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To identify features outside of the feature map that are associated with projected weights, we want to implement a version of patternDrivers (or call it another test) where we do a DE gene test in the target gene expression space (after projection from source) using VGAM with appropriate family (negbinomial). This would be a 'standard' DE gene test using estimated P-weights from a projection as an explanatory variable. The goal is to identify genes in the target space whose expression is a function of P-weights for interesting/significant patterns.
The text was updated successfully, but these errors were encountered:
To identify features outside of the feature map that are associated with projected weights, we want to implement a version of patternDrivers (or call it another test) where we do a DE gene test in the target gene expression space (after projection from source) using VGAM with appropriate family (negbinomial). This would be a 'standard' DE gene test using estimated P-weights from a projection as an explanatory variable. The goal is to identify genes in the target space whose expression is a function of P-weights for interesting/significant patterns.
The text was updated successfully, but these errors were encountered: