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Build out and test a version of patternDrivers using VGAM DE testing. #5

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Loyale opened this issue Aug 10, 2018 · 0 comments
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Loyale commented Aug 10, 2018

To identify features outside of the feature map that are associated with projected weights, we want to implement a version of patternDrivers (or call it another test) where we do a DE gene test in the target gene expression space (after projection from source) using VGAM with appropriate family (negbinomial). This would be a 'standard' DE gene test using estimated P-weights from a projection as an explanatory variable. The goal is to identify genes in the target space whose expression is a function of P-weights for interesting/significant patterns.

@Loyale Loyale added this to the v2.0 milestone Aug 10, 2018
@Loyale Loyale self-assigned this Aug 10, 2018
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