[NTR] subtypes of tanycyte - alpha1,2; Beta 1,2 #2256
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@dosumis thanks for your ticket. Here there is the work to do for these cell types tanycyteA specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. A tanycyte is found in the adult brain, specifically in the third ventricle, cerebral aqueduct, spinal canal, and floor of the fourth ventricle. This cell type is involved in hormonal regulation, gatekeeping molecules between the bloodstream and cerebrospinal fluid, metabolic sensing, and regulating food intake. has_broad_synonym has_broad_synonym has_related_synonym α1-tanycytedefinition: database_cross_reference: extended definition: database_cross_reference: has_exact_synonym: has_exact_synonym: has_exact_synonym: has_broad_synonym Logical definition taxon: mice, humans α2-tanycyteA type of tanycyte has its soma located in the dorsomedial arcuate nucleus of the hypothalamus. This mono-ciliated tanycyte extends its protrusion to the arcuate nucleus and expresses the glial marker S-100β. database_cross_reference: additional_definition database_cross_reference: has_related_synonym: has_exact_synonym: has_broad_synonym Logical definition taxon: mice, humans β1-tanycyteA type of tanycyte that has its soma located in the lateral infundibular recess of the brain. This tanycyte has an elongated morphology with multiple microvilli extending to the third ventricle in the lateral zones of the median eminence. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH). https://en.wikipedia.org/wiki/Tanycyte has_exact_synonym: has_broad_synonym: has_related_synonym: logical definition: taxon: mice, humans β2-tanycyteA type of tanycyte that has its soma located in the floor of the infundibular recess in the brain. This tanycyte has an elongated morphology with multiple microvilli extending medially and ventrally to the median eminence, contacting the pial surface and blood vessels. This type of tanycyte expresses FGF receptors 1 and 2, is in contact with GnRH neurons, and is involved in the release of gonadotropin-releasing hormone (GnRH). database_cross_reference: has_related_synonym: has_exact_synonym: has_broad_synonym: Logical definition: @JABelfiore please review content and text ! |
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[tanycyte] has_broad_synonym Paper cited frequently uses “resemblance to radial glial cells” which means the same as “radial glia-like cell”, but can't find the specific wording in the paper. has_broad_synonym “residual radial glia cell” does not exist in paper However, stretched cells exist in this paper. has_related_synonym Can’t access this document. Suggest replacing reference with PMID:29351662 α1-tanycyte has_exact_synonym: has_exact_synonym: has_exact_synonym: has_broad_synonym Logical definition looks good α2-tanycyte database_cross_reference: Additional_definition looks good PMID:26578855 confirms expression Logical definition: looks good |
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thank you @JABelfiore ! will turn this into a PR! |
* Re-done-t-type-GABAergic-VIP-cortical-interneuron-definition fixes #2256 To follow changes in this PR, read @AmgAvola comments in the ticket #2256 Alpha1,2 Beta1,2 tanycyte added with definition, references, synonyms and logical definition. * Update cl-edit.owl add logical SubClass * Remove unwanted parent term in imported PR term * Update cl-edit.owl --------- Co-authored-by: aleixpuig <[email protected]>
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Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl
Preferred term label
alpha 1 tanycyte
alpha 2 tanycyte
beta 1 tanycyte
beta 2 tanycyte
Synonyms (add reference(s), please)
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
Review here: DOI: 10.1016/S0074-7696(05)47003-5
Table II has a good summary of differences in location, morphology and gene expression. Looks like location and morphology might be sufficient to distinguish.
May be worth looking back at some more classical papers - review references EM studies from the 70s.
Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
Your ORCID
Additional notes or concerns
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