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t-type-GABAergic-VIP-cortical-interneuron-definition (#2489)
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Fixes #2344
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AvolaAmg authored Aug 20, 2024
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11 changes: 10 additions & 1 deletion src/ontology/cl-edit.owl
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Expand Up @@ -29223,10 +29223,19 @@ SubClassOf(obo:CL_4023015 obo:CL_4023064)
# Class: obo:CL_4023016 (VIP GABAergic cortical interneuron)

AnnotationAssertion(obo:IAO_0000028 obo:CL_4023016 "VIP cortical interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33186530") Annotation(oboInOwl:hasDbXref "PMID:37824655") obo:IAO_0000115 obo:CL_4023016 "A GABAergic neuron located in the cerebral cortex that expresses vasoactive intestinal polypeptide")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33186530") Annotation(oboInOwl:hasDbXref "PMID:37824655") Annotation(oboInOwl:hasDbXref "https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/") obo:IAO_0000115 obo:CL_4023016 "A transcriptomically distinct cortical GABAergic neuron that expresses the vasocactive intestinal polypeptide and that has its soma located in the cerebral cortex. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', cluster Vip.")
AnnotationAssertion(terms:contributor obo:CL_4023016 <https://orcid.org/0000-0001-7258-9596>)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33108272") oboInOwl:hasBroadSynonym obo:CL_4023016 "VIP interneuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33108272") oboInOwl:hasBroadSynonym obo:CL_4023016 "VIP neuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35221922") oboInOwl:hasBroadSynonym obo:CL_4023016 "VIP-Expressing GABAergic Neuron")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ILX:0770151") oboInOwl:hasBroadSynonym obo:CL_4023016 "Vip GABAergic neuron")
AnnotationAssertion(oboInOwl:hasDbXref obo:CL_4023016 "ILX:0770151")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37824655") oboInOwl:hasRelatedSynonym obo:CL_4023016 "VIP type")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33794534") oboInOwl:hasRelatedSynonym obo:CL_4023016 "VIP-IN")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ILX:0770151") oboInOwl:hasRelatedSynonym obo:CL_4023016 "Vip")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36384143") oboInOwl:hasRelatedSynonym obo:CL_4023016 "cortical VIP neuron")
AnnotationAssertion(oboInOwl:inSubset obo:CL_4023016 cl:BDS_subset)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26420784") Annotation(oboInOwl:hasDbXref "PMID:31210267") Annotation(oboInOwl:hasDbXref "PMID:33794534") Annotation(oboInOwl:hasDbXref "PMID:35221922") rdfs:comment obo:CL_4023016 "This neuronal type is distinguished by its heterogeneous morphology and electrophysiological characteristics (Pronneke et al., 2015,2020; Apicella and Marchionni, 2022). Variations in morphology and firing patterns are observed in human cortical VIP interneurons. In a study by Lee et al., 2023, four distinct subtypes of VIP neurons were identified, each exhibiting unique morphologies, soma locations, and electrophysiological properties. These subtypes are defined according to their transcriptomic markers: LBH-VIP and CCD184-VIP, both of which display a bipolar morphology with axons and dendrites extending across cortical layers; and SY16-VIP and ADAMTSL1-VIP, characterized by a dendritic arbor that spreads horizontally within the same layer as the soma (Lee et al., 2023). Disruption or malfunction of VIP cortical interneuron is implicated in neurodevelopmental disorders such as Rett Syndrome and Dravet Syndrome (Goff and Goldberg 2021).")
AnnotationAssertion(rdfs:label obo:CL_4023016 "VIP GABAergic cortical interneuron")
EquivalentClasses(obo:CL_4023016 ObjectIntersectionOf(obo:CL_0000099 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_0000956) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000017299)))
SubClassOf(obo:CL_4023016 obo:CL_4023064)
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