[NTR] Chimeric Antigen Receptor T-cell

[xnrxng]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
CAR T-cell

Synonyms (add reference(s), please)
Chimeric Antigen Receptor T-cell
Chimeric Antigen Receptor T cell
CAR T cell
CART

Zhang C, Durer S, Thandra KC, et al. Chimeric Antigen Receptor T-Cell Therapy. [Updated 2022 Oct 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537294/

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
T cells that have been engineered to express a Chimeric Antigen Receptor, which signals T cells to attack tumor cells.
32301017

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
T cell (CL_0000084)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
N/A

Your ORCID

Additional notes or concerns

[addiehl]

Because this is an engineered cell, we would not normally consider it in scope for the Cell Ontology.

[emquardokus]

@addiehl would Cell Line Ontology (CLO) be appropriate to add CAR T cells? They are primary cultured cells, mortal cell line
Sarntivijai, Sirarat, Yu Lin, Zuoshuang Xiang, Terrence F. Meehan, Alexander D. Diehl, Uma D. Vempati, Stephan C. Schürer, et al. 2014. “CLO: The Cell Line Ontology.” Journal of Biomedical Semantics 5:37. https://doi.org/10.1186/2041-1480-5-37.