From d0a49aeabba01b75d1f0d1061a2f20c1404d1337 Mon Sep 17 00:00:00 2001 From: Max Schubach Date: Wed, 13 Nov 2024 10:41:22 +0100 Subject: [PATCH] update readme --- README.md | 14 ++++++++++++++ 1 file changed, 14 insertions(+) diff --git a/README.md b/README.md index 2f18e56..c95e157 100644 --- a/README.md +++ b/README.md @@ -130,6 +130,20 @@ You can test whether your CADD is set up properly by comparing to the example fi ### Update +### Version 1.6.1 + +Just a CADD-Script version update for snakemake 8 compatibility and containerization. CADD scores are the same as with CADD-script v1.6 (CADD scores v1.6). Detailed changes: + +- only snakemake >= 8.25.2 supported +- using only conda-forge and bioconda channels (no default anymore) +- conda container docker://visze/cadd-scripts-v1_6:0.1.0 +- only conda >24.7.1 is allowed (no mamba support anymore) +- VCF2vepVCF.py script fix to extend header. Otherwise regseq will fail using the vcf library +- readme update + + +### Version 1.6 + Version 1.6 includes some changes in comparison to v1.5. Next to the obvious switch of the pipeline into a Snakemake workflow which became necessary due to the ongoin issues with `conda activate`, the new models for v1.6 are extended by more specialized annotations for splicing variants, as well as a few minor changes in some other annotations (most prominent: fixed gerp for GRCh38) and changes in consequence categories which make this scripts incompatible with CADD v1.4 and v1.5. If you are still using those version, please use [version 1.5 of this repository](https://github.com/kircherlab/CADD-scripts/archive/CADD1.5.zip). ```