NTRs: Fibrotic & inflammatory fibroblasts

[dosumis]

These might be considered 'states', but there are clear signatures.

Lung examples here
https://www.nature.com/articles/s41590-024-01934-6

Broader search - inflammatory https://www.perplexity.ai/search/are-there-common-markers-and-t-n2x5qhrVT8mI13IYeTWwBA

Broader search - fibrotic https://www.perplexity.ai/search/are-there-common-markers-and-t-mawpZGg.TSif5ElwaUaD4w

[aleixpuigb]

Bibliography from the MIRO board:

• Peyser R, MacDonnell S, Gao Y, Cheng L, Kim Y, Kaplan T, Ruan Q, Wei Y, Ni M, Adler C, Zhang W, Devalaraja-Narashimha K, Grindley J, Halasz G, Morton L. Defining the Activated Fibroblast Population in Lung Fibrosis Using Single-Cell Sequencing. Am J Respir Cell Mol Biol. 2019 Jul;61(1):74-85. doi: 10.1165/rcmb.2018-0313OC. PMID: 30848683.
• Mayr CH, Sengupta A, Asgharpour S, Ansari M, Pestoni JC, Ogar P, Angelidis I, Liontos A, Rodriguez-Castillo JA, Lang NJ, Strunz M, Porras-Gonzalez D, Gerckens M, De Sadeleer LJ, Oehrle B, Viteri-Alvarez V, Fernandez IE, Tallquist M, Irmler M, Beckers J, Eickelberg O, Stoleriu GM, Behr J, Kneidinger N, Wuyts WA, Wasnick RM, Yildirim AÖ, Ahlbrecht K, Morty RE, Samakovlis C, Theis FJ, Burgstaller G, Schiller HB. Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts. Eur Respir J. 2024 Feb 8;63(2):2301326. doi: 10.1183/13993003.01326-2023. PMID: 38212077; PMCID: PMC10850614.
• Rodriguez LR, Tang SY, Roque Barboza W, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Cooper CH, Dimopoulos TT, Babu A, Connelly C, FitzGerald GA, Beers MF. PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice. JCI Insight. 2023 Dec 22;8(24):e172977. doi: 10.1172/jci.insight.172977. PMID: 37934604; PMCID: PMC10807712.