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At Cassie's Overbaugh lab meeting today, @psathyrella and @krdav helped us conclude that it would be helpful to view trees that are collapsed to differences in amino acids. I'm not clear on if it would be easier to just build amino acid-based trees from the partis clusters or, as @krdav explained today, perhaps some of the nodes/branches could be collapsed based on same or different amino acid sequence. This would cut down on the bushiness of these trees within our clonal families of interest.
On our end, we need to know about the Ab evolution (which is nt based), but we only care about actually generation different Ab amino acid sequences.
I'd favor just indicating edges with amino acid changes with a color or something. If we have an AA tree and a NT tree that's just going to get confusing IMHO.
@lauradoepker commented on Wed Mar 22 2017
At Cassie's Overbaugh lab meeting today, @psathyrella and @krdav helped us conclude that it would be helpful to view trees that are collapsed to differences in amino acids. I'm not clear on if it would be easier to just build amino acid-based trees from the partis clusters or, as @krdav explained today, perhaps some of the nodes/branches could be collapsed based on same or different amino acid sequence. This would cut down on the bushiness of these trees within our clonal families of interest.
On our end, we need to know about the Ab evolution (which is nt based), but we only care about actually generation different Ab amino acid sequences.
@matsen commented on Wed Mar 22 2017
I'd favor just indicating edges with amino acid changes with a color or something. If we have an AA tree and a NT tree that's just going to get confusing IMHO.
@metasoarous commented on Wed Mar 22 2017
Yeah; I'm with @matsen on this. Annotating the tree seems like a better approach to me. Permission to change title?
Will probably be easier to do this sort of things once we're all dynamic on the front end.
@lauradoepker commented on Thu Mar 23 2017
@metasoarous yes, sounds good
@metasoarous commented on Thu Mar 23 2017
Given #99 this would probably just mean adding an attribute to the json tree nodes and setting up an option to color by that.
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