DNSNP:rs16969968) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(MESH:Nicotine) increases path(MESH:Neoplasms) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) - pmid:29758300 + pmid:28901280 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") + a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) + + + + - pmid:22908190 + pmid:28901280 - bp(GO:macroautophagy) increases a(GO:autophagosome) + complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) - pmid:22908190 + pmid:28901280 - bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) + bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) - pmid:18930136 + pmid:28901280 - bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") + bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine) - pmid:18930136 + pmid:28901280 - bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) + bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic") - pmid:30116051 + pmid:28901280 - bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007))) + bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) + bp(GO:"secretion by cell") association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) + bp(MESH:Apoptosis) association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine) - pmid:29024336 + pmid:28901280 - bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) + a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) - pmid:26751493 + pmid:28901280 - bp(GO:macroautophagy) decreases p(HGNC:MAPT) + a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") - - - - - pmid:22908190 + pmid:29626319 - a(GO:autophagosome) association a(HBP:"dystrophic neurite") + a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) - pmid:22908190 + pmid:29626319 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") - pmid:22908190 + pmid:28901280 - a(GO:autophagosome) increases a(GO:organelle) + path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") - pmid:22908190 + pmid:28901280 - a(GO:autophagosome) association p(HGNC:APP) + bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") + + + + + + + + + + - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) increases bp(GO:autophagy) + p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") + bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) + a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic") - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) + a(HBP:cytisine) decreases act(a(MESH:Nicotine)) - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") + a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic") - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") + a(MESH:Carbachol) decreases act(a(MESH:Nicotine)) - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) + a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic") - pmid:18930136 + pmid:28901280 - a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) + a(MESH:Varenicline) decreases act(a(MESH:Nicotine)) - pmid:22908190 + pmid:28901280 - a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments") + a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic") - pmid:22908190 + pmid:28901280 - a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin) + a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine)) - pmid:22908190 + pmid:28901280 - a(HBP:"dystrophic neurite") association a(GO:autophagosome) + a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) - pmid:22908190 + pmid:28901280 - a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) - pmid:29758300 + pmid:28901280 - a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") - pmid:18930136 + pmid:28901280 - a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") + a(MESH:Glutamates) increases bp(GO:"action potential initiation") - pmid:18930136 + pmid:27796283 - a(GO:autolysosome) decreases path(HBP:Neurodegeneration) + bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) - pmid:29758300 + pmid:27041503 - bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) + bp(MESH:"Long-Term Potentiation") negativeCorrelation bp(GO:"actin filament polymerization") - pmid:29758300 + pmid:27041503 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Long-Term Potentiation") negativeCorrelation p(HGNC:WWC1) - pmid:22908190 + pmid:27041503 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:memory) - pmid:29758300 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) + bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic") - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) + bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System")) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) + bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System")) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") + bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) + g(DNSNP:rs16969968) association act(a(MESH:Nicotine)) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) + p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) + p(MGI:Chrna5) increases a(MESH:Nicotine) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) + p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) + p(MGI:Chrna2) increases a(MESH:Nicotine) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(Ub)) + a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) + a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic") + + + + + + + + - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:"amyloid-beta") + g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) + g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") - pmid:22908190 + pmid:28901280 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) + bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) - - - pmid:29758300 + pmid:28901280 - p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") + a(MESH:Epithelium) regulates a(MESH:Acetylcholine) - pmid:30116051 + pmid:28901280 - p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) + act(a(MESH:Epithelium)) association p(MGI:Chrna7) - pmid:29758300 + pmid:28901280 - bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) + a(MESH:Choline) increases act(p(HGNC:CHRNA9)) - pmid:22908190 + pmid:28901280 - a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(Ub))) + a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:22908190 + pmid:28901280 - a(GO:lysosome) increases deg(p(HGNC:MAPT)) + a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) - pmid:22908190 + pmid:28901280 - a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:22908190 + pmid:28901280 - act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) - pmid:22908190 + pmid:28901280 - a(GO:lysosome) increases a(GO:organelle) + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) - pmid:18930136 + pmid:28901280 - a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) - pmid:18930136 + pmid:28901280 - act(a(GO:lysosome)) decreases path(HBP:Neurodegeneration) + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) - pmid:18930136 + pmid:30106381 - act(a(GO:lysosome)) increases a(GO:autophagosome) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") - pmid:18930136 + pmid:30106381 - act(a(GO:lysosome)) increases a(GO:lysosome) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") - pmid:18930136 + pmid:30106381 - act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") - pmid:29024336 + pmid:30106381 - a(GO:lysosome) increases deg(a(HBP:HBP00053)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") - pmid:29590627 + pmid:30106381 - a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") - pmid:29590627 + pmid:30106381 - a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) - pmid:29590627 + pmid:30106381 - a(GO:lysosome) association a(HBP:"Tau aggregates") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) - pmid:29590627 + pmid:30106381 - a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") - pmid:24561250 + pmid:30106381 - a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") - pmid:29758300 + pmid:30106381 - p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) - pmid:29758300 + pmid:30106381 - p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) - pmid:22908190 + pmid:30106381 - p(HGNC:MTOR) regulates bp(GO:autophagy) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3) - pmid:29758300 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) decreases bp(GO:"neuron cellular homeostasis") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1) - pmid:29758300 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) decreases a(MESH:Neurons) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA)) - pmid:14556719 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B) - pmid:24457024 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B) - pmid:18930136 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3) - pmid:18930136 + pmid:30106381 - p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4) - - - - - - - - - - - - - - - pmid:29758300 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17) - pmid:18930136 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D) - pmid:29758300 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1) - pmid:29758300 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1) - pmid:23528736 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1) - pmid:29758300 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) - pmid:18930136 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") - pmid:18930136 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Recognition (Psychology)") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) - pmid:14556719 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(Ub))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") - pmid:30116051 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory) - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders") - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries") - pmid:30116051 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated") - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) - pmid:22908190 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) - pmid:18930136 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) - pmid:18930136 + pmid:30664622 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7) - pmid:29626319 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) - pmid:18930136 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") - pmid:18930136 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") - pmid:18930136 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") - pmid:18930136 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") - pmid:30116051 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:23528736 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:25374103 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B) - pmid:30116051 + pmid:30008470 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B) + + - pmid:29626319 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) + p(HGNC:ADNP) association bp(GO:autophagy) - pmid:29626319 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ADNP) association bp(GO:autophagy) - pmid:29626319 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ADNP) association bp(GO:"cell adhesion") - pmid:29626319 + pmid:30106381 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation)) + p(HGNC:ADNP) association bp(GO:"immune response") - pmid:29758300 + pmid:30106381 - bp(GO:proteolysis) decreases bp(GO:"neuron death") + p(HGNC:ADNP) association path(MESH:"Autistic Disorder") - pmid:14556719 + pmid:29724491 - bp(GO:proteolysis) association p(HGNC:UBA3) + p(HGNC:ADNP) decreases path(MESH:"Autistic Disorder") - pmid:29626319 + pmid:30106381 - bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ADNP) association act(a(GO:synapse)) - pmid:29758300 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") decreases a(HBP:"protein aggregates") + p(HGNC:ADNP) association bp(GO:"nervous system development") - pmid:29758300 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP) association bp(GO:"synapse assembly") - pmid:22908190 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP) regulates bp(GO:"synapse organization") - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + p(HGNC:ADNP) regulates bp(GO:"cell communication") - pmid:29758300 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) + p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering") - pmid:29758300 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) association bp(GO:learning) - pmid:18930136 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) association bp(GO:memory) - pmid:18930136 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) increases bp(GO:memory) - pmid:18930136 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) association bp(GO:"social behavior") - pmid:30116051 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) increases bp(GO:"social behavior") - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + p(HGNC:ADNP) regulates bp(GO:"ion transport") - pmid:29758300 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) + p(HGNC:ADNP) association bp(GO:"vocalization behavior") - pmid:22908190 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) + p(HGNC:ADNP) regulates p(HGNC:APOE) - pmid:18930136 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) + p(HGNC:ADNP) association g(HGNC:"IQCJ-SCHIP1") - pmid:24563850 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:ADNP) association p(HGNC:NLGN2) - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) + p(HGNC:ADNP) regulates p(HGNC:PAX6) - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) + p(HGNC:ADNP) association p(HGNC:WFS1) - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:ADNP) association path(MESH:Inflammation) - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) + p(HGNC:ADNP) association path(MESH:Intelligence) - pmid:30116051 + pmid:30106381 - bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) + p(HGNC:ADNP) regulates p(HGNC:MTOR) - pmid:29024336 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders") - pmid:29024336 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated") - pmid:29024336 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") - pmid:29024336 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) + p(HGNC:ADNP) increases a(GO:"dendritic spine") - pmid:29024336 + pmid:30664622 - bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) + act(p(HGNC:ADNP)) association p(HGNC:DLG4) - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability") - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities") - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + p(HGNC:ADNP) increases bp(GO:"motor behavior") + + - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + p(HGNC:ADNP) decreases path(MESH:"Muscle Hypotonia") - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + p(HGNC:ADNP) decreases path(MESH:"Muscle Hypertonia") - pmid:29024336 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") + p(HGNC:ADNP) decreases path(MESH:"Language Development Disorders") - pmid:25374103 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + p(HGNC:ADNP) decreases path(MESH:Seizures) - pmid:29311797 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) + p(HGNC:ADNP) decreases path(MESH:Epilepsy) - pmid:29311797 + pmid:29724491 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) + p(HGNC:ADNP) decreases path(MESH:"Autism Spectrum Disorder") - pmid:29758300 + pmid:29724491 - p(MESH:"Amyloid beta-Peptides", pmod(HBP:misfolding)) increases path(MESH:"Alzheimer Disease") + p(HGNC:ADNP) increases bp(GO:"sensory processing") - - - pmid:29758300 + pmid:29724491 - complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) + p(HGNC:ADNP) decreases path(MESH:"Compulsive Behavior") - pmid:14556719 + pmid:29724491 - complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) + p(HGNC:ADNP) decreases path(MESH:"Mood Disorders") - pmid:14556719 + pmid:29724491 - act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) + p(HGNC:ADNP) decreases path(MESH:Anxiety) - pmid:14556719 + pmid:29724491 - act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) + p(HGNC:ADNP) increases path(MESH:Morale) - pmid:29758300 + pmid:29724491 - act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:ADNP) decreases path(MESH:"Self-Injurious Behavior") - pmid:29626319 + pmid:29724491 - complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") + p(HGNC:ADNP) decreases path(MESH:Aggression) - pmid:29758300 + pmid:29724491 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ADNP) decreases path(MESH:"Attention Deficit Disorder with Hyperactivity") - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ADNP) increases bp(GO:sleep) - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ADNP) decreases path(MESH:"Malformations of Cortical Development") - pmid:29758300 + pmid:29724491 - bp(GO:endocytosis) association p(HGNC:BECN1) + p(HGNC:ADNP) increases path(MESH:"Vision, Ocular") - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) + p(HGNC:ADNP) decreases path(MESH:Hyperopia) - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) increases act(a(MESH:Neurons)) + p(HGNC:ADNP) decreases path(MESH:Strabismus) - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") + p(HGNC:ADNP) decreases path(MESH:Myopia) - pmid:22908190 + pmid:29724491 - bp(GO:endocytosis) increases bp(GO:memory) + p(HGNC:ADNP) decreases path(MESH:Astigmatism) - pmid:22908190 + pmid:27671637 - bp(GO:endocytosis) increases bp(GO:learning) + a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:22908190 + pmid:27807169 - bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") + a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) - pmid:22908190 + pmid:22156579 - bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) + a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4") + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) + a(PUBCHEM:9832404) decreases p(HGNC:DLG4) - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") + a(PUBCHEM:9832404) decreases p(HGNC:DLG4) - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") + a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") + a(PUBCHEM:9832404) increases p(HGNC:DLG4) - pmid:22908190 + pmid:30664622 - bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) + act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") - pmid:22908190 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") - pmid:18930136 + pmid:30106381 - bp(GO:endocytosis) increases a(GO:lysosome) + a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") - pmid:29590627 + pmid:30106381 - bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(PUBCHEM:9832404) association bp(GO:autophagy) - pmid:29590627 + pmid:30106381 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(PUBCHEM:9832404) association bp(GO:"cell adhesion") - pmid:29590627 + pmid:30106381 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(PUBCHEM:9832404) association bp(GO:"immune response") - pmid:28420982 + pmid:30106381 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) + a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") - pmid:29686391 + pmid:30106381 - bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") + a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") - pmid:29758300 + pmid:30106381 - p(HGNC:ATG7) increases bp(GO:macroautophagy) + a(PUBCHEM:9832404) association act(a(GO:synapse)) - pmid:18930136 + pmid:30106381 - p(HGNC:ATG7) decreases path(HBP:Neurodegeneration) + a(PUBCHEM:9832404) association bp(GO:"nervous system development") - - - - - - - pmid:26323690 + pmid:30106381 - bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) + a(PUBCHEM:9832404) association bp(GO:"synapse assembly") - pmid:29758300 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) + a(PUBCHEM:9832404) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") - pmid:28420982 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) + a(PUBCHEM:9832404) regulates bp(GO:"synapse organization") - pmid:29758300 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) + a(PUBCHEM:9832404) regulates bp(GO:"cell communication") - pmid:30116051 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) + a(PUBCHEM:9832404) association bp(GO:"AMPA glutamate receptor clustering") - pmid:30116051 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) + a(PUBCHEM:9832404) association bp(GO:learning) - pmid:30116051 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) + a(PUBCHEM:9832404) association bp(GO:memory) - pmid:29024336 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") + a(PUBCHEM:9832404) association bp(GO:"social behavior") - pmid:24027553 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L")) + a(PUBCHEM:9832404) increases bp(GO:"social behavior") - pmid:24027553 + pmid:30664622 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) + a(PUBCHEM:9832404) increases bp(GO:"social behavior") - pmid:30108137 + pmid:30664622 - path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) + a(PUBCHEM:9832404) increases bp(GO:"social behavior") - pmid:30108137 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) + a(PUBCHEM:9832404) regulates bp(GO:"ion transport") - pmid:30108137 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) + a(PUBCHEM:9832404) association bp(GO:"vocalization behavior") - pmid:30108137 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) + a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) - pmid:28420982 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) - pmid:28420982 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + a(PUBCHEM:9832404) increases p(HGNC:FPR3) - pmid:26751493 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(PUBCHEM:9832404) decreases p(HGNC:TUBB1) - pmid:26751493 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) + a(PUBCHEM:9832404) association p(HGNC:APOE) - pmid:26751493 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) + a(PUBCHEM:9832404) association g(HGNC:"IQCJ-SCHIP1") - pmid:26751493 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) + a(PUBCHEM:9832404) association p(HGNC:NLGN2) - pmid:26751493 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) + a(PUBCHEM:9832404) association p(HGNC:PAX6) - pmid:26631930 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + a(PUBCHEM:9832404) regulates p(HGNC:WFS1) - pmid:8391280 + pmid:30106381 - path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) + a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B) - pmid:29758300 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) + a(PUBCHEM:9832404) decreases p(HGNC:ABCF3) - pmid:22908190 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1") + a(PUBCHEM:9832404) decreases p(HGNC:BMP4) - pmid:26751493 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") + a(PUBCHEM:9832404) decreases p(HGNC:CDH17) - pmid:26631930 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") + a(PUBCHEM:9832404) decreases p(HGNC:KDM5D) - pmid:26751493 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) + a(PUBCHEM:9832404) decreases p(HGNC:KLF1) - pmid:26631930 + pmid:30106381 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + a(PUBCHEM:9832404) decreases p(HGNC:PER1) - pmid:29758300 + pmid:30106381 - p(FPLX:MAPK) increases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:9832404) decreases p(HGNC:AKT1) - pmid:29191965 + pmid:30106381 - p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:9832404) decreases p(HGNC:AIF1) - pmid:8702879 + pmid:30106381 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) + a(PUBCHEM:9832404) regulates p(HGNC:MTOR) - pmid:8702879 + pmid:30106381 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) + a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") - pmid:8702879 + pmid:30106381 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) + a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") - - - - - pmid:29758300 + pmid:30106381 - composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases") - pmid:18930136 + pmid:30106381 - p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + a(PUBCHEM:9832404) increases path(MESH:"Motor Activity") - pmid:30116051 + pmid:30106381 - p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") + a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength") - pmid:30116051 + pmid:30106381 - p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) + a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)") - pmid:29758300 + pmid:30106381 - p(HGNC:NBR1) association p(HGNC:MAPT) + a(PUBCHEM:9832404) increases path(MESH:Smell) - pmid:29758300 + pmid:30664622 - p(HGNC:SNCA, pmod(HBP:misfolding)) increases a(HBP:"alpha-synuclein oligomers") + a(PUBCHEM:9832404) causesNoChange bp(GO:behavior) - pmid:29758300 + pmid:30664622 - a(HBP:"alpha-synuclein oligomers") increases path(HBP:neuroinflammation) + a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders") - pmid:29758300 + pmid:30664622 - a(HBP:"alpha-synuclein oligomers") increases bp(GO:"cell death") + a(PUBCHEM:9832404) decreases path(HBP:Excitotoxicity) - + + + pmid:30664622 + + act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") + - pmid:29758300 + pmid:30664622 - complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") + a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) - pmid:14556719 + pmid:30664622 - p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") + a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) - pmid:28803412 + pmid:30664622 - p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") + a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) - pmid:14556719 + pmid:30664622 - p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") + a(PUBCHEM:9832404) increases r(HGNC:SLC17A7) - + + + pmid:30664622 + + a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7) + - pmid:29758300 + pmid:30008470 - complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") + a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) - pmid:14556719 + pmid:30008470 - p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") + a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) - pmid:28803412 + pmid:30106381 - p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") + p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) - pmid:14556719 + pmid:30664622 - p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") + p(HGNC:DLG4) association act(p(HGNC:ADNP)) - pmid:28803412 + pmid:30106381 - p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") + p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) - pmid:29758300 + pmid:30664622 - p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) - pmid:29758300 + pmid:30106381 - p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") - - - + + + pmid:24760868 + + p(HGNC:DLG4, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + - pmid:29334120 + pmid:26751493 - act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") + p(HGNC:DLG4) association p(HBP:"projection domain") - - - + + + pmid:26751493 + + p(HGNC:DLG4) association a(HBP:"projection domain") + @@ -76532,108 +77251,108 @@

Statements

- pmid:29758300 + pmid:30106381 - a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") - pmid:29758300 + pmid:30664622 - a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) - pmid:29758300 + pmid:30664622 - a(CHEBI:lipid) regulates bp(GO:macroautophagy) + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) - pmid:29758300 + pmid:30008470 - a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") - pmid:29758300 + pmid:30106381 - a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) + bp(GO:"nervous system development") association p(HGNC:ADNP) - pmid:22908190 + pmid:30106381 - a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) + bp(GO:"nervous system development") association a(PUBCHEM:9832404) - pmid:22908190 + pmid:30106381 - a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) + bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP) - pmid:29758300 + pmid:30106381 - path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) + bp(GO:"AMPA glutamate receptor clustering") association a(PUBCHEM:9832404) - pmid:29758300 + pmid:30106381 - path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + bp(GO:"social behavior") association p(HGNC:ADNP) - pmid:29758300 + pmid:30106381 - path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) + bp(GO:"social behavior") association a(PUBCHEM:9832404) - pmid:18930136 + pmid:30106381 - path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + bp(GO:"vocalization behavior") association p(HGNC:ADNP) - pmid:29238289 + pmid:30106381 - path(MESH:Starvation) increases p(HGNC:MAPT) + bp(GO:"vocalization behavior") association a(PUBCHEM:9832404) @@ -76642,13 +77361,6 @@

Statements

- - - pmid:24561250 - - a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) - - @@ -76657,240 +77369,216 @@

Statements

- pmid:29758300 + pmid:21882945 - rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:"amyloid-beta") + p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) - pmid:29758300 + pmid:21882945 - a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) + p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) - - - - - pmid:29758300 + pmid:21367866 - complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) - - - - - pmid:29758300 + pmid:30106381 - complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(HBP:"Tau aggregates") + p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome") - pmid:29758300 + pmid:30106381 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) + g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"calcium-mediated signaling") - pmid:23528736 + pmid:30106381 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) + g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"action potential") - pmid:30116051 + pmid:30106381 - p(FPLX:AMPK) increases bp(GO:macroautophagy) + g(HGNC:"IQCJ-SCHIP1") increases bp(MESH:"Neuronal Outgrowth") - pmid:30116051 + pmid:30106381 - p(FPLX:AMPK) decreases bp(GO:mitophagy) + g(HGNC:"IQCJ-SCHIP1") association p(HGNC:ADNP) - pmid:30116051 + pmid:30106381 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317)) + g(HGNC:"IQCJ-SCHIP1") association a(PUBCHEM:9832404) - pmid:30116051 + pmid:30106381 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777)) + p(HGNC:LIPA) increases bp(GO:"lipid metabolic process") - pmid:30116051 + pmid:22142809 - p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph)) + p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) - pmid:30116051 + pmid:30106381 - p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") + p(HGNC:NLGN2) association a(PUBCHEM:9832404) - pmid:30116051 + pmid:30106381 - act(p(FPLX:AMPK)) increases bp(GO:autophagy) + p(HGNC:NLGN2) association p(HGNC:ADNP) - pmid:30116051 + pmid:30106381 - act(p(FPLX:AMPK)) increases bp(GO:autophagy) + p(HGNC:PAX6) association a(PUBCHEM:9832404) - pmid:23528736 + pmid:30106381 - p(FPLX:AMPK) increases bp(GO:autophagy) + p(HGNC:WFS1) association path(HBP:Neurodegeneration) - - - pmid:30116051 + pmid:30106381 - act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) + p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis") - - - pmid:23528736 + pmid:30106381 - p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) + p(HGNC:WFS1) association p(HGNC:ADNP) - - - pmid:30116051 + pmid:30106381 - p(HGNC:ULK1) increases bp(GO:macroautophagy) + path(MESH:Intelligence) association p(HGNC:ADNP) - - - - - - - pmid:30116051 + pmid:26010758 - act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") + p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") - pmid:30116051 + pmid:30106381 - act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph)) + p(HGNC:MTOR) association bp(GO:translation) - pmid:30116051 + pmid:30106381 - act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph)) + p(HGNC:MTOR) association bp(GO:autophagy) - pmid:23528736 + pmid:29758300 - p(HGNC:ULK1) increases bp(GO:autophagy) + p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) - - - - - pmid:29758300 + pmid:22908190 - composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) + p(HGNC:MTOR) regulates bp(GO:autophagy) - pmid:29758300 + pmid:30106381 - p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MTOR) association a(GO:"actin cytoskeleton") @@ -76899,887 +77587,905 @@

Statements

pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:26751493 + pmid:30106381 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:translation) association p(HGNC:MTOR) - pmid:29758300 + pmid:30106381 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy) + a(GO:"actin cytoskeleton") association p(HGNC:MTOR) - pmid:30145931 + pmid:30106381 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) - pmid:30145931 + pmid:30106381 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:wortmannin) + path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) - pmid:30145931 + pmid:28391535 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:epoxomicin) + path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine) - pmid:29215007 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + path(MESH:Smell) regulates bp(GO:"social behavior") - pmid:29215007 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) - pmid:29215007 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) - pmid:29215007 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) - pmid:25374103 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) + a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") - pmid:26631930 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") - pmid:17493042 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) - pmid:17493042 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:chlorobutanol) decreases path(MESH:Smell) - pmid:21367866 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37) + a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) - pmid:11943212 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph)) + a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) - pmid:11943212 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration") + a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) - pmid:22692785 + pmid:26195256 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle") + a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) - pmid:22156579 + pmid:26195256 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) + act(a(MESH:"Blood-Brain Barrier")) association p(HGNC:PPIA) + + + + - pmid:22156579 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(HBP:"Tau epitope, 12E8") + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) - pmid:23948915 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") - pmid:26118667 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation m(MIRBASE:"rno-mir-195") + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") + + + + - pmid:22833681 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior") + + + + - pmid:22952452 + pmid:30664622 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:Neurodegeneration) + composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) - pmid:29758300 + pmid:30664622 - p(HGNC:TFEB) regulates a(GO:lysosome) + composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) - pmid:29626319 + pmid:30664622 - p(HGNC:TFEB) increases act(a(GO:lysosome)) + p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") - pmid:29626319 + pmid:30664622 - p(HGNC:TFEB) increases act(a(GO:lysosome)) + p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") + + - pmid:29758300 + pmid:29724491 - p(HGNC:TFEB) regulates bp(GO:autophagy) + p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior") - pmid:29758300 + pmid:28167836 - p(HGNC:TFEB) increases bp(GO:autophagy) + path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Arg205del") - pmid:29626319 + pmid:28167836 - p(HGNC:TFEB) increases bp(GO:autophagy) + path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Glu239del") - pmid:29758300 + pmid:30008470 - p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") + path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) - - - pmid:29758300 + pmid:30008470 - p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph))) + path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) - pmid:29626319 + pmid:30008470 - p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) - pmid:29758300 + pmid:30008470 - p(HGNC:TFEB) increases act(p(HGNC:PTEN)) + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) - pmid:28803412 + pmid:30008470 - p(HGNC:TFEB) decreases a(HBP:HBP00093) + path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) - pmid:30116051 + pmid:30008470 - p(HGNC:TFEB) increases bp(GO:macroautophagy) + path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) - pmid:30116051 + pmid:30008470 - tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) - pmid:30116051 + pmid:30008470 - p(HGNC:TFEB) decreases a(HBP:HBP00018) + path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) - pmid:30108137 + pmid:30008470 - p(HGNC:TFEB) decreases act(a(MESH:Lysosomes)) + path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) - pmid:29626319 + pmid:30008470 - p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") + g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") + + + + - pmid:29626319 + pmid:14556719 - p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) + a(GO:microtubule) association p(HGNC:MAPT) - pmid:29626319 + pmid:26631930 - p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) + a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:29626319 + pmid:18930136 - p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") + a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") - pmid:29626319 + pmid:8282104 - p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) + a(GO:microtubule) association p(HGNC:CDK5) - pmid:29758300 + pmid:8282104 - p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB)) + a(GO:microtubule) association p(HGNC:PRKACA) - - - - - pmid:29758300 + pmid:8282104 - complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) + a(GO:microtubule) association p(FPLX:ERK) - pmid:29758300 + pmid:8282104 - complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) + a(GO:microtubule) association p(FPLX:GSK3) - pmid:29758300 + pmid:23487739 - bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + a(GO:microtubule) negativeCorrelation act(p(HGNC:HDAC6)) - pmid:29758300 + pmid:22807490 - bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) + path(MESH:"Hashimoto Disease") association path(MESH:Smoking) - pmid:18930136 + pmid:22807490 - bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) + p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) - pmid:21882945 + pmid:22807490 - bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") + path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) - pmid:21882945 + pmid:22807490 - bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers") + a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") - pmid:29758300 + pmid:23178521 - p(HGNC:PTEN) increases bp(GO:macroautophagy) + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) - - - - - pmid:29758300 + pmid:23178521 - composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) - - - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) positiveCorrelation a(CHEBI:"amyloid-beta") + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases a(CHEBI:"amyloid-beta") + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) - pmid:29626319 + pmid:23178521 - p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) - pmid:29626319 + pmid:23178521 - p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) regulates bp(GO:macroautophagy) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:29758300 + pmid:23178521 - p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:26195256 + pmid:23178521 - p(HGNC:PICALM) association path(MESH:"Alzheimer Disease") + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:29626319 + pmid:23178521 - p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) - pmid:27260836 + pmid:23178521 - p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) - pmid:27260836 + pmid:23178521 - p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) - pmid:27260836 + pmid:23178521 - p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") + a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") + a(PUBCHEM:71311633) causesNoChange a(CHEBI:"amyloid-beta") - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:56972222) causesNoChange a(CHEBI:"amyloid-beta") - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration") + a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) partOf complex(GO:"Pick body") + a(PUBCHEM:11957537) causesNoChange a(CHEBI:"amyloid-beta") - pmid:27260836 + pmid:21958873 - p(HGNC:PICALM) partOf complex(GO:"Cajal body") + a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:27260836 + pmid:23178521 - p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) + a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:27260836 + pmid:23178521 - p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) + a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) - pmid:29758300 + pmid:23178521 - tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(HBP:"Tau aggregates")) + a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) - pmid:29758300 + pmid:23178521 - p(HGNC:BIN1) increases bp(GO:endocytosis) + a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) + + + + + + - pmid:29758300 + pmid:23178521 - p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") + composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) + + + + + + - pmid:29758300 + pmid:23178521 - p(HGNC:BIN1) increases bp(GO:autophagy) + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) - pmid:29758300 + pmid:23383175 - p(HGNC:BIN1) decreases a(CHEBI:"amyloid-beta") + p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:29758300 + pmid:23383175 - p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:29758300 + pmid:23383175 - p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) + p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) + + + + - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) - - - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) increases bp(GO:macroautophagy) + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) increases bp(GO:"metabolic process") + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) increases bp(GO:"metabolic process") + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) - pmid:29758300 + pmid:23178521 - p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) - pmid:26195256 + pmid:23178521 - p(HGNC:TREM2) association path(MESH:"Alzheimer Disease") + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) - pmid:29626319 + pmid:23383175 - p(HGNC:TREM2) association bp(GO:phagocytosis) + p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:29626319 + pmid:23383175 - act(p(HGNC:TREM2)) increases bp(GO:phagocytosis) + p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:29626319 + pmid:23383175 - act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) - - - pmid:29758300 + pmid:23383175 - p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") + p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") - pmid:29758300 + pmid:23383175 - p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) + p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) @@ -77788,1626 +78494,1641 @@

Statements

- pmid:29758300 + pmid:23383175 - p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) + p(MGI:Stat3) regulates bp(GO:"cytokine production") - pmid:29758300 + pmid:23383175 - p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) + path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) - pmid:29758300 + pmid:23383175 - p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) - pmid:29758300 + pmid:23383175 - p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") + path(MESH:Encephalomyelitis) increases p(MGI:Il1b) - pmid:29758300 + pmid:23383175 - p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) - pmid:29758300 + pmid:23383175 - a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") + path(MESH:Encephalomyelitis) increases p(MGI:Ifng) - pmid:27671637 + pmid:23383175 - a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) - pmid:25987199 + pmid:23383175 - act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) + path(MESH:Encephalomyelitis) increases p(MGI:Tnf) - pmid:22952452 + pmid:23383175 - act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:TRAK1) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) - pmid:22952452 + pmid:23383175 - act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:RHOT1) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) - - - - - pmid:18930136 + pmid:23383175 - bp(GO:mitophagy) isA bp(GO:macroautophagy) + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) - pmid:30116051 + pmid:23383175 - bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) - pmid:29758300 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) + path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) + path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) + path(MESH:Encephalomyelitis) increases a(MESH:Microglia) - pmid:26631930 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) + path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) + p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") + p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") + p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + + - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + p(MGI:Rela) regulates bp(GO:"cytokine production") - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) - pmid:27594586 + pmid:23383175 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) - pmid:27594586 + pmid:12428809 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) association path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:21882945 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:22299660 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:29191965 - p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:30145931 - p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(HBP:"amyloid-beta oligomers") - pmid:27594586 + pmid:28784767 - p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") - pmid:27594586 + pmid:18239272 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") - pmid:29024336 + pmid:22817713 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates") - pmid:29191965 + pmid:22817713 - p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers") - pmid:26631930 + pmid:22486774 - p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers") - pmid:26631930 + pmid:14612456 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph)) - pmid:26631930 + pmid:20071522 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph)) - pmid:26631930 + pmid:20071522 - p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:"Tau oligomers") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - - - - - pmid:29758300 + pmid:20071522 - composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5) - pmid:27594586 + pmid:21367866 - composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37) - pmid:29758300 + pmid:17078951 - path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA) - pmid:29758300 + pmid:17078951 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) - pmid:14556719 + pmid:25331948 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo a(HBP:"Tau epitope, CP13") - pmid:14556719 + pmid:26118667 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) negativeCorrelation m(MIRBASE:"rno-mir-195") - pmid:18930136 + pmid:19459590 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13") - pmid:29758300 + pmid:22833681 - path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - pmid:29758300 + pmid:24406748 - a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) - pmid:30116051 + pmid:23294633 - a(CHEBI:Temsirolimus) decreases a(HBP:HBP00006) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:30116051 + pmid:22002427 - a(CHEBI:Temsirolimus) decreases a(HBP:HBP00017) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) - pmid:30116051 + pmid:22002427 - a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:30116051 + pmid:22253473 - a(CHEBI:Temsirolimus) decreases a(HBP:HBP00016) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle") - pmid:30116051 + pmid:16464864 - a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(CHEBI:"okadaic acid") - pmid:30116051 + pmid:16464864 - a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) + p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) - pmid:29626319 + pmid:24653673 - a(CHEBI:Temsirolimus) increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) - pmid:29626319 + pmid:24653673 - a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:17403556 - a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pmid:22253473 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:24653673 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))) - pmid:30145931 + pmid:24653673 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))) - pmid:23528736 + pmid:10391244 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39")) - pmid:29626319 + pmid:10391244 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT)) - pmid:29626319 + pmid:21367866 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37) - pmid:18930136 + pmid:17078951 - a(CHEBI:"alpha,alpha-trehalose") decreases path(HBP:Neurodegeneration) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA) - pmid:30145931 + pmid:23948915 - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") - pmid:30145931 + pmid:26118667 - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation m(MIRBASE:"rno-mir-195") - pmid:29626319 + pmid:22833681 - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo a(HBP:"Tau epitope, AT180") - pmid:30145931 + pmid:19623258 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180") - pmid:23528736 + pmid:22926167 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) + a(HBP:"Tau oligomers") association a(HBP:pretangles) - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) + a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) + a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00006) + a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00016) + a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00017) + a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00018) + a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") + a(HBP:"Tau oligomers") association a(GO:"Pick body") - pmid:30116051 + pmid:27574109 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) - pmid:23528736 + pmid:29686391 - a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) - pmid:29626319 + pmid:28420982 - a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta") + a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) - pmid:29626319 + pmid:28420982 - a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) + a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) - pmid:29311797 + pmid:27574109 - p(HGNC:MAPT, pmod(HBP:misfolding)) increases bp(GO:"cell death in response to oxidative stress") + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:27574109 - p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:25887395 - p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260836 + pmid:28420982 - p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pmid:26631930 - a(CHEBI:paclitaxel) increases a(GO:microtubule) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:27574109 - a(CHEBI:paclitaxel) increases a(GO:microtubule) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:29758300 + pmid:27574109 - a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:22941973 + pmid:28528849 - a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain")) + a(HBP:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") - pmid:22941973 + pmid:28528849 - a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + a(HBP:"Tau oligomers") decreases bp(GO:memory) - pmid:29758300 + pmid:28420982 - a(CHEBI:epothilone) decreases path(MESH:Tauopathies) + a(HBP:"Tau oligomers") decreases bp(GO:memory) - pmid:29758300 + pmid:29191965 - a(CHEBI:epothilone) increases bp(GO:cognition) + a(HBP:"Tau oligomers") decreases a(MESH:Neurons) - - - - - pmid:14556719 + pmid:29686391 - composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) - pmid:22908190 + pmid:22817713 - composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) - pmid:14556719 + pmid:22817713 - act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) + a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) - pmid:22908190 + pmid:29686391 - a(MESH:Ubiquitin) association a(HBP:"paired helical filaments") + a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22908190 + pmid:29686391 - a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") + tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers") - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite") + a(HBP:"Tau oligomers") increases path(MESH:Disease) - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") + a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") + a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) - pmid:22908190 + pmid:22817713 - a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") + a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) association a(GO:"Lewy body") + a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) association a(GO:"Lewy body") + a(HBP:"Tau oligomers") decreases a(GO:synapse) - pmid:22908190 + pmid:22486774 - a(MESH:Ubiquitin) association a(GO:"Pick body") + a(HBP:"Tau oligomers") partOf a(GO:synapse) - pmid:22908190 + pmid:28420982 - act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") - pmid:22908190 + pmid:28420982 - a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24457024 + pmid:26631930 - a(MESH:Ubiquitin) regulates bp(GO:signaling) + a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24457024 + pmid:28420982 - a(MESH:Ubiquitin) regulates bp(GO:endocytosis) + a(HBP:"Tau oligomers") decreases bp(GO:cognition) - pmid:24457024 + pmid:28420982 - a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) + a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") - pmid:24457024 + pmid:28420982 - a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") + a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") - pmid:24457024 + pmid:28420982 - act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") + a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) - - - - - pmid:24457024 + pmid:28420982 - complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils") - pmid:24457024 + pmid:28420982 - complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival") - pmid:14556719 + pmid:28420982 - p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) + a(HBP:"Tau oligomers") association p(HGNC:PRNP) - pmid:14556719 + pmid:28420982 - p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + a(HBP:"Tau oligomers") decreases act(a(GO:microtubule)) - pmid:14556719 + pmid:28420982 - p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) + a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") - pmid:14556719 + pmid:28420982 - act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) - pmid:14556719 + pmid:28420982 - p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub)) + a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") - pmid:24457024 + pmid:28420982 - p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) - - - - - pmid:24457024 + pmid:28420982 - complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) + a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) - pmid:14556719 + pmid:26631930 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration) - pmid:14556719 + pmid:26631930 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") decreases a(MESH:"Dendritic Spines") - pmid:24457024 + pmid:22817713 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") - pmid:24457024 + pmid:22817713 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:24457024 + pmid:22817713 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:14556719 + pmid:22817713 - p(HGNC:UBA3) association bp(GO:proteolysis) + a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:22908190 + pmid:26671985 - p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) + act(a(HBP:"Tau oligomers")) increases a(HBP:neurotoxicity) - pmid:24457024 + pmid:26671985 - p(HGNC:UBA3) increases act(p(HGNC:UBA2)) + act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon)) - pmid:24457024 + pmid:26671985 - p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + act(a(HBP:"Tau oligomers")) positiveCorrelation p(HBP:"phosphatase-activating domain") - pmid:24457024 + pmid:27716675 - p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") + a(HBP:"Tau oligomers") positiveCorrelation a(HBP:neuroinflammation) - + + + pmid:27716675 + + a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading") + - pmid:24457024 + pmid:22299660 - p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:28420982 - p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:26458742 - p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24457024 + pmid:28420982 - p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") - + + + pmid:14612456 + + p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph)) + - pmid:24457024 + pmid:20071522 - complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph)) - - - + + + pmid:20071522 + + p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + - pmid:22908190 + pmid:20071522 - a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5) - pmid:22908190 + pmid:21367866 - a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37) - pmid:24457024 + pmid:17078951 - tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA) - pmid:18930136 + pmid:17078951 - tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) - pmid:14556719 + pmid:22156579 - bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1") - pmid:14556719 + pmid:23948915 - bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") + p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") - pmid:14556719 + pmid:28176663 - bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") - pmid:18930136 + pmid:22833681 - bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - pmid:14556719 + pmid:29844403 - bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B)) - pmid:14556719 + pmid:22299660 - bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:26458742 - bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") + p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:24760868 - bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) - pmid:18930136 + pmid:14612456 - bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:21367866 - bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37) - pmid:14556719 + pmid:17078951 - p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") + p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA) - + + + pmid:17078951 + + p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) + - pmid:22908190 + pmid:11943212 - p(HBP:"20 S Proteasome") increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2") - pmid:22908190 + pmid:22156579 - p(HBP:"20 S Proteasome") increases complex(a(HBP:"Tau aggregates"), p(HBP:"20 S Proteasome")) + p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1") - pmid:16816118 + DOI:10.4172/2168-975X.1000126 - act(p(HBP:"20 S Proteasome")) negativeCorrelation p(RGD:Mapt, pmod(HBP:nitration)) + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) - pmid:16816118 + pmid:25331948 - act(p(HBP:"20 S Proteasome")) negativeCorrelation bp(GO:"neurofibrillary tangle assembly") + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) - + + + pmid:24183963 + + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) + - pmid:14556719 + pmid:29121589 - complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) - pmid:14556719 + pmid:29844403 - p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) - pmid:14556719 + pmid:21734277 - p(HGNC:PSMD4) association p(HGNC:PRKN) + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) - pmid:24457024 + pmid:25331948 - p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) + p(HGNC:GSK3B, pmod(Ph, Ser, 9)) negativeCorrelation act(p(HGNC:SYK)) - pmid:25036637 + DOI:10.4172/2168-975X.1000126 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4)) + p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) - pmid:25036637 + pmid:23454242 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) + p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) - pmid:25036637 + pmid:29121589 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) + p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) - pmid:25036637 + pmid:29121589 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) + p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") - pmid:25036637 + pmid:28391535 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) + sec(a(CHEBI:adrenaline)) increases sec(a(CHEBI:glucose)) - pmid:25036637 + pmid:28391535 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) + sec(a(CHEBI:adrenaline)) increases path(MESH:"Blood Pressure") - pmid:14556719 + pmid:28391535 - p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) + sec(a(CHEBI:adrenaline)) increases bp(GO:"cellular respiration") - + + + pmid:28391535 + + sec(a(CHEBI:adrenaline)) increases bp(MESH:"Heart Rate") + - + + + pmid:22908190 + + a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) + @@ -79417,18 +80138,18 @@

Statements

- pmid:14556719 + pmid:28391535 - deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) + a(CHEBI:"(S)-nicotine") increases path(MESH:Death) - pmid:14556719 + pmid:28391535 - deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) + a(CHEBI:"(R)-nicotine") increases path(MESH:Death) @@ -79437,245 +80158,257 @@

Statements

+ + + + - pmid:14556719 + pmid:28391535 - complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") + a(MESH:Liver) increases bp(GO:"nicotine metabolic process") - pmid:14556719 + pmid:29626319 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") + a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta")) - pmid:14556719 + pmid:29626319 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") + a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") - pmid:14556719 + pmid:29626319 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") + a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") - pmid:14556719 + pmid:29626319 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") + a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:14556719 + pmid:29626319 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") + a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") + bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") + bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine) - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") + a(MESH:Lung) increases bp(GO:"nicotine metabolic process") + + + + + + + + - pmid:14556719 + pmid:26195256 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") + path(MESH:Hypertension) association path(MESH:"Alzheimer Disease") + + + + - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") + a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine)) - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") + a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") + a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) - pmid:14556719 + pmid:28391535 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") + a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:methamphetamine)) + + + + + + + + - pmid:14556719 + pmid:19165623 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") + complex(a(CHEBI:"1-methylpyrrolinium"), a(CHEBI:"nicotinic acid")) increases a(CHEBI:nicotine) - pmid:14556719 + pmid:19165623 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") + a(CHEBI:arginine) increases a(CHEBI:"1-methylpyrrolinium") - pmid:25784053 + pmid:19165623 - bp(GO:"cell division") association p(FPLX:"CCT_complex") + a(CHEBI:ornithine) increases a(CHEBI:"1-methylpyrrolinium") - pmid:25036637 + pmid:19165623 - bp(GO:"gene silencing") association p(HGNC:DCP1A) + a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) - pmid:25036637 + pmid:19165623 - bp(GO:"gene silencing") association p(HGNC:EDC3) + a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) - pmid:25036637 + pmid:19165623 - bp(GO:"gene silencing") association p(HGNC:DDX6) + a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:"1-methylpyrrolinium"))) - pmid:14556719 + pmid:19165623 - bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine) - - - pmid:23746257 - - bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) - - - - - pmid:14556719 - - path(MESH:Cachexia) increases bp(GO:"protein catabolic process") - + - pmid:14556719 + pmid:19165623 - path(MESH:Sepsis) increases bp(GO:"protein catabolic process") + p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid"))) - pmid:14556719 + pmid:19165623 - path(MESH:Acidosis) increases bp(GO:"protein catabolic process") + p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine))) - pmid:14556719 + pmid:19165623 - a(MESH:Denervation) increases bp(GO:"protein catabolic process") + p(HGNC:QPRT) increases a(CHEBI:Anatabine) - pmid:14556719 + pmid:19165623 - p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) + p(HGNC:QPRT) increases a(CHEBI:nicotine) @@ -79684,1619 +80417,1578 @@

Statements

- - - pmid:14556719 - - p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo)) - + - pmid:27716675 + pmid:22020111 - p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:23229893 + pmid:22020111 - p(HGNC:SUMO1) partOf a(GO:lysosome) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:19323834 + pmid:22020111 - p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:18675254 + pmid:22020111 - p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + + - pmid:18675254 + pmid:22020111 - p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) + act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") - pmid:16464864 + pmid:22020111 - p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:16464864 + pmid:24563850 - p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo)) + p(HGNC:NFE2L2) increases bp(HBP:Proteostasis) - pmid:14556719 + pmid:29121589 - p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination") + p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + + - pmid:14556719 + pmid:29121589 - p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) - pmid:22908190 + pmid:24355211 - p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub))) + p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18") - pmid:22908190 + pmid:22020111 - p(MESH:Proteins, pmod(Ub)) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) - - - - - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + a(PUBCHEM:135316034) increases p(HGNC:NFE2L2) - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") + a(PUBCHEM:135316034) increases p(HGNC:SIRT1) - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + a(PUBCHEM:135316034) increases p(HGNC:AKR1B10) - pmid:14556719 + pmid:22020111 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") + a(PUBCHEM:135316034) increases p(HGNC:PTGR1) - pmid:14556719 + pmid:22020111 - a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) increases p(HGNC:HMOX1) - pmid:14556719 + pmid:22020111 - a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) + a(PUBCHEM:135316034) increases p(HGNC:HMOX1) - pmid:14556719 + pmid:22020111 - a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) + a(PUBCHEM:135316034) increases p(HGNC:HMOX1) - - - - - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + a(PUBCHEM:135316034) increases p(HGNC:AIFM2) - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") + a(PUBCHEM:135316034) increases p(HGNC:OSGIN1) - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") + a(PUBCHEM:135316034) increases p(HGNC:GPX3) - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + a(PUBCHEM:135316034) increases p(HGNC:SQSTM1) - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + a(PUBCHEM:135316034) increases p(HGNC:HSPB8) - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") + a(PUBCHEM:135316034) increases p(HGNC:TNFSF9) - pmid:14556719 + pmid:22020111 - a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1) - pmid:14556719 + pmid:22020111 - a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + a(PUBCHEM:135316034) decreases p(HGNC:DHFR) - pmid:14556719 + pmid:22020111 - path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + a(PUBCHEM:135316034) decreases p(HGNC:DHFR) - pmid:14556719 + pmid:22020111 - path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + a(PUBCHEM:135316034) decreases p(HGNC:EDN1) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + a(PUBCHEM:135316034) decreases p(HGNC:ITGB3) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + a(PUBCHEM:135316034) decreases p(HGNC:MKI67) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") + a(PUBCHEM:135316034) decreases p(HGNC:MMP11) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:MMP14) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:MMP2) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:135316034) decreases p(HGNC:PDE7A) - pmid:14556719 + pmid:22020111 - a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") + a(PUBCHEM:135316034) decreases p(HGNC:PDE7B) - pmid:14556719 + pmid:22020111 - a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") + a(PUBCHEM:135316034) decreases p(HGNC:PLAU) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") + a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) - - - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association p(HGNC:PSMD4) + a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) - - - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") + a(PUBCHEM:135316034) decreases p(HGNC:SCARB1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") + a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub)) + a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association p(HGNC:GPR37) + a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) increases p(HGNC:NR3C1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) + a(PUBCHEM:135316034) increases p(HGNC:NR3C1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) regulates p(HGNC:SNCA) + a(PUBCHEM:135316034) increases p(HGNC:PPARA) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco)) + a(PUBCHEM:135316034) increases p(HGNC:PPARA) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) + a(PUBCHEM:135316034) increases p(HGNC:EGR1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) + a(PUBCHEM:135316034) increases p(HGNC:PTGS2) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) + a(PUBCHEM:135316034) increases p(HGNC:PTGS2) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) + a(PUBCHEM:135316034) increases p(HGNC:SOAT1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) + a(PUBCHEM:135316034) decreases p(HGNC:ACLY) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association p(HGNC:CCNE1) + a(PUBCHEM:135316034) decreases p(HGNC:ACLY) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases p(HGNC:CCNE1) + a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") + a(PUBCHEM:135316034) decreases p(HGNC:C20orf27) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) decreases bp(GO:"cell death") + a(PUBCHEM:135316034) decreases p(HGNC:CCNA2) - - - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub)) + a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association a(GO:"actin filament") + a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) regulates act(a(MESH:Actins)) + a(PUBCHEM:135316034) decreases p(HGNC:FEN1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco)) + a(PUBCHEM:135316034) decreases p(HGNC:GINS2) - pmid:22908190 + pmid:22020111 - p(HGNC:PRKN) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:135316034) decreases p(HGNC:MCM10) - pmid:22908190 + pmid:22020111 - p(HGNC:PRKN) increases bp(GO:mitophagy) + a(PUBCHEM:135316034) decreases p(HGNC:MCM4) - pmid:22908190 + pmid:22020111 - p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") + a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A) - pmid:23528736 + pmid:22020111 - p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") + a(PUBCHEM:135316034) decreases p(HGNC:SLIT2) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:SPC25) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) + a(PUBCHEM:135316034) decreases p(HGNC:TFRC) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) + a(PUBCHEM:135316034) decreases p(HGNC:TK1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) + a(PUBCHEM:135316034) decreases p(HGNC:TMEM97) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) + a(PUBCHEM:135316034) decreases p(HGNC:TRIP13) - pmid:28803412 + pmid:22020111 - p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") + a(PUBCHEM:135316034) decreases p(HGNC:TUBB) - pmid:30116051 + pmid:22020111 - p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") + a(PUBCHEM:135316034) decreases p(HGNC:TUBB) - pmid:30116051 + pmid:22020111 - p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) + a(PUBCHEM:135316034) decreases p(HGNC:TYMS) - pmid:30116051 + pmid:22020111 - p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(PUBCHEM:135316034) decreases p(HGNC:TYMS) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + a(PUBCHEM:135316034) decreases p(HGNC:UBA1) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + a(PUBCHEM:135316034) decreases p(HGNC:UNG) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) + a(PUBCHEM:135316034) decreases p(HGNC:UNG) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) + a(PUBCHEM:135316034) decreases p(HGNC:VRK1) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") + a(PUBCHEM:135316034) increases p(HGNC:ABCD3) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) + a(PUBCHEM:135316034) increases p(HGNC:GLRX2) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:135316034) increases p(HGNC:GLRX2) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) + a(PUBCHEM:135316034) increases p(HGNC:MICB) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) + a(PUBCHEM:135316034) increases p(HGNC:NQO1) - pmid:14556719 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) + a(PUBCHEM:135316034) increases p(HGNC:NQO1) - pmid:30126037 + pmid:22020111 - path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") + a(PUBCHEM:135316034) increases p(HGNC:NQO1) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) + a(PUBCHEM:135316034) decreases p(HGNC:AGRN) - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) - - - - - pmid:14556719 + pmid:22020111 - complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:BAX) - - - - - - - pmid:14556719 + pmid:22020111 - complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub)) + a(PUBCHEM:135316034) decreases p(HGNC:BCHE) - pmid:29121589 + pmid:22020111 - p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + a(PUBCHEM:135316034) decreases p(HGNC:BGN) - pmid:14556719 + pmid:22020111 - p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) + a(PUBCHEM:135316034) decreases p(HGNC:BRCA1) - - - - - pmid:14556719 + pmid:22020111 - complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) + a(PUBCHEM:135316034) decreases p(HGNC:CADPS2) - - - - - pmid:14556719 + pmid:22020111 - p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone")) + a(PUBCHEM:135316034) decreases p(HGNC:CAPN1) - pmid:14556719 + pmid:22020111 - p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) + a(PUBCHEM:135316034) decreases p(HGNC:CCNB1) - pmid:14556719 + pmid:22020111 - p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) + a(PUBCHEM:135316034) decreases p(HGNC:CDK1) - - - - - pmid:14556719 + pmid:22020111 - complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) + a(PUBCHEM:135316034) decreases p(HGNC:CDK2) - pmid:29191965 + pmid:22020111 - a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) + a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A) - pmid:14556719 + pmid:22020111 - p(HGNC:GPR37) association p(HGNC:PRKN) + a(PUBCHEM:135316034) decreases p(HGNC:CXCR4) - - - pmid:14556719 + pmid:22020111 - p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) + a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1) - pmid:14556719 + pmid:22020111 - p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") + a(PUBCHEM:135316034) decreases p(HGNC:FOLH1) - pmid:14556719 + pmid:22020111 - p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:135316034) decreases p(HGNC:HOMER1) - pmid:14556719 + pmid:22020111 - bp(GO:"response to unfolded protein") increases bp(GO:"cell death") + a(PUBCHEM:135316034) decreases p(HGNC:HRH1) - pmid:14556719 + pmid:22020111 - bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") + a(PUBCHEM:135316034) decreases p(HGNC:IGF2) - pmid:14556719 + pmid:22020111 - bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") + a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2) - pmid:14556719 + pmid:22020111 - bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") + a(PUBCHEM:135316034) decreases p(HGNC:LDLR) - pmid:23746257 + pmid:22020111 - bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) + a(PUBCHEM:135316034) decreases p(HGNC:MAOA) - pmid:24563850 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) + a(PUBCHEM:135316034) decreases p(HGNC:NEFH) - pmid:24563850 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") decreases bp(HBP:misfolding) + a(PUBCHEM:135316034) decreases p(HGNC:NPDC1) - pmid:24563850 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") + a(PUBCHEM:135316034) decreases p(HGNC:NRGN) - pmid:24563850 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") + a(PUBCHEM:135316034) decreases p(HGNC:PREP) - pmid:24563850 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") + a(PUBCHEM:135316034) decreases p(HGNC:PROS1) - pmid:23702978 + pmid:22020111 - bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) + a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1) - pmid:14556719 + pmid:22020111 - p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) decreases p(HGNC:TAGLN) - - - - - - - pmid:14556719 + pmid:22020111 - composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) + a(PUBCHEM:135316034) decreases p(HGNC:TGFB1) - pmid:14556719 + pmid:22020111 - a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) decreases p(HGNC:VKORC1) - pmid:23531502 + pmid:22020111 - act(a(CHEBI:"hydrogen peroxide")) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + a(PUBCHEM:135316034) increases p(HGNC:CANX) - pmid:23722080 + pmid:22020111 - a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") + a(PUBCHEM:135316034) increases p(HGNC:GCNT2) - pmid:23722080 + pmid:22020111 - a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + a(PUBCHEM:135316034) increases p(HGNC:IDE) - pmid:14556719 + pmid:22020111 - a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) increases p(HGNC:MMP1) - pmid:14556719 + pmid:22020111 - bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) increases p(HGNC:SLC6A6) - pmid:14556719 + pmid:22020111 - bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) increases p(HGNC:SYVN1) - pmid:14556719 + pmid:22020111 - bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") + a(PUBCHEM:135316034) increases p(HGNC:TSHZ1) - pmid:23746257 + pmid:22020111 - bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") + a(PUBCHEM:135316034) increases p(HGNC:TXN) - pmid:23746257 + pmid:22020111 - bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) + a(PUBCHEM:135316034) decreases p(HGNC:ATAD2) - pmid:23746257 + pmid:22020111 - bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis) + a(PUBCHEM:135316034) decreases p(HGNC:BECN1) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) + a(PUBCHEM:135316034) decreases p(HGNC:DHCR24) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) + a(PUBCHEM:135316034) decreases p(HGNC:FGF2) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) + a(PUBCHEM:135316034) decreases p(HGNC:HTRA1) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) + a(PUBCHEM:135316034) decreases p(HGNC:PRKCE) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") + a(PUBCHEM:135316034) decreases p(HGNC:PRKDC) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + a(PUBCHEM:135316034) decreases p(HGNC:SCD) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + a(PUBCHEM:135316034) increases p(HGNC:ATP1A1) - pmid:29807032 + pmid:22020111 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + a(PUBCHEM:135316034) increases p(HGNC:CTSD) - pmid:14556719 + pmid:22020111 - p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN) + a(PUBCHEM:135316034) increases p(HGNC:GLRX) - - - pmid:14556719 + pmid:22020111 - p(HGNC:SNCAIP) association p(HGNC:SNCA) + a(PUBCHEM:135316034) increases p(HGNC:GLRX) - - - - - pmid:14556719 + pmid:22020111 - composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") + a(PUBCHEM:135316034) increases p(HGNC:IL6R) - pmid:14556719 + pmid:22020111 - p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) + a(PUBCHEM:135316034) increases p(HGNC:NPTX1) - pmid:14556719 + pmid:22020111 - p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) + a(PUBCHEM:135316034) increases p(HGNC:PHF1) - - - + + + pmid:22020111 + + a(PUBCHEM:135316034) increases p(HGNC:PRKCD) + - pmid:14556719 + pmid:22020111 - p(HGNC:CCNE1) association p(HGNC:PRKN) + a(PUBCHEM:135316034) increases p(HGNC:RANBP9) - pmid:14556719 + pmid:22020111 - p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") + a(PUBCHEM:135316034) increases p(HGNC:SOD1) - + + + pmid:22020111 + + a(PUBCHEM:135316034) increases p(HGNC:SOD1) + - pmid:14556719 + pmid:22020111 - composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) - pmid:14963027 + pmid:22020111 - bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) - pmid:27068745 + pmid:22020111 - bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - p(HGNC:AIMP2) increases bp(GO:"cell death") + a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") - - - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") + a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:14556719 + pmid:22020111 - p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub)) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport") + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - - - pmid:14556719 + pmid:22020111 - bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub)) + a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:22020111 - a(GO:"actin filament") association p(HGNC:PRKN) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:14556719 + pmid:29121589 - p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) + a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:ERK)) - pmid:14556719 + pmid:29121589 - act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") + a(CHEBI:"dimethyl fumarate") increases act(p(FPLX:p38)) - pmid:22908190 + pmid:29121589 - p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) + a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473)) - + + + pmid:29121589 + + a(CHEBI:"dimethyl fumarate") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + - pmid:14556719 + pmid:29121589 - p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") + a(CHEBI:"dimethyl fumarate") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:14556719 + pmid:29121589 - p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:"dimethyl fumarate") negativeCorrelation p(HGNC:DPYSL2, pmod(Ph)) - pmid:23528736 + pmid:29121589 - p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") + a(CHEBI:"dimethyl fumarate") decreases a(HBP:Astrogliosis) - pmid:23528736 + pmid:29121589 - p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") + a(CHEBI:"dimethyl fumarate") decreases a(HBP:Microgliosis) - + + + pmid:29121589 + + a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) + - pmid:14556719 + pmid:29121589 - p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") + a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) - pmid:14556719 + pmid:29121589 - p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) + a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") - pmid:14556719 + pmid:22020111 - p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") + p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") - pmid:14556719 + pmid:22020111 - p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") + p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:14556719 + pmid:22020111 - p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") + p(HGNC:AKR1B10) increases bp(GO:detoxification) - pmid:22908190 + pmid:22020111 - p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") + p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) - pmid:22908190 + pmid:22020111 - p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") + p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) - - - pmid:22908190 + pmid:22020111 - p(HGNC:UCHL1) increases act(a(GO:synapse)) + p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) - pmid:22908190 + pmid:22020111 - p(HGNC:UCHL1) increases bp(GO:memory) + p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) - pmid:14556719 + pmid:22020111 - p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") + p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) - - - pmid:14556719 + pmid:22020111 - complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") + p(HGNC:SQSTM1) increases bp(GO:autophagy) @@ -81305,204 +81997,215 @@

Statements

pmid:22908190 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:22908190 + pmid:18930136 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease") + p(HGNC:SQSTM1) regulates bp(GO:autophagy) - pmid:22908190 + pmid:18930136 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:14556719 + pmid:18930136 - p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:14556719 + pmid:22020111 - p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") + p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") - pmid:14556719 + pmid:29758300 - p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") + p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) - pmid:14556719 + pmid:29758300 - a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) + p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:14556719 + pmid:29758300 - a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) + p(HGNC:SQSTM1) increases p(HGNC:SYP) - pmid:14556719 + pmid:29758300 - a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) + p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") - pmid:14556719 + pmid:22908190 - a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) + p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") - pmid:14556719 + pmid:18930136 - bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) + p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:14556719 + pmid:18930136 - bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") + p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:14556719 + pmid:18930136 - a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") + p(HGNC:SQSTM1) regulates a(GO:aggresome) - pmid:14556719 + pmid:18930136 - p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN) + p(HGNC:SQSTM1) association a(GO:"Lewy body") - + + + pmid:18930136 + + p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") + - pmid:14556719 + pmid:18930136 - complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) + p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) - + + + pmid:18930136 + + p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(Ub))) + - pmid:14556719 + pmid:18930136 - complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) + p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") - - - pmid:29191965 + pmid:30116051 - p(HGNC:TH) regulates a(CHEBI:dopamine) + p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") - pmid:29191965 + pmid:30116051 - p(HGNC:TH) regulates a(CHEBI:serotonin) + p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:29191965 + pmid:22020111 - p(HGNC:TH) regulates act(p(HGNC:DDC)) + p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) - pmid:14556719 + pmid:27491084 - g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") + p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") - - - pmid:14556719 + pmid:24563850 - p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) + p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") - + + + pmid:24563850 + + p(HGNC:HSPB8) association p(HGNC:EIF2A) + @@ -81512,630 +82215,612 @@

Statements

- pmid:14556719 + pmid:22020111 - complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo)) + complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) - pmid:14556719 + pmid:22020111 - p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") + complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates")) - pmid:14556719 + pmid:23746257 - p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) + p(HGNC:BAG3) increases bp(GO:macroautophagy) - pmid:14556719 + pmid:25036637 - p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) - pmid:14556719 + pmid:25036637 - p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) - - - pmid:29311797 + pmid:25036637 - path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) + p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) - pmid:29311797 + pmid:25036637 - path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) - pmid:14556719 + pmid:25036637 - bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) + p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) - pmid:14556719 + pmid:29626319 - bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) + p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) - pmid:24457024 + pmid:22020111 - bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) + a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:22020111 - p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) + a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") - - - - - - - - - - - pmid:14556719 + pmid:22020111 - g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") + a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - - - pmid:27574109 + pmid:29758300 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau") + a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:27574109 + pmid:14556719 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") + a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + p(HGNC:TNFSF9) increases bp(GO:"T cell activation") - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1) - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:Atherosclerosis) increases p(HGNC:DHFR) - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:Atherosclerosis) increases p(HGNC:EDN1) - pmid:27574109 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + path(MESH:Atherosclerosis) increases p(HGNC:ITGB3) - pmid:29311797 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) + path(MESH:Atherosclerosis) increases p(HGNC:MKI67) - pmid:26195256 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") association path(MESH:"Alzheimer Disease") + path(MESH:Atherosclerosis) increases p(HGNC:MMP11) - pmid:27260836 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") + path(MESH:Atherosclerosis) increases p(HGNC:MMP14) - pmid:22057784 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + path(MESH:Atherosclerosis) increases p(HGNC:MMP2) - pmid:22057784 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(MESH:Atherosclerosis) increases p(HGNC:PDE7A) - pmid:22057784 + pmid:22020111 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) + path(MESH:Atherosclerosis) increases p(HGNC:PDE7B) - - - - - pmid:14556719 + pmid:22020111 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") + path(MESH:Atherosclerosis) increases p(HGNC:PLAU) - pmid:14556719 + pmid:22020111 - a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) + path(MESH:Atherosclerosis) increases p(HGNC:PTGS1) - pmid:14556719 + pmid:22020111 - a(CHEBI:lactacystin) increases bp(GO:"cell death") + path(MESH:Atherosclerosis) increases p(HGNC:SCARB1) - pmid:22908190 + pmid:22020111 - a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") + path(MESH:Atherosclerosis) increases p(HGNC:TUBB3) - pmid:30145931 + pmid:22020111 - a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1) - pmid:23528736 + pmid:22020111 - a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + path(MESH:Atherosclerosis) decreases p(HGNC:PPARA) - pmid:24027553 + pmid:22020111 - a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + path(MESH:Atherosclerosis) increases p(HGNC:EGR1) - pmid:24027553 + pmid:22020111 - a(CHEBI:lactacystin) increases p(HGNC:MAPT) + path(MESH:Atherosclerosis) increases p(HGNC:PTGS2) - pmid:23528736 + pmid:22020111 - a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + path(MESH:Atherosclerosis) increases p(HGNC:SOAT1) - pmid:24027553 + pmid:22020111 - a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY) - pmid:24027553 + pmid:22020111 - a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1) - pmid:14556719 + pmid:22020111 - a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association a(GO:"neurofibrillary tangle") + path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite") + path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HGNC:MAPT) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HGNC:MAPT) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association a(MESH:Ubiquitin) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1) - pmid:22908190 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97) - pmid:26631930 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13) - pmid:26631930 + pmid:22020111 - a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB) - pmid:16566606 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3) - pmid:16566606 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS) - pmid:16566606 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) - pmid:16566606 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG) - pmid:7667312 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S") + path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1) - pmid:7667312 + pmid:22020111 - a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") + path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3) - pmid:8391280 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2) - pmid:8391280 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) + path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2) - pmid:8391280 + pmid:22020111 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) + path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB) - pmid:14556719 + pmid:22020111 - a(MESH:Prions) increases path(MESH:"Prion Diseases") + path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1) - pmid:14556719 + pmid:22020111 - a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") + path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1) - pmid:14556719 + pmid:22020111 - path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") + path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") - pmid:14556719 + pmid:25036637 - path(MESH:"Prion Diseases") increases path(MESH:Dementia) + p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") - pmid:14556719 + pmid:25036637 - path(MESH:"Prion Diseases") increases path(MESH:Death) + p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") @@ -82144,329 +82829,322 @@

Statements

pmid:14556719 - path(MESH:"Prion Diseases") increases bp(GO:"neuron death") + act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:18930136 - path(MESH:"Prion Diseases") increases path(MESH:Gliosis) + p(HGNC:UBA1) increases bp(GO:autophagy) - pmid:14556719 + pmid:18930136 - path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates") + p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") - pmid:14556719 + pmid:29626319 - path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:UBA1) increases deg(a(MESH:Proteins)) - pmid:14556719 + pmid:25673844 - path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:VRK1) isA p(HBP:"CK1 superfamily") - - - - - - - - - pmid:14556719 + pmid:22020111 - complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") + p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") - pmid:14556719 + pmid:22020111 - p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") - pmid:14556719 + pmid:22020111 - p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") + p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:24653673 - p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") + p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:14556719 + pmid:24653673 - p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") + p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:14556719 + pmid:24653673 - p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) - pmid:14556719 + pmid:24653673 - p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) + p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) - pmid:18930136 + pmid:24653673 - p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) + p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:22299660 - p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates") + p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pmid:22299660 - p(HGNC:RNF19A) decreases bp(GO:"cell death") + p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) - pmid:14556719 + pmid:30116051 - p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:CAPN1) decreases bp(GO:autophagy) - pmid:14556719 + pmid:30116051 - p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) + p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) - pmid:14556719 + pmid:12428809 - p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:CDK1) increases p(HGNC:MAPT, pmod(Ph)) - - - - - pmid:14556719 + pmid:10391244 - composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") + act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:14556719 + pmid:10391244 - p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") + p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome")) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c")) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:14556719 + pmid:8282104 - p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:14556719 + pmid:22072628 - p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") + act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) - pmid:25784053 + pmid:8282104 - p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:30116051 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:30116051 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:30116051 + pmid:8282104 - p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - + + + pmid:22072628 + + p(HGNC:CDK2) increases a(HBP:"Tau epitope, AT180") + - pmid:14556719 + pmid:22072628 - p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) + act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) - pmid:14556719 + pmid:22072628 - p(HGNC:HTT) decreases act(complex(GO:"proteasome complex")) + act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) - pmid:14556719 + pmid:29758300 - p(HGNC:HTT) increases bp(GO:"cell cycle arrest") + p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") @@ -82475,36 +83153,36 @@

Statements

- pmid:14556719 + pmid:29758300 - p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") + p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") - pmid:26631930 + pmid:29758300 - p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(Ac, Lys)) + p(HGNC:BECN1) association bp(GO:macroautophagy) - pmid:14556719 + pmid:29758300 - p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") + p(HGNC:BECN1) association bp(GO:endocytosis) - pmid:14556719 + pmid:29758300 - p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") + p(HGNC:BECN1) increases bp(GO:phagocytosis) @@ -82513,400 +83191,426 @@

Statements

- pmid:24457024 + pmid:30116051 - p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) + act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") - - - - - + + + pmid:27260836 + + p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) + - pmid:14556719 + pmid:24027553 - p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) - + + + pmid:24027553 + + act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + - pmid:14556719 + pmid:29626319 - composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates") + p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) - pmid:14556719 + pmid:24027553 - composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") + p(HGNC:HTRA1) association bp(HBP:"APP processing") - + + + pmid:24027553 + + act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) + - pmid:14556719 + pmid:24027553 - composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates") + act(p(HGNC:HTRA1)) association act(a(MESH:Microtubules)) - pmid:14556719 + pmid:24027553 - composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") + act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils")) - pmid:14556719 + pmid:24027553 - a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates") + act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates")) - pmid:14556719 + pmid:22020111 - a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) + p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:23702978 - p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser)) - pmid:29626319 + pmid:22020111 - p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:25374103 + pmid:14556719 - p(FPLX:Caspase) positiveCorrelation path(MESH:Tauopathies) + p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") + + + + + + + + - pmid:25374103 + pmid:24563850 - act(p(FPLX:Caspase)) negativeCorrelation p(HGNC:STUB1) + p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + + - pmid:26631930 + pmid:22020111 - p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) + path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) - pmid:22908190 + pmid:22020111 - bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) - pmid:22908190 + pmid:22020111 - bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) - pmid:22908190 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) + bp(GO:phosphorylation) regulates bp(GO:"cell division") - pmid:24027553 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:phosphorylation) regulates bp(GO:"cell growth") - pmid:26631930 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) + bp(GO:phosphorylation) regulates bp(GO:"cell development") - pmid:29626319 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) + bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process") - pmid:26631930 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation") - pmid:26631930 + pmid:23454242 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(Ub))) + bp(GO:phosphorylation) regulates bp(GO:"apoptotic process") - pmid:26631930 + pmid:21882945 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63))) + bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers") - - - + + + pmid:25784053 + + bp(GO:"cell division") association p(FPLX:"CCT_complex") + - pmid:22908190 + pmid:23454242 - composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) + p(FPLX:PPP2) regulates bp(GO:"glycolytic process") - pmid:22908190 + pmid:23454242 - act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") + p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process") - pmid:22908190 + pmid:23454242 - act(p(HGNC:VCP)) regulates a(GO:autophagosome) + p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process") - pmid:24457024 + pmid:23454242 - p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") + p(FPLX:PPP2) regulates bp(GO:"cell cycle") - pmid:24457024 + pmid:23454242 - p(HGNC:VCP) increases bp(GO:"protein ubiquitination") + p(FPLX:PPP2) regulates bp(GO:"DNA replication") - pmid:22908190 + pmid:23454242 - path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated") - pmid:22908190 + pmid:23454242 - path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + p(FPLX:PPP2) regulates bp(GO:translation) - pmid:22908190 + pmid:23454242 - a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) + p(FPLX:PPP2) regulates bp(GO:"signal transduction") - pmid:22817713 + pmid:23454242 - a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") + p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") - pmid:18239272 + pmid:23454242 - a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8") + p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") - pmid:22908190 + pmid:23454242 - bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") + p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") - pmid:22908190 + pmid:23454242 - bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") + p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) regulates bp(GO:"cell motility") - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) regulates bp(GO:"apoptotic process") - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) regulates bp(GO:"apoptotic process") - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic") - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) association path(MESH:Neoplasms) - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) decreases path(MESH:Neoplasms) - pmid:22908190 + pmid:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments") + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms) - pmid:22908190 + pmid:22299660 - p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) association a(HBP:"paired helical filaments") + p(FPLX:PPP2) association path(MESH:Neoplasms) @@ -82919,318 +83623,325 @@

Statements

- pmid:26751493 + pmid:23454242 - p(HBP:"Tau aggregates") association a(CHEBI:heparin) + p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(Ph)) - pmid:26751493 + pmid:23454242 - p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:26751493 + pmid:22299660 - p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + - pmid:26751493 + pmid:23454242 - p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) + act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Me)) + + - pmid:19517062 + pmid:23454242 - p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process") + act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Ph)) + + + + - pmid:19517062 + pmid:23454242 - p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death") + p(FPLX:PPP2) decreases p(FPLX:AKT, pmod(Ph, Thr, 308)) - pmid:28760828 + pmid:23454242 - p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) + p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway") - pmid:28500862 + pmid:23454242 - p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta") + p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(Ph)) - pmid:22908190 + pmid:23454242 - a(GO:"Lewy body") association a(MESH:Ubiquitin) + p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1)) - pmid:22908190 + pmid:23454242 - a(GO:"Lewy body") association a(MESH:Ubiquitin) + p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(Ph)) - pmid:22908190 + pmid:23454242 - a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) + p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(Ph)) + + - pmid:22908190 + pmid:12428809 - a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) + p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:22299660 - a(GO:"Lewy body") association p(HGNC:MAPT) + p(FPLX:PPP2) association a(MESH:Cytosol) - pmid:18930136 + pmid:22299660 - a(GO:"Lewy body") association p(HGNC:SQSTM1) + p(FPLX:PPP2) association a(MESH:"Cell Nucleus") - - - - - pmid:22908190 + pmid:22299660 - a(GO:"Pick body") association p(HGNC:MAPT) + p(FPLX:PPP2) association a(MESH:Mitochondria) - pmid:27574109 + pmid:22299660 - a(GO:"Pick body") association p(HGNC:MAPT) + p(FPLX:PPP2) association a(MESH:Cytoskeleton) - pmid:22908190 + pmid:22299660 - a(GO:"Pick body") association a(MESH:Ubiquitin) + p(FPLX:PPP2) association a(MESH:"Cell Membrane") - pmid:27574109 + pmid:22299660 - a(GO:"Pick body") association a(HBP:"Tau oligomers") + p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia") - pmid:27574109 + pmid:22299660 - a(GO:"Pick body") association a(HBP:"phosphatase-activating domain") + act(p(FPLX:PPP2)) negativeCorrelation a(HBP:"paired helical filaments") - pmid:22908190 + pmid:22299660 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:22908190 + pmid:22299660 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 242)) - pmid:22908190 + pmid:22299660 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") + act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5)) - pmid:22908190 + pmid:22299660 - path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1)) - pmid:26631930 + pmid:22299660 - path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) + act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B)) - pmid:22908190 + pmid:22299660 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pmid:22299660 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:14612456 + pmid:22299660 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2) + p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") - pmid:14612456 + pmid:23943618 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) - pmid:8391280 + pmid:27068745 - p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) + act(p(FPLX:PPP2), ma(kin)) positiveCorrelation p(HGNC:UNC5B) - pmid:25378699 + pmid:27068745 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT)) + act(p(FPLX:PPP2), ma(kin)) increases act(p(HGNC:DAPK1)) - pmid:24905733 + pmid:23454242 - p(HGNC:MAPT, pmod(Ub)) negativeCorrelation act(p(HGNC:MAPT)) + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) - - - - - + + + pmid:23454242 + + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) + - pmid:22908190 + pmid:23454242 - complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub)) + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) - pmid:24457024 + pmid:29311797 - complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) - pmid:22908190 + pmid:23454242 - p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") + path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2) @@ -83241,9 +83952,9 @@

Statements

- pmid:22908190 + pmid:22299660 - complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(HBP:"20 S Proteasome")) + p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease") @@ -83252,12 +83963,7 @@

Statements

- - - pmid:22908190 - - complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) - + @@ -83265,239 +83971,229 @@

Statements

- - - pmid:22908190 - - complex(a(GO:"proteasome regulatory particle"), a(HBP:"paired helical filaments")) decreases act(complex(GO:"proteasome complex")) - + - - - pmid:22908190 - - p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation)) increases p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation), pmod(Ub)) - + - - - pmid:22908190 - - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") - + - - - pmid:23528736 - - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") - + + + + + + + + + - pmid:22908190 + pmid:23454242 - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") + + - pmid:22908190 + pmid:19277525 - p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) - pmid:22908190 + pmid:19277525 - p(HBP:"UBB+1") decreases bp(GO:memory) + p(HGNC:PPP2CA) increases complex(GO:"protein phosphatase type 2A complex") - pmid:23528736 + pmid:24653673 - p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") + p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + - pmid:23528736 + pmid:24653673 - p(HBP:"UBB+1") decreases bp(GO:"protein deubiquitination") + p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pmid:26631930 - p(HBP:"UBB+1") decreases act(p(FPLX:Proteasome)) + act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pmid:24653673 - p(HBP:"UBB+1") increases bp(HP:Neurodegeneration) + deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) - pmid:23528736 + pmid:24653673 - p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") + p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:23528736 + pmid:29191965 - p(HBP:"UBB+1") increases act(p(HGNC:TP53)) + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:26631930 - p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:26631930 - p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly))) + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:29062069 - p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") + act(p(HGNC:PPP2CA)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + + - pmid:22908190 + pmid:29626319 - p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") + p(HGNC:PPP2CA) increases bp(GO:autophagy) - pmid:22908190 + pmid:10464280 - p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) + p(HGNC:PPP2CA) association complex(GO:microtubule) - pmid:22908190 + pmid:10464280 - p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(Ub))) + p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) - pmid:22908190 + pmid:29228318 - p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - - - - - - - - - - - pmid:22908190 + pmid:19401603 - p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:PPP2CA)) positiveCorrelation act(p(HGNC:PIN1)) - pmid:22908190 + pmid:19401603 - deg(p(FPLX:PKA, pmod(Ub))) increases act(p(FPLX:PKA)) + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:22908190 + pmid:19401603 - p(HGNC:ARC) regulates bp(GO:"synapse maturation") + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) - pmid:22908190 + pmid:23454242 - bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) + p(HGNC:PPP2CB) association a(MESH:Cytosol) - pmid:22908190 + pmid:23454242 - act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) + p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus") @@ -83506,266 +84202,265 @@

Statements

- - - - - pmid:22908190 + pmid:24653673 - complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) - - - + + + pmid:24653673 + + p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + - pmid:22908190 + pmid:24653673 - complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") + deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) - pmid:22908190 + pmid:24653673 - a(GO:caveola) increases bp(GO:"plasma membrane invagination") + p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(Ph)) + + - pmid:22908190 + pmid:23454242 - bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") + a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) - pmid:29590627 + pmid:22299660 - bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") + a(MESH:"Cell Membrane") association p(FPLX:PPP2) - pmid:29590627 + pmid:21339331 - bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") + a(MESH:"Cell Membrane") association p(HGNC:ANXA2) - pmid:22908190 + pmid:21339331 - p(HGNC:RAB7A) increases a(GO:endosome) + a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) - pmid:22908190 + pmid:23454242 - p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Cytosol) association p(HGNC:PPP2CB) - pmid:22908190 + pmid:23454242 - p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + a(MESH:Cytosol) association p(HGNC:PPP2R2A) - pmid:22908190 + pmid:23454242 - p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") + a(MESH:Cytosol) association p(HGNC:PPP2R2B) - pmid:18930136 + pmid:23454242 - p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") + a(MESH:Cytosol) association p(HGNC:PPP2R5A) - - - pmid:29238289 + pmid:23454242 - p(HGNC:RAB7A) association p(HGNC:MAPT) + a(MESH:Cytosol) association p(HGNC:PPP2R5B) - pmid:22908190 + pmid:23454242 - act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") + a(MESH:Cytosol) association p(HGNC:PPP2R5E) - pmid:22908190 + pmid:23454242 - act(a(GO:endosome)) decreases path(HBP:Neurodegeneration) + a(MESH:Cytosol) association p(HGNC:PPP2R5D) - pmid:22908190 + pmid:22299660 - complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + a(MESH:Cytosol) association p(FPLX:PPP2) - pmid:22908190 + pmid:23454242 - p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB) - pmid:22908190 + pmid:23454242 - a(MESH:Cathepsins) regulates deg(a(CHEBI:"amyloid-beta")) + a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C) - pmid:22908190 + pmid:23454242 - sec(a(MESH:Cathepsins)) increases bp(GO:"apoptotic process") + a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D) - pmid:22908190 + pmid:22299660 - p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + a(MESH:"Cell Nucleus") association p(FPLX:PPP2) - pmid:22908190 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") - pmid:22908190 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) - pmid:18930136 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) - pmid:29626319 + pmid:19277525 - bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) + act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) @@ -83774,1266 +84469,1279 @@

Statements

- - - pmid:22908190 + pmid:23454242 - complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) + p(HGNC:PPP2R2A) association a(MESH:Cytosol) - pmid:29024336 + pmid:23454242 - a(GO:"late endosome") increases deg(p(MGI:Mapt)) + p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) - pmid:29024336 + pmid:23454242 - a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") - pmid:29024336 + pmid:22299660 - a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + p(HGNC:PPP2R2A) association a(MESH:Brain) - pmid:29590627 + pmid:22299660 - a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29590627 + pmid:23454242 - a(GO:"late endosome") association a(HBP:"Tau aggregates") + p(HGNC:PPP2R2B) association a(MESH:Cytosol) - - - - - pmid:22908190 + pmid:23454242 - complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) + p(HGNC:PPP2R2B) increases bp(GO:cytokinesis) - pmid:29590627 + pmid:23454242 - a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") - pmid:29590627 + pmid:23454242 - a(GO:"early endosome") association a(HBP:"Tau aggregates") + p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton) - pmid:18930136 + pmid:23454242 - a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) + p(HGNC:PPP2R2C) increases bp(GO:cytokinesis) - pmid:22908190 + pmid:23454242 - a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) + p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") - pmid:22908190 + pmid:19277525 - bp(GO:"response to nutrient") regulates p(HGNC:MTOR) + p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - pmid:22908190 + pmid:19277525 - bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") + p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - pmid:22908190 + pmid:19277525 - bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") + p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain") - pmid:22908190 + pmid:19277525 - bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") + p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) - pmid:22908190 + pmid:19277525 - bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) + p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) - pmid:22908190 + pmid:19277525 - bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) + p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:22908190 + pmid:24653673 - bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) + p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:22908190 + pmid:19277525 - a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") + p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) - pmid:27574109 + pmid:19277525 - a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") + p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:27574109 + pmid:24653673 - a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") + p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pmid:24653673 - a(HBP:"Braak_Stage II") association p(HGNC:MAPT) + p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) - pmid:28176663 + pmid:23454242 - a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:PPP2R5A) association a(MESH:Cytosol) - - - pmid:22908190 + pmid:23454242 - p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PPP2R5B) association a(MESH:Cytosol) - pmid:22908190 + pmid:21882945 - p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:23454242 - p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") + p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus") - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) + p(HGNC:PPP2R5D) association a(MESH:Cytosol) - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) + p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus") + + - pmid:22908190 + pmid:24653673 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") + p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") + p(HGNC:PPP2R5E) association a(MESH:Cytosol) - pmid:22908190 + pmid:28720530 - act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex") - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C) - pmid:22908190 + pmid:22299660 - act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) + a(MESH:Cytoskeleton) association p(FPLX:PPP2) + + + + - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta") + composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) - pmid:22908190 + pmid:24027553 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") + composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) + + + + - pmid:22908190 + pmid:23454242 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") + complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(Ph)) - pmid:30116051 + pmid:23454242 - act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) + p(FPLX:Cohesin, pmod(Ph)) increases bp(GO:"spindle disassembly") + + - pmid:27607061 + pmid:23454242 - act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2)) + p(HGNC:SET) decreases act(p(FPLX:PPP2)) - pmid:27607061 + pmid:22299660 - act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") + p(HGNC:SET) decreases act(p(FPLX:PPP2)) - pmid:22908190 + pmid:24653673 - p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:22908190 + pmid:24653673 - p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:22908190 + pmid:24653673 - p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") + p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:22908190 + pmid:24653673 - p(HGNC:ATP6V0A1, pmod(NGlyco)) increases bp(GO:"pH reduction") + p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) - - - - - - - - - - - pmid:22908190 + pmid:24653673 - complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1)) increases act(p(HGNC:RAB5A)) + p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) - pmid:22908190 + pmid:24653673 - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pmid:22299660 - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:22908190 + pmid:23454242 - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) - pmid:22908190 + pmid:23454242 - bp(GO:"response to acidic pH") increases a(HBP:"amyloid-beta oligomers") + a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C)) - pmid:30116051 + pmid:19277525 - p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:26631930 + pmid:24653673 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:26631930 + pmid:24653673 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:26631930 + pmid:19277525 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) - pmid:26631930 + pmid:19277525 - p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration) + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) - pmid:29626319 + pmid:24653673 - p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) + a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) - pmid:22908190 + pmid:24653673 - p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) + a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) - pmid:22908190 + pmid:24653673 - p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") + a(CHEBI:"okadaic acid") decreases bp(GO:cognition) - pmid:22908190 + pmid:24653673 - p(HGNC:RIN1) decreases bp(GO:"fear response") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph)) - pmid:22908190 + pmid:24653673 - p(HGNC:RIN1) decreases bp(GO:memory) + a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis) - pmid:22908190 + pmid:24653673 - p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") + a(CHEBI:"okadaic acid") decreases a(GO:synapse) - pmid:22908190 + pmid:24653673 - sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis) + a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration) - pmid:22908190 + pmid:22299660 - p(HGNC:CST3) decreases act(a(GO:synapse)) + a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2)) - pmid:24563850 + pmid:22299660 - a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 189)) - pmid:21882945 + pmid:22299660 - a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:21882945 + pmid:22299660 - a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:23746257 + pmid:16464864 - act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") + a(CHEBI:"okadaic acid") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:23746257 + pmid:22299660 - act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:23746257 + pmid:22299660 - bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:23746257 + pmid:22299660 - bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:23746257 + pmid:22299660 - bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:23746257 + pmid:22299660 - bp(GO:"protein refolding") association act(p(FPLX:HSP90)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - - - - - pmid:23746257 + pmid:22299660 - complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") + a(CHEBI:"okadaic acid") decreases bp(GO:learning) - pmid:23746257 + pmid:22299660 - bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) + a(CHEBI:"okadaic acid") decreases bp(GO:memory) - pmid:23746257 + pmid:16464864 - bp(GO:"protein secretion") association p(FPLX:HSP90) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) - pmid:23746257 + pmid:23454242 - bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) + a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2)) - pmid:23746257 + pmid:24653673 - p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) + a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) - - - + + + pmid:24653673 + + a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) + - pmid:23746257 + pmid:24653673 - composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") + a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) - pmid:21882945 + pmid:23454242 - p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:microcystin) decreases act(p(FPLX:PPP2)) - + + + pmid:23454242 + + a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2)) + - pmid:23746257 + pmid:23454242 - complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") + a(PUBCHEM:4162) decreases act(p(FPLX:PPP2)) - + + + pmid:23454242 + + a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2)) + - pmid:23746257 + pmid:24653673 - complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) - + + + pmid:24653673 + + a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) + - pmid:23746257 + pmid:24653673 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) + a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) - pmid:23746257 + pmid:23454242 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2)) - pmid:25784053 + pmid:23454242 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + a(PUBCHEM:71361092) increases path(MESH:Neoplasms) - pmid:29311797 + pmid:23454242 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2)) - pmid:25784053 + pmid:23454242 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) + p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) - pmid:23746257 + pmid:23454242 - p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) - pmid:21882945 + pmid:23454242 - p(HGNC:CDC37) regulates act(p(FPLX:HSP90)) + a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C)) - pmid:21367866 + pmid:23454242 - p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) + p(FPLX:PPP2, pmod(Me)) association act(p(FPLX:PPP2)) - pmid:25036637 + pmid:19277525 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(FPLX:PPP2, pmod(Me)) regulates bp(GO:"cell cycle") - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) + p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) + p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) + p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) + p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Me)) association bp(GO:"one-carbon metabolic process") - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation a(CHEBI:homocysteine) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) association p(HGNC:FKBP5) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:25036637 + pmid:24653673 - p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:APP, pmod(Ph)) - pmid:21882945 + pmid:24653673 - p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + p(FPLX:PPP2, pmod(Me)) regulates bp(HBP:"APP processing") - pmid:29311797 + pmid:24653673 - p(HGNC:CDC37) increases p(HGNC:MAPT) + p(FPLX:PPP2, pmod(Me)) regulates bp(MESH:"Neuronal Outgrowth") - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) + p(FPLX:PPP2, pmod(Me)) regulates p(HGNC:MAPT) - pmid:21367866 + pmid:23454242 - p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) + p(FPLX:PPP2, pmod(Ph)) association act(p(FPLX:PPP2)) - pmid:21367866 + pmid:23454242 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2)) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(FPLX:PPP2, pmod(Ph, Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:21367866 + pmid:23454242 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:19277525 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:19277525 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21367866 + pmid:24653673 - p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:23746257 + pmid:23943618 - p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:21882945 + pmid:29281045 - p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:29311797 + pmid:19277525 - p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) - pmid:21882945 + pmid:19277525 - p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) - pmid:21882945 + pmid:24653673 - p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) - pmid:29311797 + pmid:24653673 - p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) - pmid:29311797 + pmid:24653673 - p(HGNC:AHSA1) increases a(HBP:"Tau oligomers") + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) - pmid:29311797 + pmid:24653673 - p(HGNC:AHSA1) increases bp(GO:"neuron apoptotic process") + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) - pmid:29311797 + pmid:24653673 - p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") + p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) - pmid:29311797 + pmid:24653673 - p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") + p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me)) - pmid:23746257 + pmid:23454242 - bp(GO:"behavioral response to starvation") association bp(HBP:Proteostasis) + p(FPLX:PPP2, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) - pmid:23746257 + pmid:23454242 - p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") + p(FPLX:AKT, pmod(Ph, Thr, 308)) increases act(p(FPLX:AKT)) - pmid:23746257 + pmid:23454242 - p(FPLX:Proteasome) increases bp(GO:"protein unfolding") + p(HGNC:CTNNB1, pmod(Ph)) increases bp(GO:"Wnt signaling pathway") - pmid:25784053 + pmid:23454242 - p(FPLX:Proteasome) increases bp(MESH:Proteolysis) + p(HGNC:BAD, pmod(Ph)) decreases bp(GO:"apoptotic process") - pmid:25784053 + pmid:23454242 - p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:BCL2, pmod(Ph)) decreases bp(GO:"apoptotic process") - pmid:25784053 + pmid:19277525 - act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") - pmid:30145931 + pmid:19277525 - act(p(FPLX:Proteasome)) decreases path(HBP:neurotoxicity) + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") - pmid:30145931 + pmid:19277525 - act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") - pmid:30145931 + pmid:19277525 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262))) + complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) - pmid:30145931 + pmid:19277525 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356))) + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") - - - + + + pmid:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") + @@ -85043,403 +85751,369 @@

Statements

- pmid:23746257 + pmid:24653673 - composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) - pmid:23746257 + pmid:19277525 - p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") - pmid:25036637 + pmid:19277525 - p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) + complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:25036637 + pmid:19277525 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) - pmid:25036637 + pmid:24653673 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) + complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:25036637 + pmid:24653673 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21882945 + pmid:24653673 - p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") + act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21882945 + pmid:24653673 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) - pmid:21882945 + pmid:24653673 - p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) - pmid:17954934 + pmid:24653673 - p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) - pmid:17954934 + pmid:24653673 - p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) - pmid:17954934 + pmid:24653673 - p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) - pmid:17954934 + pmid:24653673 - p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17954934 + pmid:24653673 - p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23746257 + pmid:24653673 - a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23746257 + pmid:24653673 - a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) + act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) - pmid:23746257 + pmid:24653673 - a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(Ph)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) - - - pmid:23746257 + pmid:24653673 - p(FPLX:EIF2B, pmod(Ph)) decreases act(p(FPLX:EIF2B)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) - pmid:23746257 + pmid:24653673 - a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) - pmid:25784053 + pmid:24653673 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) - pmid:30116051 + pmid:24653673 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(Ph, Tyr, 307)) - pmid:21882945 + pmid:24653673 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") - pmid:21882945 + pmid:24653673 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) - pmid:30116051 + pmid:24653673 - a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) - pmid:30116051 + pmid:24653673 - a(CHEBI:geldanamycin) decreases a(HBP:HBP00016) + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) - pmid:24027553 + pmid:24653673 - a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) - pmid:21882945 + pmid:10464280 - a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) + act(complex(GO:"protein phosphatase type 2A complex")) association p(HBP:"microtubule-binding region") - - - - - pmid:23746257 + pmid:10464280 - composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") + act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) - pmid:23746257 + pmid:28720530 - composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(HBP:"huntingtin aggregates") + complex(GO:"protein phosphatase type 2A complex") negativeCorrelation p(HBP:"APOE e4") - - - - - pmid:24457024 + pmid:19277525 - complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:24457024 + pmid:19277525 - complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:24457024 + pmid:19277525 - p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - - - - - - - - - pmid:24457024 + pmid:19277525 - p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") - - - - - pmid:24457024 + pmid:19277525 - path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") - pmid:24457024 + pmid:19277525 - p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - - - - - pmid:24457024 + pmid:19277525 - complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:24457024 + pmid:19277525 - p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - - - - - pmid:24457024 + pmid:24653673 - complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases act(complex(GO:"protein phosphatase type 2A complex")) - - - - - pmid:24457024 + pmid:24653673 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24457024 + pmid:24653673 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) - pmid:24457024 + pmid:24653673 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") negativeCorrelation path(MESH:"Alzheimer Disease") @@ -85448,194 +86122,217 @@

Statements

+ + - pmid:24457024 + pmid:19277525 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24457024 + pmid:24653673 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24457024 + pmid:24653673 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24457024 + pmid:24653673 - a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - + + + pmid:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + - pmid:24457024 + pmid:24653673 - complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - + + + pmid:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + - pmid:24457024 + pmid:24653673 - complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me)) - pmid:24457024 + pmid:24653673 - complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) - pmid:25784053 + pmid:24653673 - p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:25784053 + pmid:24653673 - p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule) - pmid:25784053 + pmid:24653673 - p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth") - pmid:26041011 + pmid:24653673 - act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24457024 + pmid:24653673 - act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") - + + + pmid:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + - pmid:24457024 + pmid:19277525 - p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:25036637 + pmid:19277525 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") - pmid:25036637 + pmid:19277525 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:25036637 + pmid:19277525 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:25036637 + pmid:24653673 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:24457024 + pmid:24653673 - p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) + + + + + + - pmid:24457024 + pmid:19277525 - p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:24457024 + pmid:19277525 - act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(Ph)) @@ -85644,47 +86341,52 @@

Statements

- - - pmid:24457024 - - complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) - + + + + + - pmid:25784053 + pmid:19277525 - bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis) + p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) - pmid:25784053 + pmid:19277525 - bp(MESH:Proteolysis) association bp(HBP:Proteostasis) + p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + + + + + + - pmid:29311797 + pmid:19277525 - bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") + p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) - pmid:25784053 + pmid:19277525 - bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis) + p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) @@ -85697,939 +86399,1080 @@

Statements

- pmid:25784053 + pmid:19277525 - complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25784053 + pmid:24653673 - p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25036637 + pmid:19277525 - p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - pmid:25784053 + pmid:19277525 - a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) - pmid:25784053 + pmid:19277525 - bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - pmid:25784053 + pmid:19277525 - a(MESH:Lysosomes) increases bp(MESH:Proteolysis) + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) - pmid:25784053 + pmid:19277525 - a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) - pmid:24027553 + pmid:19277525 - a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(HGNC:PPP2CA)) - pmid:29238289 + pmid:24653673 - act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") - pmid:25784053 + pmid:24653673 - bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:23943618 - bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) + p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) - pmid:25784053 + pmid:19277525 - p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1)) + p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) - + + + pmid:19277525 + + p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + - pmid:25784053 + pmid:19277525 - complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) + p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) - - - pmid:25784053 + pmid:29228318 - act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph)) + p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA)) + + + + - pmid:25784053 + pmid:24653673 - act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) + complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + + - pmid:25784053 + pmid:19277525 - p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25784053 + pmid:19277525 - act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25784053 + pmid:19277525 - bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25784053 + pmid:24653673 - bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin)) + act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25784053 + pmid:19277525 - p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) - pmid:25784053 + pmid:19277525 - p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") + p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) - pmid:25784053 + pmid:19277525 - p(HGNC:PRSS1) decreases p(HGNC:ATF6) + p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) - pmid:25784053 + pmid:19277525 - p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") + p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:24653673 - p(HGNC:PRSS2) decreases p(HGNC:ATF6) + p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:24653673 - p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") + p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) - pmid:25784053 + pmid:24653673 - tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) + p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) - pmid:25784053 + pmid:22299660 - act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") + p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(Me)) - pmid:25784053 + pmid:19277525 - act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) + p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) + + + + - pmid:25784053 + pmid:19277525 - p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) + p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") - pmid:23702978 + pmid:19277525 - p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) + p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) + + + + + + + + - pmid:25784053 + pmid:19277525 - act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4) + p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) - pmid:25784053 + pmid:19277525 - p(HGNC:ATF4) increases p(HGNC:DDIT3) + p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) - pmid:25784053 + pmid:19277525 - p(HGNC:DDIT3) increases bp(GO:"apoptotic process") + a(CHEBI:"microcystin-LR") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:23702978 + pmid:19277525 - p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") + a(CHEBI:"microcystin-LR") decreases act(p(HGNC:PPME1)) - pmid:23702978 + pmid:29228318 - p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me)) + + + + + + + + - pmid:25784053 + pmid:19277525 - p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") + + - pmid:25784053 + pmid:19277525 - p(MGI:Atg5) decreases bp(HP:Neurodegeneration) + p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") - pmid:25784053 + pmid:19277525 - p(MGI:Atg7) decreases bp(HP:Neurodegeneration) + p(INTERPRO:"EF-hand domain") association p(HGNC:PPP2R3A) + + + + + + + + + + + + + + + + + + + + - pmid:24027553 + pmid:19277525 - p(MGI:Atg7) decreases path(HBP:Neurodegeneration) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24027553 + pmid:19277525 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + + + + + + + + + + - pmid:24027553 + pmid:19277525 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) + p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:24027553 + pmid:19277525 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + - pmid:24027553 + pmid:19277525 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:25784053 + pmid:19277525 - p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") + complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") + + + + - pmid:29238289 + pmid:19277525 - p(HGNC:RAB1A) association p(HGNC:MAPT) + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) - pmid:25784053 + pmid:19277525 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine") + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) - pmid:25784053 + pmid:19277525 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) - pmid:25784053 + pmid:19277525 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) - pmid:25784053 + pmid:19277525 - p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) - pmid:24027553 + pmid:19277525 - p(HGNC:MAP1LC3A) positiveCorrelation path(MESH:"Plaque, Amyloid") + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25784053 + pmid:19277525 - a(CHEBI:chloroquine) decreases bp(GO:autophagy) + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + + + + + + - pmid:25784053 + pmid:19277525 - a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine") + composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:24653673 - a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) + p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") - pmid:25784053 + pmid:24653673 - a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) + p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:24027553 + pmid:24653673 - a(CHEBI:chloroquine) increases p(HGNC:MAPT) + p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:24027553 + pmid:24653673 - a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) + a(CHEBI:"S-adenosyl-L-methionine") increases act(p(HGNC:LCMT1)) - pmid:25784053 + pmid:24653673 - a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) + a(CHEBI:"S-adenosyl-L-homocysteine") decreases act(p(HGNC:LCMT1)) + + + + - pmid:21882945 + pmid:24653673 - a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:21882945 + pmid:24653673 - a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + - pmid:25784053 + pmid:24653673 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + - pmid:21882945 + pmid:24653673 - a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:21882945 + pmid:24653673 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:29311797 + pmid:24653673 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:21367866 + pmid:24653673 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) - pmid:30116051 + pmid:24653673 - a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta") + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) association p(FPLX:PPP2, pmod(Me)) - pmid:30116051 + pmid:24653673 - a(CHEBI:tanespimycin) increases bp(GO:memory) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) positiveCorrelation p(FPLX:PPP2, pmod(Me)) - pmid:30116051 + pmid:24653673 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:Tauopathies) - pmid:30116051 + pmid:24653673 - a(CHEBI:tanespimycin) decreases a(HBP:HBP00016) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21882945 + pmid:24653673 - a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21882945 + pmid:24653673 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:21882945 + pmid:24653673 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates a(GO:microtubule) - pmid:29311797 + pmid:24653673 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) regulates bp(MESH:"Neuronal Outgrowth") - pmid:25784053 + pmid:24653673 - a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25784053 + pmid:24653673 - a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) increases bp(GO:macroautophagy) + p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) decreases bp(GO:macroautophagy) + p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) decreases bp(GO:mitophagy) + p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) increases act(complex(GO:"protein phosphatase type 2A complex")) - - - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757)) + p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) + p(HGNC:PPP2CA, pmod(Ub)) increases deg(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) + p(HGNC:PPP2CA, pmod(HBP:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) + p(HGNC:PPP2R5A, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:PPP2R5D, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pmid:24653673 - p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") + p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) - pmid:23528736 + pmid:24653673 - p(FPLX:mTORC1) decreases bp(GO:autophagy) + p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:23528736 + pmid:24653673 - act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph)) + p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) - pmid:23528736 + pmid:24653673 - act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) + p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + - pmid:30108137 + pmid:24653673 - p(FPLX:mTORC1) increases p(MGI:Tfeb, pmod(Ph)) + complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) + complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:10521421) increases bp(GO:autophagy) + complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(CHEBI:fluphenazine) increases bp(GO:autophagy) + complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) + complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) + complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) + complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:799645) increases bp(GO:autophagy) + complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates") + complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:24653673 - a(PUBCHEM:877863) increases bp(GO:autophagy) + a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:24653673 - a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:29758300 - a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") + a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25784053 + pmid:24653673 - a(PUBCHEM:1560402) increases bp(GO:autophagy) + a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:25784053 + pmid:21882945 - a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates") + complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") @@ -86640,9 +87483,9 @@

Statements

- pmid:25784053 + pmid:24653673 - composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") @@ -86653,9 +87496,9 @@

Statements

- pmid:25784053 + pmid:24653673 - composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") @@ -86666,681 +87509,741 @@

Statements

- pmid:25784053 + pmid:24653673 - composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:675434) decreases p(HGNC:MAPT) + complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + + - pmid:23528736 + pmid:24653673 - a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:25784053 + pmid:24653673 - a(PUBCHEM:675434) decreases p(HGNC:TARDBP) + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:25784053 + pmid:24653673 - a(PUBCHEM:675434) decreases p(HGNC:ATXN3) + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + - pmid:25784053 + pmid:24653673 - a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:23528736 + pmid:24653673 - a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:25784053 + pmid:24653673 - a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + + + + + + + + + + + + + + + - pmid:23528736 + pmid:24653673 - a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) + g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:24653673 - bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") + r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:22299660 - bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) + r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:24653673 - bp(GO:"cellular protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24653673 - bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) + r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:22299660 - bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) + r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24653673 - bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) + r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27671637 + pmid:24653673 - bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) + r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:18930136 + pmid:24653673 - deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") + path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - pmid:18930136 + pmid:29758300 - bp(GO:"antigen processing and presentation") association bp(GO:autophagy) + path(MESH:Tauopathies) association p(HGNC:MAPT) - pmid:18930136 + pmid:29758300 - bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") + path(MESH:Tauopathies) association path(MESH:Dementia) - pmid:18930136 + pmid:29758300 - bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) - pmid:18930136 + pmid:30145931 - bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:18930136 + pmid:29024336 - bp(GO:pexophagy) isA bp(GO:macroautophagy) + path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") - pmid:18930136 + pmid:24027553 - bp(GO:reticulophagy) isA bp(GO:macroautophagy) + path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:18930136 + pmid:27574109 - bp(GO:xenophagy) isA bp(GO:macroautophagy) + path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") - pmid:18930136 + pmid:29686391 - bp(GO:ribophagy) isA bp(GO:macroautophagy) + path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") - pmid:18930136 + pmid:27574109 - bp(GO:aggrephagy) isA bp(GO:macroautophagy) + path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") - - - - - pmid:18930136 + pmid:21734277 - a(GO:phagophore) increases a(GO:autophagosome) + path(MESH:Tauopathies) association p(HBP:"AT8 tau", pmod(Ph)) - - - - - pmid:18930136 + pmid:30108137 - composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) + path(MESH:Tauopathies) increases p(MGI:Tfeb) - pmid:18930136 + pmid:30108137 - composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) + path(MESH:Tauopathies) increases p(MGI:Tfeb) - - - - - pmid:18930136 + pmid:30108137 - complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) + path(MESH:Tauopathies) increases p(MGI:Lamp1) - pmid:18930136 + pmid:30108137 - complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) + path(MESH:Tauopathies) increases p(MGI:Ctsd) - pmid:18930136 + pmid:21882945 - p(HGNC:ATG5) decreases path(HBP:Neurodegeneration) + path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") - - - - - - - pmid:18930136 + pmid:28420982 - complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) + path(MESH:Tauopathies) association bp(GO:"neuron death") - - - - - pmid:18930136 + pmid:21882945 - p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) + path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) - pmid:18930136 + pmid:30126037 - p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) + path(MESH:Tauopathies) association bp(GO:"cellular senescence") - pmid:18930136 + pmid:30126037 - p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) + path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") - - - + + + pmid:22419736 + + path(MESH:Tauopathies) association a(CHEBI:"amyloid-beta polypeptide 42") + - + + + pmid:29191965 + + path(MESH:Tauopathies) association p(HGNC:WNT2) + - pmid:18930136 + pmid:29191965 - composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) + path(MESH:Tauopathies) association p(HGNC:TTBK2) - - - + + + pmid:29191965 + + path(MESH:Tauopathies) association p(HGNC:GSK3B) + - + + + pmid:29191965 + + path(MESH:Tauopathies) association p(HGNC:TAOK1) + - pmid:18930136 + pmid:29191965 - complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) + path(MESH:Tauopathies) association p(HGNC:CTSE) - + + + pmid:29191965 + + path(MESH:Tauopathies) association p(HGNC:CHRNA7) + - pmid:18930136 + pmid:25374103 - complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) + path(MESH:Tauopathies) positiveCorrelation p(FPLX:Caspase) - + + + pmid:28420982 + + path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils") + - pmid:18930136 + pmid:26631930 - p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - + + + pmid:26631930 + + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + - + + + pmid:26631930 + + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + - + + + pmid:26631930 + + path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) + - pmid:18930136 + pmid:24653673 - complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) + p(FPLX:PPP2, pmod(Me, Tyr, 307)) association a(GO:"neurofibrillary tangle") - pmid:18930136 + pmid:24653673 - complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) + p(FPLX:PPP2, pmod(Me, Tyr, 307)) association p(HGNC:MAPT, pmod(Ph)) - - - + + + pmid:24653673 + + p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + - pmid:18930136 + pmid:24653673 - path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) + p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") - pmid:18930136 + pmid:24653673 - path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) + p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:18930136 + pmid:24653673 - p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") + p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) - - - pmid:18930136 + pmid:22908190 - p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") + p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) - pmid:18930136 + pmid:29626319 - p(HGNC:ATP13A2, var("?")) increases path(HBP:Neurodegeneration) + p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) - - - pmid:18930136 + pmid:29626319 - p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") + p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) - pmid:18930136 + pmid:24653673 - a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") + p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") - pmid:26631930 + pmid:24653673 - act(a(MESH:Dyneins)) association p(HGNC:MAPT) + p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) - pmid:18930136 + pmid:24653673 - p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) + p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) - - - pmid:8391280 + pmid:24653673 - p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") + p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) - pmid:8391280 + pmid:24653673 - p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) - pmid:8391280 + pmid:24653673 - p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:18930136 + pmid:24653673 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) - pmid:30116051 + pmid:24653673 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) - pmid:29626319 + pmid:24653673 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:18930136 + pmid:24653673 - a(CHEBI:"lithium(1+)") decreases path(HBP:Neurodegeneration) + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) - pmid:30116051 + pmid:24653673 - a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) - pmid:30116051 + pmid:24653673 - a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) - pmid:30116051 + pmid:24653673 - a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) - pmid:30116051 + pmid:24653673 - a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) + + + + - pmid:30116051 + pmid:25374103 - a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) + complex(a(GO:microtubule), p(HGNC:MAPT)) decreases p(HGNC:MAPT, pmod(HBP:misfolded)) - pmid:30116051 + pmid:26631930 - a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) + complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") - pmid:30116051 + pmid:26631930 - a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") + complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") - pmid:18930136 + pmid:26631930 - bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) + complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(HBP:"Tau aggregates") - pmid:18930136 + pmid:26631930 - a(GO:aggresome) negativeCorrelation bp(GO:"cell death") + complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") @@ -87351,1029 +88254,956 @@

Statements

- pmid:18930136 + pmid:24653673 - composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") + bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(Me)) - pmid:18930136 + pmid:24653673 - composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(Ub)) + bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) regulates bp(GO:autophagy) + bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) increases bp(GO:autophagy) + bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668)) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(GO:"one-carbon metabolic process") decreases bp(GO:cognition) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) regulates a(GO:aggresome) + bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta")) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(Me)) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") + a(CHEBI:folates) increases p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") + a(CHEBI:folates) increases p(HGNC:APP, pmod(Ph)) - pmid:18930136 + pmid:24653673 - p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") + path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me)) - pmid:28803412 + pmid:24653673 - p(HGNC:HDAC6) decreases a(HBP:HBP00093) + path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph)) - pmid:30640040 + pmid:24653673 - p(HGNC:HDAC6) association a(PUBCHEM:53340666) + path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph)) - pmid:29311797 + pmid:24653673 - p(HGNC:HDAC6) increases act(p(HGNC:AIP)) + a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(Me)) - pmid:29311797 + pmid:24653673 - p(HGNC:HDAC6) association a(HBP:"Tau aggregates") + a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:26751493 + pmid:24653673 - p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") + a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(Ph)) - pmid:26631930 + pmid:28632203 - p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(Ac, Lys)) + a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:26323690 - p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") + bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) - pmid:25031639 + pmid:12428809 - act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8") + p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(Ph)) - pmid:24844691 + pmid:12428809 - act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac)) + p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(Ph)) - pmid:25546293 + pmid:26631930 - act(p(HGNC:HDAC6)) negativeCorrelation p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:23487739 + pmid:26631930 - act(p(HGNC:HDAC6)) negativeCorrelation a(GO:microtubule) + p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:23487739 + pmid:21311567 - act(p(HGNC:HDAC6)) decreases p(INTERPRO:"Tubulin/FtsZ, GTPase domain", pmod(Ac)) + act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:28760828 + pmid:22952452 - p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT) + act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:28760828 + pmid:21311567 - p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) + act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") - pmid:29844403 + pmid:22952452 - act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MARK1) negativeCorrelation p(HGNC:TRAK1) - pmid:18930136 + pmid:22952452 - p(HGNC:WDFY3) regulates bp(GO:autophagy) + p(HGNC:MARK1) negativeCorrelation p(HGNC:RHOT1) - pmid:18930136 + pmid:12428809 - p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:27796283 - p(HGNC:WDFY3) regulates a(GO:aggresome) + p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) - pmid:18930136 + pmid:12428809 - tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") + p(FPLX:CK2) increases p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:12428809 - p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") + p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:18930136 + pmid:12428809 - bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) + p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24563850 + pmid:12428809 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) + p(HBP:"4R tau") increases path(MESH:"Wallerian Degeneration") - pmid:24563850 + pmid:12428809 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") + p(HBP:"4R tau") increases path(MESH:"Muscular Atrophy") - pmid:24563850 + pmid:12428809 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive nitrogen species") + p(HBP:"4R tau") increases path(HP:Neurodegeneration) - pmid:24563850 + pmid:12428809 - a(CHEBI:radical) association bp(GO:"detection of redox state") + p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:24563850 + pmid:12428809 - a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") + p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24563850 + pmid:26631930 - a(CHEBI:radical) regulates bp(MESH:Metabolism) + p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:24563850 + pmid:26751493 - a(CHEBI:radical) decreases a(MESH:Antioxidants) + p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") - pmid:24563850 + pmid:26631930 - a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") + p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") - pmid:24563850 + pmid:26751493 - a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") + p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") - pmid:24563850 + pmid:26751493 - a(CHEBI:radical) increases bp(HBP:misfolding) + p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24563850 + pmid:26631930 - a(CHEBI:radical) increases bp(GO:"protein oxidation") + p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24563850 + pmid:26631930 - a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") + p(HBP:"4R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"4R tau")) - pmid:24563850 + pmid:23407988 - act(p(HGNC:XDH)) increases a(CHEBI:radical) + p(HBP:"4R tau") isA p(HGNC:MAPT) - pmid:24563850 + pmid:23407988 - act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") + p(HBP:"4R tau") partOf a(HBP:pretangles) - pmid:24563850 + pmid:23407988 - act(p(HGNC:XDH)) increases a(CHEBI:"reactive nitrogen species") + p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle") - pmid:24563850 + pmid:23407988 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) + p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") - pmid:24563850 + pmid:23407988 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") + p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") - pmid:24563850 + pmid:23407988 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive nitrogen species") + p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") - pmid:24563850 + pmid:23407988 - act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) + p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") - pmid:24563850 + pmid:23407988 - act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive oxygen species") + p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") - pmid:24563850 + pmid:23407988 - act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive nitrogen species") + p(HBP:"4R tau") partOf complex(GO:"neuronal cell body") - pmid:24563850 + pmid:23407988 - bp(GO:"response to radiation") increases a(CHEBI:radical) + p(HBP:"4R tau") partOf complex(GO:dendrite) - pmid:24563850 + pmid:23407988 - a(MESH:"Air Pollution") increases a(CHEBI:radical) + p(HBP:"4R tau") partOf a(MESH:Neuropil) - pmid:24563850 + pmid:28775333 - bp(GO:"detection of redox state") association a(CHEBI:radical) + p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) - pmid:24563850 + pmid:21427723 - bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) + p(HBP:"4R tau") partOf path(HBP:"4R tauopathy") - pmid:24563850 + pmid:27574109 - bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) + p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain") - pmid:24563850 + pmid:12428809 - bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding) + a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:24563850 + pmid:12428809 - p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") + a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons) - pmid:24563850 + pmid:12428809 - bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") + a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments") - pmid:24563850 + pmid:27671637 - p(HGNC:EIF2A) association p(HGNC:HSPB8) + a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:24563850 + pmid:12428809 - bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) + p(HBP:"3R tau") increases a(HBP:"straight filaments") - - - - - - - pmid:24563850 + pmid:26751493 - p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) + p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") - - - - - - - pmid:29626319 + pmid:26631930 - tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta") + p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") - pmid:24563850 + pmid:26631930 - p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) + p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:24563850 + pmid:26631930 - act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) + p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau")) - pmid:29121589 + pmid:23407988 - p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + p(HBP:"3R tau") isA p(HGNC:MAPT) - pmid:29121589 + pmid:23407988 - p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27") + p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") - - - - - pmid:24563850 + pmid:23407988 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) + p(HBP:"3R tau") partOf a(HBP:"ghost tangles") - pmid:24563850 + pmid:23407988 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) + p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") - pmid:24563850 + pmid:23407988 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) + p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") - pmid:24563850 + pmid:23407988 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) + p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") - pmid:24563850 + pmid:23407988 - bp(GO:"protein oxidation") association bp(GO:aging) + p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") - pmid:24563850 + pmid:23407988 - bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") + p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") - pmid:24563850 + pmid:23407988 - bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) + p(HBP:"3R tau") partOf complex(GO:dendrite) - pmid:24563850 + pmid:23407988 - bp(GO:"protein oxidation") association path(MESH:Neoplasms) + p(HBP:"3R tau") partOf a(MESH:Neuropil) - pmid:29024336 + pmid:23407988 - bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) + p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") - pmid:24563850 + pmid:26655600 - path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") + p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") - pmid:26195256 + pmid:26655600 - path(MESH:"Cardiovascular Diseases") association path(MESH:"Alzheimer Disease") + p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") - pmid:24563850 + pmid:28775333 - bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") + p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) - pmid:24563850 + pmid:28775333 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") + p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") - pmid:24563850 + pmid:12428809 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(HBP:misfolding) + a(HBP:"straight filaments") association path(MESH:"Alzheimer Disease") - pmid:24563850 + pmid:12428809 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau") - pmid:24563850 + pmid:22299660 - act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") + path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2) - - - + + + pmid:29758300 + + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) + - pmid:25036637 + pmid:28420982 - p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) - pmid:25036637 + pmid:29758300 - p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) - pmid:21882945 + pmid:30116051 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) - pmid:21882945 + pmid:30116051 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") + path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) - pmid:21882945 + pmid:30116051 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) + path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) - pmid:21882945 + pmid:29024336 - p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) + path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") - pmid:21882945 + pmid:24027553 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L")) - pmid:21882945 + pmid:24027553 - p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) - pmid:21882945 + pmid:30108137 - act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) + path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) - pmid:21882945 + pmid:30108137 - act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) - pmid:18500754 + pmid:30108137 - p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) + path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) - pmid:25036637 + pmid:30108137 - p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") + path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) - pmid:29844403 + pmid:28420982 - act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:25036637 + pmid:28420982 - p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) - - - - - - - - - - - - - - - - - - - pmid:25036637 + pmid:26751493 - p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - - - - - - - pmid:25036637 + pmid:26751493 - p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) - - - - - - - pmid:25036637 + pmid:26751493 - p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) - - - - - - - pmid:25036637 + pmid:26751493 - p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) - - - - - - - - - - - pmid:25036637 + pmid:26751493 - p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) - pmid:25036637 + pmid:26631930 - p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) - - - - - - - - - - - - - pmid:25036637 + pmid:8391280 - p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) @@ -88384,24 +89214,18 @@

Statements

- pmid:25036637 + pmid:24027553 - complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) + act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1)) - - - - - - - pmid:25036637 + pmid:29238289 - p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) + act(a(MESH:Microtubules)) association p(HGNC:MAPT) @@ -88412,1013 +89236,814 @@

Statements

- pmid:25036637 + pmid:25374103 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) + bp(GO:"anterograde axonal transport") negativeCorrelation p(HGNC:MAPT) - pmid:25036637 + pmid:25374103 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) + bp(GO:"anterograde axonal transport") decreases a(GO:microtubule) - pmid:25036637 + pmid:25374103 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) + bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) - pmid:25036637 + pmid:12428809 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) + p(HGNC:APPL) increases bp(GO:"anterograde axonal transport") - pmid:25036637 + pmid:20133804 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) + bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) - pmid:25036637 + pmid:19459590 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) + bp(GO:"microtubule polymerization") positiveCorrelation act(p(HGNC:MAPT)) - pmid:25036637 + pmid:22299660 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) + a(MESH:Mitochondria) association p(FPLX:PPP2) - pmid:25036637 + pmid:30126037 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) + act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") - - - pmid:25036637 - - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) - + - pmid:25036637 + pmid:22299660 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) + a(HBP:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2)) - pmid:25036637 + pmid:14556719 - p(HGNC:FKBP5) association p(HGNC:CDC37) + a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) + a(HBP:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) + a(HBP:"paired helical filaments") association a(GO:"neurofibrillary tangle") - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) association p(HGNC:EGLN1) + a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite") - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) association p(HGNC:PDCD2) + a(HBP:"paired helical filaments") association p(HGNC:MAPT) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) association p(HGNC:ANKMY2) + a(HBP:"paired helical filaments") association p(HGNC:MAPT) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) + a(HBP:"paired helical filaments") association a(MESH:Ubiquitin) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) - pmid:25036637 + pmid:22908190 - p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) - pmid:21882945 + pmid:22908190 - p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) - pmid:21882945 + pmid:22908190 - p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) - pmid:20071522 + pmid:22908190 - p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) - pmid:21882945 + pmid:22908190 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) - pmid:20071522 + pmid:22908190 - p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) - pmid:21882945 + pmid:22908190 - p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) + a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) - pmid:21882945 + pmid:26631930 - p(HGNC:FKBP5) increases p(HGNC:MAPT) + a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:20071522 + pmid:26631930 - p(HGNC:FKBP5) increases p(HGNC:MAPT) + a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394)) - pmid:21882945 + pmid:16566606 - p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph)) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - pmid:29311797 + pmid:16566606 - p(HGNC:FKBP5) isA a(MESH:Immunophilins) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:20071522 + pmid:16566606 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) - pmid:20071522 + pmid:16566606 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) - pmid:20071522 + pmid:7667312 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S") - pmid:20071522 + pmid:7667312 - p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) + a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") - pmid:20071522 + pmid:8391280 - p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) - pmid:20071522 + pmid:8391280 - p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) - - - - - - - - - - - - - - - - - - - - - pmid:29686391 + pmid:8391280 - p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) - - - - - - - - - - - - - - - - - - - pmid:26631930 + pmid:22299660 - p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + p(HGNC:MAPT, pmod(Ph, Ser, 189)) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25036637 + pmid:22299660 - p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:26458742 - p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:20071522 - p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph)) - - - - - pmid:25036637 + pmid:20071522 - p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - - - - - - - - - pmid:25036637 + pmid:20071522 - bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5) - pmid:25036637 + pmid:21367866 - bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37) - pmid:25036637 + pmid:17078951 - p(HGNC:EGLN1) association p(HGNC:FKBP5) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA) - pmid:25036637 + pmid:25331948 - p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") + p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") - pmid:25036637 + pmid:19459590 - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) + p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") - pmid:25036637 + pmid:22299660 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:29191965 - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:26751493 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:26751493 - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates") - pmid:25036637 + pmid:26631930 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?")) - - - - - pmid:25036637 + pmid:22817713 - p(HGNC:PDCD2) association p(HGNC:FKBP5) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") - pmid:25036637 + pmid:26671985 - p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") + p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") - - - - - pmid:25036637 + pmid:26671985 - p(HGNC:ANKMY2) association p(HGNC:FKBP5) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction") - pmid:25036637 + pmid:17078951 - p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA) - - - - - - - - - - - - - pmid:25036637 + pmid:18239272 - p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") + p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle") - pmid:25036637 + pmid:18239272 - p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") + p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads") - pmid:25036637 + pmid:18239272 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid") - pmid:25036637 + pmid:18239272 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) - pmid:25036637 + pmid:11943212 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422") - pmid:25036637 + pmid:26118667 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) negativeCorrelation m(MIRBASE:"rno-mir-195") - pmid:25036637 + pmid:23294633 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:25036637 + pmid:27373205 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain") - pmid:25036637 + pmid:27373205 - p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers") - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:23702978 + pmid:27373205 - bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) + p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport") - pmid:25036637 + pmid:22299660 - p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:29758300 - p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29311797 + pmid:26751493 - p(HGNC:FKBP8) isA a(MESH:Immunophilins) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:25036637 + pmid:29758300 - p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy) - pmid:25036637 + pmid:30145931 - p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"amyloid-beta oligomers") - pmid:25036637 + pmid:30145931 - bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:wortmannin) - pmid:25036637 + pmid:30145931 - p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(CHEBI:epoxomicin) - pmid:25036637 + pmid:29215007 - p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:29311797 + pmid:29215007 - p(HGNC:FKBP6) isA a(MESH:Immunophilins) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") - - - - - pmid:25036637 + pmid:29215007 - a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") - pmid:25036637 + pmid:29215007 - p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) - - - - - pmid:25036637 + pmid:25374103 - p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) - pmid:25036637 + pmid:26631930 - bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:21882945 + pmid:17493042 - bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - - - - - - - - - pmid:25036637 + pmid:17493042 - p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:25036637 + pmid:21367866 - p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37) - - - - - - - - - pmid:25036637 + pmid:11943212 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MARK4, pmod(Ph)) - pmid:25036637 + pmid:11943212 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:"granulovacuolar degeneration") - pmid:25036637 + pmid:22692785 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle") - pmid:25036637 + pmid:22156579 - p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) - - - pmid:25036637 + pmid:22156579 - p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(HBP:"Tau epitope, 12E8") - pmid:25036637 + pmid:23948915 - p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) + p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") - - - - - pmid:25036637 + pmid:26118667 - p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation m(MIRBASE:"rno-mir-195") - pmid:25036637 + pmid:22833681 - p(HGNC:DCP1A) association bp(GO:"gene silencing") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - - - - - pmid:25036637 + pmid:22952452 - p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") + p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation a(HBP:Neurodegeneration) - pmid:25036637 + pmid:22299660 - p(HGNC:EDC3) association bp(GO:"gene silencing") + p(FPLX:PPP2C, pmod(Me)) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) @@ -89427,240 +90052,238 @@

Statements

+ + - pmid:25036637 + pmid:22299660 - p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") + p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(Me)) - pmid:25036637 + pmid:22299660 - p(HGNC:DDX6) association bp(GO:"gene silencing") + p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:22299660 - complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4) + p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) increases act(p(FPLX:PPP2)) - pmid:25036637 + pmid:22299660 - complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala")) + p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:22299660 - complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) + p(FPLX:PPP2C, pmod(Me, Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:22299660 - p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) + p(FPLX:PPP2C, pmod(Me, Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) - pmid:25036637 + pmid:22299660 - p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body") + p(FPLX:PPP2C, pmod(Ph)) association a(MESH:"Neurofibrillary Tangles") - pmid:25036637 + pmid:28083634 - p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body") + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ub)) - - - - - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) + p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) + p(HGNC:OTUB1) negativeCorrelation a(HBP:"Tau aggregates") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) + p(HGNC:OTUB1) regulates p(HGNC:MAPT) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) + p(HGNC:OTUB1) increases p(HGNC:MAPT) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) + p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) + p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) + p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) + p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) + p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(UbK48)) - pmid:25036637 + pmid:28083634 - a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) + p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(UbK63)) @@ -89671,49 +90294,63 @@

Statements

- pmid:25036637 + pmid:22908190 - p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) + p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pmid:24027553 - p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) + p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:25036637 + pmid:14612456 - p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) + p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2) + + + pmid:14612456 + + p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + pmid:8391280 + + p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) + + - pmid:25036637 + pmid:25378699 - p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + p(HGNC:MAPT, pmod(Ub)) positiveCorrelation deg(p(HGNC:MAPT)) - pmid:25036637 + pmid:24905733 - p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) + p(HGNC:MAPT, pmod(Ub)) negativeCorrelation act(p(HGNC:MAPT)) @@ -89724,75 +90361,46 @@

Statements

- pmid:29311797 + pmid:28083634 - p(HGNC:FKBP4) isA a(MESH:Immunophilins) + complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:29311797 + pmid:28083634 - p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") + complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(HBP:"Tau aggregates") - pmid:26631930 + pmid:28083634 - p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") + p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(Ub)) - - - pmid:26903089 + pmid:28083634 - act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") + p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5)) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + pmid:28083634 + + p(HGNC:USP5) causesNoChange a(HBP:"Tau aggregates") + @@ -89800,15 +90408,30 @@

Statements

- + + + pmid:28083634 + + p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(Ub)) + - + + + pmid:28083634 + + p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X)) + - + + + pmid:28083634 + + p(HGNC:USP9X) causesNoChange a(HBP:"Tau aggregates") + @@ -89818,143 +90441,112 @@

Statements

- pmid:21882945 + pmid:28083634 - p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(UbK48)) - pmid:21882945 + pmid:28083634 - p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) - pmid:21882945 + pmid:28083634 - p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:21882945 + pmid:28083634 - p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") + p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(UbK48)) - pmid:21882945 + pmid:28083634 - p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) + p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - - - - - - - pmid:25036637 + pmid:28083634 - p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) + p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) + p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - - - - - pmid:25036637 + pmid:28083634 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(MGI:Otub1) increases p(MGI:Mapt) - pmid:25036637 + pmid:28083634 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(MGI:Otub1) increases a(HBP:"Tau oligomers") - pmid:25036637 + pmid:28083634 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) + p(MGI:Otub1) increases a(HBP:"Tau oligomers") - - - - - - - - - - - - - - - pmid:25036637 + pmid:28083634 - p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) + p(MGI:Otub1) increases a(HBP:"Tau oligomers") - - - pmid:25036637 - - p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) - - @@ -89967,9 +90559,9 @@

Statements

- pmid:25036637 + pmid:29024336 - p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) + p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") @@ -89990,73 +90582,84 @@

Statements

- - - - - + + + pmid:29202785 + + p(MGI:Mapt) increases bp(GO:"neuron migration") + - + + + pmid:29202785 + + p(MGI:Mapt) increases bp(GO:"neuron differentiation") + - pmid:25036637 + pmid:29202785 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + p(MGI:Mapt) increases bp(GO:"neuron maturation") - pmid:25036637 + pmid:30126037 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) + p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") - pmid:25036637 + pmid:30126037 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) + p(MGI:Mapt) increases bp(HP:Neurodegeneration) - pmid:25036637 + pmid:30126037 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) + p(MGI:Mapt) increases p(MGI:Cdkn2a) - pmid:25036637 + pmid:30126037 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) + p(MGI:Mapt) increases bp(GO:"cellular senescence") - pmid:25036637 + pmid:30126037 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) + p(MGI:Mapt) increases path(HP:"Brain atrophy") - + + + pmid:28408124 + + tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates") + @@ -90074,7 +90677,12 @@

Statements

- + + + pmid:18096814 + + p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + @@ -90090,27 +90698,52 @@

Statements

- + + + pmid:26400044 + + p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + - + + + pmid:25995053 + + p(MGI:Mapt) association p(MGI:Dapk1) + - + + + pmid:25995053 + + p(MGI:Mapt) partOf complex(p(MGI:Dapk1), p(MGI:Mapt)) + - + + + pmid:29221819 + + p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) + - + + + pmid:28877763 + + p(MGI:Mapt) positiveCorrelation p(MGI:Syk) + @@ -90123,13 +90756,6 @@

Statements

- - - - pmid:21882945 - - complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) - @@ -90137,22 +90763,8 @@

Statements

- - - pmid:21882945 - - complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) - - - - - pmid:25374103 - - complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) - - @@ -90171,294 +90783,198 @@

Statements

- pmid:25036637 + pmid:28083634 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) + p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:28083634 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) + p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(HBP:"Tau oligomers") - pmid:25036637 + pmid:28083634 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) + p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:25036637 + pmid:25437566 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) + act(p(FPLX:HSP90)) association a(CHEBI:ATP) - pmid:25036637 + pmid:25437566 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) + p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:25036637 + pmid:25437566 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) + p(FPLX:HSP90) increases bp(GO:"protein folding") - pmid:25036637 + pmid:23746257 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) + act(p(FPLX:HSP90)) increases bp(GO:"protein folding") - pmid:25036637 + pmid:25784053 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) + p(FPLX:HSP90) regulates bp(GO:"protein folding") - pmid:25036637 + pmid:29311797 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) + act(p(FPLX:HSP90)) increases bp(GO:"protein folding") - pmid:25036637 + pmid:27491084 - p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) + p(FPLX:HSP90) association bp(HBP:Proteostasis) - pmid:25036637 + pmid:29311797 - p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) + p(FPLX:HSP90) association bp(HBP:Proteostasis) - pmid:25036637 + pmid:23746257 - p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) + act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") - pmid:25036637 + pmid:23746257 - p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) + act(p(FPLX:HSP90)) association bp(GO:"protein refolding") - pmid:25036637 + pmid:23746257 - p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) + p(FPLX:HSP90) association bp(GO:"cell cycle") - pmid:25036637 + pmid:23746257 - p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) + p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25036637 + pmid:23746257 - p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") - - - - - pmid:25036637 + pmid:23746257 - a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) + p(FPLX:HSP90) association bp(GO:"protein transport") - pmid:25036637 + pmid:23746257 - a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) + p(FPLX:HSP90) association bp(GO:"protein secretion") - - - - - pmid:21882945 + pmid:23746257 - p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) + p(FPLX:HSP90) association bp(GO:"immune response") - pmid:29311797 + pmid:23746257 - act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) + p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") - pmid:26631930 + pmid:25784053 - p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") - - - - - pmid:21882945 + pmid:25784053 - p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + p(FPLX:HSP90) regulates bp(MESH:Proteolysis) @@ -90467,25 +90983,25 @@

Statements

pmid:29311797 - p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + act(p(FPLX:HSP90)) increases bp(MESH:Proteolysis) - pmid:29311797 + pmid:25784053 - p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") + act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) - pmid:29311797 + pmid:24563850 - p(HGNC:PTGES3) increases p(HGNC:MAPT) + p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") @@ -90494,7 +91010,7 @@

Statements

pmid:29311797 - p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph)) + act(p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") @@ -90503,195 +91019,187 @@

Statements

pmid:29311797 - p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") + p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") - pmid:25036637 + pmid:21882945 - p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") + act(p(FPLX:HSP90)) association a(CHEBI:celastrol) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) + p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:25036637 + pmid:21882945 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") - pmid:25036637 + pmid:21882945 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + p(FPLX:HSP90) increases bp(GO:autophagy) - - - - - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) + p(FPLX:HSP90) increases act(p(HGNC:STUB1)) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) + p(FPLX:HSP90) increases bp(GO:"protein catabolic process") - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) + p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph)) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph)) - - - - - - - - - - - - - pmid:25036637 + pmid:19363271 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) + p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) + p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) - pmid:25036637 + pmid:21882945 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) - pmid:25036637 + pmid:29311797 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) - - - - - - - - - - - - - + + + pmid:25374103 + + p(FPLX:HSP90) regulates deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + - + + + pmid:29311797 + + p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + - + + + pmid:25374103 + + p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + - pmid:25036637 + pmid:29311797 - p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + act(p(FPLX:HSP90)) increases bp(GO:"protein modification process") - + + + pmid:29311797 + + p(FPLX:HSP90) regulates a(HBP:"Tau aggregates") + - pmid:25036637 + pmid:29311797 - p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) + p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) - pmid:25036637 + pmid:29311797 - p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) + p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") @@ -90706,2388 +91214,2394 @@

Statements

- pmid:25036637 + pmid:29311797 - a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") + act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) - pmid:24706768 + pmid:19363271 - a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) + p(FPLX:HSP90) association p(HBP:"VQIVYK motif") - pmid:24706768 + pmid:19363271 - a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis) + p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) - pmid:24706768 + pmid:19363271 - a(HBP:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") - pmid:24706768 + pmid:20133804 - p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") + p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) - - - - - pmid:24706768 + pmid:21367866 - complex(a(HBP:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") + act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) - pmid:28803412 + pmid:21367866 - p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") + act(p(FPLX:HSP90)) negativeCorrelation deg(p(HGNC:MAPT)) - pmid:28803412 + pmid:25437566 - p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") + act(p(FPLX:HSPA)) association a(CHEBI:ATP) - pmid:28803412 + pmid:27491084 - p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") + p(FPLX:HSPA) association bp(HBP:Proteostasis) - pmid:28803412 + pmid:27491084 - p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") + p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates") - pmid:28803412 + pmid:27491084 - a(HBP:HBP00016) increases path(MESH:"Parkinson Disease") + p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:27075649 + pmid:24563850 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease") + p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:27075649 + pmid:27491084 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy") + p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") - pmid:27075649 + pmid:23746257 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease") + act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") - pmid:30116051 + pmid:23746257 - a(HBP:HBP00016) decreases complex(GO:"proteasome complex") + act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") - pmid:28803412 + pmid:24563850 - a(HBP:HBP00093) increases path(MESH:"Parkinson Disease") + p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") - pmid:28803412 + pmid:27491084 - a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease") + p(FPLX:HSPA) decreases bp(HBP:misfolding) - pmid:28803412 + pmid:24563850 - a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease") + p(FPLX:HSPA) decreases bp(HBP:misfolding) - pmid:28803412 + pmid:27491084 - a(HBP:HBP00093) increases a(HBP:HBP00092) + p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") - pmid:27075649 + pmid:27491084 - a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) + p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") - pmid:28803412 + pmid:27491084 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(FPLX:HSPA) decreases path(HBP:proteotoxicity) - pmid:28803412 + pmid:27491084 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(FPLX:HSPA) decreases path(HBP:proteotoxicity) - pmid:27075649 + pmid:27491084 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) decreases a(MESH:Mitochondria) + p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") - pmid:28803412 + pmid:14556719 - a(HBP:HBP00093) increases bp(HBP:HBP00037) + p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) - pmid:28803412 + pmid:14556719 - a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress") + p(FPLX:HSPA) increases a(HBP:"protein aggregates") - pmid:28803412 + pmid:14556719 - a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex")) + p(FPLX:HSPA) increases bp(GO:"cell death") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) increases bp(GO:"microglial cell activation") + act(p(FPLX:HSPA)) association bp(GO:"protein refolding") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) increases bp(GO:"inflammatory response") + act(p(FPLX:HSPA)) association bp(GO:"protein refolding") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) increases act(p(HGNC:TLR2)) + act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species") + act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") + p(FPLX:HSPA) decreases a(HBP:"huntingtin aggregates") - pmid:28803412 + pmid:25784053 - a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") - pmid:27075649 + pmid:25784053 - a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)") + p(FPLX:HSPA) regulates bp(GO:"protein folding") - pmid:28803412 + pmid:24563850 - a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport") + p(FPLX:HSPA) increases bp(GO:"protein folding") - pmid:28803412 + pmid:25784053 - a(HBP:HBP00093) decreases bp(GO:"axonal transport") + p(FPLX:HSPA) regulates bp(MESH:Proteolysis) - pmid:28803412 + pmid:25784053 - a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") - pmid:28803412 + pmid:29626319 - a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus") + p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta")) - pmid:28803412 + pmid:25437566 - a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") + act(p(HGNC:HSPD1)) association a(CHEBI:ATP) - pmid:27075649 + pmid:27491084 - a(HBP:HBP00092) increases bp(GO:"apoptotic process") + p(HGNC:HSPD1) association bp(HBP:Proteostasis) - pmid:28803412 + pmid:25784053 - a(HBP:HBP00092) increases bp(GO:"inflammatory response") + p(HGNC:HSPD1) increases bp(HBP:Proteostasis) - pmid:28803412 + pmid:23746257 - a(HBP:HBP00092) increases bp(GO:"microglial cell activation") + p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") - pmid:27075649 + pmid:25784053 - a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") + p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") - pmid:27075649 + pmid:25784053 - a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) + p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") - pmid:27075649 + pmid:27491084 - a(HBP:HBP00092) increases a(HBP:HBP00016) + p(HGNC:TPR) association bp(HBP:Proteostasis) - pmid:28803412 + pmid:27491084 - p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(HBP:Proteostasis) - - - - - pmid:24113872 + pmid:27491084 - p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) - pmid:24113872 + pmid:23746257 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) - pmid:24113872 + pmid:23746257 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"huntingtin aggregates") - pmid:24113872 + pmid:23746257 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"alpha-synuclein aggregates") - pmid:24113872 + pmid:25784053 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") - pmid:24113872 + pmid:27491084 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") + p(FPLX:HSPB) association bp(HBP:Proteostasis) - pmid:30126037 + pmid:27491084 - act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") + p(FPLX:HSPB) association bp(HBP:misfolding) - pmid:28803412 + pmid:23746257 - a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") + act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") - pmid:28803412 + pmid:25784053 - a(CHEBI:salubrinal) decreases a(HBP:HBP00093) + p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") - pmid:21339331 + pmid:25437566 - a(MESH:"Cell Membrane") association p(HGNC:ANXA2) + p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21339331 + pmid:25437566 - a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + p(HGNC:HSPA8) increases bp(GO:"protein folding") - - - - - pmid:28803412 + pmid:25437566 - complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") + p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates") - - - - - pmid:26631930 + pmid:29758300 - act(a(MESH:Kinesin)) association p(HGNC:MAPT) + p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) - pmid:28803412 + pmid:21882945 - p(HGNC:USP19) increases sec(p(HGNC:SNCA)) + act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT)) - pmid:28803412 + pmid:18930136 - a(CHEBI:curcumin) decreases a(HBP:HBP00092) + p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) - pmid:28803412 + pmid:18930136 - a(CHEBI:curcumin) decreases a(HBP:HBP00016) + p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) - pmid:30116051 + pmid:24706768 - a(CHEBI:curcumin) decreases a(HBP:HBP00016) + p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") - pmid:28803412 + pmid:24706768 - a(CHEBI:curcumin) decreases a(HBP:HBP00018) + p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") - pmid:30116051 + pmid:24706768 - a(CHEBI:curcumin) increases bp(GO:macroautophagy) + p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") - pmid:30116051 + pmid:21882945 - a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) + p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:30116051 + pmid:18500754 - a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) + p(HGNC:HSPA8) association p(HBP:"microtubule-binding region") - pmid:30116051 + pmid:18500754 - a(CHEBI:curcumin) decreases a(HBP:HBP00022) + act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) - pmid:30116051 + pmid:25437566 - a(CHEBI:curcumin) decreases a(HBP:HBP00009) + p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:28803412 + pmid:25437566 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) + p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates") - pmid:28803412 + pmid:23746257 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) + p(FPLX:"CCT_complex") decreases a(HBP:"huntingtin aggregates") - pmid:28803412 + pmid:25784053 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) + p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") - pmid:29626319 + pmid:25784053 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) + p(FPLX:"CCT_complex") association bp(GO:"cell division") - pmid:29626319 + pmid:25784053 - a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) + p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") - pmid:29626319 + pmid:25784053 - a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) + p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) - pmid:28775333 + pmid:25437566 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) + p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:28775333 + pmid:25437566 - a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") + p(HGNC:DNAJA1) increases bp(GO:"protein folding") - pmid:28775333 + pmid:25437566 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) + p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates") - pmid:28775333 + pmid:25437566 - a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) + p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:28803412 + pmid:23746257 - a(HBP:HBP00094) decreases a(HBP:HBP00016) + p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:28803412 + pmid:25036637 - a(HBP:HBP00094) decreases bp(GO:"apoptotic process") + p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:27075649 + pmid:29311797 - path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016) + p(HGNC:STIP1) decreases p(HGNC:MAPT) - pmid:27075649 + pmid:29311797 - a(HBP:HBP00095) increases bp(GO:"neuron death") + p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") - pmid:27075649 + pmid:25784053 - a(HBP:HBP00095) decreases bp(GO:"ion homeostasis") + bp(GO:"protein folding") association bp(HBP:Proteostasis) - pmid:27075649 + pmid:29311797 - a(HBP:HBP00095) increases a(HBP:HBP00016) + bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") - pmid:27075649 + pmid:25437566 - a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093) + p(HGNC:TTC1) increases bp(GO:"protein folding") - pmid:29807032 + pmid:24706768 - act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") + a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:29807032 + pmid:24706768 - p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) + a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:29807032 + pmid:25437566 - path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein") + p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates") - pmid:23211705 + pmid:25437566 - p(MGI:Crh) decreases a(MESH:Estradiol) + p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates") - pmid:23211705 + pmid:25437566 - p(MGI:Crh) regulates p(HGNC:CGB3) + p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates") - pmid:23211705 + pmid:25437566 - p(MGI:Crh) decreases p(HGNC:CGB3) + p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates") - pmid:23211705 + pmid:25437566 - p(MGI:Crh) causesNoChange a(MESH:Progesterone) + p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates") - pmid:23211705 + pmid:25036637 - p(MGI:Crh) decreases a(MESH:Progesterone) + p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) - pmid:23211705 + pmid:29311797 - p(MGI:Crh) decreases a(MESH:Progesterone) + p(HGNC:HSP90AB1) association bp(GO:"embryo development") - pmid:25125464 + pmid:29311797 - p(MGI:Crh) increases p(HBP:"Tau epitope, AT8") + p(HGNC:HSP90AB1) association bp(GO:"cell maturation") - pmid:25125464 + pmid:29311797 - p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1") + p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") - pmid:25125464 + pmid:29311797 - p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) + p(HGNC:HSP90AB1) association bp(GO:"signal transduction") - pmid:25125464 + pmid:29311797 - p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422)) + p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") - pmid:8940412 + pmid:27491084 - act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") + a(MESH:"Molecular Chaperones") decreases path(HBP:proteotoxicity) - pmid:8940412 + pmid:23746257 - act(p(RGD:Crh)) regulates sec(p(RGD:Pomc)) + a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") - pmid:8940412 + pmid:25784053 - act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) + a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") - pmid:8940412 + pmid:21882945 - a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) + a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:8940412 + pmid:29311797 - a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) + a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") - pmid:8940412 + pmid:29311797 - a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") + a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) - pmid:8940412 + pmid:27491084 - a(CHEBI:antalarmin) decreases sec(p(RGD:Pomc)) + bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:30145931 + pmid:27491084 - a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) + bp(HBP:Proteostasis) association p(HGNC:HSPD1) - pmid:30145931 + pmid:27491084 - a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + bp(HBP:Proteostasis) association p(FPLX:HSPA) - pmid:23528736 + pmid:27491084 - a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + bp(HBP:Proteostasis) association p(HGNC:TPR) - pmid:30145931 + pmid:27491084 - a(CHEBI:epoxomicin) increases bp(GO:"protein ubiquitination") + bp(HBP:Proteostasis) association p(FPLX:HSPB) - pmid:30145931 + pmid:27491084 - a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + bp(HBP:Proteostasis) association p(FPLX:HSP90) - pmid:30145931 + pmid:29311797 - a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + bp(HBP:Proteostasis) association p(FPLX:HSP90) - pmid:30145931 + pmid:27491084 - a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") - pmid:30145931 + pmid:23746257 - a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(HBP:Proteostasis) association bp(GO:"inflammatory response") - pmid:30145931 + pmid:23746257 - a(CHEBI:epoxomicin) decreases a(MESH:"Dendritic Spines") + bp(HBP:Proteostasis) association bp(GO:"response to oxidative stress") - pmid:24027553 + pmid:23746257 - a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) + bp(HBP:Proteostasis) association bp(GO:"behavioral response to starvation") - pmid:24027553 + pmid:23746257 - a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + bp(HBP:Proteostasis) negativeCorrelation bp(GO:"cell death") - pmid:24027553 + pmid:25784053 - a(CHEBI:epoxomicin) increases p(HGNC:MAPT) + bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis") - pmid:23528736 + pmid:25784053 - a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + bp(HBP:Proteostasis) association bp(GO:"protein folding") - pmid:30145931 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") - pmid:30145931 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) + bp(HBP:Proteostasis) association bp(MESH:Proteolysis) - pmid:30145931 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) + bp(HBP:Proteostasis) decreases bp(MESH:Aging) - pmid:29215007 + pmid:21882945 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + bp(HBP:Proteostasis) regulates p(HGNC:MAPT) - pmid:29215007 + pmid:21882945 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly") + bp(HBP:Proteostasis) regulates a(MESH:Proteins) - pmid:26751493 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"AAA ATPases") association bp(HBP:Proteostasis) - pmid:17493042 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) - pmid:17493042 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") + p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) - pmid:21367866 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37) + p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) - pmid:22156579 + pmid:23528736 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) + p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") - - - pmid:22156579 - - p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf a(HBP:"Tau epitope, 12E8") - + - pmid:22833681 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) + + - pmid:30145931 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) + + - pmid:28784767 + pmid:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:AR) association a(PUBCHEM:5833) - pmid:18239272 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) - pmid:29191965 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") - pmid:22817713 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates") + p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") - pmid:22817713 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers") + p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") - pmid:22486774 + pmid:18930136 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers") + p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") - pmid:14612456 + pmid:18930136 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) - pmid:20071522 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph)) + p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") - pmid:20071522 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") + + - pmid:20071522 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5) + p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21367866 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37) + p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") - pmid:17078951 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA) + p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") - pmid:17078951 + pmid:28803412 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 202))) + p(HGNC:SNCA) association path(MESH:"Parkinson Disease") + + - pmid:25331948 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo a(HBP:"Tau epitope, CP13") + p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") + + + + + + - pmid:26118667 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) negativeCorrelation m(MIRBASE:"rno-mir-195") + p(HGNC:SNCA) association p(HGNC:SNCAIP) + + - pmid:19459590 + pmid:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13") + p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) - pmid:22833681 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") - pmid:24406748 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") - pmid:23294633 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization") - pmid:22002427 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + p(HGNC:SNCA) increases bp(GO:"apoptotic process") + + - pmid:22002427 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(GO:"neurofibrillary tangle") + act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub)) - pmid:22253473 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle") + act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub)) - pmid:16464864 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation a(CHEBI:"okadaic acid") + act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") - pmid:16464864 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") - pmid:30145931 + pmid:22908190 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) - pmid:28784767 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:SNCA) decreases bp(GO:autophagy) - pmid:18239272 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:SNCA) decreases p(HGNC:RAB1A) + + + + + + + + + + - pmid:24760868 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) + path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis) - pmid:29191965 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") - pmid:22817713 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates") + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) - pmid:22817713 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers") + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) - pmid:22486774 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers") + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) - pmid:14612456 + pmid:24706768 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) - pmid:17078951 + pmid:24706768 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA) + path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:26118667 + pmid:27574109 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) negativeCorrelation m(MIRBASE:"rno-mir-195") + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") - pmid:22833681 + pmid:27574109 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") - pmid:24406748 + pmid:27574109 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") - pmid:23294633 + pmid:27574109 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") - pmid:22253473 + pmid:27574109 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle") + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") - pmid:30145931 + pmid:27491084 - a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) + p(HGNC:STUB1) decreases path(HP:Neurodegeneration) - pmid:30145931 + pmid:22908190 - a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) - pmid:29626319 + pmid:25036637 - a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) + p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:29626319 + pmid:25036637 - a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") + p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) - pmid:26692334 + pmid:25036637 - a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) + p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1)) - pmid:26692334 + pmid:25374103 - a(CHEBI:rolipram) positiveCorrelation act(p(FPLX:PKA)) + p(HGNC:STUB1) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) - pmid:26692334 + pmid:25036637 - a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) + p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") - pmid:26692334 + pmid:24027553 - a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates") + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(Ub)) - pmid:30145931 + pmid:23528736 - a(CHEBI:cycloheximide) decreases bp(GO:translation) + p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") - pmid:30145931 + pmid:21882945 - a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") - pmid:23702978 + pmid:21882945 - a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") - pmid:30145931 + pmid:25374103 - a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) + p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:30145931 + pmid:25374103 - a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:STUB1) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:STUB1) negativeCorrelation p(HBP:"Tau C3") - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:STUB1) causesNoChange bp(GO:"cell death") - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) association a(GO:microtubule) + p(HGNC:STUB1) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) association a(HBP:HBP00006) + p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(Ub)), p(HGNC:STUB1)) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + p(HGNC:STUB1) increases deg(p(HBP:"4R tau", var("p.Lys280del"))) - pmid:8282104 + pmid:25374103 - p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) negativeCorrelation act(p(FPLX:Caspase)) - pmid:26458742 + pmid:25374103 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) - pmid:20071522 + pmid:25374103 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph)) + p(HGNC:STUB1) increases complex(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) - pmid:20071522 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(HGNC:STUB1) association path(MESH:"Huntington Disease") - pmid:20071522 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5) + p(HGNC:STUB1) association path(MESH:"Parkinson Disease") - pmid:21367866 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37) + p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") - pmid:17078951 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA) + p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") - pmid:25331948 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:STUB1) association path(MESH:Neoplasms) - pmid:19459590 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:22072628 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:misfolding))) - pmid:26996941 + pmid:26631930 - p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1)) + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) - pmid:28420982 + pmid:14612456 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) - pmid:26458742 + pmid:17954934 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) - pmid:28420982 + pmid:25031639 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + act(p(HGNC:STUB1)) negativeCorrelation a(HBP:"Tau epitope, 12E8") - pmid:14612456 + pmid:25031639 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) - pmid:20071522 + pmid:27325702 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph)) + p(HGNC:STUB1) association p(HBP:"APP, ACR") - pmid:20071522 + pmid:27325702 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") - pmid:20071522 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5) + p(UNIPROT:P15705) decreases path(HBP:proteotoxicity) - pmid:21367866 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37) + p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) - pmid:17078951 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA) + p(UNIPROT:P32589) decreases path(HBP:proteotoxicity) - pmid:17078951 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 396))) + p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:22156579 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(HBP:"Tau epitope, PHF1") + p(HGNC:HSPB7) decreases path(HBP:proteotoxicity) - pmid:23948915 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") + p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") - pmid:28176663 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") + p(UNIPROT:Q9XXG5) decreases path(HBP:proteotoxicity) - pmid:22833681 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") - pmid:29844403 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation act(p(HGNC:GSK3B)) + p(UNIPROT:P12612) decreases path(HBP:proteotoxicity) - pmid:24760868 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) + p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") - pmid:26458742 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(UNIPROT:P02829) decreases path(HBP:proteotoxicity) - pmid:14612456 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph)) + p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") - pmid:21367866 + pmid:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37) + bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) - pmid:17078951 + pmid:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA) + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) - pmid:17078951 + pmid:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Ser, 404))) + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) - pmid:11943212 + pmid:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2") + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) - pmid:22156579 + pmid:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation a(HBP:"Tau epitope, PHF1") + bp(HBP:misfolding) association p(FPLX:HSPB) - - - - - - - - - - - - - - - - - - - pmid:8282104 + pmid:24563850 - a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph)) + bp(HBP:misfolding) increases path(MESH:"Protein Aggregation, Pathological") - + + + pmid:29758300 + + a(HBP:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") + - pmid:8282104 + pmid:29758300 - complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph)) + a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:8282104 + pmid:14556719 - a(HBP:HBP00006) association p(HGNC:CDK5) + a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") - pmid:8282104 + pmid:14556719 - a(HBP:HBP00006) association p(HGNC:PRKACA) + a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") - pmid:8282104 + pmid:14556719 - a(HBP:HBP00006) association p(FPLX:ERK) + a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:8282104 + pmid:27491084 - a(HBP:HBP00006) association p(FPLX:GSK3) + p(HGNC:HSPB1) association a(HBP:"amyloid-beta aggregates") - pmid:30116051 + pmid:21882945 - a(HBP:HBP00006) decreases act(complex(GO:"proteasome complex")) + p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:30116051 + pmid:21882945 - a(HBP:HBP00006) decreases bp(GO:"chaperone-mediated autophagy") + p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") - pmid:26458742 + pmid:21882945 - a(HBP:HBP00006) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) + p(HGNC:HSPB1) increases bp(GO:autophagy) - pmid:26458742 + pmid:21882945 - a(HBP:HBP00006) causesNoChange bp(GO:"cell death") + p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - + + + pmid:21882945 + + p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + - pmid:27594586 + pmid:14963027 - g(DBSNP:rs63751011) increases p(HGNC:MAP2) + p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) - pmid:27594586 + pmid:21882945 - g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + p(HGNC:HSPB1) increases p(HGNC:MAPT) - pmid:27594586 + pmid:21882945 - g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) + p(HGNC:HSPB1) decreases p(HGNC:MAPT) - pmid:27594586 + pmid:14963027 - g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) + p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) - pmid:27594586 + pmid:21882945 - g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) + p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) - pmid:27594586 + pmid:21882945 - g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") + p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:27594586 + pmid:14963027 - g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") + p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) - pmid:27594586 + pmid:14963027 - g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) + p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) - pmid:27594586 + pmid:14963027 - g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9)) + p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") - pmid:27594586 + pmid:27491084 - g(DBSNP:rs63751011) increases r(HGNC:MMP9) + p(HGNC:CRYAB) association a(HBP:"amyloid-beta aggregates") - pmid:27594586 + pmid:27491084 - g(DBSNP:rs63751011) increases r(HGNC:MMP9) + p(HGNC:HSPB6) association a(HBP:"amyloid-beta aggregates") - pmid:27594586 + pmid:27491084 - g(DBSNP:rs63751011) increases r(HGNC:MMP2) + p(HGNC:HSF1) increases bp(HBP:Proteostasis) - pmid:27594586 + pmid:21882945 - g(DBSNP:rs63751011) increases r(HGNC:MMP2) + p(HGNC:HSF1) increases bp(HBP:Proteostasis) - pmid:27594586 + pmid:23746257 - g(DBSNP:rs63751011) increases bp(GO:"neuron death") + p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") - pmid:27594586 + pmid:23746257 - g(DBSNP:rs63751011) increases a(HBP:HBP00045) + p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") - pmid:27594586 + pmid:25784053 - g(DBSNP:rs63751011) decreases a(HBP:HBP00044) + act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones") - - - + + + pmid:23746257 + + p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") + - pmid:27594586 + pmid:25784053 - path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) + act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + + - pmid:27594586 + pmid:25784053 - a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") + act(p(HGNC:HSF1)) association path(MESH:Neoplasms) - pmid:8726973 + pmid:24563850 - a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) + p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") - pmid:23666762 + pmid:21882945 - a(CHEBI:staurosporine) decreases act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) + p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + + - pmid:23001711 + pmid:30116051 - a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin)) + act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA)) - pmid:23001711 + pmid:27491084 - a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) - pmid:27594586 + pmid:27491084 - a(CHEBI:rotenone) increases bp(HBP:HBP00037) + a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) @@ -93098,269 +93612,274 @@

Statements

- pmid:27594586 + pmid:25784053 - composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") - + + + pmid:22817713 + + p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates") + - pmid:27594586 + pmid:22817713 - composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates")) + + + + - pmid:27594586 + pmid:25784053 - p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) + p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:27594586 + pmid:29758300 - p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24686445 + pmid:29758300 - p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:29758300 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:29758300 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:25784053 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27594586 + pmid:29758300 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) + bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) - pmid:27594586 + pmid:29758300 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) + bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + bp(GO:macroautophagy) negativeCorrelation a(CHEBI:"amyloid-beta") - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + bp(GO:macroautophagy) increases deg(a(CHEBI:"amyloid-beta")) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) + bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) + bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") + bp(GO:macroautophagy) association p(HGNC:BECN1) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") - pmid:27594586 + pmid:29758300 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + bp(GO:macroautophagy) increases deg(a(HBP:"Tau aggregates")) - - - pmid:27594586 + pmid:29758300 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) + bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) - pmid:27594586 + pmid:29758300 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") - pmid:27594586 + pmid:29758300 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") - - - pmid:30116051 + pmid:29758300 - p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:30116051 + pmid:29758300 - p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - pmid:30116051 + pmid:29758300 - p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1)) + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") - pmid:30116051 + pmid:22908190 - p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1)) + bp(GO:macroautophagy) increases a(GO:autophagosome) - pmid:30116051 + pmid:22908190 - p(HGNC:FOXO1) increases bp(GO:macroautophagy) + bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) - pmid:30116051 + pmid:18930136 - p(HGNC:FOXO3) increases bp(GO:macroautophagy) + bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") - pmid:30116051 + pmid:18930136 - p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) + bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) @@ -93369,451 +93888,445 @@

Statements

pmid:30116051 - p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1)) + bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(HBP:HBP00007))) - - - pmid:30116051 + pmid:29024336 - act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") + bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) - pmid:30116051 + pmid:29024336 - p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1)) + bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) - pmid:30116051 + pmid:29024336 - p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) + bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:30116051 + pmid:29024336 - act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) + bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:30116051 + pmid:29024336 - p(HGNC:MAPT, pmod(HBP:HBP00007)) decreases deg(p(HGNC:MAPT)) + bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:30116051 + pmid:29024336 - p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") + bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) - pmid:30116051 + pmid:26751493 - p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) + bp(GO:macroautophagy) decreases p(HGNC:MAPT) + + - pmid:30116051 + pmid:22908190 - p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") + a(GO:autophagosome) association a(HBP:"dystrophic neurite") - pmid:30116051 + pmid:22908190 - p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:18930136 - p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:18930136 - p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:22908190 - p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(GO:autophagosome) increases a(GO:organelle) - pmid:30116051 + pmid:22908190 - p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") + a(GO:autophagosome) association p(HGNC:APP) - pmid:30116051 + pmid:18930136 - p(HGNC:GBA, var("?")) decreases bp(GO:autophagy) + a(GO:autophagosome) increases bp(GO:autophagy) - pmid:30116051 + pmid:18930136 - p(HGNC:GBA, var("?")) increases a(HBP:HBP00016) + a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") - pmid:30116051 + pmid:18930136 - p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") + a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) - - - pmid:30116051 + pmid:18930136 - p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") + a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) - - - pmid:30116051 + pmid:18930136 - p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:30116051 + pmid:18930136 - p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") - - - pmid:30116051 + pmid:18930136 - p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) - - - pmid:30116051 + pmid:18930136 - p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") + a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) - pmid:30116051 + pmid:22908190 - p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") + a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments") - pmid:30116051 + pmid:22908190 - p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) + a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin) - pmid:30116051 + pmid:22908190 - a(CHEBI:clonidine) increases bp(GO:autophagy) + a(HBP:"dystrophic neurite") association a(GO:autophagosome) - pmid:30116051 + pmid:22908190 - a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) + a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:29758300 - a(CHEBI:Rilmenidine) increases bp(GO:autophagy) + a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:18930136 - a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) + a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") - pmid:30116051 + pmid:18930136 - p(HGNC:CAPN2) decreases bp(GO:autophagy) + a(GO:autolysosome) decreases path(HBP:Neurodegeneration) - pmid:30116051 + pmid:29758300 - p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) + bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) - pmid:24027553 + pmid:29758300 - p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles") + bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:29758300 - p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) + bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) increases bp(GO:autophagy) + bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) increases deg(p(HGNC:MAPT)) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) increases deg(p(HGNC:SNCA)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) - pmid:30116051 + pmid:22908190 - p(HGNC:CAST) increases deg(p(HGNC:SOD1)) + bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) - pmid:30116051 + pmid:22908190 - a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) + bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) - pmid:30116051 + pmid:22908190 - a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) + bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) - pmid:30116051 + pmid:22908190 - a(CHEBI:Calpeptin) increases bp(GO:autophagy) + bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) - pmid:30116051 + pmid:22908190 - a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) + bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(Ub)) - pmid:30116051 + pmid:22908190 - a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) + bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) - pmid:30116051 + pmid:22908190 - a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) + bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) - pmid:30116051 + pmid:22908190 - a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) + bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) - pmid:30116051 + pmid:22908190 - a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:"amyloid-beta") - pmid:30116051 + pmid:22908190 - a(CHEBI:selenomethionine) increases bp(GO:autophagy) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) - pmid:30116051 + pmid:22908190 - a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) + + - pmid:30116051 + pmid:29758300 - a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") + p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") @@ -93822,445 +94335,440 @@

Statements

pmid:30116051 - a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") + p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) - pmid:30116051 + pmid:29758300 - p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) + bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) - - - - - pmid:30116051 + pmid:22908190 - composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) + a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(Ub))) - pmid:30116051 + pmid:22908190 - a(CHEBI:metformin) increases act(p(FPLX:AMPK)) + a(GO:lysosome) increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:22908190 - a(CHEBI:metformin) increases bp(GO:autophagy) + a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:22908190 - a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta") + act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:22908190 - a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) + a(GO:lysosome) increases a(GO:organelle) - pmid:30116051 + pmid:18930136 - a(CHEBI:metformin) decreases bp(GO:"neuron death") + a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) - pmid:23528736 + pmid:18930136 - p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates") + act(a(GO:lysosome)) decreases path(HBP:Neurodegeneration) - pmid:30116051 + pmid:18930136 - a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) + act(a(GO:lysosome)) increases a(GO:autophagosome) - pmid:30116051 + pmid:18930136 - a(CHEBI:calcitriol) increases bp(GO:autophagy) + act(a(GO:lysosome)) increases a(GO:lysosome) - pmid:29626319 + pmid:18930136 - a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") - pmid:29626319 + pmid:29024336 - a(CHEBI:calcitriol) decreases p(HGNC:AGER) + a(GO:lysosome) increases deg(a(HBP:HBP00053)) - pmid:29626319 + pmid:29590627 - a(CHEBI:calcitriol) increases p(HGNC:LRP1) + a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) - - - - - pmid:30116051 + pmid:29590627 - complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) + a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:26631930 + pmid:29590627 - p(HGNC:FUS) decreases p(HBP:"4R tau") + a(GO:lysosome) association a(HBP:"Tau aggregates") - pmid:26631930 + pmid:29590627 - p(HGNC:FUS) decreases p(HBP:"Tau isoform F (441 aa)") + a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:26631930 + pmid:24561250 - p(HGNC:FUS) decreases p(HBP:"Tau isoform C (410 aa)") + a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:26631930 + pmid:29758300 - p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") + p(MESH:Proteins, pmod(HBP:misfolding)) decreases bp(GO:"neuron cellular homeostasis") - pmid:30116051 + pmid:29758300 - a(CHEBI:fisetin) increases bp(GO:macroautophagy) + p(MESH:Proteins, pmod(HBP:misfolding)) decreases a(MESH:Neurons) - pmid:30116051 + pmid:14556719 - a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) + p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") - pmid:30116051 + pmid:24457024 - a(CHEBI:fisetin) decreases a(HBP:HBP00018) + p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") - pmid:30116051 + pmid:18930136 - p(HGNC:ABL1) decreases bp(GO:macroautophagy) + p(MESH:Proteins, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:29191965 + pmid:18930136 - p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1) - pmid:26631930 + pmid:29758300 - p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) - pmid:17493042 + pmid:18930136 - p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) - pmid:23687953 + pmid:29758300 - act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) - pmid:30116051 + pmid:29758300 - a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") - pmid:30116051 + pmid:23528736 - a(CHEBI:nilotinib) increases bp(GO:macroautophagy) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") - pmid:30116051 + pmid:29758300 - a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:18930136 - a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:18930136 - a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases bp(GO:macroautophagy) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases p(HGNC:BECN1) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases p(HGNC:ATG5) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases p(HGNC:MAP1LC3A) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) decreases p(FPLX:mTORC1) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases p(HGNC:CTSB) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) increases bp(GO:cognition) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) - pmid:30116051 + pmid:14556719 - a(CHEBI:cilostazol) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) - pmid:30116051 + pmid:14556719 - a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates") - pmid:30116051 + pmid:14556719 - a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) - pmid:30116051 + pmid:22908190 - a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(Ub))) - pmid:30116051 + pmid:22908190 - a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") - - pmid:30116051 - a(CHEBI:Isorhynchophylline) increases p(HGNC:BECN1) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") - pmid:30116051 + pmid:22908190 - a(CHEBI:Isorhynchophylline) decreases a(HBP:HBP00016) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) - + + + pmid:22908190 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) + @@ -94268,88 +94776,88 @@

Statements

pmid:30116051 - complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) - pmid:30116051 + pmid:22908190 - a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) - pmid:30116051 + pmid:22908190 - a(PUBCHEM:16240819) increases bp(GO:macroautophagy) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") - pmid:30116051 + pmid:18930136 - a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") - pmid:30116051 + pmid:18930136 - p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") - pmid:30116051 + pmid:29626319 - a(CHEBI:"epothilone A") increases a(GO:microtubule) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") - pmid:30116051 + pmid:18930136 - a(CHEBI:"epothilone D") increases a(GO:microtubule) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) - pmid:30116051 + pmid:18930136 - a(CHEBI:"epothilone D") increases bp(GO:cognition) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") - pmid:30116051 + pmid:18930136 - a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) - pmid:30116051 + pmid:18930136 - a(PUBCHEM:129688311) decreases a(HBP:HBP00016) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) @@ -94358,25 +94866,25 @@

Statements

pmid:30116051 - a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:23528736 - a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:25374103 - a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) @@ -94385,97 +94893,97 @@

Statements

pmid:30116051 - a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") - pmid:30116051 + pmid:29626319 - act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) - pmid:30116051 + pmid:29626319 - act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) - pmid:30116051 + pmid:29626319 - act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) - pmid:30116051 + pmid:29626319 - a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation)) - pmid:30116051 + pmid:29758300 - a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy) + bp(GO:proteolysis) decreases bp(GO:"neuron death") - pmid:30116051 + pmid:14556719 - a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:proteolysis) association p(HGNC:UBA3) - pmid:30116051 + pmid:29626319 - a(CHEBI:ambroxol) increases p(HGNC:GBA) + bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) - pmid:30116051 + pmid:29758300 - a(CHEBI:ambroxol) increases bp(GO:macroautophagy) + bp(GO:"chaperone-mediated autophagy") decreases a(HBP:"protein aggregates") - pmid:30116051 + pmid:29758300 - a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:22908190 - a(CHEBI:ambroxol) decreases p(HGNC:SNCA) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) @@ -94484,7 +94992,7 @@

Statements

pmid:30116051 - a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) @@ -94493,67 +95001,61 @@

Statements

pmid:30116051 - a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) - pmid:30116051 + pmid:29758300 - a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) + bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) - pmid:30116051 + pmid:29758300 - a(PUBCHEM:46216556) decreases a(HBP:HBP00017) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:18930136 - a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:18930136 - a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) - - - - - - - pmid:30116051 + pmid:18930136 - complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) - pmid:23702978 + pmid:30116051 - p(HGNC:BIRC2) decreases complex(GO:ripoptosome) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) @@ -94562,43 +95064,43 @@

Statements

pmid:30116051 - p(HGNC:SESN2) increases act(p(FPLX:AMPK)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) - pmid:30116051 + pmid:29758300 - p(HGNC:SESN2) increases bp(GO:macroautophagy) + bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) - pmid:30116051 + pmid:22908190 - p(HGNC:SESN2) increases bp(GO:macroautophagy) + bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) - pmid:30116051 + pmid:18930136 - p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) - pmid:30116051 + pmid:24563850 - p(HGNC:PLG) increases deg(p(HGNC:SNCA)) + bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") @@ -94607,7 +95109,7 @@

Statements

pmid:30116051 - p(HGNC:KLK6) increases deg(p(HGNC:SNCA)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) @@ -94616,7 +95118,7 @@

Statements

pmid:30116051 - a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) @@ -94625,7 +95127,7 @@

Statements

pmid:30116051 - a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE)) + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) @@ -94634,7 +95136,7 @@

Statements

pmid:30116051 - a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) @@ -94643,151 +95145,153 @@

Statements

pmid:30116051 - a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) + bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) - pmid:30116051 + pmid:29024336 - a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) - pmid:30116051 + pmid:29024336 - a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases p(HGNC:IDE) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases sec(p(HGNC:IDE)) + bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) + bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) - pmid:29626319 + pmid:29024336 - a(CHEBI:somatostatin) increases p(HGNC:IDE) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases p(HGNC:MME) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases sec(p(HGNC:MME)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:30116051 + pmid:29024336 - a(CHEBI:somatostatin) increases act(p(HGNC:MME)) + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:29626319 + pmid:29024336 - a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta")) + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:30116051 + pmid:29024336 - p(HGNC:GRN) increases act(p(HGNC:MME)) + bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") - pmid:30116051 + pmid:25374103 - p(HGNC:GRN) decreases a(HBP:HBP00018) + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) - pmid:30116051 + pmid:29311797 - a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) - pmid:30116051 + pmid:29311797 - a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) + bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) - pmid:30116051 + pmid:29758300 - a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) + p(MESH:"Amyloid beta-Peptides", pmod(HBP:misfolding)) increases path(MESH:"Alzheimer Disease") + + - pmid:26195256 + pmid:29758300 - p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta")) + act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:"amyloid-beta") @@ -94796,436 +95300,450 @@

Statements

pmid:29626319 - p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") - pmid:18494933 + pmid:29758300 - act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK) + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25681682 + pmid:22908190 - p(HGNC:AGER) negativeCorrelation bp(GO:aging) + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25681682 + pmid:22908190 - p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24183963 + pmid:29758300 - act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) + bp(GO:endocytosis) association p(HGNC:BECN1) - pmid:18494933 + pmid:22908190 - act(p(HGNC:AGER)) increases p(HGNC:MAPK8, pmod(Ph)) + bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) - pmid:30116051 + pmid:22908190 - act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta")) + bp(GO:endocytosis) increases act(a(MESH:Neurons)) - pmid:29626319 + pmid:22908190 - p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta")) + bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") - pmid:29626319 + pmid:22908190 - p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") + bp(GO:endocytosis) increases bp(GO:memory) - pmid:29626319 + pmid:22908190 - p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") + bp(GO:endocytosis) increases bp(GO:learning) - pmid:26195256 + pmid:22908190 - act(p(HGNC:AQP4)) decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") - pmid:29626319 + pmid:22908190 - p(HGNC:AQP4) increases a(HP:"glymphatic system") + bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) - pmid:29626319 + pmid:22908190 - p(HGNC:AQP4) increases a(HP:"glymphatic system") + bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4") - pmid:23484434 + pmid:22908190 - a(CHEBI:6872) decreases a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) - pmid:23484434 + pmid:22908190 - a(CHEBI:8028) causesNoChange a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) - pmid:23484434 + pmid:22908190 - a(CHEBI:44932) causesNoChange a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) - pmid:23484434 + pmid:22908190 - a(CHEBI:3647) causesNoChange a(HBP:HBP00006) + bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:23484434 + pmid:22908190 - a(CHEBI:87637) decreases a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:23484434 + pmid:22908190 - a(CHEBI:22580) decreases a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:23484434 + pmid:22908190 - a(CHEBI:1457) decreases a(HBP:HBP00018) + bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) - pmid:23484434 + pmid:22908190 - a(CHEBI:10642) decreases a(HBP:HBP00018) + bp(GO:endocytosis) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:23484434 + pmid:22908190 - a(CHEBI:4806) decreases a(HBP:HBP00018) + bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:23484434 + pmid:18930136 - a(CHEBI:4806) decreases a(HBP:HBP00006) + bp(GO:endocytosis) increases a(GO:lysosome) - pmid:23484434 + pmid:29590627 - a(CHEBI:74460) decreases a(HBP:HBP00018) + bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:23484434 + pmid:29590627 - a(HBP:HBP00021) decreases a(HBP:HBP00018) + bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:23484434 + pmid:29590627 - a(HBP:HBP00019) decreases a(HBP:HBP00018) + bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:23484434 + pmid:28420982 - a(CHEBI:90) causesNoChange a(HBP:HBP00006) + bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) - pmid:23484434 + pmid:29686391 - a(CHEBI:18152) decreases a(HBP:HBP00006) + bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") - pmid:23484434 + pmid:29758300 - a(CHEBI:3441) decreases a(HBP:HBP00018) + p(HGNC:ATG7) increases bp(GO:macroautophagy) - pmid:23484434 + pmid:18930136 - a(CHEBI:3441) decreases a(HBP:HBP00006) + p(HGNC:ATG7) decreases path(HBP:Neurodegeneration) + + + + + + - pmid:23484434 + pmid:29758300 - a(CHEBI:6710) decreases a(HBP:HBP00006) + path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) - pmid:23484434 + pmid:22908190 - a(CHEBI:6710) decreases a(HBP:HBP00018) + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1") - - - - - pmid:23484434 + pmid:26751493 - a(CHEBI:112284) decreases a(HBP:HBP00006) + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") - pmid:23484434 + pmid:26631930 - a(HBP:HBP00020) decreases a(HBP:HBP00006) + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") - pmid:29024336 + pmid:26751493 - path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) - - - - - pmid:29024336 + pmid:26631930 - p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) - - - - - - - + + + pmid:29758300 + + p(FPLX:MAPK) increases p(HGNC:MAPT, pmod(Ph)) + - + + + pmid:29191965 + + p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + - + + + pmid:8702879 + + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) + - pmid:29202785 + pmid:8702879 - p(MGI:Mapt) increases bp(GO:"neuron migration") + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) - pmid:29202785 + pmid:8702879 - p(MGI:Mapt) increases bp(GO:"neuron differentiation") + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) + + + + - pmid:29202785 + pmid:29758300 - p(MGI:Mapt) increases bp(GO:"neuron maturation") + composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:30126037 + pmid:18930136 - p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") + p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt) increases bp(HP:Neurodegeneration) + p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") - pmid:30126037 + pmid:30116051 - p(MGI:Mapt) increases p(MGI:Cdkn2a) + p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) - pmid:30126037 + pmid:29758300 - p(MGI:Mapt) increases bp(GO:"cellular senescence") + p(HGNC:NBR1) association p(HGNC:MAPT) - pmid:30126037 + pmid:29758300 - p(MGI:Mapt) increases path(HP:"Brain atrophy") + p(HGNC:SNCA, pmod(HBP:misfolding)) increases a(HBP:"alpha-synuclein oligomers") - pmid:28408124 + pmid:29758300 - tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates") + a(HBP:"alpha-synuclein oligomers") increases path(HBP:neuroinflammation) - - - + + + pmid:29758300 + + a(HBP:"alpha-synuclein oligomers") increases bp(GO:"cell death") + @@ -95233,24 +95751,39 @@

Statements

- + + + pmid:29758300 + + complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") + - pmid:18096814 + pmid:14556719 - p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") - + + + pmid:28803412 + + p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") + - + + + pmid:14556719 + + p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") + @@ -95260,64 +95793,64 @@

Statements

- pmid:26400044 + pmid:29758300 - p(MGI:Mapt) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") - pmid:25995053 + pmid:14556719 - p(MGI:Mapt) association p(MGI:Dapk1) + p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") - pmid:25995053 + pmid:28803412 - p(MGI:Mapt) partOf complex(p(MGI:Dapk1), p(MGI:Mapt)) + p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") - - - pmid:29221819 + pmid:14556719 - p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) + p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") - - - pmid:28877763 + pmid:28803412 - p(MGI:Mapt) positiveCorrelation p(MGI:Syk) + p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") - - - - - - - + + + pmid:29758300 + + p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + - + + + pmid:29758300 + + p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + @@ -95327,7 +95860,12 @@

Statements

- + + + pmid:29334120 + + act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") + @@ -95343,513 +95881,556 @@

Statements

- pmid:29024336 + pmid:29758300 - bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") - pmid:29024336 + pmid:29758300 - bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") - pmid:29024336 + pmid:29758300 - bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053)) + a(CHEBI:lipid) regulates bp(GO:macroautophagy) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) + a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) - pmid:29024336 + pmid:22908190 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) - pmid:29024336 + pmid:22908190 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006) + path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100) + path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) - pmid:29024336 + pmid:18930136 - p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) - pmid:29024336 + pmid:29238289 - p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + path(MESH:Starvation) increases p(HGNC:MAPT) + + + + - pmid:29024336 + pmid:24561250 - p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") + a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) + + + + - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:"amyloid-beta") - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) + + + + - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + + + + - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") + complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(HBP:"Tau aggregates") - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) - pmid:29024336 + pmid:23528736 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) - pmid:29024336 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + p(FPLX:AMPK) increases bp(GO:macroautophagy) - pmid:29024336 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + p(FPLX:AMPK) decreases bp(GO:mitophagy) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317)) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777)) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) + p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph)) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) + p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) + act(p(FPLX:AMPK)) increases bp(GO:autophagy) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) + act(p(FPLX:AMPK)) increases bp(GO:autophagy) - pmid:30126037 + pmid:23528736 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) + p(FPLX:AMPK) increases bp(GO:autophagy) + + - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") + act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) + + - pmid:30126037 + pmid:23528736 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) + p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) + + - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) + p(HGNC:ULK1) increases bp(GO:macroautophagy) + + + + + + - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) + act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") + act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph)) - pmid:30126037 + pmid:30116051 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") + act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph)) - pmid:30126037 + pmid:23528736 - p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") + p(HGNC:ULK1) increases bp(GO:autophagy) + + + + - pmid:30126037 + pmid:29758300 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") + composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) + p(HGNC:TFEB) regulates a(GO:lysosome) - pmid:29024336 + pmid:29626319 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + p(HGNC:TFEB) increases act(a(GO:lysosome)) - pmid:29024336 + pmid:29626319 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + p(HGNC:TFEB) increases act(a(GO:lysosome)) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009) + p(HGNC:TFEB) regulates bp(GO:autophagy) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + p(HGNC:TFEB) increases bp(GO:autophagy) - pmid:29024336 + pmid:29626319 - p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + p(HGNC:TFEB) increases bp(GO:autophagy) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") + + - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:29024336 + pmid:29626319 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) - pmid:29024336 + pmid:29758300 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + p(HGNC:TFEB) increases act(p(HGNC:PTEN)) - pmid:29024336 + pmid:28803412 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") + p(HGNC:TFEB) decreases a(HBP:HBP00093) - pmid:29024336 + pmid:30116051 - p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) + p(HGNC:TFEB) increases bp(GO:macroautophagy) - pmid:29024336 + pmid:30116051 - p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) + tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) - pmid:29024336 + pmid:30116051 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + p(HGNC:TFEB) decreases a(HBP:HBP00018) - pmid:29024336 + pmid:30108137 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + p(HGNC:TFEB) decreases act(a(MESH:Lysosomes)) - - - - - + + + pmid:29626319 + + p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") + - pmid:29024336 + pmid:29626319 - complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) - + + + pmid:29626319 + + p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) + - pmid:29024336 + pmid:29626319 - complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") - - - + + + pmid:29626319 + + p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) + - pmid:29024336 + pmid:29758300 - complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB)) @@ -95858,79 +96439,74 @@

Statements

- - - pmid:29024336 + pmid:29758300 - a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") + complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) - pmid:28019679 + pmid:29758300 - a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) + complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) - pmid:28019679 + pmid:29758300 - a(CHEBI:paraquat) increases p(HGNC:CASP1) + bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:28019679 + pmid:29758300 - a(CHEBI:paraquat) increases p(HGNC:IL1B) + bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) - - - - - pmid:29024336 + pmid:18930136 - composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) - - - - - pmid:29024336 + pmid:21882945 - composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") - + + + pmid:21882945 + + bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers") + - pmid:29024336 + pmid:29758300 - composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + p(HGNC:PTEN) increases bp(GO:macroautophagy) @@ -95941,300 +96517,308 @@

Statements

- pmid:29024336 + pmid:29758300 - composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) - - - - - pmid:29024336 + pmid:29758300 - composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") - - - pmid:29024336 + pmid:29758300 - composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + p(HGNC:PICALM) positiveCorrelation a(CHEBI:"amyloid-beta") - - - - - pmid:29024336 + pmid:29758300 - composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") + p(HGNC:PICALM) increases a(CHEBI:"amyloid-beta") - pmid:23528736 + pmid:29758300 - a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) + p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) - pmid:23528736 + pmid:29626319 - a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) + p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) - pmid:29024336 + pmid:29626319 - a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta") - pmid:29024336 + pmid:29758300 - a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy") + p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") - pmid:29024336 + pmid:29758300 - a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") - pmid:29024336 + pmid:29758300 - a(HBP:HBP00055) decreases deg(p(MGI:Mapt)) + p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:29024336 + pmid:29758300 - a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy") + p(HGNC:PICALM) regulates bp(GO:macroautophagy) - pmid:29024336 + pmid:29758300 - a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:29024336 + pmid:26195256 - p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) + p(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pmid:29626319 - p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) + p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006) + p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))) + p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))) + p(HGNC:PICALM) partOf complex(GO:"Pick body") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) partOf complex(GO:"Cajal body") - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) + p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) - pmid:29024336 + pmid:27260836 - p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) - pmid:29024336 + pmid:29758300 - p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) + tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(HBP:"Tau aggregates")) - pmid:29024336 + pmid:29758300 - p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + p(HGNC:BIN1) increases bp(GO:endocytosis) - pmid:29215007 + pmid:29758300 - a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") - + + + pmid:29758300 + + p(HGNC:BIN1) increases bp(GO:autophagy) + - pmid:29215007 + pmid:29758300 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169) + p(HGNC:BIN1) decreases a(CHEBI:"amyloid-beta") - - - + + + pmid:29758300 + + p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") + - + + + pmid:29758300 + + p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) + - + + + pmid:29758300 + + p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) + - pmid:29215007 + pmid:29758300 - composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") + p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) @@ -96243,1206 +96827,1195 @@

Statements

- pmid:24760868 + pmid:29758300 - complex(GO:"filamentous actin") association p(HGNC:MAPT) + p(HGNC:TREM2) increases bp(GO:macroautophagy) - pmid:24760868 + pmid:29758300 - complex(GO:"filamentous actin") increases p(HGNC:MAPT) + p(HGNC:TREM2) increases bp(GO:"metabolic process") - pmid:24760868 + pmid:29758300 - complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) + p(HGNC:TREM2) increases bp(GO:"metabolic process") - pmid:17187063 + pmid:29758300 - complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) - pmid:29215007 + pmid:26195256 - a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:TREM2) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pmid:29626319 - a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) + p(HGNC:TREM2) association bp(GO:phagocytosis) - pmid:29215007 + pmid:29626319 - a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) + act(p(HGNC:TREM2)) increases bp(GO:phagocytosis) - - - - - pmid:29215007 + pmid:29626319 - complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) + act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - - - pmid:29215007 + pmid:29758300 - complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) + p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:29215007 + pmid:29758300 - a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) + p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) - - - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") + p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") + p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") + a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") - pmid:29215007 + pmid:27671637 - p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") + a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) - pmid:29215007 + pmid:25987199 - p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") + act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) - pmid:22072628 + pmid:22952452 - bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph)) + act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:TRAK1) - pmid:22072628 + pmid:22952452 - bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) + act(a(GO:mitochondrion)) positiveCorrelation p(HGNC:RHOT1) + + + + - pmid:29215007 + pmid:18930136 - p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170) + bp(GO:mitophagy) isA bp(GO:macroautophagy) - pmid:29215007 + pmid:30116051 - p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170) + bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) - + + + pmid:29758300 + + p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) + - pmid:29215007 + pmid:29758300 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) - + + + pmid:29758300 + + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) + - pmid:29215007 + pmid:29758300 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170) + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) - - - - - pmid:29215007 + pmid:29758300 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170) + p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) - - - - - pmid:29215007 + pmid:29758300 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - - - - - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) - pmid:29215007 + pmid:27594586 - p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") + p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) - - - - - pmid:29215007 + pmid:27594586 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") - - - - - + + + pmid:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) + - pmid:29215007 + pmid:27594586 - p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) - pmid:29215007 + pmid:26631930 - p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170) + p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) - + + + pmid:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) + - pmid:29215007 + pmid:27594586 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") - pmid:29215007 + pmid:27594586 - p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") - pmid:29215007 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) - pmid:21311567 + pmid:27594586 - act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) - pmid:23001711 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) - pmid:29215007 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) - pmid:29215007 + pmid:27594586 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416)) + p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045) - pmid:24251416 + pmid:27594586 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416)) + p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) - pmid:21882945 + pmid:29024336 - act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) - pmid:21882945 + pmid:29191965 - act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") - pmid:21311567 + pmid:26631930 - act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") + p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24251416 + pmid:26631930 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352)) + p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:24251416 + pmid:26631930 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413)) + p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") - pmid:25031639 + pmid:26631930 - p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8") + p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:"Tau oligomers") + + - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") - pmid:29215007 + pmid:27594586 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly") + composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") - pmid:17493042 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) - pmid:17493042 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) - pmid:24251416 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2") + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:29215007 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:29215007 + pmid:18930136 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly") + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) - pmid:24251416 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2") + path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) - pmid:29215007 + pmid:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) - pmid:29215007 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly") + a(CHEBI:Temsirolimus) decreases a(HBP:HBP00006) - pmid:17493042 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + a(CHEBI:Temsirolimus) decreases a(HBP:HBP00017) - pmid:17493042 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") - pmid:28760828 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates") + a(CHEBI:Temsirolimus) decreases a(HBP:HBP00016) - pmid:28760828 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HGNC:HDAC6) + a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) - pmid:29215007 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) - pmid:29215007 + pmid:29626319 - p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly") + a(CHEBI:Temsirolimus) increases bp(GO:autophagy) - - - - - pmid:24027553 + pmid:29626319 - p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta") - pmid:29540553 + pmid:29626319 - p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3) + a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:27041503 + pmid:29758300 - p(HGNC:MAPT, pmod(Ac)) decreases p(HGNC:WWC1) + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) - pmid:20869593 + pmid:18930136 - p(HGNC:MAPT, pmod(Ac)) negativeCorrelation act(p(HGNC:SIRT1)) + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) - pmid:20869593 + pmid:30145931 - p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8") + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) - pmid:24027553 + pmid:23528736 - p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) - pmid:24027553 + pmid:29626319 - p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) - pmid:24027553 + pmid:29626319 - p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) - pmid:24027553 + pmid:18930136 - act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") decreases path(HBP:Neurodegeneration) - - - - - - - - - pmid:24027553 + pmid:30145931 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) - pmid:24027553 + pmid:30145931 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:24027553 + pmid:29626319 - a(CHEBI:Thrombin) increases bp(GO:coagulation) + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) - pmid:24027553 + pmid:30145931 - a(CHEBI:Thrombin) increases bp(HBP:"neurite retraction") + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") - pmid:24027553 + pmid:23528736 - a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") - pmid:24027553 + pmid:30116051 - a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) - pmid:24027553 + pmid:30116051 - a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates") + a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) - pmid:24027553 + pmid:30116051 - a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") + a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) - pmid:24027553 + pmid:30116051 - act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00006) - pmid:24027553 + pmid:30116051 - act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00016) - pmid:24027553 + pmid:30116051 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00017) - pmid:24027553 + pmid:30116051 - act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) + a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:HBP00018) - pmid:24027553 + pmid:30116051 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") - pmid:24027553 + pmid:30116051 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) - pmid:24027553 + pmid:23528736 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") - - - - - pmid:24027553 + pmid:29626319 - p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") + a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta") - pmid:24027553 + pmid:29626319 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) + a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) - pmid:24027553 + pmid:29311797 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) + p(HGNC:MAPT, pmod(HBP:misfolding)) increases bp(GO:"cell death in response to oxidative stress") - pmid:24027553 + pmid:18930136 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) + p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) - pmid:24027553 + pmid:18930136 - act(p(HGNCGENEFAMILY:Calpains)) association a(HBP:Excitotoxicity) + p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) - pmid:24027553 + pmid:27260836 - act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration) + p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) - pmid:24027553 + pmid:29758300 - act(p(HGNC:NPEPPS)) association a(MESH:Brain) + a(CHEBI:paclitaxel) increases a(GO:microtubule) - pmid:24027553 + pmid:30116051 - p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L")) + a(CHEBI:paclitaxel) increases a(GO:microtubule) - pmid:24027553 + pmid:29758300 - p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L")) + a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) - pmid:24027553 + pmid:22941973 - p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain")) - pmid:24027553 + pmid:22941973 - p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) + a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) - pmid:24027553 + pmid:29758300 - p(HGNC:NPEPPS) decreases p(HGNC:MAPT) + a(CHEBI:epothilone) decreases path(MESH:Tauopathies) - pmid:24027553 + pmid:29758300 - p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) + a(CHEBI:epothilone) increases bp(GO:cognition) + + + + - pmid:24027553 + pmid:14556719 - p(HGNC:NPEPPS) decreases path(MESH:Paralysis) + composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) - pmid:24027553 + pmid:22908190 - p(HGNC:NPEPPS) decreases path(MESH:Gliosis) + composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) - pmid:24027553 + pmid:14556719 - p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) + act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) - pmid:24027553 + pmid:22908190 - p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) + a(MESH:Ubiquitin) association a(HBP:"paired helical filaments") - pmid:24027553 + pmid:22908190 - p(HGNC:NPEPPS) association bp(GO:autophagy) + a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") - pmid:24027553 + pmid:22908190 - p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia") + a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite") - pmid:24027553 + pmid:22908190 - p(MGI:Mapt, var("p.P301L")) association path(HBP:Neurodegeneration) + a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") - pmid:24027553 + pmid:22908190 - p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS) + a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") - pmid:24027553 + pmid:22908190 - p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") + a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") - pmid:24027553 + pmid:22908190 - p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L"))) + a(MESH:Ubiquitin) association a(GO:"Lewy body") - pmid:26751493 + pmid:22908190 - p(HGNC:PIN1) association p(HBP:"projection domain") + a(MESH:Ubiquitin) association a(GO:"Lewy body") - + + + pmid:22908190 + + a(MESH:Ubiquitin) association a(GO:"Pick body") + - pmid:26751493 + pmid:22908190 - p(HGNC:PIN1) association a(HBP:"projection domain") + act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:25899010 + pmid:22908190 - p(HGNC:PIN1) decreases a(HBP:Excitotoxicity) + a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) - pmid:25899010 + pmid:24457024 - p(HGNC:PIN1) negativeCorrelation p(HGNC:DAPK1) + a(MESH:Ubiquitin) regulates bp(GO:signaling) - - - pmid:24964035 + pmid:24457024 - p(HGNC:PIN1) increases deg(p(HGNC:SMAD2)) + a(MESH:Ubiquitin) regulates bp(GO:endocytosis) - pmid:24964035 + pmid:24457024 - p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2)) + a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) - pmid:23157676 + pmid:24457024 - act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") + a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") - pmid:26996941 + pmid:24457024 - act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235)) + act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") @@ -97451,386 +98024,411 @@

Statements

- - - pmid:22926167 + pmid:24457024 - act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:19401603 + pmid:24457024 - act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA)) + complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:19401603 + pmid:14556719 - act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) - pmid:24027553 + pmid:14556719 - deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") + p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) - pmid:24027553 + pmid:14556719 - p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates") + p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) - pmid:24027553 + pmid:14556719 - p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau")) + act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pmid:14556719 - p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1)) + p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub)) - pmid:23157676 + pmid:24457024 - p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") + + + + - pmid:23157676 + pmid:24457024 - p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") + complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) - pmid:23157676 + pmid:14556719 - p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite") + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") - pmid:24027553 + pmid:14556719 - act(a(MESH:Microtubules)) association act(p(HGNC:HTRA1)) + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") - pmid:29238289 + pmid:24457024 - act(a(MESH:Microtubules)) association p(HGNC:MAPT) + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") - pmid:28528849 + pmid:24457024 - a(HBP:"Tau fibrils") decreases a(MESH:"Dendritic Spines") + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") - pmid:29686391 + pmid:24457024 - a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle") + p(HGNC:UBA3) association bp(GO:proteolysis) - pmid:24027553 + pmid:22908190 - p(HGNC:MAPT, frag("?", "17kD")) association bp(GO:"apoptotic process") + p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) - pmid:24027553 + pmid:24457024 - p(HGNC:MAPT, frag("?", "17kD")) increases bp(HBP:"neurite retraction") + p(HGNC:UBA3) increases act(p(HGNC:UBA2)) - pmid:24027553 + pmid:24457024 - p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity) + p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:24027553 + pmid:24457024 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) + p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") + + + + - pmid:24027553 + pmid:24457024 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) + p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) - pmid:24027553 + pmid:14556719 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) + p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:24027553 + pmid:14556719 - a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) + p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) - pmid:24027553 + pmid:24457024 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + + + + - pmid:24027553 + pmid:24457024 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) + + + + + + - pmid:24027553 + pmid:22908190 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) - pmid:24027553 + pmid:22908190 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) - pmid:24027553 + pmid:24457024 - act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") + tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) - pmid:24027553 + pmid:18930136 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) + tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) - pmid:24027553 + pmid:14556719 - act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") - pmid:24027553 + pmid:14556719 - p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") + bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") - pmid:24027553 + pmid:14556719 - p(HBP:"Tau C3") increases bp(GO:"apoptotic process") + bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24027553 + pmid:18930136 - p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") + bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) - pmid:24027553 + pmid:14556719 - p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") + bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) - pmid:24027553 + pmid:14556719 - p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition) + bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) - pmid:25374103 + pmid:22908190 - p(HBP:"Tau C3") causesNoChange bp(GO:"cell death") + bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") - pmid:25374103 + pmid:18930136 - p(HBP:"Tau C3") negativeCorrelation p(HGNC:STUB1) + bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) - pmid:25374103 + pmid:18930136 - p(HBP:"Tau C3") positiveCorrelation act(p(HGNC:CASP3)) + bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) - pmid:25374103 + pmid:18930136 - p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) - pmid:25374103 + pmid:14556719 - p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") + + + + - pmid:24027553 + pmid:22908190 - p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process") + p(HBP:"20 S Proteasome") increases deg(p(HGNC:MAPT)) - + + + pmid:22908190 + + p(HBP:"20 S Proteasome") increases complex(a(HBP:"Tau aggregates"), p(HBP:"20 S Proteasome")) + - pmid:24027553 + pmid:16816118 - composite(p(HBP:"amyloid-beta oligomers"), p(HGNC:CASP3)) increases p(HBP:"Tau C3") + act(p(HBP:"20 S Proteasome")) negativeCorrelation p(RGD:Mapt, pmod(HBP:nitration)) - pmid:24027553 + pmid:16816118 - a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) + act(p(HBP:"20 S Proteasome")) negativeCorrelation bp(GO:"neurofibrillary tangle assembly") @@ -97841,351 +98439,367 @@

Statements

- pmid:24027553 + pmid:14556719 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub))) + complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") - pmid:24027553 + pmid:14556719 - p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub))) + p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) - pmid:24027553 + pmid:14556719 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + p(HGNC:PSMD4) association p(HGNC:PRKN) - pmid:24027553 + pmid:24457024 - p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) + p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4)) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates")) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) - pmid:24027553 + pmid:25036637 - act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers")) + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) - pmid:24027553 + pmid:14556719 - act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) + p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) + + + + + + + + + + + + - pmid:24027553 + pmid:14556719 - a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT) + deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) - pmid:24027553 + pmid:14556719 - a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) + deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) + + + + - pmid:24027553 + pmid:14556719 - act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) + complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") - pmid:21882945 + pmid:14556719 - a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") - pmid:21882945 + pmid:14556719 - a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") - pmid:24027553 + pmid:14556719 - a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates") + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") - pmid:24027553 + pmid:14556719 - path(MESH:"Alzheimer disease, familial, type 3") association p(HGNC:PSEN1) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") - pmid:24027553 + pmid:14556719 - bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L")) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates") + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") - pmid:24027553 + pmid:25036637 - bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S")) + bp(GO:"gene silencing") association p(HGNC:DCP1A) - pmid:24027553 + pmid:25036637 - bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S")) + bp(GO:"gene silencing") association p(HGNC:EDC3) - pmid:24027553 + pmid:25036637 - bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) + bp(GO:"gene silencing") association p(HGNC:DDX6) - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") + bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24027553 + pmid:23746257 - bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3")) + bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases p(HBP:"Tau C3") + path(MESH:Cachexia) increases bp(GO:"protein catabolic process") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, AT8") + path(MESH:Sepsis) increases bp(GO:"protein catabolic process") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, PHF1") + path(MESH:Acidosis) increases bp(GO:"protein catabolic process") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, 12E8") + a(MESH:Denervation) increases bp(GO:"protein catabolic process") - pmid:24027553 + pmid:14556719 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers")) + p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) @@ -98196,218 +98810,203 @@

Statements

- pmid:24027553 + pmid:14556719 - composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) + p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo)) - pmid:24027553 + pmid:27716675 - composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases deg(p(HGNC:MAPT)) + p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pmid:23229893 - a(MESH:"3-methyladenine") decreases bp(MESH:Autophagy) + p(HGNC:SUMO1) partOf a(GO:lysosome) - pmid:24027553 + pmid:19323834 - a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?")) + p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) - pmid:24027553 + pmid:18675254 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) - pmid:24027553 + pmid:18675254 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) - pmid:24027553 + pmid:16464864 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) - pmid:24027553 + pmid:16464864 - a(MESH:Trehalose) decreases a(HBP:"Tau aggregates") + p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo)) - pmid:24027553 + pmid:14556719 - a(MESH:Trehalose) decreases p(HGNC:MAPT) + p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination") - pmid:24027553 + pmid:14556719 - p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration) + p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) - pmid:30126037 + pmid:22908190 - p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a) + p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub))) - pmid:19491104 + pmid:22908190 - p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1) + p(MESH:Proteins, pmod(Ub)) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) - pmid:19491104 + pmid:14556719 - p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1)) + p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + + + + - pmid:19491104 + pmid:14556719 - p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1)) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") - pmid:28173111 + pmid:14556719 - p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") - - - - - pmid:24027553 + pmid:14556719 - composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub)) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") - - - - - pmid:24027553 + pmid:14556719 - composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") - - - - - pmid:16176937 + pmid:14556719 - p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - pmid:16176937 + pmid:14556719 - p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") - pmid:20133804 + pmid:14556719 - act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") + a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") - pmid:20133804 + pmid:14556719 - act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") + a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) - - - - - - - - - - - - - + + + pmid:14556719 + + a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) + @@ -98417,1449 +99016,1449 @@

Statements

- pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") - pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") - pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") - pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") - pmid:22764226 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - pmid:22156579 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8") + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") - pmid:22156579 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:22156579 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:25125464 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1) + path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:19459590 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") decreases act(p(HGNC:MAPT)) + path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:25031639 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT)) + a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:22156579 + pmid:14556719 - a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") - pmid:27671637 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") - pmid:22156579 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1") + a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") - pmid:25031639 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6)) + a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates") - pmid:25031639 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif") + a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") - pmid:25031639 + pmid:14556719 - a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1)) + a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(HBP:pretangles) + p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") + + - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") + p(HGNC:PRKN) association p(HGNC:PSMD4) + + - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") + p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") + p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") + p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub)) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:PRKN) association p(HGNC:GPR37) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") association a(GO:"Pick body") + p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + p(HGNC:PRKN) regulates p(HGNC:SNCA) - pmid:29686391 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco)) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) + p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) + p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) - pmid:25887395 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) association p(HGNC:CCNE1) - pmid:26631930 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) decreases p(HGNC:CCNE1) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:PRKN) decreases bp(GO:"cell death") + + - pmid:28528849 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub)) - pmid:28528849 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:memory) + p(HGNC:PRKN) association a(GO:"actin filament") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:memory) + p(HGNC:PRKN) regulates act(a(MESH:Actins)) - pmid:29191965 + pmid:14556719 - a(HBP:"Tau oligomers") decreases a(MESH:Neurons) + p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco)) - pmid:29686391 + pmid:22908190 - a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) + p(HGNC:PRKN) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22817713 + pmid:22908190 - a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) + p(HGNC:PRKN) increases bp(GO:mitophagy) - pmid:22817713 + pmid:22908190 - a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) + p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") - pmid:29686391 + pmid:23528736 - a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") - pmid:29686391 + pmid:14556719 - tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases path(MESH:Disease) + p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) - pmid:22817713 + pmid:14556719 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) - pmid:28420982 + pmid:28803412 - a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") + p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") - pmid:28420982 + pmid:30116051 - a(HBP:"Tau oligomers") decreases a(GO:synapse) + p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") - pmid:22486774 + pmid:30116051 - a(HBP:"Tau oligomers") partOf a(GO:synapse) + p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) - pmid:28420982 + pmid:30116051 - a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") + p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") - pmid:26631930 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:cognition) + path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") + path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) + path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils") + path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival") + path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") association p(HGNC:PRNP) + path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases act(a(GO:microtubule)) + path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) - pmid:28420982 + pmid:30126037 - a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") + path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) + p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") + p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders") - - - pmid:28420982 - - a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) - + - pmid:28420982 + pmid:14556719 - a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) + complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") - - - pmid:26631930 - - a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration) - + + + - pmid:26631930 + pmid:14556719 - a(HBP:"Tau oligomers") decreases a(MESH:"Dendritic Spines") + complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub)) - pmid:22817713 + pmid:29121589 - a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") + p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) - pmid:22817713 + pmid:14556719 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) - - - pmid:22817713 - - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) - + - pmid:22817713 + pmid:14556719 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) + complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) - - - pmid:26671985 - - act(a(HBP:"Tau oligomers")) increases a(HBP:neurotoxicity) - + - pmid:26671985 + pmid:14556719 - act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon)) + p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone")) - pmid:26671985 + pmid:14556719 - act(a(HBP:"Tau oligomers")) positiveCorrelation p(HBP:"phosphatase-activating domain") + p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) - pmid:27716675 + pmid:14556719 - a(HBP:"Tau oligomers") positiveCorrelation a(HBP:neuroinflammation) + p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) - - - pmid:27716675 - - a(HBP:"Tau oligomers") increases a(HBP:"Pathological Tau Spreading") - + - pmid:27574109 + pmid:14556719 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) - pmid:27574109 + pmid:29191965 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) - pmid:27574109 + pmid:14556719 - a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") + p(HGNC:GPR37) association p(HGNC:PRKN) + + - pmid:27574109 + pmid:14556719 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) - pmid:27574109 + pmid:14556719 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") - pmid:27574109 + pmid:14556719 - a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + bp(GO:"response to unfolded protein") increases bp(GO:"cell death") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers") + bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") - pmid:29686391 + pmid:14556719 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") - pmid:29686391 + pmid:23746257 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) - pmid:29686391 + pmid:24563850 - a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) - pmid:29686391 + pmid:24563850 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin) + bp(GO:"response to endoplasmic reticulum stress") decreases bp(HBP:misfolding) - pmid:29686391 + pmid:24563850 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin") + bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") - pmid:27574109 + pmid:24563850 - bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") + bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") - pmid:27574109 + pmid:24563850 - bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau") + bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") - pmid:27574109 + pmid:23702978 - a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") + bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") - - - pmid:27574109 - - a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") - + + + - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") + composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") + a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") + bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") + bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") + bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") - pmid:27574109 + pmid:23746257 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") + bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") - pmid:27574109 + pmid:23746257 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") + bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) - pmid:27574109 + pmid:23746257 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis) - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") - pmid:27574109 + pmid:29807032 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) + p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN) + + - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) + p(HGNC:SNCAIP) association p(HGNC:SNCA) - - - pmid:27574109 - - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") - + - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") + p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) + p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) - - - pmid:27574109 - - a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") - + + + - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") + p(HGNC:CCNE1) association p(HGNC:PRKN) - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") + p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") + + + + - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") + composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:AIMP2) increases bp(GO:"cell death") + + - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") association a(GO:"Pick body") + p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) + p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub)) - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport") - pmid:27574109 + pmid:14556719 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) + + - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") + bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub)) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + a(GO:"actin filament") association p(HGNC:PRKN) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") + p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") + act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") - pmid:27574109 + pmid:22908190 - a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") + p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) + + + + - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") - pmid:27574109 + pmid:14556719 - a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") + p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:27574109 + pmid:23528736 - a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") + p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") - pmid:27574109 + pmid:23528736 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") + + - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") - pmid:27574109 + pmid:22908190 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA) - pmid:27574109 + pmid:22908190 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:27574109 + pmid:22908190 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") + a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN) + + + + - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) + + + + - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) + + - pmid:27574109 + pmid:29191965 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:TH) regulates a(CHEBI:dopamine) - pmid:27574109 + pmid:29191965 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:TH) regulates a(CHEBI:serotonin) - pmid:27574109 + pmid:29191965 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + p(HGNC:TH) regulates act(p(HGNC:DDC)) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") @@ -99868,21 +100467,16 @@

Statements

- pmid:29191965 + pmid:14556719 - p(HBP:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) + p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) - - - pmid:17493042 - - p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) - + @@ -99890,135 +100484,131 @@

Statements

- pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo)) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") + + - pmid:27574109 + pmid:29311797 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) - pmid:27574109 + pmid:29311797 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) - pmid:27574109 + pmid:24457024 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) - - - pmid:27574109 - - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - + - - - pmid:27574109 - - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - + + + - pmid:27574109 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") + + pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau") @@ -100027,7 +100617,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") @@ -100036,7 +100626,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) @@ -100045,7 +100635,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) @@ -100054,7 +100644,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") @@ -100063,7 +100653,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") @@ -100072,7 +100662,7 @@

Statements

pmid:27574109 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") @@ -100081,250 +100671,254 @@

Statements

pmid:27574109 - a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers") + path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) - pmid:27574109 + pmid:29311797 - a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) - pmid:27574109 + pmid:26195256 - a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers") + path(MESH:"Pick Disease of the Brain") association path(MESH:"Alzheimer Disease") - pmid:27574109 + pmid:27260836 - a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") - pmid:25374103 + pmid:22057784 - bp(GO:"anterograde axonal transport") negativeCorrelation p(HGNC:MAPT) + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) - pmid:25374103 + pmid:22057784 - bp(GO:"anterograde axonal transport") decreases a(GO:microtubule) + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:25374103 + pmid:22057784 - bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) + + + + - pmid:27574109 + pmid:14556719 - a(HBP:pretangles) association a(HBP:"Tau oligomers") + composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") - pmid:27574109 + pmid:14556719 - a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") + a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) - pmid:27574109 + pmid:14556719 - a(HBP:pretangles) association p(HGNC:MAPT) + a(CHEBI:lactacystin) increases bp(GO:"cell death") - pmid:23407988 + pmid:22908190 - a(HBP:pretangles) increases complex(GO:"dendritic tree") + a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") - pmid:18239272 + pmid:30145931 - a(HBP:pretangles) association p(HGNC:TTBK1) + a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) - pmid:18239272 + pmid:23528736 - a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) - pmid:18239272 + pmid:24027553 - a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") + a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) - pmid:27574109 + pmid:24027553 - a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") + a(CHEBI:lactacystin) increases p(HGNC:MAPT) - pmid:27574109 + pmid:23528736 - a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") + a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) - pmid:27574109 + pmid:24027553 - a(HBP:"Braak_Stage I") association p(HGNC:MAPT) + a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) - pmid:28176663 + pmid:24027553 - a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") + a(MESH:Prions) increases path(MESH:"Prion Diseases") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") + a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") + path(MESH:"Prion Diseases") increases path(MESH:Dementia) - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:"Prion Diseases") increases path(MESH:Death) - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) + path(MESH:"Prion Diseases") increases bp(GO:"neuron death") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Prion Diseases") increases path(MESH:Gliosis) - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") + path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:27574109 + pmid:14556719 - a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") @@ -100333,316 +100927,333 @@

Statements

+ + + + - pmid:27574109 + pmid:14556719 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") - pmid:27574109 + pmid:14556719 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:27574109 + pmid:14556719 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") + p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph)) + p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) - pmid:17403556 + pmid:18930136 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) + p(HGNC:RNF19A) decreases bp(GO:"cell death") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + - pmid:18096814 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") - pmid:18096814 + pmid:14556719 - a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") - pmid:20133804 + pmid:14556719 - p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) + p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates") - + + + pmid:14556719 + + p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta antibody, NU1") decreases act(a(HBP:"amyloid-beta derived diffusible ligands")) + p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome")) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c")) - pmid:17403556 + pmid:14556719 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) + p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) - pmid:28420982 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes) + p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") - pmid:28420982 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) - pmid:28420982 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) - pmid:17078951 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA) + p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") - pmid:11943212 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270") + p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") + + + + - pmid:28176663 + pmid:14556719 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose") + p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) - pmid:17403556 + pmid:14556719 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:HTT) decreases act(complex(GO:"proteasome complex")) - pmid:17403556 + pmid:14556719 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") + p(HGNC:HTT) increases bp(GO:"cell cycle arrest") + + - pmid:17403556 + pmid:14556719 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") - pmid:17403556 + pmid:26631930 - a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(Ac, Lys)) - pmid:17403556 + pmid:14556719 - a(CHEBI:LY294002) decreases bp(GO:"signal transduction") + p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") - pmid:17403556 + pmid:14556719 - a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") - - - pmid:17403556 + pmid:24457024 - complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) @@ -100651,866 +101262,908 @@

Statements

- - - pmid:27671637 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") - + - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") + p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) - - - pmid:27671637 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") - + - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") + composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates") - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") + composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") + + + + - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") + composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates") - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") + composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") + a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates") - pmid:27671637 + pmid:14556719 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) + a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) + p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) - pmid:27671637 + pmid:29626319 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) + p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) - pmid:29202785 + pmid:25374103 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + p(FPLX:Caspase) positiveCorrelation path(MESH:Tauopathies) - pmid:29202785 + pmid:25374103 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + act(p(FPLX:Caspase)) negativeCorrelation p(HGNC:STUB1) - pmid:29202785 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) - pmid:29202785 + pmid:24027553 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29202785 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:29202785 + pmid:29626319 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:29202785 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + bp(GO:"proteasomal protein catabolic process") decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) - pmid:29202785 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(Ub))) - pmid:29202785 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63))) + + + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Microglia) + composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) + act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) + act(p(HGNC:VCP)) regulates a(GO:autophagosome) - pmid:29202785 + pmid:24457024 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") - pmid:29202785 + pmid:24457024 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + p(HGNC:VCP) increases bp(GO:"protein ubiquitination") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") + a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) - pmid:29202785 + pmid:22817713 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") + a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") - pmid:29202785 + pmid:18239272 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) + a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") - pmid:27671637 + pmid:22908190 - a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") + p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") + p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") + p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") + p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) + p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) + p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) association a(HBP:"paired helical filaments") + + + + + + - pmid:27671637 + pmid:26751493 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") + p(HBP:"Tau aggregates") association a(CHEBI:heparin) - pmid:27671637 + pmid:26751493 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") + p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) - pmid:27671637 + pmid:26751493 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) + p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) - pmid:27671637 + pmid:26751493 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") + p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) - pmid:27671637 + pmid:19517062 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") + p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process") - pmid:27671637 + pmid:19517062 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") + p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death") - pmid:27671637 + pmid:28760828 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") + p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) - pmid:27671637 + pmid:28500862 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") + p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") + a(GO:"Lewy body") association a(MESH:Ubiquitin) - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) + a(GO:"Lewy body") association a(MESH:Ubiquitin) - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) + a(GO:"Lewy body") association p(HGNC:MAPT) - pmid:29202785 + pmid:18930136 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + a(GO:"Lewy body") association p(HGNC:SQSTM1) + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + a(GO:"Pick body") association p(HGNC:MAPT) - pmid:29202785 + pmid:27574109 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + a(GO:"Pick body") association p(HGNC:MAPT) - pmid:28528849 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + a(GO:"Pick body") association a(MESH:Ubiquitin) - pmid:27671637 + pmid:27574109 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) + a(GO:"Pick body") association a(HBP:"Tau oligomers") - pmid:27671637 + pmid:27574109 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") + a(GO:"Pick body") association a(HBP:"phosphatase-activating domain") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) + p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") + p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) + p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") - pmid:27671637 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) + path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) - pmid:27671637 + pmid:26631930 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) + + + + + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates") + complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub)) - pmid:29202785 + pmid:24457024 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") - pmid:28528849 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration) + complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(HBP:"20 S Proteasome")) + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) + complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) + + + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) + complex(a(GO:"proteasome regulatory particle"), a(HBP:"paired helical filaments")) decreases act(complex(GO:"proteasome complex")) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) + p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation)) increases p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation), pmod(Ub)) - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) + p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29202785 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) + p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + + - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) + p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29202785 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(HBP:"UBB+1") decreases bp(GO:memory) - pmid:29202785 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") + p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") - pmid:29202785 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") + p(HBP:"UBB+1") decreases bp(GO:"protein deubiquitination") - pmid:29202785 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) + p(HBP:"UBB+1") decreases act(p(FPLX:Proteasome)) - pmid:28528849 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) + p(HBP:"UBB+1") increases bp(HP:Neurodegeneration) - pmid:28528849 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau fibrils") + p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") - pmid:28528849 + pmid:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau oligomers") + p(HBP:"UBB+1") increases act(p(HGNC:TP53)) - pmid:28528849 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(HBP:"Tau oligomers", var("p.Lys280del")) + p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:28528849 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") + p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly))) - pmid:28528849 + pmid:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange bp(GO:"cellular calcium ion homeostasis") + p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") - pmid:27671637 + pmid:22908190 - a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") - pmid:27671637 + pmid:22908190 - a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) - pmid:27671637 + pmid:22908190 - a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) + p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(Ub))) - pmid:27671637 + pmid:22908190 - a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) + + + + + + + + + + - pmid:27671637 + pmid:22908190 - a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27807169 + pmid:22908190 - a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) + deg(p(FPLX:PKA, pmod(Ub))) increases act(p(FPLX:PKA)) - pmid:22156579 + pmid:22908190 - a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) + p(HGNC:ARC) regulates bp(GO:"synapse maturation") - pmid:27671637 + pmid:22908190 - p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) + act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) @@ -101519,31 +102172,19 @@

Statements

- - - pmid:27671637 - - a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - + - pmid:27671637 + pmid:22908190 - a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - - - pmid:22833681 - - a(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) - - @@ -101552,292 +102193,305 @@

Statements

- pmid:27671637 + pmid:22908190 - composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") + complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") - pmid:27671637 + pmid:22908190 - p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + a(GO:caveola) increases bp(GO:"plasma membrane invagination") - pmid:27671637 + pmid:22908190 - p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) + bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") - pmid:27671637 + pmid:29590627 - p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") - pmid:27671637 + pmid:29590627 - p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") + bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") - pmid:27671637 + pmid:22908190 - p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:RAB7A) increases a(GO:endosome) - pmid:27671637 + pmid:22908190 - p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") + p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27671637 + pmid:22908190 - a(CHEBI:adenosine) increases act(p(MGI:Adora1)) + p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) - pmid:27671637 + pmid:22908190 - a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) + p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") - pmid:27671637 + pmid:18930136 - a(CHEBI:adenosine) decreases act(a(GO:presynapse)) + p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") + + - pmid:27671637 + pmid:29238289 - a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:RAB7A) association p(HGNC:MAPT) - pmid:21882945 + pmid:22908190 - a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") - pmid:27671637 + pmid:22908190 - act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) + act(a(GO:endosome)) decreases path(HBP:Neurodegeneration) - pmid:27671637 + pmid:22908190 - act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) + complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) - pmid:27671637 + pmid:22908190 - act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) - pmid:27671637 + pmid:22908190 - a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) + a(MESH:Cathepsins) regulates deg(a(CHEBI:"amyloid-beta")) - pmid:27671637 + pmid:22908190 - a(PUBCHEM:64627) increases act(a(MESH:Neurons)) + sec(a(MESH:Cathepsins)) increases bp(GO:"apoptotic process") - pmid:27671637 + pmid:22908190 - a(PUBCHEM:64627) increases act(a(GO:presynapse)) + p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) - pmid:27671637 + pmid:22908190 - a(PUBCHEM:64627) increases a(GO:"dendritic spine") + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) - pmid:27671637 + pmid:22908190 - a(PUBCHEM:64627) decreases a(MESH:Axons) + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) - pmid:27671637 + pmid:18930136 - a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) - pmid:27671637 + pmid:29626319 - a(MESH:"BSc 3094") increases act(a(GO:presynapse)) + bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") - + + + pmid:29626319 + + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + - pmid:27671637 + pmid:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) - pmid:27671637 + pmid:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) - pmid:27671637 + pmid:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) + bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") - pmid:27671637 + pmid:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) + bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) + + + + + + - pmid:27671637 + pmid:22908190 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) + complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) - pmid:27671637 + pmid:29024336 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") + a(GO:"late endosome") increases deg(p(MGI:Mapt)) - pmid:27671637 + pmid:29024336 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") + a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:27671637 + pmid:29024336 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") + a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:27671637 + pmid:29590627 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") + a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) - pmid:27671637 + pmid:29590627 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") + a(GO:"late endosome") association a(HBP:"Tau aggregates") @@ -101848,1303 +102502,1351 @@

Statements

- pmid:27671637 + pmid:22908190 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") + complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) - pmid:28784767 + pmid:29590627 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") + a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) - pmid:28784767 + pmid:29590627 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") + a(GO:"early endosome") association a(HBP:"Tau aggregates") - pmid:26751493 + pmid:18930136 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) - pmid:28784767 + pmid:22908190 - p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) + bp(GO:"response to nutrient") regulates p(HGNC:MTOR) - pmid:28784767 + pmid:22908190 - p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates") + bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") - pmid:18239272 + pmid:22908190 - p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") + bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") - pmid:18239272 + pmid:22908190 - p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") + bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") - pmid:18239272 + pmid:22908190 - p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") + bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) - pmid:28784767 + pmid:22908190 - p(HBP:"Tau epitope, AT8") increases bp(HBP:"Tau aggregates") + bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) - pmid:27087442 + pmid:22908190 - p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25") + bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) - pmid:25125464 + pmid:22908190 - p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1) + a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") - pmid:19459590 + pmid:27574109 - p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:MAPT)) + a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") - pmid:19459590 + pmid:27574109 - p(HBP:"Tau epitope, AT8") decreases act(p(HGNC:MAPT)) + a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") - pmid:22833681 + pmid:27574109 - p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt)) + a(HBP:"Braak_Stage II") association p(HGNC:MAPT) - pmid:22253473 + pmid:28176663 - p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) + a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + + + + - pmid:20869593 + pmid:22908190 - p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac)) + p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:20869593 + pmid:22908190 - p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) + p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) - pmid:19623258 + pmid:22908190 - p(HBP:"Tau epitope, AT8") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) + p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") - pmid:28784767 + pmid:22908190 - p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) - pmid:28784767 + pmid:22908190 - p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) - pmid:28784767 + pmid:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn") + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:21882945 + pmid:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") - pmid:28784767 + pmid:22908190 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) - pmid:28784767 + pmid:22908190 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) - pmid:28784767 + pmid:22908190 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) - pmid:28784767 + pmid:22908190 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") + act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta") - pmid:28784767 + pmid:22908190 - p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn") + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") - pmid:28784767 + pmid:22908190 - act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") - pmid:25673844 + pmid:30116051 - p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") + act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) - pmid:25673844 + pmid:27607061 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2)) - pmid:25673844 + pmid:27607061 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") - pmid:25673844 + pmid:22908190 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25673844 + pmid:22908190 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) - pmid:25673844 + pmid:22908190 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") - pmid:25673844 + pmid:22908190 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + p(HGNC:ATP6V0A1, pmod(NGlyco)) increases bp(GO:"pH reduction") + + + + + + + + + + - pmid:28784767 + pmid:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8") + complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1)) increases act(p(HGNC:RAB5A)) - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:24406748 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + bp(GO:"response to acidic pH") increases a(HBP:"amyloid-beta oligomers") - pmid:29590627 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") - pmid:29590627 + pmid:26631930 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") - pmid:29590627 + pmid:26631930 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") - pmid:29590627 + pmid:26631930 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") - pmid:29590627 + pmid:26631930 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration) - pmid:29590627 + pmid:29626319 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") + p(HGNC:RIN1) decreases bp(GO:"fear response") - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") + p(HGNC:RIN1) decreases bp(GO:memory) - pmid:29590627 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) + p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") - pmid:28877763 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis) - pmid:28877763 + pmid:22908190 - p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CST3) decreases act(a(GO:synapse)) - pmid:28877763 + pmid:24563850 - p(HGNC:MAPT, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates") + a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") - pmid:24406748 + pmid:21882945 - p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") - pmid:24406748 + pmid:21882945 - p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) - pmid:24406748 + pmid:23746257 - p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") + act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") - pmid:24406748 + pmid:23746257 - p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) + act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") - pmid:29590627 + pmid:23746257 - a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) + bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) - pmid:28420982 + pmid:23746257 - a(CHEBI:dextran) association a(HBP:"Tau aggregates") + bp(GO:"protein refolding") association act(p(FPLX:HSPA)) - pmid:29590627 + pmid:23746257 - a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"protein refolding") association act(p(FPLX:HSPA)) - pmid:29590627 + pmid:23746257 - a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"protein refolding") association act(p(FPLX:HSP90)) + + + + - pmid:25887395 + pmid:23746257 - a(CHEBI:heparin) decreases a(HBP:"Tau aggregates") + complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") - pmid:29988016 + pmid:23746257 - a(CHEBI:heparin) increases a(HBP:"Tau aggregates") + bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) - pmid:25887395 + pmid:23746257 - a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + bp(GO:"protein secretion") association p(FPLX:HSP90) - pmid:29988016 + pmid:23746257 - a(CHEBI:heparin) increases p(HGNC:MAPT, var("?")) + bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) - pmid:29686391 + pmid:23746257 - a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) + + + + + + - pmid:29686391 + pmid:23746257 - a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") - pmid:26751493 + pmid:21882945 - a(CHEBI:heparin) association p(HBP:"Tau aggregates") + p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph)) + + + + - pmid:27601475 + pmid:23746257 - a(CHEBI:heparin) increases p(HBP:"Tau aggregates") + complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") + + + + - pmid:26751493 + pmid:23746257 - a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + + + + - pmid:29590627 + pmid:23746257 - a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) - pmid:29590627 + pmid:23746257 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) - pmid:29590627 + pmid:25784053 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) - pmid:29686391 + pmid:29311797 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) - pmid:29590627 + pmid:25784053 - a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) - pmid:29590627 + pmid:23746257 - a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:29590627 + pmid:21882945 - a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) + p(HGNC:CDC37) regulates act(p(FPLX:HSP90)) - pmid:29590627 + pmid:21367866 - a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) - pmid:29590627 + pmid:25036637 - a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:29590627 + pmid:25036637 - a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) - pmid:29590627 + pmid:25036637 - bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) - pmid:29590627 + pmid:25036637 - bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) - pmid:29590627 + pmid:25036637 - bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) - pmid:24760868 + pmid:25036637 - bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) - pmid:27041503 + pmid:25036637 - bp(GO:"actin filament polymerization") negativeCorrelation bp(MESH:"Long-Term Potentiation") + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) - pmid:29590627 + pmid:25036637 - bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) - pmid:29590627 + pmid:25036637 - bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) - pmid:26751493 + pmid:25036637 - bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) - pmid:26751493 + pmid:25036637 - bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) - - - - - pmid:29590627 + pmid:25036637 - composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) - - - - - pmid:29590627 + pmid:25036637 - composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDC37) association p(HGNC:FKBP5) - pmid:22611162 + pmid:25036637 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) - pmid:26631930 + pmid:21882945 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) - pmid:26631930 + pmid:29311797 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + p(HGNC:CDC37) increases p(HGNC:MAPT) - pmid:26631930 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) increases path(HBP:neurotoxicity) + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:22611162 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) - pmid:26631930 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5)) - pmid:26631930 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) decreases p(HBP:"4R tau") + p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) - pmid:26631930 + pmid:21367866 - p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau") + p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) - pmid:26631930 + pmid:23746257 - p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory) + p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:26631930 + pmid:21882945 - p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) - pmid:26631930 + pmid:29311797 - p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:26631930 + pmid:21882945 - p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") + p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) - pmid:26631930 + pmid:21882945 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) + p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) - pmid:11606569 + pmid:29311797 - p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) + p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:11606569 + pmid:29311797 - p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif") + p(HGNC:AHSA1) increases a(HBP:"Tau oligomers") - pmid:11606569 + pmid:29311797 - p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif") + p(HGNC:AHSA1) increases bp(GO:"neuron apoptotic process") - pmid:22611162 + pmid:29311797 - p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(HBP:"Tau aggregates") + p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") - pmid:22611162 + pmid:29311797 - p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates") + p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") - pmid:22611162 + pmid:23746257 - p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + bp(GO:"behavioral response to starvation") association bp(HBP:Proteostasis) - pmid:22611162 + pmid:23746257 - p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") - pmid:22611162 + pmid:23746257 - p(HGNC:MAPT, var("p.Val277Met")) increases path(HBP:neurotoxicity) + p(FPLX:Proteasome) increases bp(GO:"protein unfolding") - pmid:22611162 + pmid:25784053 - p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") + p(FPLX:Proteasome) increases bp(MESH:Proteolysis) - pmid:22611162 + pmid:25784053 - a(PUBCHEM:25096749) increases bp(GO:locomotion) + p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:22611162 + pmid:25784053 - a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates") + act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22611162 + pmid:30145931 - a(HBP:bb14) increases bp(GO:locomotion) + act(p(FPLX:Proteasome)) decreases path(HBP:neurotoxicity) - pmid:22611162 + pmid:30145931 - a(HBP:cmp16) decreases a(HBP:"Tau fibrils") + act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) - pmid:22611162 + pmid:30145931 - a(HBP:cmp16) increases bp(GO:locomotion) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262))) - pmid:22611162 + pmid:30145931 - a(HBP:cmp16) decreases bp(HP:Neurodegeneration) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 356))) + + + + + + + + + + - pmid:24760868 + pmid:23746257 - p(HGNC:DLG4, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") - pmid:26751493 + pmid:23746257 - p(HGNC:DLG4) association p(HBP:"projection domain") + p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:26751493 + pmid:25036637 - p(HGNC:DLG4) association a(HBP:"projection domain") + p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) - pmid:24760868 + pmid:25036637 - p(MESH:Actins, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) - pmid:24760868 + pmid:25036637 - p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) - + + + pmid:25036637 + + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + - pmid:24760868 + pmid:21882945 - complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) association bp(GO:"long-term synaptic potentiation") + p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17187063 + pmid:21882945 - complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration) + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) - + + + pmid:21882945 + + p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + - pmid:24760868 + pmid:17954934 - a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) - pmid:24760868 + pmid:17954934 - a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) - pmid:24760868 + pmid:17954934 - a(MESH:jasplakinolide) increases p(HGNC:MAPT) + p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) - pmid:24760868 + pmid:17954934 - a(MESH:jasplakinolide) increases p(HGNC:GRIA1) + p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:24760868 + pmid:17954934 - a(MESH:jasplakinolide) decreases p(HGNC:FYN) + p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) - pmid:24760868 + pmid:23746257 - a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") + a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) - pmid:24760868 + pmid:23746257 - a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") + a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) - pmid:24760868 + pmid:23746257 - a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) + a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(Ph)) @@ -103153,330 +103855,301 @@

Statements

- pmid:24760868 + pmid:23746257 - complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) association a(MESH:"Dendritic Spines") + p(FPLX:EIF2B, pmod(Ph)) decreases act(p(FPLX:EIF2B)) - - - pmid:29202785 + pmid:23746257 - a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) - pmid:29202785 + pmid:25784053 - a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) - pmid:29202785 + pmid:30116051 - a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) - pmid:29202785 + pmid:21882945 - a(CHEBI:doxycycline) decreases p(MGI:Wnt3) + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) - pmid:21734277 + pmid:21882945 - p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) - pmid:21734277 + pmid:30116051 - p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") + a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) - pmid:21734277 + pmid:30116051 - p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport") + a(CHEBI:geldanamycin) decreases a(HBP:HBP00016) - pmid:21734277 + pmid:24027553 - p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1")) + a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) - pmid:21734277 + pmid:21882945 - p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) + + - pmid:21734277 + pmid:23746257 - act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18")) + composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") - pmid:21734277 + pmid:23746257 - p(HBP:"6P tau") decreases bp(GO:"anterograde axonal protein transport") + composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(HBP:"huntingtin aggregates") - - - pmid:21734277 - - p(HBP:"6P tau") causesNoChange bp(GO:"retrograde axonal protein transport") - + - pmid:21734277 + pmid:24457024 - act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") + complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) - pmid:21734277 + pmid:24457024 - act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) - pmid:21734277 + pmid:24457024 - p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau")) + p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) - - - pmid:21734277 - - p(HBP:"6D tau", frag("2_18")) association bp(GO:"anterograde axonal protein transport") - + - - - pmid:21734277 - - p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") - + - pmid:21734277 + pmid:24457024 - p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") + p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) - - - pmid:21734277 - - p(HBP:"6D tau", frag("2_18")) causesNoChange bp(GO:"retrograde axonal protein transport") - + - pmid:21734277 + pmid:24457024 - p(HBP:"6D tau", frag("2_18")) decreases p(HBP:"endogenous axoplasmic phosphatases") + path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - pmid:21734277 + pmid:24457024 - p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) + p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) - - - pmid:21734277 - - p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) - + - pmid:21734277 + pmid:24457024 - p(HBP:"6D tau", frag("2_18")) association p(HBP:TNT1) + complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:21734277 + pmid:24457024 - act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") + p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) - - - pmid:21734277 - - act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") - + - pmid:21734277 + pmid:24457024 - a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18"))) + complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") + + + + - pmid:21734277 + pmid:24457024 - a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18"))) + complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:21734277 + pmid:24457024 - p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport") + complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") - pmid:21734277 + pmid:24457024 - p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport") + complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") + + - pmid:21734277 + pmid:24457024 - p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18"))) + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) - pmid:21734277 + pmid:24457024 - p(HBP:"AT8 tau", pmod(Ph)) association p(HGNC:MAPT, pmod(Ph)) + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") - pmid:21734277 + pmid:24457024 - p(HBP:"AT8 tau", pmod(Ph)) association path(MESH:Tauopathies) + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") - pmid:21734277 + pmid:24457024 - p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport") + a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - - - pmid:21734277 - - p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport") - + - pmid:21734277 + pmid:24457024 - p(HBP:TNT1) association p(HBP:"6D tau", frag("2_18")) + complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") @@ -103487,766 +104160,753 @@

Statements

- pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HBP:"Tau fibrils", var("p.Lys280del")) + complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") + complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") + p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") + p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) - pmid:28528849 + pmid:26041011 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) + act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) + act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) - - - pmid:28528849 - - p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS)) - + - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) + p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) - pmid:28528849 + pmid:25036637 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) - pmid:28528849 + pmid:25036637 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) - pmid:28528849 + pmid:25036637 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) - pmid:28528849 + pmid:25036637 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) + p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) + p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) + act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + + + + - pmid:28528849 + pmid:24457024 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) + complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") + bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) + bp(MESH:Proteolysis) association bp(HBP:Proteostasis) - pmid:28528849 + pmid:29311797 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) + bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) + bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis) + + + + + + - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) + complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cellular calcium ion homeostasis") + p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:28528849 + pmid:25036637 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) + a(MESH:Lysosomes) increases bp(MESH:Proteolysis) - pmid:28528849 + pmid:25784053 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:28528849 + pmid:24027553 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) + a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - pmid:29238289 - p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) + act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) - pmid:23702978 + pmid:25784053 - tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) + bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) - pmid:23702978 + pmid:25784053 - tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) + bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) - pmid:28528849 + pmid:25784053 - p(HGNC:DBN1) increases bp(GO:"synapse assembly") + p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1)) + + + + - pmid:28528849 + pmid:25784053 - act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") + complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) + + - pmid:28528849 + pmid:25784053 - act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") + act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph)) - pmid:23528736 + pmid:25784053 - p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) - - - pmid:23528736 + pmid:25784053 - p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) - pmid:23528736 + pmid:25784053 - p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") - pmid:23528736 + pmid:25784053 - p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) - pmid:23528736 + pmid:25784053 - p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin)) - pmid:23528736 + pmid:25784053 - p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:23528736 + pmid:25784053 - p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") + p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") - - - - - - - - - - - pmid:23528736 + pmid:25784053 - composite(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) + p(HGNC:PRSS1) decreases p(HGNC:ATF6) - pmid:14612456 + pmid:25784053 - p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") - pmid:14612456 + pmid:25784053 - p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) + p(HGNC:PRSS2) decreases p(HGNC:ATF6) - pmid:23528736 + pmid:25784053 - a(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) + p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") - pmid:23528736 + pmid:25784053 - a(CHEBI:"lithium atom") increases bp(GO:autophagy) + tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) - pmid:23528736 + pmid:25784053 - a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) + act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") - pmid:23528736 + pmid:25784053 - a(CHEBI:"lithium atom") decreases a(HP:"Neurofibrillary tangles") + act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) - pmid:30108137 + pmid:25784053 - r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) - pmid:30108137 + pmid:23702978 - p(MGI:Tfeb) increases p(MGI:Lamp1) + p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) + + - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) increases p(MGI:Ctsa) + act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) increases p(MGI:Ctsb) + p(HGNC:ATF4) increases p(HGNC:DDIT3) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) + p(HGNC:DDIT3) increases bp(GO:"apoptotic process") - pmid:30108137 + pmid:23702978 - p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) + p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") - pmid:30108137 + pmid:23702978 - p(MGI:Tfeb) increases a(HBP:"Tau fibrils") + p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) increases a(HBP:"Tau fibrils") + p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) + + - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) increases a(HBP:"Tau fibrils") + p(MGI:Atg5) decreases bp(HP:Neurodegeneration) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils")) + p(MGI:Atg7) decreases bp(HP:Neurodegeneration) - - - pmid:30108137 + pmid:24027553 - p(MGI:Tfeb) increases bp(MESH:Phagocytosis) + p(MGI:Atg7) decreases path(HBP:Neurodegeneration) - pmid:30108137 + pmid:24027553 - p(MGI:Tfeb) increases r(MGI:Lamp1) + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph)) - pmid:30108137 + pmid:24027553 - p(MGI:Tfeb) increases bp(MESH:Proteolysis) + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) - pmid:30108137 + pmid:24027553 - p(MGI:Tfeb) causesNoChange p(MGI:Phf1) + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - pmid:30108137 + pmid:24027553 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) + p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") - pmid:30108137 + pmid:29238289 - p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph)) + p(HGNC:RAB1A) association p(HGNC:MAPT) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) decreases p(MGI:Mapt) + p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine") - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) decreases path(MESH:Tauopathies) + p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) - pmid:30108137 + pmid:25784053 - p(MGI:Tfeb) decreases path(MESH:Gliosis) + p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) - pmid:30108137 + pmid:25784053 - bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes)) + p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) - pmid:25887395 + pmid:24027553 - p(HGNC:MAPT, frag("243_375")) increases a(HBP:"Tau fibrils") + p(HGNC:MAP1LC3A) positiveCorrelation path(MESH:"Plaque, Amyloid") - - - pmid:25887395 + pmid:25784053 - complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:chloroquine) decreases bp(GO:autophagy) - - - pmid:25887395 + pmid:25784053 - complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(HBP:"Tau aggregates") + a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine") - pmid:25887395 + pmid:25784053 - a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) - pmid:25887395 + pmid:25784053 - a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") + a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) - - - pmid:25887395 + pmid:24027553 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:chloroquine) increases p(HGNC:MAPT) - pmid:25887395 + pmid:24027553 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) - pmid:25887395 + pmid:25784053 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) - pmid:29988016 + pmid:21882945 - p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) - - - pmid:22817713 + pmid:21882945 - complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") + a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) - pmid:29988016 + pmid:25784053 - a(PUBCHEM:100984821) increases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) - pmid:21882945 + pmid:30116051 - p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) @@ -104255,7 +104915,7 @@

Statements

pmid:21882945 - a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) + a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90)) @@ -104264,61 +104924,61 @@

Statements

pmid:21882945 - a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) - pmid:26751493 + pmid:29311797 - a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:21882945 + pmid:21367866 - a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) - pmid:29191965 + pmid:30116051 - a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta") - pmid:29191965 + pmid:30116051 - a(HBP:"Phenylthiazolyl-hydrazide") positiveCorrelation bp(GO:locomotion) + a(CHEBI:tanespimycin) increases bp(GO:memory) - pmid:21882945 + pmid:30116051 - a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) - pmid:21882945 + pmid:30116051 - a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases a(HBP:HBP00016) @@ -104327,7 +104987,7 @@

Statements

pmid:21882945 - a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) @@ -104336,7 +104996,7 @@

Statements

pmid:21882945 - a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) @@ -104345,57 +105005,62 @@

Statements

pmid:21882945 - a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates") + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - pmid:21882945 + pmid:29311797 - a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:21882945 + pmid:25784053 - p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) + a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) - pmid:21882945 + pmid:25784053 - p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) - pmid:21882945 + pmid:30116051 - a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) + p(FPLX:mTORC1) increases bp(GO:macroautophagy) - pmid:21882945 + pmid:30116051 - a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) + p(FPLX:mTORC1) decreases bp(GO:macroautophagy) - + + + pmid:30116051 + + p(FPLX:mTORC1) decreases bp(GO:mitophagy) + @@ -104403,254 +105068,225 @@

Statements

- pmid:21882945 + pmid:30116051 - a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) + p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757)) - pmid:21882945 + pmid:30116051 - a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) - pmid:21882945 + pmid:30116051 - a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) + act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) - pmid:21882945 + pmid:30116051 - a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) - - - pmid:21882945 + pmid:30116051 - complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) + p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:21882945 + pmid:30116051 - p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90)) + p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") - - - - - pmid:21882945 + pmid:23528736 - a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + p(FPLX:mTORC1) decreases bp(GO:autophagy) - pmid:21882945 + pmid:23528736 - a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) + act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph)) - - - - - - - - - pmid:21882945 + pmid:23528736 - a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) + act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) - pmid:21882945 + pmid:30108137 - a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) + p(FPLX:mTORC1) increases p(MGI:Tfeb, pmod(Ph)) - - - - - pmid:21882945 + pmid:25784053 - a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) + a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) - pmid:21882945 + pmid:25784053 - a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) + a(PUBCHEM:10521421) increases bp(GO:autophagy) - - - - - pmid:21882945 + pmid:25784053 - a(CHEBI:celastrol) association act(p(FPLX:HSP90)) + a(CHEBI:fluphenazine) increases bp(GO:autophagy) - pmid:29311797 + pmid:25784053 - a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) + a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) - pmid:29311797 + pmid:25784053 - a(CHEBI:celastrol) decreases p(HGNC:MAPT) + a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) - pmid:21882945 + pmid:25784053 - bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers") + a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) - - - - - - - - - pmid:21882945 + pmid:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:799645) increases bp(GO:autophagy) - pmid:21882945 + pmid:25784053 - p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) + a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) - pmid:21882945 + pmid:25784053 - p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) + a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates") - pmid:21367866 + pmid:25784053 - act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) + a(PUBCHEM:877863) increases bp(GO:autophagy) - - - - - pmid:21882945 + pmid:25784053 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) - + + + pmid:25784053 + + a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") + - pmid:21882945 + pmid:25784053 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) + a(PUBCHEM:1560402) increases bp(GO:autophagy) - pmid:14963027 + pmid:25784053 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) + a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) - pmid:14963027 + pmid:25784053 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates") @@ -104659,7 +105295,12 @@

Statements

- + + + pmid:25784053 + + composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + @@ -104669,9 +105310,9 @@

Statements

- pmid:21882945 + pmid:25784053 - complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) @@ -104680,79 +105321,83 @@

Statements

- - - - - - - pmid:20071522 + pmid:25784053 - complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) + composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) - + + + pmid:25784053 + + a(PUBCHEM:675434) decreases p(HGNC:MAPT) + - pmid:20071522 + pmid:23528736 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) - pmid:20071522 + pmid:25784053 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(PUBCHEM:675434) decreases p(HGNC:TARDBP) - pmid:20071522 + pmid:25784053 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(PUBCHEM:675434) decreases p(HGNC:ATXN3) - + + + pmid:25784053 + + a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + - pmid:21882945 + pmid:23528736 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) + a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) - pmid:21882945 + pmid:25784053 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) - pmid:29311797 + pmid:23528736 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau aggregates") + a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) @@ -104763,93 +105408,90 @@

Statements

- pmid:21882945 + pmid:18930136 - complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") - - - - - pmid:21882945 + pmid:18930136 - complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + bp(GO:"antigen processing and presentation") association bp(GO:autophagy) - - - - - - - pmid:21882945 + pmid:18930136 - complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) + bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") - pmid:21882945 + pmid:18930136 - complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") + bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) - - - pmid:21882945 + pmid:18930136 - complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) + bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) - - - - - + + + pmid:18930136 + + bp(GO:pexophagy) isA bp(GO:macroautophagy) + - + + + pmid:18930136 + + bp(GO:reticulophagy) isA bp(GO:macroautophagy) + - pmid:21882945 + pmid:18930136 - complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) + bp(GO:xenophagy) isA bp(GO:macroautophagy) - - - + + + pmid:18930136 + + bp(GO:ribophagy) isA bp(GO:macroautophagy) + - pmid:21882945 + pmid:18930136 - complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + bp(GO:aggrephagy) isA bp(GO:macroautophagy) @@ -104860,9 +105502,9 @@

Statements

- pmid:21882945 + pmid:18930136 - complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + a(GO:phagophore) increases a(GO:autophagosome) @@ -104873,459 +105515,426 @@

Statements

- pmid:30126037 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) + composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) - pmid:29626319 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) + composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) - - - pmid:26195256 - - path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates") - + - pmid:29626319 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) + complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) - pmid:29626319 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) + complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) - pmid:29626319 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) + p(HGNC:ATG5) decreases path(HBP:Neurodegeneration) - - - pmid:29626319 - - path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") - + + + - pmid:29626319 + pmid:18930136 - path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") + complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) - - - pmid:24561250 - - path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") - + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association bp(GO:"cell cycle") + p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) - - - pmid:30126037 - - bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") - + - - - pmid:30126037 - - bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") - + + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") + composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) - - - pmid:30126037 - - bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") - + - - - pmid:30126037 - - bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") - + + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association p(MGI:Cdkn2a) + complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) - - - pmid:30126037 - - bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") - + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") + complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) - - - pmid:30126037 - - bp(GO:"cellular senescence") increases bp(GO:"neuron death") - + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") + p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) - - - pmid:30126037 - - bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") - + - - - pmid:30126037 - - bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) - + + + + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association path(MESH:Tauopathies) + complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") + complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) + + + + + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) + path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") + path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") + p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) + p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) + p(HGNC:ATP13A2, var("?")) increases path(HBP:Neurodegeneration) + + - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") association bp(GO:"inflammatory response") + p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") - pmid:30126037 + pmid:18930136 - bp(GO:"cellular senescence") increases bp(HBP:HBP00037) + a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") - pmid:29221819 + pmid:26631930 - bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) + act(a(MESH:Dyneins)) association p(HGNC:MAPT) - pmid:30126037 + pmid:18930136 - p(MGI:Cdkn2a) association bp(GO:"cellular senescence") + p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) + + - pmid:30126037 + pmid:8391280 - p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") + p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") - pmid:30126037 + pmid:8391280 - p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") + p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) - pmid:30126037 + pmid:8391280 - p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") + p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") - pmid:30126037 + pmid:18930136 - path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - pmid:30126037 + pmid:30116051 - path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - pmid:30126037 + pmid:29626319 - path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - pmid:23702978 + pmid:18930136 - p(HGNC:NFKB1) increases p(HGNC:IL1B) + a(CHEBI:"lithium(1+)") decreases path(HBP:Neurodegeneration) - pmid:27314526 + pmid:30116051 - p(HGNC:TLR4) increases bp(GO:"cytokine secretion") + a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) - pmid:30126037 + pmid:30116051 - bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") + a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) - pmid:30126037 + pmid:30116051 - p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") + a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) - pmid:30126037 + pmid:30116051 - p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") + a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) - pmid:30126037 + pmid:30116051 - p(MGI:Glb1) positiveCorrelation a(HP:brain) + a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) - pmid:30126037 + pmid:30116051 - a(HP:brain) positiveCorrelation p(MGI:Glb1) + a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) - pmid:30126037 + pmid:30116051 - bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") + a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") - pmid:30126037 + pmid:18930136 - path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) + bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) - pmid:30126037 + pmid:18930136 - path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") + a(GO:aggresome) negativeCorrelation bp(GO:"cell death") @@ -105336,872 +105945,881 @@

Statements

- pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(Ub)) - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + p(HGNC:HDAC6) regulates bp(GO:autophagy) - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + p(HGNC:HDAC6) increases bp(GO:autophagy) - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") + p(HGNC:HDAC6) regulates a(GO:aggresome) - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") + p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") + p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") + p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") - pmid:30126037 + pmid:18930136 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) + p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") - pmid:30126037 + pmid:28803412 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) + p(HGNC:HDAC6) decreases a(HBP:HBP00093) - pmid:30126037 + pmid:30640040 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) + p(HGNC:HDAC6) association a(PUBCHEM:53340666) - pmid:30126037 + pmid:29311797 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) + p(HGNC:HDAC6) increases act(p(HGNC:AIP)) - pmid:30126037 + pmid:29311797 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) + p(HGNC:HDAC6) association a(HBP:"Tau aggregates") - pmid:30126037 + pmid:26751493 - path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") + p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") - pmid:30126037 + pmid:26631930 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(Ac, Lys)) - pmid:30126037 + pmid:26751493 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") + p(HGNC:HDAC6) association a(HBP:"microtubule-binding region") - pmid:30126037 + pmid:25031639 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) + act(p(HGNC:HDAC6)) positiveCorrelation a(HBP:"Tau epitope, 12E8") - pmid:28408124 + pmid:24844691 - a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) + act(p(HGNC:HDAC6)) negativeCorrelation p(FPLX:Tubulin, pmod(Ac)) - pmid:28408124 + pmid:25546293 - a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNC:HDAC6)) negativeCorrelation p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) - pmid:28408124 + pmid:23487739 - a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) + act(p(HGNC:HDAC6)) negativeCorrelation a(GO:microtubule) - pmid:28408124 + pmid:23487739 - a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNC:HDAC6)) decreases p(INTERPRO:"Tubulin/FtsZ, GTPase domain", pmod(Ac)) - pmid:28408124 + pmid:28760828 - a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT) - pmid:28408124 + pmid:28760828 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:HDAC6) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) - pmid:28408124 + pmid:29844403 - a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) + act(p(HGNC:HDAC6)) positiveCorrelation act(p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:WDFY3) regulates bp(GO:autophagy) - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT) + p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:WDFY3) regulates a(GO:aggresome) - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) + tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") - pmid:28408124 + pmid:18930136 - a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) + bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:radical) association bp(GO:"detection of redox state") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) + a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:radical) regulates bp(MESH:Metabolism) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) + a(CHEBI:radical) decreases a(MESH:Antioxidants) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT) + a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:radical) increases bp(HBP:misfolding) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) + a(CHEBI:radical) increases bp(GO:"protein oxidation") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) + act(p(HGNC:XDH)) increases a(CHEBI:radical) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:XDH)) increases a(CHEBI:"reactive nitrogen species") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) + act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) + act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive nitrogen species") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive oxygen species") - pmid:28408124 + pmid:24563850 - a(HBP:"Tau antibody, Tau46") association p(HGNC:MAPT) + act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive nitrogen species") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + bp(GO:"response to radiation") increases a(CHEBI:radical) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + a(MESH:"Air Pollution") increases a(CHEBI:radical) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + bp(GO:"detection of redox state") association a(CHEBI:radical) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) + bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) + bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) + p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + p(HGNC:EIF2A) association p(HGNC:HSPB8) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) - - - pmid:25331948 - - a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) - + + + - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) + + + + + + - pmid:25331948 + pmid:29626319 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) + + + + - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") + act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) - pmid:25331948 + pmid:29121589 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) - pmid:25331948 + pmid:29121589 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27") + + + + - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(Ph)) + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) + bp(GO:"protein oxidation") association bp(GO:aging) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) + bp(GO:"protein oxidation") association path(MESH:Neoplasms) - pmid:25331948 + pmid:29024336 - a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") + bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") - pmid:25331948 + pmid:26195256 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Cardiovascular Diseases") association path(MESH:"Alzheimer Disease") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") - pmid:25331948 + pmid:24563850 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(HBP:misfolding) - pmid:29221819 + pmid:24563850 - p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") - pmid:25331948 + pmid:24563850 - p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk) + act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") + + + + + + - pmid:26095350 + pmid:25036637 - p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") + p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) - pmid:28877763 + pmid:25036637 - p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) + p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) - pmid:25331948 + pmid:21882945 - p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:28877763 + pmid:21882945 - p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") - pmid:25331948 + pmid:21882945 - p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) - pmid:25331948 + pmid:21882945 - complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) + p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) - - - - - pmid:25331948 + pmid:21882945 - composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") - - - - - pmid:25331948 + pmid:21882945 - composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) + p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:25331948 + pmid:21882945 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) + act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) - pmid:25331948 + pmid:21882945 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) + act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) - pmid:25331948 + pmid:18500754 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) + p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) - pmid:25331948 + pmid:25036637 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) + p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") - pmid:25331948 + pmid:29844403 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) + act(p(INTERPRO:"Heat shock protein Hsp90 family")) positiveCorrelation act(p(HGNC:HDAC6)) - pmid:25331948 + pmid:25036637 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) + p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) @@ -106210,680 +106828,551 @@

Statements

- - - pmid:25331948 - - composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) - + - - - pmid:25331948 - - composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) - + - - - pmid:25331948 - - act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) - + + + - pmid:25331948 + pmid:25036637 - p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:25331948 - - p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) - + + + - pmid:25331948 + pmid:25036637 - p(HGNC:SYK) increases a(CHEBI:"amyloid-beta") + p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:25331948 - - act(p(HGNC:SYK)) increases a(CHEBI:"amyloid-beta") - + + + - pmid:25331948 + pmid:25036637 - act(p(HGNC:SYK)) decreases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:25331948 - - act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta")) - + + + - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) regulates p(HBP:"sAPP-beta") + p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:25331948 - - act(p(HGNC:SYK)) increases r(HGNC:BACE1) - + - - - pmid:25331948 - - act(p(HGNC:SYK)) increases p(HGNC:BACE1) - + + + - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) regulates p(HGNC:BACE1) + p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:25331948 + pmid:25036637 - act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(Ph)) + p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) - - - pmid:25331948 - - p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + - - - pmid:28877763 - - p(HGNC:SYK) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + - - - pmid:28877763 - - act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) - - - pmid:28877763 - - p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) - - - pmid:26631930 - - p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + + + - pmid:25331948 + pmid:25036637 - act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) + p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) increases act(p(HGNC:GSK3B)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) - pmid:25331948 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) - pmid:25331948 + pmid:25036637 - p(HGNC:SYK) decreases act(p(FPLX:PKA)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) - pmid:25331948 + pmid:25036637 - p(HGNC:SYK) decreases act(p(FPLX:PKA)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) - pmid:25331948 + pmid:25036637 - p(HGNC:SYK) increases p(FPLX:PKA, pmod(Ph, Tyr, 330)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) - pmid:29191965 + pmid:25036637 - p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation bp(GO:"microglial cell activation") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) association a(HBP:"Tau aggregates") + p(HGNC:FKBP5) association p(HGNC:CDC37) - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) association a(HBP:"Tau aggregates") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) positiveCorrelation a(HBP:"Tau aggregates") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:FKBP5) association p(HGNC:EGLN1) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + p(HGNC:FKBP5) association p(HGNC:PDCD2) - pmid:28877763 + pmid:25036637 - p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + p(HGNC:FKBP5) association p(HGNC:ANKMY2) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded)) + p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) - pmid:28877763 + pmid:25036637 - act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:misfolded)) + p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") - pmid:28877763 + pmid:21882945 - p(HGNC:SYK) increases p(HGNC:MAPT) + p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:28877763 + pmid:21882945 - p(HGNC:SYK) causesNoChange r(HGNC:MAPT) + p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) - - - pmid:26501932 + pmid:20071522 - p(HGNC:SYK) partOf a(HBP:pretangles) + p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) - pmid:26501932 + pmid:21882945 - p(HGNC:SYK) partOf a(HBP:"GVD bodies") + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - pmid:25331948 + pmid:20071522 - act(p(HGNC:SYK)) negativeCorrelation p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - pmid:23702978 + pmid:21882945 - act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) + p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) - pmid:25331948 + pmid:21882945 - act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) + p(HGNC:FKBP5) increases p(HGNC:MAPT) - pmid:25331948 + pmid:20071522 - a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) + p(HGNC:FKBP5) increases p(HGNC:MAPT) - pmid:25331948 + pmid:21882945 - a(PUBCHEM:71656932) causesNoChange a(CHEBI:"amyloid-beta") + p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph)) - pmid:25331948 + pmid:29311797 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + p(HGNC:FKBP5) isA a(MESH:Immunophilins) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta") + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta")) + p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) - pmid:25331948 + pmid:20071522 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) + p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") - + - pmid:25331948 + pmid:29686391 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Tyr, 18)) + p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(Ph, Tyr, 231)) - + + + - pmid:25331948 + pmid:26631930 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(Ph, Tyr, 231)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(Ph, Ser, 473)) - + - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(Ph)) - + @@ -106891,326 +107380,293 @@

Statements

- - - pmid:28877763 - - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK) - + - - - pmid:28877763 - - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK)) - + - - - pmid:28877763 - - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) - + - - - pmid:26751493 - - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") - + - pmid:26631930 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:26631930 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) association a(HBP:"paired helical filaments") + p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:28877763 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) + p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") - - - pmid:28877763 - - p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) - + - pmid:25331948 + pmid:25036637 - p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) + p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") - - - pmid:25331948 - - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) - + - - - pmid:24183963 - - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) - + - pmid:29121589 + pmid:25036637 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) + bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) - pmid:29844403 + pmid:25036637 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) + bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) - pmid:21734277 + pmid:25036637 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) + p(HGNC:EGLN1) association p(HGNC:FKBP5) - pmid:25331948 + pmid:25036637 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) negativeCorrelation act(p(HGNC:SYK)) + p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") - pmid:29121589 + pmid:25036637 - p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) - pmid:29121589 + pmid:25036637 - p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:25331948 + pmid:25036637 - p(FPLX:PKA, pmod(Ph, Tyr, 330)) decreases act(p(FPLX:PKA)) + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) positiveCorrelation p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) positiveCorrelation p(HGNC:APP) + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:22419736 - - act(p(HGNC:AK1)) association a(CHEBI:"amyloid-beta polypeptide 42") - + - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 202))) + p(HGNC:PDCD2) association p(HGNC:FKBP5) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 396))) + p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") - - - pmid:22419736 - - p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 404))) - + - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 231))) + p(HGNC:ANKMY2) association p(HGNC:FKBP5) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 235))) + p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") + + + + + + + + + + + + - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) increases p(HBP:"Tau aggregates") + p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) regulates p(ECCODE:"2.7.11.31") + p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) regulates p(HGNC:GSK3B) + p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") + p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") + p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:AK1) increases act(p(HGNC:MAPT)) + p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) - pmid:22419736 + pmid:25036637 - p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(HGNC:AK1) + p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) @@ -107227,1060 +107683,848 @@

Statements

- - - pmid:22419736 - - act(p(ECCODE:"2.7.11.31")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) - + - - - pmid:22419736 - - p(ECCODE:"2.7.11.31") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) - + - - - pmid:22419736 - - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - + - - - pmid:22419736 - - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - + - - - pmid:22419736 - - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) - + - - - pmid:22419736 - - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) - + - pmid:22419736 + pmid:23702978 - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) + bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) - pmid:22419736 + pmid:25036637 - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) + p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) - pmid:22419736 + pmid:25036637 - p(ECCODE:"2.7.11.31") decreases act(p(HGNC:GSK3B)) + p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") - pmid:22419736 + pmid:29311797 - p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph)) + p(HGNC:FKBP8) isA a(MESH:Immunophilins) - - - pmid:22419736 - - p(HBP:"AK1 R132A") causesNoChange p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) - - - pmid:22419736 + pmid:25036637 - a(HBP:acadesine) increases act(p(ECCODE:"2.7.11.31")) + p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") - pmid:22419736 + pmid:25036637 - path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") - pmid:30640040 + pmid:25036637 - act(p(HGNC:FLT1)) increases a(HBP:"Tau aggregates") + bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) - pmid:30640040 + pmid:25036637 - act(p(HGNC:KDR)) increases a(HBP:"Tau aggregates") + p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) - pmid:30640040 + pmid:25036637 - p(HGNC:KDR) association a(PUBCHEM:11154925) + p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) - pmid:30640040 + pmid:29311797 - p(HGNC:KDR) association a(PUBCHEM:11234052) + p(HGNC:FKBP6) isA a(MESH:Immunophilins) - - - pmid:30640040 - - act(p(FPLX:TGFB)) increases a(HBP:"Tau aggregates") - + - pmid:30640040 + pmid:25036637 - act(p(FPLX:HDAC)) decreases a(HBP:"Tau aggregates") + a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) - pmid:30640040 + pmid:25036637 - p(FPLX:HDAC) association a(PUBCHEM:9865515) + p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) - - - pmid:21427723 - - act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) + p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9804992) increases a(HBP:"Tau aggregates") + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) - pmid:30640040 + pmid:21882945 - a(PUBCHEM:9865515) increases a(HBP:"Tau aggregates") + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") - - - pmid:30640040 - - a(PUBCHEM:9865515) association p(FPLX:HDAC) - + - - - pmid:30640040 - - a(PUBCHEM:4261) increases a(HBP:"Tau aggregates") - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:4261) association p(HGNC:HDAC1) + p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:4261) association p(HGNC:HDAC3) + p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) - - - pmid:30640040 - - a(PUBCHEM:24756910) increases a(HBP:"Tau aggregates") - + - - - pmid:30640040 - - a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:24756910) association p(HGNC:EGFR) + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:24756910) association p(HGNC:ERBB2) + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:448537) increases a(HBP:"Tau aggregates") + p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body") - - - pmid:30640040 - - a(PUBCHEM:448537) association p(FPLX:ESR) - - - pmid:30640040 + pmid:25036637 - a(PUBCHEM:5318517) increases a(HBP:"Tau aggregates") + p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:5318517) association p(FPLX:NFkappaB) + p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) - - - pmid:30640040 - - a(PUBCHEM:5318517) association p(FPLX:Actin) - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:71295844) increases a(HBP:"Tau aggregates") + p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:71295844) association p(HGNC:GSK3A) + p(HGNC:DCP1A) association bp(GO:"gene silencing") - - - pmid:30640040 - - a(PUBCHEM:71295844) association p(HGNC:GSK3B) - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:42640) increases a(HBP:"Tau aggregates") + p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:42640) association p(HGNC:MDM4) + p(HGNC:EDC3) association bp(GO:"gene silencing") - - - pmid:30640040 - - a(PUBCHEM:2746) increases a(HBP:"Tau aggregates") - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:2746) association p(FPLX:"HDAC_I") + p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:71729974) increases a(HBP:"Tau aggregates") + p(HGNC:DDX6) association bp(GO:"gene silencing") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") + complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:53340666) increases a(HBP:"Tau aggregates") + complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala")) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:53340666) association p(HGNC:HDAC6) + complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11154925) decreases a(HBP:"Tau aggregates") + p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11154925) association p(HGNC:KDR) + p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body") - pmid:30640040 + pmid:25036637 - a(PUBCHEM:4521392) decreases a(HBP:"Tau aggregates") + p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body") - - - pmid:30640040 - - a(PUBCHEM:4521392) association p(HGNC:TGFBR1) - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11234052) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11234052) association p(HGNC:KDR) + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:46209426) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:46209426) association p(FPLX:ROCK) + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:6321424) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11570805) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11570805) association p(HGNC:MAPK14) + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:156422) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:156422) association p(HGNC:MAPK14) + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9880) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9880) decreases act(p(HGNC:AR)) + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:3033825) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:3033825) association p(HGNC:TNC) + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:5311272) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) + a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:49806720) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) + a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) - - - pmid:30640040 - - a(PUBCHEM:9839311) decreases a(HBP:"Tau aggregates") - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9839311) association p(HGNC:SELE) + p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:9839311) association p(HGNC:ICAM1) + p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:447966) decreases a(HBP:"Tau aggregates") + p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) - - - pmid:30640040 - - a(PUBCHEM:447966) association p(HGNC:TGFBR1) - + - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11655119) decreases a(HBP:"Tau aggregates") + p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) - pmid:30640040 + pmid:25036637 - a(PUBCHEM:11655119) association p(HGNC:TGFBR1) + p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) - - - pmid:30640040 - - a(PUBCHEM:11655119) association p(HGNC:TGFBR2) - + - pmid:30640040 + pmid:29311797 - a(PUBCHEM:10435235) decreases a(HBP:"Tau aggregates") + p(HGNC:FKBP4) isA a(MESH:Immunophilins) - pmid:30640040 + pmid:29311797 - a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) + p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") - pmid:30640040 + pmid:26631930 - a(PUBCHEM:5833) decreases a(HBP:"Tau aggregates") + p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") - - - pmid:30640040 - - a(PUBCHEM:5833) association p(HGNC:AR) - - - pmid:30640040 + pmid:26903089 - a(PUBCHEM:10341154) decreases a(HBP:"Tau aggregates") + act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") - - - pmid:30640040 - - a(PUBCHEM:10341154) association p(HGNC:MAPK14) - + - - - pmid:30640040 - - a(PUBCHEM:4878) decreases a(HBP:"Tau aggregates") - + - - - pmid:30640040 - - a(PUBCHEM:4878) association p(HGNC:LCK) - + - - - pmid:30640040 - - a(PUBCHEM:4878) association p(HGNC:FYN) - + - - - pmid:30640040 - - p(HGNC:HDAC1) association a(PUBCHEM:4261) - + - - - pmid:30640040 - - p(HGNC:HDAC3) association a(PUBCHEM:4261) - + - - - pmid:28771976 - - p(HGNC:HDAC3) increases act(a(CL:0000129)) - + - - - pmid:28771976 - - p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") - + - - - pmid:28771976 - - p(HGNC:HDAC3) decreases a(GO:"dendritic spine") - + - - - pmid:30640040 - - p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) - + - - - pmid:30640040 - - p(FPLX:"HDAC_I") association a(PUBCHEM:2746) - + - - - pmid:30640040 - - p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) - + - - - pmid:30640040 - - p(HGNC:ERBB2) association a(PUBCHEM:24756910) - + - - - pmid:30640040 - - p(FPLX:ESR) association a(PUBCHEM:448537) - + - pmid:30640040 + pmid:21882945 - p(FPLX:Actin) association a(PUBCHEM:5318517) + p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) - pmid:22033876 + pmid:21882945 - act(p(FPLX:Actin)) association a(HBP:"proline-rich domain") + p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph))) - pmid:30640040 + pmid:21882945 - p(HGNC:GSK3A) association a(PUBCHEM:71295844) + p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) - pmid:22817713 + pmid:21882945 - p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") - pmid:30640040 + pmid:21882945 - p(HGNC:MDM4) association a(PUBCHEM:42640) + p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) - - - pmid:30640040 - - p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) - + + + - pmid:30640040 + pmid:25036637 - p(HGNC:TGFBR1) association a(PUBCHEM:4521392) + p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) - pmid:30640040 + pmid:25036637 - p(HGNC:TGFBR1) association a(PUBCHEM:447966) + p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) - - - pmid:30640040 - - p(HGNC:TGFBR1) association a(PUBCHEM:11655119) - + - pmid:30640040 + pmid:25036637 - p(FPLX:ROCK) association a(PUBCHEM:46209426) + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) - pmid:30640040 + pmid:25036637 - p(HGNC:TNC) association a(PUBCHEM:3033825) + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) - pmid:30640040 + pmid:25036637 - p(HGNC:SELE) association a(PUBCHEM:9839311) + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) - pmid:30640040 + pmid:25036637 - p(HGNC:ICAM1) association a(PUBCHEM:9839311) + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) - - - pmid:30640040 - - p(HGNC:TGFBR2) association a(PUBCHEM:11655119) - + - - - pmid:30640040 - - p(HGNC:LCK) association a(PUBCHEM:4878) - + - - - pmid:29191965 - - p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - + + + - pmid:26751493 + pmid:25036637 - p(HGNC:LCK) association p(HBP:"projection domain") + p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) - pmid:26631930 + pmid:25036637 - p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) - - - pmid:26751493 - - p(HGNC:LCK) association a(HBP:"projection domain") - + @@ -108290,9 +108534,9 @@

Statements

- pmid:29191965 + pmid:25036637 - composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) + p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) @@ -108305,12 +108549,7 @@

Statements

- - - pmid:29191965 - - bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") - + @@ -108318,12 +108557,7 @@

Statements

- - - pmid:29191965 - - composite(p(HGNC:MAPT), p(HGNC:SPTB)) regulates a(GO:"microtubule cytoskeleton") - + @@ -108331,156 +108565,101 @@

Statements

- - - pmid:29191965 - - complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") - + - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) - pmid:29191965 + pmid:25036637 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(HBP:Neurodegeneration) + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) - + - - - pmid:29191965 - - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") - + - - - pmid:29191965 - - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases bp(GO:locomotion) - + - - - pmid:29191965 - - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") - + @@ -108488,65 +108667,48 @@

Statements

- - - pmid:29191965 - - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) - + - - - pmid:29191965 - - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") - + - - - pmid:29191965 - - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") - + - - - pmid:29191965 - - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) - + - - - pmid:29191965 - - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") - + + + + + - pmid:25374103 + pmid:21882945 - p(HBP:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) + + + + - pmid:25374103 + pmid:21882945 - p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) @@ -108555,275 +108717,237 @@

Statements

pmid:25374103 - p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) - - - pmid:26751493 - - p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") - + - - - pmid:26631930 - - p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") - + - - - pmid:26751493 - - p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") - + - pmid:26751493 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) - pmid:26631930 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) - pmid:26631930 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) - pmid:26631930 + pmid:25036637 - p(HBP:"4R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"4R tau")) + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") isA p(HGNC:MAPT) + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") partOf a(HBP:pretangles) + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle") + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") + p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") + p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") + p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") partOf complex(GO:"neuronal cell body") + p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") partOf complex(GO:dendrite) + p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) - pmid:23407988 + pmid:25036637 - p(HBP:"4R tau") partOf a(MESH:Neuropil) + p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) - - - pmid:28775333 - - p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) - + - - - pmid:21427723 - - p(HBP:"4R tau") partOf path(HBP:"4R tauopathy") - + - - - pmid:27574109 - - p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain") - + - - - pmid:29191965 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) - + - - - pmid:29191965 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) - + - - - pmid:29191965 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) negativeCorrelation bp(GO:"cell aging") - + - - - pmid:29191965 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) - + - - - pmid:29191965 - - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") - + - - - pmid:29191965 - - bp(GO:"cell aging") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) - + - - - pmid:29191965 - - complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) - + - - - pmid:29191965 - - complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -108833,9 +108957,9 @@

Statements

- pmid:29191965 + pmid:25036637 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) + p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) @@ -108846,36 +108970,40 @@

Statements

- pmid:29191965 + pmid:25036637 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) + a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) - pmid:29191965 + pmid:25036637 - p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") + a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) + + + + - pmid:29191965 + pmid:21882945 - a(GO:"cell body") association p(HGNC:MAPT) + p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:29191965 + pmid:29311797 - p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) @@ -108884,187 +109012,231 @@

Statements

pmid:26631930 - p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + + + + - pmid:29191965 + pmid:21882945 - p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) - pmid:26631930 + pmid:29311797 - p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:29191965 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:26751493 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PTGES3) increases p(HGNC:MAPT) - pmid:26751493 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates") + p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph)) - pmid:26631930 + pmid:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?")) + p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") - pmid:22817713 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") + p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") - pmid:26671985 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) - pmid:26671985 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction") + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) - pmid:17078951 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA) + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + + + + - pmid:18239272 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle") + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) - pmid:18239272 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads") + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) - pmid:18239272 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid") + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) - pmid:18239272 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) - pmid:11943212 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422") + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + + + + + + + + + + + + - pmid:26118667 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) negativeCorrelation m(MIRBASE:"rno-mir-195") + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) - pmid:23294633 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) - pmid:27373205 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain") + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) - pmid:27373205 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers") + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + + + + + + + + + + + + + + + + + + + + + + + + - pmid:27373205 + pmid:25036637 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport") + p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) @@ -109075,63 +109247,71 @@

Statements

- pmid:29191965 + pmid:25036637 - composite(p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")), p(HGNC:CDK5)) decreases a(MESH:Neurons) + p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) - pmid:29191965 + pmid:25036637 - a(PUBCHEM:6475963) decreases a(HBP:"Tau aggregates") + p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) + + + + + + + + - pmid:29191965 + pmid:25036637 - a(PUBCHEM:6475963) positiveCorrelation bp(GO:locomotion) + a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") - pmid:29191965 + pmid:24706768 - a(PUBCHEM:66766582) decreases path(HBP:Neurodegeneration) + a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) - pmid:29191965 + pmid:24706768 - a(CHEBI:azaperone) increases bp(GO:locomotion) + a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis) - pmid:29191965 + pmid:24706768 - a(CHEBI:azaperone) decreases p(HGNC:MAPT) + a(HBP:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:29191965 + pmid:24706768 - a(CHEBI:azaperone) decreases path(HBP:Neurodegeneration) + p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") @@ -109142,378 +109322,369 @@

Statements

- pmid:29191965 + pmid:24706768 - composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(MESH:Longevity) + complex(a(HBP:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") - pmid:29191965 + pmid:28803412 - composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(GO:locomotion) + p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") - pmid:29191965 + pmid:28803412 - composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) positiveCorrelation bp(GO:"insulin receptor signaling pathway") + p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") - pmid:29191965 + pmid:28803412 - p(HGNC:WNT2) association path(MESH:Tauopathies) + p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") - pmid:29191965 + pmid:28803412 - p(HGNC:TTBK2) association path(MESH:Tauopathies) + p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") - pmid:17620722 + pmid:28803412 - p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) + a(HBP:HBP00016) increases path(MESH:"Parkinson Disease") - pmid:17620722 + pmid:27075649 - p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210)) + a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease") - - - - - - - pmid:25673844 + pmid:27075649 - p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily") + a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy") - pmid:25673844 + pmid:27075649 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease") - pmid:25673844 + pmid:30116051 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + a(HBP:HBP00016) decreases complex(GO:"proteasome complex") - pmid:25673844 + pmid:28803412 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + a(HBP:HBP00093) increases path(MESH:"Parkinson Disease") - pmid:25673844 + pmid:28803412 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease") - pmid:25673844 + pmid:28803412 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:25673844 + pmid:28803412 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + a(HBP:HBP00093) increases a(HBP:HBP00092) - pmid:25473830 + pmid:27075649 - p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) + a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) - pmid:25473830 + pmid:28803412 - p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + a(HBP:HBP00093) increases bp(GO:"apoptotic process") - pmid:27607061 + pmid:28803412 - p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2)) + a(HBP:HBP00093) increases bp(GO:"apoptotic process") - pmid:26323690 + pmid:27075649 - p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph)) + a(HBP:HBP00093) increases bp(GO:"apoptotic process") - pmid:26323690 + pmid:28803412 - p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) + a(HBP:HBP00093) decreases a(MESH:Mitochondria) - pmid:26323690 + pmid:28803412 - p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) + a(HBP:HBP00093) increases bp(HBP:HBP00037) - pmid:26323690 + pmid:28803412 - p(HGNC:TTBK2) association p(HGNC:CEP164) + a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress") - pmid:26323690 + pmid:28803412 - act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164) + a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex")) - pmid:26323690 + pmid:28803412 - p(HGNC:TTBK2) association p(HGNC:MAPRE1) + a(HBP:HBP00093) increases bp(GO:"microglial cell activation") - pmid:26323690 + pmid:28803412 - act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110) + a(HBP:HBP00093) increases bp(GO:"inflammatory response") - pmid:26323690 + pmid:28803412 - act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) + a(HBP:HBP00093) increases act(p(HGNC:TLR2)) - pmid:26323690 + pmid:28803412 - act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) + a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species") - pmid:29191965 + pmid:28803412 - p(HGNC:TAOK1) association path(MESH:Tauopathies) + a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") - pmid:25974414 + pmid:28803412 - act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) + a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) - pmid:29191965 + pmid:27075649 - p(HGNC:CTSE) association path(MESH:Tauopathies) + a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)") - pmid:29191965 + pmid:28803412 - p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) + a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport") - - - - - - - - - pmid:29191965 + pmid:28803412 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) + a(HBP:HBP00093) decreases bp(GO:"axonal transport") - + + + pmid:28803412 + + a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + - pmid:29191965 + pmid:28803412 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) decreases bp(GO:locomotion) + a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus") - pmid:29191965 + pmid:28803412 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases path(HBP:Neurodegeneration) + a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") - pmid:29191965 + pmid:27075649 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases p(HGNC:MAPT) + a(HBP:HBP00092) increases bp(GO:"apoptotic process") - pmid:29191965 + pmid:28803412 - p(HGNC:ZC3H14) increases path(MESH:Tauopathies) + a(HBP:HBP00092) increases bp(GO:"inflammatory response") - pmid:29191965 + pmid:28803412 - p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") + a(HBP:HBP00092) increases bp(GO:"microglial cell activation") - pmid:29191965 + pmid:27075649 - bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") + a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") - pmid:29191965 + pmid:27075649 - bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(HBP:misfolding)) + a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) - pmid:29191965 + pmid:27075649 - p(HGNC:DDC) increases a(CHEBI:dopamine) + a(HBP:HBP00092) increases a(HBP:HBP00016) - pmid:29191965 + pmid:28803412 - p(HGNC:DDC) increases a(CHEBI:serotonin) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") @@ -109524,76 +109695,72 @@

Statements

- pmid:29191965 + pmid:24113872 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) + p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:29191965 + pmid:24113872 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) + act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) - pmid:29191965 + pmid:24113872 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) - pmid:29191965 + pmid:24113872 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(HBP:Neurodegeneration) + act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) - - - - - pmid:29191965 + pmid:24113872 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) + act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") - pmid:29191965 + pmid:24113872 - p(HGNC:GCH1) regulates a(CHEBI:dopamine) + act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") - pmid:29191965 + pmid:28803412 - p(HGNC:GCH1) regulates a(CHEBI:serotonin) + a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") - pmid:29191965 + pmid:28803412 - p(HGNC:GCH1) regulates act(p(HGNC:DDC)) + a(CHEBI:salubrinal) decreases a(HBP:HBP00093) @@ -109604,921 +109771,859 @@

Statements

- pmid:29191965 + pmid:28803412 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) + complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") + + + + - pmid:29191965 + pmid:26631930 - p(HGNC:TPH1) regulates a(CHEBI:dopamine) + act(a(MESH:Kinesin)) association p(HGNC:MAPT) - pmid:29191965 + pmid:28803412 - p(HGNC:TPH1) regulates a(CHEBI:serotonin) + p(HGNC:USP19) increases sec(p(HGNC:SNCA)) - pmid:29191965 + pmid:28803412 - p(HGNC:TPH1) regulates act(p(HGNC:DDC)) + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) - - - - - pmid:29191965 + pmid:28803412 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) - pmid:29686391 + pmid:28803412 - a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) - pmid:29686391 + pmid:29626319 - tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils") + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:29686391 + pmid:29626319 - g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") + a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) - pmid:29686391 + pmid:29626319 - g(HGNC:TP53) decreases bp(GO:"cell proliferation") + a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) - pmid:29686391 + pmid:28775333 - bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) - pmid:29686391 + pmid:28775333 - bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") - pmid:29686391 + pmid:28775333 - p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) - pmid:29686391 + pmid:28775333 - a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) - pmid:29686391 + pmid:28803412 - a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) + a(HBP:HBP00094) decreases a(HBP:HBP00016) - pmid:29686391 + pmid:28803412 - a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) + a(HBP:HBP00094) decreases bp(GO:"apoptotic process") - pmid:29686391 + pmid:27075649 - p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016) - pmid:29686391 + pmid:27075649 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(HBP:HBP00095) increases bp(GO:"neuron death") - pmid:29686391 + pmid:27075649 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(HBP:HBP00095) decreases bp(GO:"ion homeostasis") - pmid:29686391 + pmid:27075649 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(HBP:HBP00095) increases a(HBP:HBP00016) - pmid:29686391 + pmid:27075649 - bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) + a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093) - pmid:29686391 + pmid:29807032 - bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) + act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") - pmid:29686391 + pmid:29807032 - p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) - pmid:29686391 + pmid:29807032 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + path(MESH:"Stress Disorders, Traumatic") increases p(MESH:"corticotropin releasing factor-binding protein") - pmid:29686391 + pmid:23211705 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) decreases a(MESH:Estradiol) - pmid:29686391 + pmid:23211705 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) regulates p(HGNC:CGB3) - pmid:29686391 + pmid:23211705 - p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin") + p(MGI:Crh) decreases p(HGNC:CGB3) - pmid:29686391 + pmid:23211705 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) causesNoChange a(MESH:Progesterone) - pmid:29686391 + pmid:23211705 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) decreases a(MESH:Progesterone) - pmid:29686391 + pmid:23211705 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) decreases a(MESH:Progesterone) - pmid:29686391 + pmid:25125464 - a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) + p(MGI:Crh) increases p(HBP:"Tau epitope, AT8") - pmid:29686391 + pmid:25125464 - a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) increases a(HBP:"Tau epitope, PHF1") - pmid:29686391 + pmid:25125464 - a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 262)) - pmid:29686391 + pmid:25125464 - a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(MGI:Crh) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 422)) - - - - - - - - - pmid:29686391 + pmid:8940412 - a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") - - - pmid:29686391 + pmid:8940412 - complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") + act(p(RGD:Crh)) regulates sec(p(RGD:Pomc)) - - - pmid:29686391 + pmid:8940412 - a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) - pmid:29686391 + pmid:8940412 - a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) - pmid:29686391 + pmid:8940412 - a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) - pmid:29686391 + pmid:8940412 - a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") - pmid:29686391 + pmid:8940412 - p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:antalarmin) decreases sec(p(RGD:Pomc)) - pmid:29686391 + pmid:30145931 - p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) - pmid:29686391 + pmid:30145931 - p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin") + a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) - pmid:29686391 + pmid:23528736 - p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) - pmid:29686391 + pmid:30145931 - p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:epoxomicin) increases bp(GO:"protein ubiquitination") - pmid:29686391 + pmid:30145931 - p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin") + a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:28877763 + pmid:30145931 - p(HGNC:MAPT, pmod(HBP:misfolded)) positiveCorrelation act(p(HGNC:SYK)) + a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) - - - - - pmid:25374103 + pmid:30145931 - composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") + a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:25374103 + pmid:30145931 - p(MGI:Stub1) decreases act(p(MGI:Casp3)) + a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:25374103 + pmid:30145931 - p(MGI:Stub1) decreases p(HBP:"Tau C3") + a(CHEBI:epoxomicin) decreases a(MESH:"Dendritic Spines") - - - - - - - pmid:25374103 + pmid:24027553 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau isoform F (441 aa)") + a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) - - - pmid:25374103 + pmid:24027553 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") + a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) - pmid:25374103 + pmid:24027553 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + a(CHEBI:epoxomicin) increases p(HGNC:MAPT) - pmid:25374103 + pmid:23528736 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") + a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) - pmid:25374103 + pmid:30145931 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers") - pmid:25374103 + pmid:30145931 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) - - - pmid:25374103 + pmid:30145931 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) - - - pmid:25374103 + pmid:29215007 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:25374103 + pmid:29215007 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly") - pmid:25374103 + pmid:26751493 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25374103 + pmid:17493042 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - - - pmid:25374103 + pmid:17493042 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) + p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:25374103 + pmid:21367866 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37) - - - pmid:25374103 + pmid:22156579 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) - pmid:25374103 + pmid:22156579 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf a(HBP:"Tau epitope, 12E8") - pmid:25374103 + pmid:22833681 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - pmid:25374103 + pmid:30145931 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers") - pmid:25374103 + pmid:28784767 - a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") - - - - - - - - - - - pmid:25374103 + pmid:18239272 - complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") - - - - - - - pmid:25374103 + pmid:24760868 - p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) - - - - - - - - - - - - - - - - - pmid:25374103 + pmid:29191965 - complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"Tau isoform F (441 aa)") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25374103 + pmid:22817713 - complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"4R tau", var("p.Lys280del")) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates") - - - - - pmid:25374103 + pmid:22817713 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers") - pmid:25374103 + pmid:22486774 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers") - pmid:25374103 + pmid:14612456 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph)) - pmid:25374103 + pmid:17078951 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3") + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA) - pmid:25374103 + pmid:26118667 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del")) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) negativeCorrelation m(MIRBASE:"rno-mir-195") - pmid:25374103 + pmid:22833681 - bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del")) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) - pmid:25374103 + pmid:24406748 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) - pmid:25374103 + pmid:23294633 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:25374103 + pmid:22253473 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) + p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle") - pmid:25374103 + pmid:30145931 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) + a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) - pmid:25374103 + pmid:30145931 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) + a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:25374103 + pmid:29626319 - bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) + a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) - pmid:28420982 + pmid:29626319 - a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") + a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") - pmid:28420982 + pmid:26692334 - bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) + a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) - - - - - pmid:28420982 + pmid:26692334 - a(MESH:Exosomes) association sec(p(HGNC:MAPT)) + a(CHEBI:rolipram) positiveCorrelation act(p(FPLX:PKA)) - pmid:29238289 + pmid:26692334 - act(a(MESH:Exosomes)) association p(HGNC:MAPT) + a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) - pmid:28420982 + pmid:26692334 - a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") + a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates") - pmid:28420982 + pmid:30145931 - a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181)) + a(CHEBI:cycloheximide) decreases bp(GO:translation) - pmid:28420982 + pmid:30145931 - a(GO:microvesicle) association sec(p(HGNC:MAPT)) + a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:28420982 + pmid:23702978 - a(GO:microvesicle) regulates sec(p(HGNC:MAPT)) + a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") - + + + pmid:30145931 + + a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) + - pmid:28420982 + pmid:30145931 - complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT)) + a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) - + + + pmid:22072628 + + p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + - pmid:28420982 + pmid:26996941 - complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1)) @@ -110527,32 +110632,15 @@

Statements

- - - pmid:28420982 - - complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) - - - - - pmid:28420982 - - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) - + - - - pmid:28420982 - - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates") - + @@ -110560,90 +110648,94 @@

Statements

- pmid:28420982 + pmid:8282104 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) + a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph)) + + + + - pmid:28420982 + pmid:8282104 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) + complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:28420982 + pmid:8282104 - a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") + a(HBP:HBP00006) association p(HGNC:CDK5) - pmid:28420982 + pmid:8282104 - a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques") + a(HBP:HBP00006) association p(HGNC:PRKACA) - pmid:28420982 + pmid:8282104 - a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") + a(HBP:HBP00006) association p(FPLX:ERK) - pmid:28420982 + pmid:8282104 - a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils") + a(HBP:HBP00006) association p(FPLX:GSK3) - pmid:28420982 + pmid:30116051 - a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils") + a(HBP:HBP00006) decreases act(complex(GO:"proteasome complex")) - pmid:28420982 + pmid:30116051 - a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) + a(HBP:HBP00006) decreases bp(GO:"chaperone-mediated autophagy") - pmid:28420982 + pmid:26458742 - a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + a(HBP:HBP00006) increases tloc(p(HGNC:MAPT), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) - pmid:28420982 + pmid:26458742 - a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") + a(HBP:HBP00006) causesNoChange bp(GO:"cell death") @@ -110654,2963 +110746,2998 @@

Statements

- pmid:28420982 + pmid:27594586 - a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies) + g(DBSNP:rs63751011) increases p(HGNC:MAP2) - - - - - pmid:28420982 + pmid:27594586 - complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) + g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") - pmid:28420982 + pmid:27594586 - p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") + g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) - pmid:26631930 + pmid:27594586 - p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates") + g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) - pmid:26631930 + pmid:27594586 - p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") + g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) - pmid:28420982 + pmid:27594586 - p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") + g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") - - - - - - - pmid:28420982 + pmid:27594586 - complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) + g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") - pmid:23702978 + pmid:27594586 - complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") + g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) + g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9)) - pmid:29276758 + pmid:27594586 - path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + g(DBSNP:rs63751011) increases r(HGNC:MMP9) - pmid:29311797 + pmid:27594586 - p(HGNC:HSP90AA1) association bp(GO:growth) + g(DBSNP:rs63751011) increases r(HGNC:MMP9) - pmid:29311797 + pmid:27594586 - p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") + g(DBSNP:rs63751011) increases r(HGNC:MMP2) - pmid:29311797 + pmid:27594586 - p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) + g(DBSNP:rs63751011) increases r(HGNC:MMP2) - pmid:29311797 + pmid:27594586 - p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") + g(DBSNP:rs63751011) increases bp(GO:"neuron death") - pmid:29311797 + pmid:27594586 - bp(GO:growth) association p(HGNC:HSP90AA1) + g(DBSNP:rs63751011) increases a(HBP:HBP00045) - pmid:29311797 + pmid:27594586 - bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) + g(DBSNP:rs63751011) decreases a(HBP:HBP00044) - pmid:29311797 + pmid:27594586 - bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) + path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) + a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") - pmid:29311797 + pmid:8726973 - bp(GO:"embryo development") association p(HGNC:HSP90AB1) + a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) - pmid:29311797 + pmid:23666762 - bp(GO:"cell maturation") association p(HGNC:HSP90AB1) + a(CHEBI:staurosporine) decreases act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) - pmid:29311797 + pmid:23001711 - bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) + a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin)) - pmid:29311797 + pmid:23001711 - bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) + a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:29311797 + pmid:27594586 - p(HGNC:PPID) isA a(MESH:Immunophilins) + a(CHEBI:rotenone) increases bp(HBP:HBP00037) + + + + - pmid:29311797 + pmid:27594586 - p(HGNC:PPID) decreases a(HBP:"Tau fibrils") + composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + + + + - pmid:29311797 + pmid:27594586 - p(HGNC:PPID) decreases a(HBP:"Tau aggregates") + composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") - pmid:29311797 + pmid:27594586 - p(HGNC:PPID) increases bp(GO:memory) + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) - pmid:29311797 + pmid:27594586 - p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - p(HGNC:FKBPL) isA a(MESH:Immunophilins) + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:29311797 + pmid:27594586 - complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) - - - - - pmid:29311797 + pmid:27594586 - bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates") + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) - pmid:29311797 + pmid:27594586 - p(HGNC:TOMM34) decreases path(MESH:Tauopathies) + p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) - - - - - pmid:29311797 + pmid:27594586 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) + p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) + p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) - pmid:21367866 + pmid:27594586 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(kin)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) - pmid:11943212 + pmid:27594586 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) - pmid:11943212 + pmid:27594586 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:11943212 + pmid:27594586 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) - pmid:11943212 + pmid:27594586 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) - - - pmid:29311797 + pmid:27594586 - p(HGNC:S100A1) increases p(HGNC:MAPT) + p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) - pmid:29311797 + pmid:27594586 - p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph)) + p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) - - - pmid:29311797 + pmid:27594586 - complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) - - - + + + pmid:30116051 + + p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1)) + - pmid:29311797 + pmid:30116051 - complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) + p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1)) - + + + pmid:30116051 + + p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1)) + - + + + pmid:30116051 + + p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1)) + - pmid:29311797 + pmid:30116051 - p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) + p(HGNC:FOXO1) increases bp(GO:macroautophagy) - pmid:29311797 + pmid:30116051 - p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) + p(HGNC:FOXO3) increases bp(GO:macroautophagy) - pmid:29311797 + pmid:30116051 - p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90)) + p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) - pmid:29311797 + pmid:30116051 - p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) + p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1)) + + - pmid:29311797 + pmid:30116051 - a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") - pmid:29311797 + pmid:30116051 - a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1)) - pmid:29311797 + pmid:30116051 - a(PUBCHEM:14719853) decreases p(HGNC:MAPT) + p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) - pmid:29311797 + pmid:30116051 - a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) + act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) - pmid:29311797 + pmid:30116051 - a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) + p(HGNC:MAPT, pmod(HBP:HBP00007)) decreases deg(p(HGNC:MAPT)) - pmid:29311797 + pmid:30116051 - a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) + p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") - pmid:29311797 + pmid:30116051 - a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") + p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) + + - pmid:29311797 + pmid:30116051 - a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory) + p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") - pmid:29121589 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis) + p(HGNC:GBA, var("?")) decreases bp(GO:autophagy) - pmid:29121589 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis) + p(HGNC:GBA, var("?")) increases a(HBP:HBP00016) - pmid:29121589 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) + p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") + + - pmid:29121589 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) + p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") + + - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) + p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) + p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + + - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100") + p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") - pmid:23294633 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) - pmid:11606569 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif") + a(CHEBI:clonidine) increases bp(GO:autophagy) - pmid:11606569 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif") + a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) - pmid:27716675 + pmid:30116051 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:neuroinflammation) + a(CHEBI:Rilmenidine) increases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - r(MGI:Mapt) partOf a(CL:0000127) + a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) - pmid:26751493 + pmid:30116051 - r(MGI:Mapt) partOf a(CL:0000128) + p(HGNC:CAPN2) decreases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) - pmid:26751493 + pmid:24027553 - p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAPN2) positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) increases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) increases deg(p(HGNC:MAPT)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) increases deg(p(HGNC:SNCA)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CAST) increases deg(p(HGNC:SOD1)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Calpeptin) increases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) - pmid:28176663 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") + a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) - pmid:8226987 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT)) + a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:selenomethionine) increases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments") + p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) + + + + - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:metformin) increases act(p(FPLX:AMPK)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:metformin) increases bp(GO:autophagy) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta") - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) - pmid:26751493 + pmid:30116051 - p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) + a(CHEBI:metformin) decreases bp(GO:"neuron death") - pmid:26751493 + pmid:23528736 - p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates") - pmid:10464280 + pmid:30116051 - p(HBP:"microtubule-binding region") isA p(HGNC:MAPT) + a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) - pmid:10464280 + pmid:30116051 - p(HBP:"microtubule-binding region") association act(complex(GO:"protein phosphatase type 2A complex")) + a(CHEBI:calcitriol) increases bp(GO:autophagy) - pmid:10464280 + pmid:29626319 - p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) + a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - pmid:18500754 + pmid:29626319 - p(HBP:"microtubule-binding region") association p(HGNC:HSPA8) + a(CHEBI:calcitriol) decreases p(HGNC:AGER) - pmid:18500754 + pmid:29626319 - p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") + a(CHEBI:calcitriol) increases p(HGNC:LRP1) + + + + - pmid:8391280 + pmid:30116051 - p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) + complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) - pmid:26751493 + pmid:26631930 - p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") + p(HGNC:FUS) decreases p(HBP:"4R tau") - pmid:26751493 + pmid:26631930 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") + p(HGNC:FUS) decreases p(HBP:"Tau isoform F (441 aa)") - pmid:17493042 + pmid:26631930 - p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") + p(HGNC:FUS) decreases p(HBP:"Tau isoform C (410 aa)") - pmid:26751493 + pmid:26631930 - p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") + p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:17493042 + pmid:30116051 - p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274")) + a(CHEBI:fisetin) increases bp(GO:macroautophagy) - pmid:23407988 + pmid:30116051 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau") + a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) - pmid:23407988 + pmid:30116051 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") + a(CHEBI:fisetin) decreases a(HBP:HBP00018) - pmid:26751493 + pmid:30116051 - p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3") + p(HGNC:ABL1) decreases bp(GO:macroautophagy) - pmid:26751493 + pmid:29191965 - g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") + p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - pmid:26751493 + pmid:26631930 - p(HBP:"projection domain") association p(HGNC:LCK) + p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) - pmid:26751493 + pmid:17493042 - p(HBP:"projection domain") association p(HGNC:FGR) + p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) - pmid:26751493 + pmid:23687953 - p(HBP:"projection domain") association p(HGNC:SRC) + act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363)) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association p(HGNC:GRB2) + a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association p(FPLX:PLC) + a(CHEBI:nilotinib) increases bp(GO:macroautophagy) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) + a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") + a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association p(HGNC:PIN1) + a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") partOf p(HGNC:MAPT) + a(CHEBI:cilostazol) increases bp(GO:macroautophagy) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association p(HGNC:FYN) + a(CHEBI:cilostazol) increases p(HGNC:BECN1) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association p(HGNC:DLG4) + a(CHEBI:cilostazol) increases p(HGNC:ATG5) - pmid:26751493 + pmid:30116051 - p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") + a(CHEBI:cilostazol) increases p(HGNC:MAP1LC3A) - pmid:26751493 + pmid:30116051 - p(HGNC:FGR) association p(HBP:"projection domain") + a(CHEBI:cilostazol) decreases p(FPLX:mTORC1) - pmid:26751493 + pmid:30116051 - p(HGNC:FGR) association a(HBP:"projection domain") + a(CHEBI:cilostazol) increases p(HGNC:CTSB) - pmid:26751493 + pmid:30116051 - p(HGNC:GRB2) association p(HBP:"projection domain") + a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) - - - pmid:26751493 + pmid:30116051 - p(HGNC:GRB2) association a(HBP:"projection domain") + a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172)) - pmid:26751493 + pmid:30116051 - a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") + a(CHEBI:cilostazol) increases bp(GO:cognition) - pmid:26751493 + pmid:30116051 - a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain") + a(CHEBI:cilostazol) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) - pmid:26751493 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac)) - pmid:26631930 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac)) - pmid:22057784 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) - pmid:17050703 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) + + - pmid:21427723 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + a(CHEBI:Isorhynchophylline) increases p(HGNC:BECN1) - pmid:21427723 + pmid:30116051 - path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy") + a(CHEBI:Isorhynchophylline) decreases a(HBP:HBP00016) + + + + - pmid:26751493 + pmid:30116051 - path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") + complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) - pmid:26751493 + pmid:30116051 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) - pmid:26631930 + pmid:30116051 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + a(PUBCHEM:16240819) increases bp(GO:macroautophagy) - pmid:26631930 + pmid:30116051 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) - pmid:26631930 + pmid:30116051 - p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau")) + p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") isA p(HGNC:MAPT) + a(CHEBI:"epothilone A") increases a(GO:microtubule) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") + a(CHEBI:"epothilone D") increases a(GO:microtubule) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"ghost tangles") + a(CHEBI:"epothilone D") increases bp(GO:cognition) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") + a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") + a(PUBCHEM:129688311) decreases a(HBP:HBP00016) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") + a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta") - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") + a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") + a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf complex(GO:dendrite) + a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf a(MESH:Neuropil) + act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) - pmid:23407988 + pmid:30116051 - p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") + act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") - pmid:26655600 + pmid:30116051 - p(HBP:"3R tau") negativeCorrelation bp(GO:"neurofibrillary tangle assembly") + act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta") - pmid:26655600 + pmid:30116051 - p(HBP:"3R tau") positiveCorrelation complex(GO:"Pick body") + a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) - pmid:28775333 + pmid:30116051 - p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) + a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy) - pmid:28775333 + pmid:30116051 - p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") + a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(CHEBI:ambroxol) increases p(HGNC:GBA) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(CHEBI:ambroxol) increases bp(GO:macroautophagy) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates") + a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(CHEBI:ambroxol) decreases p(HGNC:SNCA) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript)) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Gly272Val")) decreases p(HBP:"4R tau") + a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau") + a(PUBCHEM:46216556) decreases a(HBP:HBP00017) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin)) + + + + + + - pmid:26631930 + pmid:30116051 - p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates") + complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) - pmid:26751493 + pmid:23702978 - p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:BIRC2) decreases complex(GO:ripoptosome) - pmid:26751493 + pmid:30116051 - p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNC:SESN2) increases act(p(FPLX:AMPK)) - pmid:26751493 + pmid:30116051 - p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") + p(HGNC:SESN2) increases bp(GO:macroautophagy) - pmid:26751493 + pmid:30116051 - g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") + p(HGNC:SESN2) increases bp(GO:macroautophagy) - pmid:26751493 + pmid:30116051 - g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") + p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:26751493 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") + p(HGNC:PLG) increases deg(p(HGNC:SNCA)) - pmid:25974414 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") + p(HGNC:KLK6) increases deg(p(HGNC:SNCA)) - pmid:22002427 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") + a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) - pmid:25974414 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE)) - pmid:25974414 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) + a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) - pmid:22002427 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) - pmid:22002427 + pmid:30116051 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) + a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME)) - pmid:26751493 + pmid:30116051 - p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) + a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) - pmid:26751493 + pmid:30116051 - p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") + a(CHEBI:somatostatin) increases p(HGNC:IDE) - pmid:26751493 + pmid:30116051 - p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:somatostatin) increases sec(p(HGNC:IDE)) - - - pmid:26751493 + pmid:30116051 - p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) - - - - - pmid:26751493 + pmid:29626319 - complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) + a(CHEBI:somatostatin) increases p(HGNC:IDE) - pmid:26751493 + pmid:30116051 - bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + a(CHEBI:somatostatin) increases p(HGNC:MME) - pmid:26751493 + pmid:30116051 - a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + a(CHEBI:somatostatin) increases sec(p(HGNC:MME)) - pmid:26751493 + pmid:30116051 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89")) + a(CHEBI:somatostatin) increases act(p(HGNC:MME)) - pmid:26751493 + pmid:29626319 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I")) + a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta")) - pmid:29281045 + pmid:30116051 - p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:GRN) increases act(p(HGNC:MME)) - pmid:26751493 + pmid:30116051 - act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") + p(HGNC:GRN) decreases a(HBP:HBP00018) - pmid:26751493 + pmid:30116051 - p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:28019679 + pmid:30116051 - p(HGNC:CASP1) increases act(p(HGNC:IL18)) + a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) - pmid:23702978 + pmid:30116051 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) - pmid:23702978 + pmid:30116051 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta")) - pmid:23702978 + pmid:29626319 - act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18)) + p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta")) - pmid:24561250 + pmid:29626319 - p(HGNC:CASP1) increases p(HGNC:IL18) + p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:29626319 - p(HGNC:CASP1) increases p(HGNC:IL18) + p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") - pmid:27314526 + pmid:26195256 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + act(p(HGNC:AQP4)) decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) - pmid:27314526 + pmid:29626319 - sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:AQP4) increases a(HP:"glymphatic system") - pmid:27314526 + pmid:29626319 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:AQP4) increases a(HP:"glymphatic system") - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + a(CHEBI:6872) decreases a(HBP:HBP00006) - pmid:28019679 + pmid:23484434 - p(HGNC:CASP1) increases act(p(HGNC:IL1B)) + a(CHEBI:8028) causesNoChange a(HBP:HBP00006) - pmid:23702978 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:44932) causesNoChange a(HBP:HBP00006) - pmid:23702978 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:3647) causesNoChange a(HBP:HBP00006) - pmid:23702978 + pmid:23484434 - act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B)) + a(CHEBI:87637) decreases a(HBP:HBP00006) - pmid:23702978 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:22580) decreases a(HBP:HBP00006) - pmid:24561250 + pmid:23484434 - p(HGNC:CASP1) increases p(HGNC:IL1B) + a(CHEBI:1457) decreases a(HBP:HBP00018) - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:10642) decreases a(HBP:HBP00018) - pmid:27314526 + pmid:23484434 - sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:4806) decreases a(HBP:HBP00018) - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:4806) decreases a(HBP:HBP00006) - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + a(CHEBI:74460) decreases a(HBP:HBP00018) - pmid:28019679 + pmid:23484434 - act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") + a(HBP:HBP00021) decreases a(HBP:HBP00018) - pmid:28019679 + pmid:23484434 - act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF)) + a(HBP:HBP00019) decreases a(HBP:HBP00018) - pmid:28019679 + pmid:23484434 - act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) + a(CHEBI:90) causesNoChange a(HBP:HBP00006) - pmid:23702978 + pmid:23484434 - act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) + a(CHEBI:18152) decreases a(HBP:HBP00006) - - - pmid:24561250 + pmid:23484434 - p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + a(CHEBI:3441) decreases a(HBP:HBP00018) - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) + a(CHEBI:3441) decreases a(HBP:HBP00006) - pmid:27314526 + pmid:23484434 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) + a(CHEBI:6710) decreases a(HBP:HBP00006) - pmid:26751493 + pmid:23484434 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") + a(CHEBI:6710) decreases a(HBP:HBP00018) + + + + - pmid:27041503 + pmid:23484434 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1) + a(CHEBI:112284) decreases a(HBP:HBP00006) - pmid:27041503 + pmid:23484434 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"actin filament polymerization") + a(HBP:HBP00020) decreases a(HBP:HBP00006) - pmid:26751493 + pmid:29024336 - a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") + path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:26751493 + pmid:29024336 - a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") + bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") + bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") + bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053)) - pmid:26751493 + pmid:29024336 - a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) - pmid:26751493 + pmid:29024336 - a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006) - pmid:26751493 + pmid:29024336 - a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100) - pmid:26751493 + pmid:29024336 - a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) - pmid:26751493 + pmid:29024336 - a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Thr, 205)) + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 262)) + p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 400)) + p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 404)) + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 409)) + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 422)) + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) - pmid:26458742 + pmid:29024336 - p(HBP:HBP00056, var("p.Pro301Leu")) increases a(HBP:HBP00006) + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) - - - - - - - - - - - - - - - pmid:26195256 + pmid:29024336 - bp(GO:"import into cell") decreases a(HBP:"amyloid-beta derived diffusible ligands") + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) - pmid:26195256 + pmid:30126037 - a(MESH:"Blood-Brain Barrier") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) - pmid:26195256 + pmid:30126037 - act(a(MESH:"Blood-Brain Barrier")) association p(HGNC:PPIA) + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) - pmid:26195256 + pmid:30126037 - a(MESH:"Extracellular Fluid") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) - pmid:26195256 + pmid:30126037 - p(HGNC:CLU) association path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) - pmid:26195256 + pmid:30126037 - path(MESH:Hypertension) association path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) - pmid:26195256 + pmid:30126037 - path(MESH:"Craniocerebral Trauma") association path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) - pmid:26195256 + pmid:30126037 - path(MESH:"Sleep Initiation and Maintenance Disorders") association path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) - pmid:26195256 + pmid:30126037 - path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") - pmid:26195256 + pmid:30126037 - a(MESH:"Cerebral Ventricles") association path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) - pmid:26195256 + pmid:30126037 - p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation p(HGNC:APP, loc(GO:"extracellular region")) + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) - pmid:26195256 + pmid:30126037 - act(p(MESH:Ubiquitin)) decreases p(HGNC:APP) + p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) - pmid:26195256 + pmid:30126037 - act(p(MESH:Ubiquitin)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") - pmid:26195256 + pmid:30126037 - p(MESH:Ubiquitin) decreases p(HGNC:MAPT) + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") - - - - - pmid:26195256 + pmid:30126037 - act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) decreases p(HGNC:APP) + p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") - pmid:26195256 + pmid:30126037 - act(p(MESH:"Amyloid Precursor Protein Secretases")) increases a(CHEBI:"amyloid-beta") + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") - pmid:26195256 + pmid:29024336 - a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) - pmid:26195256 + pmid:29024336 - act(p(MESH:Cathepsins)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) - pmid:26195256 + pmid:29024336 - p(MESH:Neprilysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) - pmid:26195256 + pmid:29024336 - p(MESH:"Matrix Metalloproteinase 9") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) - pmid:26195256 + pmid:29024336 - p(MESH:"Matrix Metalloproteinase 2") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009) - pmid:26195256 + pmid:29024336 - p(MESH:"Matrix Metalloproteinase 3") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") - pmid:26195256 + pmid:29024336 - p(MESH:"Glutamate Carboxypeptidase II") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") - pmid:26195256 + pmid:29024336 - p(MESH:"Endothelin-Converting Enzymes") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) - pmid:26195256 + pmid:29024336 - p(MESH:"Tissue Plasminogen Activator") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) - pmid:26195256 + pmid:29024336 - p(MESH:Fibrinolysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) - pmid:26195256 + pmid:29024336 - p(HGNC:ACE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) + p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) regulates a(MESH:"Body Fluids") + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + + + + + + + + - pmid:29626319 + pmid:29024336 - p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") + complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + - pmid:29626319 + pmid:29024336 - act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + - pmid:26195256 + pmid:29024336 - a(MESH:"Muscle, Smooth, Vascular") decreases a(CHEBI:"amyloid-beta") + complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + - pmid:26195256 + pmid:29024336 - a(MESH:Insulin) increases a(CHEBI:"amyloid-beta") + a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") - pmid:26195256 + pmid:28019679 - a(MESH:Insulin) association a(CHEBI:"amyloid-beta") + a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:26195256 + pmid:28019679 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) + a(CHEBI:paraquat) increases p(HGNC:CASP1) - pmid:26195256 + pmid:28019679 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) + a(CHEBI:paraquat) increases p(HGNC:IL1B) + + + + - pmid:29626319 + pmid:29024336 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) + composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + + + + - pmid:29626319 + pmid:29024336 - p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta") + composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + + + + - pmid:26195256 + pmid:29024336 - p(HGNC:A2M) regulates a(CHEBI:"amyloid-beta") + composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + + + + - pmid:26195256 + pmid:29024336 - p(HGNC:LRP2) regulates a(CHEBI:"amyloid-beta") + composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + + + + - pmid:26195256 + pmid:29024336 - p(HGNC:PPIA) association act(a(MESH:"Blood-Brain Barrier")) + composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + + + + - pmid:26195256 + pmid:29024336 - bp(HBP:"perivascular drainage pathways") association a(CHEBI:"amyloid-beta") + composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + + + + - pmid:26195256 + pmid:29024336 - path(HBP:"high-fat prenatal maternal diet") increases a(CHEBI:"amyloid-beta") + composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") - pmid:26195256 + pmid:23528736 - path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) + a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) - pmid:26195256 + pmid:23528736 - path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow") + a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) - pmid:29626319 + pmid:29024336 - path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") + a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:26195256 + pmid:29024336 - act(p(MESH:Lysosomes)) decreases p(HGNC:MAPT) + a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy") - pmid:26195256 + pmid:29024336 - p(MESH:"Cyclic AMP-Dependent Protein Kinases") increases p(HGNC:MAPT, pmod(Ph)) + a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:26195256 + pmid:29024336 - act(p(MESH:Calpain)) decreases p(HGNC:MAPT) + a(HBP:HBP00055) decreases deg(p(MGI:Mapt)) - pmid:26195256 + pmid:29024336 - p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic") + a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy") - pmid:27373205 + pmid:29024336 - p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates") + a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:27373205 + pmid:29024336 - p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers") + p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) - pmid:27373205 + pmid:29024336 - p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport") + p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) - pmid:27373205 + pmid:29024336 - p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport") + p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - - - - - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers") + p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers") + p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport") + p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport") + p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - + + + pmid:29024336 + + p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))) + - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") + p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers") + p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) decreases bp(GO:"anterograde axonal protein transport") + p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:27373205 + pmid:29024336 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) causesNoChange bp(GO:"retrograde axonal protein transport") + p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) - - - + + + pmid:29024336 + + p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + - pmid:26631930 + pmid:29024336 - g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) - pmid:26631930 + pmid:29024336 - g(HGNC:MIR132) decreases p(HBP:"4R tau") + p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) - pmid:26631930 + pmid:29215007 - g(HGNC:MIR219A1) increases complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) + a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) @@ -113621,92 +113748,97 @@

Statements

- pmid:26631930 + pmid:29215007 - complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) decreases p(HGNC:MAPT) + complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169) - - - pmid:26631930 - - p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") - + + + + + + + + + + + - pmid:26631930 + pmid:29215007 - complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) + composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") + + - pmid:26631930 + pmid:24760868 - p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") + complex(GO:"filamentous actin") association p(HGNC:MAPT) - pmid:26631930 + pmid:24760868 - a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) + complex(GO:"filamentous actin") increases p(HGNC:MAPT) - pmid:26631930 + pmid:24760868 - complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2) + complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) - pmid:26631930 + pmid:17187063 - p(HGNC:SRSF2) increases p(HBP:"4R tau") + complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:29226865 + pmid:29215007 - act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") + a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:26631930 + pmid:29215007 - p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) - - - pmid:29226865 + pmid:29215007 - act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) + a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) @@ -113717,27 +113849,31 @@

Statements

- pmid:26631930 + pmid:29215007 - complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) + + + + - pmid:26631930 + pmid:29215007 - complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(HBP:Neurodegeneration) + complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) - pmid:24561250 + pmid:29215007 - a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) + a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) @@ -113748,139 +113884,134 @@

Statements

- pmid:26631930 + pmid:29215007 - complex(a(GO:microtubule), p(HBP:"4R tau")) increases bp(GO:"microtubule polymerization") + p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") - pmid:20133804 + pmid:29215007 - bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) + p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") - pmid:19459590 + pmid:29215007 - bp(GO:"microtubule polymerization") positiveCorrelation act(p(HGNC:MAPT)) + p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") - - - - - pmid:26631930 + pmid:29215007 - complex(a(GO:microtubule), p(HBP:"3R tau")) increases bp(GO:"microtubule polymerization") + p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) - pmid:26631930 + pmid:29215007 - p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") - pmid:26631930 + pmid:29215007 - p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") - pmid:21311567 + pmid:29215007 - act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") - pmid:22952452 + pmid:29215007 - act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") - pmid:21311567 + pmid:22072628 - act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") + bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph)) - pmid:22952452 + pmid:22072628 - p(HGNC:MARK1) negativeCorrelation p(HGNC:TRAK1) + bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) - pmid:22952452 + pmid:29215007 - p(HGNC:MARK1) negativeCorrelation p(HGNC:RHOT1) + p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170) - pmid:26631930 + pmid:29215007 - p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170) - - - pmid:26631930 - - p(HGNC:MAPT, pmod(Ph, Ser, 214), pmod(Ph, Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - + - pmid:26631930 + pmid:29215007 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + - pmid:26631930 + pmid:29215007 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170) @@ -113889,483 +114020,473 @@

Statements

- - - - - pmid:26631930 + pmid:29215007 - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170) - - - pmid:26631930 - - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") - + - pmid:26631930 + pmid:29215007 - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases bp(GO:"axonal transport") + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") - - - pmid:26631930 - - complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") - + - pmid:19491104 + pmid:29215007 - act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) + p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) - pmid:19491104 + pmid:29215007 - act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) + p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") - - - pmid:19491104 - - act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") - + - pmid:26631930 + pmid:29215007 - p(HGNC:EP300) increases p(HGNC:MAPT, pmod(Ac, Lys)) + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") - - - pmid:11691934 - - p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac)) - + + + + + - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163)) + p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170) + + + + - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180)) + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254)) + p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274)) + act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:20869593 + pmid:21311567 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281)) + act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:20869593 + pmid:24251416 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:20869593 + pmid:23001711 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) + act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293)) - pmid:20869593 + pmid:24251416 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352)) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305)) - pmid:20869593 + pmid:24251416 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370)) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) - pmid:20869593 + pmid:24251416 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) - pmid:20869593 + pmid:29215007 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385)) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) - pmid:20869593 + pmid:24251416 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395)) + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356)) - pmid:26631930 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280))) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416)) - pmid:26631930 + pmid:24251416 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416)) - pmid:29276758 + pmid:21882945 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:21427723 + pmid:21882945 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) - pmid:26631930 + pmid:21311567 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") + act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") - pmid:26631930 + pmid:24251416 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352)) - pmid:26631930 + pmid:24251416 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413)) - pmid:29276758 + pmid:25031639 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons) + p(HGNC:MARK2) increases a(HBP:"Tau epitope, 12E8") + + - pmid:29276758 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") + p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:28855586 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly") - pmid:28287136 + pmid:17493042 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - pmid:28287136 + pmid:17493042 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:28287136 + pmid:24251416 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"VQIINK motif") + p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2") - pmid:26940749 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:26940749 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration) + p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly") - pmid:26192747 + pmid:24251416 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2") - pmid:26192747 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region") + p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:21427723 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") + p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly") - pmid:26631930 + pmid:17493042 - p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163))) + p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - pmid:28855586 + pmid:17493042 - p(HGNC:MAPT, pmod(Ac, Lys, 163)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:26192747 + pmid:28760828 - p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates") - pmid:26631930 + pmid:28760828 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281))) + p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HGNC:HDAC6) - pmid:28855586 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:28287136 + pmid:29215007 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly") + + + + - pmid:28287136 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles") - pmid:28287136 + pmid:29540553 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) partOf p(HBP:"VQIINK motif") + p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3) @@ -114374,783 +114495,841 @@

Statements

pmid:27041503 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1) + p(HGNC:MAPT, pmod(Ac)) decreases p(HGNC:WWC1) - pmid:27041503 + pmid:20869593 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"actin filament polymerization") + p(HGNC:MAPT, pmod(Ac)) negativeCorrelation act(p(HGNC:SIRT1)) - pmid:26631930 + pmid:20869593 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8") - pmid:28855586 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles") - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region") + p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259))) + act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) + + + + + + + + - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph)) + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates") + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:Thrombin) increases bp(GO:coagulation) - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region") + a(CHEBI:Thrombin) increases bp(HBP:"neurite retraction") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290))) + a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates") + a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321))) + a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph)) + act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates") + act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac)) + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) - pmid:26192747 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region") + act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) - pmid:28760828 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) - pmid:28760828 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353))) + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + + + + - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:26390242 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:26390242 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + act(p(HGNCGENEFAMILY:Calpains)) association a(HBP:Excitotoxicity) - pmid:26390242 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration) - pmid:26390242 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration) + act(p(HGNC:NPEPPS)) association a(MESH:Brain) - pmid:29540553 + pmid:24027553 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1)) + p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments") + p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:NPEPPS) decreases p(HGNC:MAPT) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") + p(HGNC:NPEPPS) decreases path(MESH:Paralysis) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") + p(HGNC:NPEPPS) decreases path(MESH:Gliosis) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:NPEPPS) association bp(GO:autophagy) - pmid:19517062 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product") + p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia") - pmid:19517062 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.P301L")) association path(HBP:Neurodegeneration) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:deamidation)) increases a(HBP:"Tau aggregates") + p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(HBP:"Tau aggregates") + p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L"))) - pmid:26631930 + pmid:26751493 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) + p(HGNC:PIN1) association p(HBP:"projection domain") + + + + - pmid:26631930 + pmid:26751493 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:PIN1) association a(HBP:"projection domain") - pmid:16566606 + pmid:25899010 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") + p(HGNC:PIN1) decreases a(HBP:Excitotoxicity) - pmid:22057784 + pmid:25899010 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:PIN1) negativeCorrelation p(HGNC:DAPK1) + + - pmid:18562203 + pmid:24964035 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) + p(HGNC:PIN1) increases deg(p(HGNC:SMAD2)) - pmid:18562203 + pmid:24964035 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2)) - pmid:17050703 + pmid:23157676 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") - pmid:16566606 + pmid:26996941 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments") + act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235)) + + + + + + - pmid:16566606 + pmid:22926167 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) + act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:26631930 + pmid:19401603 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:PIN1)) positiveCorrelation act(p(HGNC:PPP2CA)) - pmid:17050703 + pmid:19401603 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:PIN1)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) + deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:MAPT, frag("561_685")) increases a(HBP:"Tau aggregates") - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") + p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau")) - pmid:22057784 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1)) - pmid:17050703 + pmid:23157676 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + p(HBP:"cis p-tau") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17050703 + pmid:23157676 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") + p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") - pmid:17050703 + pmid:23157676 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") + p(HBP:"cis p-tau") partOf a(HBP:"dystrophic neurite") - pmid:17050703 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration") + a(HBP:"Tau fibrils") decreases a(MESH:"Dendritic Spines") - pmid:17050703 + pmid:29686391 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") + a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:17050703 + pmid:28420982 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle") - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments") + p(HGNC:MAPT, frag("?", "17kD")) association bp(GO:"apoptotic process") - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) + p(HGNC:MAPT, frag("?", "17kD")) increases bp(HBP:"neurite retraction") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments") + a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) - pmid:16566606 + pmid:24027553 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) - pmid:24869773 + pmid:24027553 - p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) - pmid:26631930 + pmid:24027553 - p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63)) + act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) + act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") - + + + pmid:24027553 + + p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") + - + + + pmid:24027553 + + p(HBP:"Tau C3") increases bp(GO:"apoptotic process") + - + + + pmid:24027553 + + p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") + - pmid:26631930 + pmid:24027553 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) + p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") - pmid:8391280 + pmid:24027553 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") + p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition) - pmid:8391280 + pmid:25374103 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) + p(HBP:"Tau C3") causesNoChange bp(GO:"cell death") - + + + pmid:25374103 + + p(HBP:"Tau C3") negativeCorrelation p(HGNC:STUB1) + - pmid:26631930 + pmid:25374103 - complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) + p(HBP:"Tau C3") positiveCorrelation act(p(HGNC:CASP3)) + + + pmid:25374103 + + p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + + + + + pmid:25374103 + + p(HBP:"Tau C3") negativeCorrelation bp(GO:"mitochondrion transport along microtubule") + + - pmid:26631930 + pmid:24027553 - complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)")) + p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process") @@ -115161,510 +115340,525 @@

Statements

- pmid:26631930 + pmid:24027553 - complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") + composite(p(HBP:"amyloid-beta oligomers"), p(HGNC:CASP3)) increases p(HBP:"Tau C3") - pmid:26631930 + pmid:24027553 - complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") + a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) + + + + - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub))) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub))) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") + p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Leu266Val")) decreases p(HBP:"4R tau") + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau") + act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates")) - pmid:26631930 + pmid:24027553 - p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers")) - pmid:26631930 + pmid:24027553 - p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") + act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) - pmid:17493042 + pmid:24027553 - p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2") + a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT) - pmid:17493042 + pmid:24027553 - p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) - pmid:28002468 + pmid:24027553 - p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) + act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) - pmid:28002468 + pmid:21882945 - p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) + a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) - pmid:11606569 + pmid:21882945 - p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) - pmid:11606569 + pmid:24027553 - p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates") - pmid:11606569 + pmid:24027553 - p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates") + path(MESH:"Alzheimer disease, familial, type 3") association p(HGNC:PSEN1) - pmid:26631930 + pmid:24027553 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) - pmid:26631930 + pmid:24027553 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + bp(MESH:Autophagy) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pmid:24027553 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau fibrils") + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) - pmid:17493042 + pmid:24027553 - p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") + bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) - pmid:23531502 + pmid:24027553 - p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:17493042 + pmid:24027553 - p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:23531502 + pmid:24027553 - p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L")) - pmid:19363271 + pmid:24027553 - p(HBP:"VQIVYK motif") association p(FPLX:HSP90) + bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates") - pmid:19363271 + pmid:24027553 - p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4") + bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) - pmid:19363271 + pmid:24027553 - p(HBP:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) - pmid:23531502 + pmid:24027553 - p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif") + bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) - pmid:28002468 + pmid:24027553 - p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) + bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S")) - pmid:11606569 + pmid:24027553 - p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S")) - pmid:11606569 + pmid:24027553 - p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) - pmid:11606569 + pmid:24027553 - p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates") + bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") - pmid:26903089 + pmid:24027553 - p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) + bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3")) - pmid:26631930 + pmid:24027553 - a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + bp(MESH:Autophagy) decreases p(HBP:"Tau C3") - pmid:26631930 + pmid:24027553 - a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, AT8") - pmid:26631930 + pmid:24027553 - p(HGNC:YWHAZ) increases a(HBP:"Tau aggregates") + bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, PHF1") - pmid:12551948 + pmid:24027553 - p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + bp(MESH:Autophagy) decreases a(HBP:"Tau epitope, 12E8") - pmid:12551948 + pmid:24027553 - p(HGNC:YWHAZ) association p(HGNC:MAPT) + bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers")) + + + + - pmid:12551948 + pmid:24027553 - p(HGNC:YWHAZ) association p(HGNC:GSK3B) + composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) - pmid:12551948 + pmid:24027553 - p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) + composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases deg(p(HGNC:MAPT)) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("151_391")) increases a(HBP:"Tau aggregates") + a(MESH:"3-methyladenine") decreases bp(MESH:Autophagy) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates") + a(MESH:"3-methyladenine") increases p(HGNC:MAPT, frag("?")) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration) + a(MESH:Trehalose) increases bp(MESH:Autophagy) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") + a(MESH:Trehalose) increases bp(MESH:Autophagy) - pmid:26631930 + pmid:24027553 - p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) + a(MESH:Trehalose) increases bp(MESH:Autophagy) - pmid:26631930 + pmid:24027553 - p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates") + a(MESH:Trehalose) decreases a(HBP:"Tau aggregates") - pmid:26631930 + pmid:24027553 - p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) + a(MESH:Trehalose) decreases p(HGNC:MAPT) - pmid:26631930 + pmid:24027553 - tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:"amyloid-beta")) + p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration) - pmid:26631930 + pmid:30126037 - p(HGNC:SPAST) increases bp(GO:"microtubule severing") + p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a) - + + + pmid:19491104 + + p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1) + - pmid:26631930 + pmid:19491104 - complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse")) + p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1)) - pmid:26631930 + pmid:19491104 - complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta")) + p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1)) - pmid:26631930 + pmid:28173111 - p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) + p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l) + + - pmid:21548880 + pmid:24027553 - p(HGNC:GRIN2B) negativeCorrelation p(HGNC:TTBK1) + composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub)) @@ -115675,1224 +115869,1223 @@

Statements

- pmid:22817713 + pmid:16176937 - complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") + p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) - pmid:22817713 + pmid:16176937 - complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") + p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) - pmid:22817713 + pmid:20133804 - bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) + act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") - pmid:22817713 + pmid:20133804 - a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers") + act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") + + + + + + + + + + + + + + + + + + + + - pmid:22817713 + pmid:27671637 - a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates") + a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:22817713 + pmid:27671637 - p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") + a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:29334120 + pmid:27671637 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397)) + a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:29334120 + pmid:27671637 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:29334120 + pmid:22764226 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + a(HBP:"Tau epitope, PHF1") negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) - pmid:29334120 + pmid:22156579 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + a(HBP:"Tau epitope, PHF1") positiveCorrelation a(HBP:"Tau epitope, 12E8") - pmid:29334120 + pmid:22156579 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:26142647 + pmid:22156579 - act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) + a(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:21734277 + pmid:25125464 - act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(HBP:"Tau epitope, PHF1") positiveCorrelation p(MGI:Crhr1) - pmid:21734277 + pmid:19459590 - act(p(HGNC:PPP1CA)) increases act(p(HGNC:GSK3B)) + a(HBP:"Tau epitope, PHF1") decreases act(p(HGNC:MAPT)) - pmid:21734277 + pmid:25031639 - act(p(HGNC:PPP1CA)) negativeCorrelation bp(GO:"axonal transport") + a(HBP:"Tau epitope, PHF1") positiveCorrelation deg(p(HGNC:MAPT)) - pmid:25001178 + pmid:22156579 - act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(HBP:"Tau epitope, PHF1") positiveCorrelation a(CHEBI:"amyloid-beta") - pmid:22817713 + pmid:27671637 - p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") + a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:26671985 + pmid:27671637 - p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain") + a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:26671985 + pmid:22156579 - p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) + a(HBP:"Tau epitope, 12E8") positiveCorrelation a(HBP:"Tau epitope, PHF1") - - - - - pmid:22817713 + pmid:25031639 - composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") + a(HBP:"Tau epitope, 12E8") positiveCorrelation act(p(HGNC:HDAC6)) - pmid:29626319 + pmid:25031639 - p(FPLX:UBE2) increases deg(a(MESH:Proteins)) + a(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif") - pmid:29626319 + pmid:25031639 - a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) + a(HBP:"Tau epitope, 12E8") negativeCorrelation act(p(HGNC:STUB1)) - pmid:29626319 + pmid:27574109 - p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) + a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:29626319 + pmid:27574109 - a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process") + a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:29626319 + pmid:27574109 - a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") - pmid:29626319 + pmid:27574109 - a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") + a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29626319 + pmid:27574109 - a(HP:"glymphatic system") decreases p(HGNC:MAPT) + a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:29626319 + pmid:27574109 - a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") - pmid:29626319 + pmid:27574109 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") + a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:29626319 + pmid:27574109 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") + a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:29686391 - a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:29626319 + pmid:29686391 - p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) + tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)") - pmid:29626319 + pmid:29686391 - p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:29626319 + pmid:29686391 - a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin) - pmid:29626319 + pmid:29686391 - a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin") - pmid:29626319 + pmid:27574109 - p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta")) + bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") - pmid:29626319 + pmid:27574109 - p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta")) + bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau") - pmid:29626319 + pmid:27574109 - p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") - - - - - pmid:29626319 + pmid:27574109 - act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") - pmid:29626319 + pmid:27574109 - a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") - pmid:29626319 + pmid:27574109 - p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") - pmid:29626319 + pmid:27574109 - p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") - pmid:23702978 + pmid:27574109 - act(p(FPLX:TLR)) increases p(HGNC:NLRP3) + a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") - pmid:23702978 + pmid:27574109 - act(p(FPLX:TLR)) increases p(HGNC:IL1B) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") - pmid:29626319 + pmid:27574109 - p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:ABCA7) association bp(GO:phagocytosis) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:ABCA7) regulates bp(GO:phagocytosis) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:ABCA7) decreases p(HGNC:BACE1) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:CD33) association bp(GO:phagocytosis) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:SLC2A1) increases p(HGNC:LRP1) + a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) - pmid:29626319 + pmid:27574109 - p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") - pmid:29626319 + pmid:27574109 - p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") - pmid:29626319 + pmid:27574109 - p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") - pmid:29626319 + pmid:27574109 - p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") + a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) - pmid:29626319 + pmid:27574109 - a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") - pmid:29626319 + pmid:27574109 - a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") + a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") - pmid:29626319 + pmid:27574109 - p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) + a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") - pmid:29626319 + pmid:27574109 - p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") - - - pmid:29626319 + pmid:27574109 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") - - - pmid:29626319 + pmid:27574109 - a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") association a(GO:"Pick body") - - - - - pmid:29626319 + pmid:27574109 - complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta")) + a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) - - - pmid:29626319 + pmid:27574109 - composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta") + a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:29626319 + pmid:27574109 - a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) + a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:29626319 + pmid:27574109 - a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) + a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(MESH:tenuigenin) increases p(HGNC:PSMD7) + a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) + a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:wogonin) increases bp(GO:autophagy) + a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta") + a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph)) + a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - p(HGNC:NPAS4) increases bp(GO:autophagy) + a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(CHEBI:statin) increases sec(p(HGNC:IDE)) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29626319 + pmid:27574109 - a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29626319 + pmid:27574109 - a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") - pmid:29626319 + pmid:27574109 - a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - a(CHEBI:atorvastatin) increases sec(p(HGNC:MME)) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:nobiletin) increases act(p(HGNC:MME)) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29626319 + pmid:27574109 - a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29626319 + pmid:27574109 - a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") - pmid:29626319 + pmid:27574109 - a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29626319 + pmid:27574109 - p(HGNC:ANXA1) increases act(p(HGNC:MME)) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - - - - - pmid:29626319 + pmid:27574109 - complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta")) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29626319 + pmid:27574109 - a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta") + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29626319 + pmid:27574109 - a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta") + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + - pmid:29626319 + pmid:29191965 - a(CHEBI:oleocanthal) increases p(HGNC:LRP1) + p(HBP:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) + + - pmid:29626319 + pmid:17493042 - a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) + p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) - - - pmid:29238289 + pmid:27574109 - complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:29238289 + pmid:27574109 - complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) decreases a(MESH:Neurons) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - - - - - pmid:29238289 + pmid:27574109 - complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) decreases p(HGNC:MAPT) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29238289 + pmid:27574109 - p(HGNC:SNAP23) increases p(HGNC:MAPT) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29238289 + pmid:27574109 - p(MESH:"SNARE Proteins") increases p(HGNC:MAPT) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:29238289 + pmid:27574109 - p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:29238289 + pmid:27574109 - p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") - pmid:29238289 + pmid:27574109 - a(MESH:"Transport Vesicles") association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - + + + pmid:27574109 + + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + - pmid:17493042 + pmid:27574109 - a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:23531502 + pmid:27574109 - a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:10537045 + pmid:27574109 - a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:26751493 + pmid:27574109 - a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:17493042 + pmid:27574109 - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") - pmid:17493042 + pmid:27574109 - a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:21757739 + pmid:27574109 - a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:21757739 + pmid:27574109 - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:1918161 + pmid:27574109 - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") - pmid:10537045 + pmid:27574109 - a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:26751493 + pmid:27574109 - a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305")) + a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers") - pmid:23407988 + pmid:27574109 - p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau") + a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:23407988 + pmid:27574109 - p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") + a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers") - pmid:2123288 + pmid:27574109 - p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM) + a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") + a(HBP:pretangles) association a(HBP:"Tau oligomers") - pmid:23531502 + pmid:27574109 - p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") + a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336")) + a(HBP:pretangles) association p(HGNC:MAPT) @@ -116901,304 +117094,308 @@

Statements

pmid:23407988 - p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau") + a(HBP:pretangles) increases complex(GO:"dendritic tree") - pmid:23407988 + pmid:18239272 - p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") + a(HBP:pretangles) association p(HGNC:TTBK1) - pmid:23832849 + pmid:18239272 - p(HBP:"tubulin-binding repeat 3") increases a(HBP:"Tau aggregates") + a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:17493042 + pmid:18239272 - p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") + a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367")) + a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") - pmid:17493042 + pmid:27574109 - p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") - pmid:23407988 + pmid:27574109 - p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau") + a(HBP:"Braak_Stage I") association p(HGNC:MAPT) - pmid:17493042 + pmid:28176663 - a(HBP:"projection domain") partOf p(HGNC:MAPT) + a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") partOf p(HGNC:MAPT) + a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") - pmid:17493042 + pmid:27574109 - a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") + a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") - pmid:17493042 + pmid:27574109 - a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) + a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:LCK) + a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:FGR) + a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:SRC) + a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:GRB2) + a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(FPLX:PLC) + a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) + a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") + a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + + + + - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:PIN1) + composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:FYN) + composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:26751493 + pmid:27574109 - a(HBP:"projection domain") association p(HGNC:DLG4) + composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") - pmid:26751493 + pmid:17403556 - a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") + a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") - pmid:17493042 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain") + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph)) - pmid:8391280 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) + a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph)) - pmid:8391280 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT) + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:12551948 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT) + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:12551948 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:12551948 + pmid:17403556 - p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane")) + a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) - pmid:17493042 + pmid:17403556 - p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1") + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:17493042 + pmid:17403556 - p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2") + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:17493042 + pmid:17403556 - p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3") + a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:17493042 + pmid:18096814 - p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4") + a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) - pmid:17493042 + pmid:18096814 - p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") + a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) - pmid:17493042 + pmid:20133804 - p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain") + p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) @@ -117209,171 +117406,166 @@

Statements

- pmid:17493042 + pmid:17403556 - p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + a(HBP:"amyloid-beta antibody, NU1") decreases act(a(HBP:"amyloid-beta derived diffusible ligands")) - pmid:17493042 + pmid:17403556 - bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) - pmid:21757739 + pmid:17403556 - a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) + a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) - pmid:21757739 + pmid:17403556 - p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain") + a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:21757739 + pmid:17403556 - p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") + a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) - pmid:21757739 + pmid:28420982 - p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain") + p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes) - pmid:21757739 + pmid:28420982 - a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) + p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21757739 + pmid:28420982 - a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain") + p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:21757739 + pmid:17078951 - a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain") + p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA) - pmid:21757739 + pmid:11943212 - p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2") + p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270") - pmid:21757739 + pmid:28176663 - a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") + p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation a(CHEBI:"D-ribose") - pmid:22033876 + pmid:17403556 - a(HBP:"proline-rich domain") association act(p(FPLX:Actin)) + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:22033876 + pmid:17403556 - a(HBP:"proline-rich domain") association p(INTERPRO:"SH3 domain") + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") - pmid:21757739 + pmid:17403556 - p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain") + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:21757739 + pmid:17403556 - a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198")) + a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) - pmid:21757739 + pmid:17403556 - a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain") + a(CHEBI:LY294002) decreases bp(GO:"signal transduction") - pmid:21757739 + pmid:17403556 - a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain") + a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - - - pmid:21757739 - - p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1") - + - pmid:21757739 + pmid:17403556 - p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain") + complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) @@ -117384,876 +117576,828 @@

Statements

- pmid:27260836 + pmid:27671637 - complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") - pmid:27260836 + pmid:27671637 - p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") - pmid:27260836 + pmid:27671637 - p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") - pmid:27260836 + pmid:27671637 - p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") - pmid:27260836 + pmid:27671637 - p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") - pmid:27260836 + pmid:27671637 - p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") - pmid:11943212 + pmid:27671637 - a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") - pmid:11943212 + pmid:27671637 - a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") - pmid:27260836 + pmid:27671637 - complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) - pmid:26655600 + pmid:27671637 - complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) - pmid:24368848 + pmid:27671637 - p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) - pmid:23407988 + pmid:29202785 - a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) - pmid:23407988 + pmid:29202785 - a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) - pmid:23407988 + pmid:29202785 - a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) - pmid:23407988 + pmid:29202785 - a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:23407988 + pmid:29202785 - a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:23407988 + pmid:29202785 - a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:23407988 + pmid:29202785 - act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:22253473 + pmid:29202785 - a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:23407988 + pmid:29202785 - complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) association p(HGNC:NGFR) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) isA p(HGNC:RAC1) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Microglia) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) - pmid:22142809 + pmid:29202785 - p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) - pmid:27087442 + pmid:29202785 - act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) - pmid:27087442 + pmid:29202785 - act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) - pmid:27796283 + pmid:29202785 - act(p(HGNC:RAC1)) increases bp(GO:"dendritic spine development") + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:22142809 + pmid:29202785 - p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) - pmid:22142809 + pmid:29202785 - p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") - pmid:22142809 + pmid:29202785 - p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") - pmid:22142809 + pmid:29202785 - a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) - pmid:6543144 + pmid:29202785 - complex(GO:microtubule) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) - pmid:10464280 + pmid:29202785 - complex(GO:microtubule) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) - pmid:19491104 + pmid:27671637 - complex(GO:microtubule) association p(HGNC:KIF5B) + a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:10464280 + pmid:27671637 - act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") + a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:10464280 + pmid:27671637 - complex(GO:microtubule) association p(HGNC:PPP2CA) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") - pmid:10464280 + pmid:27671637 - act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") - pmid:18500754 + pmid:27671637 - act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") - pmid:18500754 + pmid:27671637 - complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") - pmid:20133804 + pmid:27671637 - complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) - pmid:1918161 + pmid:27671637 - p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) - pmid:1918161 + pmid:27671637 - p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") - pmid:1918161 + pmid:27671637 - p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") - pmid:1918161 + pmid:27671637 - complex(GO:axon) positiveCorrelation p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) - pmid:26671985 + pmid:27671637 - act(complex(GO:axon)) negativeCorrelation a(HBP:neurotoxicity) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") - pmid:1918161 + pmid:27671637 - complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") - pmid:17187063 + pmid:27671637 - p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") - pmid:17187063 + pmid:27671637 - a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") - pmid:19251756 + pmid:27671637 - a(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:22952452 + pmid:27671637 - a(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") - pmid:6543144 + pmid:27671637 - complex(GO:neurofilament) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) - pmid:2446784 + pmid:27671637 - complex(GO:"polysomal ribosome") association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) - pmid:11812770 + pmid:27671637 - p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) - - - pmid:11812770 + pmid:27671637 - complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) - - - pmid:11812770 + pmid:29202785 - complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) - pmid:18680553 + pmid:29202785 - p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) - pmid:18680553 + pmid:29202785 - p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) - pmid:18680553 + pmid:28528849 - bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) - pmid:18680553 + pmid:27671637 - bp(GO:myelination) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) - pmid:18467332 + pmid:27671637 - p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") - pmid:18467332 + pmid:27671637 - p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) - pmid:18467332 + pmid:27671637 - p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") - pmid:18467332 + pmid:27671637 - p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) - pmid:18467332 + pmid:27671637 - p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) - pmid:22033876 + pmid:27671637 - p(INTERPRO:"SH3 domain") association a(HBP:"proline-rich domain") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") - - - - - pmid:18467332 + pmid:29202785 - p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates") - pmid:18467332 + pmid:29202785 - p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) - pmid:18467332 + pmid:28528849 - p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) - - - - - pmid:18467332 + pmid:29202785 - p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration) - pmid:18467332 + pmid:29202785 - p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) - pmid:18467332 + pmid:29202785 - p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) - pmid:18467332 + pmid:29202785 - p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) - - - - - pmid:18467332 + pmid:29202785 - complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) - pmid:18467332 + pmid:29202785 - p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) - pmid:18467332 + pmid:29202785 - p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:18467332 + pmid:29202785 - p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) - pmid:18467332 + pmid:29202785 - p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:18467332 + pmid:29202785 - p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") - - - pmid:18467332 + pmid:29202785 - p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") - - - - - pmid:19491104 + pmid:29202785 - bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) - pmid:19491104 + pmid:28528849 - p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) - pmid:19491104 + pmid:28528849 - act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau fibrils") - pmid:19491104 + pmid:28528849 - act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau oligomers") - - - - - - - - - - - pmid:10464280 + pmid:28528849 - rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(HBP:"Tau oligomers", var("p.Lys280del")) - - - - - pmid:18500754 + pmid:28528849 - p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") - pmid:19363271 + pmid:28528849 - a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") + p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange bp(GO:"cellular calcium ion homeostasis") - - - - - - - pmid:14612456 + pmid:27671637 - complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - - - - - - - pmid:8391280 + pmid:27671637 - p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") + a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:8391280 + pmid:27671637 - p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) - pmid:8391280 + pmid:27671637 - act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) + p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) @@ -118264,27 +118408,27 @@

Statements

- pmid:8391280 + pmid:27671637 - complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) + a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:8391280 + pmid:27671637 - g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:8391280 + pmid:22833681 - g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + a(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) @@ -118295,205 +118439,198 @@

Statements

- pmid:16176937 + pmid:27671637 - p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") - pmid:16176937 + pmid:27671637 - p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") + p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - - - - - pmid:16176937 + pmid:27671637 - p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) - pmid:16176937 + pmid:27671637 - p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") + p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:16176937 + pmid:27671637 - p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) + p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") - pmid:16176937 + pmid:27671637 - p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:16176937 + pmid:27671637 - p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") + p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") - - - - - pmid:16176937 + pmid:27671637 - p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + a(CHEBI:adenosine) increases act(p(MGI:Adora1)) - pmid:10391244 + pmid:27671637 - p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) - pmid:10391244 + pmid:27671637 - act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + a(CHEBI:adenosine) decreases act(a(GO:presynapse)) - - - - - pmid:10391244 + pmid:27671637 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) + a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") - pmid:10391244 + pmid:21882945 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") + a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:10391244 + pmid:27671637 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT)) + act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) - pmid:10391244 + pmid:27671637 - p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) + act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) - pmid:20133804 + pmid:27671637 - p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) + act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") - pmid:20133804 + pmid:27671637 - p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) + a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) - pmid:20133804 + pmid:27671637 - p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) + a(PUBCHEM:64627) increases act(a(MESH:Neurons)) - pmid:20133804 + pmid:27671637 - p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") + a(PUBCHEM:64627) increases act(a(GO:presynapse)) - + + + pmid:27671637 + + a(PUBCHEM:64627) increases a(GO:"dendritic spine") + - pmid:20133804 + pmid:27671637 - p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) + a(PUBCHEM:64627) decreases a(MESH:Axons) - pmid:20133804 + pmid:27671637 - p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) + a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") - pmid:20133804 + pmid:27671637 - p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) + a(MESH:"BSc 3094") increases act(a(GO:presynapse)) @@ -118504,84 +118641,90 @@

Statements

- pmid:20071522 + pmid:27671637 - complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") - - - - - pmid:2123288 + pmid:27671637 - p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2") + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") - pmid:2123288 + pmid:27671637 - act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) - pmid:2123288 + pmid:27671637 - act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) - pmid:27133022 + pmid:27671637 - act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) - pmid:27133022 + pmid:27671637 - act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2)) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") - + + + pmid:27671637 + + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") + - pmid:2123288 + pmid:27671637 - complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") - + + + pmid:27671637 + + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") + - pmid:2123288 + pmid:27671637 - complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") @@ -118590,1594 +118733,1592 @@

Statements

- - - pmid:2123288 + pmid:27671637 - complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) + composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") - pmid:2833519 + pmid:28784767 - p(HGNC:S100B) association p(HGNC:MAPT) + p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") - pmid:2833519 + pmid:28784767 - p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") - pmid:2833519 + pmid:26751493 - act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18494933 + pmid:28784767 - p(HGNC:S100B) increases act(p(HGNC:AGER)) + p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) - pmid:18494933 + pmid:28784767 - p(HGNC:S100B) directlyIncreases act(p(HGNC:AGER)) + p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates") - pmid:18494933 + pmid:18239272 - p(HGNC:S100B) increases p(FPLX:JNK) + p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") - pmid:18494933 + pmid:18239272 - p(HGNC:S100B) increases p(FPLX:JNK, pmod(Ph)) + p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") - pmid:18494933 + pmid:18239272 - p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") + p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") - pmid:18494933 + pmid:28784767 - p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau epitope, AT8") increases bp(HBP:"Tau aggregates") - - - - - pmid:2833519 + pmid:27087442 - complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25") - pmid:2833519 + pmid:25125464 - act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(Ph)) + p(HBP:"Tau epitope, AT8") positiveCorrelation p(MGI:Crhr1) - pmid:12714745 + pmid:19459590 - g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") + p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:MAPT)) - pmid:12714745 + pmid:19459590 - g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") + p(HBP:"Tau epitope, AT8") decreases act(p(HGNC:MAPT)) - pmid:12714745 + pmid:22833681 - complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) + p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt)) - - - - - pmid:12714745 + pmid:22253473 - composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle") + p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) - pmid:12714745 + pmid:20869593 - composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body") + p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac)) - - - - - - - pmid:12551948 + pmid:20869593 - act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection") + p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) - pmid:21339331 + pmid:19623258 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HBP:"Tau epitope, AT8") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) - pmid:21339331 + pmid:28784767 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates") - pmid:21339331 + pmid:28784767 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:MAPT, var("pGly207Val")) increases bp(HBP:"Tau aggregates") - pmid:21339331 + pmid:28784767 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") - pmid:21339331 + pmid:28784767 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") - pmid:17078951 + pmid:28784767 - p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA) + a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") - pmid:17078951 + pmid:28784767 - p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) + a(HBP:"Tau Protein Secondary Structure, Turn") decreases bp(HBP:"Tau aggregates") - pmid:22072628 + pmid:28784767 - p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn") - pmid:21339331 + pmid:28784767 - p(HGNC:ANXA2) association p(HGNC:MAPT) + act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) - pmid:21339331 + pmid:25673844 - p(HGNC:ANXA2) association a(MESH:"Cell Membrane") + p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") - pmid:21339331 + pmid:25673844 - p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) - - - - - - - pmid:18096814 + pmid:25673844 - a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm)) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) - pmid:18096814 + pmid:25673844 - a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) - pmid:18096814 + pmid:25673844 - a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) - pmid:18096814 + pmid:25673844 - p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) - pmid:21131359 + pmid:25673844 - bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) - pmid:21131359 + pmid:28784767 - bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8") - pmid:21131359 + pmid:29590627 - bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") - pmid:21131359 + pmid:24406748 - bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") - pmid:8226987 + pmid:29590627 - bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:19732809 + pmid:29590627 - bp(MESH:"Hot Temperature") association a(HBP:"O-GlcNAcylation") + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - - - - - pmid:21131359 + pmid:29590627 - a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:21131359 + pmid:29590627 - a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:8985176 + pmid:29590627 - a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) - pmid:28173111 + pmid:28877763 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2) + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:28173111 + pmid:28877763 - r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:28173111 + pmid:28877763 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2) + p(HGNC:MAPT, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:24406748 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) + p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:28173111 + pmid:24406748 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) + p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:28173111 + pmid:24406748 - r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) + p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") - pmid:28173111 + pmid:24406748 - r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) + p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) + a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) - pmid:28173111 + pmid:28420982 - r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) + a(CHEBI:dextran) association a(HBP:"Tau aggregates") - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) + a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) + a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:25887395 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) + a(CHEBI:heparin) decreases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:29988016 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) + a(CHEBI:heparin) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:25887395 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) + a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) - pmid:28173111 + pmid:29988016 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) + a(CHEBI:heparin) increases p(HGNC:MAPT, var("?")) - pmid:28173111 + pmid:29686391 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) + a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:28173111 + pmid:29686391 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) + a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:28173111 + pmid:26751493 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) + a(CHEBI:heparin) association p(HBP:"Tau aggregates") - pmid:28173111 + pmid:27601475 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) + a(CHEBI:heparin) increases p(HBP:"Tau aggregates") - pmid:28173111 + pmid:26751493 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) + a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) + a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) + a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) + a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29686391 - act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:28173111 + pmid:29590627 - complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") - pmid:28173111 + pmid:29590627 - complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1) + a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") - pmid:28173111 + pmid:29590627 - complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2) + a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) - pmid:28173111 + pmid:29590627 - complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a) + a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp) + bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4) + bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1) + bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:24760868 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2) + bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") - pmid:28173111 + pmid:27041503 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + bp(GO:"actin filament polymerization") negativeCorrelation bp(MESH:"Long-Term Potentiation") - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2) + bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") - pmid:28173111 + pmid:29590627 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn) + bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") - pmid:28173111 + pmid:26751493 - act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43) + bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) - pmid:28173111 + pmid:26751493 - r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) + bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + + + + - pmid:28173111 + pmid:29590627 - r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + - pmid:28173111 + pmid:29590627 - r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) + composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28173111 + pmid:22611162 - r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:26631930 - r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:26631930 - r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:26631930 - r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:22611162 - r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(Ph)) - pmid:28173111 + pmid:22611162 - r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) - pmid:28173111 + pmid:22611162 - r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") - pmid:28173111 + pmid:22611162 - r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") - pmid:28173111 + pmid:22611162 - r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") - pmid:28173111 + pmid:22611162 - r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") - pmid:28173111 + pmid:22611162 - r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) increases path(HBP:neurotoxicity) - pmid:28173111 + pmid:22611162 - r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") - pmid:28173111 + pmid:26631930 - r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:28173111 + pmid:26631930 - r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases p(HBP:"4R tau") - pmid:28173111 + pmid:26631930 - p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau") - pmid:28173111 + pmid:26631930 - p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission") + p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory) - pmid:28173111 + pmid:26631930 - bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1) + p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:28173111 + pmid:26631930 - bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:28173111 + pmid:26631930 - p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission") + p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") - pmid:28173111 + pmid:26631930 - r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) - pmid:28173111 + pmid:11606569 - p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) - pmid:28173111 + pmid:11606569 - p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix") + p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif") - pmid:28173111 + pmid:11606569 - complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid) + p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif") - pmid:28173111 + pmid:22611162 - r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:22611162 - p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:22611162 - p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion") + p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:28173111 + pmid:22611162 - r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Val277Met")) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:28173111 + pmid:22611162 - p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + p(HGNC:MAPT, var("p.Val277Met")) increases path(HBP:neurotoxicity) - pmid:28173111 + pmid:22611162 - p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion") + p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") - pmid:28173111 + pmid:22611162 - r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + a(PUBCHEM:25096749) increases bp(GO:locomotion) - pmid:28173111 + pmid:22611162 - p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates") - pmid:28173111 + pmid:22611162 - p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion") + a(HBP:bb14) increases bp(GO:locomotion) - pmid:28173111 + pmid:22611162 - bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1) + a(HBP:cmp16) decreases a(HBP:"Tau fibrils") - pmid:28173111 + pmid:22611162 - bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2) + a(HBP:cmp16) increases bp(GO:locomotion) - pmid:28173111 + pmid:22611162 - bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1) + a(HBP:cmp16) decreases bp(HP:Neurodegeneration) - pmid:28173111 + pmid:24760868 - r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + p(MESH:Actins, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:28173111 + pmid:24760868 - p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + + + + - pmid:28173111 + pmid:24760868 - p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion) + complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) association bp(GO:"long-term synaptic potentiation") - pmid:28173111 + pmid:17187063 - r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration) + + + + - pmid:28173111 + pmid:24760868 - p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") - pmid:28173111 + pmid:24760868 - p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion) + a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") - pmid:28173111 + pmid:24760868 - r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + a(MESH:jasplakinolide) increases p(HGNC:MAPT) - pmid:28173111 + pmid:24760868 - p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + a(MESH:jasplakinolide) increases p(HGNC:GRIA1) - pmid:28173111 + pmid:24760868 - p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion) + a(MESH:jasplakinolide) decreases p(HGNC:FYN) - pmid:25987199 + pmid:24760868 - act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) + a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") - pmid:28173111 + pmid:24760868 - r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") - pmid:28173111 + pmid:24760868 - p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) + + - pmid:25974414 + pmid:24760868 - p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") + complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) association a(MESH:"Dendritic Spines") + + - pmid:25974414 + pmid:29202785 - p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:25974414 + pmid:29202785 - p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) + a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:25974414 + pmid:29202785 - p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") + a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) - pmid:25974414 + pmid:29202785 - p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:doxycycline) decreases p(MGI:Wnt3) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") + p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HBP:"6D tau") decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") + p(HBP:"6D tau") causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HBP:"6D tau") increases act(p(MESH:"Protein Phosphatase 1")) - pmid:26671985 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + p(HBP:"6D tau") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + + - pmid:26671985 + pmid:21734277 - p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity) + act(p(HBP:"6D tau")) association p(HBP:"6D tau", frag("2_18")) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) + p(HBP:"6P tau") decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT) + p(HBP:"6P tau") causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) + act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) + act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) + p(HBP:"6D tau", frag("2_18")) association act(p(HBP:"6D tau")) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + p(HBP:"6D tau", frag("2_18")) association bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) + p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) + p(HBP:"6D tau", frag("2_18")) increases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) + p(HBP:"6D tau", frag("2_18")) causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) + p(HBP:"6D tau", frag("2_18")) decreases p(HBP:"endogenous axoplasmic phosphatases") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) + p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) + p(HBP:"6D tau", frag("2_18")) decreases act(p(MESH:"Glycogen Synthase Kinase 3")) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) + p(HBP:"6D tau", frag("2_18")) association p(HBP:TNT1) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) + act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) + act(p(HBP:"6D tau", frag("2_18"))) association path(MESH:"Alzheimer Disease") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) + a(HBP:"I-2") increases act(p(HBP:"6D tau", frag("2_18"))) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) + a(HBP:"ING-135") increases act(p(HBP:"6D tau", frag("2_18"))) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) + p(HBP:"AT8 tau") decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) + p(HBP:"AT8 tau") causesNoChange bp(GO:"retrograde axonal protein transport") + + - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) + p(HBP:"AT8 tau") causesNoChange act(p(HBP:"6D tau", frag("2_18"))) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) + p(HBP:"AT8 tau", pmod(Ph)) association p(HGNC:MAPT, pmod(Ph)) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) + p(HBP:"AT8 tau", pmod(Ph)) association path(MESH:Tauopathies) - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) + p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport") - pmid:25974414 + pmid:21734277 - p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) + p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:24844691 + pmid:21734277 - p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6)) + p(HBP:TNT1) association p(HBP:"6D tau", frag("2_18")) @@ -120188,657 +120329,659 @@

Statements

- pmid:25974414 + pmid:28528849 - act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HBP:"Tau fibrils", var("p.Lys280del")) - pmid:25974414 + pmid:28528849 - act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") - pmid:25974414 + pmid:28528849 - act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") - pmid:25974414 + pmid:28528849 - act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") - pmid:25974414 + pmid:28528849 - p(HGNC:MAPT, pmod(Ph, Thr, 17)) isA p(HGNC:MAPT) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") - pmid:25974414 + pmid:28528849 - act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) - pmid:16566606 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) - pmid:21210655 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS)) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(Ph)) + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) - pmid:16816118 + pmid:28528849 - a(CHEBI:peroxynitrite) increases bp(GO:"neurofibrillary tangle assembly") + p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") - pmid:16566606 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) - pmid:16566606 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) - pmid:16566606 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) - pmid:16566606 + pmid:28528849 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) - pmid:27314526 + pmid:28528849 - a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") + p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cellular calcium ion homeostasis") - pmid:27314526 + pmid:28528849 - a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:16566606 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:22057784 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:22057784 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) - pmid:22057784 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") + p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:17050703 + pmid:28528849 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) - - - pmid:16566606 - - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments") - + + + - pmid:16566606 + pmid:29238289 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) + p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) - pmid:26671985 + pmid:23702978 - a(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon)) + tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) - pmid:26671985 + pmid:23702978 - p(HBP:"phosphatase-activating domain") positiveCorrelation act(a(HBP:"Tau oligomers")) + tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) - pmid:26671985 + pmid:28528849 - p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) + p(HGNC:DBN1) increases bp(GO:"synapse assembly") - pmid:26671985 + pmid:28528849 - p(HBP:"phosphatase-activating domain") decreases act(complex(GO:axon)) + act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") - pmid:26671985 + pmid:28528849 - p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") - pmid:26671985 + pmid:23528736 - p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport") + p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:27260838 + pmid:23528736 - p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1") + p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260838 + pmid:23528736 - p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2") + p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260838 + pmid:23528736 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:pretangles) + p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pmid:23528736 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau") + p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27373205 + pmid:23528736 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21734277 + pmid:23528736 - p(HBP:"phosphatase-activating domain") directlyIncreases act(p(HGNC:PPP1CA)) + p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") - - - pmid:26671985 - - p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) - + + + + + + + - pmid:24869773 + pmid:23528736 - p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT) + composite(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) - pmid:24869773 + pmid:14612456 - p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT) + p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) - pmid:24869773 + pmid:14612456 - p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) - pmid:24869773 + pmid:23528736 - p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) + a(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) - pmid:22033876 + pmid:23528736 - p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) + a(CHEBI:"lithium atom") increases bp(GO:autophagy) - pmid:24869773 + pmid:23528736 - p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) + a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) - pmid:22033876 + pmid:23528736 - p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2") + a(CHEBI:"lithium atom") decreases a(HP:"Neurofibrillary tangles") - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT) + r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(MGI:Tfeb) increases p(MGI:Lamp1) - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT) + p(MGI:Tfeb) increases p(MGI:Ctsa) - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(MGI:Tfeb) increases p(MGI:Ctsb) - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT) + p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT) + p(MGI:Tfeb) increases a(HBP:"Tau fibrils") - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(MGI:Tfeb) increases a(HBP:"Tau fibrils") - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT) + p(MGI:Tfeb) increases a(HBP:"Tau fibrils") - pmid:24869773 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils")) + + - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 163)) association p(HGNC:MAPT) + p(MGI:Tfeb) increases bp(MESH:Phagocytosis) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf a(HBP:"proline-rich domain") + p(MGI:Tfeb) increases r(MGI:Lamp1) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 174)) association p(HGNC:MAPT) + p(MGI:Tfeb) increases bp(MESH:Proteolysis) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf a(HBP:"proline-rich domain") + p(MGI:Tfeb) causesNoChange p(MGI:Phf1) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 180)) association p(HGNC:MAPT) + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf a(HBP:"proline-rich domain") + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 254)) association p(HGNC:MAPT) + p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph)) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1") + p(MGI:Tfeb) decreases p(MGI:Mapt) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Ub, Lys, 254)) association p(HGNC:MAPT) + p(MGI:Tfeb) decreases path(MESH:Tauopathies) - pmid:8391280 + pmid:30108137 - p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") + p(MGI:Tfeb) decreases path(MESH:Gliosis) - pmid:22033876 + pmid:30108137 - p(HGNC:MAPT, pmod(Me, Lys, 267)) association p(HGNC:MAPT) + bp(MESH:Pinocytosis) increases act(a(MESH:Astrocytes)) - pmid:22033876 + pmid:25887395 - p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1") + p(HGNC:MAPT, frag("243_375")) increases a(HBP:"Tau fibrils") @@ -120847,9 +120990,9 @@

Statements

- pmid:23943618 + pmid:25887395 - complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) + complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) @@ -120858,329 +121001,318 @@

Statements

- pmid:23943618 + pmid:25887395 - complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(HBP:"Tau aggregates") - pmid:22764226 + pmid:25887395 - act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) - pmid:22764226 + pmid:25887395 - act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") + + - pmid:22764226 + pmid:25887395 - act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:22764226 + pmid:25887395 - act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") - pmid:22764226 + pmid:25887395 - act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") - pmid:22764226 + pmid:29988016 - act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) + p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + - pmid:22764226 + pmid:22817713 - act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) + complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") - pmid:22764226 + pmid:29988016 - a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) + a(PUBCHEM:100984821) increases a(HBP:"Tau aggregates") - pmid:22764226 + pmid:21882945 - a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) + a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) - pmid:22764226 + pmid:21882945 - p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1") + a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates") - - - - - pmid:25143394 + pmid:26751493 - p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") - pmid:25681682 + pmid:21882945 - bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) + a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") - pmid:25681682 + pmid:29191965 - a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) + a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") - pmid:24183963 + pmid:29191965 - a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) + a(HBP:"Phenylthiazolyl-hydrazide") positiveCorrelation bp(GO:locomotion) - pmid:24183963 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates") - pmid:26095350 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) + a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates") - pmid:26095350 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates") - pmid:22798221 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin)) + a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates") - pmid:22798221 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin)) + a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates") - pmid:8063802 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") decreases act(p(HGNC:MAPT)) + a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) - pmid:8063802 + pmid:21882945 - a(CHEBI:"advanced glycation end-product") increases bp(GO:"neurofibrillary tangle assembly") + p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:24183963 + pmid:21882945 - p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) - pmid:24183963 + pmid:21882945 - p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:25987199 + pmid:21882945 - act(p(HGNC:GLP1R)) decreases bp(MESH:"Oxidative Stress") + a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) - - - pmid:25987199 - - act(p(HGNC:GLP1R)) increases act(a(GO:mitochondrion)) - + + + - pmid:23531502 + pmid:21882945 - a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif") + a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) - pmid:23531502 + pmid:21882945 - a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly") + a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:23531502 + pmid:21882945 - a(CHEBI:cinnamaldehyde) causesNoChange bp(GO:"microtubule polymerization") + a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) - pmid:23531502 + pmid:21882945 - a(CHEBI:cinnamaldehyde) decreases act(a(CHEBI:"hydrogen peroxide")) + a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + - pmid:23531502 + pmid:21882945 - p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif") + complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) - pmid:25031639 + pmid:21882945 - p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle") + p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90)) - - - pmid:23531502 - - a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif") - + - pmid:23531502 + pmid:21882945 - a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly") + a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) - pmid:23531502 + pmid:21882945 - a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) + a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) - - - pmid:23531502 - - a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) - + @@ -121190,634 +121322,699 @@

Statements

- pmid:23531502 + pmid:21882945 - complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein)) + a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) - pmid:23531502 + pmid:21882945 - act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) - - - pmid:17082178 - - a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") - + - pmid:23531502 + pmid:21882945 - act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid") + a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) - pmid:23531502 + pmid:21882945 - act(a(CHEBI:acrolein)) decreases a(MESH:Neurons) + a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) - - - pmid:23531502 - - act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") - + - pmid:26655600 + pmid:21882945 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:celastrol) association act(p(FPLX:HSP90)) - pmid:26655600 + pmid:29311797 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) + a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) - pmid:26655600 + pmid:29311797 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:celastrol) decreases p(HGNC:MAPT) - - - pmid:26655600 - - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") - + + + + + + + + + - pmid:26655600 + pmid:21882945 - p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + + + + - pmid:26655600 + pmid:21882945 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:26655600 + pmid:14963027 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) - pmid:26655600 + pmid:14963027 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + + + + + + + + + + + + - pmid:26655600 + pmid:21882945 - p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + + + + + + + + + + - pmid:26655600 + pmid:20071522 - p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly") + complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) + + + + - pmid:26655600 + pmid:20071522 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:26304819 + pmid:20071522 - a(CHEBI:glyceraldehyde) decreases bp(GO:"canonical glycolysis") + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:26304819 + pmid:20071522 - a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE") + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:26304819 + pmid:29311797 - a(CHEBI:glyceraldehyde) decreases p(HGNC:APP, frag("672_713")) + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau aggregates") + + + + - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) + complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) + complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) - pmid:26304819 + pmid:21882945 - a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) + complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") + + - pmid:19251756 + pmid:21882945 - bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") + complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) + + + + + + + + + + + + - pmid:26304819 + pmid:21882945 - r(HGNC:GAPDH) association bp(GO:"apoptotic process") + complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) + + + + + + - pmid:26304819 + pmid:21882945 - a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product") + complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + + + + - pmid:26304819 + pmid:21882945 - p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") + complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + + + + - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") + bp(GO:"cellular senescence") association bp(GO:"cell cycle") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214)) + bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) + bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") - pmid:28176663 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) + bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") - pmid:28176663 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + bp(GO:"cellular senescence") association p(MGI:Cdkn2a) - pmid:28176663 + pmid:30126037 - a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287)) + bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") - pmid:26095350 + pmid:30126037 - a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306)) + bp(GO:"cellular senescence") increases bp(GO:"neuron death") - pmid:19517062 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates") + bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") - pmid:19517062 + pmid:30126037 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation)) + bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") - pmid:28176663 + pmid:30126037 - a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") + bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) - pmid:26095350 + pmid:30126037 - p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") + bp(GO:"cellular senescence") association path(MESH:Tauopathies) - pmid:26095350 + pmid:30126037 - p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") + bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") - pmid:26095350 + pmid:30126037 - p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) + bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) - - - - - pmid:26095350 + pmid:30126037 - p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) + bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) + bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) + bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) + bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + bp(GO:"cellular senescence") association bp(GO:"inflammatory response") - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) + bp(GO:"cellular senescence") increases bp(HBP:HBP00037) - pmid:22798221 + pmid:29221819 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) + p(MGI:Cdkn2a) association bp(GO:"cellular senescence") - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") + p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") - pmid:22798221 + pmid:30126037 - a(CHEBI:methylglyoxal) increases p(HGNC:AGER) + p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:19251756 + pmid:30126037 - a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") - pmid:17082178 + pmid:30126037 - a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") + path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(MGI:Glb1) positiveCorrelation a(HP:brain) - pmid:22798221 + pmid:30126037 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + a(HP:brain) positiveCorrelation p(MGI:Glb1) - pmid:19251756 + pmid:30126037 - act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:"D-glyceraldehyde 3-phosphate"))) + bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") + path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) - pmid:19251756 + pmid:30126037 - act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(HBP:Neurodegeneration) + path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") @@ -121826,926 +122023,868 @@

Statements

- - - pmid:19251756 + pmid:30126037 - act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") - - - - - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") - pmid:19251756 + pmid:30126037 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") - - - - - pmid:19251756 + pmid:30126037 - complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta") + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) - pmid:19251756 + pmid:30126037 - complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle") + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) - pmid:18494933 + pmid:30126037 - p(FPLX:JNK, pmod(Ph)) positiveCorrelation act(p(FPLX:JNK)) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) - pmid:16630055 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) - pmid:22833681 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) - pmid:22833681 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") - pmid:22833681 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) - pmid:22833681 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") - pmid:22833681 + pmid:30126037 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) - pmid:22833681 + pmid:28408124 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates") + a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:19732809 + pmid:28408124 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:16630055 + pmid:28408124 - path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:16630055 + pmid:28408124 - path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph)) + a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:16630055 + pmid:28408124 - path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) + a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:12578227 + pmid:28408124 - p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:12578227 + pmid:28408124 - p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13") + a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:12578227 + pmid:28408124 - r(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) + a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:12578227 + pmid:28408124 - p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT) - pmid:9099822 + pmid:28408124 - act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:12578227 + pmid:28408124 - p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13") + a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:10537045 + pmid:28408124 - p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) + a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:10537045 + pmid:28408124 - p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:10537045 + pmid:28408124 - act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region") + a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:11089576 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:11089576 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:11738469 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:8985134 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:11738469 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT) - pmid:8985134 + pmid:28408124 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph)) - - - - - pmid:10537045 + pmid:28408124 - complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") + a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:10537045 + pmid:28408124 - a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)") + a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:10537045 + pmid:28408124 - a(HBP:maitotoxin) increases act(p(HGNC:TGM2)) + a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:22057784 + pmid:28408124 - p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:17768677 + pmid:28408124 - p(MGI:Mapt, pmod(HBP:nitration, Tyr, 488)) causesNoChange act(p(MGI:Mapt)) + a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph)) - pmid:17768677 + pmid:28408124 - p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) + a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) - pmid:16816118 + pmid:28408124 - a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) + a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:16816118 + pmid:28408124 - a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome")) + a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) - pmid:16816118 + pmid:28408124 - p(RGD:Mapt, pmod(HBP:nitration)) negativeCorrelation act(p(HBP:"20 S Proteasome")) + a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - - - pmid:27796283 + pmid:28408124 - act(p(HGNC:RHOA)) decreases bp(GO:"dendritic spine development") + a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:27796283 + pmid:28408124 - act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") + a(HBP:"Tau antibody, Tau46") association p(HGNC:MAPT) - pmid:27796283 + pmid:25331948 - act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") - pmid:27796283 + pmid:25331948 - bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") - pmid:27796283 + pmid:25331948 - p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1)) + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") - - - pmid:27796283 + pmid:25331948 - p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") - pmid:27796283 + pmid:25331948 - p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7")) + a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) - - - pmid:27796283 + pmid:25331948 - act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1)) + a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) - pmid:27796283 + pmid:25331948 - p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) + a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) - pmid:27796283 + pmid:25331948 - p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7)) + a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) - - - pmid:27796283 + pmid:25331948 - act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) + a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) - pmid:27796283 + pmid:25331948 - complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) + a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) - pmid:27796283 + pmid:25331948 - act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) - pmid:27796283 + pmid:25331948 - act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) - pmid:27796283 + pmid:25331948 - act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - - - pmid:27796283 + pmid:25331948 - p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") + a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) - pmid:27796283 + pmid:25331948 - p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") + a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") - - - - - pmid:27796283 + pmid:25331948 - complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 199)) - pmid:27796283 + pmid:25331948 - p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV)) + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) - - - - - - - pmid:29121589 + pmid:25331948 - complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly)) + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Thr, 205)) - pmid:29121589 + pmid:25331948 - p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) - pmid:29121589 + pmid:25331948 - p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2)) + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) - pmid:29121589 + pmid:25331948 - p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(Ph)) - pmid:29121589 + pmid:25331948 - p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) - pmid:29121589 + pmid:25331948 - p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27") + a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) - - - - - - - pmid:29121589 + pmid:25331948 - complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(UbPoly)) + a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) - pmid:29121589 + pmid:25331948 - p(HGNC:DPYSL2, pmod(Ph)) negativeCorrelation a(CHEBI:"dimethyl fumarate") + a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) - - - pmid:24401760 + pmid:25331948 - a(HBP:Astrogliosis) biomarkerFor path(MESH:"Alzheimer Disease") + a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") - pmid:29121589 + pmid:25331948 - r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) - pmid:29121589 + pmid:25331948 - r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:27807169 + pmid:25331948 - p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:27807169 + pmid:25331948 - p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:27807169 + pmid:25331948 - p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse) + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:21489990 + pmid:29221819 - act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) + p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) - pmid:21489990 + pmid:25331948 - act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404)) + p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk) - pmid:21489990 + pmid:26095350 - act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) + p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") - - - - - - - - - pmid:7514173 + pmid:28877763 - a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) - pmid:7514173 + pmid:25331948 - a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin)) + p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) - pmid:7514173 + pmid:28877763 - a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) - pmid:7514173 + pmid:25331948 - a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin)) + p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) + + + + - pmid:7514173 + pmid:25331948 - a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin)) + composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) + + + + - pmid:7514173 + pmid:25331948 - a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) - pmid:7514173 + pmid:25331948 - a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) - pmid:7514173 + pmid:25331948 - a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) - pmid:7514173 + pmid:25331948 - a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) - pmid:17078951 + pmid:25331948 - p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) - pmid:17078951 + pmid:25331948 - p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) - pmid:22072628 + pmid:25331948 - p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) - - - - - - - - - - - - - - - - @@ -122753,944 +122892,933 @@

Statements

- pmid:9089387 + pmid:25331948 - p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) + composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) - pmid:9089387 + pmid:25331948 - act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) + composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) - - - pmid:22102280 + pmid:25331948 - a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) - pmid:22102280 + pmid:25331948 - a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) - pmid:22102280 + pmid:25331948 - a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) - pmid:10998059 + pmid:25331948 - a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:SYK) increases a(CHEBI:"amyloid-beta") - pmid:10998059 + pmid:25331948 - a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:SYK)) increases a(CHEBI:"amyloid-beta") - pmid:10998059 + pmid:25331948 - a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) + act(p(HGNC:SYK)) decreases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) - pmid:10998059 + pmid:25331948 - a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) + act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta")) - pmid:11013232 + pmid:28877763 - a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:SYK) regulates p(HBP:"sAPP-beta") - pmid:10998059 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph)) + act(p(HGNC:SYK)) increases r(HGNC:BACE1) - pmid:26400044 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph)) + act(p(HGNC:SYK)) increases p(HGNC:BACE1) - pmid:26400044 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph)) + p(HGNC:SYK) regulates p(HGNC:BACE1) - pmid:24808823 + pmid:25331948 - p(MGI:Cdk5) negativeCorrelation bp(GO:learning) + act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(Ph)) - pmid:27087442 + pmid:25331948 - p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1) + p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:27087442 + pmid:28877763 - p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b)) + p(HGNC:SYK) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:27087442 + pmid:28877763 - p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition) + act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:27087442 + pmid:28877763 - p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons)) + act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175)) + p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176)) + act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:14642273 + pmid:26631930 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178)) + p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - pmid:14642273 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195)) + act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + p(HGNC:SYK) increases act(p(HGNC:GSK3B)) - pmid:14642273 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") + act(p(HGNC:SYK)) positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) - pmid:14642273 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217)) + p(HGNC:SYK) decreases act(p(FPLX:PKA)) - pmid:14642273 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220)) + p(HGNC:SYK) decreases act(p(FPLX:PKA)) - pmid:14642273 + pmid:25331948 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) + p(HGNC:SYK) increases p(FPLX:PKA, pmod(Ph, Tyr, 330)) - pmid:14642273 + pmid:29191965 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239)) + p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + act(p(HGNC:SYK)) positiveCorrelation bp(GO:"microglial cell activation") - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400)) + act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") - pmid:14642273 + pmid:28877763 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403)) + act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") - - - pmid:8702879 + pmid:28877763 - p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) + act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") - - - pmid:8702879 + pmid:28877763 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) + p(HGNC:SYK) association a(HBP:"Tau aggregates") - - - - - pmid:8702879 + pmid:28877763 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) + p(HGNC:SYK) association a(HBP:"Tau aggregates") - - - pmid:8702879 + pmid:28877763 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) + p(HGNC:SYK) positiveCorrelation a(HBP:"Tau aggregates") - - - pmid:8702879 + pmid:28877763 - p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) + act(p(HGNC:SYK)) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:8702879 + pmid:28877763 - p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - pmid:26400044 + pmid:28877763 - p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - - - pmid:26400044 + pmid:28877763 - p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - - - - - + + + pmid:28877763 + + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded)) + - pmid:26400044 + pmid:28877763 - complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") + act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:misfolded)) - pmid:8726973 + pmid:28877763 - a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5)) + p(HGNC:SYK) increases p(HGNC:MAPT) - pmid:8726973 + pmid:28877763 - a(HBP:olomoucine) decreases act(p(HGNC:CDK5)) + p(HGNC:SYK) causesNoChange r(HGNC:MAPT) + + - pmid:18239272 + pmid:26501932 - p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SYK) partOf a(HBP:pretangles) - pmid:25673844 + pmid:26501932 - p(HGNC:CSNK1D) isA p(FPLX:CSNK1) + p(HGNC:SYK) partOf a(HBP:"GVD bodies") - pmid:18239272 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) + act(p(HGNC:SYK)) negativeCorrelation p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:18239272 + pmid:23702978 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) - pmid:18239272 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) - pmid:18239272 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) - pmid:18239272 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(PUBCHEM:71656932) causesNoChange a(CHEBI:"amyloid-beta") - pmid:18239272 + pmid:25331948 - p(HGNC:TTBK1) association a(HBP:pretangles) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) - pmid:20096481 + pmid:25331948 - p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) - pmid:20096481 + pmid:25331948 - p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) - pmid:21548880 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:CDK5R1) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta") - pmid:21548880 + pmid:25331948 - p(HGNC:TTBK1) positiveCorrelation act(p(ECCODE:"3.4.22.52")) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) - pmid:21548880 + pmid:25331948 - p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2B) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta")) - pmid:21548880 + pmid:25331948 - p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2D) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily") + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Tyr, 18)) - pmid:25673844 + pmid:25331948 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) - pmid:25473830 + pmid:25331948 - p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) - pmid:25473830 + pmid:25331948 - p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) - pmid:23687953 + pmid:25331948 - act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(Ph, Tyr, 231)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease") + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:21548880 + pmid:25331948 - g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs2651206) association g(HGNC:TTBK1) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - pmid:21548880 + pmid:25331948 - g(DBSNP:rs2651206) isA g(HGNC:TTBK1) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease") + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs10807287) association g(HGNC:TTBK1) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(Ph, Tyr, 231)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease") + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(Ph, Ser, 473)) - pmid:20096481 + pmid:25331948 - g(DBSNP:rs7764257) association g(HGNC:TTBK1) + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(Ph)) + + + + - pmid:20096481 + pmid:28877763 - g(HGNC:TTBK1) association g(DBSNP:rs2651206) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK) - pmid:20096481 + pmid:28877763 - g(HGNC:TTBK1) association g(DBSNP:rs10807287) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK)) - pmid:20096481 + pmid:28877763 - g(HGNC:TTBK1) association g(DBSNP:rs7764257) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) - pmid:2820993 + pmid:26751493 - act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21548880 + pmid:26631930 - p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21548880 + pmid:26631930 - p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) association a(HBP:"paired helical filaments") - pmid:21548880 + pmid:28877763 - p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin)) + p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) - pmid:21548880 + pmid:28877763 - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) + p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) - pmid:21548880 + pmid:25331948 - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) + p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) - pmid:21548880 + pmid:25331948 - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) + p(FPLX:PKA, pmod(Ph, Tyr, 330)) decreases act(p(FPLX:PKA)) - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + p(HGNC:AK1) positiveCorrelation p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) + p(HGNC:AK1) positiveCorrelation p(HGNC:APP) - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin)) + p(HGNC:AK1) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + act(p(HGNC:AK1)) association a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) + p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 202))) - pmid:21548880 + pmid:22419736 - p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin)) + p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 396))) - pmid:21548880 + pmid:22419736 - p(HGNC:CDK5R1) increases act(p(HGNC:CDK5)) + p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 404))) - pmid:26118667 + pmid:22419736 - p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) + p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Ser, 231))) - pmid:26118667 + pmid:22419736 - p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25") + p(HGNC:AK1) decreases act(p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 235))) - - - pmid:21548880 + pmid:22419736 - act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(HGNC:TTBK1) + p(HGNC:AK1) increases p(HBP:"Tau aggregates") - pmid:21548880 + pmid:22419736 - p(HGNC:GRIN2D) negativeCorrelation p(HGNC:TTBK1) + p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) - pmid:25673844 + pmid:22419736 - p(HGNC:VRK2) isA p(HBP:"CK1 superfamily") + p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:25673844 + pmid:22419736 - p(HGNC:VRK3) isA p(HBP:"CK1 superfamily") + p(HGNC:AK1) regulates p(ECCODE:"2.7.11.31") - pmid:25673844 + pmid:22419736 - p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) + p(HGNC:AK1) regulates p(HGNC:GSK3B) - pmid:25673844 + pmid:22419736 - p(HGNC:CSNK1E) isA p(FPLX:CSNK1) + p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") - pmid:25673844 + pmid:22419736 - p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) + p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") - pmid:25673844 + pmid:22419736 - p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) + p(HGNC:AK1) increases act(p(HGNC:MAPT)) - pmid:25673844 + pmid:22419736 - p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) + p(HGNC:APP, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(HGNC:AK1) @@ -123707,1175 +123835,1196 @@

Statements

- - - pmid:25673844 + pmid:22419736 - p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1) + act(p(ECCODE:"2.7.11.31")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + + - pmid:25673844 + pmid:22419736 - p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84)) + p(ECCODE:"2.7.11.31") decreases p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) - - - pmid:27607061 + pmid:22419736 - surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A)) + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - pmid:26323690 + pmid:22419736 - p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) - - - pmid:26323690 + pmid:22419736 - act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) - pmid:26323690 + pmid:22419736 - bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 396)) - pmid:26323690 + pmid:22419736 - p(HGNC:CEP164) association p(HGNC:TTBK2) + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) - pmid:26323690 + pmid:22419736 - p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2)) + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) - - - pmid:26323690 + pmid:22419736 - p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + p(ECCODE:"2.7.11.31") decreases act(p(HGNC:GSK3B)) - pmid:26323690 + pmid:22419736 - p(HGNC:MAPRE1) association p(HGNC:TTBK2) + p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph)) + + - pmid:26323690 + pmid:22419736 - p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) + p(HBP:"AK1 R132A") causesNoChange p(ECCODE:"2.7.11.31", pmod(Ph, Thr, 172)) - - - + + + pmid:22419736 + + a(HBP:acadesine) increases act(p(ECCODE:"2.7.11.31")) + - pmid:26323690 + pmid:22419736 - complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) + path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph)) - pmid:26323690 + pmid:30640040 - p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + act(p(HGNC:FLT1)) increases a(HBP:"Tau aggregates") - pmid:24808823 + pmid:30640040 - p(MGI:Ttbk1) negativeCorrelation bp(GO:learning) + act(p(HGNC:KDR)) increases a(HBP:"Tau aggregates") - pmid:24808823 + pmid:30640040 - p(MGI:Ttbk1) increases a(HBP:pretangles) + p(HGNC:KDR) association a(PUBCHEM:11154925) - pmid:24808823 + pmid:30640040 - p(MGI:Ttbk1) increases bp(GO:"neuron death") + p(HGNC:KDR) association a(PUBCHEM:11234052) - pmid:24808823 + pmid:30640040 - surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning) + act(p(FPLX:TGFB)) increases a(HBP:"Tau aggregates") - - - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + act(p(FPLX:HDAC)) decreases a(HBP:"Tau aggregates") - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(FPLX:HDAC) association a(PUBCHEM:9865515) - pmid:11943212 + pmid:21427723 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(PUBCHEM:9804992) increases a(HBP:"Tau aggregates") - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) + a(PUBCHEM:9865515) increases a(HBP:"Tau aggregates") - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(PUBCHEM:9865515) association p(FPLX:HDAC) - pmid:11943212 + pmid:30640040 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(PUBCHEM:4261) increases a(HBP:"Tau aggregates") - pmid:11943212 + pmid:30640040 - p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2") + a(PUBCHEM:4261) association p(HGNC:HDAC1) - pmid:26751493 + pmid:30640040 - p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") + a(PUBCHEM:4261) association p(HGNC:HDAC3) - pmid:26751493 + pmid:30640040 - p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") + a(PUBCHEM:24756910) increases a(HBP:"Tau aggregates") - pmid:11943212 + pmid:30640040 - p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") - pmid:11943212 + pmid:30640040 - p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration") + a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") - - - pmid:22692785 + pmid:30640040 - p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc) + a(PUBCHEM:24756910) association p(HGNC:EGFR) - pmid:23666762 + pmid:30640040 - p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:24756910) association p(HGNC:ERBB2) - pmid:22156579 + pmid:30640040 - p(HGNC:MARK4) increases a(HBP:"Tau epitope, 12E8") + a(PUBCHEM:448537) increases a(HBP:"Tau aggregates") - pmid:22156579 + pmid:30640040 - p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) + a(PUBCHEM:448537) association p(FPLX:ESR) - pmid:22156579 + pmid:30640040 - p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) + a(PUBCHEM:5318517) increases a(HBP:"Tau aggregates") - pmid:22156579 + pmid:30640040 - p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") + a(PUBCHEM:5318517) association p(FPLX:NFkappaB) - pmid:22156579 + pmid:30640040 - p(HGNC:MARK4) negativeCorrelation a(GO:synapse) + a(PUBCHEM:5318517) association p(FPLX:Actin) - pmid:22692785 + pmid:30640040 - p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4) + a(PUBCHEM:71295844) increases a(HBP:"Tau aggregates") - pmid:22692785 + pmid:30640040 - p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:71295844) association p(HGNC:GSK3A) - pmid:22156579 + pmid:30640040 - p(INTERPRO:"Kinase associated domain 1 (KA1)") positiveCorrelation act(a(HBP:"amyloid-beta oligomers")) + a(PUBCHEM:71295844) association p(HGNC:GSK3B) - pmid:22156579 + pmid:30640040 - act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:42640) increases a(HBP:"Tau aggregates") - pmid:22156579 + pmid:30640040 - act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + a(PUBCHEM:42640) association p(HGNC:MDM4) - pmid:16973293 + pmid:30640040 - p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") + a(PUBCHEM:2746) increases a(HBP:"Tau aggregates") - pmid:16973293 + pmid:30640040 - p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) + a(PUBCHEM:2746) association p(FPLX:"HDAC_I") - pmid:16973293 + pmid:30640040 - bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)") + a(PUBCHEM:71729974) increases a(HBP:"Tau aggregates") - pmid:23666762 + pmid:30640040 - p(HBP:"Tau antibody, AGG5759") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") - pmid:23666762 + pmid:30640040 - p(HBP:"Tau antibody, Tau-13") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:53340666) increases a(HBP:"Tau aggregates") - pmid:23666762 + pmid:30640040 - p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin)) + a(PUBCHEM:53340666) association p(HGNC:HDAC6) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713"))) + a(PUBCHEM:11154925) decreases a(HBP:"Tau aggregates") - pmid:27094130 + pmid:30640040 - act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713"))) + a(PUBCHEM:11154925) association p(HGNC:KDR) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711"))) + a(PUBCHEM:4521392) decreases a(HBP:"Tau aggregates") - pmid:27094130 + pmid:30640040 - act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711"))) + a(PUBCHEM:4521392) association p(HGNC:TGFBR1) - - - + + + pmid:30640040 + + a(PUBCHEM:11234052) decreases a(HBP:"Tau aggregates") + - pmid:27094130 + pmid:30640040 - act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) + a(PUBCHEM:11234052) association p(HGNC:KDR) - pmid:27068745 + pmid:30640040 - act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") + a(PUBCHEM:46209426) decreases a(HBP:"Tau aggregates") - pmid:25899010 + pmid:30640040 - p(HGNC:DAPK1) positiveCorrelation a(HBP:Excitotoxicity) + a(PUBCHEM:46209426) association p(FPLX:ROCK) - pmid:25899010 + pmid:30640040 - p(HGNC:DAPK1) negativeCorrelation p(HGNC:PIN1) + a(PUBCHEM:6321424) decreases a(HBP:"Tau aggregates") - pmid:27795443 + pmid:30640040 - act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) + a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) - pmid:27795443 + pmid:30640040 - act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") + a(PUBCHEM:11570805) decreases a(HBP:"Tau aggregates") - pmid:24853415 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) + a(PUBCHEM:11570805) association p(HGNC:MAPK14) - pmid:24853415 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:156422) decreases a(HBP:"Tau aggregates") - pmid:23948915 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(PUBCHEM:156422) association p(HGNC:MAPK14) - pmid:24853415 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(PUBCHEM:9880) decreases a(HBP:"Tau aggregates") - pmid:23948915 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(PUBCHEM:9880) decreases act(p(HGNC:AR)) - pmid:24853415 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(PUBCHEM:3033825) decreases a(HBP:"Tau aggregates") - pmid:23948915 + pmid:30640040 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(PUBCHEM:3033825) association p(HGNC:TNC) - pmid:24853415 + pmid:30640040 - p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) + a(PUBCHEM:5311272) decreases a(HBP:"Tau aggregates") - pmid:21311567 + pmid:30640040 - p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) + a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) - pmid:21311567 + pmid:30640040 - p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) + a(PUBCHEM:49806720) decreases a(HBP:"Tau aggregates") - pmid:21311567 + pmid:30640040 - p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") + a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("637_1423")) association p(HGNC:APP) + a(PUBCHEM:9839311) decreases a(HBP:"Tau aggregates") - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) + a(PUBCHEM:9839311) association p(HGNC:SELE) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("848_1423")) association p(HGNC:APP) + a(PUBCHEM:9839311) association p(HGNC:ICAM1) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) + a(PUBCHEM:447966) decreases a(HBP:"Tau aggregates") - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("1271_1423")) association p(HGNC:APP) + a(PUBCHEM:447966) association p(HGNC:TGFBR1) - pmid:27094130 + pmid:30640040 - p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") + a(PUBCHEM:11655119) decreases a(HBP:"Tau aggregates") - pmid:27094130 + pmid:30640040 - p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) + a(PUBCHEM:11655119) association p(HGNC:TGFBR1) - pmid:27094130 + pmid:30640040 - p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) + a(PUBCHEM:11655119) association p(HGNC:TGFBR2) - pmid:27068745 + pmid:30640040 - p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) + a(PUBCHEM:10435235) decreases a(HBP:"Tau aggregates") - pmid:27068745 + pmid:30640040 - p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(kin)) + a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) - pmid:27068745 + pmid:30640040 - p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") + a(PUBCHEM:5833) decreases a(HBP:"Tau aggregates") - - - pmid:27068745 + pmid:30640040 - p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") + a(PUBCHEM:5833) association p(HGNC:AR) - pmid:27068745 + pmid:30640040 - p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) + a(PUBCHEM:10341154) decreases a(HBP:"Tau aggregates") - pmid:27068745 + pmid:30640040 - p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met")) + a(PUBCHEM:10341154) association p(HGNC:MAPK14) - pmid:27068745 + pmid:30640040 - act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) + a(PUBCHEM:4878) decreases a(HBP:"Tau aggregates") - pmid:27068745 + pmid:30640040 - act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) + a(PUBCHEM:4878) association p(HGNC:LCK) - pmid:27068745 + pmid:30640040 - act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) + a(PUBCHEM:4878) association p(HGNC:FYN) - pmid:27068745 + pmid:30640040 - act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) + p(HGNC:HDAC1) association a(PUBCHEM:4261) - pmid:27068745 + pmid:30640040 - act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) + p(HGNC:HDAC3) association a(PUBCHEM:4261) - pmid:27068745 + pmid:28771976 - p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK)) + p(HGNC:HDAC3) increases act(a(CL:0000129)) - pmid:27795443 + pmid:28771976 - act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") + p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") - pmid:27795443 + pmid:28771976 - act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) + p(HGNC:HDAC3) decreases a(GO:"dendritic spine") - pmid:27133022 + pmid:30640040 - p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) + p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) - pmid:27133022 + pmid:30640040 - p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) + p(FPLX:"HDAC_I") association a(PUBCHEM:2746) - pmid:27133022 + pmid:30640040 - p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM)) + p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) - pmid:27133022 + pmid:30640040 - act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + p(HGNC:ERBB2) association a(PUBCHEM:24756910) - pmid:25995053 + pmid:30640040 - p(MGI:Dapk1) association p(MGI:Mapt) + p(FPLX:ESR) association a(PUBCHEM:448537) - pmid:25995053 + pmid:30640040 - p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt)) + p(FPLX:Actin) association a(PUBCHEM:5318517) - pmid:25995053 + pmid:22033876 - p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) + act(p(FPLX:Actin)) association a(HBP:"proline-rich domain") - + + + pmid:30640040 + + p(HGNC:MDM4) association a(PUBCHEM:42640) + - pmid:25995053 + pmid:30640040 - complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") + p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) - pmid:25995053 + pmid:30640040 - p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") + p(HGNC:TGFBR1) association a(PUBCHEM:4521392) - pmid:25125464 + pmid:30640040 - p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) + p(HGNC:TGFBR1) association a(PUBCHEM:447966) - pmid:24853415 + pmid:30640040 - p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) + p(HGNC:TGFBR1) association a(PUBCHEM:11655119) - pmid:24853415 + pmid:30640040 - p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) + p(FPLX:ROCK) association a(PUBCHEM:46209426) - pmid:22926167 + pmid:30640040 - p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT) + p(HGNC:TNC) association a(PUBCHEM:3033825) - pmid:28137862 + pmid:30640040 - p(MGI:Dcaf1) association p(MGI:Dyrk1a) + p(HGNC:SELE) association a(PUBCHEM:9839311) - pmid:28137862 + pmid:30640040 - p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + p(HGNC:ICAM1) association a(PUBCHEM:9839311) - pmid:28137862 + pmid:30640040 - p(MGI:Dcaf1) association p(MGI:Hap1) + p(HGNC:TGFBR2) association a(PUBCHEM:11655119) + + + + - pmid:28137862 + pmid:29191965 - p(MGI:Dyrk1a) association p(MGI:Dcaf1) + composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) + + + + + + + + - pmid:28137862 + pmid:29191965 - p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") + + + + - pmid:28137862 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) + composite(p(HGNC:MAPT), p(HGNC:SPTB)) regulates a(GO:"microtubule cytoskeleton") + + + + - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") + complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") + p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") + p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") + p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") + p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) + p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) + p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(HBP:Neurodegeneration) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") + p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) - pmid:29221819 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) + p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) - pmid:28540658 + pmid:29191965 - p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) + p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") - pmid:28540658 + pmid:29191965 - p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) + p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) - pmid:28540658 + pmid:29191965 - p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) + p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) - pmid:28775333 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") + p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) - pmid:28775333 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") + p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") - pmid:28775333 + pmid:29191965 - p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases bp(GO:locomotion) - pmid:28775333 + pmid:29191965 - p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") @@ -124886,211 +125035,230 @@

Statements

- pmid:28137862 + pmid:29191965 - complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) - pmid:28137862 + pmid:29191965 - p(MGI:Hap1) association p(MGI:Dcaf1) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") - pmid:28137862 + pmid:29191965 - p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") - pmid:28137862 + pmid:29191965 - p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) - pmid:29221819 + pmid:29191965 - a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") - pmid:29221819 + pmid:25374103 - a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + p(HBP:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") - pmid:29221819 + pmid:25374103 - a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:29221819 + pmid:25374103 - bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) + p(HBP:"4R tau", var("p.Lys280del")) negativeCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:29221819 + pmid:29191965 - act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) + p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) - pmid:28884684 + pmid:29191965 - a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) - pmid:28884684 + pmid:29191965 - a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) negativeCorrelation bp(GO:"cell aging") - pmid:28884684 + pmid:29191965 - a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin)) + p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) - pmid:28884684 + pmid:29191965 - a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") + p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") - pmid:28884684 + pmid:29191965 - act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") + bp(GO:"cell aging") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) + + - pmid:28250274 + pmid:29191965 - p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) + complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) + + - pmid:28632203 + pmid:29191965 - p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") + complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") + + + + - pmid:28167836 + pmid:29191965 - act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) + + + + - pmid:28167836 + pmid:29191965 - act(p(HGNC:DYRK1A)) regulates a(GO:axon) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) - pmid:28250274 + pmid:29191965 - a(CHEBI:harmine) decreases p(HGNC:DYRK1A) + p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") - pmid:28250274 + pmid:29191965 - a(CHEBI:harmine) increases p(HGNC:MME) + a(GO:"cell body") association p(HGNC:MAPT) - pmid:29077046 + pmid:29191965 - a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) + p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:28775333 + pmid:26631930 - p(MGI:Mef2d) increases r(MGI:Dyrk1a) + p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:28775333 + pmid:29191965 - p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) + p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + + + pmid:26631930 + + p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + + @@ -125099,63 +125267,63 @@

Statements

- pmid:28632203 + pmid:29191965 - composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") + composite(p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")), p(HGNC:CDK5)) decreases a(MESH:Neurons) - pmid:28167836 + pmid:29191965 - p(HBP:"NP_001387.2:p.Arg205del") decreases act(p(HGNC:DYRK1A)) + a(PUBCHEM:6475963) decreases a(HBP:"Tau aggregates") - pmid:28167836 + pmid:29191965 - p(HBP:"NP_001387.2:p.Arg205del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") + a(PUBCHEM:6475963) positiveCorrelation bp(GO:locomotion) - pmid:28167836 + pmid:29191965 - p(HBP:"NP_001387.2:p.Glu239del") decreases act(p(HGNC:DYRK1A)) + a(PUBCHEM:66766582) decreases path(HBP:Neurodegeneration) - pmid:28167836 + pmid:29191965 - p(HBP:"NP_001387.2:p.Glu239del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") + a(CHEBI:azaperone) increases bp(GO:locomotion) - pmid:28167836 + pmid:29191965 - path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Arg205del") + a(CHEBI:azaperone) decreases p(HGNC:MAPT) - pmid:28167836 + pmid:29191965 - path(MESH:"Autism Spectrum Disorder") positiveCorrelation p(HBP:"NP_001387.2:p.Glu239del") + a(CHEBI:azaperone) decreases path(HBP:Neurodegeneration) @@ -125166,492 +125334,498 @@

Statements

- pmid:28877763 + pmid:29191965 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 301)) + composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(MESH:Longevity) - - - pmid:28877763 + pmid:29191965 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases bp(GO:locomotion) - pmid:25331948 + pmid:29191965 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + composite(a(CHEBI:ethosuximide), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) positiveCorrelation bp(GO:"insulin receptor signaling pathway") - pmid:28877763 + pmid:29191965 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:WNT2) association path(MESH:Tauopathies) - pmid:25331948 + pmid:29191965 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:TTBK2) association path(MESH:Tauopathies) - pmid:28877763 + pmid:17620722 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) - pmid:25331948 + pmid:17620722 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210)) - - - pmid:28877763 - - p(MGI:Syk) positiveCorrelation p(MGI:Mapt) - + + + - pmid:25331948 + pmid:25673844 - p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily") - pmid:25331948 + pmid:25673844 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) - pmid:28877763 + pmid:25673844 - p(MGI:Mapt, pmod(Ph, Ser, 301)) positiveCorrelation p(MGI:Syk) + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) - pmid:28877763 + pmid:25673844 - p(MGI:Syk, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) - pmid:28877763 + pmid:25673844 - p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) - pmid:28877763 + pmid:25673844 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) - pmid:28877763 + pmid:25673844 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) - pmid:18070606 + pmid:25473830 - p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18)) + p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) - pmid:26501932 + pmid:25473830 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") + p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) - pmid:26501932 + pmid:27607061 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies") + p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2)) - pmid:26501932 + pmid:26323690 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) + p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph)) - pmid:26501932 + pmid:26323690 - a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") + p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) - pmid:25331948 + pmid:26323690 - a(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) - pmid:25331948 + pmid:26323690 - a(HBP:"BAY61-3606") directlyDecreases act(p(HGNC:SYK)) + p(HGNC:TTBK2) association p(HGNC:CEP164) - pmid:28176663 + pmid:26323690 - a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164) - pmid:28176663 + pmid:26323690 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:TTBK2) association p(HGNC:MAPRE1) - pmid:28176663 + pmid:26323690 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110) - pmid:28176663 + pmid:26323690 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) - pmid:25987199 + pmid:26323690 - act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) - pmid:25987199 + pmid:29191965 - act(a(HBP:"advanced glycation end product")) negativeCorrelation act(p(MGI:Glp1r)) + p(HGNC:TAOK1) association path(MESH:Tauopathies) - - - pmid:26118667 + pmid:25974414 - complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) + act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) - - - pmid:26118667 + pmid:29191965 - p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) + p(HGNC:CTSE) association path(MESH:Tauopathies) - pmid:26118667 + pmid:29191965 - p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) + p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) - - - pmid:26118667 - - p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") - + + + + + - pmid:26118667 + pmid:29191965 - p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) + + + + - pmid:27087442 + pmid:29191965 - p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8") + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) decreases bp(GO:locomotion) - pmid:14642273 + pmid:29191965 - p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin)) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases path(HBP:Neurodegeneration) - pmid:14642273 + pmid:29191965 - p(HBP:"CDK5R1 p25") increases p(HBP:"Tau aggregates") + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) increases p(HGNC:MAPT) - pmid:26118667 + pmid:29191965 - p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25") + p(HGNC:ZC3H14) increases path(MESH:Tauopathies) - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205)) + bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(HBP:misfolding)) - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231)) + p(HGNC:DDC) increases a(CHEBI:dopamine) - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422)) + p(HGNC:DDC) increases a(CHEBI:serotonin) + + + + - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25") + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) - pmid:26118667 + pmid:29191965 - a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(HBP:Neurodegeneration) + + + + - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:GCH1) regulates a(CHEBI:dopamine) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNC:GCH1) regulates a(CHEBI:serotonin) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) + p(HGNC:GCH1) regulates act(p(HGNC:DDC)) + + + + - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1) + p(HGNC:TPH1) regulates a(CHEBI:dopamine) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:TPH1) regulates a(CHEBI:serotonin) - pmid:26118667 + pmid:29191965 - m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1) + p(HGNC:TPH1) regulates act(p(HGNC:DDC)) @@ -125662,256 +125836,261 @@

Statements

- pmid:26118667 + pmid:29191965 - complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1) + composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) - + + + pmid:29686391 + + a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + - pmid:26118667 + pmid:29686391 - complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") + tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils") - pmid:26118667 + pmid:29686391 - p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195") + g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") - pmid:26118667 + pmid:29686391 - p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195") + g(HGNC:TP53) decreases bp(GO:"cell proliferation") - pmid:26118667 + pmid:29686391 - p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1)) + bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) - pmid:26118667 + pmid:29686391 - act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain") + bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:26118667 + pmid:29686391 - p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195") + p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:27087442 + pmid:29686391 - path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5) + a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25987199 + pmid:29686391 - act(p(MGI:Glp1r)) increases act(p(MGI:Ppargc1a)) + a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) - pmid:25987199 + pmid:29686391 - act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin)) + a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) - pmid:25987199 + pmid:29686391 - act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") - pmid:25987199 + pmid:29686391 - act(p(MGI:Glp1r)) negativeCorrelation act(a(HBP:"advanced glycation end product")) + p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25143394 + pmid:29686391 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) + p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25143394 + pmid:29686391 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) + p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25143394 + pmid:29686391 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) + bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) - pmid:23134599 + pmid:29686391 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(RGD:Ppp2ca) + bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) - pmid:25125464 + pmid:29686391 - p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8") + p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") - pmid:25125464 + pmid:29686391 - p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1") + p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25125464 + pmid:29686391 - p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8) + p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25125464 + pmid:29686391 - p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates") + p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25125464 + pmid:29686391 - p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh) + p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin") - pmid:25125464 + pmid:29686391 - p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1) + p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:25125464 + pmid:29686391 - a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) + p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:19459590 + pmid:29686391 - p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:19459590 + pmid:29686391 - p(HBP:"Tau epitope, CP13") decreases act(p(HGNC:MAPT)) + a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) - pmid:23294633 + pmid:29686391 - a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22833681 + pmid:29686391 - p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf a(HBP:"Tau epitope, AT100") + a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22833681 + pmid:29686391 - p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf a(HBP:"Tau epitope, AT100") + a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) @@ -125920,174 +126099,163 @@

Statements

- - - pmid:22833681 - - a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169")) - + - pmid:22833681 + pmid:29686391 - act(p(ECCODE:"3.2.1.169")) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + - pmid:23294633 + pmid:29686391 - p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") + + - pmid:23294633 + pmid:29686391 - p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin)) + a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:23294633 + pmid:29686391 - p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:23294633 + pmid:29686391 - p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin)) + a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22002427 + pmid:29686391 - p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22002427 + pmid:29686391 - p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation a(GO:"neurofibrillary tangle") + p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:24033439 + pmid:29686391 - p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:24033439 + pmid:29686391 - p(HBP:"Tau epitope, PHF1") increases a(GO:"neurofibrillary tangle") + p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin") - pmid:24251416 + pmid:29686391 - p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4") + p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22156579 + pmid:29686391 - act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) + p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:22156579 + pmid:29686391 - p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) + p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin") - pmid:22941973 + pmid:28877763 - act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + p(HGNC:MAPT, pmod(HBP:misfolded)) positiveCorrelation act(p(HGNC:SYK)) - - - pmid:22941973 - - act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization") - + - pmid:22941973 + pmid:25374103 - act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp)) + composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") - pmid:22941973 + pmid:25374103 - act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel) + p(MGI:Stub1) decreases act(p(MGI:Casp3)) - pmid:23722080 + pmid:25374103 - a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) + p(MGI:Stub1) decreases p(HBP:"Tau C3") - - - pmid:23722080 - - a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) - + @@ -126095,9 +126263,9 @@

Statements

- pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau isoform F (441 aa)") @@ -126106,931 +126274,862 @@

Statements

- pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 404)) + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) + composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") - - - pmid:23722080 - - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25") - - - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") + composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") - - - - - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) + composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) - pmid:23722080 + pmid:25374103 - composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") + composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:22952452 + pmid:25374103 - p(HGNC:TRAK1) positiveCorrelation act(a(GO:mitochondrion)) + composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") + + - pmid:22952452 + pmid:25374103 - p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) - pmid:22952452 + pmid:25374103 - p(HGNC:TRAK1) negativeCorrelation p(HGNC:MARK1) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) + + - pmid:22952452 + pmid:25374103 - p(HGNC:RHOT1) positiveCorrelation act(a(GO:mitochondrion)) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:22952452 + pmid:25374103 - p(HGNC:RHOT1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") - pmid:22952452 + pmid:25374103 - p(HGNC:RHOT1) negativeCorrelation p(HGNC:MARK1) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:23001711 + pmid:25374103 - p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) positiveCorrelation bp(GO:"mitochondrion transport along microtubule") - pmid:22072628 + pmid:25374103 - p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") + a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) - - - pmid:22072628 - - p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") - + - - - pmid:8226987 - - p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT)) - + - pmid:24401760 + pmid:25374103 - p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") + complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) - - - pmid:24401760 - - p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite") - + + + - pmid:24401760 + pmid:25374103 - p(MGI:Itpkb) increases bp(GO:"apoptotic process") + p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) - - - pmid:24401760 - - p(MGI:Itpkb) increases p(MGI:Bace1) - + - - - pmid:24401760 - - p(MGI:Itpkb) increases act(p(MGI:Bace1)) - + - - - pmid:24401760 - - p(MGI:Itpkb) increases act(p(MGI:Map2k1)) - + - - - pmid:24401760 - - p(MGI:Itpkb) increases act(p(MGI:Map2k2)) - + - pmid:24401760 + pmid:25374103 - p(MGI:Itpkb) increases a(HBP:Astrogliosis) + complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"Tau isoform F (441 aa)") - pmid:24401760 + pmid:25374103 - p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) + complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"4R tau", var("p.Lys280del")) - - - pmid:24401760 - - p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - + - pmid:24401760 + pmid:25374103 - a(HBP:"SL-327") directlyDecreases p(MGI:Map2k1) + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)") - pmid:24401760 + pmid:25374103 - a(HBP:"SL-327") directlyDecreases p(MGI:Map2k2) + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau isoform F (441 aa)") - pmid:24401760 + pmid:25374103 - a(HBP:"SL-327") decreases a(CHEBI:"amyloid-beta") + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3") - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5)) + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"Tau C3") - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1") + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del")) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25")) + bp(GO:"mitochondrion transport along microtubule") negativeCorrelation p(HBP:"4R tau", var("p.Lys280del")) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b)) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193594") isA a(HBP:diaminothiazole) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193665") isA a(HBP:diaminothiazole) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5)) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b)) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) - pmid:23737518 + pmid:25374103 - a(HBP:"LDN-213843") isA a(HBP:diaminothiazole) + bp(GO:"mitochondrion transport along microtubule") positiveCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) - pmid:23737518 + pmid:28420982 - a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5)) + a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") - pmid:23737518 + pmid:28420982 - a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b)) + bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) - - - pmid:7667312 - - p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments") - + - pmid:7667312 + pmid:28420982 - a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments") + a(MESH:Exosomes) association sec(p(HGNC:MAPT)) - pmid:25672970 + pmid:29238289 - a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B)) + act(a(MESH:Exosomes)) association p(HGNC:MAPT) - pmid:25672970 + pmid:28420982 - a(HBP:"C-30-27") increases path(MESH:Cognition) + a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") - pmid:25672970 + pmid:28420982 - act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) + a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:25546293 + pmid:28420982 - p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + a(GO:microvesicle) association sec(p(HGNC:MAPT)) - pmid:24686445 + pmid:28420982 - act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK)) + a(GO:microvesicle) regulates sec(p(HGNC:MAPT)) - - - pmid:24686445 - - act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) - + - pmid:25672970 + pmid:28420982 - p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B)) + complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT)) + + - pmid:24844691 + pmid:28420982 - a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6)) + complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) - - - pmid:24844691 - - a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta") - + - pmid:24844691 + pmid:28420982 - a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + + - pmid:24844691 + pmid:28420982 - a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6)) + complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) - pmid:24844691 + pmid:28420982 - a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta") + complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates") + + - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1)) + complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1)) + complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1)) + a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub)) + a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques") - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane)) + a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") - pmid:25546293 + pmid:28420982 - p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) negativeCorrelation act(p(HGNC:HDAC6)) + a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils") - pmid:25546293 + pmid:28420982 - a(CHEBI:vorinostat) directlyDecreases act(p(HGNC:HDAC6)) + a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils") - pmid:25546293 + pmid:28420982 - a(CHEBI:vorinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) - pmid:25546293 + pmid:28420982 - a(HBP:crebinostat) directlyDecreases act(p(HGNC:HDAC6)) + a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) - pmid:25546293 + pmid:28420982 - a(HBP:crebinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") + + + + - pmid:27917100 + pmid:28420982 - a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) + a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies) + + + + - pmid:26890116 + pmid:28420982 - a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) + complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) - pmid:18558669 + pmid:28420982 - a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) + p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") - pmid:29540553 + pmid:26631930 - p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174)) + p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates") - pmid:29540553 + pmid:26631930 - p(MGI:Sirt1) positiveCorrelation a(GO:"neuron to neuron synapse") + p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") - pmid:29540553 + pmid:28420982 - p(MGI:Sirt1) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") + + + + - pmid:29540553 + pmid:28420982 - a(GO:"neuron to neuron synapse") positiveCorrelation p(MGI:Sirt1) + complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) - pmid:29540553 + pmid:23702978 - p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713")) + complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") - pmid:29540553 + pmid:29311797 - p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT) + path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) - pmid:29540553 + pmid:29276758 - p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) + path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) - pmid:29540553 + pmid:29311797 - p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HSP90AA1) association bp(GO:growth) - pmid:27550730 + pmid:29311797 - a(HBP:"CM-414") directlyDecreases act(p(MGI:Pde5a)) + p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") - pmid:27550730 + pmid:29311797 - a(HBP:"CM-414") directlyDecreases act(p(ECCODE:"3.5.1.98")) + p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) - pmid:27550730 + pmid:29311797 - a(HBP:"CM-414") decreases a(CHEBI:"amyloid-beta") + p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") - pmid:27550730 + pmid:29311797 - a(HBP:"CM-414") decreases p(MGI:Mapt, pmod(Ph)) + bp(GO:growth) association p(HGNC:HSP90AA1) - pmid:27550730 + pmid:29311797 - a(HBP:"CM-414") decreases act(p(MGI:Gsk3b), ma(kin)) + bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) - pmid:27550730 + pmid:29311797 - act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) + bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) - pmid:29559585 + pmid:29311797 - p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300)) + path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) - pmid:29559585 + pmid:29311797 - p(MGI:Gapdh, pmod(NO)) positiveCorrelation p(MGI:Mapt, pmod(Ac, Lys, 280)) + bp(GO:"embryo development") association p(HGNC:HSP90AB1) - - - pmid:29559585 + pmid:29311797 - act(p(MGI:Ep300)) positiveCorrelation p(MGI:Sirt1, pmod(NO)) + bp(GO:"cell maturation") association p(HGNC:HSP90AB1) - pmid:29559585 + pmid:29311797 - p(MGI:Sirt1, pmod(NO)) positiveCorrelation act(p(MGI:Ep300)) + bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) - pmid:29559585 + pmid:29311797 - p(MGI:Sirt1, pmod(NO)) increases act(p(MGI:Sirt1)) + p(HGNC:PPID) isA a(MESH:Immunophilins) - pmid:29559585 + pmid:29311797 - p(MGI:Mapt, pmod(Ac, Lys, 280)) positiveCorrelation p(MGI:Gapdh, pmod(NO)) + p(HGNC:PPID) decreases a(HBP:"Tau fibrils") - pmid:29559585 + pmid:29311797 - a(HBP:CGP3466B) decreases p(MGI:Gapdh, pmod(NO)) + p(HGNC:PPID) decreases a(HBP:"Tau aggregates") - - - pmid:28855586 + pmid:29311797 - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 163)) + p(HGNC:PPID) increases bp(GO:memory) - - - pmid:28855586 + pmid:29311797 - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") - - - pmid:28855586 + pmid:29311797 - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 281)) + p(HGNC:FKBPL) isA a(MESH:Immunophilins) - - - pmid:28855586 - - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 369)) - + - - - pmid:28855586 - - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases p(HGNC:MAPT, pmod(Ph)) - + - - - pmid:28855586 - - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases act(p(HGNC:MAPT)) - + - - - pmid:28855586 - - composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) negativeCorrelation act(a(CHEBI:"amyloid-beta")) - + - - - pmid:28287136 - - p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates") - + + + + + + + - pmid:28002468 + pmid:29311797 - p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif") + complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") @@ -127041,1549 +127140,1519 @@

Statements

- pmid:28002468 + pmid:29311797 - p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif") + bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates") - pmid:28002468 + pmid:29311797 - p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif") + p(HGNC:TOMM34) decreases path(MESH:Tauopathies) - - - pmid:28002468 - - a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac)) - + - pmid:28002468 + pmid:29311797 - a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) + complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) - pmid:27041503 + pmid:29311797 - p(HGNC:WWC1) negativeCorrelation bp(MESH:"Long-Term Potentiation") + complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) - pmid:26390242 + pmid:21367866 - a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) + complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(kin)) - pmid:26390242 + pmid:29311797 - a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:26390242 + pmid:11943212 - a(CHEBI:salsalate) decreases p(HGNC:MAPT) + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) - pmid:26390242 + pmid:11943212 - a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus) + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) - pmid:26192747 + pmid:11943212 - p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - pmid:26192747 + pmid:11943212 - p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - - - pmid:26192747 - - p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") - + - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:S100A1) increases p(HGNC:MAPT) - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region") + p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph)) + + - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac)) + complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + + - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region") + complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) + + + + + + + + - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac)) + p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region") + p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) - pmid:26192747 + pmid:29311797 - p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac)) + p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90)) - pmid:24686445 + pmid:29311797 - a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF) + p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) - pmid:24686445 + pmid:29311797 - p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43) + a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) - pmid:24686445 + pmid:29311797 - p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL) + a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) - pmid:24686445 + pmid:29311797 - p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF) + a(PUBCHEM:14719853) decreases p(HGNC:MAPT) - - - - - pmid:23487739 + pmid:29311797 - a(HBP:Tubacin) directlyDecreases act(p(HGNC:HDAC6)) + a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) - pmid:21427723 + pmid:29311797 - a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) + a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) - pmid:21427723 + pmid:29311797 - a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) + a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) - pmid:20869593 + pmid:29311797 - a(HBP:C646) directlyDecreases act(p(HGNC:EP300)) + a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") - pmid:20869593 + pmid:29311797 - a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac)) + a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:29540553 + pmid:26751493 - a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:29226865 + pmid:26631930 - p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) + p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:28771976 + pmid:26631930 - a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") - pmid:28771976 + pmid:26631930 - a(HBP:RGFP966) association bp(GO:memory) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") - pmid:29844403 + pmid:26631930 - a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory) - pmid:29844403 + pmid:29121589 - a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Astrogliosis) - pmid:29844403 + pmid:29121589 - a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:Microgliosis) - pmid:29844403 + pmid:29121589 - a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) - pmid:29844403 + pmid:29121589 - a(HBP:MPT0G211) increases bp(GO:learning) + p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) - pmid:29844403 + pmid:23294633 - a(HBP:MPT0G211) increases bp(GO:memory) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) - pmid:19732809 + pmid:23294633 - a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) - pmid:19732809 + pmid:23294633 - a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:19732809 + pmid:23294633 - a(HBP:"O-GlcNAcylation") association bp(MESH:"Hot Temperature") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:19732809 + pmid:23294633 - a(HBP:"O-GlcNAcylation") negativeCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:"Tau epitope, AT100") - pmid:19732809 + pmid:23294633 - g(HGNC:OGT) positiveCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:26041011 + pmid:11606569 - a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif") - pmid:27325702 + pmid:11606569 - p(HBP:"APP, ACR") association p(HGNC:STUB1) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif") - pmid:27325702 + pmid:27716675 - p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation a(HBP:neuroinflammation) - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) + r(MGI:Mapt) partOf a(CL:0000127) - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) + r(MGI:Mapt) partOf a(CL:0000128) - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:28176663 - p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") + p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") - pmid:27325702 + pmid:8226987 - p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") + p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT)) - pmid:27325702 + pmid:26751493 - p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) + p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27325702 + pmid:26751493 - p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") + p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - - - - pmid:27325702 + pmid:26751493 - complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex") + p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - - - - - - - - - - pmid:25378699 + pmid:26751493 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25378699 + pmid:26751493 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:16464864 + pmid:26631930 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24905733 + pmid:26631930 - p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub)) + p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments") - pmid:8391280 + pmid:26751493 - p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") + p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:8391280 + pmid:26751493 - p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") + p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260838 + pmid:26751493 - p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") + p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260838 + pmid:26751493 - p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain") + p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27260838 + pmid:26751493 - p(HBP:pretangles) positiveCorrelation p(HBP:"phosphatase-activating domain") + p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27601475 + pmid:26751493 - a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers") + p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) - pmid:27601475 + pmid:26751493 - a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide") + p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) - pmid:27601475 + pmid:10464280 - act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide") + p(HBP:"microtubule-binding region") isA p(HGNC:MAPT) - pmid:27373205 + pmid:10464280 - p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HBP:"microtubule-binding region") association act(complex(GO:"protein phosphatase type 2A complex")) - pmid:11606569 + pmid:10464280 - g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) + p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) - pmid:27716675 + pmid:18500754 - a(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HBP:"microtubule-binding region") association p(HGNC:HSPA8) - pmid:27716675 + pmid:18500754 - a(HBP:neuroinflammation) positiveCorrelation g(DBSNP:rs63751438) + p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") - pmid:27716675 + pmid:8391280 - a(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers") + p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) - pmid:27716675 + pmid:26751493 - g(DBSNP:rs63751438) positiveCorrelation a(HBP:neuroinflammation) + p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") - pmid:19765634 + pmid:26751493 - g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") - pmid:19765634 + pmid:17493042 - g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") - pmid:19765634 + pmid:26751493 - g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") - pmid:21843595 + pmid:17493042 - p(MGI:Sumo3) negativeCorrelation bp(GO:learning) + p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274")) - pmid:21843595 + pmid:23407988 - p(MGI:Sumo3) negativeCorrelation bp(GO:memory) + p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau") - pmid:19782030 + pmid:23407988 - act(p(RGD:Stat1)) increases r(RGD:Irf1) + p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") - pmid:19782030 + pmid:26751493 - act(p(RGD:Stat1)) increases r(RGD:Tnf) + p(HBP:"tubulin-binding repeat 1") association p(HBP:"APOE e3") - pmid:19782030 + pmid:26751493 - act(p(RGD:Stat1)) increases r(RGD:Il6) + g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") - pmid:19782030 + pmid:26751493 - p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo)) + p(HBP:"projection domain") association p(HGNC:LCK) - pmid:19782030 + pmid:26751493 - p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1)) + p(HBP:"projection domain") association p(HGNC:FGR) - - - pmid:19782030 + pmid:26751493 - p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo)) + p(HBP:"projection domain") association p(HGNC:SRC) - pmid:19782030 + pmid:26751493 - p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1)) + p(HBP:"projection domain") association p(HGNC:GRB2) - - - - - - - pmid:19323834 + pmid:26751493 - complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) + p(HBP:"projection domain") association p(FPLX:PLC) - pmid:19323834 + pmid:26751493 - p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) - pmid:19323834 + pmid:26751493 - p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) + p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") - pmid:18675254 + pmid:26751493 - p(HGNC:UBE2I) partOf complex(GO:"endoplasmic reticulum") + p(HBP:"projection domain") association p(HGNC:PIN1) - pmid:19323834 + pmid:26751493 - p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) + p(HBP:"projection domain") partOf p(HGNC:MAPT) - pmid:18675254 + pmid:26751493 - p(HGNC:APP, pmod(Sumo, Lys, 587)) decreases a(CHEBI:"amyloid-beta") + p(HBP:"projection domain") association p(HGNC:FYN) - pmid:18675254 + pmid:26751493 - p(HGNC:APP, pmod(Sumo, Lys, 595)) decreases a(CHEBI:"amyloid-beta") + p(HBP:"projection domain") association p(HGNC:DLG4) - pmid:18675254 + pmid:26751493 - p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) + p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") - pmid:18675254 + pmid:26751493 - p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) + p(HGNC:FGR) association p(HBP:"projection domain") - pmid:17346237 + pmid:26751493 - p(HGNC:SUMO3) increases p(HGNC:BACE1) + p(HGNC:FGR) association a(HBP:"projection domain") - pmid:17346237 + pmid:26751493 - p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_711")) + p(HGNC:GRB2) association p(HBP:"projection domain") + + - pmid:17346237 + pmid:26751493 - p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_713")) + p(HGNC:GRB2) association a(HBP:"projection domain") - pmid:16464864 + pmid:26751493 - a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") - pmid:12506199 + pmid:26751493 - p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta") + a(CHEBI:"phosphatidylinositol bisphosphate") association a(HBP:"projection domain") - pmid:12506199 + pmid:26751493 - p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") + path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") - pmid:29334120 + pmid:26631930 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") - pmid:29334120 + pmid:22057784 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) - pmid:29334120 + pmid:17050703 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) - pmid:29334120 + pmid:21427723 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) - pmid:29334120 + pmid:21427723 - p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) + path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy") - pmid:29334120 + pmid:26751493 - p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) + path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") - pmid:26142647 + pmid:26751493 - p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) + p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:29421605 + pmid:26631930 - p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph)) + p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:29421605 + pmid:26631930 - p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph)) + p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates") - pmid:29421605 + pmid:26751493 - p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) + p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:29421605 + pmid:26631930 - p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph)) + p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:29421605 + pmid:26631930 - p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) + p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates") - pmid:29421605 + pmid:26631930 - p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + p(HGNC:MAPT, var("p.Gly272Val")) decreases p(HBP:"4R tau") - - - pmid:29421605 + pmid:26631930 - p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau") - - - pmid:29421605 + pmid:26751493 - p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:29421605 + pmid:26631930 - p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - - - pmid:29421605 + pmid:26631930 - p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates") - - - pmid:29062069 + pmid:26751493 - p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) + p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:28720530 + pmid:26751493 - p(HGNC:PPP2R5E) partOf complex(GO:"protein phosphatase type 2A complex") + p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") - pmid:28422052 + pmid:26751493 - a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") - pmid:28422052 + pmid:26751493 - a(CHEBI:"folic acid") increases p(MGI:Dnmt1) + g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") - pmid:28422052 + pmid:26751493 - p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309)) + g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") - pmid:28422052 + pmid:26751493 - p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca)) + p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") - pmid:25143394 + pmid:25974414 - p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") - pmid:25143394 + pmid:22002427 - p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") - pmid:23134599 + pmid:25974414 - a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23134599 + pmid:25974414 - a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) + p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) - pmid:23134599 + pmid:22002427 - a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:23134599 + pmid:22002427 - p(RGD:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) - pmid:21489990 + pmid:26751493 - act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) - pmid:21489990 + pmid:26751493 - p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5)) + p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") - pmid:19623258 + pmid:26751493 - act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT8") + p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") + + - pmid:19623258 + pmid:26751493 - act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT180") + p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") + + + + - pmid:19623258 + pmid:26751493 - p(HBP:"Tau epitope, AT180") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) + complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) - pmid:19623258 + pmid:26751493 - p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:25001178 + pmid:26751493 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1)) + a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:25001178 + pmid:26751493 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin)) + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(ECCODE:"3.1.1.89")) - pmid:25001178 + pmid:26751493 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin)) + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") positiveCorrelation act(complex(GO:"respiratory chain complex I")) - pmid:25001178 + pmid:29281045 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) + p(ECCODE:"3.1.1.89") decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) - pmid:25001178 + pmid:26751493 - m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:PPP1CA)) + act(complex(GO:"respiratory chain complex I")) positiveCorrelation a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") - pmid:25001178 + pmid:26751493 - m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:DUSP6)) + p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - pmid:25001178 + pmid:28019679 - m(MIRBASE:"hsa-mir-125b-1") directlyDecreases act(p(HGNC:BCL2L2)) + p(HGNC:CASP1) increases act(p(HGNC:IL18)) - pmid:25001178 + pmid:23702978 - act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:24964035 + pmid:23702978 - p(HGNC:SMAD2) decreases p(HGNC:PIN1) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - - - - - pmid:24964035 + pmid:23702978 - p(HGNC:SMAD3) decreases p(HGNC:PIN1) + act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18)) - pmid:23832849 + pmid:24561250 - act(p(INTERPRO:"FKBP-type peptidyl-prolyl cis-trans isomerase domain")) directlyDecreases p(HBP:"tubulin-binding repeat 3") + p(HGNC:CASP1) increases p(HGNC:IL18) - pmid:22926167 + pmid:24561250 - p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT) + p(HGNC:CASP1) increases p(HGNC:IL18) - pmid:22926167 + pmid:27314526 - p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases act(p(HGNC:PIN1)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:22926167 + pmid:27314526 - p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT) + sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:22926167 + pmid:27314526 - p(HGNC:PIN1, pmod(Ph, Ser, 65)) increases act(p(HGNC:PIN1)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:22926167 + pmid:27314526 - p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:19401603 + pmid:28019679 - complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CASP1) increases act(p(HGNC:IL1B)) - pmid:28019679 + pmid:23702978 - bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:28019679 + pmid:23702978 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:28019679 + pmid:23702978 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B)) - pmid:28019679 + pmid:23702978 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) @@ -128592,45 +128661,43 @@

Statements

pmid:24561250 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + p(HGNC:CASP1) increases p(HGNC:IL1B) - pmid:24561250 + pmid:27314526 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:28019679 + pmid:27314526 - complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) + sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:28019679 + pmid:27314526 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - - pmid:27314526 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) @@ -128639,7 +128706,7 @@

Statements

pmid:28019679 - complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") + act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") @@ -128648,7 +128715,7 @@

Statements

pmid:28019679 - complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) + act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF)) @@ -128657,275 +128724,261 @@

Statements

pmid:28019679 - act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") + act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) - pmid:28019679 + pmid:23702978 - act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") + act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) - - pmid:24561250 - complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") + p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24561250 + pmid:27314526 - complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") + act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) - pmid:28019679 + pmid:27314526 - a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) - pmid:24561250 + pmid:26751493 - p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") + p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") - pmid:24561250 + pmid:27041503 - p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1) - pmid:27314526 + pmid:27041503 - p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"actin filament polymerization") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) association path(MESH:"Alzheimer Disease") + a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") - pmid:24561250 + pmid:26751493 - p(HGNC:IL18) increases bp(GO:"inflammatory response") + a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) + a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) increases bp(GO:"microglial cell activation") + a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) increases bp(GO:"astrocyte activation") + a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") + a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) increases p(HGNC:GSK3B) + a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") - pmid:27314526 + pmid:26751493 - p(HGNC:IL18) increases p(HGNC:CDK5) + a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") - - - - - pmid:28019679 + pmid:26751493 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) + a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") - - - - - pmid:28019679 + pmid:26751493 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") - pmid:28019679 + pmid:26751493 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") - pmid:23702978 + pmid:26751493 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") - - - pmid:28019679 + pmid:26751493 - act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) + a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") - pmid:28019679 + pmid:26751493 - act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") - pmid:28019679 + pmid:26458742 - complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Thr, 205)) - pmid:28019679 + pmid:26458742 - complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 262)) - pmid:23702978 + pmid:26458742 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 400)) - - - pmid:24561250 + pmid:26458742 - complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 404)) - pmid:24561250 + pmid:26458742 - act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 409)) - pmid:24561250 + pmid:26458742 - act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) + p(HBP:HBP00056, var("p.Pro301Leu")) increases p(HBP:HBP00056, pmod(Ph, Ser, 422)) - pmid:24561250 + pmid:26458742 - act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) + p(HBP:HBP00056, var("p.Pro301Leu")) increases a(HBP:HBP00006) @@ -128936,511 +128989,613 @@

Statements

+ + + + + + + + - pmid:28019679 + pmid:26195256 - a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) + bp(GO:"import into cell") decreases a(HBP:"amyloid-beta derived diffusible ligands") - pmid:28019679 + pmid:26195256 - a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") + a(MESH:"Extracellular Fluid") decreases p(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) - pmid:23702978 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + p(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) + path(MESH:"Craniocerebral Trauma") association path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") increases p(HGNC:IL1B) + path(MESH:"Sleep Initiation and Maintenance Disorders") association path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) + path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + a(MESH:"Cerebral Ventricles") association path(MESH:"Alzheimer Disease") - pmid:23702978 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + p(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation p(HGNC:APP, loc(GO:"extracellular region")) - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) + act(p(MESH:Ubiquitin)) decreases p(HGNC:APP) - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") increases p(HGNC:IL18) + act(p(MESH:Ubiquitin)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:24561250 + pmid:26195256 - act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) + p(MESH:Ubiquitin) decreases p(HGNC:MAPT) + + + + - pmid:24561250 + pmid:26195256 - complex(GO:"inflammasome complex") regulates p(HGNC:IL18) + act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) decreases p(HGNC:APP) - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + act(p(MESH:"Amyloid Precursor Protein Secretases")) increases a(CHEBI:"amyloid-beta") - - - - - pmid:23702978 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + act(p(MESH:Cathepsins)) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:24561250 + pmid:26195256 - act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + p(MESH:Neprilysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:27314526 + pmid:26195256 - act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + p(MESH:"Matrix Metalloproteinase 9") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + p(MESH:"Matrix Metalloproteinase 2") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:23702978 + pmid:26195256 - act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) + p(MESH:"Matrix Metalloproteinase 3") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:23702978 + pmid:26195256 - complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + p(MESH:"Glutamate Carboxypeptidase II") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + p(MESH:"Endothelin-Converting Enzymes") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) - + + + pmid:26195256 + + p(MESH:"Tissue Plasminogen Activator") decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + + + + pmid:26195256 + + p(MESH:Fibrinolysin) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + + + + + pmid:26195256 + + p(HGNC:ACE) decreases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + + + + + pmid:29626319 + + p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + + + + + pmid:29626319 + + p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + + + + + pmid:29626319 + + p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) + + + + + pmid:29626319 + + p(HGNC:ACE) regulates a(MESH:"Body Fluids") + + + + + pmid:29626319 + + p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") + + - pmid:23702978 + pmid:29626319 - complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) + p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") + + + pmid:29626319 + + act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) + a(MESH:"Muscle, Smooth, Vascular") decreases a(CHEBI:"amyloid-beta") - pmid:27314526 + pmid:26195256 - complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") + a(MESH:Insulin) increases a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:26195256 - p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) + a(MESH:Insulin) association a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) - pmid:24561250 + pmid:29626319 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) - pmid:24561250 + pmid:29626319 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + p(HGNC:A2M) regulates a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) increases p(HGNC:IL18) + p(HGNC:LRP2) regulates a(CHEBI:"amyloid-beta") - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) increases p(HGNC:IL1B) + p(HGNC:PPIA) association act(a(MESH:"Blood-Brain Barrier")) - pmid:24561250 + pmid:26195256 - p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(HBP:"perivascular drainage pathways") association a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:26195256 - path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) + path(HBP:"high-fat prenatal maternal diet") increases a(CHEBI:"amyloid-beta") - pmid:23702978 + pmid:26195256 - path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") + path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) - pmid:23702978 + pmid:26195256 - path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") + path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow") + + + pmid:29626319 + + path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") + + - pmid:23702978 + pmid:26195256 - complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) + act(p(MESH:Lysosomes)) decreases p(HGNC:MAPT) - pmid:23702978 + pmid:26195256 - bp(GO:"cell activation") increases p(HGNC:IL18) + p(MESH:"Cyclic AMP-Dependent Protein Kinases") increases p(HGNC:MAPT, pmod(Ph)) - pmid:24561250 + pmid:26195256 - p(HGNC:NLRP1) increases p(HGNC:IL18) + act(p(MESH:Calpain)) decreases p(HGNC:MAPT) - pmid:24561250 + pmid:26195256 - p(HGNC:NLRP1) increases p(HGNC:IL1B) + p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic") + + + pmid:27373205 + + p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates") + + + + + pmid:27373205 + + p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers") + + - pmid:27314526 + pmid:27373205 - p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport") - pmid:27314526 + pmid:27373205 - act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) + p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport") + + + + - pmid:23702978 + pmid:27373205 - p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers") - pmid:23702978 + pmid:27373205 - p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers") - pmid:23702978 + pmid:27373205 - p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport") - pmid:23702978 + pmid:27373205 - act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport") + + - pmid:24561250 + pmid:27373205 - p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") - pmid:23702978 + pmid:27373205 - complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers") - pmid:24561250 + pmid:27373205 - complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) decreases bp(GO:"anterograde axonal protein transport") - pmid:24561250 + pmid:27373205 - complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) + composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + - pmid:24561250 + pmid:26631930 - act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) + g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24561250 + pmid:26631930 - complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + g(HGNC:MIR132) decreases p(HBP:"4R tau") - pmid:24561250 + pmid:26631930 - complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") + g(HGNC:MIR219A1) increases complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) @@ -129451,107 +129606,123 @@

Statements

- pmid:23702978 + pmid:26631930 - composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) decreases p(HGNC:MAPT) - + + + pmid:26631930 + + p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") + - pmid:23702978 + pmid:26631930 - composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) - pmid:23702978 + pmid:26631930 - act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) + p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") - pmid:23702978 + pmid:26631930 - act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) + a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) - pmid:23702978 + pmid:26631930 - a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) + complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2) - pmid:27314526 + pmid:26631930 - a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:SRSF2) increases p(HBP:"4R tau") - pmid:23702978 + pmid:29226865 - act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") + act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") - pmid:23702978 + pmid:26631930 - a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) + p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + - pmid:23702978 + pmid:29226865 - act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") + act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) + + + + - pmid:23702978 + pmid:26631930 - a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) + complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") - + + + pmid:26631930 + + complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(HBP:Neurodegeneration) + - pmid:23702978 + pmid:24561250 - complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) + a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) @@ -129562,9 +129733,9 @@

Statements

- pmid:23702978 + pmid:26631930 - complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) + complex(a(GO:microtubule), p(HBP:"4R tau")) increases bp(GO:"microtubule polymerization") @@ -129575,1123 +129746,1241 @@

Statements

- pmid:23702978 + pmid:26631930 - act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") + complex(a(GO:microtubule), p(HBP:"3R tau")) increases bp(GO:"microtubule polymerization") - pmid:24561250 + pmid:26631930 - p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) + p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - pmid:23702978 + pmid:26631930 - p(HGNC:SCAF11) increases bp(GO:pyroptosis) + p(HGNC:MAPT, pmod(Ph, Ser, 214), pmod(Ph, Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:23702978 + pmid:26631930 - act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) + p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) - pmid:23702978 + pmid:26631930 - a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + + + + + + + + - pmid:23702978 + pmid:26631930 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I")) + complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") - pmid:23702978 + pmid:26631930 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) + complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") - pmid:23702978 + pmid:26631930 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) + complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases bp(GO:"axonal transport") - pmid:23702978 + pmid:26631930 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) + complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") - pmid:23702978 + pmid:19491104 - a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B)) + act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) - pmid:23702978 + pmid:19491104 - a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18)) + act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) - pmid:23702978 + pmid:19491104 - act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) + act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") - pmid:23702978 + pmid:26631930 - p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) + p(HGNC:EP300) increases p(HGNC:MAPT, pmod(Ac, Lys)) - + + + pmid:11691934 + + p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac)) + - pmid:23702978 + pmid:20869593 - act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163)) - pmid:23702978 + pmid:20869593 - p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174)) - pmid:23702978 + pmid:20869593 - p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180)) - pmid:23702978 + pmid:20869593 - p(HGNC:IL1A) increases bp(GO:"inflammatory response") + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254)) - pmid:23702978 + pmid:20869593 - p(HGNC:CASP8) increases act(p(HGNC:IL1B)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274)) - pmid:23702978 + pmid:20869593 - act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280)) - pmid:23702978 + pmid:20869593 - act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281)) - pmid:23702978 + pmid:20869593 - act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290)) - pmid:23702978 + pmid:20869593 - act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298)) - + + + pmid:20869593 + + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) + - pmid:23702978 + pmid:20869593 - complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) - - - + + + pmid:20869593 + + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331)) + - pmid:23702978 + pmid:20869593 - complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352)) - pmid:23702978 + pmid:20869593 - complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369)) - + + + pmid:20869593 + + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370)) + + + + pmid:20869593 + + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383)) + + - pmid:23702978 + pmid:20869593 - complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385)) - pmid:23702978 + pmid:20869593 - p(HGNC:XIAP) decreases complex(GO:ripoptosome) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395)) - pmid:23702978 + pmid:26631930 - p(HGNC:BIRC3) decreases complex(GO:ripoptosome) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280))) - pmid:23702978 + pmid:26631930 - act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pmid:29276758 - act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pmid:21427723 - act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pmid:26631930 - p(FPLX:TNFRSF) increases p(HGNC:NLRP3) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") - pmid:23702978 + pmid:26631930 - p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub)) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:23702978 + pmid:26631930 - p(FPLX:IFNB) increases p(HGNC:AIM2) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:23702978 + pmid:29276758 - g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") + p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons) + + + pmid:29276758 + + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") + + - pmid:24561250 + pmid:28855586 - g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(Ac, Lys, 280)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) - pmid:24561250 + pmid:28287136 - g(HGNC:NLRP3) decreases bp(GO:memory) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:24561250 + pmid:28287136 - g(HGNC:NLRP3) decreases bp(GO:behavior) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:"Tau aggregates") - pmid:23702978 + pmid:28287136 - path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"VQIINK motif") - pmid:23702978 + pmid:26940749 - bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) - pmid:23702978 + pmid:26940749 - bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration) - pmid:23702978 + pmid:26192747 - act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") + p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac)) - pmid:27314526 + pmid:26192747 - act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") + p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf a(HBP:"microtubule-binding region") - pmid:23702978 + pmid:21427723 - p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3)) + p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") - pmid:23702978 + pmid:26631930 - a(MESH:Interferons) increases p(HGNC:AIM2) + p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163))) - pmid:23702978 + pmid:28855586 - a(MESH:Interferons) decreases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(Ac, Lys, 163)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) - pmid:23702978 + pmid:26192747 - a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac)) - pmid:23702978 + pmid:26631930 - m(HGNC:MIR223) decreases p(HGNC:NLRP3) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281))) - pmid:23702978 + pmid:28855586 - act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) - pmid:23702978 + pmid:28287136 - p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") + p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:23702978 + pmid:28287136 - p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates") - pmid:23702978 + pmid:28287136 - act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) partOf p(HBP:"VQIINK motif") - pmid:23702978 + pmid:27041503 - p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1) - pmid:23702978 + pmid:27041503 - p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1)) + p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"actin filament polymerization") - + + + pmid:26631930 + + p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369))) + - pmid:23702978 + pmid:28855586 - complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) + p(HGNC:MAPT, pmod(Ac, Lys, 369)) association composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac)) + + - pmid:23702978 + pmid:26192747 - complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) + p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf a(HBP:"microtubule-binding region") + + + pmid:26631930 + + p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259))) + + - pmid:23702978 + pmid:26631930 - p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) + p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:23702978 + pmid:26631930 - p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) + p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates") - pmid:23702978 + pmid:26192747 - p(HGNC:CARD17) decreases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac)) - pmid:23702978 + pmid:26192747 - p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf a(HBP:"microtubule-binding region") - + + + pmid:26631930 + + p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290))) + - pmid:23702978 + pmid:26631930 - p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:23702978 + pmid:26631930 - p(MGI:Mefv) decreases sec(p(MGI:Il1b)) + p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates") - + + + pmid:26631930 + + p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321))) + - pmid:23702978 + pmid:26631930 - composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) + p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24561250 + pmid:26631930 - path(MESH:Stroke) increases complex(GO:"inflammasome complex") + p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates") - + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac)) + - pmid:24561250 + pmid:26192747 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) + p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf a(HBP:"microtubule-binding region") - pmid:24561250 + pmid:28760828 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates") - pmid:24561250 + pmid:28760828 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) - pmid:24561250 + pmid:26631930 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353))) - pmid:24561250 + pmid:26631930 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph)) - pmid:24561250 + pmid:26631930 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) + p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:26631930 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) + p(HGNC:MAPT, pmod(Ac, Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26390242 - p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) - pmid:24561250 + pmid:26390242 - p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") + p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) - pmid:24561250 + pmid:26390242 - p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") + p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - pmid:24561250 + pmid:26390242 - p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") + p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases a(HBP:Neurodegeneration) - pmid:24561250 + pmid:29540553 - p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") + p(HGNC:MAPT, pmod(Ac, Lys, 174)) negativeCorrelation act(p(HGNC:SIRT1)) - pmid:24561250 + pmid:26631930 - p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") + p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26631930 - a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") + p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments") - pmid:24561250 + pmid:26631930 - a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - pmid:24561250 + pmid:26631930 - a(MESH:Alarmins) increases complex(GO:"inflammasome complex") + p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph)) - pmid:24561250 + pmid:26631930 - a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph)) - + + + pmid:26631930 + + p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") + - pmid:24561250 + pmid:26631930 - complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") + p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") - + + + pmid:26631930 + + p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + pmid:26631930 + + p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + + - pmid:24561250 + pmid:26631930 - complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - + + + pmid:19517062 + + p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product") + + + + pmid:19517062 + + p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates") + + - pmid:24561250 + pmid:26631930 - complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:deamidation)) increases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:26631930 - a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:26631930 - a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26631930 - a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) - pmid:24561250 + pmid:26631930 - a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:24561250 + pmid:16566606 - deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") - pmid:24561250 + pmid:22057784 - path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:24561250 + pmid:18562203 - path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) - pmid:24561250 + pmid:18562203 - path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18)) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:24561250 + pmid:17050703 - path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B)) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration)) - pmid:24561250 + pmid:16566606 - path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments") - pmid:24561250 + pmid:16566606 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pmid:17050703 - act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pmid:26631930 - act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) - pmid:27314526 + pmid:26631930 - act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:27314526 + pmid:16566606 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") - pmid:27314526 + pmid:22057784 - p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:24561250 + pmid:17050703 - p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") - pmid:24561250 + pmid:17050703 - p(MGI:P2rx4) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") - pmid:24561250 + pmid:17050703 - p(MGI:P2rx4) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") - pmid:24561250 + pmid:17050703 - p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration") - pmid:24561250 + pmid:17050703 - p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") - + + + pmid:17050703 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + - + + + pmid:16566606 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments") + - pmid:24561250 + pmid:16566606 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pmid:26631930 - p(HGNC:PANX1) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) - pmid:24561250 + pmid:26631930 - p(HGNC:PANX1) increases p(HGNC:IL18) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:24561250 + pmid:16566606 - a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") - pmid:24561250 + pmid:16566606 - a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments") - pmid:24561250 + pmid:16566606 - p(MGI:Nlrp3) increases p(MGI:Il1b) + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") + p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:24869773 - p(MGI:Nlrp3) increases a(MESH:Neuropathology) + p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:26631930 - p(MGI:Nlrp3) decreases bp(GO:cognition) + p(HGNC:MAPT, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") - + + + pmid:26631930 + + p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") + - pmid:24561250 + pmid:26631930 - composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) + p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) @@ -130700,201 +130989,15169 @@

Statements

+ + + + + + + + - pmid:24561250 + pmid:26631930 - composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) - pmid:24561250 + pmid:8391280 - a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") - pmid:24561250 + pmid:8391280 - a(CHEBI:probenecid) decreases p(HGNC:PANX1) + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) + + + + - pmid:24561250 + pmid:26631930 - a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) + + + + - pmid:24561250 + pmid:26631930 - a(CHEBI:probenecid) decreases p(HGNC:IL1B) + complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)")) + + + + - pmid:24561250 + pmid:26631930 - a(CHEBI:probenecid) decreases p(HGNC:IL18) + complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") - pmid:24561250 + pmid:26631930 - a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) + complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") - pmid:24561250 + pmid:26631930 - a(CHEBI:probenecid) increases bp(GO:learning) + p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) + p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates") - pmid:24561250 + pmid:26631930 - a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") + p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") - pmid:24561250 + pmid:26631930 - p(MGI:Casp1) increases a(MESH:Neuropathology) + p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) - pmid:24561250 + pmid:26631930 - p(MGI:Casp1) decreases bp(GO:cognition) + p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) - pmid:27314526 + pmid:26631930 - sec(a(MESH:Interleukins)) association path(MESH:Dementia) + p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") - pmid:27314526 + pmid:26631930 - sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) + p(HGNC:MAPT, var("p.Leu266Val")) decreases p(HBP:"4R tau") - pmid:27314526 + pmid:26631930 - bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") + p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau") - pmid:27314526 + pmid:26631930 - act(p(HGNC:PRSS3)) increases p(HGNC:IL18) + p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") - pmid:27314526 + pmid:26631930 - act(p(FPLX:ELA)) increases p(HGNC:IL18) + p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") - pmid:27314526 + pmid:17493042 - act(p(HGNC:CTSG)) increases p(HGNC:IL18) + p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2") - + + + pmid:17493042 + + p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") + - pmid:27314526 + pmid:28002468 - composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) - - - pmid:27314526 + pmid:28002468 - path(MESH:Periodontitis) decreases bp(GO:cognition) + p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) - + + + + pmid:11606569 + + p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pmid:11606569 + + p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:11606569 + + p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HBP:"VQIVYK motif") increases a(HBP:"Tau fibrils") + + + + + + + pmid:17493042 + + p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") + + + + + + + pmid:23531502 + + p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") + + + + + + + pmid:17493042 + + p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:23531502 + + p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:19363271 + + p(HBP:"VQIVYK motif") association p(FPLX:HSP90) + + + + + + + pmid:19363271 + + p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4") + + + + + + + pmid:19363271 + + p(HBP:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + + + + + + + pmid:23531502 + + p(HBP:"VQIVYK motif") positiveCorrelation p(HBP:"KXGS motif") + + + + + + + pmid:28002468 + + p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) + + + + + + + pmid:11606569 + + p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pmid:11606569 + + p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:11606569 + + p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates") + + + + + + + pmid:26903089 + + p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) + + + + + + + pmid:26631930 + + a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HGNC:YWHAZ) increases a(HBP:"Tau aggregates") + + + + + + + pmid:12551948 + + p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + + + + + + + pmid:12551948 + + p(HGNC:YWHAZ) association p(HGNC:MAPT) + + + + + + + pmid:12551948 + + p(HGNC:YWHAZ) association p(HGNC:GSK3B) + + + + + + + pmid:12551948 + + p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) + + + + + + + pmid:26631930 + + p(HGNC:MAPT, frag("151_391")) increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration) + + + + + + + pmid:26631930 + + p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") + + + + + + + pmid:26631930 + + p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) + + + + + + + pmid:26631930 + + p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates") + + + + + + + pmid:26631930 + + p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) + + + + + + + pmid:26631930 + + tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:26631930 + + p(HGNC:SPAST) increases bp(GO:"microtubule severing") + + + + + + + + + + + pmid:26631930 + + complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse")) + + + + + + + pmid:26631930 + + complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:26631930 + + p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) + + + + + + + + + pmid:21548880 + + p(HGNC:GRIN2B) negativeCorrelation p(HGNC:TTBK1) + + + + + + + + + + + pmid:22817713 + + complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pmid:22817713 + + complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") + + + + + + + pmid:22817713 + + bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) + + + + + + + pmid:22817713 + + a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers") + + + + + + + pmid:22817713 + + a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates") + + + + + + + pmid:22817713 + + p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pmid:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + + + + + + + pmid:26142647 + + act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) + + + + + + + pmid:21734277 + + act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + + + + + + + pmid:21734277 + + act(p(HGNC:PPP1CA)) increases act(p(HGNC:GSK3B)) + + + + + + + pmid:21734277 + + act(p(HGNC:PPP1CA)) negativeCorrelation bp(GO:"axonal transport") + + + + + + + pmid:25001178 + + act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:22817713 + + p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pmid:26671985 + + p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain") + + + + + + + pmid:26671985 + + p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) + + + + + + + + + + + pmid:22817713 + + composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pmid:29626319 + + p(FPLX:UBE2) increases deg(a(MESH:Proteins)) + + + + + + + pmid:29626319 + + a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) + + + + + + + pmid:29626319 + + p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) + + + + + + + pmid:29626319 + + a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process") + + + + + + + pmid:29626319 + + a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + + + + + + + pmid:29626319 + + a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + a(HP:"glymphatic system") decreases p(HGNC:MAPT) + + + + + + + pmid:29626319 + + p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) + + + + + + + pmid:29626319 + + p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:29626319 + + act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + + pmid:29626319 + + act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:23702978 + + act(p(FPLX:TLR)) increases p(HGNC:NLRP3) + + + + + + + pmid:23702978 + + act(p(FPLX:TLR)) increases p(HGNC:IL1B) + + + + + + + pmid:29626319 + + p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:ABCA7) association bp(GO:phagocytosis) + + + + + + + pmid:29626319 + + p(HGNC:ABCA7) regulates bp(GO:phagocytosis) + + + + + + + pmid:29626319 + + p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + p(HGNC:ABCA7) decreases p(HGNC:BACE1) + + + + + + + pmid:29626319 + + p(HGNC:CD33) association bp(GO:phagocytosis) + + + + + + + pmid:29626319 + + p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) + + + + + + + pmid:29626319 + + p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + p(HGNC:SLC2A1) increases p(HGNC:LRP1) + + + + + + + pmid:29626319 + + p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + + + + + + + pmid:29626319 + + p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) + + + + + + + pmid:29626319 + + p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") + + + + + + + pmid:29626319 + + a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") + + + + + + + pmid:29626319 + + p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) + + + + + + + pmid:29626319 + + p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta") + + + + + + + + + pmid:29626319 + + complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + + + pmid:29626319 + + a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta") + + + + + + + + + + + pmid:29626319 + + complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + + + pmid:29626319 + + composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta") + + + + + + + + + pmid:29626319 + + a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) + + + + + + + pmid:29626319 + + a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) + + + + + + + pmid:29626319 + + a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") + + + + + + + pmid:29626319 + + a(MESH:tenuigenin) increases p(HGNC:PSMD7) + + + + + + + pmid:29626319 + + bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) + + + + + + + pmid:29626319 + + a(CHEBI:wogonin) increases bp(GO:autophagy) + + + + + + + pmid:29626319 + + a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:29626319 + + p(HGNC:NPAS4) increases bp(GO:autophagy) + + + + + + + pmid:29626319 + + p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) + + + + + + + pmid:29626319 + + p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph))) + + + + + + + pmid:29626319 + + a(CHEBI:statin) increases sec(p(HGNC:IDE)) + + + + + + + pmid:29626319 + + a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) + + + + + + + pmid:29626319 + + a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) + + + + + + + pmid:29626319 + + a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) + + + + + + + pmid:29626319 + + a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:atorvastatin) increases sec(p(HGNC:MME)) + + + + + + + pmid:29626319 + + a(CHEBI:nobiletin) increases act(p(HGNC:MME)) + + + + + + + pmid:29626319 + + a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) + + + + + + + pmid:29626319 + + a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) + + + + + + + pmid:29626319 + + a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) + + + + + + + pmid:29626319 + + a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) + + + + + + + pmid:29626319 + + p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + p(HGNC:ANXA1) increases act(p(HGNC:MME)) + + + + + + + pmid:29626319 + + a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + + + + + pmid:29626319 + + complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:29626319 + + a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29626319 + + a(CHEBI:oleocanthal) increases p(HGNC:LRP1) + + + + + + + pmid:29626319 + + a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) + + + + + + + + + + + pmid:29238289 + + complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) + + + + + + + pmid:29238289 + + complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) decreases a(MESH:Neurons) + + + + + + + + + + + pmid:29238289 + + complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) decreases p(HGNC:MAPT) + + + + + + + pmid:29238289 + + p(HGNC:SNAP23) increases p(HGNC:MAPT) + + + + + + + pmid:29238289 + + p(MESH:"SNARE Proteins") increases p(HGNC:MAPT) + + + + + + + pmid:29238289 + + p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) + + + + + + + pmid:29238289 + + p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") + + + + + + + pmid:29238289 + + a(MESH:"Transport Vesicles") association p(HGNC:MAPT) + + + + + + + + + + + pmid:17493042 + + a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pmid:23531502 + + a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pmid:10537045 + + a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pmid:26751493 + + a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pmid:17493042 + + a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) + + + + + + + pmid:17493042 + + a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + + + + + + + pmid:21757739 + + a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") + + + + + + + pmid:21757739 + + a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) + + + + + + + pmid:1918161 + + a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) + + + + + + + pmid:10537045 + + a(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) + + + + + + + pmid:26751493 + + a(HBP:"microtubule-binding region") association p(HGNC:HDAC6) + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305")) + + + + + + + pmid:23407988 + + p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau") + + + + + + + pmid:23407988 + + p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") + + + + + + + pmid:2123288 + + p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM) + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:23531502 + + p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336")) + + + + + + + pmid:23407988 + + p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau") + + + + + + + pmid:23407988 + + p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") + + + + + + + pmid:23832849 + + p(HBP:"tubulin-binding repeat 3") increases a(HBP:"Tau aggregates") + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367")) + + + + + + + pmid:17493042 + + p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + + + + + + + pmid:23407988 + + p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau") + + + + + + + pmid:17493042 + + a(HBP:"projection domain") partOf p(HGNC:MAPT) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") partOf p(HGNC:MAPT) + + + + + + + pmid:17493042 + + a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") + + + + + + + pmid:17493042 + + a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:LCK) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:FGR) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:SRC) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:GRB2) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(FPLX:PLC) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:PIN1) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:FYN) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(HGNC:DLG4) + + + + + + + pmid:26751493 + + a(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") + + + + + + + pmid:17493042 + + p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain") + + + + + + + pmid:8391280 + + p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) + + + + + + + pmid:8391280 + + p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT) + + + + + + + pmid:12551948 + + p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT) + + + + + + + pmid:12551948 + + p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") + + + + + + + pmid:12551948 + + p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane")) + + + + + + + pmid:17493042 + + p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1") + + + + + + + pmid:17493042 + + p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2") + + + + + + + pmid:17493042 + + p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3") + + + + + + + pmid:17493042 + + p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4") + + + + + + + pmid:17493042 + + p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") + + + + + + + pmid:17493042 + + p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain") + + + + + + + + + + + pmid:17493042 + + p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + + + + + + + pmid:17493042 + + bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + + + + + + + pmid:21757739 + + a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain") + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain") + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain") + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain") + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2") + + + + + + + pmid:21757739 + + a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") + + + + + + + pmid:22033876 + + a(HBP:"proline-rich domain") association act(p(FPLX:Actin)) + + + + + + + pmid:22033876 + + a(HBP:"proline-rich domain") association p(INTERPRO:"SH3 domain") + + + + + + + pmid:21757739 + + p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain") + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198")) + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain") + + + + + + + pmid:21757739 + + a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain") + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1") + + + + + + + pmid:21757739 + + p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain") + + + + + + + + + + + pmid:27260836 + + complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") + + + + + + + pmid:27260836 + + p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex") + + + + + + + pmid:27260836 + + p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex") + + + + + + + pmid:27260836 + + p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex") + + + + + + + pmid:27260836 + + p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex") + + + + + + + pmid:27260836 + + p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex") + + + + + + + pmid:11943212 + + a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MARK4, pmod(Ph)) + + + + + + + pmid:11943212 + + a(HBP:"granulovacuolar degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:27260836 + + complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pmid:26655600 + + complex(GO:"Pick body") positiveCorrelation p(HBP:"3R tau") + + + + + + + pmid:24368848 + + p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") + + + + + + + pmid:23407988 + + a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") + + + + + + + pmid:23407988 + + a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:23407988 + + a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:23407988 + + a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:23407988 + + a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:23407988 + + a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:23407988 + + act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") + + + + + + + pmid:22253473 + + a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") + + + + + + + pmid:23407988 + + complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) association p(HGNC:NGFR) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) isA p(HGNC:RAC1) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) + + + + + + + pmid:22142809 + + p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") + + + + + + + pmid:27087442 + + act(p(HBP:RAC1b)) negativeCorrelation p(MGI:Cdk5) + + + + + + + pmid:27087442 + + act(p(HBP:RAC1b)) positiveCorrelation act(a(MESH:Neurons)) + + + + + + + pmid:27796283 + + act(p(HGNC:RAC1)) increases bp(GO:"dendritic spine development") + + + + + + + pmid:22142809 + + p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) + + + + + + + pmid:22142809 + + p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) + + + + + + + pmid:22142809 + + a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) + + + + + + + pmid:6543144 + + complex(GO:microtubule) association p(HGNC:MAPT) + + + + + + + pmid:10464280 + + complex(GO:microtubule) association p(HGNC:MAPT) + + + + + + + pmid:19491104 + + complex(GO:microtubule) association p(HGNC:KIF5B) + + + + + + + pmid:10464280 + + act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") + + + + + + + pmid:10464280 + + complex(GO:microtubule) association p(HGNC:PPP2CA) + + + + + + + pmid:10464280 + + act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pmid:18500754 + + act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) + + + + + + + pmid:18500754 + + complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") + + + + + + + pmid:20133804 + + complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") + + + + + + + pmid:1918161 + + p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule) + + + + + + + pmid:1918161 + + p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT) + + + + + + + pmid:1918161 + + p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") + + + + + + + pmid:1918161 + + complex(GO:axon) positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:26671985 + + act(complex(GO:axon)) negativeCorrelation a(HBP:neurotoxicity) + + + + + + + pmid:1918161 + + complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:17187063 + + p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) + + + + + + + pmid:17187063 + + a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pmid:19251756 + + a(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pmid:22952452 + + a(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:6543144 + + complex(GO:neurofilament) association p(HGNC:MAPT) + + + + + + + pmid:2446784 + + complex(GO:"polysomal ribosome") association p(HGNC:MAPT) + + + + + + + pmid:11812770 + + p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT) + + + + + + + + + pmid:11812770 + + complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) + + + + + + + + + pmid:11812770 + + complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:18680553 + + p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN) + + + + + + + pmid:18680553 + + p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT) + + + + + + + pmid:18680553 + + bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) + + + + + + + pmid:18680553 + + bp(GO:myelination) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC) + + + + + + + pmid:18467332 + + p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") + + + + + + + pmid:18467332 + + p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) + + + + + + + pmid:18467332 + + p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) + + + + + + + pmid:22033876 + + p(INTERPRO:"SH3 domain") association a(HBP:"proline-rich domain") + + + + + + + + + + + pmid:18467332 + + p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1) + + + + + + + pmid:18467332 + + p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") + + + + + + + + + + + pmid:18467332 + + p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) + + + + + + + pmid:18467332 + + p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2) + + + + + + + pmid:18467332 + + p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + + + + + + + + + + + pmid:18467332 + + complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) + + + + + + + pmid:18467332 + + p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) + + + + + + + pmid:18467332 + + p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) + + + + + + + pmid:18467332 + + p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1) + + + + + + + pmid:18467332 + + p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + + + + + + + + + pmid:18467332 + + p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + + + + + + + + + + + pmid:19491104 + + bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) + + + + + + + pmid:19491104 + + p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph)) + + + + + + + pmid:19491104 + + act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + + + + + + + pmid:19491104 + + act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + + + + + + + + + + + + + + + + + pmid:10464280 + + rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + + + + + + + pmid:18500754 + + p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region") + + + + + + + pmid:19363271 + + a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + + + + + + + pmid:14612456 + + complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + + + + + + + + + + + + + pmid:8391280 + + p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") + + + + + + + pmid:8391280 + + p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + + + + + + + pmid:8391280 + + act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) + + + + + + + + + + + pmid:8391280 + + complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) + + + + + + + pmid:8391280 + + g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pmid:8391280 + + g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + + + + + + + + + + + pmid:16176937 + + p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + + + + + + + pmid:16176937 + + p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") + + + + + + + + + + + pmid:16176937 + + p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + + + + + + + pmid:16176937 + + p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") + + + + + + + pmid:16176937 + + p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) + + + + + + + pmid:16176937 + + p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + + + + + + + pmid:16176937 + + p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") + + + + + + + + + + + pmid:16176937 + + p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + + + + + + + pmid:10391244 + + p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + pmid:10391244 + + act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + + + + + + + + + + + pmid:10391244 + + complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) + + + + + + + pmid:10391244 + + complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") + + + + + + + pmid:10391244 + + complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT)) + + + + + + + pmid:10391244 + + p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) + + + + + + + pmid:20133804 + + p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) + + + + + + + pmid:20133804 + + p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) + + + + + + + pmid:20133804 + + p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) + + + + + + + pmid:20133804 + + p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") + + + + + + + + + + + pmid:20133804 + + p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) + + + + + + + pmid:20133804 + + p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) + + + + + + + pmid:20133804 + + p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) + + + + + + + + + + + pmid:20071522 + + complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) + + + + + + + + + + + pmid:2123288 + + p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2") + + + + + + + pmid:2123288 + + act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) + + + + + + + pmid:2123288 + + act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") + + + + + + + pmid:27133022 + + act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + + + + + + + pmid:27133022 + + act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2)) + + + + + + + + + + + pmid:2123288 + + complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + + + + + + + + + + + pmid:2123288 + + complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + + + + + + + + + + + + + pmid:2123288 + + complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pmid:2833519 + + p(HGNC:S100B) association p(HGNC:MAPT) + + + + + + + pmid:2833519 + + p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + + + + + + + pmid:2833519 + + act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + + + + + + + pmid:18494933 + + p(HGNC:S100B) increases act(p(HGNC:AGER)) + + + + + + + pmid:18494933 + + p(HGNC:S100B) directlyIncreases act(p(HGNC:AGER)) + + + + + + + pmid:18494933 + + p(HGNC:S100B) increases p(FPLX:JNK) + + + + + + + pmid:18494933 + + p(HGNC:S100B) increases p(FPLX:JNK, pmod(Ph)) + + + + + + + pmid:18494933 + + p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") + + + + + + + pmid:18494933 + + p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph)) + + + + + + + + + + + pmid:2833519 + + complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + + + + + + + pmid:2833519 + + act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:12714745 + + g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") + + + + + + + pmid:12714745 + + g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") + + + + + + + pmid:12714745 + + complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) + + + + + + + + + + + pmid:12714745 + + composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle") + + + + + + + pmid:12714745 + + composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body") + + + + + + + + + + + + + pmid:12551948 + + act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection") + + + + + + + pmid:21339331 + + p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:21339331 + + p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + + + + + + + pmid:21339331 + + p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:21339331 + + p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:21339331 + + p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + + + + + + + pmid:17078951 + + p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA) + + + + + + + pmid:17078951 + + p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 212))) + + + + + + + pmid:22072628 + + p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + + + + + + + pmid:21339331 + + p(HGNC:ANXA2) association p(HGNC:MAPT) + + + + + + + pmid:21339331 + + p(HGNC:ANXA2) association a(MESH:"Cell Membrane") + + + + + + + pmid:21339331 + + p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + + + + + + + + + + + + + pmid:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm)) + + + + + + + pmid:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt) + + + + + + + pmid:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn) + + + + + + + pmid:18096814 + + p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + + + + + + + pmid:21131359 + + bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + + + + + + + pmid:21131359 + + bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pmid:21131359 + + bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:21131359 + + bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") + + + + + + + pmid:8226987 + + bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:19732809 + + bp(MESH:"Hot Temperature") association a(HBP:"O-GlcNAcylation") + + + + + + + + + + + pmid:21131359 + + a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) + + + + + + + pmid:21131359 + + a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + + + + + + + pmid:8985176 + + a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph)) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) + + + + + + + pmid:28173111 + + r(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) + + + + + + + pmid:28173111 + + act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + complex(GO:mitochondrion) positiveCorrelation p(MGI:Nrf1) + + + + + + + pmid:28173111 + + complex(GO:mitochondrion) positiveCorrelation p(MGI:Nfe2l2) + + + + + + + pmid:28173111 + + complex(GO:mitochondrion) positiveCorrelation p(MGI:Ppargc1a) + + + + + + + pmid:28173111 + + bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syp) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Dlg4) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn1) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Syn2) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Synpo2) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Nrgn) + + + + + + + pmid:28173111 + + act(complex(GO:"neuron to neuron synapse")) positiveCorrelation r(MGI:Gap43) + + + + + + + pmid:28173111 + + r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Syp) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Dlg4) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Syn1) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Syn2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Syn2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Synpo2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Synpo2) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Nrgn) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + r(MGI:Gap43) positiveCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pmid:28173111 + + r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Fis1) positiveCorrelation bp(GO:"mitochondrial fission") + + + + + + + pmid:28173111 + + bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Fis1) + + + + + + + pmid:28173111 + + bp(GO:"mitochondrial fission") positiveCorrelation p(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Dnm1l) positiveCorrelation bp(GO:"mitochondrial fission") + + + + + + + pmid:28173111 + + r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Ppid) positiveCorrelation complex(GO:"mitochondrial matrix") + + + + + + + pmid:28173111 + + complex(GO:"mitochondrial matrix") positiveCorrelation p(MGI:Ppid) + + + + + + + pmid:28173111 + + r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Mfn1) positiveCorrelation bp(GO:"mitochondrial fusion") + + + + + + + pmid:28173111 + + r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Mfn2) positiveCorrelation bp(GO:"mitochondrial fusion") + + + + + + + pmid:28173111 + + r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Opa1) positiveCorrelation bp(GO:"mitochondrial fusion") + + + + + + + pmid:28173111 + + bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn1) + + + + + + + pmid:28173111 + + bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Mfn2) + + + + + + + pmid:28173111 + + bp(GO:"mitochondrial fusion") positiveCorrelation p(MGI:Opa1) + + + + + + + pmid:28173111 + + r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Nrf1) positiveCorrelation complex(GO:mitochondrion) + + + + + + + pmid:28173111 + + r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Nfe2l2) positiveCorrelation complex(GO:mitochondrion) + + + + + + + pmid:28173111 + + r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Ppargc1a) positiveCorrelation complex(GO:mitochondrion) + + + + + + + pmid:25987199 + + act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) + + + + + + + pmid:28173111 + + r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:28173111 + + p(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:26671985 + + p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pmid:26671985 + + p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation p(HBP:neurotoxicity) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) + + + + + + + pmid:24844691 + + p(FPLX:Tubulin, pmod(Ac)) negativeCorrelation act(p(HGNC:HDAC6)) + + + + + + + + + + + pmid:25974414 + + act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + + + + + + + pmid:25974414 + + act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + + + + + + + pmid:25974414 + + act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + + + + + + + pmid:25974414 + + act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + + + + + + + pmid:25974414 + + p(HGNC:MAPT, pmod(Ph, Thr, 17)) isA p(HGNC:MAPT) + + + + + + + pmid:25974414 + + act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 17)) + + + + + + + pmid:16566606 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") + + + + + + + pmid:22057784 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pmid:22057784 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") + + + + + + + pmid:22057784 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") + + + + + + + pmid:17050703 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + + + + + + + pmid:16566606 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments") + + + + + + + pmid:16566606 + + p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pmid:26671985 + + a(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon)) + + + + + + + pmid:26671985 + + p(HBP:"phosphatase-activating domain") positiveCorrelation act(a(HBP:"Tau oligomers")) + + + + + + + pmid:26671985 + + p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) + + + + + + + pmid:26671985 + + p(HBP:"phosphatase-activating domain") decreases act(complex(GO:axon)) + + + + + + + pmid:26671985 + + p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pmid:26671985 + + p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport") + + + + + + + pmid:27260838 + + p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1") + + + + + + + pmid:27260838 + + p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2") + + + + + + + pmid:27260838 + + p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:pretangles) + + + + + + + pmid:27574109 + + p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau") + + + + + + + pmid:27373205 + + p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:21734277 + + p(HBP:"phosphatase-activating domain") directlyIncreases act(p(HGNC:PPP1CA)) + + + + + + + pmid:26671985 + + p(HBP:neurotoxicity) positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me2, Lys, 311)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 259)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 290)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2") + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 353)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT) + + + + + + + pmid:24869773 + + p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 163)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf a(HBP:"proline-rich domain") + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 174)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf a(HBP:"proline-rich domain") + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 180)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf a(HBP:"proline-rich domain") + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 254)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1") + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Ub, Lys, 254)) association p(HGNC:MAPT) + + + + + + + pmid:8391280 + + p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 267)) association p(HGNC:MAPT) + + + + + + + pmid:22033876 + + p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1") + + + + + + + + + pmid:23943618 + + complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) + + + + + + + + + pmid:23943618 + + complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) increases a(HBP:"Tau epitope, PHF1") + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) negativeCorrelation a(CHEBI:"folate(2-)") + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) + + + + + + + pmid:22764226 + + act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) + + + + + + + pmid:22764226 + + a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) + + + + + + + pmid:22764226 + + a(CHEBI:"folate(2-)") negativeCorrelation act(a(CHEBI:"L-dopa")) + + + + + + + pmid:22764226 + + p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation a(HBP:"Tau epitope, PHF1") + + + + + + + + + + + pmid:25143394 + + p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:25681682 + + bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) + + + + + + + pmid:24183963 + + p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:24183963 + + p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + + + + + + + pmid:25987199 + + act(p(HGNC:GLP1R)) decreases bp(MESH:"Oxidative Stress") + + + + + + + pmid:25987199 + + act(p(HGNC:GLP1R)) increases act(a(GO:mitochondrion)) + + + + + + + pmid:23531502 + + a(CHEBI:cinnamaldehyde) decreases p(HBP:"KXGS motif") + + + + + + + pmid:23531502 + + a(CHEBI:cinnamaldehyde) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:23531502 + + a(CHEBI:cinnamaldehyde) causesNoChange bp(GO:"microtubule polymerization") + + + + + + + pmid:23531502 + + a(CHEBI:cinnamaldehyde) decreases act(a(CHEBI:"hydrogen peroxide")) + + + + + + + pmid:23531502 + + p(HBP:"KXGS motif") positiveCorrelation p(HBP:"VQIVYK motif") + + + + + + + pmid:25031639 + + p(HBP:"KXGS motif") increases a(GO:"neurofibrillary tangle") + + + + + + + pmid:23531502 + + a(CHEBI:"(-)-epicatechin") decreases p(HBP:"KXGS motif") + + + + + + + pmid:23531502 + + a(CHEBI:"(-)-epicatechin") decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:23531502 + + a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) + + + + + + + pmid:23531502 + + a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) + + + + + + + + + + + pmid:23531502 + + complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein)) + + + + + + + pmid:23531502 + + act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:17082178 + + a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") + + + + + + + pmid:23531502 + + act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pmid:23531502 + + act(a(CHEBI:acrolein)) decreases a(MESH:Neurons) + + + + + + + pmid:23531502 + + act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26655600 + + p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:glycation)) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) decreases bp(GO:"canonical glycolysis") + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE") + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) decreases p(HGNC:APP, frag("672_713")) + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) + + + + + + + pmid:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) + + + + + + + pmid:19251756 + + bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:26304819 + + r(HGNC:GAPDH) association bp(GO:"apoptotic process") + + + + + + + pmid:26304819 + + a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product") + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + + + + + + + pmid:28176663 + + a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:28176663 + + a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:28176663 + + a(CHEBI:"D-ribose") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 287)) + + + + + + + pmid:26095350 + + a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 306)) + + + + + + + pmid:19517062 + + a(CHEBI:"D-ribose") increases p(HBP:"Tau aggregates") + + + + + + + pmid:19517062 + + a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation)) + + + + + + + pmid:28176663 + + a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") + + + + + + + pmid:26095350 + + p(MGI:Mapt, pmod(Ph, Ser, 214)) positiveCorrelation a(CHEBI:"D-ribose") + + + + + + + pmid:26095350 + + p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) positiveCorrelation a(CHEBI:"D-ribose") + + + + + + + pmid:26095350 + + p(MGI:Camk2b, pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) + + + + + + + + + + + pmid:26095350 + + p(MGI:Camk2b, pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") + + + + + + + pmid:22798221 + + a(CHEBI:methylglyoxal) increases p(HGNC:AGER) + + + + + + + pmid:19251756 + + a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pmid:17082178 + + a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:22798221 + + act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + + + + + + + pmid:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:"D-glyceraldehyde 3-phosphate"))) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") + + + + + + + pmid:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(HBP:Neurodegeneration) + + + + + + + + + + + + + pmid:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) + + + + + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) isA p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT) + + + + + + + pmid:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) + + + + + + + + + + + pmid:19251756 + + complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta") + + + + + + + pmid:19251756 + + complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle") + + + + + + + pmid:16630055 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates") + + + + + + + pmid:19732809 + + p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:16630055 + + path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + + + + + + + pmid:16630055 + + path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph)) + + + + + + + pmid:16630055 + + path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) + + + + + + + pmid:12578227 + + p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:12578227 + + p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13") + + + + + + + pmid:12578227 + + r(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) + + + + + + + pmid:12578227 + + p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:9099822 + + act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:12578227 + + p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13") + + + + + + + pmid:10537045 + + p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:10537045 + + p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + + + + + + + pmid:10537045 + + act(p(HGNC:TGM2)) association a(HBP:"microtubule-binding region") + + + + + + + pmid:11089576 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pmid:11089576 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:11738469 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:8985134 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:11738469 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:8985134 + + act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + + pmid:10537045 + + complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") + + + + + + + pmid:10537045 + + a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)") + + + + + + + pmid:10537045 + + a(HBP:maitotoxin) increases act(p(HGNC:TGM2)) + + + + + + + pmid:22057784 + + p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pmid:17768677 + + p(MGI:Mapt, pmod(HBP:nitration, Tyr, 488)) causesNoChange act(p(MGI:Mapt)) + + + + + + + pmid:17768677 + + p(MGI:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) + + + + + + + pmid:16816118 + + a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) + + + + + + + pmid:16816118 + + a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome")) + + + + + + + pmid:16816118 + + p(RGD:Mapt, pmod(HBP:nitration)) negativeCorrelation act(p(HBP:"20 S Proteasome")) + + + + + + + + + pmid:27796283 + + act(p(HGNC:RHOA)) decreases bp(GO:"dendritic spine development") + + + + + + + pmid:27796283 + + act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") + + + + + + + pmid:27796283 + + act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + + + + + + + pmid:27796283 + + bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") + + + + + + + pmid:27796283 + + p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1)) + + + + + + + pmid:27796283 + + p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7")) + + + + + + + + + pmid:27796283 + + act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1)) + + + + + + + pmid:27796283 + + p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) + + + + + + + pmid:27796283 + + p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7)) + + + + + + + + + pmid:27796283 + + act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) + + + + + + + pmid:27796283 + + complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) + + + + + + + pmid:27796283 + + act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + + + + + + + pmid:27796283 + + act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + + + + + + + pmid:27796283 + + act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) + + + + + + + + + pmid:27796283 + + p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") + + + + + + + pmid:27796283 + + p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") + + + + + + + + + + + pmid:27796283 + + complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) + + + + + + + pmid:27796283 + + p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV)) + + + + + + + + + + + + + pmid:29121589 + + complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) increases p(HGNC:NFE2L2, pmod(UbPoly)) + + + + + + + pmid:29121589 + + p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + + + + + + + pmid:29121589 + + p(HGNC:NFE2L2, pmod(UbPoly)) increases deg(p(HGNC:NFE2L2)) + + + + + + + pmid:29121589 + + p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + + + + + + + pmid:29121589 + + p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + + + + + + + pmid:29121589 + + p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27") + + + + + + + + + + + + + pmid:29121589 + + complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(UbPoly)) + + + + + + + pmid:29121589 + + p(HGNC:DPYSL2, pmod(Ph)) negativeCorrelation a(CHEBI:"dimethyl fumarate") + + + + + + + + + pmid:24401760 + + a(HBP:Astrogliosis) biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pmid:29121589 + + r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") + + + + + + + pmid:29121589 + + r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") + + + + + + + pmid:27807169 + + p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) + + + + + + + pmid:27807169 + + p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") + + + + + + + pmid:27807169 + + p(RGD:Cdk5r2) positiveCorrelation a(GO:synapse) + + + + + + + pmid:21489990 + + act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:21489990 + + act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:21489990 + + act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) + + + + + + + + + + + + + + + pmid:7514173 + + a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:7514173 + + a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:17078951 + + p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA) + + + + + + + pmid:17078951 + + p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf complex(p(HGNC:CDK5), p(HGNC:MAPT, pmod(Ph, Thr, 217))) + + + + + + + pmid:22072628 + + p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + + + + + + + + + + + + + + + + + + + + + + + + + + + pmid:9089387 + + p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) + + + + + + + pmid:9089387 + + act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) + + + + + + + + + pmid:22102280 + + a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:22102280 + + a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:22102280 + + a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:10998059 + + a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:10998059 + + a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:10998059 + + a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) + + + + + + + pmid:10998059 + + a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) + + + + + + + pmid:11013232 + + a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:10998059 + + act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph)) + + + + + + + pmid:26400044 + + act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Wasf1, pmod(Ph)) + + + + + + + pmid:26400044 + + act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Dpysl2, pmod(Ph)) + + + + + + + pmid:24808823 + + p(MGI:Cdk5) negativeCorrelation bp(GO:learning) + + + + + + + pmid:27087442 + + p(MGI:Cdk5) negativeCorrelation p(MGI:Cdk5r1) + + + + + + + pmid:27087442 + + p(MGI:Cdk5) negativeCorrelation act(p(HBP:RAC1b)) + + + + + + + pmid:27087442 + + p(MGI:Cdk5) negativeCorrelation path(MESH:Cognition) + + + + + + + pmid:27087442 + + p(MGI:Cdk5) negativeCorrelation act(a(MESH:Neurons)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(HBP:"Tau epitope, AT8") + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400)) + + + + + + + pmid:14642273 + + act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403)) + + + + + + + + + pmid:8702879 + + p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + + + pmid:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) + + + + + + + + + + + pmid:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) + + + + + + + + + pmid:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) + + + + + + + + + pmid:8702879 + + p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + pmid:8702879 + + p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + pmid:26400044 + + p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + + + + + + + + + pmid:26400044 + + p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) + + + + + + + + + + + + + + + pmid:26400044 + + complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") + + + + + + + pmid:8726973 + + a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5)) + + + + + + + pmid:8726973 + + a(HBP:olomoucine) decreases act(p(HGNC:CDK5)) + + + + + + + pmid:18239272 + + p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:25673844 + + p(HGNC:CSNK1D) isA p(FPLX:CSNK1) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:18239272 + + p(HGNC:TTBK1) association a(HBP:pretangles) + + + + + + + pmid:20096481 + + p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) + + + + + + + pmid:20096481 + + p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:21548880 + + p(HGNC:TTBK1) increases p(HGNC:CDK5R1) + + + + + + + pmid:21548880 + + p(HGNC:TTBK1) positiveCorrelation act(p(ECCODE:"3.4.22.52")) + + + + + + + pmid:21548880 + + p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2B) + + + + + + + pmid:21548880 + + p(HGNC:TTBK1) negativeCorrelation p(HGNC:GRIN2D) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily") + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + + + + + + + pmid:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + + + + + + + pmid:25473830 + + p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) + + + + + + + pmid:25473830 + + p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pmid:23687953 + + act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + + + + + + + pmid:20096481 + + g(DBSNP:rs2651206) association path(MESH:"Alzheimer Disease") + + + + + + + pmid:21548880 + + g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:20096481 + + g(DBSNP:rs2651206) association g(HGNC:TTBK1) + + + + + + + pmid:21548880 + + g(DBSNP:rs2651206) isA g(HGNC:TTBK1) + + + + + + + pmid:20096481 + + g(DBSNP:rs10807287) association path(MESH:"Alzheimer Disease") + + + + + + + pmid:20096481 + + g(DBSNP:rs10807287) association g(HGNC:TTBK1) + + + + + + + pmid:20096481 + + g(DBSNP:rs7764257) association path(MESH:"Alzheimer Disease") + + + + + + + pmid:20096481 + + g(DBSNP:rs7764257) association g(HGNC:TTBK1) + + + + + + + pmid:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs2651206) + + + + + + + pmid:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs10807287) + + + + + + + pmid:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs7764257) + + + + + + + pmid:2820993 + + act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin)) + + + + + + + pmid:21548880 + + path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) + + + + + + + pmid:21548880 + + path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) + + + + + + + pmid:21548880 + + path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin)) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) + + + + + + + pmid:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin)) + + + + + + + pmid:21548880 + + act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(HGNC:TTBK1) + + + + + + + pmid:21548880 + + p(HGNC:GRIN2D) negativeCorrelation p(HGNC:TTBK1) + + + + + + + pmid:25673844 + + p(HGNC:VRK2) isA p(HBP:"CK1 superfamily") + + + + + + + pmid:25673844 + + p(HGNC:VRK3) isA p(HBP:"CK1 superfamily") + + + + + + + pmid:25673844 + + p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) + + + + + + + pmid:25673844 + + p(HGNC:CSNK1E) isA p(FPLX:CSNK1) + + + + + + + pmid:25673844 + + p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) + + + + + + + pmid:25673844 + + p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) + + + + + + + pmid:25673844 + + p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) + + + + + + + + + + + + + + + + + + + + + pmid:25673844 + + p(HGNC:SV2A, pmod(Ph, Thr, 84)) association p(HGNC:SYT1) + + + + + + + pmid:25673844 + + p(HGNC:SYT1) association p(HGNC:SV2A, pmod(Ph, Thr, 84)) + + + + + + + + + pmid:27607061 + + surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A)) + + + + + + + pmid:26323690 + + p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") + + + + + + + + + pmid:26323690 + + act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") + + + + + + + pmid:26323690 + + bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) + + + + + + + pmid:26323690 + + p(HGNC:CEP164) association p(HGNC:TTBK2) + + + + + + + pmid:26323690 + + p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2)) + + + + + + + + + pmid:26323690 + + p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + pmid:26323690 + + p(HGNC:MAPRE1) association p(HGNC:TTBK2) + + + + + + + pmid:26323690 + + p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + + + + + + + pmid:26323690 + + complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) + + + + + + + pmid:26323690 + + p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + pmid:24808823 + + p(MGI:Ttbk1) negativeCorrelation bp(GO:learning) + + + + + + + pmid:24808823 + + p(MGI:Ttbk1) increases a(HBP:pretangles) + + + + + + + pmid:24808823 + + p(MGI:Ttbk1) increases bp(GO:"neuron death") + + + + + + + pmid:24808823 + + surf(p(MGI:Grin2b)) positiveCorrelation bp(GO:learning) + + + + + + + + + pmid:11943212 + + p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:11943212 + + p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2") + + + + + + + pmid:26751493 + + p(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") + + + + + + + pmid:26751493 + + p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:11943212 + + p(HGNC:MARK4, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:11943212 + + p(HGNC:MARK4, pmod(Ph)) positiveCorrelation a(HBP:"granulovacuolar degeneration") + + + + + + + + + pmid:22692785 + + p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc) + + + + + + + pmid:23666762 + + p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:22156579 + + p(HGNC:MARK4) increases a(HBP:"Tau epitope, 12E8") + + + + + + + pmid:22156579 + + p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) + + + + + + + pmid:22156579 + + p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) + + + + + + + pmid:22156579 + + p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") + + + + + + + pmid:22156579 + + p(HGNC:MARK4) negativeCorrelation a(GO:synapse) + + + + + + + pmid:22692785 + + p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4) + + + + + + + pmid:22692785 + + p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22156579 + + p(INTERPRO:"Kinase associated domain 1 (KA1)") positiveCorrelation act(a(HBP:"amyloid-beta oligomers")) + + + + + + + pmid:22156579 + + act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22156579 + + act(p(INTERPRO:"Kinase associated domain 1 (KA1)"), ma(kin)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + + + + + + + pmid:16973293 + + p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") + + + + + + + pmid:16973293 + + p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) + + + + + + + pmid:16973293 + + bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)") + + + + + + + pmid:23666762 + + p(HBP:"Tau antibody, AGG5759") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:23666762 + + p(HBP:"Tau antibody, Tau-13") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:23666762 + + p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin)) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713"))) + + + + + + + pmid:27094130 + + act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713"))) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_711"))) + + + + + + + pmid:27094130 + + act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_711"))) + + + + + + + + + + + + + pmid:27094130 + + act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) + + + + + + + pmid:27068745 + + act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") + + + + + + + pmid:25899010 + + p(HGNC:DAPK1) positiveCorrelation a(HBP:Excitotoxicity) + + + + + + + pmid:25899010 + + p(HGNC:DAPK1) negativeCorrelation p(HGNC:PIN1) + + + + + + + pmid:27795443 + + act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) + + + + + + + pmid:27795443 + + act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") + + + + + + + pmid:24853415 + + p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) + + + + + + + pmid:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + pmid:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + pmid:24853415 + + p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:21311567 + + p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) + + + + + + + pmid:21311567 + + p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) + + + + + + + pmid:21311567 + + p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("637_1423")) association p(HGNC:APP) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("848_1423")) association p(HGNC:APP) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("1271_1423")) association p(HGNC:APP) + + + + + + + pmid:27094130 + + p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") + + + + + + + pmid:27094130 + + p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) + + + + + + + pmid:27094130 + + p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) + + + + + + + pmid:27068745 + + p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) + + + + + + + pmid:27068745 + + p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(kin)) + + + + + + + pmid:27068745 + + p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") + + + + + + + + + pmid:27068745 + + p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") + + + + + + + pmid:27068745 + + p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) + + + + + + + pmid:27068745 + + p(HGNC:CALML5) decreases p(HGNC:UNC5C, var("p.Thr835Met")) + + + + + + + pmid:27068745 + + act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) + + + + + + + pmid:27068745 + + act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) + + + + + + + pmid:27068745 + + act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) + + + + + + + pmid:27068745 + + act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) + + + + + + + pmid:27068745 + + act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) + + + + + + + pmid:27068745 + + p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK)) + + + + + + + pmid:27795443 + + act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") + + + + + + + pmid:27795443 + + act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) + + + + + + + pmid:27133022 + + p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) + + + + + + + pmid:27133022 + + p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) + + + + + + + pmid:27133022 + + p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM)) + + + + + + + pmid:27133022 + + act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + + + + + + + pmid:25995053 + + p(MGI:Dapk1) association p(MGI:Mapt) + + + + + + + pmid:25995053 + + p(MGI:Dapk1) directlyIncreases complex(p(MGI:Dapk1), p(MGI:Mapt)) + + + + + + + pmid:25995053 + + p(MGI:Dapk1) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) + + + + + + + + + + + pmid:25995053 + + complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") + + + + + + + pmid:25995053 + + p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") + + + + + + + pmid:25125464 + + p(MGI:Mapt, pmod(Ph, Ser, 262)) positiveCorrelation p(MGI:Crh) + + + + + + + pmid:24853415 + + p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) + + + + + + + pmid:24853415 + + p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ph, Ser, 71)) negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:28137862 + + p(MGI:Dcaf1) association p(MGI:Dyrk1a) + + + + + + + pmid:28137862 + + p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pmid:28137862 + + p(MGI:Dcaf1) association p(MGI:Hap1) + + + + + + + pmid:28137862 + + p(MGI:Dyrk1a) association p(MGI:Dcaf1) + + + + + + + pmid:28137862 + + p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pmid:28137862 + + p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + + + + + + + pmid:29221819 + + p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) + + + + + + + pmid:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) + + + + + + + pmid:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) + + + + + + + pmid:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) + + + + + + + pmid:28775333 + + p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") + + + + + + + pmid:28775333 + + p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") + + + + + + + pmid:28775333 + + p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) + + + + + + + pmid:28775333 + + p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) + + + + + + + + + + + pmid:28137862 + + complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) + + + + + + + pmid:28137862 + + p(MGI:Hap1) association p(MGI:Dcaf1) + + + + + + + pmid:28137862 + + p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:28137862 + + p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pmid:29221819 + + a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:29221819 + + a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:29221819 + + a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:29221819 + + bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:29221819 + + act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pmid:28884684 + + a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin)) + + + + + + + pmid:28884684 + + a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:28884684 + + a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin)) + + + + + + + pmid:28884684 + + a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") + + + + + + + pmid:28884684 + + act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") + + + + + + + pmid:28250274 + + p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) + + + + + + + pmid:28632203 + + p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pmid:28167836 + + act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites) + + + + + + + pmid:28167836 + + act(p(HGNC:DYRK1A)) regulates a(GO:axon) + + + + + + + pmid:28250274 + + a(CHEBI:harmine) decreases p(HGNC:DYRK1A) + + + + + + + pmid:28250274 + + a(CHEBI:harmine) increases p(HGNC:MME) + + + + + + + pmid:29077046 + + a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) + + + + + + + pmid:28775333 + + p(MGI:Mef2d) increases r(MGI:Dyrk1a) + + + + + + + pmid:28775333 + + p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) + + + + + + + + + + + + + pmid:28632203 + + composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pmid:28167836 + + p(HBP:"NP_001387.2:p.Arg205del") decreases act(p(HGNC:DYRK1A)) + + + + + + + pmid:28167836 + + p(HBP:"NP_001387.2:p.Arg205del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") + + + + + + + pmid:28167836 + + p(HBP:"NP_001387.2:p.Glu239del") decreases act(p(HGNC:DYRK1A)) + + + + + + + pmid:28167836 + + p(HBP:"NP_001387.2:p.Glu239del") positiveCorrelation path(MESH:"Autism Spectrum Disorder") + + + + + + + + + + + pmid:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 301)) + + + + + + + + + pmid:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + + + + + + + pmid:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + + + + + + + pmid:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt) + + + + + + + pmid:25331948 + + p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta") + + + + + + + pmid:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + + + + + + + pmid:28877763 + + p(MGI:Mapt, pmod(Ph, Ser, 301)) positiveCorrelation p(MGI:Syk) + + + + + + + pmid:28877763 + + p(MGI:Syk, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pmid:28877763 + + p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") + + + + + + + pmid:28877763 + + p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pmid:28877763 + + p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + + + + + + + pmid:18070606 + + p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18)) + + + + + + + pmid:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") + + + + + + + pmid:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") association a(HBP:"GVD bodies") + + + + + + + pmid:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) + + + + + + + pmid:26501932 + + a(HBP:"GVD bodies") association a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") + + + + + + + pmid:25331948 + + a(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:25331948 + + a(HBP:"BAY61-3606") directlyDecreases act(p(HGNC:SYK)) + + + + + + + pmid:28176663 + + a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) + + + + + + + pmid:28176663 + + a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + + + + + + + pmid:28176663 + + a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + + + + + + + pmid:28176663 + + a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:25987199 + + act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:25987199 + + act(a(HBP:"advanced glycation end product")) negativeCorrelation act(p(MGI:Glp1r)) + + + + + + + pmid:26118667 + + p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) + + + + + + + pmid:26118667 + + p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) + + + + + + + pmid:26118667 + + p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:26118667 + + p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:27087442 + + p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8") + + + + + + + pmid:14642273 + + p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin)) + + + + + + + pmid:14642273 + + p(HBP:"CDK5R1 p25") increases p(HBP:"Tau aggregates") + + + + + + + pmid:26118667 + + p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25") + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202)) + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205)) + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231)) + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422)) + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25") + + + + + + + pmid:26118667 + + a(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:App) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Bace1) + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation a(CHEBI:"amyloid-beta") + + + + + + + pmid:26118667 + + m(MIRBASE:"rno-mir-195") negativeCorrelation p(RGD:Cdk5r1) + + + + + + + + + + + pmid:26118667 + + complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1) + + + + + + + + + + + pmid:26118667 + + complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") + + + + + + + pmid:26118667 + + p(RGD:App) negativeCorrelation m(MIRBASE:"rno-mir-195") + + + + + + + pmid:26118667 + + p(RGD:Bace1) negativeCorrelation m(MIRBASE:"rno-mir-195") + + + + + + + pmid:26118667 + + p(INTERPRO:"Peptidase C2, calpain, catalytic domain") positiveCorrelation act(p(RGD:Cdk5r1)) + + + + + + + pmid:26118667 + + act(p(RGD:Cdk5r1)) positiveCorrelation p(INTERPRO:"Peptidase C2, calpain, catalytic domain") + + + + + + + pmid:26118667 + + p(RGD:Cdk5r1) negativeCorrelation m(MIRBASE:"rno-mir-195") + + + + + + + pmid:27087442 + + path(MESH:Cognition) negativeCorrelation p(MGI:Cdk5) + + + + + + + pmid:25987199 + + act(p(MGI:Glp1r)) increases act(p(MGI:Ppargc1a)) + + + + + + + pmid:25987199 + + act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin)) + + + + + + + pmid:25987199 + + act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:25987199 + + act(p(MGI:Glp1r)) negativeCorrelation act(a(HBP:"advanced glycation end product")) + + + + + + + pmid:25143394 + + p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) + + + + + + + pmid:25143394 + + p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) + + + + + + + pmid:25143394 + + p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) + + + + + + + pmid:23134599 + + p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(RGD:Ppp2ca) + + + + + + + pmid:25125464 + + p(MGI:Crhr1) positiveCorrelation p(HBP:"Tau epitope, AT8") + + + + + + + pmid:25125464 + + p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau epitope, PHF1") + + + + + + + pmid:25125464 + + p(MGI:Crhr1) positiveCorrelation p(MGI:Mapk8) + + + + + + + pmid:25125464 + + p(MGI:Crhr1) positiveCorrelation a(HBP:"Tau aggregates") + + + + + + + pmid:25125464 + + p(MGI:Mapt, pmod(Ph, Ser, 422)) positiveCorrelation p(MGI:Crh) + + + + + + + pmid:25125464 + + p(MGI:Mapk8) positiveCorrelation p(MGI:Crhr1) + + + + + + + pmid:25125464 + + a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) + + + + + + + pmid:19459590 + + p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:19459590 + + p(HBP:"Tau epitope, CP13") decreases act(p(HGNC:MAPT)) + + + + + + + pmid:23294633 + + a(HBP:"Tau epitope, AT100") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf a(HBP:"Tau epitope, AT100") + + + + + + + pmid:22833681 + + p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf a(HBP:"Tau epitope, AT100") + + + + + + + + + + + pmid:22833681 + + a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169")) + + + + + + + pmid:22833681 + + act(p(ECCODE:"3.2.1.169")) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + + + + + + + pmid:23294633 + + p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:23294633 + + p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin)) + + + + + + + pmid:23294633 + + p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:23294633 + + p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin)) + + + + + + + pmid:22002427 + + p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + + + + + + + pmid:22002427 + + p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pmid:24033439 + + p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pmid:24033439 + + p(HBP:"Tau epitope, PHF1") increases a(GO:"neurofibrillary tangle") + + + + + + + pmid:24251416 + + p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4") + + + + + + + pmid:22156579 + + act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) + + + + + + + pmid:22156579 + + p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) + + + + + + + pmid:22941973 + + act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + + + + + + + pmid:22941973 + + act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization") + + + + + + + pmid:22941973 + + act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp)) + + + + + + + pmid:22941973 + + act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel) + + + + + + + pmid:23722080 + + a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) + + + + + + + pmid:23722080 + + a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + + + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") + + + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25") + + + + + + + pmid:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") + + + + + + + + + + + + + pmid:23722080 + + composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + + + + + + + pmid:23722080 + + composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(Ph, Ser, 404)) + + + + + + + pmid:23722080 + + composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") + + + + + + + pmid:22952452 + + p(HGNC:TRAK1) positiveCorrelation act(a(GO:mitochondrion)) + + + + + + + pmid:22952452 + + p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22952452 + + p(HGNC:TRAK1) negativeCorrelation p(HGNC:MARK1) + + + + + + + pmid:22952452 + + p(HGNC:RHOT1) positiveCorrelation act(a(GO:mitochondrion)) + + + + + + + pmid:22952452 + + p(HGNC:RHOT1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22952452 + + p(HGNC:RHOT1) negativeCorrelation p(HGNC:MARK1) + + + + + + + pmid:23001711 + + p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + + + + + + + pmid:22072628 + + p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + + + pmid:22072628 + + p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + pmid:8226987 + + p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT)) + + + + + + + pmid:24401760 + + p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pmid:24401760 + + p(HGNC:ITPKB) partOf a(HBP:"dystrophic neurite") + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases bp(GO:"apoptotic process") + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases p(MGI:Bace1) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Bace1)) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Map2k1)) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Map2k2)) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases a(HBP:Astrogliosis) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) + + + + + + + pmid:24401760 + + p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:24401760 + + a(HBP:"SL-327") directlyDecreases p(MGI:Map2k1) + + + + + + + pmid:24401760 + + a(HBP:"SL-327") directlyDecreases p(MGI:Map2k2) + + + + + + + pmid:24401760 + + a(HBP:"SL-327") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:23737518 + + a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193594") decreases a(HBP:"Tau epitope, PHF1") + + + + + + + pmid:23737518 + + a(HBP:"LDN-193594") decreases act(p(HBP:"CDK5R1 p25")) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193594") directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193594") isA a(HBP:diaminothiazole) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193665") isA a(HBP:diaminothiazole) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pmid:23737518 + + a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pmid:23737518 + + a(HBP:"LDN-213843") isA a(HBP:diaminothiazole) + + + + + + + pmid:23737518 + + a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pmid:23737518 + + a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pmid:7667312 + + p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments") + + + + + + + pmid:7667312 + + a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments") + + + + + + + pmid:25672970 + + a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B)) + + + + + + + pmid:25672970 + + a(HBP:"C-30-27") increases path(MESH:Cognition) + + + + + + + pmid:25672970 + + act(p(HGNC:KAT2B)) positiveCorrelation p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) + + + + + + + pmid:25546293 + + p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + + + + + + + pmid:24686445 + + act(p(HGNC:KAT2B)) positiveCorrelation act(p(FPLX:ERK)) + + + + + + + pmid:24686445 + + act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) + + + + + + + pmid:25672970 + + p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) positiveCorrelation act(p(HGNC:KAT2B)) + + + + + + + + + pmid:24844691 + + a(HBP:"Tubastatin A") directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:24844691 + + a(HBP:"Tubastatin A") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:24844691 + + a(HBP:"Tubastatin A") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:24844691 + + a(HBP:"ACY-1215") directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:24844691 + + a(HBP:"ACY-1215") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1)) + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1)) + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1)) + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub)) + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane)) + + + + + + + pmid:25546293 + + p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) negativeCorrelation act(p(HGNC:HDAC6)) + + + + + + + pmid:25546293 + + a(CHEBI:vorinostat) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:25546293 + + a(CHEBI:vorinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + + + + + + + pmid:25546293 + + a(HBP:crebinostat) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:25546293 + + a(HBP:crebinostat) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + + + + + + + pmid:27917100 + + a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pmid:26890116 + + a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pmid:18558669 + + a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:29540553 + + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174)) + + + + + + + pmid:29540553 + + p(MGI:Sirt1) positiveCorrelation a(GO:"neuron to neuron synapse") + + + + + + + pmid:29540553 + + p(MGI:Sirt1) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pmid:29540553 + + a(GO:"neuron to neuron synapse") positiveCorrelation p(MGI:Sirt1) + + + + + + + pmid:29540553 + + p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713")) + + + + + + + pmid:29540553 + + p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:29540553 + + p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:29540553 + + p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:27550730 + + a(HBP:"CM-414") directlyDecreases act(p(MGI:Pde5a)) + + + + + + + pmid:27550730 + + a(HBP:"CM-414") directlyDecreases act(p(ECCODE:"3.5.1.98")) + + + + + + + pmid:27550730 + + a(HBP:"CM-414") decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:27550730 + + a(HBP:"CM-414") decreases p(MGI:Mapt, pmod(Ph)) + + + + + + + pmid:27550730 + + a(HBP:"CM-414") decreases act(p(MGI:Gsk3b), ma(kin)) + + + + + + + pmid:27550730 + + act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) + + + + + + + pmid:29559585 + + p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300)) + + + + + + + pmid:29559585 + + p(MGI:Gapdh, pmod(NO)) positiveCorrelation p(MGI:Mapt, pmod(Ac, Lys, 280)) + + + + + + + + + pmid:29559585 + + act(p(MGI:Ep300)) positiveCorrelation p(MGI:Sirt1, pmod(NO)) + + + + + + + pmid:29559585 + + p(MGI:Sirt1, pmod(NO)) positiveCorrelation act(p(MGI:Ep300)) + + + + + + + pmid:29559585 + + p(MGI:Sirt1, pmod(NO)) increases act(p(MGI:Sirt1)) + + + + + + + pmid:29559585 + + p(MGI:Mapt, pmod(Ac, Lys, 280)) positiveCorrelation p(MGI:Gapdh, pmod(NO)) + + + + + + + pmid:29559585 + + a(HBP:CGP3466B) decreases p(MGI:Gapdh, pmod(NO)) + + + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 163)) + + + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 280)) + + + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 281)) + + + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) association p(HGNC:MAPT, pmod(Ac, Lys, 369)) + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) decreases act(p(HGNC:MAPT)) + + + + + + + pmid:28855586 + + composite(p(HGNC:MAPT, pmod(Ac, Lys, 163)), p(HGNC:MAPT, pmod(Ac, Lys, 280)), p(HGNC:MAPT, pmod(Ac, Lys, 281)), p(HGNC:MAPT, pmod(Ac, Lys, 369))) negativeCorrelation act(a(CHEBI:"amyloid-beta")) + + + + + + + pmid:28287136 + + p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates") + + + + + + + pmid:28002468 + + p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif") + + + + + + + + + + + pmid:28002468 + + p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif") + + + + + + + pmid:28002468 + + p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif") + + + + + + + pmid:28002468 + + a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:28002468 + + a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) + + + + + + + pmid:27041503 + + p(HGNC:WWC1) negativeCorrelation bp(MESH:"Long-Term Potentiation") + + + + + + + pmid:26390242 + + a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) + + + + + + + pmid:26390242 + + a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + + + + + + + pmid:26390242 + + a(CHEBI:salsalate) decreases p(HGNC:MAPT) + + + + + + + pmid:26390242 + + a(CHEBI:salsalate) positiveCorrelation a(MESH:Hippocampus) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf a(HBP:"microtubule-binding region") + + + + + + + pmid:26192747 + + p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:24686445 + + a(HBP:"peripheral nervous system injury") increases p(HGNC:NGF) + + + + + + + pmid:24686445 + + p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAP43) + + + + + + + pmid:24686445 + + p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:GAL) + + + + + + + pmid:24686445 + + p(HBP:"Histone H3", pmod(Ac, Lys, 9)) increases r(HGNC:BDNF) + + + + + + + + + + + pmid:23487739 + + a(HBP:Tubacin) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:21427723 + + a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pmid:21427723 + + a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:20869593 + + a(HBP:C646) directlyDecreases act(p(HGNC:EP300)) + + + + + + + pmid:20869593 + + a(HBP:C646) decreases p(HGNC:MAPT, pmod(Ac)) + + + + + + + pmid:29540553 + + a(HBP:"Pathological Tau Spreading") negativeCorrelation act(p(HGNC:SIRT1)) + + + + + + + pmid:29226865 + + p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) + + + + + + + pmid:28771976 + + a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) + + + + + + + pmid:28771976 + + a(HBP:RGFP966) association bp(GO:memory) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) increases bp(GO:learning) + + + + + + + pmid:29844403 + + a(HBP:MPT0G211) increases bp(GO:memory) + + + + + + + pmid:19732809 + + a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:19732809 + + a(HBP:"O-GlcNAcylation") negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pmid:19732809 + + a(HBP:"O-GlcNAcylation") association bp(MESH:"Hot Temperature") + + + + + + + pmid:19732809 + + a(HBP:"O-GlcNAcylation") negativeCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pmid:19732809 + + g(HGNC:OGT) positiveCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pmid:26041011 + + a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") association p(HGNC:STUB1) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) + + + + + + + pmid:27325702 + + p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") + + + + + + + pmid:27325702 + + p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") + + + + + + + pmid:27325702 + + p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) + + + + + + + pmid:27325702 + + p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") + + + + + + + + + + + + + + + pmid:27325702 + + complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex") + + + + + + + + + + + + + + + + + + + + + pmid:25378699 + + p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:25378699 + + p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub)) + + + + + + + pmid:16464864 + + p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + + + + + + + pmid:24905733 + + p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub)) + + + + + + + pmid:8391280 + + p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") + + + + + + + pmid:8391280 + + p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") + + + + + + + pmid:27260838 + + p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") + + + + + + + pmid:27260838 + + p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain") + + + + + + + pmid:27260838 + + p(HBP:pretangles) positiveCorrelation p(HBP:"phosphatase-activating domain") + + + + + + + pmid:27601475 + + a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers") + + + + + + + pmid:27601475 + + a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide") + + + + + + + pmid:27601475 + + act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide") + + + + + + + pmid:27373205 + + p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + + + + + + + pmid:11606569 + + g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pmid:27716675 + + a(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pmid:27716675 + + a(HBP:neuroinflammation) positiveCorrelation g(DBSNP:rs63751438) + + + + + + + pmid:27716675 + + a(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers") + + + + + + + pmid:27716675 + + g(DBSNP:rs63751438) positiveCorrelation a(HBP:neuroinflammation) + + + + + + + pmid:19765634 + + g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:19765634 + + g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") + + + + + + + pmid:19765634 + + g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") + + + + + + + pmid:21843595 + + p(MGI:Sumo3) negativeCorrelation bp(GO:learning) + + + + + + + pmid:21843595 + + p(MGI:Sumo3) negativeCorrelation bp(GO:memory) + + + + + + + pmid:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Irf1) + + + + + + + pmid:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Tnf) + + + + + + + pmid:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Il6) + + + + + + + pmid:19782030 + + p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo)) + + + + + + + pmid:19782030 + + p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1)) + + + + + + + + + pmid:19782030 + + p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo)) + + + + + + + pmid:19782030 + + p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1)) + + + + + + + + + + + + + pmid:19323834 + + complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) + + + + + + + pmid:19323834 + + p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + + + + + + + pmid:19323834 + + p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) + + + + + + + pmid:18675254 + + p(HGNC:UBE2I) partOf complex(GO:"endoplasmic reticulum") + + + + + + + pmid:19323834 + + p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) + + + + + + + pmid:18675254 + + p(HGNC:APP, pmod(Sumo, Lys, 587)) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:18675254 + + p(HGNC:APP, pmod(Sumo, Lys, 595)) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:18675254 + + p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) + + + + + + + pmid:18675254 + + p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) + + + + + + + pmid:17346237 + + p(HGNC:SUMO3) increases p(HGNC:BACE1) + + + + + + + pmid:17346237 + + p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_711")) + + + + + + + pmid:17346237 + + p(HGNC:SUMO3) increases p(HGNC:APP, frag("672_713")) + + + + + + + pmid:16464864 + + a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + + + + + + + pmid:12506199 + + p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta") + + + + + + + pmid:12506199 + + p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") + + + + + + + pmid:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + + + + + + + pmid:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + + + + + + + pmid:29334120 + + p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) + + + + + + + pmid:29334120 + + p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) + + + + + + + pmid:26142647 + + p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) + + + + + + + pmid:29421605 + + p(RGD:Ptpn1) negativeCorrelation p(RGD:Irs1, pmod(Ph)) + + + + + + + pmid:29421605 + + p(RGD:Ptpn1) negativeCorrelation p(RGD:Akt1, pmod(Ph)) + + + + + + + pmid:29421605 + + p(RGD:Ptpn1) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) + + + + + + + pmid:29421605 + + p(RGD:Ptpn1) negativeCorrelation p(RGD:Mtor, pmod(Ph)) + + + + + + + pmid:29421605 + + p(RGD:Ptpn1) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) + + + + + + + pmid:29421605 + + p(RGD:Irs1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + + + + + + + + + pmid:29421605 + + p(RGD:Akt1, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + + + + + + + + + pmid:29421605 + + p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + + + + + + + pmid:29421605 + + p(RGD:Mtor, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + + + + + + + + + pmid:29421605 + + p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation p(RGD:Ptpn1) + + + + + + + + + pmid:29062069 + + p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) + + + + + + + pmid:28422052 + + a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + + + + + + + pmid:28422052 + + a(CHEBI:"folic acid") increases p(MGI:Dnmt1) + + + + + + + pmid:28422052 + + p(MGI:Dnmt1) increases p(MGI:Ppp2ca, pmod(Me, Leu, 309)) + + + + + + + pmid:28422052 + + p(MGI:Ppp2ca, pmod(Me, Leu, 309)) decreases act(p(MGI:Ppp2ca)) + + + + + + + pmid:25143394 + + p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:25143394 + + p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:23134599 + + a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) + + + + + + + pmid:23134599 + + a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) + + + + + + + pmid:23134599 + + a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) + + + + + + + pmid:23134599 + + p(RGD:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + + + + + + + pmid:21489990 + + act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + + + + + + + pmid:21489990 + + p(RGD:Egr1) directlyIncreases act(p(RGD:Cdk5)) + + + + + + + pmid:19623258 + + act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT8") + + + + + + + pmid:19623258 + + act(complex(GO:"NMDA selective glutamate receptor complex")) positiveCorrelation p(HBP:"Tau epitope, AT180") + + + + + + + pmid:19623258 + + p(HBP:"Tau epitope, AT180") positiveCorrelation act(complex(GO:"NMDA selective glutamate receptor complex")) + + + + + + + pmid:19623258 + + p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) + + + + + + + pmid:25001178 + + act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin)) + + + + + + + pmid:24964035 + + p(HGNC:SMAD2) decreases p(HGNC:PIN1) + + + + + + + + + + + pmid:24964035 + + p(HGNC:SMAD3) decreases p(HGNC:PIN1) + + + + + + + pmid:23832849 + + act(p(INTERPRO:"FKBP-type peptidyl-prolyl cis-trans isomerase domain")) directlyDecreases p(HBP:"tubulin-binding repeat 3") + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ph, Ser, 16)) negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases act(p(HGNC:PIN1)) + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ph, Ser, 65)) negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ph, Ser, 65)) increases act(p(HGNC:PIN1)) + + + + + + + pmid:22926167 + + p(HGNC:PIN1, pmod(Ac, Lys, 46)) negativeCorrelation p(HGNC:MAPT) + + + + + + + pmid:19401603 + + complex(GO:"tubulin complex") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + + + + + + + pmid:28019679 + + bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:28019679 + + complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) + + + + + + + + + pmid:27314526 + + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) + + + + + + + pmid:28019679 + + complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") + + + + + + + pmid:28019679 + + complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") + + + + + + + + + + + pmid:24561250 + + complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") + + + + + + + pmid:24561250 + + complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") + + + + + + + pmid:28019679 + + a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + + + + + pmid:28019679 + + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + + + + + pmid:28019679 + + composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) + + + + + + + pmid:28019679 + + act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pmid:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) + + + + + + + pmid:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) + + + + + + + pmid:23702978 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) + + + + + + + + + pmid:24561250 + + complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) + + + + + + + pmid:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) + + + + + + + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + complex(GO:"inflammasome complex") regulates p(HGNC:IL18) + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + + + + + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:24561250 + + act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + + + + + + + pmid:27314526 + + act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + + + + + + + + + + + + + + + + + + + + + + + + + pmid:23702978 + + complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) + + + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) + + + + + + + pmid:27314526 + + complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") + + + + + + + pmid:23702978 + + p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) + + + + + + + pmid:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pmid:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") + + + + + + + + + pmid:23702978 + + complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + bp(GO:"cell activation") increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + p(HGNC:NLRP1) increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + p(HGNC:NLRP1) increases p(HGNC:IL1B) + + + + + + + + + + + pmid:27314526 + + p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") + + + + + + + pmid:27314526 + + act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") + + + + + + + pmid:23702978 + + p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") + + + + + + + pmid:23702978 + + p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") + + + + + + + pmid:23702978 + + act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) + + + + + + + + + pmid:24561250 + + p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:23702978 + + complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pmid:24561250 + + complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) + + + + + + + pmid:24561250 + + act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) + + + + + + + pmid:24561250 + + complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") + + + + + + + + + + + pmid:23702978 + + composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + + + + + pmid:23702978 + + composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) + + + + + + + pmid:23702978 + + act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) + + + + + + + pmid:23702978 + + a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) + + + + + + + pmid:27314526 + + a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:23702978 + + act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") + + + + + + + pmid:23702978 + + a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) + + + + + + + pmid:23702978 + + act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") + + + + + + + pmid:23702978 + + a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) + + + + + + + + + + + pmid:23702978 + + complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) + + + + + + + + + + + pmid:23702978 + + complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) + + + + + + + + + + + pmid:23702978 + + act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") + + + + + + + pmid:24561250 + + p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pmid:23702978 + + p(HGNC:SCAF11) increases bp(GO:pyroptosis) + + + + + + + pmid:23702978 + + act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) + + + + + + + pmid:23702978 + + a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + + + + + + + pmid:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I")) + + + + + + + pmid:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) + + + + + + + pmid:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) + + + + + + + pmid:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) + + + + + + + pmid:23702978 + + a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18)) + + + + + + + pmid:23702978 + + act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) + + + + + + + pmid:23702978 + + p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) + + + + + + + + + + + pmid:23702978 + + p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + p(HGNC:CASP8) increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) + + + + + + + pmid:23702978 + + act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) + + + + + + + + + + + pmid:23702978 + + complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) + + + + + + + + + + + + + pmid:23702978 + + complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) + + + + + + + + + + + + + pmid:23702978 + + complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) + + + + + + + pmid:23702978 + + p(HGNC:XIAP) decreases complex(GO:ripoptosome) + + + + + + + pmid:23702978 + + p(HGNC:BIRC3) decreases complex(GO:ripoptosome) + + + + + + + pmid:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) + + + + + + + pmid:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) + + + + + + + pmid:23702978 + + p(FPLX:TNFRSF) increases p(HGNC:NLRP3) + + + + + + + pmid:23702978 + + p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub)) + + + + + + + pmid:23702978 + + p(FPLX:IFNB) increases p(HGNC:AIM2) + + + + + + + pmid:23702978 + + g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") + + + + + + + + + pmid:24561250 + + g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta") + + + + + + + pmid:24561250 + + g(HGNC:NLRP3) decreases bp(GO:memory) + + + + + + + pmid:24561250 + + g(HGNC:NLRP3) decreases bp(GO:behavior) + + + + + + + pmid:23702978 + + path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) + + + + + + + pmid:23702978 + + bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:23702978 + + bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:23702978 + + p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3)) + + + + + + + pmid:23702978 + + a(MESH:Interferons) increases p(HGNC:AIM2) + + + + + + + pmid:23702978 + + a(MESH:Interferons) decreases p(HGNC:IL1B) + + + + + + + pmid:23702978 + + a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:23702978 + + m(HGNC:MIR223) decreases p(HGNC:NLRP3) + + + + + + + pmid:23702978 + + act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) + + + + + + + pmid:23702978 + + p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") + + + + + + + pmid:23702978 + + p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) + + + + + + + pmid:23702978 + + act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pmid:23702978 + + p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) + + + + + + + pmid:23702978 + + p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1)) + + + + + + + + + + + pmid:23702978 + + complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) + + + + + + + + + pmid:23702978 + + complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) + + + + + + + + + pmid:23702978 + + p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) + + + + + + + pmid:23702978 + + p(HGNC:CARD17) decreases p(HGNC:IL1B) + + + + + + + pmid:23702978 + + p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + + + + + + + + + + + pmid:23702978 + + p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + + + + + + + pmid:23702978 + + p(MGI:Mefv) decreases sec(p(MGI:Il1b)) + + + + + + + + + + + pmid:23702978 + + composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) + + + + + + + pmid:24561250 + + path(MESH:Stroke) increases complex(GO:"inflammasome complex") + + + + + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") + + + + + + + pmid:24561250 + + p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") + + + + + + + pmid:24561250 + + p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pmid:24561250 + + p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pmid:24561250 + + p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pmid:24561250 + + a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") + + + + + + + pmid:24561250 + + a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + a(MESH:Alarmins) increases complex(GO:"inflammasome complex") + + + + + + + pmid:24561250 + + a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) + + + + + + + + + + + pmid:24561250 + + complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") + + + + + + + + + + + + + pmid:24561250 + + complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + + + + + + + pmid:24561250 + + complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:24561250 + + a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:24561250 + + path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:24561250 + + path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18)) + + + + + + + pmid:24561250 + + path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B)) + + + + + + + pmid:24561250 + + path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) + + + + + + + pmid:24561250 + + p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:24561250 + + p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:27314526 + + act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") + + + + + + + pmid:27314526 + + act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") + + + + + + + pmid:27314526 + + act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") + + + + + + + pmid:27314526 + + p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pmid:27314526 + + p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pmid:24561250 + + p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:24561250 + + p(MGI:P2rx4) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + p(MGI:P2rx4) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) + + + + + + + pmid:24561250 + + p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + + + + + + + + + pmid:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + p(HGNC:PANX1) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + p(HGNC:PANX1) increases p(HGNC:IL18) + + + + + + + pmid:24561250 + + a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") + + + + + + + pmid:24561250 + + a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pmid:24561250 + + p(MGI:Nlrp3) increases p(MGI:Il1b) + + + + + + + pmid:24561250 + + p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") + + + + + + + pmid:24561250 + + p(MGI:Nlrp3) increases a(MESH:Neuropathology) + + + + + + + pmid:24561250 + + p(MGI:Nlrp3) decreases bp(GO:cognition) + + + + + + + + + + + pmid:24561250 + + composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) + + + + + + + + + + + pmid:24561250 + + composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:PANX1) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:IL1B) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:IL18) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pmid:24561250 + + a(CHEBI:probenecid) increases bp(GO:learning) + + + + + + + pmid:24561250 + + a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) + + + + + + + pmid:24561250 + + a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pmid:24561250 + + p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") + + + + + + + pmid:24561250 + + p(MGI:Casp1) increases a(MESH:Neuropathology) + + + + + + + pmid:24561250 + + p(MGI:Casp1) decreases bp(GO:cognition) + + + + + + + pmid:27314526 + + bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") + + + + + + + pmid:27314526 + + act(p(HGNC:PRSS3)) increases p(HGNC:IL18) + + + + + + + pmid:27314526 + + act(p(FPLX:ELA)) increases p(HGNC:IL18) + + + + + + + pmid:27314526 + + act(p(HGNC:CTSG)) increases p(HGNC:IL18) + + + + + + + + + + + pmid:27314526 + + composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + + + pmid:27314526 + + path(MESH:Periodontitis) decreases bp(GO:cognition) + + + +

Curation Quality

@@ -130908,7 +146165,7 @@

Namespaces

Namespace References - 20 + 18

This section lists all of the namespaces that are defined in the original BEL document. @@ -130928,13 +146185,8 @@

- CTO - https://arty.scai.fraunhofer.de/artifactory/bel/namespace/clinical-trial-ontology/clinical-trial-ontology-1.0.0.belns - - - - DO - https://arty.scai.fraunhofer.de/artifactory/bel/namespace/disease-ontology/disease-ontology-20170725.belns + DOID + https://raw.githubusercontent.com/pharmacome/terminology/c0c576e3d3ab9b25a3982251a4ee2fd7c49e1679/external/doid-names.belns @@ -130948,13 +146200,13 @@

- FPLX - https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns + FB + https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/fb-names.belns - GFAM - https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc.genefamily-names.belns + FPLX + https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns @@ -130992,11 +146244,6 @@

https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns - - MESHC - https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mesh-chemicals/mesh-chemicals-20170725.belns - - MGI https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns @@ -131004,7 +146251,7 @@

MIRBASE - https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mirbase-names.belns + https://raw.githubusercontent.com/pharmacome/terminology/0c9853baf883545b922ff1b138a9f297a70b7951/external/mirbase-names.belns @@ -131028,7 +146275,7 @@

Unused Namespaces - 1 + 2

The source BEL document contained references to the following namespaces, but they were never @@ -131038,7 +146285,11 @@

@@ -131051,7 +146302,7 @@

Namespaces with Incorrect Names - 5 + 6

+ + + + +

+ Unused Locally Defined Annotations + 9 +

+

+ The source BEL document contained the following list annotations, but no references to the + following values. It is suggested to prune these values from the list definitions. +

+

+ Note: this may be due to errors occurring in all statements with these + annotations. +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
AnnotationValues
HasQuantitativeInformation +
    + +
  • + False +
    • + +
+
Km_ATP +
    + +
  • + 10 μM +
    • + +
+
MeasurementType +
    + +
  • + CSF concentration +
    • + +
  • + plasma concentration +
    • + +
  • + brain concertration +
    • + +
+
MeasurementValue +
    + +
  • + 1.4 +
    • + +
  • + 1.3 +
    • + +
+
Method +
    + +
  • + Microtubule polymerization Assay +
    • + +
+
PublicationType +
    + +
  • + Research +
    • + +
  • + Comment +
    • + +
+
Research_Model +
    + +
  • + K3 model with hyperphoshorylated tau resembling FTD +
    • + +
+
Tau_Epitope +
    + +
  • + AT270 +
    • + +
  • + AD2 +
    • + +
  • + AP422 +
    • + +
+
Vmax +
    + +
  • + 656 nM/min/mg +
    • + +
  • + 59 μM +
    • + +
+
+ + + +
+

Warnings

+
+ -

- Unused Locally Defined Annotations - 10 +

Warning Statistics

+
+
+
+ + + +

+ Most Frequent 20 Errors

-

- The source BEL document contained the following list annotations, but no references to the - following values. It is suggested to prune these values from the list definitions. -

-

- Note: this may be due to errors occurring in all statements with these - annotations. -

- - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
AnnotationValuesErrorFrequency
"pro-nerve growth factor, human" is not in the MESH namespace7
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace6
"latrepirdine" is not in the MESH namespace5
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace5
"Nitrosative Stress" is not in the MESH namespace4
"neuroinflammatory response" is not in the GO namespace4
"gambogic amide" is not in the MESH namespace3
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace3
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace2
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace2
"Tau antibody, CP13" is not in the HBP namespace2
"soluble tau" is not in the HBP namespace2
"3-3' dityrosine cross-linking" is not in the HBP namespace2
"CA1 interneuron" is not in the HBP namespace2
+ + + + + +

All Errors + 58 +

+ + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
PathLineBELMessage
ExpGroup -
    +
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel365path(MESH:D060825) -> a(MESH:"pro-nerve growth factor, human")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel366path(MESH:D000544) -> a(MESH:"pro-nerve growth factor, human")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel368complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) -> bp(GO:"GO:0031175")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel385a(MESH:"pro-nerve growth factor, human") pos path(MESH:D003072)"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel398a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544)"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel414complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) -> bp(GO:"GO:0006915")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel450composite(complex(p(HGNC:NGFR), p(HGNC:SORT1)), a(MESH:"pro-nerve growth factor, human")) -> bp(GO:"GO:0006915")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel523p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(Ph)) -> act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases"))"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel544act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) -- bp(GO:"GO:0031175")"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel603complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) => p(HGNC:NTRK1, pmod(Ph))"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel609a(MESH:"gambogic amide") -| bp(HBP:Excitotoxicity)"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel610a(MESH:"gambogic amide") -> bp(GO:"GO:0031175")"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel624p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") hasMembers list(p(HGNC:CHRNA1) , p(HGNC:CHRNA2), p(HGNC:CHRNA3), p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNA6), p(HGNC:CHRNA7), p(HGNC:CHRNA9), p(HGNC:CHRNA10), p(HGNC:CHRNB1), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4), p(HGNC:CHRND), p(HGNC:CHRNG))"Cholinergic receptors nicotinic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel629p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMembers list(p(HGNC:CHRM1), p(HGNC:CHRM2), p(HGNC:CHRM3), p(HGNC:CHRM4), p(HGNC:CHRM5))"Cholinergic receptors muscarinic" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel732a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D060825)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel733a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D024801)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel734a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| a(CHEBI:"amyloid-beta polypeptide 42")"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel735a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -> act(p(MGI:Chrm1))"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel737a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| p(MGI:Bace1)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel738a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| act(p(MGI:Gsk3b))"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel758path(MESH:D000544) -| r(HGNCGENEFAMILY:"Synaptotagmins")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel762p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0031629")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel764p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0007269")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel782p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") -> p(HGNC:MAPT, pmod(Ph))"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel783act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) -| bp(HBP:hyperphosphorylation)"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel1007a(MESH:"latrepirdine") -| act(p(HGNC:BCHE))"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel1008a(MESH:"latrepirdine") -| act(p(HGNC:ACHE))"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel1010a(MESH:"latrepirdine") -| bp(GO:"GO:0098989")"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel1012a(MESH:"latrepirdine") -| bp(GO:"GO:0046902")"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/receptors/mufson2008.bel1013a(MESH:"latrepirdine") -> bp(MESH:D000066829)"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel139complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, PHF1")))"Tau antibody, PHF1" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel140complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13")))"Tau antibody, CP13" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel142p(MGI:Tfeb) cnc p(MGI:Cp13)"Cp13" is not in the MGI namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel145complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT8")))"Tau antibody, AT8" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel146complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT180")))"Tau antibody, AT180" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel147complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13")))"Tau antibody, CP13" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel151p(MGI:Tfeb) -| p(HBP:"soluble tau",pmod(Ph))"soluble tau" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel152p(MGI:Tfeb) cnc p(HBP:"soluble tau")"soluble tau" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel164complex(p(HBP:"Tau antibody,MC1"))"Tau antibody,MC1" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel106p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel107p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel108p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel109p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel129p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel610a(CHEBI:"amyloid-beta") -> bp(MESH:"Nitrosative Stress")"Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel611bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164))"Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel612bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208))"Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel852a(CHEBI:peroxynitrite) -> bp(MESH:"Nitrosative Stress")"Nitrosative Stress" is not in the MESH namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel920a(CHEBI:peroxynitrite) -> a(HBP:"3-3' dityrosine cross-linking")"3-3' dityrosine cross-linking" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel921a(HBP:"3-3' dityrosine cross-linking") pos a(HBP:"paired helical filaments")"3-3' dityrosine cross-linking" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1488p(MGI:Ttbk1) -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1862act(p(MGI:Dapk1)) neg tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron"))"CA1 interneuron" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1863tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) pos bp(GO:memory)"CA1 interneuron" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2478act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) pos a(HBP:"long-term depression")"long-term depression" is not in the HBP namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2946a(CHEBI:lipopolysaccharide) -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2947a(CHEBI:"amyloid-beta") -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2948a(HBP:"C-30-27") -| bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
/Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel3396a(HBP:MPT0G211) -> p(HBP:"Blood-Brain Barrier")"Blood-Brain Barrier" is not in the HBP namespace
+ +
+ +

Biogrammar

+
+ +

+ Regulatory Pairs + 27 +

+

+ These pairs of nodes represent motifs like A increases B and + B decreases A. +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
Node ANode B
p(HGNC:PIN1)p(HGNC:SMAD2)
a(MESH:Neurons)p(HGNC:MAPT)
p(HGNC:MAPT)bp(HP:Neurodegeneration)
a(GO:synapse)p(HGNC:MAPT)
p(HGNC:TNF)a(CHEBI:nicotine)
p(HGNC:RELA)bp(GO:"long-term synaptic potentiation")
bp(GO:"late endosomal microautophagy")p(MGI:Mapt)
p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")
complex(GO:"proteasome complex")a(CHEBI:"amyloid-beta")
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)
bp(GO:"calcium ion homeostasis")complex(GO:"NF-kappaB complex")
complex(GO:"NF-kappaB complex")a(CHEBI:"amyloid-beta")
p(HGNC:CHRNA7)a(CHEBI:anandamide)
a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
p(HGNC:NFKB1)bp(GO:"long-term synaptic potentiation")
a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:AK1)
bp(GO:autophagy)p(HGNC:MAPT)
a(CHEBI:"amyloid-beta")a(MESH:Microglia)
p(HGNC:CHRNA7)complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
path(MESH:Tauopathies)p(MGI:Tfeb)
complex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)
a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
bp(GO:autophagy)p(HGNC:SNCA)
bp(GO:autophagy)p(HGNC:HTT, var("?"))
bp(GO:"membrane depolarization")complex(GO:"NF-kappaB complex")
p(MGI:Mapt, var("p.Pro301Leu"))bp(GO:macroautophagy)
a(CHEBI:"amyloid-beta")p(HGNC:APOE)
+ + + +

+ Contradictory Pairs + 158 +

+

+ These pairs of nodes have a contradiction in their causal relationships, meaning they + have more than one of INCREASES, DECREASES, or CAUSES NO + CHANGE. This may be due to different experimental conditions, so these statements + need to be carefully considered in analyses. +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + -
  • - healthy controls -
    • + + + + + - - - - - - - + + + + -
  • - False -
    • + + + + + - - - - - - - + + + + -
  • - 10 μM -
    • + + + + + - - - - - - - + + + + -
  • - CSF concentration -
    • + + + + + -
  • - brain concertration -
    • + + + + + -
  • - plasma concentration -
    • + + + + + - - - - - - - + + + + -
  • - 1.4 -
    • + + + + + -
  • - 1.3 -
    • + + + + + - - - - - - - + + + + -
  • - Microtubule polymerization Assay -
    • + + + + + - - - - - - - + + + + -
  • - Comment -
    • + + + + + -
  • - Research -
    • + + + + + - - - - - - - + + + + -
  • - K3 model with hyperphoshorylated tau resembling FTD -
    • + + + + + - - - - - - - + + + + -
  • - AT270 -
    • + + + + + -
  • - AD2 -
    • + + + + + -
  • - AP422 -
    • + + + + + - - - - - - - + + + + -
  • - 59 μM -
    • + + + + + -
  • - 656 nM/min/mg -
    • + + + + + - - - - - -
    SourceRelationsTarget
    a(CHEBI:"Evans blue")increases, causesNoChangea(PUBCHEM:9832404)
    p(MGI:Chrna7)increases, decreasesa(CHEBI:"amyloid-beta")
    composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)))increases, decreasespath(MESH:Smell)
    p(HGNC:MAPT)causesNoChange, increases, association, regulatesbp(GO:"axonal transport")
    a(CHEBI:"amyloid-beta")increases, decreasesbp(GO:memory)
    complex(a(GO:"proteasome complex"), p(HGNC:USP14))increases, decreasesbp(GO:"protein catabolic process")
    a(PUBCHEM:675434)increases, causesNoChangep(FPLX:Proteasome)
    complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA))increases, hasComponent, decreasesp(HGNC:BACE1)
    p(HGNC:ACE)increases, decreasesa(CHEBI:"amyloid-beta")
    p(HGNC:TTBK2, var("p.Tyr448*"))increases, decreasesp(HGNC:TTBK2)
    a(MESH:Nicotine)increases, decreasesp(MESH:"Receptors, GABA")
    p(MGI:Chrna7)increases, decreasespath(MESH:"Spatial Memory")
    bp(MESH:Aging)increases, decreasesp(FPLX:HSP90)
    bp(GO:"response to endoplasmic reticulum stress")increases, decreasesbp(GO:"cell death")
    path(MESH:"Alzheimer Disease")decreases, positiveCorrelation, negativeCorrelation, increases, associationp(HGNC:CHRNA7)
    a(CHEBI:Thrombin)increases, causesNoChangep(HGNC:MAPT, frag("561_685"))
    a(MESH:"SNARE Proteins")increases, causesNoChangep(HGNC:CHRNA7)
    a(CHEBI:"dimethyl fumarate")increases, causesNoChangep(HGNC:NFE2L2)
    p(HGNC:WNT3A)increases, decreasesa(CHEBI:"amyloid-beta")
    p(HGNC:ABCB1)increases, decreasesa(CHEBI:"amyloid-beta")
    a(MESH:antalarmin)increases, causesNoChangea(MESH:"Embryonic Structures")
    bp(GO:autophagy)increases, decreasesp(HGNC:APP)
    a(PUBCHEM:9832404)increases, decreasesr(HGNC:SLC17A7)
    a(CHEBI:rosiglitazone)decreases, causesNoChangea(HBP:HBP00018)
    p(HGNC:PICALM)increases, decreases, positiveCorrelationa(CHEBI:"amyloid-beta")
    a(MESH:Liver)increases, decreasesa(CHEBI:"amyloid-beta")
    p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))increases, decreasesp(HGNC:TFAP2B)
    bp(GO:autophagy)increases, decreases, associationp(HGNC:MAPT)
    bp(MESH:"Heat-Shock Response")increases, causesNoChangep(NCBIGENE:492507)
    a(CHEBI:rivastigmine)increases, decreasesp(HGNC:ACHE)
    a(CHEBI:Anatabine)decreases, causesNoChangep(MGI:Ifng)
    bp(MESH:Autophagy)increases, decreasesp(HBP:"Tau C3")
    p(HGNC:CDC37)increases, decreasesp(HGNC:MAPT)
    p(HGNC:CHRM1)increases, causesNoChangebp(GO:"ERK1 and ERK2 cascade")
    p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))decreases, causesNoChangepath(MESH:Smell)
    p(HGNC:CHRNA7)increases, decreases, regulatesa(CHEBI:"glutamate(2-)")
    p(HGNC:BCHE)decreases, directlyIncreasesa(CHEBI:acetylcholine)
    complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A))increases, decreasesbp(GO:"anterograde axonal protein transport")
    a(MESH:Neurons)increases, causesNoChangep(HGNC:MAPT)
    p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))increases, decreasescomplex(GO:"protein phosphatase type 2A complex")
    p(HGNC:TTBK2, var("p.Asp449*"))increases, decreasesp(HGNC:TTBK2)
    a(CHEBI:galanthamine)increases, decreasesp(HGNC:ACHE)
    a(MESH:Kidney)increases, decreasesa(CHEBI:"amyloid-beta")
    p(HGNC:IDE)increases, decreasesa(CHEBI:"amyloid-beta")
    a(CHEBI:"amyloid-beta polypeptide 42")decreases, causesNoChangep(ECCODE:"2.7.11.31")
    a(CHEBI:Anatabine)decreases, causesNoChangep(MGI:Tnf)
    a(CHEBI:"amyloid-beta")decreases, causesNoChangepath(HBP:Neurodegeneration)
    a(CHEBI:nicotine)decreases, causesNoChangea(CHEBI:"amyloid-beta")
    a(CHEBI:chloroquine)increases, decreasesp(HGNC:MAPT)
    a(CHEBI:"chondroitin sulfate")decreases, causesNoChangea(HBP:"Tau isoform F (441 aa)")
    a(CHEBI:rolipram)increases, decreasesp(HGNC:MAPT)
    p(HGNC:MAPT)negativeCorrelation, decreases, causesNoChangea(GO:synapse)
    p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))decreases, causesNoChangep(HGNC:SLC17A7)
    bp(MESH:Autophagy)increases, causesNoChangep(HGNC:MAPT)
    p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))decreases, causesNoChangebp(MESH:"Hand Strength")
    bp(GO:autophagy)increases, decreasespath(HBP:neurotoxicity)
    a(CHEBI:nicotine)increases, decreasesp(HBP:"alpha-4 beta-2 nAChR")
    p(FPLX:mTORC1)increases, decreasesp(HGNC:TFEB)
    p(HGNC:BACE1, frag("228_236"))increases, decreasesa(HBP:"sAPP-alpha")
    a(HBP:"amyloid-beta oligomers")increases, decreasesp(HGNC:DLG4)
    a(CHEBI:Anatabine)decreases, causesNoChangebp(HBP:Astrogliosis)
    p(HGNC:CHRNA7)decreases, positiveCorrelation, increases, association, regulatesa(CHEBI:"amyloid-beta")
    path(MESH:"Alzheimer Disease")causesNoChange, increases, association, positiveCorrelationp(HGNC:MAPT)
    p(HGNC:MAPT)increases, causesNoChangebp(GO:"anterograde axonal protein transport")
    p(HGNC:RAB5A)increases, decreasesbp(GO:endocytosis)
    a(CHEBI:"amyloid-beta")increases, decreasesa(CHEBI:acetylcholine)
    p(HGNC:TFEB)increases, decreases, regulatesa(CHEBI:"amyloid-beta")
    p(HGNC:MAPT)increases, decreases, regulatesa(MESH:Neurons)
    p(HGNC:CHAT)increases, decreases, directlyIncreasesa(CHEBI:acetylcholine)
    p(MGI:Mapt, var("p.Ala152Thr"))increases, decreasesp(MGI:Mapt)
    a(CHEBI:ambroxol)increases, decreasesp(HGNC:SNCA)
    a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")increases, decreasesbp(HP:Neurodegeneration)
    p(MGI:Vegfc)increases, causesNoChangea(MESH:"Lymphatic Vessels")
    a(CHEBI:nifedipine)increases, causesNoChangebp(GO:"calcium-mediated signaling")
    a(CHEBI:"amyloid-beta")increases, decreasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
    a(MESH:Nicotine)increases, decreasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
    HasQuantitativeInformation -
      +
    p(HGNC:TTBK2, var("p.Glu450*"))increases, decreasesp(HGNC:TTBK2)
    p(HGNC:PRKN, var("?"))increases, decreasesp(HGNC:PRKN)
    Km_ATP -
      +
    p(HGNC:OTUB1)increases, decreasesp(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
    bp(MESH:"Oxidative Stress")increases, causesNoChangebp(GO:"apoptotic process")
    MeasurementType -
      +
    p(HGNC:HSPB1)increases, decreases, causesNoChangep(HGNC:MAPT)
    p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))increases, decreasescomplex(GO:"protein phosphatase type 2A complex")
    p(HGNC:OTUB1)increases, decreases, regulatesp(HGNC:MAPT)
    p(MGI:Chrna7)increases, decreasesp(MGI:Map2)
    MeasurementValue -
      +
    a(CHEBI:"Hsp90 inhibitor")increases, decreasesp(HGNC:MAPT)
    a(MESH:Nicotine)increases, decreasesp(HGNC:CHRNA7)
    a(CHEBI:nicotine)increases, decreases, regulatesa(CHEBI:dopamine)
    Method -
      +
    a(CHEBI:Anatabine)increases, decreasespath(MESH:Anxiety)
    path(HBP:"isolation rearing")increases, decreasesr(RGD:Bdnf)
    PublicationType -
      +
    p(HGNC:MAPT, var("p.Ala152Thr"))decreases, causesNoChangep(HGNC:MAPT)
    a(CHEBI:epoxomicin)increases, decreasesp(HGNC:MAPT)
    path(MESH:"Alcohol Drinking")increases, decreases, causesNoChangep(HGNC:ADNP)
    Research_Model -
      +
    a(CHEBI:rosiglitazone)increases, decreasesa(CHEBI:"amyloid-beta")
    p(MGI:Mapt, var("p.Pro301Leu"))increases, decreasesp(MGI:Mapt)
    Tau_Epitope -
      +
    p(HGNC:BACE1, frag("67_78"))increases, decreasesa(HBP:"sAPP-alpha")
    a(CHEBI:nicotine)increases, causesNoChangea(HBP:"alpha-4-containing nAChR")
    path(MESH:"Alzheimer Disease")increases, decreases, association, positiveCorrelationa(CHEBI:"amyloid-beta")
    p(HGNC:TNF)increases, causesNoChangep(HGNC:STAT3, pmod(Ph))
    Vmax -
      +
    path(MESH:D060825)increases, causesNoChangep(HGNC:CHAT)
    p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))increases, causesNoChangep(MGI:Mapt)
    path(HBP:"isolation rearing")increases, decreasesr(RGD:Ntrk2)
    - - - - -
    - -

    Warnings

    -
    - - -

    Warning Statistics

    -
    -
    -
    - - - -

    - Most Frequent 14 Errors -

    - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
    ErrorFrequency
    "Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace5
    "Nitrosative Stress" is not in the MESH namespace4
    "neuroinflammatory response" is not in the GO namespace4
    "Tau antibody, CP13" is not in the HBP namespace2
    "soluble tau" is not in the HBP namespace2
    "3-3' dityrosine cross-linking" is not in the HBP namespace2
    "CA1 interneuron" is not in the HBP namespace2
    - - - - - -

    All Errors - 28 -

    - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
    PathLineBELMessage
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel142complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, PHF1")))"Tau antibody, PHF1" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel143complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13")))"Tau antibody, CP13" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel145p(MGI:Tfeb) cnc p(MGI:Cp13)"Cp13" is not in the MGI namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel148complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT8")))"Tau antibody, AT8" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel149complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, AT180")))"Tau antibody, AT180" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel150complex(p(MGI:Mapt, pmod(Ph)), p(HBP:"Tau antibody, CP13")))"Tau antibody, CP13" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel154p(MGI:Tfeb) -| p(HBP:"soluble tau",pmod(Ph))"soluble tau" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel155p(MGI:Tfeb) cnc p(HBP:"soluble tau")"soluble tau" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/martini‐stoica2018.bel167complex(p(HBP:"Tau antibody,MC1"))"Tau antibody,MC1" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel109p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel110p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel111p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel112p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel132p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel613a(CHEBI:"amyloid-beta") -> bp(MESH:"Nitrosative Stress")"Nitrosative Stress" is not in the MESH namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel614bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164))"Nitrosative Stress" is not in the MESH namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel615bp(MESH:"Nitrosative Stress") pos p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208))"Nitrosative Stress" is not in the MESH namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel857a(CHEBI:peroxynitrite) -> bp(MESH:"Nitrosative Stress")"Nitrosative Stress" is not in the MESH namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel925a(CHEBI:peroxynitrite) -> a(HBP:"3-3' dityrosine cross-linking")"3-3' dityrosine cross-linking" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel926a(HBP:"3-3' dityrosine cross-linking") pos a(HBP:"paired helical filaments")"3-3' dityrosine cross-linking" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1493p(MGI:Ttbk1) -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1867act(p(MGI:Dapk1)) neg tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron"))"CA1 interneuron" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel1868tloc(a(CHEBI:neurotransmitter), fromLoc(HBP:"entorhinal cortex layer 2"), toLoc(HBP:"CA1 interneuron")) pos bp(GO:memory)"CA1 interneuron" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2483act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) pos a(HBP:"long-term depression")"long-term depression" is not in the HBP namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2951a(CHEBI:lipopolysaccharide) -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2952a(CHEBI:"amyloid-beta") -> bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel2953a(HBP:"C-30-27") -| bp(GO:"neuroinflammatory response")"neuroinflammatory response" is not in the GO namespace
    /Users/cthoyt/dev/knowledge/hbp_knowledge/tau/nestor/tau_modifications.bel3401a(HBP:MPT0G211) -> p(HBP:"Blood-Brain Barrier")"Blood-Brain Barrier" is not in the HBP namespace
    - -
    + + p(HGNC:BACE1) + increases, decreases, causesNoChange, association + p(HGNC:APP) + + + + p(MGI:Tfeb) + decreases, causesNoChange + p(MGI:Mapt, pmod(Ph)) + + + + a(MESH:antalarmin) + increases, decreases + p(RGD:Drd3) + + + + a(PUBCHEM:9832404) + increases, decreases, causesNoChange, association + p(HGNC:DLG4) + + + + p(HBP:"Tau oligomers", var("p.Lys280del")) + increases, causesNoChange + bp(GO:"cell death") + + + + a(CHEBI:Nilvadipine) + increases, decreases + a(CHEBI:"amyloid-beta polypeptide 42") + + + + a(CHEBI:lactacystin) + increases, decreases + p(HGNC:MAPT) + + + + bp(GO:macroautophagy) + decreases, causesNoChange + p(MGI:Mapt, var("p.Pro301Leu")) + + + + a(CHEBI:"amyloid-beta") + increases, decreases + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + p(HGNC:HSPA1A) + increases, decreases + a(HBP:"Tau aggregates") + + + + a(CHEBI:donepezil) + increases, decreases + p(HGNC:ACHE) + + + + a(CHEBI:heparin) + increases, decreases, causesNoChange + a(HBP:"Tau aggregates") + + + + a(CHEBI:"amyloid-beta") + decreases, causesNoChange, positiveCorrelation, increases, association + p(HGNC:CHRNA7) + + + + p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + negativeCorrelation, decreases, causesNoChange + a(MESH:Microglia) + + + + p(HGNC:ACHE) + increases, decreases, directlyIncreases + a(CHEBI:acetylcholine) + + + + path(MESH:"Alzheimer Disease") + decreases, positiveCorrelation, negativeCorrelation, increases, association + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + a(CHEBI:chlorobutanol) + decreases, causesNoChange + path(MESH:Smell) + + + + a(HBP:HBP00092) + increases, causesNoChange + bp(GO:"apoptotic process") + + + + complex(GO:"NF-kappaB complex") + increases, decreases + p(HGNC:BCL2L1) + + + + a(HBP:"4-OH-GTS-21") + decreases, causesNoChange + a(MESH:"Cholinergic Neurons") + + + + path(MESH:D000544) + decreases, causesNoChange + p(HGNC:ACHE) + + + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + increases, causesNoChange + path(MESH:"Alcohol Drinking") + + + + p(HGNC:SYK) + increases, decreases + a(CHEBI:"amyloid-beta") + + + + a(PUBCHEM:11249342) + increases, causesNoChange + path(MESH:Vomiting) + + + + a(GO:"neurofibrillary tangle") + increases, decreases + bp(GO:"cell death") + + + + a(PUBCHEM:9832404) + increases, causesNoChange + p(HGNC:SLC17A7) + + + + bp(GO:autophagy) + increases, negativeCorrelation, decreases + a(CHEBI:lipid) + + + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") + increases, decreases + a(CHEBI:"amyloid-beta") + + + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + decreases, causesNoChange + path(MESH:"Motor Activity") + + + + p(HGNC:AQP4) + increases, decreases, association + a(CHEBI:"amyloid-beta") + + + + bp(GO:"lysosomal protein catabolic process") + increases, decreases + a(CHEBI:"amyloid-beta") + + + + a(PUBCHEM:11249342) + increases, causesNoChange + path(MESH:Nausea) + + + + complex(GO:"NF-kappaB complex") + increases, decreases, regulates + p(HGNC:BACE1) + + + + bp(MESH:Autophagy) + increases, decreases + a(HBP:"Tau aggregates") + + + + a(CHEBI:"methylene blue") + increases, decreases + p(HGNC:MARK4) + + + + bp(GO:macroautophagy) + increases, decreases + p(MGI:Mapt) + + + + a(HBP:HBP00055) + increases, decreases + p(MGI:Mapt) + + + + bp(GO:"chaperone-mediated autophagy") + increases, causesNoChange + p(MGI:Mapt, var("p.Pro301Leu")) + + + + a(MESH:antalarmin) + increases, decreases + r(RGD:Ntrk2) + + + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") + increases, decreases + a(CHEBI:"amyloid-beta polypeptide 42") + + + + bp(GO:aging) + increases, negativeCorrelation, decreases + p(HGNC:MAPT) + + + + a(CHEBI:nicotine) + decreases, causesNoChange, increases, association, regulates + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + a(HBP:"amyloid-beta oligomers") + increases, decreases + p(HGNC:MAPT) + + + + p(HGNC:BSG) + decreases, causesNoChange + a(CHEBI:"amyloid-beta") + + + + p(MGI:Vegfc) + increases, causesNoChange + a(CHEBI:macromolecule) + + + + p(FPLX:"CCT_complex") + increases, decreases + a(HBP:"huntingtin aggregates") + + + + a(MESH:antalarmin) + decreases, causesNoChange + path(HBP:"isolation rearing") + + + + a(CHEBI:"amyloid-beta") + increases, decreases, positiveCorrelation + complex(GO:"NF-kappaB complex") + + + + a(CHEBI:nicotine) + increases, causesNoChange, regulates + p(FPLX:CHRN) + + + + p(HGNC:APOE) + increases, decreases, regulates + a(CHEBI:"amyloid-beta") + + + + a(PUBCHEM:675434) + increases, decreases + p(HGNC:MAPT) + + + + p(HGNC:MAPT) + increases, causesNoChange + bp(GO:"retrograde axonal protein transport") + + + + a(MESH:antalarmin) + increases, decreases + p(RGD:Drd2) + + + + p(FPLX:mTORC1) + increases, decreases + bp(GO:macroautophagy) + + + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) + increases, decreases + path(MESH:Smell) + + + + a(CHEBI:sirolimus) + increases, decreases + p(HGNC:MAPT) + + + + p(MGI:Crh) + decreases, causesNoChange + a(MESH:Progesterone) + + + + + -

    Biogrammar

    -
    -

    - Regulatory Pairs - 20 +

    + Unstable Pairs + 112

    +
    +
    Chaotic Pairs
    +
    Nodes that mutually increase each other, such as when both A increases + B and B increases A. +
    +
    Dampened Pairs
    +
    Nodes that mutually decrease each other, such as when both A decreases + B and B decreases A. +
    +

    - These pairs of nodes represent motifs like A increases B and - B decreases A. + While neither chaotic nor dampened pairs are biologically invalid, they require + additional context to understand their regulation.

    - +
    + @@ -131856,2006 +148472,2472 @@

    - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + - - + + + + - + - - + + + - - + + + - - + + + + - + - - + + + - - + + + - -
    Type Node A Node B
    bp(GO:"late endosomal microautophagy")p(MGI:Mapt)Chaoticp(FPLX:NFkappaB)p(HGNC:IL1B)
    Chaoticp(HGNC:HSF1)p(HGNC:HSF1)
    Chaoticp(FPLX:NFkappaB)p(HGNC:TNF)
    Chaoticp(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
    Chaoticbp(GO:"astrocyte activation")p(HGNC:IL1B)
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:IL1B)
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
    Chaotica(MESH:Proteins)p(HGNC:PSMD14)
    Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:TREM2)
    Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)
    Chaotica(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))
    Chaotica(MESH:"Lymphatic Vessels")bp(MESH:"Cerebrovascular Circulation")
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP3)
    Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")
    Chaotica(CHEBI:dextran)a(CHEBI:dextran)
    Chaotica(CHEBI:"amyloid-beta polypeptide 42")r(HGNC:"BACE1-AS")
    Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)
    Chaoticp(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Chaotica(CHEBI:nicotine)p(FPLX:PI3K)
    Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")
    Chaotica(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
    Chaoticbp(GO:"apoptotic process")p(HGNC:CASP6)
    Chaotica(MESH:"Lymphatic Vessels")p(MGI:Vegfc)
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))
    Chaoticp(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
    Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"signal transducer and activator of transcription 3")
    Chaoticp(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))
    Chaotica(MESH:Neurons)p(HGNC:MAPT)
    Chaoticp(HGNC:PRNP)p(HGNC:PRNP)
    Chaoticp(FPLX:NFkappaB)p(FPLX:NFkappaB)
    p(HGNC:MAPT)bp(HP:Neurodegeneration)Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:BACE1)
    p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")Chaoticp(HGNC:ERN1)p(HGNC:ERN1, pmod(Ph))
    a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:LIF)
    p(HGNC:CHRNA7)complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:TNF)
    p(HGNC:PIN1)p(HGNC:SMAD2)Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT)
    path(MESH:Tauopathies)p(MGI:Tfeb)Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))
    complex(GO:"proteasome complex")a(CHEBI:"amyloid-beta")Chaoticbp(GO:"astrocyte activation")p(HGNC:IL18)
    p(HGNC:CHRNA7)a(CHEBI:anandamide)Chaoticp(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    bp(GO:autophagy)p(HGNC:HTT, var("?"))Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:IL6)
    complex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)Chaotica(CHEBI:nicotine)p(FPLX:"CAMK2_complex")
    a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:AK1)Chaoticp(HGNC:MAPT)p(HGNC:MAPT)
    a(GO:synapse)p(HGNC:MAPT)Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP2)
    Chaotic bp(GO:autophagy)p(HGNC:SNCA)p(HGNC:MAPT, pmod(Ph, Ser, 262))
    p(MGI:Mapt, var("p.Pro301Leu"))bp(GO:macroautophagy)Chaotica(CHEBI:"amyloid-beta")p(HGNC:RELA)
    p(HGNC:TNF)a(CHEBI:nicotine)Chaoticp(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
    a(MESH:Neurons)p(HGNC:MAPT)Chaoticcomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPME1)
    Chaotic a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")p(HGNC:MMP9)
    bp(GO:autophagy)p(HGNC:MAPT)Chaotica(CHEBI:acetylcholine)p(HGNC:CHRM1)
    bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)Chaoticcomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:MAPT, pmod(Ph))
    - - - -

    - Contradictory Pairs - 134 -

    -

    - These pairs of nodes have a contradiction in their causal relationships, meaning they - have more than one of INCREASES, DECREASES, or CAUSES NO - CHANGE. This may be due to different experimental conditions, so these statements - need to be carefully considered in analyses. -

    - - - - - - - - - - - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + + + + + + + + + + + + + - - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + + + + + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + +
    SourceRelationsTarget
    p(MGI:Chrna7)decreases, increasesp(MGI:Map2)Chaoticbp(GO:"depolarization of postsynaptic membrane")bp(GO:"long-term synaptic potentiation")
    p(HGNC:WNT3A)decreases, increasesChaotic a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
    p(HGNC:CDC37)decreases, increasesp(HGNC:MAPT)Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))
    bp(GO:autophagy)decreases, increasespath(HBP:neurotoxicity)Chaoticp(HGNC:MAPT, pmod(Ph, Tyr, 18))p(HGNC:SYK)
    a(HBP:"amyloid-beta oligomers")decreases, increasesp(HGNC:DLG4)Chaoticcomplex(a(MESH:Ubiquitin), p(HGNC:UBA3))p(HGNC:UBA2)
    a(CHEBI:lactacystin)decreases, increasesp(HGNC:MAPT)Chaotica(CHEBI:"amyloid-beta")p(HGNC:APOE)
    path(MESH:D000544)decreases, causesNoChangep(HGNC:ACHE)Chaotica(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")
    bp(MESH:Aging)decreases, increasesp(FPLX:HSP90)Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:CNTF)
    bp(GO:autophagy)decreases, increases, negativeCorrelationa(CHEBI:lipid)Chaotica(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")
    a(CHEBI:rosiglitazone)decreases, increasesa(CHEBI:"amyloid-beta")Chaotica(GO:lysosome)a(GO:lysosome)
    p(MGI:Chrna7)decreases, increasesa(CHEBI:"amyloid-beta")Chaotica(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
    a(CHEBI:"amyloid-beta")decreases, increasesa(MESH:"alpha7 Nicotinic Acetylcholine Receptor")Chaotica(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")
    p(HGNC:PPP2CA, pmod(Ph, Tyr, 307))decreases, increasescomplex(GO:"protein phosphatase type 2A complex")Chaotica(MESH:Proteins)a(MESH:Proteins)
    a(CHEBI:nifedipine)increases, causesNoChangebp(GO:"calcium-mediated signaling")Chaotica(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
    p(HGNC:BACE1, frag("228_236"))decreases, increasesa(HBP:"sAPP-alpha")Chaotica(CHEBI:nicotine)p(HGNC:CHRNA7)
    p(HGNC:BSG)decreases, causesNoChangea(CHEBI:"amyloid-beta")Chaoticbp(GO:"microglial cell activation")p(HGNC:IL1B)
    a(HBP:"4-OH-GTS-21")decreases, causesNoChangea(MESH:"Cholinergic Neurons")Chaoticbp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))
    a(PUBCHEM:675434)causesNoChange, increasesp(FPLX:Proteasome)Chaotica(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")
    a(CHEBI:"chondroitin sulfate")decreases, causesNoChangea(HBP:"Tau isoform F (441 aa)")Chaotica(CHEBI:"amyloid-beta")p(FPLX:TLR)
    a(CHEBI:rolipram)decreases, increasesp(HGNC:MAPT)Chaoticcomplex(p(HGNC:CDK5), p(HGNC:CDK5R1))p(HGNC:CDK5)
    bp(MESH:"Heat-Shock Response")increases, causesNoChangep(NCBIGENE:492507)Chaoticp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    bp(GO:autophagy)decreases, increasesp(HGNC:APP)Chaoticp(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")
    p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))increases, causesNoChangep(MGI:Mapt)Chaoticbp(GO:"microglial cell activation")p(HGNC:IL18)
    a(CHEBI:galanthamine)decreases, increasesp(HGNC:ACHE)Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))
    a(CHEBI:"amyloid-beta")decreases, increasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))Chaotica(CHEBI:acetylcholine)a(CHEBI:choline)
    Chaotic a(CHEBI:"amyloid-beta")decreases, causesNoChangepath(HBP:Neurodegeneration)p(HGNC:APP)
    p(HGNC:PRKN, var("?"))decreases, increasesp(HGNC:PRKN)Chaoticp(HGNC:MAPT)p(HGNC:SQSTM1)
    a(CHEBI:sirolimus)decreases, increasesp(HGNC:MAPT)Chaotica(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))
    a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")decreases, increasesa(CHEBI:"amyloid-beta polypeptide 42")Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))
    bp(GO:"chaperone-mediated autophagy")increases, causesNoChangep(MGI:Mapt, var("p.Pro301Leu"))Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")
    complex(a(GO:"proteasome complex"), p(HGNC:USP14))decreases, increasesbp(GO:"protein catabolic process")Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))
    a(CHEBI:Anatabine)decreases, causesNoChangebp(HBP:Astrogliosis)Dampenedp(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
    p(HGNC:PPP2CB, pmod(Ph, Tyr, 307))decreases, increasescomplex(GO:"protein phosphatase type 2A complex")Dampenedp(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))
    bp(GO:autophagy)decreases, association, increasesp(HGNC:MAPT)Dampenedp(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))
    p(HGNC:TFEB)decreases, increases, regulatesa(CHEBI:"amyloid-beta")Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
    p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))decreases, causesNoChange, negativeCorrelationa(MESH:Microglia)Dampenedp(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
    p(MGI:Mapt, var("p.Ala152Thr"))decreases, increasesp(MGI:Mapt)Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))
    p(FPLX:"CCT_complex")decreases, increasesa(HBP:"huntingtin aggregates")Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
    a(CHEBI:nicotine)causesNoChange, increasesa(HBP:"alpha-4-containing nAChR")Dampenedp(HBP:"cis p-tau")p(HGNC:PIN1)
    a(CHEBI:Anatabine)decreases, causesNoChangep(MGI:Ifng)Dampenedp(HBP:"cis p-tau")p(HBP:"cis p-tau")
    bp(MESH:Autophagy)decreases, increasesp(HBP:"Tau C3")Dampeneda(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
    Dampeneda(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
    Dampeneda(CHEBI:"amyloid-beta")p(HGNC:BCL2L1)
    Dampened a(CHEBI:"amyloid-beta")association, increases, decreases, positiveCorrelation, causesNoChange p(HGNC:CHRNA7)
    p(MGI:Vegfc)increases, causesNoChangea(CHEBI:macromolecule)Dampenedcomplex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7))
    bp(MESH:Autophagy)increases, causesNoChangeDampenedbp(GO:autophagy) p(HGNC:MAPT)
    a(CHEBI:"dimethyl fumarate")increases, causesNoChangep(HGNC:NFE2L2)Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))
    p(HGNC:AQP4)decreases, association, increasesa(CHEBI:"amyloid-beta")Dampeneda(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)
    a(CHEBI:"amyloid-beta")decreases, increasesbp(GO:memory)Dampenedp(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
    bp(GO:macroautophagy)decreases, causesNoChangep(MGI:Mapt, var("p.Pro301Leu"))Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
    path(MESH:"Alzheimer Disease")positiveCorrelation, association, causesNoChange, increasesp(HGNC:MAPT)Dampeneda(HBP:"Tau aggregates")complex(GO:"proteasome complex")
    p(HGNC:ABCB1)decreases, increasesDampenedp(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
    Dampeneda(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")
    p(HGNC:ACHE)directlyIncreases, decreases, increasesa(CHEBI:acetylcholine)Dampenedp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))
    p(FPLX:mTORC1)decreases, increasesp(HGNC:TFEB)Dampenedcomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
    bp(GO:"lysosomal protein catabolic process")decreases, increasesa(CHEBI:"amyloid-beta")Dampeneda(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
    a(MESH:Liver)decreases, increasesa(CHEBI:"amyloid-beta")Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))
    a(CHEBI:chloroquine)decreases, increasesp(HGNC:MAPT)Dampeneda(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
    a(CHEBI:"methylene blue")decreases, increasesp(HGNC:MARK4)Dampenedp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
    + + + +

    + Contradictory Triplets + 1251 +

    +

    + Analysis of triple stability comes from a deep graph theoretic background. It + identifies triangles within the graph that have logically inconsistent relations. +

    +
    +
    Separately Unstable Triplet
    +
    When both A positiveCorrelation B, B negativeCorrelation + C, but C positiveCorrelation A. +
    +
    Mutually Unstable Triplets
    +
    When both A negativeCorrelation B, B negativeCorrelation + C, and C negativeCorrelation A. +
    +
    Jens Contradictory Triplet
    +
    When A increases B, A decreases C, and C + positiveCorrelation A. +
    +
    Increase Mismatch Triplet
    +
    When A increases B, A increases C, and C + negativeCorrelation A. +
    +
    Decrease Mismatch Triplet
    +
    When A decreases B, A decreases C, and C + negativeCorrelation A. +
    +
    + + + + + + + + + + + - - - + + + + - - + + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - + + + + + + - - - - + + + - - - + + + + - - - + + + + + + - - + - - - + + + + - - - + + + + + - - + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + + - - + + + + + - - - - - + + + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - + + + + + + + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + + + - - + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - + + + - - - + + + + - - + + + + - - + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - + + + + + + + + + + + + + + + + + - - + + + - - - + + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - -
    TypeNode ANode BNode C
    p(HGNC:TTBK2, var("p.Glu450*"))decreases, increasesp(HGNC:TTBK2)Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 231))
    a(MESH:Neurons)increases, causesNoChangeSeparate p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    a(CHEBI:epoxomicin)decreases, increasesSeparate p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    a(GO:"neurofibrillary tangle")decreases, increasesbp(GO:"cell death")Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
    a(CHEBI:donepezil)decreases, increasesp(HGNC:ACHE)Separatep(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    a(CHEBI:heparin)decreases, causesNoChange, increasesa(HBP:"Tau aggregates")Separatep(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    p(MGI:Vegfc)increases, causesNoChangea(MESH:"Lymphatic Vessels")Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
    a(MESH:antalarmin)causesNoChange, increasesa(MESH:"Embryonic Structures")Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
    p(HGNC:TNF)causesNoChange, increasesp(HGNC:STAT3, pmod(Ph))Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET, frag("?"))
    p(HGNC:SYK)decreases, increasesSeparate a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta polypeptide 42")path(MESH:"Alzheimer Disease")
    Separatepath(MESH:"Alzheimer Disease")bp(GO:"neuron death") bp(MESH:Autophagy)decreases, increasesa(HBP:"Tau aggregates")
    p(HGNC:PICALM)decreases, positiveCorrelation, increasesSeparate a(CHEBI:"amyloid-beta")bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
    a(PUBCHEM:11249342)increases, causesNoChangepath(MESH:Nausea)Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
    a(CHEBI:ambroxol)decreases, increasesp(HGNC:SNCA)Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    Separatepath(MESH:"Alzheimer Disease") p(HGNC:MAPT)increases, causesNoChangebp(GO:"anterograde axonal protein transport")p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
    p(HGNC:BCHE)directlyIncreases, decreasesa(CHEBI:acetylcholine)Separatep(HGNC:CHRNA7)bp(GO:cognition)path(MESH:"Alzheimer Disease")
    a(CHEBI:Anatabine)decreases, causesNoChangep(MGI:Tnf)Separatep(HGNC:GSK3B)bp(GO:"apoptotic process")p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Separate path(MESH:"Alzheimer Disease")positiveCorrelation, association, decreases, increasesa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:MAPT)
    a(CHEBI:"Hsp90 inhibitor")decreases, increasesSeparatepath(MESH:"Alzheimer Disease") p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
    a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")decreases, increasesa(CHEBI:"amyloid-beta")Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    p(FPLX:mTORC1)decreases, increasesbp(GO:macroautophagy)Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A)
    p(HGNC:CHAT)decreases, increases, directlyIncreasesa(CHEBI:acetylcholine)Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)path(MESH:Dementia)
    a(MESH:antalarmin)decreases, increasesp(RGD:Drd2)Separatea(CHEBI:"amyloid-beta")p(HGNC:PICALM)path(MESH:"Alzheimer Disease")
    p(HGNC:APOE)decreases, increases, regulatesa(CHEBI:"amyloid-beta")Separatepath(MESH:"Alzheimer Disease")p(HGNC:BAG1)p(HGNC:MAPT, pmod(Ph))
    a(HBP:HBP00092)causesNoChange, increasesbp(GO:"apoptotic process")Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET)
    a(MESH:Nicotine)decreases, increasesp(HGNC:CHRNA7)Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
    Separate path(MESH:"Alzheimer Disease")association, increases, negativeCorrelation, decreases, positiveCorrelationp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    Mutualbp(GO:aging)complex(GO:"proteasome complex") p(HGNC:MAPT)decreases, causesNoChange, negativeCorrelationa(GO:synapse)
    a(CHEBI:nicotine)association, increases, decreases, causesNoChange, regulatesp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")Mutualbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)path(MESH:"Alzheimer Disease")
    p(HGNC:RAB5A)decreases, increasesMutualbp(GO:"lysosomal protein catabolic process") bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
    a(CHEBI:"amyloid-beta")decreases, increasesa(CHEBI:acetylcholine)Mutualbp(GO:"proteasomal protein catabolic process")bp(GO:autophagy)path(MESH:"Alzheimer Disease")
    a(MESH:"SNARE Proteins")increases, causesNoChangep(HGNC:CHRNA7)Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")
    p(HGNC:CHRM1)increases, causesNoChangebp(GO:"ERK1 and ERK2 cascade")Jensa(MESH:Microglia)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")
    p(HBP:"Tau oligomers", var("p.Lys280del"))increases, causesNoChangebp(GO:"cell death")Jensa(CHEBI:sirolimus)p(HGNC:MAPT)p(HGNC:MAPT)
    p(HGNC:CHRNA7)association, increases, decreases, positiveCorrelation, regulatesa(CHEBI:"amyloid-beta")Jensa(GO:microtubule)a(HBP:"Tau oligomers")p(HGNC:MAPT)
    a(MESH:antalarmin)decreases, increasesr(RGD:Ntrk2)Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Lys280del"))
    a(CHEBI:"amyloid-beta polypeptide 42")decreases, causesNoChangep(ECCODE:"2.7.11.31")Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)
    path(MESH:"Alzheimer Disease")association, increases, negativeCorrelation, decreases, positiveCorrelationp(HGNC:CHRNA7)Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:memory)
    p(HGNC:TTBK2, var("p.Asp449*"))decreases, increasesp(HGNC:TTBK2)Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    a(CHEBI:Thrombin)causesNoChange, increasesp(HGNC:MAPT, frag("561_685"))Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)
    p(HGNC:HSPA1A)decreases, increasesa(HBP:"Tau aggregates")Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HBP:"Tau aggregates")
    a(PUBCHEM:675434)decreases, increasesJensa(CHEBI:"okadaic acid")p(FPLX:PPP2)path(MESH:Neoplasms)
    Jensp(HGNC:AK1)p(HGNC:APP) p(HGNC:MAPT)
    p(MGI:Chrna7)decreases, increasespath(MESH:"Spatial Memory")Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:IL1B)
    p(HGNC:HSPB1)decreases, increases, causesNoChangep(HGNC:MAPT)Jensp(HGNC:IL6)p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    p(HGNC:CHRNA7)decreases, increases, regulatesa(CHEBI:"glutamate(2-)")Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 214))path(MESH:"Alzheimer Disease")
    complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A))decreases, increasesbp(GO:"anterograde axonal protein transport")Jensp(HGNC:MAPT, frag("?"))p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")
    a(MESH:antalarmin)decreases, increasesp(RGD:Drd3)Jensa(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)
    a(CHEBI:nicotine)decreases, increasesp(HBP:"alpha-4 beta-2 nAChR")Jensa(CHEBI:"potassium(1+)")complex(GO:"inflammasome complex")p(HGNC:IL1B)
    a(CHEBI:rosiglitazone)decreases, causesNoChangea(HBP:HBP00018)Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Supranuclear Palsy, Progressive")
    bp(GO:"response to endoplasmic reticulum stress")decreases, increasesbp(GO:"cell death")Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:nilotinib) bp(GO:macroautophagy)decreases, increasesp(MGI:Mapt)p(HGNC:ABL1)
    a(MESH:Nicotine)decreases, increasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))Jensa(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)
    p(HGNC:TTBK2, var("p.Tyr448*"))decreases, increasesp(HGNC:TTBK2)Jensa(CHEBI:"3',5'-cyclic AMP")a(CHEBI:rolipram)p(HGNC:MAPT)
    a(CHEBI:rivastigmine)decreases, increasesp(HGNC:ACHE)Jensp(FPLX:CALM)p(HBP:"DAPK, basic loop (BL) motif")p(HGNC:DAPK2)
    p(HGNC:BACE1, frag("67_78"))decreases, increasesa(HBP:"sAPP-alpha")Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    a(CHEBI:Nilvadipine)decreases, increasesa(CHEBI:"amyloid-beta polypeptide 42")Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    p(HGNC:MAPT, var("p.Ala152Thr"))decreases, causesNoChangeJenscomplex(p(HGNC:FYN), p(HGNC:MAPT)) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    p(MGI:Tfeb)decreases, causesNoChangep(MGI:Mapt, pmod(Ph))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:WNT3A)
    p(HGNC:IDE)decreases, increasesJens a(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:DKK1)
    Jens p(HGNC:MAPT)decreases, increases, regulatesa(MESH:Neurons)p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
    a(MESH:Kidney)decreases, increasesJens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:RELA)
    p(HGNC:MAPT)increases, causesNoChangebp(GO:"retrograde axonal protein transport")Jensbp(GO:"neuron death")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
    a(HBP:HBP00055)decreases, increasesp(MGI:Mapt)Jensa(CHEBI:"amyloid-beta")g(HBP:"APOE e4")p(HGNC:APP)
    p(HGNC:BACE1)decreases, association, causesNoChange, increasesp(HGNC:APP)Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00018)p(HGNC:TFEB)
    a(HBP:"amyloid-beta oligomers")decreases, increasesJensbp(GO:aging)p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:sirolimus)bp(GO:cognition)path(MESH:"Alzheimer Disease")
    Jensa(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    bp(GO:aging)decreases, increases, negativeCorrelationJensp(HGNC:GSK3B) p(HGNC:MAPT)p(HGNC:SYK)
    a(MESH:antalarmin)decreases, causesNoChangepath(HBP:"isolation rearing")Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(MESH:Tauopathies)
    p(HGNC:ACE)decreases, increasesJensp(FPLX:PPP2)p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Jensbp(GO:macroautophagy)p(HGNC:MAPT, var("p.Ala152Thr"))p(MGI:Mapt)
    Jensp(HGNC:DAPK1)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))
    Jensp(HGNC:ABL1)p(HGNC:MAPT, pmod(Ph, Tyr, 394))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")
    a(CHEBI:nicotine)increases, causesNoChange, regulatesp(FPLX:CHRN)Jensbp(GO:locomotion)composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC))p(HGNC:MAPT)
    p(MGI:Crh)decreases, causesNoChangea(MESH:Progesterone)Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP2)
    path(HBP:"isolation rearing")decreases, increasesr(RGD:Ntrk2)Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    path(HBP:"isolation rearing")decreases, increasesr(RGD:Bdnf)Jensp(FPLX:ERK)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    path(MESH:D060825)causesNoChange, increasesp(HGNC:CHAT)Jensbp(GO:"axonal transport")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)
    a(MESH:Nicotine)decreases, increasesp(MESH:"Receptors, GABA")Jensp(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT)
    a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")decreases, increasesbp(HP:Neurodegeneration)Jensm(MIRBASE:"hsa-mir-146a")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    p(MGI:Mapt, var("p.Pro301Leu"))decreases, increasesp(MGI:Mapt)Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
    a(CHEBI:nicotine)decreases, increases, regulatesa(CHEBI:dopamine)Jensa(GO:"neurofibrillary tangle")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    a(PUBCHEM:11249342)increases, causesNoChangepath(MESH:Vomiting)Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
    - - - -

    - Unstable Pairs - 92 -

    -
    -
    Chaotic Pairs
    -
    Nodes that mutually increase each other, such as when both A increases - B and B increases A. -
    -
    Dampened Pairs
    -
    Nodes that mutually decrease each other, such as when both A decreases - B and B decreases A. -
    -
    -

    - While neither chaotic nor dampened pairs are biologically invalid, they require - additional context to understand their regulation. -

    - - - - - - - - - + + + + + + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - + - + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + - + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + - + + - + + - - - - - - - + - - - + + + + - + - + + - - + + + - - - + + + + - - - + + + + - - - + + + + - + - + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + + + + + + + + - + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + + - + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + + + + + + + + - + + - - - + + + + - + - + + - - - + + + + - + - + + - - - + + + + - - - + + + + - - + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - - - + + + + - + + - - - + + + + - - - + + + + - -
    TypeNode ANode B
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:BACE1)
    Chaoticcomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPME1)Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(MESH:Synapses)p(FPLX:PI3K)
    Jensa(CHEBI:nicotine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
    Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:donepezil)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
    ChaoticJens a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)a(MESH:Microglia)p(HGNC:MAPT)
    Chaoticbp(GO:"microglial cell activation")p(HGNC:IL1B)Jensa(CHEBI:"amyloid-beta")bp(GO:"cerebrospinal fluid circulation")bp(GO:aging)
    Chaotica(CHEBI:acetylcholine)a(CHEBI:choline)Jensa(CHEBI:Thrombin)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))Jensa(MESH:methyllycaconitine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
    Chaoticp(HGNC:MAPT)p(HGNC:SQSTM1)Jensa(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")complex(GO:"NF-kappaB complex")
    Chaotica(HBP:"Tau aggregates")a(HBP:"Tau aggregates")Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Chaoticp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
    ChaoticJens a(CHEBI:"amyloid-beta")p(HGNC:MMP3)a(CHEBI:Anatabine)p(HGNC:CHRNA7)
    Chaotica(MESH:"Lymphatic Vessels")bp(MESH:"Cerebrovascular Circulation")Jensa(GO:lysosome)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))
    Chaotica(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")Jensa(CHEBI:"reactive oxygen species")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Chaoticbp(GO:autophagy)p(HGNC:MAPT, pmod(Ph, Ser, 262))Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    Chaoticbp(GO:"astrocyte activation")p(HGNC:IL18)Jensa(CHEBI:nicotine)bp(GO:memory)p(HGNC:CHRNA7)
    Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT)Jensa(CHEBI:"amyloid-beta")a(GO:synapse)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    ChaoticJens a(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")bp(GO:aging)p(HGNC:MAPT)
    ChaoticJensa(CHEBI:"amyloid-beta") a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Chaoticp(HGNC:MAPT, pmod(Ph, Tyr, 18))p(HGNC:SYK)path(MESH:Anxiety)
    Chaoticbp(GO:"microglial cell activation")p(HGNC:IL18)Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
    ChaoticJens a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)bp(GO:aging)p(HGNC:IL1B)
    Chaotica(HBP:"Tau oligomers")Jensp(HGNC:FKBP5) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Chaoticbp(GO:"depolarization of postsynaptic membrane")bp(GO:"long-term synaptic potentiation")Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
    Chaoticp(HGNC:HSF1)p(HGNC:HSF1)Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph))
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BCL2)
    ChaoticJens a(CHEBI:"amyloid-beta")p(FPLX:TLR)bp(GO:"cell death")p(HGNC:CHRNA7)
    Chaotica(MESH:Proteins)p(HGNC:PSMD14)Jensa(GO:lysosome)g(HGNC:APP, var("?"))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP9)Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:OTUB1)
    Chaotica(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))Jensa(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(MESH:Autophagy)
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))Jensp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
    Chaoticp(HGNC:MAPT, pmod(Ph))Jensa(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") path(MESH:"Alzheimer Disease")
    Chaoticp(HGNC:CHRNA7)p(HGNC:CHRNA7)Jensa(CHEBI:scopolamine)a(MESH:VU0357017)bp(GO:"behavioral fear response")
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))Jensa(CHEBI:"amyloid-beta")bp(GO:"Fas signaling pathway")complex(GO:"NF-kappaB complex")
    Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP9)
    Chaoticp(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))Jensa(CHEBI:peroxynitrite)bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
    Chaoticcomplex(a(MESH:Ubiquitin), p(HGNC:UBA3))p(HGNC:UBA2)Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Chaotica(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")Jensp(FPLX:NFkappaB)p(HGNC:BACE1)p(HGNC:UCHL1)
    Chaoticbp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
    Chaoticp(HGNC:PRNP)p(HGNC:PRNP)Jensp(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:PPP1CA)
    Chaoticbp(GO:"apoptotic process")p(HGNC:CASP6)Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Chaotica(GO:lysosome)a(GO:lysosome)Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:TREM2)Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)Jensa(MESH:Neurons)a(PUBCHEM:64627)p(MGI:Adora1)
    Chaoticp(HGNC:ERN1)p(HGNC:ERN1, pmod(Ph))Jensa(CHEBI:cilostazol)bp(GO:macroautophagy)p(HGNC:MAPT, pmod(HBP:HBP00007))
    Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")Jensp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))
    Chaotica(CHEBI:acetylcholine)p(HGNC:CHRM1)Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
    Chaoticbp(GO:"astrocyte activation")p(HGNC:IL1B)Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)
    Chaotica(MESH:Proteins)a(MESH:Proteins)Jensa(CHEBI:"amyloid-beta")a(CHEBI:Anatabine)path(MESH:Anxiety)
    Chaoticp(HGNC:MAPT)p(HGNC:MAPT)Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:LRP1)
    Chaoticp(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))Jensa(PUBCHEM:9832404)bp(GO:"synaptic transmission, glutamatergic")p(HGNC:ADNP)
    Chaoticp(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")Jensbp(GO:autophagy)p(HGNC:APP)p(HGNC:MAPT)
    Chaoticp(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))Jensa(CHEBI:"amyloid-beta")a(MESH:Astrocytes)p(HGNC:IL1B)
    Chaotica(CHEBI:dextran)a(CHEBI:dextran)Jensp(HGNC:MAPT, pmod(Ub))path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP2)Jensbp(GO:"MAPK cascade")p(HBP:"alpha-4 beta-2 nAChR")path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT)
    Chaotica(MESH:Neurons)p(HGNC:MAPT)Jensa(GO:lysosome)a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
    ChaoticJensbp(GO:"depolarization of postsynaptic membrane")complex(GO:"voltage-gated calcium channel complex")p(HBP:"alpha-4 beta-2 nAChR")
    Jens a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:APP)
    Chaoticcomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:MAPT, pmod(Ph))Jensa(MESH:Proteins)a(MESH:Proteins)a(MESH:Proteins)
    Chaotica(CHEBI:nicotine)p(FPLX:"CAMK2_complex")Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:ABCB1)
    Chaotica(MESH:"Lymphatic Vessels")p(MGI:Vegfc)Jensbp(GO:"neuron death")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Chaoticcomplex(p(HGNC:CDK5), p(HGNC:CDK5R1))p(HGNC:CDK5)Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TREM2)
    ChaoticJensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine)p(FPLX:PI3K)a(HBP:"alpha-4 beta-2 nAChR")
    Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))Jensa(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)
    Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:TFEB)
    Dampeneda(CHEBI:acetylcholine)a(CHEBI:acetylcholine)Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
    Dampenedp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))Jensa(CHEBI:"amyloid-beta")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
    Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))Jensp(FPLX:PPP2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Dampenedp(HBP:"cis p-tau")p(HBP:"cis p-tau")Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:TFEB)
    Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")
    Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))Jensa(CHEBI:"proteasome inhibitor")p(HGNC:BAG3)p(HGNC:MAPT)
    Dampenedp(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
    DampenedJensa(CHEBI:ceramide)complex(GO:"protein phosphatase type 2A complex")path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)a(CHEBI:pioglitazone)bp(GO:memory)
    Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)path(HBP:neurotoxicity)
    DampenedJens a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)a(CHEBI:acetylcholine)path(MESH:"Alzheimer Disease")
    Dampenedcomplex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7))Jensp(HGNC:CASP3)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    DampenedJens a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one")p(HGNC:CHRM1)
    Dampenedp(HBP:"cis p-tau")p(HGNC:PIN1)Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")r(HGNC:BACE1)
    Dampeneda(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic")path(MESH:"Alzheimer Disease")
    Dampeneda(CHEBI:"amyloid-beta")Jens a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:memory)
    Dampenedp(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP3)
    Dampeneda(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)Jensa(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL18)
    Dampeneda(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))Jensp(HGNC:DAPK1)p(HGNC:MAPT)p(HGNC:MAPT)
    Dampenedp(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 290))path(MESH:"Alzheimer Disease")
    Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))Jensp(HGNC:CAPN2)path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
    Dampenedp(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))Jensp(HGNC:CHRNA4)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Dampenedp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))Jensa(CHEBI:chlorobutanol)a(PUBCHEM:9832404)path(MESH:Smell)
    Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:PI3K)
    Dampeneda(HBP:"Tau aggregates")complex(GO:"proteasome complex")Jensbp(MESH:Aging)p(FPLX:HSP90)p(HGNC:STIP1)
    Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))Jensa(CHEBI:"amyloid-beta")p(FPLX:Proteasome)path(HBP:neurotoxicity)
    DampenedJens bp(GO:autophagy)p(HGNC:HSPB1) p(HGNC:MAPT)
    Dampenedp(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))
    Dampenedcomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))Jensa(CHEBI:staurosporine)bp(GO:"apoptotic process")p(HGNC:CDK5)
    - - - -

    - Contradictory Triplets - 1048 -

    -

    - Analysis of triple stability comes from a deep graph theoretic background. It - identifies triangles within the graph that have logically inconsistent relations. -

    -
    -
    Separately Unstable Triplet
    -
    When both A positiveCorrelation B, B negativeCorrelation - C, but C positiveCorrelation A. -
    -
    Mutually Unstable Triplets
    -
    When both A negativeCorrelation B, B negativeCorrelation - C, and C negativeCorrelation A. -
    -
    Jens Contradictory Triplet
    -
    When A increases B, A decreases C, and C - positiveCorrelation A. -
    -
    Increase Mismatch Triplet
    -
    When A increases B, A increases C, and C - negativeCorrelation A. -
    -
    Decrease Mismatch Triplet
    -
    When A decreases B, A decreases C, and C - negativeCorrelation A. -
    -
    - - - - - - - - - - - - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - + - - + + - + + + - - - - - - + + + + - + + - - + - - - - + + + + - - - - + + + + - - - + + + - + + + - - - - + + + - - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - + + + - - - - + + + + - - - - + + + + - - - - + + + + - - - - + + + + - - + + + - - - - - + + + + - - - - + + + + - - + - + + - - - + + + - - - - + + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + + - + + + + + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - - + + + - - + + + + + + + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -133867,1339 +150949,1346 @@

    - - - - - - - - - - + + + - - - + + + - + - + - + - - - + + + - - - + + + + - - - - - - - - - - + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + + + - - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - - - + + + - - - - - - - - - + + - - - + + + - - + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + + - - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + + + + + + + + - - + + - - - + + + - - + + - - + + - - + + - - + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - + + - + + - - - - + + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - - + + + + - - + - - - + + + - - - + + + - - + + + - - - - + + + - - - + + + - - + + - - - + + + - - + + - - + + - + - - - - - - - - + - - + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - + + - - - + + + - - - + + + - - + + - + - + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - + + + + + + + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - - - + + + - - + + + + + + + + + + + + + + + + + - - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - + + - + + + + + + + - - + + - - - + + + @@ -135211,93 +152300,93 @@

    - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + @@ -135309,240 +152398,261 @@

    - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - + + - - - + + + - + + + + + + + + - + + + + + + + + + + + + + + + - - - + + + - - + + - - - + + + + - - + - - - + + + - - - + + + - - - + + + - - - + + + @@ -135555,196 +152665,238 @@

    - - + + - - + + - - + + - - - + + + - - + + + + + + + + + + + + + + + + - + + - - + + + + + + + - + + - + + + + + + + + - - + + - - + + - - + + - - - + + + - - + + - - + + - - - + + + + + + + + + + + + + + + + + + - - + + - - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - + + @@ -135752,854 +152904,826 @@

    - + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - - - - - - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - + + - - - - + + + + + - - - - + + - - - + + + - - - + + + - + - + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - + + - - + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - + + - - - + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - - - - - - + - - - + + + - - - + + + - - + + - - + + - - - - - - - - - - - - - - - - - + + + - - - + + + - - - + + + - - - + + + - - - - - - - - - + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - - - + + + + + + + + + + @@ -136611,1472 +153735,1500 @@

    - - - + + + - - + + + + + + + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - + - + + - - - - + + + - - - + + + - - - + + + - - + + + + + + + + + + + + + + + - + + - - + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - + - - - - + + + - - - + + + - - - + + + + - - - - - - - - - + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - + + - - - - + + + - - + + - - + + - - + + - - - + + + - - - + + + - - - + + + - + - + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + + + + + + + + - + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + + + - - - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - + + - + + - - - - + + + - - + + - - - + + + - - - + + + - - + + - + - - - + + + + + + + + + - + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + @@ -138088,695 +155240,702 @@

    - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + - - + - - - + + + - - - + + + - - + + + + + + + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - + - + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - + + - + + - - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - + + - - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - + + - - - + + + @@ -138788,674 +155947,660 @@

    - - - + + + - - - + + + - - - + + + - - - - - - - - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + + + + + + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - + - - - + + + - - - + + + + + - - - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - - - - - - - - - - - - - - - + + + - - - + + + + + - - - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - + + - - - + + + - + - + - - - + + + - - - + + + @@ -139467,893 +156612,907 @@

    - - - + + + - - - + + + - - + + - + + + + + + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - + + + + + + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + + + + + + + + + + - - - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - + + - - - + + + - - + + + + + + + + + - - + + - - - + + + - - - + + + - - - + + + - - + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - - - + + + + - - + - - - + + + - - - + + + - + - + - - - + + + - - - + + + - - + + - - - + + + - - - + + + - + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - - - - - - - - + + - - + + - - - - - - - @@ -140364,8 +157523,8 @@

    - - + + @@ -140377,9 +157536,9 @@

    + - - + @@ -140392,22 +157551,22 @@

    - - + + - + + - - + @@ -140420,8 +157579,15 @@

    - + + + + + + + + @@ -140431,18 +157597,32 @@

    + + + + + + + + + + + + + + - + - + @@ -140455,43 +157635,43 @@

    - + - + - + - + - + - + @@ -140518,22 +157698,22 @@

    - + - + - + @@ -140553,8 +157733,8 @@

    - + @@ -140567,22 +157747,22 @@

    - + - + + - @@ -140595,15 +157775,15 @@

    - + - + @@ -140616,14 +157796,14 @@

    - + - + @@ -140631,42 +157811,49 @@

    - + - - + + - - - + + + - + + + + + + + + - + - + @@ -140676,6 +157863,13 @@

    + + + + + + + @@ -140693,8 +157887,8 @@

    - + @@ -140707,8 +157901,8 @@

    - + @@ -140721,15 +157915,15 @@

    - + - + @@ -140760,7 +157954,7 @@

    Unstable Triplets - 81 + 125

    Like unstable pairs, unstable triplets require additional context to understand their @@ -140790,165 +157984,270 @@

    - - - + + + - - - + + + + + + + + + + - + - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + + + - - + + + + + + + + + + + + + + + + + + + + + + - - + + - - - + + + - + - - + + - - - + + + - - + + - - - + + + - + - - - + + + - - - + + + - - - + + + - - - + + + - - + + - - - + + + - - + + - + + + + + + + + + + + + + + + @@ -140959,283 +158258,416 @@

    - - + + - - + + - - - + + + - + + + + + + + + - - - + + + - - - + + + - + - - - + + + - - - + + + - + + + + + + + + + - - - + + - - - + + + - - + + - - + + - - - + + + - + + + + + + + + - - + + - - + + - + + + + + + + + + + + + + + + - + - - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - - - + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + + - - - + + - - - + + + - - - + + + - + - - - + + + - - - + + + + + + + + + + - - + + - + - - - + + + + + + + + + + - - + + - - - + + + - - + + - - - + + + - - - + + + - - + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -141243,6 +158675,13 @@

    + + + + + + + @@ -141252,56 +158691,84 @@

    - - - + + + - - - + + + - - - + + + - - - + + + + + + + + + + - + - - + + - - - + + + - + + + + + + + + + + + + + + + + + + + + + + @@ -141309,22 +158776,50 @@

    - - + + + + + + + + + + + + + + + + + + + + + + + - - + + - + + + + + + + + @@ -141338,14 +158833,14 @@

    - + - - + + @@ -141355,6 +158850,13 @@

    + + + + + + +
    TypeNode ANode BNode C
    Separatea(CHEBI:"amyloid-beta")bp(GO:endocytosis)path(MESH:"Alzheimer Disease")Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:choline)
    Separatep(HGNC:GSK3B)bp(GO:"apoptotic process")p(HGNC:MAPT, pmod(Ph, Ser, 396))Jensa(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))Jensa(CHEBI:heparin)a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
    Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:PICALM)
    Separatep(HGNC:CHRNA7)bp(GO:cognition)path(MESH:"Alzheimer Disease")Jensa(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:LRP1)
    Separatepath(MESH:"Alzheimer Disease")bp(GO:"neuron death")bp(MESH:Autophagy)Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HBP:"cis p-tau")
    Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"long-term synaptic potentiation")
    SeparateJens a(CHEBI:"amyloid-beta")p(HGNC:PICALM)path(MESH:"Alzheimer Disease")bp(GO:aging)p(HGNC:SYK)
    SeparateJensp(HGNC:PRKN)p(HGNC:SNCA) path(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 231))
    Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET)Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:BCL2L1)
    SeparateJenscomplex(GO:"NF-kappaB complex") path(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A)path(MESH:"Plaque, Amyloid")
    Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")Jensa(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")
    Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)path(MESH:Dementia)Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Chronic Traumatic Encephalopathy")
    Separatea(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta polypeptide 42")Jensa(CHEBI:donepezil)p(HGNC:ACHE) path(MESH:"Alzheimer Disease")
    SeparateJensa(CHEBI:"amyloid-beta")bp(GO:aging) path(MESH:"Alzheimer Disease")p(HGNC:BAG1)p(HGNC:MAPT, pmod(Ph))
    Separatepath(MESH:"Alzheimer Disease")Jensa(HBP:"Tau epitope, PHF1")p(HGNC:GSK3B) p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394))
    Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))
    Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET, frag("?"))Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:SYK)
    Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
    Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")Jensp(MGI:Rela, pmod(Ph))p(MGI:Stat3, pmod(Ph))path(MESH:Encephalomyelitis)
    Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA7)Jensa(CHEBI:"iron(0)")p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Separatep(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
    Separatep(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))Jensp(HGNC:SNCA)p(HGNC:SNCA, pmod(Ub))path(MESH:"Parkinson Disease")
    Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM1)
    Separatepath(MESH:"Alzheimer Disease")bp(GO:aging)p(HGNC:MAPT)Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:CHAT)
    Separatep(HGNC:MAPT)Jensa(CHEBI:"methylene blue")bp(GO:autophagy) p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    Separatep(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))Jensp(FPLX:NFkappaB)p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
    Mutualbp(GO:"proteasomal protein catabolic process")bp(GO:autophagy)path(MESH:"Alzheimer Disease")Jensp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")path(MESH:Glioblastoma)
    Mutualbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")Jens bp(GO:autophagy)path(MESH:"Alzheimer Disease")p(HGNC:HDAC6)p(HGNC:MAPT)
    Mutualbp(GO:aging)complex(GO:"proteasome complex")Jensa(PUBCHEM:675434)p(HGNC:MAPT) p(HGNC:MAPT)
    Mutualbp(GO:"lysosomal protein catabolic process")bp(GO:endocytosis)path(MESH:"Alzheimer Disease")Jenscomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPP2CA, pmod(Me, Leu, 309))p(HGNC:PTPA)
    Jensp(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")p(HGNC:PRNP)p(HGNC:PRNP)p(HGNC:PRNP)
    Jensa(CHEBI:"methylene blue")bp(MESH:Autophagy)a(CHEBI:"amyloid-beta")a(CHEBI:sirolimus) p(HGNC:MAPT)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:HSPA1A)bp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:APP)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
    Jensbp(GO:locomotion)composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC))complex(a(GO:microtubule), p(HGNC:MAPT)) p(HGNC:MAPT)p(HGNC:MAPT, var("?"))
    Jenscomplex(GO:"proteasome complex")p(HGNC:PRKN)p(HGNC:SNCA)a(GO:lysosome)a(HBP:"Tau aggregates")path(HBP:Neurodegeneration)
    Jensa(GO:microtubule)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jens a(HBP:"Tau aggregates")p(HBP:"Tau epitope, AT8")p(MGI:Crhr1)p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")p(HGNC:RAB5A)a(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")p(FPLX:NFkappaB)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))a(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL1B)p(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))
    Jensbp(MESH:Aging)p(FPLX:Proteasome)path(MESH:"Protein Aggregation, Pathological")a(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")path(MESH:"Alzheimer Disease")
    Jensa(MESH:"Cholinergic Neurons")p(HGNC:APP)p(HGNC:BACE1) path(MESH:"Alzheimer Disease")path(MESH:Apathy)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")path(MESH:"Diabetes Mellitus")p(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:memory)a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")p(HGNC:CHRNA7)
    Jensa(CHEBI:"okadaic acid") complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensp(HGNC:APP, frag("672_713"))p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(FPLX:CHRN)bp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 321))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:Microglia)
    Jensbp(GO:"microtubule polymerization")p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:D002800)
    Jens a(CHEBI:"amyloid-beta")bp(GO:autophagy)complex(GO:"inflammasome complex")bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")
    Jensa(CHEBI:"okadaic acid")bp(GO:cognition)p(HGNC:MAPT, pmod(Ph))a(HBP:HBP00074)bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
    Jensbp(GO:mitophagy)p(HGNC:PRKN)p(HGNC:PRKN, var("?"))a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)
    Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1)a(CHEBI:"amyloid-beta")p(HGNC:ABCB1) path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)p(HGNC:APP)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") p(HGNC:MAPT)p(HGNC:SQSTM1)
    Jensa(CHEBI:rolipram)complex(GO:"proteasome complex")p(FPLX:PKA)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(HBP:"Tau epitope, PHF1")
    Jensa(CHEBI:"3',5'-cyclic AMP")a(CHEBI:rolipram)bp(GO:"microtubule polymerization")complex(GO:microtubule) p(HGNC:MAPT)
    Jensa(CHEBI:heparin)a(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))a(HBP:HBP00018)a(HBP:HBP00030)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(HP:"interstitial fluid")bp(GO:aging)complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
    Jensa(CHEBI:galanthamine)p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:chloroquine)p(HGNC:MAPT)p(HGNC:SQSTM1)a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")p(HGNC:SYK)
    Jensp(HGNC:HSF1)p(HGNC:HSF1)p(HGNC:HSF1)a(CHEBI:bortezomib)p(FPLX:PPP2C)p(HGNC:CIP2A)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)p(FPLX:AMPK)a(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:CHRNA7)
    Jensa(GO:lysosome)a(GO:lysosome)a(GO:lysosome)p(HGNC:CDK1)p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HBP:"Tau C3")
    Jensa(HBP:"Tau aggregates")bp(GO:aging)p(HGNC:SYK)a(CHEBI:"amyloid-beta")bp(GO:autophagy)complex(GO:"inflammasome complex")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:memory)a(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
    Jensa(PUBCHEM:675434)a(MESH:Brain) p(HGNC:MAPT)p(HGNC:USP14)path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"neuron projection")complex(GO:axon) p(HGNC:MAPT) p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:pioglitazone)bp(GO:memory)bp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)
    Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00018)p(HGNC:IDE)a(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine)bp(GO:"MAPK cascade") p(HBP:"alpha-4 beta-2 nAChR")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")bp(GO:memory)p(HGNC:APP)p(HGNC:WNT3A)
    Jensa(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:CDK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine) p(HGNC:ACHE)
    Jensp(HGNC:CAPN2)p(HGNC:CAST)p(HGNC:HTT, var("?"))a(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:SET)a(CHEBI:"amyloid-beta")p(HGNC:MARK4) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 396))complex(GO:"proteasome complex")p(HGNC:MAPT)p(HGNC:SQSTM1)
    Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:"Diabetes Mellitus")a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:phagocytosis)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:SYK)a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:HSPA1A)
    Jensa(HBP:HBP00074)p(HGNC:NGFR)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease")
    Jensbp(MESH:Aging)p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(HBP:HBP00018)p(HGNC:IDE)
    Jensp(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)
    Jensa(CHEBI:lactacystin)p(FPLX:Proteasome) p(HGNC:MAPT)p(HGNC:TGM2)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK1)p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")a(CHEBI:"nitric oxide")a(CHEBI:peroxynitrite)complex(GO:"NF-kappaB complex")
    Jensp(HGNC:NGFR)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensbp(MESH:Aging)p(FPLX:HSP90)p(HGNC:PTGES3)a(CHEBI:"advanced glycation end-product")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(FPLX:CHRN)a(HBP:"Tau oligomers")complex(GO:axon)p(HGNC:MAPT)
    Jensa(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:IL1B)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")path(MESH:"Diabetes Mellitus")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:ACE)a(CHEBI:rivastigmine)bp(GO:cognition) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)path(HBP:neurotoxicity)bp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))a(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A)path(MESH:"Alzheimer Disease")a(GO:"neurofibrillary tangle")bp(GO:"apoptotic process")p(HGNC:NFKB1)
    Jensa(CHEBI:dextran)a(CHEBI:dextran)a(CHEBI:dextran)a(CHEBI:"amyloid-beta")bp(GO:memory)p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:APP)a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(OGlyco))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:acetylcholine) a(CHEBI:acetylcholine)a(CHEBI:choline)p(HGNC:CHRM1)
    Jensp(HGNC:MAPT, pmod(NGlyco))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")bp(MESH:Neuroprotection)complex(GO:"NF-kappaB complex")
    Jensa(CHEBI:donepezil)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")complex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:GSK3B)p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")bp(GO:memory)g(HGNC:NLRP3)
    Jensa(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)p(FPLX:JNK)p(HGNC:AGER)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(GO:synapse)path(MESH:"Plaque, Amyloid")a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HBP:"alpha-4 beta-2 nAChR")complex(p(HGNC:APP), p(HGNC:HSD17B10))p(HGNC:HSD17B10)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")a(GO:lysosome) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"methylene blue")bp(GO:autophagy)p(HGNC:MAPT)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
    Jensbp(GO:macroautophagy)p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")a(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:SQSTM1)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(HBP:"Tau epitope, PHF1")a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)complex(GO:"NF-kappaB complex")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:DKK1)p(HGNC:WNT3A)a(GO:presynapse)a(PUBCHEM:64627)p(MGI:Adora1)
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))p(HGNC:BACE1)p(HGNC:NGFR) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")a(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 202))a(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")
    Jensa(CHEBI:ambroxol)bp(GO:macroautophagy)p(HGNC:SNCA)a(CHEBI:"amyloid-beta")p(HGNC:IDE)path(MESH:"Alzheimer Disease")
    Jensp(MGI:Rela, pmod(Ph))p(MGI:Stat3, pmod(Ph))path(MESH:Encephalomyelitis)bp(GO:"neuron death")p(HGNC:CASP3)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:wogonin)bp(GO:autophagy)bp(GO:aging)p(HGNC:FKBP5)p(HGNC:MAPT)
    Jensa(HBP:"Tau aggregates")bp(GO:"axonal transport")path(HBP:Neurodegeneration)a(CHEBI:"trichostatin A")p(FPLX:HDAC)p(HGNC:MAPT, pmod(Ac))
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")bp(GO:"apoptotic process")bp(MESH:"Oxidative Stress")p(HGNC:GSK3B)
    Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)a(MESH:"Neurofibrillary Tangles") p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensp(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:memory)
    Jensa(HBP:HBP00018)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")bp(MESH:Aging)p(FPLX:Proteasome)path(MESH:"Protein Aggregation, Pathological")
    Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)a(CHEBI:"amyloid-beta")a(GO:synapse)path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"amyloid-beta") a(CHEBI:acetylcholine)a(CHEBI:nicotine) p(HGNC:CHRNA7)
    Jensp(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:STUB1)a(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL18)
    Jensa(CHEBI:chloroquine)p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:ABCB1)
    Jenscomplex(GO:axon)p(HGNC:MAPT)a(CHEBI:chloroquine) p(HGNC:MAPT)p(HGNC:SQSTM1)
    Jensa(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(GO:"neurofibrillary tangle")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))p(MGI:Mapt)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(HBP:"Corticobasal Degeneration")a(CHEBI:acetylcholine)a(CHEBI:galanthamine)p(HGNC:ACHE)
    Jensbp(GO:"neuron death")complex(GO:"protein phosphatase type 2A complex")a(CHEBI:"amyloid-beta")p(HGNC:NGFR) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:tanespimycin)bp(GO:memory)a(CHEBI:"calcium(2+)")p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)
    Jensa(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta")bp(GO:macroautophagy)a(MESH:Proteins)bp(GO:endocytosis)p(HGNC:RAB5A)
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")a(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(GO:macroautophagy)
    Jens a(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:DKK1)bp(GO:"response to oxidative stress")bp(GO:autophagy)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"cell death")p(HGNC:CHRNA7)a(HBP:HBP00018)p(HGNC:IDE)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jens a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL1B)a(CHEBI:rivastigmine)p(HGNC:LRP1)
    Jenscomplex(p(HGNC:APP), p(HGNC:HSD17B10))p(HGNC:HSD17B10)path(MESH:"Alzheimer Disease")a(MESH:Hippocampus)p(HGNC:CHRNA7)path(MESH:Schizophrenia)
    Jensp(HGNC:BAG1)p(HGNC:MAPT)bp(GO:"MAPK cascade")p(HGNC:TNF) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)complex(GO:"NF-kappaB complex")p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
    Jensbp(GO:"neuron death")p(HGNC:BACE1)p(HGNC:IL1B) path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jens a(CHEBI:nicotine)a(HBP:"Tau aggregates")path(HBP:neurotoxicity)bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
    Jensbp(GO:cognition)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")bp(GO:autophagy)a(CHEBI:"okadaic acid")p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)
    Jensp(HGNC:DAPK1)p(HGNC:BAG1)p(HGNC:MAPT) p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM2)a(CHEBI:geldanamycin)p(FPLX:HSP90)p(HGNC:HSF1)
    Jensp(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:aging)
    Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))a(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)path(HBP:neurotoxicity)
    Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:PPP5C)path(MESH:"Alzheimer Disease")a(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK6)
    Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))a(GO:mitochondrion)bp(MESH:"Oxidative Stress")p(HGNC:GLP1R)
    Jensa(HBP:"granulovacuolar degeneration")p(HGNC:MAPT, pmod(Ph, Ser, 262))p(HGNC:MARK4, pmod(Ph))a(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))bp(GO:memory)p(HGNC:BACE1)p(HGNC:UCHL1)
    Jensbp(GO:aging)p(HGNC:IL18)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jensg(HBP:"APOE e4")p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:APP)a(CHEBI:epoxomicin)p(HGNC:CASP3)p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine) bp(GO:memory)p(HGNC:CHRNA7)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"phosphatase-activating domain")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HBP:"Tau aggregates")a(MESH:Astrocytes)p(HGNC:APP)p(HGNC:IL1B)
    Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)a(GO:presynapse)a(HBP:"Tau aggregates")a(MESH:"BSc 3094")
    Jensbp(HBP:"protein aggregation")complex(p(HGNC:BAG6), p(HGNC:UBA3))p(MESH:Proteins, pmod(HBP:misfolding))a(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:IL1B)
    Jensa(HBP:"protein aggregates")bp(GO:autophagy)path(MESH:"Amyotrophic Lateral Sclerosis")a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(HBP:HBP00074)p(HGNC:NGFR)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")
    Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:TREM2, var("p.Arg47His"))bp(MESH:Aging)p(FPLX:HSP90)path(MESH:"Protein Aggregation, Pathological")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))a(CHEBI:donepezil)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
    Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:memory)
    Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:SQSTM1)a(CHEBI:acetylcholine)a(CHEBI:galanthamine)path(MESH:"Alzheimer Disease")
    Jensa(HBP:HBP00006)p(HBP:HBP00053, var("p.Lys280del"))p(HGNC:MAPT)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:MMP2)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
    Jensp(FPLX:GSK3)a(CHEBI:"okadaic acid")bp(GO:cognition) p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Syk)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(GO:aging)complex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates") a(MESH:Trehalose) bp(MESH:Autophagy)p(HGNC:MAPT)
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Supranuclear Palsy, Progressive")p(HBP:"CDK5R1 p25")p(HBP:"Tau epitope, AT8")p(MGI:Cdk5)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")p(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:Temsirolimus)bp(GO:autophagy)complex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))p(HGNC:MAPT, pmod(Ph))
    Jensbp(GO:"axonal transport") p(HGNC:MAPT)p(HGNC:NPEPPS)path(MESH:"Frontotemporal Dementia")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensp(HGNC:MAPT)p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")a(CHEBI:Temsirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
    Jensa(CHEBI:sirolimus)bp(GO:macroautophagy)p(HGNC:SNCA)a(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:ABCB1)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers") bp(MESH:Autophagy)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")p(HGNC:IL1B) path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensbp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:MAPT)a(PUBCHEM:164676)p(FPLX:IKB)p(FPLX:NFkappaB)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BCL2)bp(GO:learning)complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM1)p(HGNC:IL18)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:ACHE)a(HBP:HBP00093)bp(GO:autophagy)p(HGNC:TFEB)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ph))bp(GO:aging)p(HGNC:FKBP5) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    Jensp(HGNC:CASP3)a(CHEBI:"amyloid-beta") p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)bp(MESH:Aging)p(FPLX:HSP90)p(HGNC:SYK)
    Jens a(CHEBI:"amyloid-beta")bp(GO:"response to oxidative stress")bp(GO:autophagy)a(CHEBI:"amyloid-beta")complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
    Jenscomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:HSPB1)bp(GO:autophagy) p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensbp(GO:locomotion)composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14))p(HGNC:MAPT)a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)p(FPLX:AMPK)
    Jens a(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)bp(GO:endocytosis)g(HBP:"APOE e4")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:APOE)p(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(GO:endocytosis)g(HBP:"APOE e4")p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
    Jensa(HBP:"Tau aggregates")bp(GO:aging)p(HGNC:MAPT)a(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")p(FPLX:TLR)a(MESH:Kidney)
    Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:BACE1)p(HGNC:RELA) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(MGI:Crhr1)a(HBP:"amyloid-beta aggregates")path(HBP:"mitochondrial dysfunction")path(MESH:"Alzheimer Disease")
    Jensp(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")a(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:BCL2L1)
    Jens a(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)bp(GO:"long-term synaptic potentiation")p(HGNC:RELA)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:nicotine)p(HGNC:TNF)bp(GO:"neuron death")
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("?"))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
    Jensbp(GO:"microtubule polymerization")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(HBP:"Tau oligomers")bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:metformin)bp(GO:autophagy)p(FPLX:PKA)p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:SYK)
    Jensbp(GO:autophagy)a(CHEBI:"dimethyl fumarate")p(FPLX:ERK) p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HBP:"alpha-4 beta-2 nAChR")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")
    Jensa(CHEBI:"alpha,alpha-trehalose")a(HBP:"Tau aggregates")bp(GO:macroautophagy)a(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))
    Jensa(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)p(HGNC:MAPT)a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Asn279Lys"))
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:endocytosis)complex(GO:"NF-kappaB complex")p(HGNC:IL6)
    Jensbp(GO:"neuron death")p(HGNC:MMP2)a(CHEBI:"amyloid-beta")p(HGNC:CHRNA3) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:sirolimus)p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))
    Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau fibrils")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))a(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")p(HGNC:MAPT)
    Jenscomplex(GO:"filamentous actin")p(HGNC:MAPT)a(CHEBI:"alpha,alpha-trehalose")p(HGNC:BAG3) p(HGNC:MAPT)
    Jenscomplex(a(GO:"proteasome complex"), p(HGNC:PRKN))p(HGNC:PRKN, var("p.Arg42"))path(MESH:"Parkinsonian Disorders")a(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jens a(CHEBI:"amyloid-beta")a(MESH:Astrocytes)p(HGNC:IL1B)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:donepezil)p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL18)complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
    Jensa(HBP:HBP00074)bp(GO:aging)path(MESH:"Alzheimer Disease")complex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))p(HGNC:MAPT, pmod(Ph))
    Jensbp(GO:cognition)p(HGNC:FYN)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:CHRM1)
    Jensa(MESH:Trehalose)bp(MESH:Autophagy)p(HGNC:MAPT)a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")
    Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:NFkappaB)
    Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)p(FPLX:PPP2)p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))bp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:SIRT1)
    Jensbp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))bp(GO:"anterograde axonal protein transport")p(HBP:"6D tau", frag("2_18"))p(MESH:"Glycogen Synthase Kinase 3")
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(HBP:"phosphatase-activating domain")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")p(HGNC:BAG1)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"okadaic acid")p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)a(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:IL1B)
    Jensa(HBP:"Tau aggregates")a(MESH:Autophagosomes)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
    Jensbp(GO:"chaperone-mediated autophagy")bp(MESH:Aging)path(MESH:"Protein Aggregation, Pathological")p(HGNC:MAPT)p(HGNC:MAPT, frag("?"))path(HBP:Neurodegeneration)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"inflammatory response")p(HGNC:DKK1)p(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:sirolimus) bp(GO:autophagy)p(HGNC:APP)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")path(HBP:neurotoxicity)bp(GO:"clathrin-dependent endocytosis")p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic")p(HGNC:CHRNA7)bp(MESH:Aging)bp(MESH:Proteolysis)p(FPLX:HSP90)
    Jensbp(GO:aging)p(HGNC:IL1B)p(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Chrna7)
    Jensp(HGNC:CHRNA4)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers") a(MESH:Neurons) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(MESH:Lysosomes)bp(MESH:Proteolysis)path(MESH:"Alzheimer Disease")p(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))
    Jensp(HGNC:CAPN1)p(HGNC:CAST)p(HGNC:HTT, var("?"))a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))
    Jensbp(GO:macroautophagy)p(HGNC:MAPT, var("p.Ala152Thr"))p(MGI:Mapt)a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Val337Met"))
    Jens a(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:BCL2)a(CHEBI:nicotine)p(HGNC:BAX)
    Jensa(CHEBI:nicotine)a(MESH:"SNARE Proteins")p(HGNC:CHRNA7)a(HBP:"Tau aggregates")bp(GO:aging)p(HGNC:SYK)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:AQP4)a(MESH:Nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)path(MESH:"Alzheimer Disease")a(CHEBI:scopolamine)a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid")bp(GO:"behavioral fear response")
    Jensa(MESH:"Amyloid beta-Peptides")p(HGNC:APP)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)bp(GO:autophagy)
    Jensbp(GO:"axonal transport")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)p(FPLX:NFkappaB)p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")a(CHEBI:metformin)bp(GO:autophagy)
    Jensbp(GO:"neuron death")p(HGNC:CASP3)a(HBP:"Tau oligomers")a(HBP:"Tau oligomers") path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BCL2)
    Jensa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:SYK)p(FPLX:NFkappaB)p(HGNC:IL18)path(MESH:"Alzheimer Disease")
    Jensp(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))a(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))
    Jensp(HGNC:IL18)p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 396)) path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jensa(CHEBI:"amyloid-beta")bp(GO:memory)complex(GO:"NF-kappaB complex")
    Jens a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")bp(MESH:Neuroprotection)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:"Cholinesterase Inhibitors")a(CHEBI:"methylene blue")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
    Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:IL6)
    Jensa(CHEBI:Thrombin)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:IL1B)
    Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")p(FPLX:CHRN)a(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CHRNA4)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(MESH:"Amyloid beta-Peptides")p(HGNC:BECN1) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:rolipram)a(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199))
    Jensp(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:GSK3B)p(HGNC:GSK3B, pmod(Ph, Ser, 9))p(HGNC:PPP1CA)
    Jensa(HBP:"amyloid-beta oligomers")a(CHEBI:rolipram)complex(GO:"proteasome complex") p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK4)a(PUBCHEM:675434)p(HGNC:MAPT)p(HGNC:USP14)
    Jensa(MESH:Proteins)a(MESH:Proteins)bp(GO:endocytosis)a(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensp(FPLX:CALM)p(HBP:"DAPK, basic loop (BL) motif")p(HGNC:DAPK2)a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Jensa(CHEBI:"alpha,alpha-trehalose")p(HGNC:BAG3)p(HGNC:MAPT)a(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:CCL2)
    Jenscomplex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:SYK)a(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:CHRM1)
    Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, var("?"))a(CHEBI:acetylcholine)a(MESH:"Cholinergic Neurons")bp(GO:memory)
    Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensp(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")a(CHEBI:cilostazol)bp(GO:macroautophagy)p(FPLX:mTORC1)
    Jensp(HGNC:HMOX1)p(HGNC:NFE2L2)path(MESH:"Alzheimer Disease")a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:CHRM1)bp(GO:aging)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(HBP:HBP00074)p(HGNC:NGFR)path(MESH:"Cognitive Dysfunction")p(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")bp(GO:proteolysis)a(CHEBI:dopamine)a(HBP:HBP00093)path(MESH:"Parkinson Disease")
    Jensa(PUBCHEM:377503130)p(FPLX:"CCT_complex")p(HGNC:HSF1)a(CHEBI:"amyloid-beta")a(CHEBI:tanespimycin)bp(GO:memory)
    Jensa(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade") bp(GO:"apoptotic process")p(HGNC:CDK5)p(HGNC:MAPK1)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:ABCB1)a(MESH:"Cholinergic Neurons")path(MESH:"Alzheimer Disease")path(MESH:Apathy)
    Jensa(GO:"neurofibrillary tangle")p(HGNC:CDKN2A)path(MESH:"Alzheimer Disease")a(MESH:"Amyloid beta-Peptides")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Jensa(CHEBI:staurosporine)bp(GO:"apoptotic process")p(HGNC:CDK5)a(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))p(HGNC:TNF)
    Jensp(HGNC:BAG1)p(HGNC:MAPT)bp(GO:"proteasomal protein catabolic process")p(HGNC:HSPB1) p(HGNC:MAPT)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:"Alzheimer Disease")bp(GO:memory)complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Jens a(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13")path(MESH:"Alzheimer Disease")p(HGNC:CDKN2A)path(MESH:"Supranuclear Palsy, Progressive")
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:FYN)p(HGNC:MAPT, pmod(Ph, Tyr, 18))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:PI3K)a(HBP:"Tau aggregates")bp(GO:aging)path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL1B)a(PUBCHEM:155160)bp(GO:memory)p(HGNC:BACE1)
    Jensa(HBP:"amyloid-beta aggregates")p(HGNC:APP, var("?"))path(MESH:"Alzheimer Disease")a(PUBCHEM:675434)p(FPLX:Proteasome)p(HGNC:USP14)
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")bp(HBP:neurotoxicity)a(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta")bp(GO:macroautophagy)
    Jensbp(GO:"long-term synaptic potentiation")a(CHEBI:wortmannin)bp(GO:autophagy) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")path(HBP:Neurodegeneration)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(NGlyco))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:memory)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:BIN1)a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")bp(HBP:neurotoxicity)
    Jensp(HGNC:FKBP5) p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensp(HGNC:CDK5)p(HGNC:IL18) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"Hsp90 inhibitor")a(HBP:"Tau aggregates")bp(GO:aging)p(HGNC:MAPT)
    Jenscomplex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL18)
    Jenscomplex(GO:"filamentous actin") p(HGNC:MAPT) p(HGNC:MAPT)
    Jensp(HGNC:MAPT, frag("?"))p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")a(MESH:D002800)bp(GO:"GO:0014047")path(MESH:D000544)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)path(MESH:"Alzheimer Disease")bp(MESH:"Neuronal Outgrowth")complex(GO:"NF-kappaB complex")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")path(MESH:"Alzheimer Disease")a(CHEBI:"potassium(1+)")p(HGNC:IL1B)p(HGNC:PYCARD)
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(GO:lysosome)complex(GO:"NLRP3 inflammasome complex")a(CHEBI:rosiglitazone)
    Jensp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")p(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jensbp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:TFEB)a(CHEBI:"okadaic acid")p(FPLX:PPP2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:Anxiety)
    Jensa(CHEBI:scopolamine)a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid")bp(GO:"behavioral fear response")a(GO:"neurofibrillary tangle")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")p(MGI:Chrna7)p(HGNC:AGER)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:HMOX1)p(HGNC:NFE2L2) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:autophagy)p(HGNC:MAPT) path(HBP:neurotoxicity)
    Jensa(CHEBI:cilostazol)bp(GO:macroautophagy)p(FPLX:mTORC1)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jensbp(GO:"microglial cell activation")p(HGNC:IL18)a(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Thr, 181))
    Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")
    Jensp(FPLX:ERK)p(FPLX:NFkappaB) path(MESH:"Alzheimer Disease")
    Jensbp(MESH:Neuroprotection)a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade") p(HGNC:CHRNA7)p(HGNC:JAK2)
    Jensa(HBP:"Tau aggregates")p(HGNC:CTSD)p(HGNC:MAPT)path(HBP:neurotoxicity)
    Jens complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))
    Jensa(CHEBI:nicotine) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
    Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jens a(CHEBI:"amyloid-beta")a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one")p(HGNC:CHRM1)a(CHEBI:Temsirolimus)bp(GO:autophagy)
    Jensp(HGNC:HDAC6)p(HGNC:MAPT)a(GO:microtubule)bp(GO:"anterograde axonal transport") p(HGNC:MAPT)
    Jensbp(GO:aging)p(HGNC:FKBP5)a(HBP:"amyloid-beta oligomers") p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))p(HGNC:CAPN1)p(HGNC:CAST)p(HGNC:HTT, var("?"))
    Jensa(CHEBI:curcumin)bp(GO:macroautophagy)bp(GO:autophagy) p(FPLX:mTORC1)p(HGNC:TFEB)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))p(HGNC:MAPT)p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta")bp(GO:autophagy)complex(GO:"NF-kappaB complex")p(HGNC:BACE1)p(HGNC:TNF)
    Jensa(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13")path(MESH:"Supranuclear Palsy, Progressive")
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(HBP:neuroinflammation)
    Jens a(CHEBI:"amyloid-beta")bp(GO:endocytosis) p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
    Jensa(GO:lysosome)bp(GO:"long-term synaptic potentiation")p(HGNC:MAPT) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:CHRNA4)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 181))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(MESH:Autophagosomes)a(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, var("p.Ala152Thr"))
    Jens a(CHEBI:"amyloid-beta")a(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)bp(GO:autophagy)p(HGNC:BIN1)
    Jensa(CHEBI:"calcium(2+)")bp(MESH:"Oxidative Stress")p(HGNC:S100B)bp(GO:memory)complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT, pmod(Ph, Ser, 262))p(INTERPRO:"Kinase associated domain 1 (KA1)")bp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:MAPT)
    Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))bp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:TFEB)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(OGlyco))p(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:galanthamine)p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
    Jensa(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(HBP:"Tau aggregates")p(HGNC:MAPT)p(HGNC:SYK)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:acetylcholine)p(HGNC:BCHE) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202))bp(GO:cognition)p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
    Jens a(HBP:"Tau aggregates") a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))p(MGI:Crhr1)
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")p(HGNC:BCL2)p(HGNC:TNF)
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")bp(HBP:Excitotoxicity)a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:"positive regulation of advanced glycation end-product receptor activity")
    Jensa(CHEBI:galanthamine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)a(CHEBI:"glutamate(1-)")a(GO:"excitatory synapse")complex(GO:"NF-kappaB complex")
    Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")a(MESH:Morphine)p(FPLX:IKB)p(FPLX:NFkappaB)
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(HBP:Neurodegeneration)a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
    Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Supranuclear Palsy, Progressive")
    Jensbp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(HBP:neurotoxicity)
    Jensa(CHEBI:dopamine)a(CHEBI:"amyloid-beta") a(CHEBI:nicotine) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")complex(p(HGNC:MAPT), p(HGNC:TGM2))
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:aging)bp(GO:"lysosomal protein catabolic process")bp(GO:memory)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")g(HBP:"APOE e4")p(HGNC:APP)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:SYK)a(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic")p(HGNC:CHRNA7)
    Jensa(HBP:"Tau oligomers")bp(GO:"long-term synaptic potentiation")p(HGNC:MAPT)a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")bp(GO:learning)p(MGI:App, frag("25_35"))
    Jensa(CHEBI:acetylcholine)a(MESH:"Cholinergic Neurons")bp(GO:memory)bp(GO:"neuron death")p(HGNC:MMP2)path(MESH:"Alzheimer Disease")
    Jensp(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:PTGES3)p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"oncostatin M")path(MESH:Glioblastoma)
    Jensa(CHEBI:wogonin)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:epoxomicin)p(HGNC:CASP3)p(HGNC:MAPT)a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Pick Disease of the Brain")
    Jens a(CHEBI:"amyloid-beta")p(FPLX:ERK)path(MESH:"Alzheimer Disease")a(MESH:Microglia)bp(GO:phagocytosis)
    Jensp(HGNC:MAPT, pmod(Ub))bp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
    Jensp(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
    Jensbp(GO:"long-term synaptic potentiation")p(HGNC:HSPB1) p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:TFEB)p(HGNC:CHRM1)p(HGNC:MAPT, pmod(Ph))
    Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ub))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)bp(GO:"autophagosome assembly")
    Jensp(HGNC:CDC37)complex(GO:"protein phosphatase type 2A complex") p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jenscomplex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:GSK3B)p(HGNC:MAPT)a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:SYK)
    Jensp(HGNC:ABL1)p(HGNC:MAPT, pmod(Ph, Tyr, 394))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:DKK1)
    Jensa(CHEBI:rivastigmine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")a(HBP:"amyloid-beta oligomers")p(HGNC:MAPT, pmod(Ph, Ser, 356))p(INTERPRO:"Kinase associated domain 1 (KA1)")
    Jensbp(GO:autophagy)p(HGNC:CAPN1)p(HGNC:CAST)a(CHEBI:"potassium(1+)")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
    Jensa(HBP:"amyloid-beta aggregates")p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:rolipram)p(HGNC:MAPT)p(HGNC:MAPT)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Bace1)a(CHEBI:nicotine)bp(GO:"MAPK cascade")p(FPLX:NFkappaB)
    Jensbp(MESH:Aging)p(HGNC:PTGES3)path(MESH:"Protein Aggregation, Pathological")a(HBP:"Tau aggregates")bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN2)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")
    Jensa(CHEBI:sirolimus)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")bp(GO:mitophagy)p(HGNC:PRKN)p(HGNC:PRKN, var("?"))
    Jensa(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:AGER)complex(GO:"NF-kappaB complex")p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Jensa(HBP:HBP00074)a(HBP:"Tau aggregates")p(HGNC:MAPT) path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jensbp(MESH:Autophagy)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(CHEBI:ambroxol)bp(GO:macroautophagy)p(HGNC:SNCA)
    Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT)bp(GO:macroautophagy)p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")bp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)a(CHEBI:Temsirolimus)bp(GO:macroautophagy)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:AK1)p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:ITPKB)a(CHEBI:"amyloid-beta")p(HGNC:APOE) path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199))a(CHEBI:"methylene blue")bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
    Jensa(HBP:"amyloid-beta aggregates")path(HBP:"mitochondrial dysfunction")path(MESH:"Alzheimer Disease")bp(GO:cognition)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Lys280del"))
    Jensa(CHEBI:acetylcholine)p(HGNC:BCHE)path(MESH:"Alzheimer Disease")bp(GO:locomotion)p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))
    Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")bp(GO:endocytosis)g(HBP:"APOE e4")
    Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))a(CHEBI:chloroquine)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HBP:"cis p-tau")a(CHEBI:acrolein)a(GO:"neurofibrillary tangle")path(MESH:"Alzheimer Disease")
    Jensbp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:RAB5A)complex(GO:"NF-kappaB complex")p(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)p(HGNC:CHRNA7)bp(GO:"MAPK cascade")p(FPLX:NFkappaB)p(HGNC:TNF)
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:CHRM1)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"apoptotic process")
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(CHEBI:donepezil) p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 202))bp(GO:"microglial cell activation")p(HGNC:IL18) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:wortmannin)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph, Ser, 262))a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:"Diabetes Mellitus")
    Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(GO:"neurofibrillary tangle")p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:rivastigmine)bp(GO:cognition)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:DKK1)p(HGNC:WNT3A)
    Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))a(CHEBI:resveratrol)p(HGNC:MID1)p(HGNC:PPP2CA)
    Jensa(CHEBI:cilostazol)bp(GO:macroautophagy)p(HGNC:MAPT, pmod(HBP:HBP00007))a(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)
    Jensa(CHEBI:donepezil)p(HGNC:LRP1)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)p(FPLX:mTORC1)p(HGNC:TFEB)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph))p(HGNC:TREM2)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:"Cholinesterase Inhibitors")
    Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))complex(GO:"NF-kappaB complex")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:epoxomicin)p(HGNC:MAPT)p(HGNC:MAPT)bp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))path(MESH:"Proteostasis Deficiencies")
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensbp(MESH:Aging)p(FPLX:HSPA)path(MESH:"Protein Aggregation, Pathological")bp(GO:autophagy)p(HGNC:HSPB1)p(HGNC:MAPT, pmod(Ph))
    Jensp(HGNC:CDC37) p(HGNC:CDK5)p(HGNC:MAPK1)path(MESH:"Alzheimer Disease")p(HGNC:MAPT, pmod(Ph, Thr, 231))
    Jensa(GO:"neurofibrillary tangle")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL18)
    Jensbp(GO:"microglial cell activation")p(HGNC:NR1H3)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:SYK)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)p(MESH:Neprilysin)path(MESH:"Alzheimer Disease")
    Jensa(PUBCHEM:675434)p(FPLX:Proteasome)p(HGNC:USP14)a(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:ABCB1)p(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Corticobasal Degeneration")p(HGNC:MAPT)p(HGNC:MAPT)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")a(CHEBI:rolipram)a(HBP:"Tau aggregates") p(HGNC:MAPT)p(HGNC:SQSTM1)
    Jens bp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Ala152Thr"))complex(GO:"NF-kappaB complex")p(HGNC:CXCL8)
    Jensa(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")p(HGNC:MAPT, frag("?"))a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:APOE)
    Jens a(CHEBI:"amyloid-beta")bp(GO:"cerebrospinal fluid circulation")bp(GO:aging)a(CHEBI:"amyloid-beta")p(HGNC:AQP4)
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)a(CHEBI:"amyloid-beta")p(HGNC:BIN1)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:FYN)a(CHEBI:"amyloid-beta")p(HGNC:SYK)
    Jensa(GO:"neurofibrillary tangle")p(HGNC:TGM2)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205)) path(MESH:"Alzheimer Disease")
    Jensbp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
    Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(MESH:Neurons)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph))p(HGNC:TREM2)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:ABCB1)
    Jensbp(GO:autophagy)p(HGNC:HDAC6)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")bp(GO:"neuron death")p(HGNC:RAB5A)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)a(CHEBI:cholesterol)bp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Niemann-Pick Diseases")a(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:IDE)p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:OTUB1)
    Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:cognition)complex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:NGFR)path(MESH:"Alzheimer Disease")bp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))
    Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 396))a(CHEBI:galanthamine)p(HGNC:HMOX1) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)a(HBP:HBP00093)bp(GO:autophagy)p(HGNC:HDAC6)
    Jens a(CHEBI:dopamine) a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Jenscomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPP2CA, pmod(Me, Leu, 309))p(HGNC:PTPA)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensp(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))a(HBP:HBP00074)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
    Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))a(CHEBI:"amyloid-beta")bp(GO:"inflammatory response")p(HGNC:DKK1)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP9)bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CDK5) p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Jensa(GO:mitochondrion)bp(MESH:"Oxidative Stress")p(HGNC:GLP1R)
    Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensbp(GO:endocytosis)g(HBP:"APOE e4")p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")bp(GO:"MAPK cascade")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:MAPT)bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(CHEBI:"alpha,alpha-trehalose")a(HBP:"Tau aggregates")bp(GO:macroautophagy)
    Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:IL18)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jens a(CHEBI:"amyloid-beta")bp(GO:"lysosomal microautophagy")complex(GO:"TOR complex")
    Jensa(CHEBI:"D-ribose")a(CHEBI:"advanced glycation end-product")p(MGI:Mapt, pmod(Ph, Ser, 396))a(CHEBI:"amyloid-beta")p(HGNC:IDE)
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:BACE1)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:ABCB1)a(MESH:"Amyloid beta-Peptides")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:rolipram)a(HBP:"Tau aggregates")bp(GO:locomotion)composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:ZC3H14)) p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:HSPB1)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")p(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202))
    Jensp(HGNC:DAPK1)p(HGNC:MAPT)p(HGNC:MAPT)a(PUBCHEM:71361092)p(FPLX:PPP2)path(MESH:Neoplasms)
    Jensa(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13")path(MESH:"Supranuclear Palsy, Progressive")a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRN)
    Jensa(CHEBI:"Hsp90 inhibitor")a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal")p(HGNC:MAPT)a(CHEBI:heparin)a(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))
    Jensa(MESH:Astrocytes)p(HGNC:APP)p(HGNC:IL1B)p(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:donepezil)p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
    Jens a(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process") bp(GO:autophagy)path(HBP:neurotoxicity)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")p(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Arg406Trp"))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)a(CHEBI:Calpeptin)p(HGNC:CAPN2)p(HGNC:HTT, var("?"))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)a(CHEBI:memantine)bp(GO:cognition)path(MESH:"Alzheimer Disease")
    Jensbp(GO:cognition)p(HGNC:CHRNA7) p(HGNC:CHRNA7)
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(HBP:"phosphatase-activating domain")p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))path(MESH:"Alcohol Drinking")r(HGNC:ADNP)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:WNT3A)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:BCHE)
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 231))a(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")path(MESH:"Alzheimer Disease")
    Jensp(HGNC:PRNP)p(HGNC:PRNP)p(HGNC:PRNP)p(HGNC:MAPT, pmod(NGlyco))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"apoptotic process")a(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")bp(HBP:Excitotoxicity)
    Jens a(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:memory)a(CHEBI:rosiglitazone)a(HBP:HBP00018)
    Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(GO:lysosome)bp(GO:endocytosis)
    Jensa(GO:lysosome)a(HBP:"Tau aggregates")bp(GO:"MAPK cascade")p(HGNC:AGER) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")bp(MESH:Neuroprotection)a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:cognition)path(MESH:"Alzheimer Disease")
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")p(HGNC:APP)
    Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(FPLX:mTORC1)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 404))bp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
    Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 396))p(HGNC:CHAT) path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Asn279Lys"))a(CHEBI:"amyloid-beta")p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")
    Jensbp(GO:macroautophagy)p(FPLX:AMPK)p(FPLX:mTORC1)p(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(GO:lysosome)bp(GO:macroautophagy) p(HGNC:TFEB)
    Jensa(CHEBI:acrolein)complex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:FYN) path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(MESH:Proteins)a(MESH:Proteins)p(HGNC:RAB5A)
    Jensa(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")bp(GO:memory)a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Jensa(CHEBI:galanthamine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")p(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HGNC:PIN1)
    Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(NGlyco))a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
    Jensa(PUBCHEM:442534)bp(GO:memory) path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta polypeptide 42")bp(MESH:Neuroprotection)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jens a(CHEBI:"amyloid-beta")g(HBP:"APOE e4")p(HGNC:RELA)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
    Jens a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")bp(GO:endocytosis)
    Jenscomplex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL18)p(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
    Jensa(CHEBI:simvastatin)bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:glycation))
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")a(CHEBI:"amyloid-beta")p(HGNC:NFKB1)path(MESH:Anxiety)
    Jensp(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))a(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"amyloid-beta oligomers") p(HGNC:MAPT) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    Jens a(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex") p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)path(HBP:neurotoxicity)a(CHEBI:galanthamine)bp(GO:cognition)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(OGlyco))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT)p(HGNC:MAPT, frag("?"))path(HBP:Neurodegeneration)a(CHEBI:"potassium(1+)")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:ACHE)
    Jensa(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN1)p(HGNC:BACE1)
    Jensa(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")path(MESH:"Alzheimer Disease")complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:HSPB1)p(HGNC:MAPT, pmod(Ph))
    Jens p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    Jensp(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)a(CHEBI:donepezil)bp(GO:cognition)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"methylene blue")bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("?"))
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA3)path(MESH:"Alzheimer Disease")a(GO:"neurofibrillary tangle")a(HBP:"Tau fibrils")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
    Jens a(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")composite(p(HGNC:APP), p(HGNC:VANGL2))p(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensa(CHEBI:acrolein)a(GO:"neurofibrillary tangle")path(MESH:"Alzheimer Disease")a(CHEBI:curcumin)bp(GO:macroautophagy)p(FPLX:mTORC1)
    Jensa(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)a(CHEBI:acetylcholine)a(CHEBI:nicotine) p(HGNC:CHRNA7)
    Jensa(CHEBI:sirolimus)a(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta") bp(GO:autophagy)p(HGNC:MAPT)
    Jensp(FPLX:PKA)p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:SYK)a(HBP:"Tau oligomers")bp(GO:"long-term synaptic potentiation")p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")p(HGNC:MAPT)p(HGNC:SYK)a(GO:lysosome)p(HGNC:TFEB)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:Temsirolimus)bp(GO:macroautophagy)bp(GO:"long-term synaptic potentiation")p(HGNC:FYN)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(CHEBI:acetylcholine)a(CHEBI:nicotine)
    Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))path(MESH:"Proteostasis Deficiencies")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)p(HGNC:PPARG)
    Jensbp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:SIRT1)a(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:IL1B)
    Jensbp(GO:"cell death")p(HGNC:RNF19A)p(HGNC:SOD1, var("?"))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:rosiglitazone)a(MESH:Microglia)
    Jensbp(GO:locomotion)a(HBP:"Tau aggregates") p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))path(HBP:Neurodegeneration)
    Jensa(CHEBI:lipid)bp(GO:endocytosis)p(HGNC:RAB5A)p(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:IL1B)
    Jensa(GO:autophagosome)a(GO:lysosome)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HBP:"Tau C3")
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ph, Ser, 262))path(MESH:"Alzheimer Disease")
    Jensa(MESH:"Cholinergic Neurons")path(MESH:"Alzheimer Disease")path(MESH:Depression)a(CHEBI:"amyloid-beta")bp(GO:"cell death")p(HGNC:CHRM1)
    Jensa(CHEBI:"amyloid-beta") a(CHEBI:nicotine) bp(GO:memory)p(HGNC:CHRNA7)
    Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:"amyloid-beta")a(GO:lysosome)complex(GO:"NLRP3 inflammasome complex")
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:ACHE)p(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:water)path(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TGM2)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:HSPB1)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(HBP:HBP00006)p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280delinsProPro"))a(HP:"glymphatic system")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")
    Jensa(CHEBI:scopolamine)a(MESH:VU0357017)bp(GO:"behavioral fear response")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
    Jensbp(GO:autophagy)p(HGNC:HSPB1)p(HGNC:MAPT, pmod(Ph))a(HBP:"granulovacuolar degeneration")p(HGNC:MAPT, pmod(Ph, Ser, 262))p(HGNC:MARK4, pmod(Ph))
    Jensa(CHEBI:galanthamine)bp(GO:learning)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
    Jensp(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))complex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CTSD)a(HBP:"Corticobasal Degeneration")p(HGNC:MAPT) p(HGNC:MAPT)path(HBP:neurotoxicity)
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    Jensbp(GO:"protein folding")bp(MESH:Aging)p(FPLX:HSP90)a(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:"learning or memory")bp(MESH:Neuroprotection)p(HGNC:CHRNA7)p(HGNC:JAK2)
    Jensa(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(MESH:Autophagy)
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)bp(GO:cognition)p(HGNC:FYN)path(MESH:"Alzheimer Disease")
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")a(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Kidney)a(CHEBI:donepezil)p(HGNC:BCL2)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRM)a(CHEBI:"lithium atom")bp(GO:autophagy)p(HGNC:MAPT)
    Jensbp(MESH:Aging)p(FPLX:HSP90)p(FPLX:Proteasome)p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP5C)path(MESH:"Alzheimer Disease")
    Jens a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Pro301Leu"))a(MESH:Trehalose)bp(MESH:Autophagy)
    Jensa(CHEBI:"D-ribose")a(CHEBI:"advanced glycation end-product")p(MGI:Mapt, pmod(Ph, Ser, 214))a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Liver)
    Jenscomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
    Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")path(MESH:Schizophrenia)bp(GO:"microtubule polymerization")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jens a(HBP:"Tau aggregates")a(HBP:"Tau oligomers") path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
    Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL18)a(MESH:Lysosomes)bp(MESH:Proteolysis)path(MESH:"Alzheimer Disease")
    Jensa(HBP:HBP00074)bp(GO:"neuron death")path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:IL1B)p(HGNC:NFKB1)
    Jensa(HBP:"Tau epitope, PHF1")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 396))a(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:IL18)
    Jensp(HGNC:MAPT, pmod(Ph))a(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13") path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
    Jensa(CHEBI:"potassium(1+)")complex(GO:"inflammasome complex")p(HGNC:IL1B)p(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)bp(MESH:Neuroprotection)bp(GO:autophagy)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(GO:lysosome)a(GO:lysosome)path(MESH:"Alzheimer Disease")a(CHEBI:galanthamine)bp(GO:learning)p(MGI:App, frag("25_35"))
    Jensbp(HBP:"protein aggregation")complex(a(GO:"proteasome complex"), p(HGNC:BAG6))p(MESH:Proteins, pmod(HBP:misfolding))a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:aging)
    Jensa(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")p(HGNC:PSEN1, var("?"))
    Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")p(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")
    Jensbp(GO:autophagy)p(HGNC:HSPB1)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL1B)
    Jensbp(MESH:Aging)p(FPLX:HSP90)path(MESH:"Protein Aggregation, Pathological")p(FPLX:PPP2)p(HGNC:CDK5)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")bp(GO:aging)a(CHEBI:donepezil)p(HGNC:LRP1) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))bp(GO:"neuron death")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
    Jensa(MESH:D002800)bp(GO:"GO:0014047")path(MESH:D000544)a(CHEBI:nicotine)bp(GO:cognition)p(HGNC:CHRNA7)
    Jensp(HGNC:IL1B)p(HGNC:PYCARD)path(MESH:"Alzheimer Disease")a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(FPLX:CHRN)
    Jensa(CHEBI:sirolimus)bp(GO:cognition)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")complex(GO:"proteasome complex")path(HBP:Neurodegeneration)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"TOR complex")p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:SQSTM1)
    Jensa(MESH:Neurons)a(PUBCHEM:64627)p(MGI:Adora1)bp(GO:autophagy)bp(MESH:Aging)p(FPLX:HSP90)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:antalarmin)path(HBP:"isolation rearing")r(RGD:Ntrk2)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:PTGES3)
    Jensa(HBP:"Tau oligomers")p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")a(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")p(HGNC:ADAM10)p(HGNC:APP)a(CHEBI:galanthamine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)a(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN2)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)path(MESH:"Plaque, Amyloid")a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Tyr))p(HGNC:SYK)
    Jens a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")bp(GO:autophagy)path(HBP:neurotoxicity)
    Jensbp(MESH:"Oxidative Stress")p(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:CHRNA4)a(CHEBI:simvastatin)bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
    Jensp(HGNC:HSPB1)p(HGNC:MAPT)p(HGNC:MAPT)complex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL1B)
    Jensa(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))bp(GO:aging)p(HGNC:IL18) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)path(HBP:Neurodegeneration)bp(GO:"neuron death")p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CHRNA4)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:ACHE)
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Pick Disease of the Brain")p(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRN)p(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")a(CHEBI:"D-ribose")a(CHEBI:"advanced glycation end-product")p(MGI:Mapt, pmod(Ph, Ser, 396))
    Jensa(CHEBI:Temsirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Glu391*"))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Syk)p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Niemann-Pick Diseases")
    Jensa(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")a(MESH:"Dopaminergic Neurons")a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Pro301Leu"))
    Jensa(CHEBI:"iron(0)")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")a(CHEBI:sirolimus)bp(GO:macroautophagy)p(FPLX:mTORC1)
    Jensa(HBP:"Tau aggregates")p(HGNCGENEFAMILY:Caspases)path(MESH:"Neurofibrillary Tangles")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:BACE1)
    Jensa(MESH:Proteins)a(MESH:Proteins)a(MESH:Proteins)a(CHEBI:"amyloid-beta")a(PUBCHEM:16057918)p(HGNC:BCL2L1)
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")
    Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(OGlyco))path(MESH:"Alzheimer Disease")a(CHEBI:sirolimus)bp(GO:autophagy)p(FPLX:mTORC1)
    Jensa(CHEBI:"amyloid-beta")p(FPLX:Proteasome)path(HBP:neurotoxicity)a(MESH:"Cholinergic Neurons")bp(GO:memory)complex(GO:"NF-kappaB complex")
    Jens a(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:IL1B)p(HGNC:ADAM10)p(HGNC:APP)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine)bp(GO:"action potential initiation")p(HGNC:CHRNA7)
    Jensp(HGNC:GSK3B)p(HGNC:GSK3B, pmod(Ph, Ser, 9))p(HGNC:PPP1CA)a(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensbp(GO:aging)p(HGNC:MAPT)a(CHEBI:"Hsp90 inhibitor")a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") p(HGNC:MAPT)
    Jensbp(GO:"microglial cell activation")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:ACHE)
    Jensa(PUBCHEM:675434)p(HGNC:MAPT)p(HGNC:MAPT)a(MESH:"Cholinergic Neurons")path(MESH:"Alzheimer Disease")path(MESH:Depression)
    Jensa(CHEBI:"potassium(1+)")p(HGNC:IL1B)p(HGNC:PYCARD)a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 202))
    Jensp(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))bp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CAPN2)p(HGNC:CAST)p(HGNC:HTT, var("?"))
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HGNC:CHRNA7)a(HBP:"amyloid-beta oligomers")p(HGNC:MAPT, pmod(Ph, Ser, 262))p(INTERPRO:"Kinase associated domain 1 (KA1)")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))p(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 199)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:CHRM1)a(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:"Alzheimer Disease")
    Jensbp(GO:"long-term synaptic potentiation")p(HGNC:HSPB1)p(HGNC:MAPT)a(CHEBI:acetylcholine)a(CHEBI:galanthamine)p(HGNC:CHRNA7)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(CHEBI:water)path(MESH:"Alzheimer Disease")
    Jensa(GO:"neurofibrillary tangle")p(HBP:"CDK5R1 p25")p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK6)a(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL1B)
    Jensp(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))m(MIRBASE:"hsa-mir-155")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensa(GO:microtubule)bp(GO:"anterograde axonal transport")p(HGNC:MAPT)a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, var("p.Ala152Thr"))path(MESH:"Supranuclear Palsy, Progressive")a(CHEBI:galanthamine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)p(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")p(MGI:"oncostatin M")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"long-term synaptic potentiation")complex(GO:"proteasome complex")p(FPLX:PKA)p(FPLX:PKA, pmod(Ub))
    Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:BIN1)complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))
    Jensa(GO:presynapse)a(GO:"neurofibrillary tangle") a(HBP:"Tau aggregates")a(MESH:"BSc 3094")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
    Jensp(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))a(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP3)a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(FPLX:TLR)
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")a(HBP:HBP00018)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:TFEB)a(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(CHEBI:nicotine)
    Jensa(HBP:"Tau oligomers")a(MESH:Neurons)p(HGNC:MAPT)a(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK4)
    Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 396))a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 321)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CAPN2)p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
    Jensbp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))complex(GO:"NF-kappaB complex")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic")a(CHEBI:"amyloid-beta")p(FPLX:ERK) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))p(HGNC:OTUB1)
    Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT)p(HGNC:SQSTM1)a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")
    Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 199))a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 259)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:nicotine)a(CHEBI:galanthamine) bp(GO:cognition) p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")a(GO:synapse)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Jens a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(HGNC:MAPT)
    Jens p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")p(HGNC:MMP2)complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
    Jensa(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:SQSTM1)p(HBP:"4R tau")p(HGNC:MAPT, var("p.Gly272Val"))path(MESH:"Frontotemporal Dementia")
    Jensa(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(GO:macroautophagy)a(CHEBI:"amyloid-beta")a(CHEBI:pioglitazone)p(HGNC:PPARG)
    Jensp(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))a(CHEBI:nicotine)a(MESH:"SNARE Proteins")p(HGNC:CHRNA7)
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:memory)a(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:BACE1)
    Jens a(HBP:"Tau aggregates")p(HGNC:PPID)path(MESH:"Alzheimer Disease")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)bp(GO:memory)a(CHEBI:dextran)a(CHEBI:dextran)a(CHEBI:dextran)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:ACHE)a(CHEBI:"calcium(2+)")bp(MESH:"Oxidative Stress")p(HGNC:S100B)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 290))path(MESH:"Alzheimer Disease")a(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:IL6)
    Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)bp(GO:memory)a(CHEBI:rolipram)complex(GO:"proteasome complex")p(FPLX:PKA)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))a(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))
    Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)a(GO:"neurofibrillary tangle")p(HGNC:CDKN2A)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)a(GO:microtubule)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensbp(GO:aging)p(HGNC:FKBP5)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")
    Jensbp(GO:"long-term synaptic potentiation") p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TREM2)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensa(MESH:"Embryonic Structures")a(MESH:antalarmin)bp(MESH:"Heat-Shock Response")a(HBP:"Tau oligomers")p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))a(HBP:"Tau aggregates")a(HBP:"Tau oligomers")bp(MESH:Autophagy)
    Jensa(CHEBI:galanthamine)bp(GO:cognition)a(CHEBI:"amyloid-beta")p(HGNC:ACE) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:memory)
    Jensa(HBP:"Tau oligomers")complex(GO:axon)p(HGNC:MAPT)p(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Glu391*"))complex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(CHEBI:"amyloid-beta")p(HGNC:MAPK14)p(HGNC:RELA)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:HDAC6)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:cholesterol)bp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")a(CHEBI:"amyloid-beta")a(CHEBI:Anatabine)path(MESH:"Interpersonal Relations")
    Jensa(CHEBI:nicotine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)bp(GO:"MAPK cascade")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 231)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one")bp(GO:memory)bp(GO:cognition)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(MESH:Hippocampus)p(HGNC:CHRNA7)path(MESH:Schizophrenia)p(HGNC:MAPT)p(HGNC:NPEPPS)path(MESH:"Frontotemporal Dementia")
    Jensa(HBP:"Tau epitope, PHF1")bp(MESH:Autophagy)p(HGNC:MAPT)a(CHEBI:galanthamine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 396))bp(GO:"neuron death")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:BCHE)g(HGNC:APOE)p(HGNC:APOE)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Arg406Trp"))p(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Jensa(CHEBI:lactacystin)p(FPLX:Proteasome) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:Tauopathies)p(HGNC:HSF1)p(HGNC:HSF1)p(HGNC:HSF1)
    Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:Microglia)
    Jens a(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:aging)a(CHEBI:"amyloid-beta")bp(GO:endocytosis)
    Jensp(HGNC:MAPT, pmod(OGlyco))p(HGNC:MAPT, pmod(Ph))p(HGNC:HSPB1)p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Jensbp(MESH:Aging)p(FPLX:HSP90)p(HGNC:STIP1)a(CHEBI:"reactive oxygen species")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:"peroxisome proliferator activated receptor signaling pathway")
    Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(GO:memory)g(HGNC:NLRP3)
    Jensa(CHEBI:nicotine)bp(GO:"MAPK cascade")p(FPLX:NFkappaB)a(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensp(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")bp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Ala152Thr"))
    Jensbp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))a(HBP:"Tau oligomers")p(HGNC:MAPT)path(HBP:Neurodegeneration)
    Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")a(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jensbp(GO:"anterograde axonal protein transport")p(HBP:"6D tau", frag("2_18"))p(MESH:"Glycogen Synthase Kinase 3")a(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:MAPT)
    Jensa(CHEBI:"alpha-tocopherol") a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:IDE)bp(GO:memory)
    Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")a(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:donepezil)bp(GO:cognition)path(MESH:"Alzheimer Disease")a(CHEBI:nicotine)a(HBP:"Tau aggregates")path(HBP:neurotoxicity)
    Jensp(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(HBP:"protein aggregates")bp(GO:autophagy)path(MESH:"Amyotrophic Lateral Sclerosis")
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")path(HBP:neurotoxicity)p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Chrna7)a(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:SNCA)
    Jensa(GO:presynapse)a(PUBCHEM:64627)p(MGI:Adora1)p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:STUB1)
    Jensa(MESH:Proteins)a(MESH:Proteins)p(HGNC:RAB5A)a(CHEBI:galanthamine)bp(GO:learning)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, var("p.Ala152Thr"))p(HGNC:BACE1)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))a(CHEBI:"okadaic acid")p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, pmod(Sumo, Lys, 340))
    Jensa(CHEBI:Calpeptin)p(HGNC:CAPN2)p(HGNC:HTT, var("?"))a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(OGlyco)) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"proteasome inhibitor")bp(GO:autophagy)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:BIN1)a(HBP:HBP00074)bp(GO:aging) path(MESH:"Alzheimer Disease")
    Jensbp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:APP)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
    Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:SQSTM1)a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
    Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TGM2)a(GO:"neurofibrillary tangle")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202))p(FPLX:ERK)p(FPLX:NFkappaB)p(HGNC:TNF)
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")complex(GO:"proteasome complex")p(HGNC:PRKN)p(HGNC:SNCA)
    Jensa(CHEBI:ceramide)complex(GO:"protein phosphatase type 2A complex")a(GO:"neurofibrillary tangle")p(HGNC:TGM2) path(MESH:"Alzheimer Disease")
    Jensbp(GO:cognition)complex(GO:"protein phosphatase type 2A complex") p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Lys280del"))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:heparin)a(HBP:"Tau aggregates") a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Gly272Val"))
    Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT, pmod(Ph, Ser, 356))p(INTERPRO:"Kinase associated domain 1 (KA1)")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(GO:aging)
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55"))p(HGNC:MAPT, pmod(Ph))bp(MESH:Aging)p(HGNC:PTGES3)path(MESH:"Protein Aggregation, Pathological")
    Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:TREM2, var("p.Arg47His"))
    Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(FPLX:PPP2, pmod(Ph, Tyr, 307))p(HGNC:PTPA)
    Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL18)a(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00018)bp(GO:"microglial cell activation")p(HGNC:NR1H3) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(MESH:Neuroprotection)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")bp(GO:"microglial cell activation")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)a(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")p(FPLX:NFkappaB)
    Jensa(HBP:HBP00018)a(HBP:HBP00030)a(MESH:"Amyloid beta-Peptides")p(HGNC:TNF) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:lactacystin)p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"trichostatin A")p(FPLX:HDAC)p(HGNC:MAPT, pmod(Ac))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
    Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HGNC:PIN1)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRM)
    Jensp(HGNC:CDK5)p(HGNC:IL18)path(MESH:"Alzheimer Disease")a(MESH:Proteins)a(MESH:Proteins)bp(GO:endocytosis)
    Jensa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:MAPT)a(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))p(HGNC:MAPT, pmod(Ph, Thr, 205))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
    Jensa(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)bp(GO:"microtubule polymerization")p(HGNC:MAPT) p(HGNC:MAPT)
    Jensa(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)a(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")composite(p(HGNC:APP), p(HGNC:VANGL2))
    Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 199))a(HBP:"amyloid-beta aggregates")p(HGNC:APP, var("?")) path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:pioglitazone)p(HGNC:PPARG)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"apoptotic process")
    Jensbp(GO:aging)a(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")bp(GO:"mitochondrion organization")bp(HP:Neurodegeneration)complex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensbp(GO:autophagy)a(CHEBI:epoxomicin)p(HGNC:MAPT) p(HGNC:MAPT)path(HBP:neurotoxicity)
    Jensa(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Ser, 396))p(HGNC:MAPT)p(HGNC:TGM2)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"apoptotic process")bp(GO:"MAPK cascade")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)p(HGNC:CAPN2)p(HGNC:CAST)p(FPLX:NFkappaB)p(FPLX:NFkappaB)p(FPLX:NFkappaB)
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one")bp(GO:memory)
    Jensa(CHEBI:donepezil)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(HBP:"alpha-synuclein aggregates")p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") path(MESH:"Alzheimer Disease")
    Jensbp(GO:"depolarization of postsynaptic membrane")complex(GO:"voltage-gated calcium channel complex")p(HBP:"alpha-4 beta-2 nAChR")a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 353))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRM1)p(HGNC:MAPT, pmod(Ph))a(HBP:HBP00074)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
    Jensbp(GO:aging)bp(GO:locomotion)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))
    Jensp(HGNC:AK1)p(HGNC:APP)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:ACHE)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ph, Ser, 262))a(HBP:"Tau aggregates")a(MESH:Autophagosomes) path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)bp(GO:"apoptotic process")p(FPLX:TLR)p(HGNC:IL1B)
    Jensa(CHEBI:"amyloid-beta")a(GO:synapse)bp(GO:endocytosis)complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
    Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:SNCA)g(HBP:"APOE e4")p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:APP)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")a(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")
    Jensa(HBP:"Tau aggregates")a(PUBCHEM:9804992)p(FPLX:HDAC)p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")
    Jensa(HBP:"Tau aggregates")a(CHEBI:"methylene blue")bp(MESH:Autophagy) p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
    Jensa(CHEBI:"lithium atom")bp(GO:autophagy)p(HGNC:MAPT)a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(FPLX:CHRN)
    Jensa(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")a(HBP:"Tau aggregates")p(HGNCGENEFAMILY:Caspases)path(MESH:"Neurofibrillary Tangles")
    Jensbp(GO:"proteasomal protein catabolic process")p(HGNC:HSPB1)p(HGNC:MAPT)bp(GO:endocytosis)g(HBP:"APOE e4")p(HGNC:APP)
    Jensa(MESH:"Amyloid beta-Peptides")p(HGNC:BECN1)path(MESH:"Alzheimer Disease")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")a(MESH:"Dopaminergic Neurons")
    Jensa(MESH:antalarmin)path(HBP:"isolation rearing")r(RGD:Ntrk2)a(HBP:"Tau epitope, PHF1")bp(MESH:Autophagy)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)bp(GO:endocytosis)a(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)p(HGNC:MAPT)bp(GO:"long-term synaptic potentiation")p(HGNC:NFKB1)
    Jensp(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))a(CHEBI:lactacystin)p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:RAB5A)a(CHEBI:rolipram)a(HBP:"Tau aggregates")complex(GO:"proteasome complex")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:ABCB1)a(CHEBI:acrolein)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))p(HBP:HBP00065) path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensbp(GO:cognition)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:APP)
    Jensa(HBP:HBP00074)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")a(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")bp(MESH:Aging)p(FPLX:HSPA)path(MESH:"Protein Aggregation, Pathological")
    Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)a(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN1)
    Jensbp(GO:"neuron death")bp(GO:autophagy)complex(GO:"proteasome complex") p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:galanthamine)bp(GO:learning)p(MGI:App, frag("25_35"))a(CHEBI:"amyloid-beta")a(GO:synapse)bp(GO:endocytosis)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)a(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:JAK2)
    Jensp(HBP:"4R tau")p(HGNC:SRSF2)path(MESH:"Supranuclear Palsy, Progressive")a(CHEBI:nicotine)a(MESH:"Dopaminergic Neurons")p(FPLX:CHRN)
    Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
    Jensp(HGNC:PRKN)p(HGNC:SNCA)a(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")a(HBP:"Tau epitope, PHF1")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Jens a(CHEBI:"amyloid-beta")p(MESH:Neprilysin)path(MESH:"Alzheimer Disease")bp(GO:memory)p(HGNC:BACE1)
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:CHRNA4)
    Jensa(CHEBI:wortmannin)bp(GO:autophagy) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 202))a(HBP:"Tau aggregates")p(HBP:"Tau epitope, AT8")p(MGI:Crhr1)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Supranuclear Palsy, Progressive")complex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph))
    Jensa(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:Microglia)p(HGNC:IL1B)p(HGNC:PYCARD)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRM1)a(CHEBI:"alpha,alpha-trehalose")bp(GO:autophagy)p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)
    Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:CHRNA7)complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
    Jensa(MESH:Proteins)bp(GO:endocytosis)p(HGNC:RAB5A)p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:PICALM)a(CHEBI:"reactive oxygen species")p(FPLX:ERK)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:nicotine)bp(GO:"MAPK cascade")p(HBP:"alpha-4 beta-2 nAChR")
    Jensbp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))a(HBP:HBP00006)p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280delinsProPro"))
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)a(CHEBI:donepezil)p(HGNC:ABCB1) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine)p(FPLX:CHRN)bp(GO:"synaptic transmission, cholinergic")bp(GO:memory)
    Jensa(GO:autolysosome)bp(GO:"lysosomal protein catabolic process")path(MESH:"Alzheimer Disease")p(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")a(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Ser, 214))
    Jensp(HGNC:CHAT)path(MESH:"Alzheimer Disease")path(MESH:Dementia)a(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(FPLX:CHRN)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")complex(GO:"proteasome complex")a(CHEBI:rolipram)p(HGNC:MAPT)p(HGNC:MAPT)
    Jens a(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")complex(p(HGNC:APP), p(HGNC:LRP1))p(HGNC:APP)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:LRP1)p(HBP:"4R tau")p(HGNC:SRSF2)path(MESH:"Supranuclear Palsy, Progressive")
    Jensa(GO:lysosome)g(HGNC:APP, var("?"))a(CHEBI:Thrombin)a(HBP:"Tau aggregates") path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"dimethyl fumarate")p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, var("?"))a(CHEBI:galanthamine)p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
    Jensbp(GO:endocytosis)g(HBP:"APOE e4")p(HGNC:APP)bp(GO:"protein folding")bp(MESH:Aging)p(FPLX:HSP90)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Tyr))p(HGNC:SYK)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"MAPK cascade")
    Jensp(HGNC:SNCA)p(HGNC:SNCA, pmod(Ub))path(MESH:"Parkinson Disease")a(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")p(HGNC:MAPT)
    Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:IL1B)
    Jenscomplex(GO:"proteasome complex")p(FPLX:PKA)p(FPLX:PKA, pmod(Ub))a(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(GO:phagocytosis)p(HGNC:TREM2)
    Jens a(CHEBI:"amyloid-beta")p(HGNC:IDE)path(MESH:"Alzheimer Disease")bp(GO:endocytosis)p(HGNC:BIN1)
    Jensa(GO:microtubule) a(HBP:"Tau oligomers")p(HGNC:MAPT)a(HBP:"Tau oligomers")path(MESH:Tauopathies)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(GO:autolysosome)bp(GO:"lysosomal protein catabolic process")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:memory)p(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"alpha,alpha-trehalose")bp(GO:autophagy)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")complex(GO:"NF-kappaB complex")
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(a(GO:"membrane attack complex"), p(HGNC:C5))
    Jensp(HGNC:MAPT, pmod(Ph, Thr, 205))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))m(HGNC:MIR125B1)p(HGNC:CDKN2A)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:resveratrol)p(HGNC:MID1)p(HGNC:PPP2CA)bp(MESH:Aging)p(FPLX:HSP90)p(HGNC:PTGES3)
    Jensbp(GO:"long-term synaptic potentiation") p(HGNC:MAPT) p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")
    Jensa(CHEBI:"methylene blue")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))bp(GO:macroautophagy)p(FPLX:AMPK)p(FPLX:mTORC1)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 174))p(FPLX:GSK3) p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(PUBCHEM:377503130)p(FPLX:"CCT_complex")p(HGNC:HSF1)
    Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1) p(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:LRP1)bp(GO:autophagy)p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))
    Jensa(MESH:Lysosomes)p(HGNC:MAPT)p(HGNC:IL18)p(HGNC:PYCARD) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")a(HBP:"Tau oligomers")bp(GO:"mitochondrion organization")bp(HP:Neurodegeneration)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 259))path(MESH:"Alzheimer Disease")bp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph))a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")complex(p(HGNC:MAPT), p(HGNC:TGM2))
    Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT)a(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:BCL2)
    Jensp(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")a(CHEBI:"amyloid-beta")bp(GO:memory)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(FPLX:PPP2) p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)a(CHEBI:"amyloid-beta")bp(GO:endocytosis)bp(GO:memory)
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:MAPT, pmod(Ph, Thr, 205))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)bp(MESH:Neuroprotection)
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)path(MESH:"Alzheimer Disease")a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")path(MESH:"Protein Aggregation, Pathological")
    Jensa(HBP:HBP00093)bp(GO:autophagy)p(HGNC:HDAC6)a(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 404))a(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:RELA)
    Jens bp(GO:"neuron death")p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:Thrombin) p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
    Jensa(CHEBI:"okadaic acid")p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, pmod(Sumo, Lys, 340))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
    Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(MESH:Autophagy)a(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:SYK)p(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))
    Jensp(HBP:HBP00065)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")a(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HBP:"alpha-4 beta-2 nAChR")
    Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 199))a(HBP:"Tau aggregates")p(HGNC:AHSA1) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")bp(GO:autophagy)p(HGNC:CAPN1)p(HGNC:CAST)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:CHRN)a(CHEBI:wortmannin)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph, Ser, 262))
    Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")bp(GO:autophagy)p(FPLX:AMPK)p(FPLX:mTORC1)
    Jensp(HGNC:APP, frag("672_713"))p(HGNC:BACE1)path(MESH:"Alzheimer Disease")a(CHEBI:nicotine)bp(GO:cognition)p(HBP:"alpha-4 beta-2 nAChR")
    Jensa(CHEBI:"proteasome inhibitor")p(HGNC:BAG3)p(HGNC:MAPT)complex(a(GO:"proteasome complex"), p(HGNC:PRKN))p(HGNC:PRKN, var("p.Arg42"))path(MESH:"Parkinsonian Disorders")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Liver)a(CHEBI:Thrombin)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:galanthamine)p(FPLX:CHRN)bp(MESH:Aging)p(HGNC:AHSA1) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:endocytosis)a(HBP:"Tau oligomers")p(HGNC:MAPT, var("p.Ala152Thr"))path(MESH:"Supranuclear Palsy, Progressive")
    Jensa(CHEBI:galanthamine)bp(GO:cognition)p(HGNC:CHRNA7)bp(GO:aging)p(HGNC:MAPT)p(HGNC:SYK)
    Jensbp(GO:"apoptotic process")p(HGNC:CDK5)p(HGNC:MAPK1)a(CHEBI:"proteasome inhibitor")bp(GO:autophagy)p(HGNC:MAPT)
    Jensa(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")a(HBP:HBP00074)p(HGNC:NGFR)path(MESH:"Cognitive Dysfunction")
    Jensa(GO:"neurofibrillary tangle")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))p(MGI:Mapt)a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)
    Jensbp(GO:"clathrin-dependent endocytosis")p(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))
    Jens a(CHEBI:"amyloid-beta")p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")a(CHEBI:nicotine)p(HGNC:TNF)
    Jensbp(MESH:Aging)bp(MESH:Proteolysis)p(FPLX:HSP90)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:ACE)
    Jens a(CHEBI:"amyloid-beta")bp(GO:aging)bp(GO:"lysosomal protein catabolic process") path(MESH:"Alzheimer Disease")
    Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:FYN)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")complex(GO:"proteasome complex")
    Jensa(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Thr, 181))a(CHEBI:"amyloid-beta")bp(GO:aging)bp(GO:locomotion)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Jensa(CHEBI:"potassium(1+)")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)bp(GO:endocytosis)g(HBP:"APOE e4")p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
    Jensa(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:NGFR) path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
    Jens a(CHEBI:"amyloid-beta")a(MESH:"Cholinesterase Inhibitors")path(MESH:"Alzheimer Disease")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)a(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
    Jensbp(GO:"microtubule polymerization")p(HGNC:DAPK1)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:"learning or memory")
    Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1)p(HGNC:MAPT)a(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:SNCA)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")path(HBP:neurotoxicity)
    Jensa(GO:lysosome)a(HBP:"Tau aggregates")path(HBP:Neurodegeneration)complex(GO:"NF-kappaB complex")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
    Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)bp(GO:"MAPK cascade")p(HGNC:BCL2L1)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404)) path(MESH:"Alzheimer Disease")
    Jensa(MESH:Nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ub))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:IL1B)a(HBP:HBP00018) path(MESH:"Alzheimer Disease")path(MESH:Dementia)path(MESH:"Plaque, Amyloid")
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Val337Met"))a(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)bp(GO:macroautophagy)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:D002800)p(HGNC:ITPKB)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"potassium(1+)")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)bp(GO:"microtubule polymerization")p(HGNC:DAPK1)p(HGNC:MAPT)
    Jensa(CHEBI:nicotine)a(MESH:"Dopaminergic Neurons")p(FPLX:CHRN)a(CHEBI:sirolimus)bp(GO:macroautophagy)p(HGNC:SNCA)
    Jensa(CHEBI:donepezil)p(HGNC:ABCB1)p(HGNC:CHRNA7)p(HGNC:CHRNA7) path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau epitope, PHF1")bp(GO:"microglial cell activation")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
    Jensbp(MESH:"Oxidative Stress") p(HGNC:GSK3B) p(HGNC:MAPT)
    Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:SNCA)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM2)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:CHRNA7)a(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)bp(HBP:"protein aggregation")complex(p(HGNC:BAG6), p(HGNC:UBA3))p(MESH:Proteins, pmod(HBP:misfolding))
    Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))a(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:DKK1)
    Jensa(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))bp(GO:aging)bp(GO:locomotion)p(HGNC:MAPT)
    Jensa(CHEBI:nicotine)bp(GO:cognition)p(HBP:"alpha-4 beta-2 nAChR")a(CHEBI:"Hsp90 inhibitor")p(HGNC:MAPT)p(HGNC:MAPT)
    Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")p(MGI:Chrna7)
    Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)p(HGNC:SYK)a(CHEBI:"D-ribose")a(CHEBI:"advanced glycation end-product")p(MGI:Mapt, pmod(Ph, Ser, 214))
    Jensa(CHEBI:rivastigmine)p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)p(MESH:"I-kappa B Proteins", pmod(Ph))
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")
    Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")a(PUBCHEM:9804992)p(FPLX:HDAC)
    Jensa(CHEBI:donepezil)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")bp(MESH:Aging)p(FPLX:HSP90)p(FPLX:Proteasome)
    Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:CHAT)a(MESH:"Embryonic Structures")a(MESH:antalarmin)bp(MESH:"Heat-Shock Response")
    Jens a(CHEBI:"amyloid-beta")a(MESH:Synapses)p(FPLX:PI3K)bp(GO:"neuron death")bp(GO:proteolysis)
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:IDE)
    Jensbp(GO:autophagy)complex(GO:"proteasome complex")p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)bp(GO:"apoptotic process")
    Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(MESH:Tauopathies)a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:glycation))a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
    Jensa(CHEBI:"amyloid-beta")bp(GO:memory)path(MESH:"Alzheimer Disease")a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:ACHE)
    Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Chronic Traumatic Encephalopathy")a(GO:"neurofibrillary tangle")p(HBP:"CDK5R1 p25")path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:MAPT)p(HGNC:CDK5)p(HGNC:MAPK1)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:JAK2)bp(GO:"apoptotic process")p(FPLX:AKT)p(HGNC:RELA)
    Jensa(CHEBI:Thrombin)a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")bp(GO:"cell death")p(HGNC:RNF19A)p(HGNC:SOD1, var("?"))
    Jensa(GO:"neurofibrillary tangle")p(HGNC:CDKN2A)path(MESH:"Supranuclear Palsy, Progressive")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)complex(GO:"NF-kappaB complex")
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph))a(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)p(HGNC:MAPT)
    Jensa(CHEBI:Anatabine)a(GO:"myelin sheath")path(MESH:Encephalomyelitis)p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))
    Jensa(CHEBI:"amyloid-beta")bp(GO:macroautophagy)p(HGNC:TFEB)complex(GO:"neuron projection")p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates") path(HBP:neurotoxicity)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:galanthamine)p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")
    Jens a(CHEBI:"amyloid-beta") a(CHEBI:nicotine)path(HBP:neurotoxicity)
    Jens a(CHEBI:"amyloid-beta")bp(GO:endocytosis)g(HBP:"APOE e4")a(CHEBI:wogonin)bp(GO:autophagy)
    Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:PPP2, pmod(Ph, Tyr, 307))p(HGNC:PTPA)a(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")p(FPLX:PKC)
    Jensa(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")p(FPLX:NFkappaB)p(HGNC:TNF) path(MESH:"Alzheimer Disease")
    Jensa(HBP:HBP00093)bp(GO:autophagy)p(HGNC:TFEB)bp(GO:aging)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:AGER)path(MESH:"Alzheimer Disease")p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(HBP:"Corticobasal Degeneration")
    Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")p(HGNC:PSEN1, var("?"))a(CHEBI:wogonin)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
    Jensa(CHEBI:Calpeptin)p(HGNC:CAPN1)p(HGNC:HTT, var("?"))bp(GO:"chaperone-mediated autophagy")bp(MESH:Aging)path(MESH:"Protein Aggregation, Pathological")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 181))path(MESH:"Alzheimer Disease")a(CHEBI:Anatabine)a(GO:"myelin sheath")path(MESH:Encephalomyelitis)
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Gly272Val"))bp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Jensa(CHEBI:"amyloid-beta")p(HGNC:IL18)a(MESH:"Amyloid beta-Peptides")p(HGNC:APP) path(MESH:"Alzheimer Disease")
    Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:TNF)
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:IL18)
    Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 202))a(GO:lysosome)a(GO:lysosome) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT)p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")
    Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)p(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:BCL2)p(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:sirolimus)bp(GO:macroautophagy)p(FPLX:mTORC1)a(CHEBI:Calpeptin)p(HGNC:CAPN1)p(HGNC:HTT, var("?"))
    Jens a(CHEBI:"amyloid-beta polypeptide 42")bp(GO:phagocytosis)p(HGNC:TREM2)a(CHEBI:"amyloid-beta")a(MESH:Microglia)
    Jensa(CHEBI:nilotinib)bp(GO:macroautophagy)p(HGNC:ABL1)a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)p(HGNC:PPARG)a(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)
    Jensa(CHEBI:"D-ribose")a(HBP:"advanced glycation end product")p(HGNC:MAPT, pmod(Ph, Ser, 214))a(CHEBI:"amyloid-beta")a(MESH:"Cholinesterase Inhibitors")path(MESH:"Alzheimer Disease")
    Jensg(HBP:"APOE e4")p(HGNC:APP)p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280)) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404))bp(GO:"neuron death")complex(GO:"protein phosphatase type 2A complex")path(MESH:"Alzheimer Disease")
    Jensa(HBP:"alpha-synuclein aggregates")p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")a(GO:autophagosome)a(GO:lysosome) path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)bp(GO:macroautophagy)bp(GO:autophagy)p(HGNC:CAPN2)p(HGNC:CAST)
    Jensa(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HGNC:CHRNA7)a(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")p(HGNC:MAPT, frag("?"))
    Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)a(PUBCHEM:16057918)complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
    Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")bp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
    Jensbp(GO:"microtubule polymerization")complex(GO:microtubule)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
    Jensp(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:PPP1CA)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:CHRN)
    Jensp(HGNC:IL18)p(HGNC:PYCARD)a(HBP:"amyloid-beta aggregates") path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)a(HBP:HBP00018)a(MESH:Lysosomes)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:memantine)bp(GO:cognition)path(MESH:"Alzheimer Disease")a(CHEBI:acetylcholine)bp(GO:"action potential initiation")p(HGNC:CHRNA7)
    Jensa(HP:"glymphatic system")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")a(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:CHRNA7)
    Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"phosphatase-activating domain")a(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
    Jensa(CHEBI:dopamine)a(HBP:HBP00093)path(MESH:"Parkinson Disease")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
    Jens a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")p(HGNC:ACE)p(MGI:Bace1)
    Jensa(CHEBI:galanthamine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")g(HBP:"APOE e4")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)bp(HBP:"protein aggregation")complex(a(GO:"proteasome complex"), p(HGNC:BAG6))p(MESH:Proteins, pmod(HBP:misfolding))
    Jensa(MESH:Brain)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(MESH:Autophagosomes)
    Jensa(CHEBI:geldanamycin)p(FPLX:HSP90)p(HGNC:HSF1)a(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)
    Jens a(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)bp(GO:"lysosomal microautophagy")complex(GO:"TOR complex")
    Jens a(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")p(HGNC:CHRNA7)a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Jensa(HBP:"Tau oligomers")bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Anatabine)p(HGNC:CHRNA7)
    Jens a(CHEBI:"amyloid-beta")a(HBP:HBP00018)p(HGNC:TFEB)a(HP:"interstitial fluid")bp(GO:aging)
    Jensbp(GO:autophagy)p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))a(CHEBI:"amyloid-beta")p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
    Jensa(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))a(HBP:"Tau aggregates")bp(GO:"axonal transport")path(HBP:Neurodegeneration)
    Jens a(CHEBI:"amyloid-beta")a(MESH:Microglia)bp(GO:phagocytosis)p(HGNC:MMP2)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(FPLX:TLR)p(HGNC:IL1B)p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))
    Jens a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BAX)a(HBP:"Tau epitope, PHF1")p(HGNC:MAPT)
    Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") a(CHEBI:"amyloid-beta")p(HGNC:SYK)a(CHEBI:"amyloid-beta")complex(GO:"TOR complex")
    Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 396))
    Jensp(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))a(CHEBI:"amyloid-beta")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199))a(CHEBI:rivastigmine)p(HGNC:LRP1) path(MESH:"Alzheimer Disease")
    Jensp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph, Tyr, 18))a(HBP:"Tau aggregates")p(HGNC:PPID) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
    Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 214))complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"neuron death")a(HBP:HBP00006)p(HBP:HBP00053, var("p.Lys280del"))p(HGNC:MAPT)
    Jensa(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")bp(GO:learning)p(MGI:App, frag("25_35"))a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
    Jensa(CHEBI:"calcium(2+)")p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)a(CHEBI:rivastigmine)p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")path(MESH:Schizophrenia)
    Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 202))a(CHEBI:sirolimus)p(HGNC:MAPT) path(MESH:"Alzheimer Disease")
    Jensbp(GO:aging)p(HGNC:MAPT)p(HGNC:SYK)a(CHEBI:rivastigmine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
    Jensbp(GO:autophagy)p(FPLX:AMPK)p(FPLX:mTORC1)a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:CHRNA4)
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)a(CHEBI:lipid)bp(GO:endocytosis)p(HGNC:RAB5A)
    Jensbp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 202))
    Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")path(MESH:"Protein Aggregation, Pathological")a(CHEBI:"amyloid-beta")p(HGNC:APP)path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Lys280del"))a(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))
    Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"neuron death")
    Jensp(HGNC:AK1)p(HGNC:MAPT)p(HGNC:PTGS2) path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
    Jensa(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")
    Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 202)) path(MESH:"Alzheimer Disease")
    Jensa(MESH:methyllycaconitine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)bp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:RAB5A)
    Jensa(CHEBI:"amyloid-beta polypeptide 42") a(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:DKK1)path(HBP:neurotoxicity)
    Jensa(HBP:HBP00018)p(HGNC:IDE)path(MESH:"Alzheimer Disease")a(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MAPT)
    Jensp(HBP:"CDK5R1 p25")p(HBP:"Tau epitope, AT8")p(MGI:Cdk5)bp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:dopamine) a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")p(HGNC:CHRNA7)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:LRP1)a(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, var("?"))
    Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
    Jens a(CHEBI:"amyloid-beta")p(HGNC:MARK4)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)
    Jensa(CHEBI:rivastigmine)p(HGNC:LRP1)path(MESH:"Alzheimer Disease")bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)
    Jensa(CHEBI:rolipram)complex(GO:"proteasome complex")p(HGNC:MAPT)a(GO:lysosome)a(GO:lysosome)a(GO:lysosome)
    Jensa(MESH:"Neurofibrillary Tangles")bp(GO:autophagy) p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SQSTM1)
    Jensa(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
    Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(HBP:neuroinflammation)a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRM1)
    Jensa(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:CCL2)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
    Jensp(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")complex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT)
    Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic") p(HGNC:ACHE)
    Jensa(CHEBI:"amyloid-beta")bp(GO:"cell death")p(HGNC:CHRM1)a(CHEBI:"okadaic acid")p(FPLX:PPP2)p(HGNC:MAPT, pmod(Ph))
    Jens a(CHEBI:"amyloid-beta")bp(GO:memory)p(HGNC:BACE1)
    Jensbp(GO:cognition)p(HGNC:CHRNA7)p(HGNC:CHRNA7)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")
    Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 422))a(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)bp(GO:"autophagosome assembly")
    Increase Mismatch a(CHEBI:"amyloid-beta")
    Increase Mismatch a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")p(HGNC:RELA)bp(GO:"apoptotic process")
    Increase Mismatcha(CHEBI:"amyloid-beta") path(MESH:"Alzheimer Disease")p(HGNC:CTSD)a(GO:lysosome)p(HGNC:CHRNA7)
    Increase Mismatch path(MESH:"Alzheimer Disease")path(MESH:Dementia)p(HGNC:MAPT)p(HGNC:CTSD)a(GO:lysosome)
    Increase Mismatch path(MESH:"Alzheimer Disease")p(HGNC:MAPT) p(HGNC:MAPT, pmod(Ph, Thr, 231))p(HGNC:MAPT)
    Increase Mismatchpath(MESH:"Alzheimer Disease") p(HGNC:MAPT)bp(GO:neurogenesis)p(HGNC:GSK3B)path(MESH:Dementia)
    Increase Mismatch p(HGNC:MAPT)a(GO:microtubule)bp(GO:neurogenesis)p(HGNC:GSK3B)
    Increase Mismatchp(HGNC:MAPT) p(HGNC:MAPT)a(GO:microtubule)
    path(MESH:"Alzheimer Disease")
    Increase Mismatcha(CHEBI:"reactive oxygen species")p(FPLX:ERK)bp(GO:neurogenesis)
    Increase Mismatcha(CHEBI:galanthamine)bp(GO:cognition)a(CHEBI:acetylcholine)
    Increase Mismatch p(HGNC:APP, var("?"))path(MESH:"Alzheimer Disease") bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
    Increase Mismatch a(CHEBI:nicotine)a(CHEBI:acetylcholine) bp(GO:cognition)a(CHEBI:acetylcholine)
    Increase Mismatch p(HBP:"APOE e4")p(MGI:Cdk5r1) p(MGI:Cdk5)p(MGI:Cdk5r1)
    Increase Mismatch p(HGNC:CHRM1)a(CHEBI:acetylcholine) bp(GO:cognition)a(CHEBI:acetylcholine)
    Increase Mismatch a(CHEBI:"nicotinic acetylcholine receptor agonist")a(CHEBI:acetylcholine) bp(GO:cognition)a(CHEBI:acetylcholine)
    Increase Mismatch a(PUBCHEM:9867750)bp(GO:cognition) a(CHEBI:acetylcholine)bp(GO:cognition)
    Increase Mismatch a(HBP:HBP00030)a(CHEBI:"amyloid-beta polypeptide 42") path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta polypeptide 42")
    Increase Mismatch p(HGNC:SQSTM1)bp(GO:autophagy) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
    Increase Mismatch p(HGNC:TFEB)bp(GO:macroautophagy) a(CHEBI:"amyloid-beta")bp(GO:macroautophagy)
    Increase Mismatch bp(GO:"protein K63-linked ubiquitination")complex(GO:"proteasome complex") bp(GO:autophagy)complex(GO:"proteasome complex")
    Increase Mismatch bp(GO:"proteasomal protein catabolic process")p(HGNC:MAPT, pmod(Ub)) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    Increase Mismatch a(CHEBI:rolipram)complex(GO:"proteasome complex") p(HGNC:MAPT)complex(GO:"proteasome complex")
    Increase Mismatch complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:MAPT, pmod(Ph)) rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))p(HGNC:MAPT, pmod(Ph))
    Increase Mismatch p(HGNC:DAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 396))p(HGNC:MAPT, pmod(Ph, Ser, 262)) bp(GO:"apoptotic process")
    Increase Mismatch p(HGNC:DAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 396)) bp(GO:"apoptotic process")p(HGNC:MAPT, pmod(Ph, Ser, 262))
    Decrease Mismatch a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta") complex(GO:"proteasome complex")a(CHEBI:"amyloid-beta")
    Decrease Mismatch path(MESH:"Alzheimer Disease")a(MESH:Brain) p(FPLX:CHRN)a(MESH:Brain)
    Decrease Mismatch path(MESH:"Alzheimer Disease")a(CHEBI:acetylcholine) bp(GO:cognition)a(CHEBI:acetylcholine)
    Decrease Mismatch p(HGNC:MAPT)bp(GO:autophagy)path(HBP:Neurodegeneration) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
    Decrease Mismatch p(HGNC:MAPT) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")path(HBP:Neurodegeneration)bp(GO:autophagy)
    Decrease Mismatcha(CHEBI:donepezil)p(HGNC:ACHE)a(CHEBI:galanthamine) path(MESH:"Alzheimer Disease")p(HGNC:ACHE)
    Decrease Mismatcha(CHEBI:rivastigmine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")a(PUBCHEM:164676)p(HGNC:RELA)bp(GO:"apoptotic process")
    Decrease Mismatcha(CHEBI:galanthamine)a(CHEBI:donepezil)path(MESH:"Alzheimer Disease") p(HGNC:ACHE)
    Decrease Mismatcha(CHEBI:rivastigmine) path(MESH:"Alzheimer Disease")p(HGNC:ACHE)
    Decrease Mismatch a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")path(MESH:"Alzheimer Disease") p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
    Decrease Mismatch a(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex") p(HGNC:PPME1)complex(GO:"protein phosphatase type 2A complex")
    complex(GO:"protein phosphatase type 2A complex")
    Decrease Mismatchp(HGNC:OTUB1)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))
    Decrease Mismatch p(HGNC:STIP1)
    Decrease Mismatch p(HGNC:HTT, var("?"))bp(GO:autophagy) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
    Decrease Mismatch p(HGNC:USP14)complex(GO:"proteasome complex") p(HGNC:MAPT)complex(GO:"proteasome complex")
    Decrease Mismatch p(FPLX:mTORC1)bp(GO:autophagy) bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
    Decrease Mismatch p(HGNC:LRRK2, var("?"))bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") bp(GO:autophagy)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
    Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:IL1B)
    Chaoticp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)
    Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
    Chaotic a(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(FPLX:TLR) p(HGNC:IL1B)
    Chaotic a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:"calcium(2+)") p(HGNC:CHRNA7)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)
    Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
    Chaotica(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")bp(HBP:Excitotoxicity)
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
    Chaotic a(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:JAK2)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
    Chaotica(CHEBI:"amyloid-beta")a(CHEBI:simvastatin) a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")
    Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL18)p(HGNC:IL1B)
    Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:IL6)
    Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
    Chaotica(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")p(HGNC:MAPT)
    Chaotic a(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")bp(HBP:Excitotoxicity)p(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:IL1B)
    Chaotica(CHEBI:"calcium(2+)") a(CHEBI:acetylcholine)bp(GO:"membrane depolarization") p(FPLX:CHRN)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")a(MESH:Microglia)p(HGNC:MAPT)
    Chaoticp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")complex(GO:"NF-kappaB complex")
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")a(MESH:Microglia)p(HGNC:IL1B)
    Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Chaotic p(HGNC:GSK3B) p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
    Chaotica(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(FPLX:CHRN)complex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaotica(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"amyloid-beta polypeptide 42")bp(GO:phagocytosis)p(HGNC:TREM2)
    Chaotica(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNC:CHRNA7)a(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)p(HGNC:CHRNA7)complex(GO:"NF-kappaB complex")complex(a(GO:"membrane attack complex"), p(HGNC:C5))
    Chaotica(CHEBI:acetylcholine)bp(GO:"action potential initiation")p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")bp(GO:"Fas signaling pathway")complex(GO:"NF-kappaB complex")
    Chaotic a(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:DKK1)complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(FPLX:NFkappaB) p(HGNC:IL1B)
    Chaotica(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Chaotica(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)
    Chaotic a(MESH:"Neurofibrillary Tangles")
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:APP)path(MESH:"Alzheimer Disease")p(HGNC:IL1B)p(HGNC:NFKB1)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")p(HGNC:BACE1)p(HGNC:RELA)
    Chaoticp(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")a(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Chaoticcomplex(p(HGNC:FYN), p(HGNC:MAPT))a(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HGNC:CHRNA7)
    Chaoticp(HGNC:FKBP5) p(HGNC:MAPT, pmod(Ph)) path(MESH:"Alzheimer Disease")
    Chaoticp(HGNC:APP, frag("672_713"))p(HGNC:BACE1)path(MESH:"Alzheimer Disease")a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL1B)
    Chaotica(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)a(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))p(HGNC:TNF)
    Chaoticbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT) p(HGNC:MAPT) p(HGNC:SQSTM1)
    Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(FPLX:CHRN)
    Chaotica(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)a(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)
    Chaoticbp(GO:autophagy)a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)
    Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT) p(HGNC:MAPT)p(HGNC:SQSTM1)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:MMP2)path(MESH:"Alzheimer Disease")complex(GO:"inflammasome complex")p(HGNC:IL18)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRNA7)p(HGNC:AGER)path(MESH:"Alzheimer Disease")
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)a(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:TNF)
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade") p(HGNC:CHRNA7)
    Chaotica(CHEBI:acetylcholine)a(CHEBI:galanthamine) p(HGNC:CHRNA7)
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:"response to oxidative stress")bp(GO:autophagy)p(FPLX:JNK)p(HGNC:DKK1)
    Chaotic a(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)complex(GO:"inflammasome complex")p(HGNC:IL1B)
    Chaoticp(HGNC:GSK3B)p(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")p(MGI:"oncostatin M")
    Chaotica(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")
    Chaotica(HBP:"Tau oligomers") p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Brain Injuries, Traumatic")
    Chaotica(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")p(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")path(MESH:Glioblastoma)
    Chaotica(CHEBI:"glutamate(1-)")a(GO:"excitatory synapse")complex(GO:"NF-kappaB complex")
    Chaotic a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")
    Chaotica(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic") p(HGNC:CHRNA7)p(HGNC:JAK2)
    Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)a(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:AGER)a(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")p(FPLX:NFkappaB)
    Chaotica(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
    Chaotica(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")p(FPLX:PKC)
    Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"oncostatin M")path(MESH:Glioblastoma)
    Chaoticp(HGNC:APP, frag("672_713"))p(HGNC:BACE1) path(MESH:"Alzheimer Disease")
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")
    Chaotica(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(MESH:Microglia) bp(GO:phagocytosis)p(HGNC:TREM2)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")p(FPLX:NFkappaB)p(HGNC:BACE1)
    Chaoticbp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))a(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)
    Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT)p(HGNC:MAPT)p(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:TNF)
    Chaotica(CHEBI:"calcium(2+)") a(CHEBI:nicotine)a(MESH:"SNARE Proteins") p(HGNC:CHRNA7)
    Chaoticp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)p(HGNC:SQSTM1)
    Chaotica(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL18)p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")
    Chaotica(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:IL6)
    Chaotic a(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:"inflammatory response")p(HGNC:APP) p(HGNC:DKK1)
    Chaoticp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:SQSTM1)p(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)
    Chaotic a(CHEBI:"amyloid-beta")p(FPLX:TLR)p(HGNC:IL1B)p(HGNC:MAPK14)p(HGNC:RELA)
    Chaotica(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic")p(HGNC:CHRNA7)bp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)
    Chaotic a(CHEBI:"amyloid-beta")a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")p(HGNC:APP)p(HGNC:WNT3A)
    Chaotica(CHEBI:"calcium(2+)")p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)p(HGNC:CDK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")a(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:nicotine)a(MESH:"SNARE Proteins")a(CHEBI:"amyloid-beta")p(HGNC:APOE)path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:acetylcholine)bp(GO:"action potential initiation") p(HGNC:CHRNA7)
    Chaoticbp(GO:"MAPK cascade")p(FPLX:NFkappaB)p(HGNC:TNF)
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP2)path(MESH:"Alzheimer Disease")
    Chaotic a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")
    Chaotic a(CHEBI:"amyloid-beta")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
    Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
    Chaoticbp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)a(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)
    Chaotica(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
    Chaoticp(FPLX:ERK)p(FPLX:NFkappaB)p(HGNC:TNF)
    Chaotic a(CHEBI:"amyloid-beta") complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)p(HGNC:IL18)
    Chaotic a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(CHEBI:"amyloid-beta")bp(GO:"response to oxidative stress")bp(GO:autophagy)
    Chaotica(CHEBI:nicotine)a(CHEBI:"amyloid-beta")p(HGNC:APP)path(MESH:"Alzheimer Disease")
    Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)
    Chaoticbp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))
    Chaotica(CHEBI:"calcium(2+)") p(HGNC:CHRNA7) p(HGNC:CHRNA7)
    Chaotic a(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"inflammatory response")p(HGNC:DKK1)
    Chaoticbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:SQSTM1)
    Chaotica(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
    Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT)
    Chaotic a(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
    Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))p(HGNC:BCL2L1)
    Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
    Dampened a(CHEBI:"amyloid-beta") a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
    Dampened a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
    p(HGNC:CHRNA7)
    Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
    @@ -141362,7 +158864,7 @@

    Causal Pathologies - 324 + 336

    Pathologies are more dogmatically the result of molecular and physical processes, @@ -141445,6 +158947,42 @@

    p(HGNC:MAPT) + + path(HP:"Ischemic stroke") + increases + complex(GO:"NF-kappaB complex") + + + + path(HP:Seizures) + increases + complex(GO:"NF-kappaB complex") + + + + path(MESH:"Alcohol Drinking") + decreases + p(HGNC:ADNP) + + + + path(MESH:"Alcohol Drinking") + increases + p(HGNC:ADNP) + + + + path(MESH:"Alcohol Drinking") + decreases + p(HGNC:TFAP2B) + + + + path(MESH:"Alcohol Drinking") + increases + r(HGNC:ADNP) + + path(MESH:"Alzheimer Disease") decreases @@ -141643,6 +159181,12 @@

    p(FPLX:HSPB) + + path(MESH:"Alzheimer Disease") + decreases + p(FPLX:PPP2) + + path(MESH:"Alzheimer Disease") decreases @@ -142243,6 +159787,12 @@

    p(HGNC:SELENBP1) + + path(MESH:"Alzheimer Disease") + increases + p(HGNC:SET) + + path(MESH:"Alzheimer Disease") decreases @@ -142411,6 +159961,12 @@

    a(HP:"glymphatic system") + + path(MESH:"Brain Injuries, Traumatic") + increases + complex(GO:"NF-kappaB complex") + + path(MESH:"Brain Injuries, Traumatic") decreases @@ -142441,6 +159997,12 @@

    p(HGNC:CHRNA9) + + path(MESH:"Cerebral Infarction") + increases + complex(GO:"NF-kappaB complex") + + path(MESH:"Colorectal Neoplasms") decreases @@ -142801,6 +160363,12 @@

    r(HGNC:TGM2) + + path(MESH:"Thyroiditis, Autoimmune") + increases + p(HGNC:IL1R2) + + path(MESH:"Tobacco Use Disorder") increases @@ -143011,16 +160579,10 @@

    a(MESH:D059329) - - path(MESH:D000544) - increases - a(MESHC:"pro-nerve growth factor, human") - - path(MESH:D000544) decreases - complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) + complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) @@ -143083,12 +160645,6 @@

    p(HGNC:NTRK1) - - path(MESH:D000544) - decreases - r(GFAM:Synaptotagmins) - - path(MESH:D000544) increases @@ -143137,12 +160693,6 @@

    a(MESH:D013569) - - path(MESH:D060825) - increases - a(MESHC:"pro-nerve growth factor, human") - - path(MESH:D060825) increases @@ -143227,6 +160777,24 @@

    a(CHEBI:dopamine) + + path(MESH:Glioblastoma) + increases + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") + + + + path(MESH:Glioblastoma) + increases + p(MGI:"chitinase-like 1") + + + + path(MESH:Hypoxia) + increases + complex(GO:"NF-kappaB complex") + + path(MESH:Inflammation) increases @@ -143263,6 +160831,12 @@

    a(MESH:"Blood-Brain Barrier") + + path(MESH:Smoking) + increases + a(MESH:"Blood Glucose") + + path(MESH:Starvation) increases @@ -143379,11 +160953,11 @@

    bindto: '#chart-node-types', data: { x: 'x', - columns: [["x", "Protein", "Abundance", "Complex", "BiologicalProcess", "Pathology", "Composite", "RNA", "Gene", "Reaction", "miRNA"], ["Node Count", 2090, 1046, 752, 505, 239, 136, 93, 65, 33, 3]], + columns: [["x", "Protein", "Abundance", "Complex", "BiologicalProcess", "Pathology", "Composite", "RNA", "Gene", "Reaction", "miRNA"], ["Node Count", 2215, 1146, 790, 538, 284, 144, 106, 68, 36, 12]], type: 'bar' }, title: { - text: 'Node Types (4962)' + text: 'Node Types (5339)' }, axis: { rotated: true, @@ -143407,11 +160981,11 @@

    bindto: '#chart-edge-types', data: { x: 'x', - columns: [["x", "increases", "decreases", "association", "hasComponent", "positiveCorrelation", "negativeCorrelation", "hasVariant", "regulates", "directlyIncreases", "causesNoChange", "isA", "partOf", "directlyDecreases", "equivalentTo", "hasMember", "hasProduct", "hasReactant", "biomarkerFor", "orthologous"], ["Edge Count", 4691, 2691, 2384, 1835, 1670, 896, 720, 464, 295, 274, 194, 190, 83, 60, 53, 51, 35, 33, 2]], + columns: [["x", "increases", "decreases", "association", "hasComponent", "positiveCorrelation", "negativeCorrelation", "hasVariant", "regulates", "causesNoChange", "directlyIncreases", "isA", "partOf", "directlyDecreases", "equivalentTo", "hasProduct", "hasReactant", "hasMember", "biomarkerFor", "orthologous"], ["Edge Count", 5331, 3158, 2596, 1949, 1792, 946, 755, 583, 323, 295, 201, 190, 83, 60, 54, 39, 33, 32, 2]], type: 'bar' }, title: { - text: 'Edge Types (16621)' + text: 'Edge Types (18422)' }, axis: { rotated: true, @@ -143436,11 +161010,11 @@

    bindto: '#chart-transformations', data: { x: 'x', - columns: [["x", "Molecular Activities", "Translocations", "Degradations"], ["Edge Count", 598, 118, 100]], + columns: [["x", "Molecular Activities", "Translocations", "Degradations"], ["Edge Count", 638, 130, 103]], type: 'bar' }, title: { - text: 'Transformations (816)' + text: 'Transformations (871)' }, axis: { rotated: true, @@ -143466,11 +161040,11 @@

    bindto: '#chart-variants', data: { x: 'x', - columns: [["x", "pmod", "hgvs", "frag"], ["Node Count", 464, 202, 100]], + columns: [["x", "pmod", "hgvs", "frag"], ["Node Count", 491, 206, 104]], type: 'bar' }, title: { - text: 'Variants (766)' + text: 'Variants (801)' }, axis: { rotated: true, @@ -143495,11 +161069,11 @@

    bindto: '#chart-namespaces', data: { x: 'x', - columns: [["x", "HGNC", "MESH", "GO", "HBP", "CHEBI", "MGI", "FPLX", "PUBCHEM", "RGD", "INTERPRO", "HGNCGENEFAMILY", "ECCODE", "HP", "DBSNP", "UNIPROT", "GFAM", "TAXONOMY", "MESHC", "CL", "MIRBASE", "DNSNP", "NCBIGENE", "PFAM", "CTO", "DRUGBANK"], ["Node Count", 1437, 615, 521, 460, 364, 234, 112, 93, 77, 64, 32, 18, 16, 13, 11, 8, 4, 4, 3, 3, 2, 2, 2, 1, 1]], + columns: [["x", "HGNC", "MESH", "GO", "HBP", "CHEBI", "MGI", "FPLX", "PUBCHEM", "RGD", "INTERPRO", "HGNCGENEFAMILY", "HP", "ECCODE", "DBSNP", "UNIPROT", "MIRBASE", "TAXONOMY", "CL", "DNSNP", "NCBIGENE", "PFAM", "DRUGBANK"], ["Node Count", 1538, 686, 560, 467, 410, 256, 137, 121, 77, 64, 32, 18, 18, 13, 12, 6, 4, 3, 2, 2, 2, 1]], type: 'bar' }, title: { - text: 'Namespaces (25)' + text: 'Namespaces (22)' }, axis: { rotated: true, @@ -143523,7 +161097,7 @@

    bindto: '#chart-node-degrees', data: { x: 'x', - columns: [["x", "Alzheimer Disease", "amyloid-beta", "Tau aggregates", "CHRN", "MAPT", "CHRNA7", "nicotine", "autophagy", "GSK3B", "APP", "Cholinergic receptors nicotinic subunits", "HSP90", "cognition", "Tau oligomers"], ["Degree", 1100, 575, 285, 270, 252, 245, 218, 186, 160, 155, 144, 144, 140, 139]], + columns: [["x", "Alzheimer Disease", "amyloid-beta", "Tau aggregates", "CHRN", "MAPT", "nicotine", "CHRNA7", "NF-kappaB complex", "autophagy", "GSK3B", "APP", "Tau oligomers", "memory", "cognition"], ["Degree", 1221, 661, 294, 272, 268, 251, 245, 229, 195, 175, 169, 147, 145, 144]], type: 'bar' }, title: { @@ -143552,7 +161126,7 @@

    bindto: '#chart-pathology-degrees', data: { x: 'x', - columns: [["x", "Alzheimer Disease", "Parkinson Disease", "Tauopathies", "Plaque, Amyloid", "D000544", "Schizophrenia", "Neurodegeneration", "Supranuclear Palsy, Progressive", "Cognitive Dysfunction", "neurotoxicity", "Tobacco Use Disorder", "Frontotemporal Dementia", "Neurodegenerative Diseases", "Protein Aggregation, Pathological", "Dementia"], ["Degree", 1100, 101, 87, 82, 75, 74, 53, 49, 47, 43, 42, 41, 40, 38, 34]], + columns: [["x", "Alzheimer Disease", "Parkinson Disease", "Plaque, Amyloid", "Tauopathies", "Schizophrenia", "D000544", "Neurodegeneration", "Supranuclear Palsy, Progressive", "neurotoxicity", "Cognitive Dysfunction", "Frontotemporal Dementia", "Tobacco Use Disorder", "Neurodegenerative Diseases", "Protein Aggregation, Pathological", "Amyotrophic Lateral Sclerosis"], ["Degree", 1221, 101, 88, 87, 74, 72, 55, 49, 48, 47, 45, 42, 40, 38, 36]], type: 'bar' }, title: { @@ -143580,7 +161154,7 @@

    }, data: { x: 'x', - columns: [["x", "1983-01-01", "1984-01-01", "1985-01-01", "1986-01-01", "1987-01-01", "1988-01-01", "1989-01-01", "1990-01-01", "1991-01-01", "1992-01-01", "1993-01-01", "1994-01-01", "1995-01-01", "1996-01-01", "1997-01-01", "1998-01-01", "1999-01-01", "2000-01-01", "2001-01-01", "2002-01-01", "2003-01-01", "2004-01-01", "2005-01-01", "2006-01-01", "2007-01-01", "2008-01-01", "2009-01-01", "2010-01-01", "2011-01-01", "2012-01-01", "2013-01-01", "2014-01-01", "2015-01-01", "2016-01-01", "2017-01-01", "2018-01-01", "2019-01-01"], ["Number of Articles", 0, 1, 0, 0, 2, 1, 0, 1, 1, 0, 3, 2, 1, 5, 2, 0, 4, 2, 4, 3, 6, 2, 2, 8, 9, 16, 14, 4, 20, 22, 26, 29, 27, 36, 34, 29, 1]] + columns: [["x", "1983-01-01", "1984-01-01", "1985-01-01", "1986-01-01", "1987-01-01", "1988-01-01", "1989-01-01", "1990-01-01", "1991-01-01", "1992-01-01", "1993-01-01", "1994-01-01", "1995-01-01", "1996-01-01", "1997-01-01", "1998-01-01", "1999-01-01", "2000-01-01", "2001-01-01", "2002-01-01", "2003-01-01", "2004-01-01", "2005-01-01", "2006-01-01", "2007-01-01", "2008-01-01", "2009-01-01", "2010-01-01", "2011-01-01", "2012-01-01", "2013-01-01", "2014-01-01", "2015-01-01", "2016-01-01", "2017-01-01", "2018-01-01", "2019-01-01"], ["Number of Articles", 0, 1, 0, 0, 2, 1, 0, 1, 1, 0, 3, 2, 1, 5, 2, 0, 4, 2, 4, 4, 6, 2, 2, 8, 9, 16, 15, 4, 21, 25, 27, 29, 30, 37, 36, 32, 4]] }, bindto: '#chart-publication-years', axis: { @@ -143615,7 +161189,7 @@

    type: 'bar' }, title: { - text: 'Authors (1781)' + text: 'Authors (1892)' }, axis: { rotated: true, @@ -143640,7 +161214,7 @@

    bindto: '#chart3', data: { x: 'x', - columns: [["x", "MissingNamespaceNameWarning"], ["Error Type", 28]], + columns: [["x", "MissingNamespaceNameWarning"], ["Error Type", 58]], type: 'bar' }, title: { @@ -143669,7 +161243,7 @@

    bindto: '#chart-confidence-count', data: { x: 'x', - columns: [["x", "None", "Very Low", "Low", "Medium", "High", "Very High"], ["Edge Count", 12043, 0, 33, 578, 1273, 0]], + columns: [["x", "None", "Very Low", "Low", "Medium", "High", "Very High"], ["Edge Count", 13708, 0, 33, 578, 1273, 0]], type: 'bar' }, title: {