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about

EDUCATION

The University of Michigan, Ann Arbor, MI
M.S. in Bioinformatics
Courses: Machine & Deep Learning, NLP, Molecular Genetics, Bioinformatics programming skills, Computational Neuroscience

Sep. 2019 – April 2020

B.S. in Life Science Informatics
Courses: Data Structure & Algorithm, Theoretical Statistics, Linear Algebra, Biochemistry

Jan. 2018 – June 2019

Green River College, Auburn, WA

Sep. 2015 – June 2017

RESEARCH EXPERIENCE

Tumor heterogeneity (two projects), Guan’s lab at the University of Michigan

  • Explained a possible driving force (copy number alteration event) that causes the formation of multi-clone tumors with a Pan-Cancer dataset. The manuscript will be submitted as soon as possible after the final revision
  • Developed a tool called FastClone for reconstructing tumor phylogeny. FastClone achieves approximately 100-fold acceleration in computation for both simulated data and 15 patient data compared to other tools. The paper is published in Nature Communications

2019 – 2021

Chemical properties transformation, Guan’s lab at the University of Michigan

  • Built a framework of graph conditional variational autoencoder that could transform chemical properties by generating an analog based on graphs and properties of known compounds. The crucial idea of my framework was using three decoders to generate chemical bonds, atoms, and chemical properties, respectively

2020 – 2021

Drug response prediction, Dr. Wenjun Ju’s lab at the University of Michigan (cooperation)

  • Used SHAP to determine biomarkers that are associated with renal response to Atrasentan drug, and selected a machine learning model with the highest AUC score

2020

Biological pathway associated with aging, Dr. Lisa Sharkey‘s lab at the University of Michigan (cooperation)

  • Used WGCNA and DAVID to find out biological pathways in mice that are associated with anti-aging treatments

2018

PUBLICATIONS

First Author of a Nat. Commun. paper

  • Xiao, Y. et al. FastClone is a probabilistic tool for deconvoluting tumor heterogeneity in bulk-sequencing samples. Nat. Commun. 11, 4469 (2020)

Link to this paper


SKILLS

Computer: Python, R, C++, Adobe Illustrator

Language: Chinese (High level), English (High level), Wenzhounese (Chinese dialect, High level)

Instruments: Tenor saxophone, Guitar


WORKING EXPERIENCE

Lana Garmire’s lab at the University of Michigan, Ann Arbor, MI
Research Associate

  • Started to work on a drug repurposing project

Oct. 2021 - Present

Guan’s lab at the University of Michigan, Ann Arbor, MI
Research Associate

  • Conducted research projects
  • Cooperated with other labs

April 2020 - Sep. 2021

Kid Castle, Wenzhou, Zhejiang, China
English Tutor

  • Taught basic English grammar and pronunciation
  • Assisted other teachers with managing classes
  • Graded student’s assignments

Sep. 2017 – Dec. 2017

Zhejiang Dongou Diagnostic Reagent Limited Company, Wenzhou, Zhejiang, China
Surveyor Assistant (Internship)

  • Managed the data of triglyceride and glucose level, which are produced by Hitachi H7180 Clinical Analyzer

June 2017 – July 2017

Youshare, Hangzhou, Zhejiang, China
Salesman (Internship)

  • Taught senior people how to use smartphones or computers to access Youshare’s applications
  • Introduced Yourshare’s health care products to new customers
  • Assisted manager in arranging product conference

Aug. 2016 – Sep. 2016

ACTIVITIES & LEADERSHIP

Wenzhou high school summer campaign, Wenzhou, Zhejiang, China
Volunteer

  • Recorded students’ activities with camera and made a video for them

Aug. 2017

Food Recipe Club, Green River College, Auburn, WA
Vice minister

  • The club's purpose was to help members learn about other countries' food cultures and have better diets
  • Collected food recipes from members
  • Organized cooking events

Mar. 2016 – April 2017