diff --git a/.changeset/good-buttons-bake.md b/.changeset/good-buttons-bake.md
new file mode 100644
index 000000000..cb0e39e24
--- /dev/null
+++ b/.changeset/good-buttons-bake.md
@@ -0,0 +1,5 @@
+---
+'openapi-react-query': minor
+---
+
+Add `prefixQueryKey` to `createClient` to avoid query key collision between different openapi-fetch clients.
diff --git a/packages/openapi-react-query/src/index.ts b/packages/openapi-react-query/src/index.ts
index cbee066c0..a319ca5c2 100644
--- a/packages/openapi-react-query/src/index.ts
+++ b/packages/openapi-react-query/src/index.ts
@@ -1,35 +1,34 @@
-import {
-  type UseMutationOptions,
-  type UseMutationResult,
-  type UseQueryOptions,
-  type UseQueryResult,
-  type UseSuspenseQueryOptions,
-  type UseSuspenseQueryResult,
-  type QueryClient,
-  type QueryFunctionContext,
-  type SkipToken,
-  useMutation,
-  useQuery,
-  useSuspenseQuery,
+import type {
+  QueryClient,
+  QueryFunctionContext,
+  SkipToken,
+  UseMutationOptions,
+  UseMutationResult,
+  UseQueryOptions,
+  UseQueryResult,
+  UseSuspenseQueryOptions,
+  UseSuspenseQueryResult,
 } from "@tanstack/react-query";
-import type { ClientMethod, FetchResponse, MaybeOptionalInit, Client as FetchClient } from "openapi-fetch";
+import { useMutation, useQuery, useSuspenseQuery } from "@tanstack/react-query";
+import type { ClientMethod, Client as FetchClient, FetchResponse, MaybeOptionalInit } from "openapi-fetch";
 import type { HttpMethod, MediaType, PathsWithMethod, RequiredKeysOf } from "openapi-typescript-helpers";
 
 type InitWithUnknowns<Init> = Init & { [key: string]: unknown };
 
 export type QueryKey<
+  Prefix,
   Paths extends Record<string, Record<HttpMethod, {}>>,
   Method extends HttpMethod,
   Path extends PathsWithMethod<Paths, Method>,
-> = readonly [Method, Path, MaybeOptionalInit<Paths[Path], Method>];
+> = readonly [Prefix, Method, Path, MaybeOptionalInit<Paths[Path], Method>];
 
-export type QueryOptionsFunction<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType> = <
+export type QueryOptionsFunction<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType, Prefix = unknown> = <
   Method extends HttpMethod,
   Path extends PathsWithMethod<Paths, Method>,
   Init extends MaybeOptionalInit<Paths[Path], Method>,
   Response extends Required<FetchResponse<Paths[Path][Method], Init, Media>>, // note: Required is used to avoid repeating NonNullable in UseQuery types
   Options extends Omit<
-    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Paths, Method, Path>>,
+    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Prefix, Paths, Method, Path>>,
     "queryKey" | "queryFn"
   >,
 >(
@@ -40,23 +39,23 @@ export type QueryOptionsFunction<Paths extends Record<string, Record<HttpMethod,
     : [InitWithUnknowns<Init>, Options?]
 ) => NoInfer<
   Omit<
-    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Paths, Method, Path>>,
+    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Prefix, Paths, Method, Path>>,
     "queryFn"
   > & {
     queryFn: Exclude<
-      UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Paths, Method, Path>>["queryFn"],
+      UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Prefix, Paths, Method, Path>>["queryFn"],
       SkipToken | undefined
     >;
   }
 >;
 
-export type UseQueryMethod<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType> = <
+export type UseQueryMethod<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType, Prefix = unknown> = <
   Method extends HttpMethod,
   Path extends PathsWithMethod<Paths, Method>,
   Init extends MaybeOptionalInit<Paths[Path], Method>,
   Response extends Required<FetchResponse<Paths[Path][Method], Init, Media>>, // note: Required is used to avoid repeating NonNullable in UseQuery types
   Options extends Omit<
-    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Paths, Method, Path>>,
+    UseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Prefix, Paths, Method, Path>>,
     "queryKey" | "queryFn"
   >,
 >(
@@ -67,13 +66,13 @@ export type UseQueryMethod<Paths extends Record<string, Record<HttpMethod, {}>>,
     : [InitWithUnknowns<Init>, Options?, QueryClient?]
 ) => UseQueryResult<Response["data"], Response["error"]>;
 
-export type UseSuspenseQueryMethod<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType> = <
+export type UseSuspenseQueryMethod<Paths extends Record<string, Record<HttpMethod, {}>>, Media extends MediaType, Prefix = unknown> = <
   Method extends HttpMethod,
   Path extends PathsWithMethod<Paths, Method>,
   Init extends MaybeOptionalInit<Paths[Path], Method>,
   Response extends Required<FetchResponse<Paths[Path][Method], Init, Media>>, // note: Required is used to avoid repeating NonNullable in UseQuery types
   Options extends Omit<
-    UseSuspenseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Paths, Method, Path>>,
+    UseSuspenseQueryOptions<Response["data"], Response["error"], Response["data"], QueryKey<Prefix, Paths, Method, Path>>,
     "queryKey" | "queryFn"
   >,
 >(
@@ -97,21 +96,22 @@ export type UseMutationMethod<Paths extends Record<string, Record<HttpMethod, {}
   queryClient?: QueryClient,
 ) => UseMutationResult<Response["data"], Response["error"], Init>;
 
-export interface OpenapiQueryClient<Paths extends {}, Media extends MediaType = MediaType> {
-  queryOptions: QueryOptionsFunction<Paths, Media>;
-  useQuery: UseQueryMethod<Paths, Media>;
-  useSuspenseQuery: UseSuspenseQueryMethod<Paths, Media>;
+export interface OpenapiQueryClient<Paths extends {}, Media extends MediaType = MediaType, Prefix = unknown> {
+  queryOptions: QueryOptionsFunction<Paths, Media, Prefix>;
+  useQuery: UseQueryMethod<Paths, Media, Prefix>;
+  useSuspenseQuery: UseSuspenseQueryMethod<Paths, Media, Prefix>;
   useMutation: UseMutationMethod<Paths, Media>;
 }
 
 // TODO: Add the ability to bring queryClient as argument
-export default function createClient<Paths extends {}, Media extends MediaType = MediaType>(
+export default function createClient<Paths extends {}, Media extends MediaType = MediaType, T = unknown>(
   client: FetchClient<Paths, Media>,
-): OpenapiQueryClient<Paths, Media> {
+  { prefixQueryKey }: { prefixQueryKey?: T } = {},
+): OpenapiQueryClient<Paths, Media, T> {
   const queryFn = async <Method extends HttpMethod, Path extends PathsWithMethod<Paths, Method>>({
-    queryKey: [method, path, init],
+    queryKey: [, method, path, init],
     signal,
-  }: QueryFunctionContext<QueryKey<Paths, Method, Path>>) => {
+  }: QueryFunctionContext<QueryKey<T, Paths, Method, Path>>) => {
     const mth = method.toUpperCase() as Uppercase<typeof method>;
     const fn = client[mth] as ClientMethod<Paths, typeof method, Media>;
     const { data, error } = await fn(path, { signal, ...(init as any) }); // TODO: find a way to avoid as any
@@ -122,8 +122,8 @@ export default function createClient<Paths extends {}, Media extends MediaType =
     return data;
   };
 
-  const queryOptions: QueryOptionsFunction<Paths, Media> = (method, path, ...[init, options]) => ({
-    queryKey: [method, path, init as InitWithUnknowns<typeof init>] as const,
+  const queryOptions: QueryOptionsFunction<Paths, Media, T> = (method, path, ...[init, options]) => ({
+    queryKey: [prefixQueryKey as T, method, path, init as InitWithUnknowns<typeof init>] as const,
     queryFn,
     ...options,
   });
diff --git a/packages/openapi-react-query/test/index.test.tsx b/packages/openapi-react-query/test/index.test.tsx
index 294175df9..602626ada 100644
--- a/packages/openapi-react-query/test/index.test.tsx
+++ b/packages/openapi-react-query/test/index.test.tsx
@@ -231,6 +231,33 @@ describe("client", () => {
       expectTypeOf(result.current.data).toEqualTypeOf<"select(true)">();
       expectTypeOf(result.current.error).toEqualTypeOf<false | null>();
     });
+
+    it('should differentiate queries by prefixQueryKey', async () => {
+      const fetchClient1 = createFetchClient<minimalGetPaths>({ baseUrl, fetch: fetchInfinite });
+      const fetchClient2 = createFetchClient<minimalGetPaths>({ baseUrl, fetch: fetchInfinite });
+      const client1 = createClient(fetchClient1);
+      const client11 = createClient(fetchClient1);
+      const client2 = createClient(fetchClient2, { prefixQueryKey: ['cache2'] as const });
+
+      renderHook(
+        () => {
+          useQueries({
+            queries: [
+              client1.queryOptions('get', '/foo'),
+              client11.queryOptions('get', '/foo'),
+              client2.queryOptions('get', '/foo'),
+            ],
+          });
+        },
+        { wrapper },
+      );
+
+      expectTypeOf(client1.queryOptions('get', '/foo').queryKey[0]).toEqualTypeOf<unknown>();
+      expectTypeOf(client2.queryOptions('get', '/foo').queryKey[0]).toEqualTypeOf<readonly ['cache2']>();
+
+      // client1 and client11 have the same query key, so 3 - 1 = 2
+      expect(queryClient.isFetching()).toBe(2);
+    });
   });
 
   describe("useQuery", () => {