This work was supported by Microsoft (MB, DB, and generous gifts of Azure compute time and expertise), Eric and Wendy Schmidt by recommendation of the Schmidt Futures program (FD, HP), Open Philanthropy (DB, GRL), The Washington Research Foundation (MB, GRL, JW), National Science Foundation Cyberinfrastructure for Biological Research, Award # DBI 1937533 (IA), Wellcome Trust, grant number 209407/Z/17/Z (RJR), National Institute of Health, grant numbers P01GM063210 (PDA, RJR), DP5OD026389 (SO), Global Challenges Research Fund (GCRF) through Science & Technology Facilities Council (STFC), grant number ST/R002754/1: Synchrotron Techniques for African Research and Technology (START) (DJO), Austrian Science Fund (FWF) projects P29432 and DOC50 (doc.fund Molecular Metabolism) (TS, CB, TP).