diff --git a/CHANGES.rst b/CHANGES.rst
index 897d7f82d6..8322e42cef 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -226,7 +226,9 @@ mast
 - Present users with an error when nonexistent query criteria are used in ``mast.MastMissions`` query functions. [#3126]
 
 - Present users with an error when nonexistent query criteria are used in ``mast.Catalogs.query_region`` and 
-  ``mast.Catalogs.query_object`` [#3126]
+  ``mast.Catalogs.query_object``. [#3126]
+
+- Handle HLSP data products in ``Observations.get_cloud_uris``. [#3126]
 
 mpc
 ^^^
diff --git a/astroquery/mast/tests/test_mast_remote.py b/astroquery/mast/tests/test_mast_remote.py
index 89a5cd6f00..08f960c647 100644
--- a/astroquery/mast/tests/test_mast_remote.py
+++ b/astroquery/mast/tests/test_mast_remote.py
@@ -605,7 +605,7 @@ def test_get_cloud_uri(self, test_data_uri, expected_cloud_uri):
         assert len(uri) > 0, f'Product for dataURI {test_data_uri} was not found in the cloud.'
         assert uri == expected_cloud_uri, f'Cloud URI does not match expected. ({uri} != {expected_cloud_uri})'
 
-    @pytest.mark.parametrize("test_obs_id", ["25568122", "31411"])
+    @pytest.mark.parametrize("test_obs_id", ["25568122", "31411", "107604081"])
     def test_get_cloud_uris(self, test_obs_id):
         pytest.importorskip("boto3")
 
diff --git a/astroquery/mast/utils.py b/astroquery/mast/utils.py
index 9f7a25d731..56bfa5810a 100644
--- a/astroquery/mast/utils.py
+++ b/astroquery/mast/utils.py
@@ -194,6 +194,8 @@ def mast_relative_path(mast_uri):
                 path = path.lstrip("/mast/")
             elif '/ps1/' in path:
                 path = path.replace("/ps1/", "panstarrs/ps1/public/")
+            elif 'hlsp' in path:
+                path = path.replace("/hlsp_local/public/", "mast/")
             else:
                 path = path.lstrip("/")
             result.append(path)